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lgr5 inner ear

Yanping Zhang, Yan Chen, Wenli Ni, Luo Guo, Xiaoling Lu, Liman Liu, Wen Li, Shan Sun, Lei Wang, Huawei Li
The Wnt/β-catenin signaling pathway plays important roles in mammalian inner ear development. Lgr5, one of the downstream target genes of the Wnt/β-catenin signaling pathway, has been reported to be a marker for inner ear hair cell progenitors. Lgr6 shares approximately 50% sequence homology with Lgr5 and has been identified as a stem cell marker in several organs. However, the detailed expression profiles of Lgr6 have not yet been investigated in the mouse inner ear. Here, we first used Lgr6-EGFP-Ires-CreERT2 mice to examine the spatiotemporal expression of Lgr6 protein in the cochlear duct during embryonic and postnatal development...
2015: Frontiers in Cellular Neuroscience
Tian Wang, Renjie Chai, Grace S Kim, Nicole Pham, Lina Jansson, Duc-Huy Nguyen, Bryan Kuo, Lindsey A May, Jian Zuo, Lisa L Cunningham, Alan G Cheng
Recruitment of endogenous progenitors is critical during tissue repair. The inner ear utricle requires mechanosensory hair cells (HCs) to detect linear acceleration. After damage, non-mammalian utricles regenerate HCs via both proliferation and direct transdifferentiation. In adult mammals, limited transdifferentiation from unidentified progenitors occurs to regenerate extrastriolar Type II HCs. Here we show that HC damage in neonatal mouse utricle activates the Wnt target gene Lgr5 in striolar supporting cells...
2015: Nature Communications
Renjie Chai, Bryan Kuo, Tian Wang, Eric J Liaw, Anping Xia, Taha A Jan, Zhiyong Liu, Makoto M Taketo, John S Oghalai, Roeland Nusse, Jian Zuo, Alan G Cheng
Inner ear hair cells are specialized sensory cells essential for auditory function. Previous studies have shown that the sensory epithelium is postmitotic, but it harbors cells that can behave as progenitor cells in vitro, including the ability to form new hair cells. Lgr5, a Wnt target gene, marks distinct supporting cell types in the neonatal cochlea. Here, we tested the hypothesis that Lgr5(+) cells are Wnt-responsive sensory precursor cells. In contrast to their quiescent in vivo behavior, Lgr5(+) cells isolated by flow cytometry from neonatal Lgr5(EGFP-CreERT2/+) mice proliferated and formed clonal colonies...
May 22, 2012: Proceedings of the National Academy of Sciences of the United States of America
Renjie Chai, Anping Xia, Tian Wang, Taha Adnan Jan, Toshinori Hayashi, Olivia Bermingham-McDonogh, Alan Gi-Lun Cheng
The Wnt signaling pathway is a recurring theme in tissue development and homeostasis. Its specific roles during inner ear development are just emerging, but few studies have characterized Wnt target genes. Lgr5, a member of the G protein-coupled receptor family, is a Wnt target in the gastrointestinal and integumentary systems. Although its function is unknown, its deficiency leads to perinatal lethality due to gastrointestinal distension. In this study, we used a knock-in reporter mouse to examine the spatiotemporal expression of Lgr5 in the cochlear duct during embryonic and postnatal periods...
August 2011: Journal of the Association for Research in Otolaryngology: JARO
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