Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#21
JOURNAL ARTICLE
G Madureira, B Mion, B Van Winters, F Peñagaricano, J Li, E S Ribeiro
Our objectives were to evaluate the endometrial responsiveness of dairy heifers to an intrauterine infusion of recombinant bovine interferon-tau (rbIFN-τ) and to associate endometrial responses to rbIFN-τ with subsequent reproductive performance. In Experiments 1 and 2, cyclic heifers were enrolled in a 5-d CIDR Cosynch program for estrous synchronization, and blood sampling and ultrasonography examinations were performed on d 0, 4, 7, 11, and 14 of the estrous cycle. In Experiment 1, heifers were randomly assigned to receive an intrauterine infusion containing 2 µg of rbIFN-τ (rbIFN-τ = 19) or saline (CTRL = 19) into the uterine horn ipsilateral to the corpus luteum (CL) on d 14 of the estrous cycle...
April 18, 2024: Journal of Dairy Science
#22
JOURNAL ARTICLE
Saima Mumtaz, Najma Baseer, Syed Hamid Habib
UNLABELLED: Preemptive analgesia is used for postoperative pain management, providing pain relief with few adverse effects. In this study, the effect of a preemptive regime on rat behavior and c-fos expression in the spinal cord of the uterine surgical pain model was evaluated. METHOD: It was a lab-based experimental study in which sixty female Sprague-Dawley rats; eight to ten weeks old, weighing 150-300 gm were used. The rats were divided into three main groups: i) Control group (CG), ii) superficial pain group (SG) (with skin incision only), iii) deep pain group (with skin and uterine incisions)...
April 17, 2024: Molecular Pain
#23
JOURNAL ARTICLE
Zheng Fang, Jiaqin Mao, Jialyu Huang, Huijun Sun, Xueyan Lu, Hui Lei, Jie Dong, Shuqiang Chen, Xiaohong Wang
OBJECTIVE: Recurrent pregnancy loss (RPL) patients have higher absolute numbers of decidual natural killer (dNK) cells with elevated intracellular IFN-γ levels leading to a pro-inflammatory cytokine milieu, which contributes to RPL pathogenesis. The main objective of this study was twofold: first to explore the regulatory effects and mechanisms of villus-derived exosomes (vEXOs) from induced abortion patients or RPL patients at the level of intracellular IFN-γ in dNK cells; second to determine the validity of application of vEXOs in the treatment of unexplained RPL (uRPL) through in vitro experiments and mouse models...
April 16, 2024: Cell Communication and Signaling: CCS
#24
JOURNAL ARTICLE
M Imran, Aditya Khandvilkar, Siddhanath Metkari, Geetanjali Sachdeva, Uddhav Chaudhari
Metformin, a well-established anti-diabetic drug, is also used in managing various other metabolic disorders including polycystic ovarian syndrome (PCOS). There are evidences to show that metformin improves endometrial functions in PCOS women. However, fewer studies have explored the direct effects of metformin on endometrium. Previous in vitro studies have shown that therapeutic serum concentrations of metformin enhance endometrial epithelial cell proliferation. The present study was undertaken to investigate in vivo effects of metformin on endometrial proliferation in a rat model of thin endometrium...
June 2024: Clinical and Experimental Pharmacology & Physiology
#25
JOURNAL ARTICLE
Daniel Horn-Ghetko, Linus V M Hopf, Ishita Tripathi-Giesgen, Jiale Du, Sebastian Kostrhon, D Tung Vu, Viola Beier, Barbara Steigenberger, J Rajan Prabu, Luca Stier, Elias M Bruss, Matthias Mann, Yue Xiong, Brenda A Schulman
Ubiquitin ligation is typically executed by hallmark E3 catalytic domains. Two such domains, 'cullin-RING' and 'RBR', are individually found in several hundred human E3 ligases, and collaborate with E2 enzymes to catalyze ubiquitylation. However, the vertebrate-specific CUL9 complex with RBX1 (also called ROC1), of interest due to its tumor suppressive interaction with TP53, uniquely encompasses both cullin-RING and RBR domains. Here, cryo-EM, biochemistry and cellular assays elucidate a 1.8-MDa hexameric human CUL9-RBX1 assembly...
April 11, 2024: Nature Structural & Molecular Biology
#26
JOURNAL ARTICLE
D Marinova, M N Ivanov, T Yamashima, A B Tonchev
The existence of proliferating cells in the intact spinal cord, their distribution and phenotype, are well studied in rodents. A limited number of studies also address the proliferation after spinal cord injury, in non-human primates. However, a detailed description of the quantity, distribution and phenotype of proliferating cells at different anatomical levels of the intact adult non-human primate spinal cord is lacking at present. In the present study, we analyzed normal spinal cord tissues from adult macaque monkeys (Macaca fuscata), infused with Bromo-2'-deoxyuridine (BrdU), and euthanized at 2h, 2 weeks, 5 weeks and 10 weeks after BrdU...
April 15, 2024: Heliyon
#27
JOURNAL ARTICLE
Dan Strohmaier-Nguyen, Carina Horn, Antje J Baeumner
Through enabling whole blood detection in point-of-care testing (POCT), sedimentation-based plasma separation promises to enhance the functionality and extend the application range of lateral flow assays (LFAs). To streamline the entire process from the introduction of the blood sample to the generation of quantitative immune-fluorescence results, we combined a simple plasma separation technique, an immunoreaction, and a micropump-driven external suction control system in a polymer channel-based LFA. Our primary objective was to eliminate the reliance on sample-absorbing separation membranes, the use of active separation forces commonly found in POCT, and ultimately allowing finger prick testing...
April 9, 2024: Analytical and Bioanalytical Chemistry
#28
JOURNAL ARTICLE
Miranda D Horn, Sophia C Forest, Ahmad A Saied, Andrew G MacLean
INTRODUCTION: As the population over the age of 65 increases, rates of neurodegenerative disorders and dementias will rise - necessitating further research into the cellular and molecular mechanisms that contribute to brain aging. With the critical importance of astrocytes to neuronal health and functioning, we hypothesized that alterations in astrocyte expression of aging-associated markers p16INK4a (p16) and sirtuin 1 (SIRT1) with age would correlate with increased rates of neurodegeneration, as measured by FluoroJade C (FJC) staining...
2024: Frontiers in Aging Neuroscience
#29
JOURNAL ARTICLE
Yonggang Hu, Jordan R Crabtree, Anna L M Macagno, Armin P Moczek
BACKGROUND: Nutrient availability is among the most widespread means by which environmental variability affects developmental outcomes. Because almost all cells within an individual organism share the same genome, structure-specific growth responses must result from changes in gene regulation. Earlier work suggested that histone deacetylases (HDACs) may serve as epigenetic regulators linking nutritional conditions to trait-specific development. Here we expand on this work by assessing the function of diverse HDACs in the structure-specific growth of both sex-shared and sex-specific traits including evolutionarily novel structures in the horned dung beetle Onthophagus taurus...
April 5, 2024: EvoDevo
#30
Salvatore Parrillo, Ippolito De Amicis, Roberta Bucci, Jasmine Hattab, Domenico Robbe, Augusto Carluccio
Placental abnormalities more frequently occur during pregnancy of somatic cell clones and may lead to pregnancy loss or dystocia. Adventitious placentation, or diffuse semi-placenta, is determined by the development of areas of accessory placentation between the cotyledons due to the abnormal growth of placentomes.After a full-term pregnancy, a 3-year-old Jersey heifer was referred for dystocia which resulted in the delivery of a dead calf. The cause of dystocia was found to be foetal malposition, while the placenta was physiologically expelled after dystocia resolution...
April 3, 2024: Acta Veterinaria Hungarica
#31
JOURNAL ARTICLE
YiHang Fan, Juan Chen, ChunHui Mou
An electrically tunable pattern-reconfigurable integrated array antenna based on a 1-bit digital coding metasurface is proposed in this paper. The array antenna consists of 8 × 8 unit cells which is divided into the radiation antenna and the phase control metasurface. The rectangular microstrip patch antenna is used as the radiation source. The phase control metasurface includes three stacked layers of square slot units loaded with varactor diodes and a biasing circuit layer. The metasurface regulates the transmission phase of the quasi-plane wave generated by the radiation antenna...
March 11, 2024: Optics Express
#32
JOURNAL ARTICLE
Ehsan Imanbeygi, Mehdi Ahmadi-Boroujeni
In this paper, we present a metallic reflectarray for shaping the emitted Gaussian beam of a 100 GHz horn antenna in reflective and off-axis mode. The proposed reflectarray is a compact planar surface consisting of a 2D array of unit cells with a thin Rogers 5880 substrate. This reflectarray offers advantages over other beam shapers in millimeter-wave (MMW) imaging, as it generates a flat-top beam in off-axis reflective mode and is straightforward to fabricate. To conduct a feasibility study, we first introduce the 1D reflectarray...
March 10, 2024: Applied Optics
#33
JOURNAL ARTICLE
Chiho Kawashima, Hina Hayakawa, Aki Taniguchi, Yusuke Sugimoto, Nobuyuki Kusaba, Norio Yamagishi, Akira Goto
We aimed to evaluate the effects of rumen-protected lysine (RPL) supplementation during the close-up period on uterine involution and the resumption of ovarian function in dairy cows. Fifty-two multiparous Holstein cows were categorized based on parity and expected calving date and randomly assigned to the RPL or control (CON) groups. The RPL group received 80 g of RPL daily from day 21 before the expected calving date until parturition. Blood samples were obtained twice weekly from pre-supplementation to 6 weeks postpartum...
April 2024: Reproduction in Domestic Animals
#34
JOURNAL ARTICLE
Jiancheng Qi, Jing Fang, Fangyuan Huang, Zhiqiang Li, Maqsood Ahmed Kumbhar, Hongrui Guo, Zhihua Ren, Yi Geng, Junliang Deng, Zhicai Zuo
Amputation dehorning (AD) is a common practice performed on calves, causing harmful effects such as pain, distress, anxiety, and fear. These effects extend to behavioral, physiological, and hematological responses, prompting serious ethical concerns regarding animal welfare, even when performed with local anesthesia. Meloxicam, a non-steroidal anti-inflammatory drug, has been widely used to mitigate the side effects of dehorning and disbudding in calves. However, there is a notable gap in research regarding the effects of meloxicam on calves aged 6 weeks to 6 mo undergoing AD procedures...
March 28, 2024: Journal of Dairy Science
#35
JOURNAL ARTICLE
Jie Zeng, Wei-Wei Gao, Hao Yang, Ya-Nang Wang, Yang Mei, Ting-Ting Liu, Min Wang, Li Tang, Dong-Chuan Ma, Wei Li
The spinal cord microglia play a pivotal role in neuroinflammation and neuropathic pain (NP). Sodium tanshinone IIA sulfonate (STS), a derivative of tanshinone IIA, has anti-inflammatory and anti-hyperalgesic effects. However, its underlying mechanism in NP remains unclear. This study aimed to investigate the effect of STS and elucidate possible mechanisms in a rat model of spared nerve injury. In vivo experiments, STS and AG490 were administered intraperitoneally once daily for 14 consecutive days after surgery...
March 27, 2024: European Journal of Pharmacology
#36
JOURNAL ARTICLE
Meiling Zhu, Caroline Zeiss, Mark W Hamrick, Robert S Weinstein, Ben-Hua Sun, Marco Brotto, Xinran Liu, Edwin Siu, Anita Huttner, Steven Tommasini, Christine Simpson, Karl Insogna
PURPOSE: Mitofusin 2 (Mfn2) is one of two mitofusins involved in regulating mitochondrial size, shape and function, including mitophagy, an important cellular mechanism to limit oxidative stress. Reduced expression of Mfn2 has been associated with impaired osteoblast differentiation and function and a reduction in the number of viable osteocytes in bone. We hypothesized that the genetic absence of Mfn2 in these cells would increase their susceptibility to aging-associated metabolic stress, leading to a progressive impairment in skeletal homeostasis over time...
March 27, 2024: Bone
#37
JOURNAL ARTICLE
Vanessa M Monteil, Shane C Wright, Matheus Dyczynski, Max J Kellner, Sofia Appelberg, Sebastian W Platzer, Ahmed Ibrahim, Hyesoo Kwon, Ioannis Pittarokoilis, Mattia Mirandola, Georg Michlits, Stephanie Devignot, Elizabeth Elder, Samir Abdurahman, Sándor Bereczky, Binnur Bagci, Sonia Youhanna, Teodor Aastrup, Volker M Lauschke, Cristiano Salata, Nazif Elaldi, Friedemann Weber, Nuria Monserrat, David W Hawman, Heinz Feldmann, Moritz Horn, Josef M Penninger, Ali Mirazimi
Climate change and population densities accelerated transmission of highly pathogenic viruses to humans, including the Crimean-Congo haemorrhagic fever virus (CCHFV). Here we report that the Low Density Lipoprotein Receptor (LDLR) is a critical receptor for CCHFV cell entry, playing a vital role in CCHFV infection in cell culture and blood vessel organoids. The interaction between CCHFV and LDLR is highly specific, with other members of the LDLR protein family failing to bind to or neutralize the virus. Biosensor experiments demonstrate that LDLR specifically binds the surface glycoproteins of CCHFV...
March 28, 2024: Nature Microbiology
#38
JOURNAL ARTICLE
Md Torikul Islam, Jinjin Cai, Shanena Allen, Denisse G Moreno, Samuel I Bloom, R Colton Bramwell, Jonathan Mitton, Andrew G Horn, Weiquan Zhu, Anthony J Donato, William L Holland, Lisa A Lesniewski
BACKGROUND: Much of what we know about insulin resistance is based on studies from metabolically active tissues such as the liver, adipose tissue, and skeletal muscle. Emerging evidence suggests that the vascular endothelium plays a crucial role in systemic insulin resistance; however, the underlying mechanisms remain incompletely understood. Arf6 (ADP ribosylation factor 6) is a small GTPase that plays a critical role in endothelial cell function. Here, we tested the hypothesis that the deletion of endothelial Arf6 will result in systemic insulin resistance...
March 28, 2024: Arteriosclerosis, Thrombosis, and Vascular Biology
#39
Nan Jiang, Yu-Sheng Yang, Qing-Rong Lin, Yan-Jun Hu, Bin Yu
Although chronic osteomyelitis (COM) affecting the extremities is a frequently occurring disease, the incidence of squamous cell carcinoma (SCC) arising from COM is rare. Consequently, understanding the diagnosis, treatment and prognosis of such a disorder remains limited. In the present study, a case of COM-associated SCC was demonstrated. A 65-year-old woman arrived to the Southern Medical University Nanfang Hospital (Guangzhou, China) with multiple sinus tracts and skin ulcers in the distal part of her left thigh, persisting for over 50 years following an open pierce injury by an ox horn...
May 2024: Biomedical Reports
#40
JOURNAL ARTICLE
Courtney Babb, Henry Badji, Md Taufiqur Rahman Bhuiyan, Jennifer Cornick, Sonia Qureshi, Catherine Sonye, Wagner V Shapiama Lopez, Mehreen Adnan, Hannah E Atlas, Kehkashan Begum, Stephanie A Brennhofer, Bubacarr E Ceesay, Abdoulie K Ceesay, Nigel A Cunliffe, Paul F Garcia Bardales, Shahinur Haque, Bri'Anna Horne, M Jahangir Hossain, Junaid Iqbal, Md Taufiqul Islam, Sadia Islam, Farhana Khanam, Karen L Kotloff, Thandizo Malemia, Katia Manzanares Villanueva, Gertrude Malola Million, Vitumbiko Munthali, John Benjamin Ochieng, Billy Ogwel, Maribel Paredes Olortegui, Richard Omore, Patricia B Pavlinac, James A Platts-Mills, Khandra T Sears, Ousman Secka, Sharon M Tennant, Pablo Peñataro Yori, Mohammad Tahir Yousafzai, Khuzwayo C Jere, Margaret N Kosek, Stephen Munga, Usman N Ikumapayi, Firdausi Qadri, Farah Naz Qamar, Elizabeth T Rogawski McQuade
BACKGROUND: The measurement of fecal inflammatory biomarkers among individuals presenting to care with diarrhea could improve the identification of bacterial diarrheal episodes that would benefit from antibiotic therapy. We reviewed prior literature in this area and describe our proposed methods to evaluate 4 biomarkers in the Enterics for Global Health (EFGH) Shigella surveillance study. METHODS: We systematically reviewed studies since 1970 from PubMed and Embase that assessed the diagnostic characteristics of inflammatory biomarkers to identify bacterial diarrhea episodes...
March 2024: Open Forum Infectious Diseases
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
