keyword
MENU ▼
Read by QxMD icon Read
search

horn cell

keyword
https://www.readbyqxmd.com/read/28107024/the-host-response-in-sepsis-patients-developing-intensive-care-unit-acquired-secondary-infections
#1
Lonneke A van Vught, Maryse A Wiewel, Arie J Hoogendijk, Jos F Frencken, Brendon P Scicluna, Peter M C Klein Klouwenberg, Aeilko H Zwinderman, Rene Lutter, Janneke Horn, Marcus J Schultz, Marc M J Bonten, Olaf L Cremer, Tom van der Poll
RATIONALE: Sepsis can be complicated by secondary infections. We explored the possibility that sepsis patients developing a secondary infection while in the Intensive Care Unit (ICU) display sustained inflammatory, vascular and procoagulant responses. OBJECTIVE: To compare systemic proinflammatory host responses in patients with sepsis who acquire a new infection with those who do not. METHODS: Consecutive sepsis patients with a length of ICU stay >48 hours were prospectively analyzed for the development of ICU-acquired infections...
January 20, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28093371/sonographically-guided-knee-meniscus-injections-feasibility-techniques-and-validation
#2
Michael R Baria, Jacob L Sellon, Dan Lueders, Jay Smith
BACKGROUND: There is a growing interest in the use of biologic agents such as platelet-rich plasma and mesenchymal stem/stromal cells to treat musculoskeletal injuries, including meniscal tears. Although prior research has documented the role of diagnostic ultrasound to evaluate meniscal tears, sonographically guided (SG) techniques to specifically deliver therapeutic agents into the meniscus have not been described. OBJECTIVE: To describe and validate SG injection techniques for the body and posterior horn of the medial and lateral meniscus...
January 13, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28093054/impact-of-psychological-stress-on-pain-perception-in-an-animal-model-of-endometriosis
#3
Siomara Hernandez, Myrella L Cruz, Inevy I Seguinot, Annelyn Torres-Reveron, Caroline B Appleyard
PURPOSE: Pain in patients with endometriosis is considered a significant source of stress but does not always correlate with severity of the condition. We have demonstrated that stress can worsen endometriosis in an animal model. Here, we tested the impact of a psychological stress protocol on pain thresholds and pain receptors. METHODS: Endometriosis was induced in female rats by suturing uterine horn tissue next to the intestinal mesentery. Sham rats had sutures only...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28089350/rickettsia-prowazekii-methionine-aminopeptidase-as-a-promising-target-for-the-development-of-antibacterial-agents
#4
Travis R Helgren, Congling Chen, Phumvadee Wangtrakuldee, Thomas E Edwards, Bart L Staker, Jan Abendroth, Banumathi Sankaran, Nicole A Housley, Peter J Myler, Jonathon P Audia, James R Horn, Timothy J Hagen
Methionine aminopeptidase (MetAP) is a class of ubiquitous enzymes essential for the survival of numerous bacterial species. These enzymes are responsible for the cleavage of N-terminal formyl-methionine initiators from nascent proteins to initiate post-translational modifications that are often essential to proper protein function. Thus, inhibition of MetAP activity has been implicated as a novel antibacterial target. We tested this idea in the present study by targeting the MetAP enzyme in the obligate intracellular pathogen Rickettsia prowazekii...
November 10, 2016: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28088038/evidence-of-functional-duplicity-of-nestin-expression-in-the-adult-mouse-midbrain
#5
Parisa Farzanehfar, Shi Sheng Lu, Anupa Dey, Dharshani Musiienko, Hamzah Baagil, Malcolm K Horne, Tim D Aumann
Whether or not neurogenesis occurs in the adult substantia nigra pars compacta (SNc) is an important question relevant for developing better treatments for the motor symptoms of Parkinson's disease (PD). Although controversial, it is generally believed that dividing cells here remain undifferentiated or differentiate into glia, not neurons. However, there is a suggestion that Nestin-expressing neural precursor cells (NPCs) in the adult SNc have a propensity to differentiate into neurons, which we sought to confirm in the present study...
January 5, 2017: Stem Cell Research
https://www.readbyqxmd.com/read/28062841/metal-based-superoxide-dismutase-and-catalase-mimics-reduce-oxidative-stress-biomarkers-and-extend-life-span-of-saccharomyces-cerevisiae
#6
Thales de P Ribeiro, Fernanda L Fonseca, Mariana D C de Carvalho, Rodrigo M da C Godinho, Fernando Pereira de Almeida, Tatiana D Saint'Pierre, Nicolás A Rey, Christiane Fernandes, Adolfo Horn, Marcos D Pereira
Aging is a natural process characterized by several biological changes. In this context, oxidative stress appears as a key factor that leads cells and organisms to severe dysfunctions and diseases. To cope with reactive oxygen species and oxidative-related damage, there has been increased use of superoxide dismutase (SOD)/catalase (CAT) biomimetic compounds. Recently, we have shown that three metal-based compounds {[Fe(HPClNOL)Cl2]NO3, [Cu(HPClNOL)(CH3CN)](ClO4)2 and Mn(HPClNOL)(Cl)2}, harboring in vitro SOD and/or CAT activities, were critical for protection of yeast cells against oxidative stress...
January 15, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28057535/the-nitric-oxide-donor-isosorbide-dinitrate-induces-a-cephalic-cutaneous-hypersensitivity-associated-with-sensitization-of-the-medullary-dorsal-horn
#7
José María Flores Ramos, Laurent Devoize, Amélie Descheemaeker, Jean-Louis Molat, Philippe Luccarini, Radhouane Dallel
Nitric oxide donors are known to produce headache in healthy as well as migraine subjects, and to induce extracephalic cutaneous hypersensitivity in rodents. However, little is known on the effect of nitric oxide donors on cephalic cutaneous sensitivity. Combining behavioral, immunohistochemical, and in vivo electrophysiological approaches, this study investigated the effect of systemic administration of the nitric oxide donor, isosorbide dinitrate (ISDN), on cephalic and extracephalic cutaneous sensitivity and on neuronal activation within the medullary dorsal horn (MDH) in the rat...
January 3, 2017: Neuroscience
https://www.readbyqxmd.com/read/28048973/effect-of-physical-exercise-and-anabolic-steroid-treatment-on-spinal-motoneurons-and-surrounding-glia-of-wild-type-and-als-mice
#8
Roman M Kassa, Roberta Bonafede, Federico Boschi, Marina Bentivoglio, Raffaella Mariotti
Motoneuron degeneration is the hallmark of amyotrophic lateral sclerosis (ALS). The cause and predisposing factors for sporadic ALS are still unknown. Exposure to a specific environmental risk factors in subjects with a susceptibility genotype may increase the risk of the disease. The role of physical activity and the use of anabolic steroids are still debated in epidemiological studies on patients and murine models of ALS. To assess at the cellular level the role (beneficial or detrimental) of physical exercise and the use of anabolic steroid, we here investigated, in SOD1(G93A) (mSOD1) mice and wild-type littermates, changes in the ventral horn after regular exercise, treatment with the anabolic androgenic steroid 19-nortestosterone (nandrolone), and their combination, compared with matched control sedentary mice...
December 31, 2016: Brain Research
https://www.readbyqxmd.com/read/28040732/mutant-profilin1-transgenic-mice-recapitulate-cardinal-features-of-motor-neuron-disease
#9
Daniel Fil, Abigail DeLoach, Shilpi Yadav, Duah Alkam, Melanie MacNicol, Awantika Singh, Cesar M Compadre, Joseph J Goellner, Charles A O'Brien, Tariq Fahmi, Alexei G Basnakian, Noel Y Calingasan, Jodi L Klessner, M Flint Beal, Owen M Peters, Jake Metterville, Robert H Brown, Karen K Y Ling, Frank Rigo, P Hande Ozdinler, Mahmoud Kiaei
The recent identification of profilin1 mutations in 25 familial ALS cases has linked altered function of this cytoskeleton-regulating protein to the pathogenesis of motor neuron disease. To investigate the pathological role of mutant profilin1 in motor neuron disease, we generated transgenic lines of mice expressing human profilin1 with a mutation at position 118 (hPFN1(G118V)). One of the mouse lines expressing high levels of mutant human PFN1 protein in the brain and spinal cord exhibited many key clinical and pathological features consistent with human ALS disease...
December 30, 2016: Human Molecular Genetics
https://www.readbyqxmd.com/read/28038851/squamous-cell-carcinoma-presenting-as-bird-beak-like-cutaneous-horn
#10
José Francisco Millán-Cayetano, Pablo García-Montero, Magdalena de Troya-Martín
No abstract text is available yet for this article.
December 27, 2016: Medicina Clínica
https://www.readbyqxmd.com/read/28035406/bambi-inhibits-inflammation-through-the-activation-of-autophagy-in-experimental-spinal-cord-injury
#11
Yin Yang, Chunyang Guo, Bo Liao, Junjun Cao, Chen Liang, Xijing He
Autophagy plays an important role in the progression of spinal cord injury (SCI). In this study, we aimed to examine the effects and potential mechanisms of action of BMP and activin membrane-bound inhibitor (BAMBI) in the progression of SCI. A rat model of SCI was established and the rats were injected with pLentiH1-BAMBI shRNA and pAd-BAMBI in the gray and white matter of the spinal cord at T8. After 14 days, motor function evaluation was measured according to the Basso Beattie Bresnahan (BBB) method and the number of motor neuron cell accounts in the anterior horns was measured by Nissl staining...
February 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28035323/the-role-of-pd-l1-expression-and%C3%A2-intratumoral-lymphocytes-in%C3%A2-response%C3%A2-to-perioperative-chemotherapy%C3%A2-for-urothelial-carcinoma
#12
F Erlmeier, A K Seitz, G Hatzichristodoulou, L Stecher, M Retz, J E Gschwend, W Weichert, H R Kübler, T Horn
Introduction: Immunological pathways are relevant for the effectiveness of conventional cytotoxic chemotherapy. Recently, checkpoint inhibition of the PD-1/PD-L1 axis has been shown to be therapeutically relevant in urothelial carcinoma. Objective: To monitor PD-L1 expression on tumor cells and intratumoral infiltration with CD8 positive lymphocytes during perioperative chemotherapy for urothelial cancer and to evaluate their use as potential predictive markers for chemotherapy. Patients and Methods: Sixty-four patients with muscle-invasive urothelial cancer were included in the analysis...
October 27, 2016: Bladder Cancer
https://www.readbyqxmd.com/read/28030475/spinal-intracellular-metabotropic-glutamate-receptor-5-mglur5-contributes-to-pain-and-c-fos-expression-in-a-rat-model-of-inflammatory-pain
#13
Kathleen Vincent, Shu Fan Wang, André Laferrière, Naresh Kumar, Terence J Coderre
Metabotropic glutamate receptor 5 (mGluR5) is an excitatory G-protein coupled receptor present in the spinal cord dorsal horn (SCDH) where it has a well-established role in pain. In addition to its traditional location on the cytoplasmic membrane, recent evidence shows that these receptors are present intracellularly on the nuclear membrane in the SCDH and are implicated in neuropathic pain. Nuclear mGluR5 is a functional receptor that binds glutamate entering the cell through the neuronal glutamate transporter (GT) EAAT3 and activates transcription factor c-fos, whereas plasma membrane mGluR5 is responsible for c-jun activation...
December 26, 2016: Pain
https://www.readbyqxmd.com/read/28027420/sex-differences-in-leukocyte-telomere-length-in-a-free-living-mammal
#14
R L Watson, E J Bird, S Underwood, R V Adams, J Fairlie, K Watt, E Salvo-Chirnside, J G Pilkington, J M Pemberton, T N McNeilly, H Froy, D H Nussey
Mounting evidence suggests that average telomere length reflects previous stress and predicts subsequent survival across vertebrate species. In humans, leukocyte telomere length (LTL) is consistently shorter during adulthood in males than females, although the causes of this sex difference and its generality to other mammals remain unknown. Here we measured LTL in a cross sectional sample of free-living Soay sheep and found shorter telomeres in males than females in later adulthood (>3 years of age), but not in early life...
December 27, 2016: Molecular Ecology
https://www.readbyqxmd.com/read/28017789/driven-by-mutations-the-predictive-value-of-mutation-subtype-in-egfr-mutated-non-small-cell-lung-cancer
#15
REVIEW
Emily Castellanos, Emily Feld, Leora Horn
Epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC) is a genetically heterogeneous disease that includes over 200 distinct mutations. The implications of mutational subtype for both prognostic and predictive value are being increasingly understood. While the most common EGFR mutations-exon 19 deletion or L858R mutations-predict sensitivity to EGFR tyrosine kinase inhibitors (TKIs), it is now being recognized that outcomes may be improved in patients with exon 19 deletions. Additionally, 10% of patients will have an uncommon EGFR mutation, and response to EGFR TKI therapy is highly variable depending upon the mutation...
December 22, 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28008153/pten-mediates-the-cross-talk-between-breast-and-glial-cells-in-brain-metastases-leading-to-rapid-disease-progression
#16
Ina Hohensee, Han-Ning Chuang, Astrid Grottke, Stefan Werner, Alexander Schulte, Stefan Horn, Katrin Lamszus, Kai Bartkowiak, Isabell Witzel, Manfred Westphal, Jakob Matschke, Markus Glatzel, Manfred Jücker, Tobias Pukrop, Klaus Pantel, Harriet Wikman
Despite improvement of therapeutic treatments for breast cancer, the development of brain metastases has become a major limitation to life expectancy for many patients. Brain metastases show very commonly alterations in EGFR and HER2 driven pathways, of which PTEN is an important regulator. Here, we analyzed PTEN expression in 111 tissue samples of breast cancer brain metastases (BCBM). Loss of PTEN was found in a substantial proportion of BCBM samples (48.6%) and was significantly associated with triple-negative breast cancer (67...
December 20, 2016: Oncotarget
https://www.readbyqxmd.com/read/28007937/directed-evolution-of-p450cin-for-mediated-electron-transfer
#17
Ketaki D Belsare, Thomas Horn, Anna Joëlle Ruff, Ronny Martinez, Anders Magnusson, Dirk Holtmann, Jens Schrader, Ulrich Schwaneberg
Directed evolution is a powerful method to optimize enzyme properties for application demands. Interesting targets are P450 monooxygenases which catalyze the stereo- and regiospecific hydroxylation of chemically inert C-H bonds. Synthesis employing P450s under cell-free reaction conditions is limited by low total turnover numbers, enzyme instability, low product yields and the requirement of the expensive co-factor NADPH. Bioelectrocatalysis is an alternative to replace NADPH in cell-free P450-catalyzed reactions...
December 22, 2016: Protein Engineering, Design & Selection: PEDS
https://www.readbyqxmd.com/read/28006031/selection-and-characterization-of-tau-binding-%C3%A1-enantiomeric-peptides-with-potential-for-therapy-of-alzheimer-disease
#18
Christina Dammers, Deniz Yolcu, Laura Kukuk, Dieter Willbold, Marcus Pickhardt, Eckhard Mandelkow, Anselm H C Horn, Heinrich Sticht, Marwa Nidal Malhis, Nadja Will, Judith Schuster, Susanne Aileen Funke
A variety of neurodegenerative disorders, including Alzheimer disease (AD), are associated with neurofibrillary tangles composed of the tau protein, as well as toxic tau oligomers. Inhibitors of pathological tau aggregation, interrupting tau self-assembly, might be useful for the development of therapeutics. Employing mirror image phage display with a large peptide library (over 109 different peptides), we have identified tau fibril binding peptides consisting of d-enantiomeric amino acids. d-enantiomeric peptides are extremely protease stable and not or less immunogenic than l-peptides, and the suitability of d-peptides for in vivo applications have already been demonstrated...
2016: PloS One
https://www.readbyqxmd.com/read/28005131/strain-dependent-glucose-partitioning-in-meniscus-fibrocartilage
#19
Kelsey L Kleinhans, Alicia Jackson
A nearly avascular tissue, the knee meniscus relies on diffusive transport for nutritional supply to cells. Nutrient transport depends on solute partitioning in the tissue, which governs the amount of nutrients that can enter a tissue. The purpose of the present study was to investigate the effects of mechanical strain, tissue region, and tissue composition on the partition coefficient of glucose in meniscus fibrocartilage. A simple partitioning experiment was employed to measure glucose partitioning in porcine meniscus tissues from two regions (horn and central), from both meniscal components (medial and lateral), and at three levels of compression (0%, 10%, and 20%)...
December 22, 2016: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/28004802/targeting-dendritic-cells-to-accelerate-t-cell-activation-overcomes-a-bottleneck-in-tuberculosis-vaccine-efficacy
#20
Kristin L Griffiths, Mushtaq Ahmed, Shibali Das, Radha Gopal, William Horne, Terry D Connell, Kelly D Moynihan, Jay K Kolls, Darrell J Irvine, Maxim N Artyomov, Javier Rangel-Moreno, Shabaana A Khader
The development of a tuberculosis (TB) vaccine that induces sterilizing immunity to Mycobacterium tuberculosis infection has been elusive. Absence of sterilizing immunity induced by TB vaccines may be due to delayed activation of mucosal dendritic cells (DCs), and subsequent delay in antigen presentation and activation of vaccine-induced CD4(+) T-cell responses. Here we show that pulmonary delivery of activated M. tuberculosis antigen-primed DCs into vaccinated mice, at the time of M. tuberculosis exposure, can overcome the delay in accumulation of vaccine-induced CD4(+) T-cell responses...
December 22, 2016: Nature Communications
keyword
keyword
58624
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"