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Agranulocytosis

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https://www.readbyqxmd.com/read/28729050/an-infant-with-concurrent-serotype-6c-invasive-pneumococcal-disease-and-infectious-mononucleosis
#1
Naoko Nishikawa-Nakamura, Takafumi Okada, Keiko Nishimura, Tsuyako Iwai, Kimiko Ubukata, Satoshi Iwata, Asayuki Iwai
Streptococcus pneumoniae is a main causative agent of serious invasive bacterial infections. However, concurrent infection with invasive pneumococcal disease (IPD) and viral infectious mononucleosis (IM) is rare. We report an infant with serotype 6C infection causing IPD occurring simultaneously with IM. A previously healthy 11-month-old girl referred to our hospital because of fever, leukopenia, and elevated C-reactive protein presented to us with disturbance of consciousness, tachycardia, tachypnea and agranulocytosis...
July 17, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28721106/adverse-reactions-in-leprosy-patients-who-underwent-dapsone-multidrug-therapy-a-retrospective-study
#2
Sanjeev Guragain, Namrata Upadhayay, Bishwa Mohan Bhattarai
OBJECTIVE: To investigate the occurrence and clinical characteristics of dapsone-related adverse drug reactions (ADRs) among leprosy patients who underwent multidrug therapy (MDT) from 2010 to 2013 in the western region of Nepal. METHODS: A retrospective review was carried out in the rehabilitation center. Data were collected from the record files of the hospital. RESULTS: From 2010 to 2013, there were 18 patients reported to have dapsone ADRs, with an occurrence rate of 0...
2017: Clinical Pharmacology: Advances and Applications
https://www.readbyqxmd.com/read/28716776/increased-risk-for-thionamide-induced-agranulocytosis-in-elderly-patients-a-case-presentation-and-literature-review
#3
Sumera Bukhari, Muhammad Khan, Naresh Kumar, Vinuta Mohan
Thionamides, such as methimazole and propylthiouracil, are used for the management of hyperthyroidism. Agranulocytosis is a rare adverse effect of thionamides and elderly patients are especially vulnerable. Here we discuss a case of an 80-year-old woman who developed agranulocytosis and pneumonia approximately 4 weeks after starting low dose methimazole therapy. Despite aggressive treatment with broad-spectrum antibiotics and granulocyte colony stimulating factor, she developed multiorgan failure and died. Our goals are to identify risk factors common to elderly patients and hopefully improve outcomes in this population when prescribed thionamides...
July 17, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28715111/identification-of-a-novel-hla-b-allele-hla-b-40-238-in-a-taiwanese-individual
#4
Hui-Lin Lee, Sheng-Kai Lai, Pei-Lung Chen, Chen-Chung Chu
The HLA-B*40:238 allele has one non-synonymous transversion from HLA-B*40:01:01 at nucleotide position 484. The HLA-B*40:238 allele was found in an association study between HLA and antithyroid drug-induced agranulocytosis (1) . The allele, initially genotyped in a Graves' disease patient showed one mismatched nucleotide within the combined sequence pattern of B*40:01:01 and B*13:01:01 using SeCore HLA Sequence-based typing kit (Life Technologies Corporation, WI, USA). To determine which allele the mismatch belonged to, polymerase chain reaction (PCR) was carried out to amplify exon 2 to exon 4 of the HLA-B region with dimorphic forward primers as described by Cereb et al (2) ...
July 17, 2017: HLA
https://www.readbyqxmd.com/read/28669649/-dress-syndrome-and-agranulocytosis-a-rare-combination
#5
P Lavenant, J-M Roue, F Huet, C Abasq, L Misery, S Rioualen
INTRODUCTION: Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe toxidermia that can lead to death from multivisceral failure. We report a case of DRESS associated with febrile agranulocytosis in a child. OBSERVATION: An 8-year-old child was hospitalized for diffuse maculopapular exanthema with edema of the extremities and face associated with cheilitis and febrile agranulocytosis. This symptomatology began 1month after the introduction of carbamazepine for partial epilepsy...
June 29, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28651220/clozapine-versus-other-antipsychotics-during-the-first-18-weeks-of-treatment-a-retrospective-study-on-risk-factor-increase-of-blood-dyscrasias
#6
Michele Fabrazzo, Vincenzo Prisco, Gaia Sampogna, Francesco Perris, Francesco Catapano, Alessio Maria Monteleone, Mario Maj
Blood dyscrasias excluding agranulocytosis received limited attention in antipsychotic-treated patients during the first 18 weeks of therapy, although severe clinical conditions have been reported in a few cases. We extracted data records of 285 Caucasian patients after 18 weeks of antipsychotic treatments to investigate risk factors of blood dyscrasias. We observed a higher risk to develop both transient and persistent anemia, neutrophilia and eosinophilia in clozapine-treated patients, whereas in those treated with other atypical antipsychotics when compared to a reference group under typical antipsychotics, emerged an increased risk for transient neutrophilia and eosinophilia...
June 20, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28592788/levamisole-induced-leukocytoclastic-vasculitis-with-negative-serology-in-a-cocaine-user
#7
Mashal Salehi, Michael P Morgan, Abigail Gabriel
BACKGROUND Levamisole is a common adulterant of cocaine. It can cause agranulocytosis and cutaneous vasculitis that can possibly lead to cutaneous necrosis. In all reported cases of levamisole-induced vasculitis, it has been described as a clinical syndrome characterized by a constellation of typical clinical features and a positive serum serology for ANCA levels, especially very high-titer p-ANCA levels, in the background of cocaine abuse. However, patients may have a negative serology and here, we present the first such case...
June 8, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28590372/changes-in-neutrophil-count-after-antipsychotic-prescription-among-a-retrospective-cohort-of-patients-with-benign-neutropenia
#8
Paul Campion, Gabriel Campion, Deepti Anbarasan
BACKGROUND: There is a paucity of literature regarding the effect of antipsychotics on absolute neutrophil count (ANC) of patients with benign neutropenia (BN). We evaluated the change in ANC after atypical antipsychotic prescription (excluding clozapine) in a retrospective cohort of 22 patients with BN. METHODS/PROCEDURES: Records of all patients with BN who were prescribed antipsychotics and who had ANC measured before and during antipsychotic treatment were obtained from Bronx VA Medical Center between 2005 and 2015 (inclusive)...
August 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28589070/agranulocytosis-sequelae-of-chronic-cocaine-use-case-series-and-literature-review
#9
Roma Srivastava, Maira Rizwan, Muhammad Omer Jamil, Palaniandy Kogulan, Donna Salzman
Agranulocytosis is a rare condition with a reported incidence ranging from one to five cases per million population per year. Most commonly, agranulocytosis is secondary to chemotherapeutic agents, however, other medications have also been associated with it. An immune mediated destruction of circulating granulocytes and/or granulocyte precursors secondary to drug-dependent or drug-induced antibodies is the postulated mechanism. Agranulocytosis has also been reported secondary to recreational drug use...
May 3, 2017: Curēus
https://www.readbyqxmd.com/read/28525589/bone-marrow-involvement-in-systemic-lupus-erythematosus
#10
Emilie Chalayer, Nathalie Costedoat-Chalumeau, Odile Beyne-Rauzy, Jacques Ninet, Stephane Durupt, Jacques Tebib, Bouchra Asli, Olivier Lambotte, Martine Ffrench, Christian Vasselon, Pascal Cathébras
BACKGROUND: Besides peripheral cytopenias, bone marrow abnormalities, such as fibrosis, pure red cell aplasia, and aplastic anemia have been reported in patients with systemic lupus erythematosus (SLE), suggesting that bone marrow may be a target organ in SLE. Our objective was to describe this bone marrow involvement. METHODS: This registry is a nationwide retrospective study. Centers provided data concerning medical history, SLE manifestations, type of hematologic disorder, treatments and outcome...
May 19, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/28488730/octreotide-associated-neutropenia
#11
Stacy S Tse, Troy Kish
Drug-induced neutropenia and agranulocytosis are rare adverse events but can be fatal. Neutropenia can be induced by a myriad of drugs from almost every pharmacologic class. Octreotide is a somatostatin analogue that has been used to treat variceal bleeding, acromegaly, and severe diarrhea associated with metastatic tumors, and to reduce symptoms in the setting of malignant bowel obstruction and pseudo-obstruction. The most common adverse effects associated with octreotide include pain at the injection site and gastrointestinal effects such as loose stools, cramping, and nausea; neutropenia is not currently listed as an adverse effect of the drug...
May 10, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/28486791/rare-nox3-variants-confer-susceptibility-to-agranulocytosis-during-thyrostatic-treatment-of-graves-disease
#12
T S Plantinga, P Arts, G H Knarren, A H Mulder, I M Wakelkamp, A R Hermus, L A Joosten, M G Netea, P H Bisschop, W W de Herder, H J Beijers, I J de Bruin, C Gilissen, J A Veltman, A Hoischen, J W Smit, R T Netea-Maier
Agranulocytosis is a rare and serious adverse effect of antithyroid drugs, with unknown etiology. The present study aimed to uncover genetic susceptibility and underlying mechanisms of antithyroid drug-induced agranulocytosis (ATDAC). We studied two independent families with familial Graves' disease, of which several members developed ATDAC. In addition, six sporadic ATDAC patients with Graves' disease were investigated. Whole exome sequencing analysis of affected and unaffected family members was performed to identify genetic susceptibility variants for ATDAC, followed by functional characterization of primary granulocytes from patients and unrelated healthy controls...
May 9, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28448199/deferiprone-for-the-treatment-of-transfusional-iron-overload-in-thalassemia
#13
REVIEW
Ami Belmont, Janet L Kwiatkowski
Transfusional iron overload can lead to hepatic fibrosis, arrhythmias and congestive heart failure and a number of endocrinopathies. Deferiprone is an oral iron chelator approved for use in the United States as a second line agent for the treatment of transfusional iron overload in patients with thalassemia. Areas covered: This article will review the data regarding the efficacy of deferiprone for iron chelation and prevention and reversal of iron related complications, the drug's adverse effect profile, and the use of this drug in combination regimens...
June 2017: Expert Review of Hematology
https://www.readbyqxmd.com/read/28437295/clozapine-associated-agranulocytosis-treatment-with-granulocyte-colony-stimulating-factor-granulocyte-macrophage-colony-stimulating-factor-a-systematic-review
#14
John Lally, Steffi Malik, Eromona Whiskey, David M Taylor, Fiona P Gaughran, Amir Krivoy, Robert J Flanagan, Aleksandar Mijovic, James H MacCabe
PURPOSE/BACKGROUND: Clozapine is associated with hematological abnormalities, notably neutropenia, which may progress to agranulocytosis. Granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) have been used to reduce the frequency and duration of clozapine-associated neutropenia. This review aims to explore the use, efficacy, and tolerability of these cytokines in the treatment of clozapine-associated agranulocytosis. METHODS/PROCEDURES: We conducted a systematic review of published interventional and observational studies, case series, and case reports where G-CSF/GM-CSF was used to treat clozapine-associated agranulocytosis...
August 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28418011/more-than-25-years-of-genetic-studies-of-clozapine-induced-agranulocytosis
#15
REVIEW
S A J de With, S L Pulit, W G Staal, R S Kahn, R A Ophoff
Clozapine is one of the most effective atypical antipsychotic drugs prescribed to patients with treatment-resistant schizophrenia. Approximately 1% of patients experience potential life-threatening adverse effects in the form of agranulocytosis, greatly hindering its applicability in clinical practice. The etiology of clozapine-induced agranulocytosis (CIA) remains unclear, but is thought to be a heritable trait. We reviewed the genetic studies of CIA published thus far. One recurrent finding from early candidate gene study to more recent genome-wide analysis is that of the involvement of human leukocyte antigen locus...
April 18, 2017: Pharmacogenomics Journal
https://www.readbyqxmd.com/read/28407835/-recurrent-pulmonary-infection-and-oral-mucosal-ulcer
#16
Fei-Mei Kuang, Lan-Lan Tang, Hui Zhang, Min Xie, Ming-Hua Yang, Liang-Chun Yang, Yan Yu, Li-Zhi Cao
An 8-year-old girl who had experienced intermittent cough and fever over a 3 year period, was admitted after experiencing a recurrence for one month. One year ago the patient experienced a recurrent oral mucosal ulcer. Physical examination showed vitiligo in the skin of the upper right back. Routine blood tests and immune function tests performed in other hospitals had shown normal results. Multiple lung CT scans showed pulmonary infection. The patient had recurrent fever and cough and persistent presence of some lesions after anti-infective therapy...
April 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28405135/severe-bone-marrow-suppression-accompanying-pulmonary-infection-and-hemorrhage-of-the-digestive-tract-associated-with-leflunomide-and-low-dose-methotrexate-combination-therapy
#17
Caihong Qu, Ying Lu, Weimin Liu
A 60-year-old male patient developed hyperpyrexia, cough, expectoration with blood-stained sputum, mouth ulcers, and suppurative tonsillitis after receiving 35 days of combination treatment with leflunomide (LEF) and low-dose methotrexate (MTX) for active rheumatoid arthritis. On admission, routine blood tests showed severe thrombocytopenia, agranulocytosis, and decreased hemoglobin concentration compared with the relatively normal results of 1 month previously during the first hospitalization. Chest radiography revealed inflammation in both lungs, and a fecal occult blood test was positive...
January 2017: Journal of Pharmacology & Pharmacotherapeutics
https://www.readbyqxmd.com/read/28403560/icons-in-paediatrics-rolf-kostmann-1909-1982
#18
Carl Gustaf Ljunggren, Lars Stenhammar, Leif Strömberg
No abstract text is available yet for this article.
July 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28392335/graves-disease-in-a-3-year-old-patient-with-agranulocytosis-due-to-anti-thyroid-drugs-radioiodine-ablation-therapy-as-an-effective-alternative
#19
E Espinosa-Muñoz, D Ramírez-Ocaña, A M Martín-García, F J Ruiz-García, C Puentes-Zarzuela
The case is presented of a 3 year-old girl with mitochondrial disease (subacute necrotizing encephalomyelopathy of Leigh syndrome), v-stage chronic kidney disease of a diffuse mesangial sclerosis, as well as developmental disorders, and diagnosed with hyperthyroidism Graves-Basedow disease. Six weeks after starting the treatment with neo-carbimazole, the patient reported a serious case of agranulocytosis. This led to stopping the anti-thyroid drugs, and was treated successfully with (131)I ablation therapy...
July 2017: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/28371438/agranulocytosis-and-mixed-type-autoimmune-hemolytic-anemia-in-primary-sj%C3%A3-gren-s-syndrome-a-case-report-and-review-of-the-literature
#20
Lin Qiao, Jing Chen, Xiao-Mei Leng, Wen Zhang, Bing Han, Yan Zhao, Xiao-Feng Zeng
Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease that presents with sicca symptoms of the main mucosal surfaces. Patients with pSS have a broad spectrum of laboratory features, such as cytopenias and hypergammaglobulinemia. Although hematological abnormalities are usually seen in pSS patients, agranulocytosis and autoimmune hemolytic anemia (AIHA) are rare. Here we describe a 40-year-old woman with pSS who developed both agranulocytosis and mixed-type AIHA. An increased risk of malignancies has also been reported in pSS patients with hematological changes...
December 2016: International Journal of Rheumatic Diseases
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