Miriam Aceves, Ashley Tucker, Joseph Chen, Katie Vo, Joshua Moses, Prakruthi Amar Kumar, Hannah Thomas, Diego Miranda, Gabrielle Dampf, Valerie Dietz, Matthew Chang, Aleena Lukose, Julius Jang, Sneha Nadella, Tucker Gillespie, Christian Trevino, Andrew Buxton, Anna L Pritchard, Peyton Green, Dylan A McCreedy, Jennifer N Dulin
Neural progenitor cell (NPC) transplantation is a promising therapeutic strategy for replacing lost neurons following spinal cord injury (SCI). However, how graft cellular composition influences regeneration and synaptogenesis of host axon populations, or recovery of motor and sensory functions after SCI, is poorly understood. We transplanted developmentally-restricted spinal cord NPCs, isolated from E11.5-E13.5 mouse embryos, into sites of adult mouse SCI and analyzed graft axon outgrowth, cellular composition, host axon regeneration, and behavior...
May 19, 2023: Communications Biology