keyword
MENU ▼
Read by QxMD icon Read
search

horn cell axon

keyword
https://www.readbyqxmd.com/read/28441464/crucial-roles-of-pox-neuro-in-the-developing-ellipsoid-body-and-antennal-lobes-of-the-drosophila-brain
#1
Shilpi Minocha, Werner Boll, Markus Noll
The paired box gene Pox neuro (Poxn) is expressed in two bilaterally symmetric neuronal clusters of the developing adult Drosophila brain, a protocerebral dorsal cluster (DC) and a deutocerebral ventral cluster (VC). We show that all cells that express Poxn in the developing brain are postmitotic neurons. During embryogenesis, the DC and VC consist of only 20 and 12 neurons that express Poxn, designated embryonic Poxn-neurons. The number of Poxn-neurons increases only during the third larval instar, when the DC and VC increase dramatically to about 242 and 109 Poxn-neurons, respectively, virtually all of which survive to the adult stage, while no new Poxn-neurons are added during metamorphosis...
2017: PloS One
https://www.readbyqxmd.com/read/28428485/pathological-lesions-in-the-central-nervous-system-and-peripheral-tissues-of-ddy-mice-with-street-rabies-virus-1088-strain
#2
Kazunori Kimitsuki, Kentaro Yamada, Nozomi Shiwa, Satoshi Inoue, Akira Nishizono, Chun-Ho Park
Most studies on rabies virus pathogenesis in animal models have employed fixed rabies viruses, and the results of those employing street rabies viruses have been inconsistent. Therefore, to clarify the pathogenesis of street rabies virus (1088 strain) in mice, 10(6) focus forming units were inoculated into the right hindlimb of ddY mice (6 weeks, female). At 3 days postinoculation (DPI), mild inflammation was observed in the hindlimb muscle. At 5 DPI, ganglion cells in the right lumbosacral spinal dorsal root ganglia showed chromatolysis...
April 20, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28380320/reappraisal-of-the-f-m-amplitude-ratio-in-carpal-tunnel-syndrome
#3
F Ginanneschi, M Mondelli, A Aretini, Alessandro Rossi
The F-wave/M-wave amplitude (F/M-amp) ratio has been shown to be increased in peripheral neuropathies, provided the maximum M-wave is relatively preserved. Reduced M-wave amplitudes and central facilitation of antidromically-induced reactivation of the anterior horn cells' axon hillocks (F-wave) are believed to contribute to higher F/M-amp ratios. The present study was undertaken to re-evaluate mechanisms responsible for higher F/M-amp ratios in carpal tunnel syndrome (CTS). We enrolled 232 cases affected by CTS and 108 controls...
January 2017: Functional Neurology
https://www.readbyqxmd.com/read/28337957/transplantation-of-cultured-olfactory-bulb-cells-prevents-abnormal-sensory-responses-during-recovery-from-dorsal-root-avulsion-in-the-rat
#4
Andrew Collins, Daqing Li, Stephen B McMahon, Geoffrey Raisman, Ying Li
The central branches of the C7 and C8 dorsal roots were avulsed close to their entry point into the spinal cord in adult rats. The forepaw responses to heat and cold stimuli were tested at 1, 2 and 3 weeks after injury. Over this period the paws were sensitive to both stimuli at 1-2 weeks and returned towards normal at 3 weeks. Immunohistology showed no evidence of axonal regeneration into the spinal cord in a control group of rats with avulsion only, implying that adjacent dorsal roots and their corresponding dermatomes were involved in the recovery...
March 23, 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28264978/deletion-of-the-fractalkine-receptor-cx3cr1-improves-endogenous-repair-axon-sprouting-and-synaptogenesis-after-spinal-cord-injury-in-mice
#5
Camila M Freria, Jodie C E Hall, Ping Wei, Zhen Guan, Dana M McTigue, Phillip G Popovich
Impaired signaling via CX3CR1, the fractalkine receptor, promotes recovery after traumatic spinal contusion injury in mice, a benefit achieved in part by reducing macrophage-mediated injury at the lesion epicenter. Here, we tested the hypothesis that CX3CR1-dependent changes in microglia and macrophage functions also will enhance neuroplasticity, at and several segments below the injury epicenter. New data show that in the presence of inflammatory stimuli, CX3CR1-deficient (CX3CR1(-/-)) microglia and macrophages adopt a reparative phenotype and increase expression of genes that encode neurotrophic and gliogenic proteins...
March 29, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28197201/-three-methods-and-three-points-regulates-p38-mitogen-activated-protein-kinase-in-the-dorsal-horn-of-the-spinal-cord-in-a-rat-model-of-sciatic-nerve-injury
#6
Xin Guo, Tian-Yuan Yu, Wong Steven, Wen-Duan Jia, Chi Ma, Yan-Hong Tao, Chao Yang, Tao-Tao Lv, Shuai Wu, Meng-Qian Lu, Jia-Li Liu
Tuina is a traditional Chinese treatment for sensory disturbances caused by peripheral nerve injury and related diseases. Our previous studies showed that tuina regulates relevant regions and indices of the spinal dorsal horn using the Dian, Bo, and Rou method in Yinmen (BL37), Yanglingquan (GB34), and Weizhong (BL40). Treatment prevents muscle atrophy, protects spinal cord neurons, and promotes sciatic nerve repair. The mechanisms of action of tuina for treating peripheral nerve injury remain poorly understood...
December 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/28040732/mutant-profilin1-transgenic-mice-recapitulate-cardinal-features-of-motor-neuron-disease
#7
Daniel Fil, Abigail DeLoach, Shilpi Yadav, Duah Alkam, Melanie MacNicol, Awantika Singh, Cesar M Compadre, Joseph J Goellner, Charles A O'Brien, Tariq Fahmi, Alexei G Basnakian, Noel Y Calingasan, Jodi L Klessner, Flint M Beal, Owen M Peters, Jake Metterville, Robert H Brown, Karen K Y Ling, Frank Rigo, P Hande Ozdinler, Mahmoud Kiaei
The recent identification of profilin1 mutations in 25 familial ALS cases has linked altered function of this cytoskeleton-regulating protein to the pathogenesis of motor neuron disease. To investigate the pathological role of mutant profilin1 in motor neuron disease, we generated transgenic lines of mice expressing human profilin1 with a mutation at position 118 (hPFN1G118V). One of the mouse lines expressing high levels of mutant human PFN1 protein in the brain and spinal cord exhibited many key clinical and pathological features consistent with human ALS disease...
February 15, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/27814877/a-model-for-radiating-leg-pain-of-endometriosis
#8
Geoffrey M Bove
Endometriosis is a prevalent female health disorder that often leads to back pain and radiating leg pain. Patients with such pain often seek care from multiple health care professionals, including manual therapists. We hypothesized that endometrioma can induce nerve inflammation thus the radiating leg pain that often accompanies endometriosis. To model sciatic endometriosis in female Wistar rats, a section of uterine horn was autotransplanted to the sciatic nerve. Uterus sections with the endometrium removed and autotransplanted to the sciatic nerve served as controls...
October 2016: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/27803784/the-expression-implication-of-gdnf-in-ventral-horn-and-associated-remote-cortex-in-rhesus-monkeys-with-hemisected-spinal-cord-injury
#9
De-Lu Qiu, Ting-Hua Wang
OBJECTIVES: Glial cell line-derived neurotrophic factor (GDNF) can effectively promote axonal regeneration, limit axonal retraction, and produce a statistically significant improvement in motor recovery after spinal cord injury (SCI). However, the role in primate animals with SCI is not fully cognized. MATERIALS AND METHODS: 18 healthy juvenile rhesuses were divided randomly into six groups, observed during the periods of 24 hr, 7 days, 14 days, 1 month, 2 months, and 3 months after T11 hemisecting...
September 2016: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/27776522/inositol-1-4-5-trisphosphate-receptor-type-1-autoantibodies-in-paraneoplastic-and-non-paraneoplastic-peripheral-neuropathy
#10
Sven Jarius, Marius Ringelstein, Jürgen Haas, Irina I Serysheva, Lars Komorowski, Kai Fechner, Klaus-Peter Wandinger, Philipp Albrecht, Harald Hefter, Andreas Moser, Eva Neuen-Jacob, Hans-Peter Hartung, Brigitte Wildemann, Orhan Aktas
BACKGROUND: Recently, we described a novel autoantibody, anti-Sj/ITPR1-IgG, that targets the inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) in patients with cerebellar ataxia. However, ITPR1 is expressed not only by Purkinje cells but also in the anterior horn of the spinal cord, in the substantia gelatinosa and in the motor, sensory (including the dorsal root ganglia) and autonomic peripheral nervous system, suggesting that the clinical spectrum associated with autoimmunity to ITPR1 may be broader than initially thought...
October 24, 2016: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/27600517/assessment-of-motor-units-in-neuromuscular-disease
#11
REVIEW
Robert D Henderson, Pamela A McCombe
The motor unit comprises the anterior horn cell, its axon, and the muscle fibers that it innervates. Although the true number of motor units is unknown, the number of motor units appears to vary greatly between different muscles and between different individuals. Assessment of the number and function of motor units is needed in diseases of the anterior horn cell and other motor nerve disorders. Amyotrophic lateral sclerosis is the most important disease of anterior horn cells. The need for an effective biomarker for assessing disease progression and for use in clinical trials in amyotrophic lateral sclerosis has stimulated the study of methods to measure the number of motor units...
January 2017: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/27452920/acute-flaccid-weakness-with-myelopathy-and-peripheral-nerve-involvement-in-2-children-recent-characterization-of-a-previously-observed-phenomenon
#12
Gemma Olive, Antonia Clarke, Katja Doerholt, Vasantha Gowda, Atta Siddiqui, Ming J Lim
BACKGROUND: Acute flaccid weakness may be the first presentation of acute transverse myelitis (ATM), an immune-mediated central nervous system disorder or may be the first presentation of anterior horn cell syndrome or peripheral nervous system disease. CASE REPORTS: We describe two previously healthy female infants who presented with acute flaccid paralysis and encephalopathy. Neuroimaging revealed central cord signal changes in both cases and surprisingly electrophysiological studies performed revealed a generalized axonal motor neuropathy as well...
November 2016: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/27357294/pathologic-studies-of-fatal-encephalomyelitis-in-children-caused-by-enterovirus-71
#13
Jingjun Xing, Dan Liu, Shu Shen, Zhengyuan Su, Lin Zhang, Yijie Duan, Fang Tong, Yue Liang, Hualin Wang, Fei Deng, Zhihong Hu, Yiwu Zhou
OBJECTIVES: Enterovirus 71 (EV71) is the major pathogen of hand, foot, and mouth disease and can cause death; however, its pathogenesis remains elusive. METHODS: We performed a detailed systematic histopathologic examination and molecular studies on six autopsy cases of EV71 infection using H&E, immunohistochemistry, double immunofluorescence staining, and nested reverse transcription polymerase chain reaction. RESULTS: Characteristic features of acute encephalomyelitis were observed...
July 2016: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/27352608/antennal-lobe-tracts-in-the-noctuid-moth-heliothis-virescens-new-anatomical-findings
#14
Elena Ian, Aleksander Berg, Siri Corneliussen Lillevoll, Bente Gunnveig Berg
As in other insects, three main tracts in the moth brain form parallel connections between the antennal lobe and the protocerebrum. These tracts, which consist of the antennal-lobe projection-neuron axons, target two main areas in the protocerebrum, the calyces of the mushroom bodies and the lateral horn. In spite of the solid neuroanatomical knowledge already established, there are still unresolved issues regarding the antennal-lobe tracts of the moth. One is the proportion of lateral-tract neurons targeting the calyces...
October 2016: Cell and Tissue Research
https://www.readbyqxmd.com/read/27013875/detection-of-hyperphosphorylated-tau-protein-and-%C3%AE-synuclein-in-spinal-cord-of-patients-with-alzheimer-s-disease
#15
Yanjun Guo, Luning Wang, Mingwei Zhu, Honghong Zhang, Yazhuo Hu, Zhitao Han, Jia Liu, Weiqin Zhao, Dexin Wang
The aim of this study was to investigate the neuropathological features of the spinal cord in patients suffering with Alzheimer's disease (AD). Spinal cord tissue collected from three AD patients and eight controls was selected for the study. Data were collected at T2, T8, T10, L4, and S2 spinal levels. The sections were subjected to hematoxylin and eosin and Gallyas-Braak staining methods and then were immunostained with antibodies such as phosphorylated tau protein (AT8), α-synuclein, Aβ, amyloid precursor protein, ubiquitin, and TDP-43...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/26949108/dynamic-secondary-degeneration-in-the-spinal-cord-and-ventral-root-after-a-focal-cerebral-infarction-among-hypertensive-rats
#16
Ge Dang, Xinran Chen, Yicong Chen, Yuhui Zhao, Fubing Ouyang, Jinsheng Zeng
Cerebral infarction can cause secondary damage to nonischemic brain regions. However, whether this phenomenon will appear in central nervous system regions outside the brain remains unclear. Here we investigated pathological changes in the spinal cord and ventral root after ischemic stroke. All rats exhibited apparent neurological deficits post-MCAO, which improved gradually but could still be detected 12-weeks. Neuronal filaments in the corticospinal tract (CST) and neurons in the ventral horn were significantly declined in the contralateral cervical and lumbar enlargement 1-week post-MCAO...
March 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/26882346/a-combined-electrophysiological-and-morphological-study-of-neuropeptide-y-expressing-inhibitory-interneurons-in-the-spinal-dorsal-horn-of-the-mouse
#17
Noboru Iwagaki, Robert P Ganley, Allen C Dickie, Erika Polgár, David I Hughes, Patricia Del Rio, Yulia Revina, Masahiko Watanabe, Andrew J Todd, John S Riddell
The spinal dorsal horn contains numerous inhibitory interneurons that control transmission of somatosensory information. Although these cells have important roles in modulating pain, we still have limited information about how they are incorporated into neuronal circuits, and this is partly due to difficulty in assigning them to functional populations. Around 15% of inhibitory interneurons in laminae I-III express neuropeptide Y (NPY), but little is known about this population. We therefore used a combined electrophysiological/morphological approach to investigate these cells in mice that express green fluorescent protein (GFP) under control of the NPY promoter...
March 2016: Pain
https://www.readbyqxmd.com/read/26843217/comparative-anatomical-distribution-of-neuronal-calcium-binding-protein-necab-1-and-2-in-rodent-and-human-spinal-cord
#18
Ming-Dong Zhang, Swapnali Barde, Edit Szodorai, Anna Josephson, Nicholas Mitsios, Masahiko Watanabe, Johannes Attems, Gert Lubec, Gábor G Kovács, Mathias Uhlén, Jan Mulder, Tibor Harkany, Tomas Hökfelt
Neuronal calcium-binding protein 1 and -2 (NECAB1/2) localize to multiple excitatory neuron populations in the mouse spinal cord. Here, we analyzed rat and human spinal cord, combining in situ hybridization and immunohistochemistry, complementing newly collated data on mouse spinal cord for direct comparisons. Necab1/2 mRNA transcripts showed complementary distribution in rodent's spinal cord. Multiple-labeling fluorescence histochemistry with neuronal phenotypic markers localized NECAB1 to a dense fiber plexus in the dorsal horn, to neurons mainly in superficial layers and to commissural interneurons in both rodent species...
September 2016: Brain Structure & Function
https://www.readbyqxmd.com/read/26819002/axonal-tdp-43-aggregates-in-sporadic-amyotrophic-lateral-sclerosis
#19
T Onozato, A Nakahara, E Suzuki-Kouyama, A Hineno, T Yasude, T Nakamura, H Yahikozawa, M Watanabe, K Kayanuma, H Makishita, S Ohara, T Hashimoto, K Higuchi, T Sakai, K Asano, T Hashimoto, H Kanno, J Nakayama, K Oyanagi
AIMS: Axonal aggregates of phosphorylated (p-) transactive response DNA-binding protein 43 kDa (TDP-43) in sporadic amyotrophic lateral sclerosis (sALS) were examined in relation to propagation of the protein in the nervous system. METHODS: Brains and spinal cords of Japanese patients with sALS and control subjects were examined immunohistochemically using formalin-fixed paraffin-embedded specimens with special reference to the topographical distribution, microscopic features, presynaptic aggregates, and correlation between the aggregates in axons and the clinical course...
October 2016: Neuropathology and Applied Neurobiology
https://www.readbyqxmd.com/read/26709713/spinal-muscular-atrophy-with-respiratory-distress-type-1-smard1-report-of-a-spanish-case-with-extended-clinicopathological-follow-up
#20
Beatriz San Millan, Jose M Fernandez, Carmen Navarro, Alfredo Reparaz, Susana Teijeira
BACKGROUND: Spinal muscular atrophy with respiratory distress type 1 (SMARD1) is a clinically and genetically distinct and uncommon variant of SMA that results from irreversible degeneration of α-motor neurons in the anterior horns of the spinal cord and in ganglion cells on the spinal root ganglia. AIMS: To describe the clinical, electrophysiological, neuropathological, and genetic findings, at different stages from birth to death, of a Spanish child diagnosed with SMARD1...
March 2016: Clinical Neuropathology
keyword
keyword
58625
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"