keyword
MENU ▼
Read by QxMD icon Read
search

horn cell

keyword
https://www.readbyqxmd.com/read/28938530/cd3xpdl1-bi-specific-t-cell-engager-bite-simultaneously-activates-t-cells-and-nkt-cells-kills-pdl1-tumor-cells-and-extends-the-survival-of-tumor-bearing-humanized-mice
#1
Lucas A Horn, Nicholas G Ciavattone, Ryan Atkinson, Netsanet Woldergerima, Julia Wolf, Virginia K Clements, Pratima Sinha, Munanchu Poudel, Suzanne Ostrand-Rosenberg
Bi-specific T cell engagers (BiTEs) activate T cells through CD3 and target activated T cells to tumor-expressed antigens. BiTEs have shown therapeutic efficacy in patients with liquid tumors; however, they do not benefit all patients. Anti-tumor immunity is limited by Programmed Death 1 (PD1) pathway-mediated immune suppression, and patients who do not benefit from existing BiTES may be non-responders because their T cells are anergized via the PD1 pathway. We have designed a BiTE that activates and targets both T cells and NKT cells to PDL1(+) cells...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28933267/neonatal-plasticity-of-the-nociceptive-system-mechanisms-effects-and-treatment-of-repetitive-painful-procedures-during-nicu-admittance
#2
N J Van den Hoogen, J Patijn, D Tibboel, E A Joosten
INTRODUCTION: In Neonatal Intensive Care Unit (NICU), prematurely born infants undergo a range of skin breaking and painful procedures. At the same time, the spinal nociceptive system is in a sensitive developmental stage. Both neonatal repetitive painful procedures and their treatment can induce plasticity of the neonatal spinal nociceptive system, causing long-lasting alterations to pain processing and pain reactivity. METHODS: This review focuses on developmental processes related to the nociceptive network in the spinal dorsal horn and more specifically at mechanisms related to 1...
September 21, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28927908/the-impact-of-the-standard-american-diet-in-rats-effects-on-behavior-physiology-and-recovery-from-inflammatory-injury
#3
Stacie K Totsch, Tammie L Quinn, Larissa J Strath, Laura J McMeekin, Rita M Cowell, Barbara A Gower, Robert E Sorge
BACKGROUND AND AIMS: Obesity is a significant health concern in the Western world and the presence of comorbid conditions suggests an interaction. The overlapping distributions of chronic pain populations and obesity suggests that an interaction may exist. Poor quality diet (high carbohydrates, saturated fats, omega-6 polyunsaturated fatty acids) can lead to increased adiposity which can activate immune cells independent of the activating effect of the diet components themselves. This dual action can contribute to chronic inflammation that may alter susceptibility to chronic pain and prolong recovery from injury...
September 16, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/28927648/hyperbaric-oxygenation-alleviates-chronic-constriction-injury-cci-induced-neuropathic-pain-and-inhibits-gabaergic-neuron-apoptosis-in-the-spinal-cord
#4
Huiqun Fu, Fenghua Li, Sebastian Thomas, Zhongjin Yang
BACKGROUND AND AIMS: Dysfunction of GABAergic inhibitory controls contributes to the development of neuropathic pain. We examined our hypotheses that (1) chronic constriction injury (CCI)-induced neuropathic pain is associated with increased spinal GABAergic neuron apoptosis, and (2) hyperbaric oxygen therapy (HBO) alleviates CCI-induced neuropathic pain by inhibiting GABAergic neuron apoptosis. METHODS: Male rats were randomized into 3 groups: CCI, CCI+HBO and the control group (SHAM)...
September 15, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/28915316/plate-pattern-clarification-of-the-marine-dinophyte-heterocapsa-triquetra-sensu-stein-dinophyceae-collected-at-the-kiel-fjord-germany
#5
Urban Tillmann, Mona Hoppenrath, Marc Gottschling, Kusber Wolf-Henning, Malte Elbrächter
One of the most common marine dinophytes is a species known as Heterocapsa triquetra. When Stein introduced the taxon Heterocapsa he formally based the type species H. triquetra on the basionym Glenodinium triquetrum. The latter was described by Ehrenberg and is most likely a species of Kryptoperidinium. In addition to that currently unresolved nomenclatural situation, the thecal plate composition of H. triquetra sensu Stein (1883) was controversial in the past. In order to clarify the debate, we collected material and established the strain UTKG7 from the Baltic Sea off Kiel (Germany, the same locality as Stein had studied), which was investigated using light and electron microscopy, and whose systematic position was inferred using molecular phylogenetics...
September 15, 2017: Journal of Phycology
https://www.readbyqxmd.com/read/28913836/female-reproductive-system-morphology-of-crab-eating-fox-cerdocyon-thous-and-cryopreservation-of-genetic-material-for-animal-germplasm-bank-enrichment
#6
L C Machado, K C S Roballo, F S Cury, C E Ambrósio
The sprawl of the urbanization and road network process without building ecological corridors contributes to the high mortality rates and a threat to the population decline of wild species such as the crab-eating fox. A strategy for the ex situ conservation is the study of the reproductive biology of the species and cryopreservation of their genetic heritage through the formation of an animal germplasm bank. This research is in accordance with the principles adopted by Brazilian College of Animal Experimentation...
September 15, 2017: Anatomia, Histologia, Embryologia
https://www.readbyqxmd.com/read/28903471/the-role-of-tgf-%C3%AE-in-the-pathophysiology-of-peritoneal-endometriosis
#7
Vicky J Young, S F Ahmad, W Colin Duncan, Andrew W Horne
BACKGROUND: Endometriosis is estimated to affect 6-10% of women of reproductive age and it is associated with chronic pelvic pain, dysmenorrhoea and subfertility. It is currently managed surgically or medically but symptoms recur in up to 75% of cases and available medical treatments have undesirable side effects. Endometriosis is defined as the presence of endometrial tissue outside the uterus with lesions typically found on the peritoneum. The aetiology of endometriosis is uncertain but there is increasing evidence that transforming growth factor (TGF)-β plays a major role...
September 1, 2017: Human Reproduction Update
https://www.readbyqxmd.com/read/28899975/antagonism-of-eg-vegf-receptors-as-targeted-therapy-for-choriocarcinoma-progression-in-vitro-and-in-vivo
#8
Wael Traboulsi, Frederic Sergent, Houssine Boufettal, Sophie Brouillet, Rima Slim, Pascale Hoffmann, Mohammed Benlahfid, Qun Yong Zhou, Giafranco Balboni, Valentina Onnis, Pierre-Adrien Bolze, Aude Salomon, Philippe Sauthier, François Mallet, Touria Aboussaouira, Jean-Jacques Feige, Mohamed Benharouga, Nadia Alfaidy
PURPOSE: Choriocarcinoma (CC) is the most malignant gestational trophoblastic disease that often develops from complete hydatidiform moles (CHM). Neither the mechanism of CC development nor its progression is yet characterized. We have recently identified EG-VEGF as a novel key placental growth factor that controls trophoblast proliferation and invasion. EG-VEGF acts via two receptors PROKR1 and PROKR2. Here, we demonstrate that EG-VEGF receptors can be targeted for CC therapy. EXPERIMENTAL DESIGN: Three approaches were used, i) a clinical investigation comparing circulating EG-VEGF in Control (n=20) and in distinctive CHM (n=38) and CC (n=9) cohorts, ii) an in vitro study investigating EG-VEGF effects on the CC cell line JEG3, and iii) an in vivo study including the development of a novel CC mouse model, through a direct injection of JEG3-luciferase into the placenta of gravid SCID-mice...
September 12, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28895473/neuroinflammation-in-amyotrophic-lateral-sclerosis-role-of-redox-dys-regulation
#9
Nadia D'Ambrosi, Mauro Cozzolino, Maria Teresa Carrì
SIGNIFICANCE: Amyotrophic lateral sclerosis (ALS) is due to degeneration of upper and lower motor neurons in the anterior horn of the spinal cord and in the motor cortex. Mechanisms leading to motor neuron death are complex and currently the disease is untreatable. Recent Advances. Work in genetic models of ALS indicates that an imbalance in the crosstalk that physiologically exists between motor neurons and the surrounding cells is eventually detrimental to motor neurons. In particular, the cascade of events collectively known as neuroinflammation and mainly characterized by a reactive phenotype of astrocytes and microglia, moderate infiltration of peripheral immune cells and elevated levels of inflammatory mediators has been consistently observed in motor regions of the central nervous system in sporadic and familial ALS, constituting a hallmark of the disease...
September 12, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28895456/spatial-and-cellular-expression-patterns-of-erythropoietin-receptor-and-erythropoietin-during-a-42-day-post-lesional-time-course-after-graded-thoracic-spinal-cord-impact-lesions-in-the-rat
#10
Gesa Cohrs, Stephan Goerden, Ralf Lucius, Michael Synowitz, Maximilian Hubertus Mehdorn, Janka Held-Feindt, Friederike Knerlich-Lukoschus
Erythropoietin (Epo) exhibits promising neuroregenerative potential for spinal cord injury (SCI) and might be involved in other long-term sequelae, such as neuropathic pain development. The current studies investigated the time courses and spatial and cellular patterns of Epo and EpoR expression along the spinal axis after graded SCI. Male Long Evans rats received 100-kdyn, 150-kdyn, and 200-kdyn thoracic (T9) contusions from an Infinite Horizon Impactor. Sham controls received laminectomies. Anatomical and quantitative immunohistochemical analyses of the EpoR/Epo expression along the whole spinal axis were performed 7, 15, and 42 DPO after the lesioning...
September 12, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28889642/treating-pediatric-neuromuscular-disorders-the-future-is-now
#11
REVIEW
James J Dowling, Hernan D Gonorazky, Ronald D Cohn, Craig Campbell
Pediatric neuromuscular diseases encompass all disorders with onset in childhood and where the primary area of pathology is in the peripheral nervous system. These conditions are largely genetic in etiology, and only those with a genetic underpinning will be presented in this review. This includes disorders of the anterior horn cell (e.g., spinal muscular atrophy), peripheral nerve (e.g., Charcot-Marie-Tooth disease), the neuromuscular junction (e.g., congenital myasthenic syndrome), and the muscle (myopathies and muscular dystrophies)...
September 10, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28884921/survival-beyond-the-perinatal-period-expands-the-phenotypes-caused-by-mutations-in-gle1
#12
Edith Said, Jessica X Chong, Maja Hempel, Jonas Denecke, Paul Soler, Tim Strom, Deborah A Nickerson, Christian Kubisch, Michael J Bamshad, Davor Lessel
Mutations in GLE1 underlie Lethal Congenital Contracture syndrome (LCCS) and Lethal Arthrogryposis with Anterior Horn Cell Disease (LAAHD). Both LCCS and LAAHD are characterized by reduced fetal movements, congenital contractures, and a severe form of motor neuron disease that results in fetal death or death in the perinatal period, respectively. We identified bi-allelic mutations in GLE1 in two unrelated individuals with motor delays, feeding difficulties, and respiratory insufficiency who survived beyond the perinatal period...
September 8, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28882951/the-immunoreactivity-of-pi3k-akt-pathway-after-prenatal-hypoxic-damage
#13
Huisun Wang, Yoonyoung Chung, Sun-Kyoung Yu, Yonghyun Jun
BACKGROUND/AIM: There is no consensus on the effect of hypoxia on neurogenesis. In this study, we investigated the immunoreactivity of BDNF and PI3K/Akt signaling after uterine artery ligation in pregnant rats. MATERIALS AND METHODS: Unilateral uterine artery ligation was performed at 16 days of gestation (dg). Fetuses from one horn with ligated artery were allocated to the hypoxic group. Immunohistochemistry was performed with primary antibodies; NeuN, BDNF, PI3K, Akt and phospho-Akt (pAkt)...
September 2017: In Vivo
https://www.readbyqxmd.com/read/28882732/mesenchymal-stem-cells-and-their-conditioned-medium-can-enhance-the-repair-of-uterine-defects-in-a-rat-model
#14
Chi-Hong Ho, Chen-Wei Lan, Chen-Yi Liao, Shih-Chieh Hung, Hsin-Yang Li, Yen-Jen Sung
BACKGROUND: Our aim was to examine the roles of mesenchymal stem cell (MSC) transplantation in the repair of large uterine defects. METHODS: Uterine defects were created in both uterine horns of female rats by a punch instrument, and bone marrow-derived MSCs, MSC-conditioned medium (MSC-CM) or vehicle were injected into the myometrium around the defect. The rate of uterine defect repair was monitored on day 2 and 4 after operation. Cytokine array of MSC-CM was performed, followed by neutralizing antibody experiments to clarify the exact cytokine participating in the MSC-CM-enhanced wound repair...
September 4, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/28882563/adenosine-a1-receptor-potentiated-glycinergic-transmission-in-spinal-cord-dorsal-horn-of-rats-after-peripheral-inflammation
#15
Hu-Hu Bai, Jiang-Ping Liu, Li Yang, Ji-Yuan Zhao, Zhan-Wei Suo, Xian Yang, Xiao-Dong Hu
Adenosine is present at the extracellular space within spinal cord dorsal horn and engaged in the processing of nociceptive sensory signals. Systemic or spinal administration of exogenous adenosine produces a potent analgesia against pathological pain. Here we found that inhibitory glycinergic neurotransmission was an important target for adenosine regulation. In spinal cord slices from intact rats, adenosine increased the inhibitory postsynaptic currents mediated by glycine receptors (GlyRs). In spinal slices from Complete Freund's Adjuvant-injected rats, adenosine potentiated glycinergic transmission to a more degree than in control rats...
September 4, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28880575/from-stem-cell-research-to-three-dimensional-organoids-and-their-applications-in-cancer-research-meeting-report-on-the-9th-international-meeting-of-the-stem-cell-network-north-rhine-westphalia
#16
Samantha Langer, Peter A Horn, Stefan Heinrichs
No abstract text is available yet for this article.
September 7, 2017: Cellular Reprogramming
https://www.readbyqxmd.com/read/28877179/adherence-to-6-mercaptopurine-in-children-and-adolescents-with-acute-lymphoblastic-leukemia
#17
Mervat Alsous, Rana Abu Farha, Eman Alefishat, Suha Al Omar, Deema Momani, Alia Gharabli, James McElnay, Robert Horne, Rawad Rihani
OBJECTIVE: Studies on children with Acute Lymphoblastic Leukemia (ALL) reported non-adherence in 2-54% of cases. The primary objective of this study was to assess rates of adherence to 6-MP using two different methods in children and adolescents with ALL. Secondary aim was to identify factors that influence adherence to 6-MP in children with ALL. METHODS: All eligible children with ALL who are (≤ 19) years old and receive 6-MP therapy for at least 1 month were approached to participate in the study...
2017: PloS One
https://www.readbyqxmd.com/read/28874746/rgma-inhibition-with-human-monoclonal-antibodies-promotes-regeneration-plasticity-and-repair-and-attenuates-neuropathic-pain-after-spinal-cord-injury
#18
Andrea J Mothe, Nardos G Tassew, Alirezha P Shabanzadeh, Romeo Penheiro, Robin J Vigouroux, Lili Huang, Christine Grinnell, Yi-Fang Cui, Emma Fung, Philippe P Monnier, Bernhard K Mueller, Charles H Tator
Traumatic spinal cord injury (SCI) causes a cascade of degenerative events including cell death, axonal damage, and the upregulation of inhibitory molecules which prevent regeneration and limit recovery. Repulsive guidance molecule A (RGMa) is a potent neurite growth inhibitor in the central nervous system, exerting its repulsive activity by binding the Neogenin receptor. Here, we show for the first time that inhibitory RGMa is markedly upregulated in multiple cell types after clinically relevant impact-compression SCI in rats, and importantly, also in the injured human spinal cord...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28874605/ca-2-and-mitochondrial-ros-both-hero-and-villain-in-membrane-repair
#19
REVIEW
Sandra T Cooper
Membrane repair is a symphony of signaling, conducted principally by the steep influx of Ca(2+) through an injured membrane. In this issue of Science Signaling, Horn et al reveal unique interplay between Ca(2+) influx and mitochondrially generated reactive oxygen species (mtROS) to enhance actin-mediated wound closure for survival of injured mammalian muscle and nonmuscle cells.
September 5, 2017: Science Signaling
https://www.readbyqxmd.com/read/28874604/mitochondrial-redox-signaling-enables-repair-of-injured-skeletal-muscle-cells
#20
Adam Horn, Jack H Van der Meulen, Aurelia Defour, Marshall Hogarth, Sen Chandra Sreetama, Aaron Reed, Luana Scheffer, Navdeep S Chandel, Jyoti K Jaiswal
Strain and physical trauma to mechanically active cells, such as skeletal muscle myofibers, injures their plasma membranes, and mitochondrial function is required for their repair. We found that mitochondrial function was also needed for plasma membrane repair in myoblasts as well as nonmuscle cells, which depended on mitochondrial uptake of calcium through the mitochondrial calcium uniporter (MCU). Calcium uptake transiently increased the mitochondrial production of reactive oxygen species (ROS), which locally activated the guanosine triphosphatase (GTPase) RhoA, triggering F-actin accumulation at the site of injury and facilitating membrane repair...
September 5, 2017: Science Signaling
keyword
keyword
58624
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"