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https://www.readbyqxmd.com/read/28918295/case-report-primary-aortosigmoid-fistula-a-rare-cause-of-lower-gastrointestinal-bleeding
#1
Chirin Khalaf, Kim C Houlind
INTRODUCTION: A primary aortoenteric fistula (PAEF) is a communication between aorta and the gastrointestinal tract. It is a rare condition that is difficult to diagnose and therefore associated with a high mortality. PRESENTATION OF CASE: We report a rare case of a 66-year old man with an unstable bleeding PAEF. A salvage procedure was performed with a covered stent. Later, a sigmoidectomy was performed with resection of the fistula. Postoperatively, the patient suffered an infection that was treated well with antibiotics and he was discharged two weeks later with complete resolution of the fistula...
September 2, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28910968/efficiency-of-antibody-therapy-in-demyelinating-diseases
#2
Tetsuya Akaishi, Ichiro Nakashima
Monoclonal antibody therapy is a new treatment strategy for many types of diseases including cancers and autoimmune diseases, realizing a high efficacy and tolerability. In multiple sclerosis (MS) and neuromyelitis optica (NMO) spectrum disorders, several monoclonal antibodies have been suggested to decrease the incidence of clinical relapse and the disease activity. In MS, anti-α4 integrin (natalizumab), anti-CD52 (alemtuzumab), anti-CD25 (daclizumab) and anti-CD20 (ocrelizumab) have been shown to effectively reduce the relapses in randomized controlled trials and have been approved by the Food and Drug Administration...
July 1, 2017: International Immunology
https://www.readbyqxmd.com/read/28882772/early-elective-versus-delayed-elective-surgery-in-acute-recurrent-diverticulitis-a-systematic-review-and-meta-analysis
#3
REVIEW
Rao Muhammad Asaf Khan, Shahin Hajibandeh, Shahab Hajibandeh
OBJECTIVES: To investigate outcomes of early versus delayed surgery in patients with acute recurrent diverticulitis. METHODS: We performed a systematic review in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement standards. We conducted a search of electronic information sources, including MEDLINE; EMBASE; CINAHL; the Cochrane Central Register of Controlled Trials (CENTRAL); the World Health Organization International Clinical Trials Registry; ClinicalTrials...
September 4, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28877787/acute-sigmoid-diverticulitis-presenting-as-necrotizing-fasciitis-of-the-thigh-and-retroperitoneum
#4
Nathan Eric Smith, Mark McKenney
No abstract text is available yet for this article.
November 1, 2016: American Surgeon
https://www.readbyqxmd.com/read/28875302/laparoscopic-approaches-to-complicated-diverticulitis
#5
REVIEW
M Gachabayov, R Essani, R Bergamaschi
BACKGROUND: The objective of this article is to review the evolving role of laparoscopic surgery in the treatment of complicated diverticulitis. PURPOSE: The authors attempted to give readers a concise insight into the evidence available in the English language literature. This study does not offer a systematic review of the topic, rather it highlights the role of laparoscopy in the treatment of complicated diverticulitis. CONCLUSIONS: New level 1 evidence suggest that observation rather than elective resection following nonoperative management of diverticulitis with abscess and/or extraluminal air is not below the standard of care...
September 5, 2017: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/28871308/-laparoscopic-lavage-for-perforated-sigmoid-diverticulitis-one-year-results-of-the-scandiv-trial
#6
J Reibetanz, C T Germer
No abstract text is available yet for this article.
September 4, 2017: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/28863081/12-months-results-of-laparoscopic-lavage-in-perforated-acute-diverticulitis-update-of-meta-analysis-results-new-evidences-which-perspectives
#7
Marco Ceresoli, Federico Coccolini, Luca Ansaloni
No abstract text is available yet for this article.
August 31, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28862055/elastotic-lesions-of-intestinal-subserosal-fat-report-of-two-cases
#8
Aaron R Huber, Raul S Gonzalez
We report 2 unusual elastotic lesions of intestinal subserosal fat. The first arose in the small bowel subserosa of a 64-year-old woman with volvulus. It was undetected macroscopically and consisted of a relatively circumscribed focus of elastosis, with essentially no evidence of fibrosis or blood vessel walls within. The second arose in the subserosa of the sigmoid colon in a 46-year-old woman with recurrent diverticulitis. It was also undetected macroscopically and consisted of a well-circumscribed nodule of elastic fibers surrounding prominent veins and arteries...
August 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28861417/impact-of-diverticular-inflammation-and-complication-assessment-classification-on-the-burden-of-medical-therapies-in-preventing-diverticular-disease-complications-in-italy
#9
Antonio Tursi, Walter Elisei, Marcello Picchio, Gabriella Nasi, Angela Maria Mastromatteo, Francesco Di Mario, Enrico Di Rosa, Maria Alessandra Brandimarte, Giovanni Brandimarte
BACKGROUND: Several treatments are currently advised to manage diverticular disease (DD) patients, but their impact on the burden of the disease is unknown. Our aim was to assess the economic analysis of using the recent Diverticular Inflammation and Complication Assessment (DICA) endoscopic classification on the burden of medical therapies prescribed in preventing DD complications occurrence in Italy. METHODS: We assessed retrospectively the cost/year of treatments in estimated DICA 1, DICA 2 and DICA 3 population...
August 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28857901/two-unique-cases-of-ciprofloxacin-associated-avulsion-of-ligament-and-tendon
#10
Jeffrey David Smith, Robert W Irwin, Erin T Wolff
Ciprofloxacin is recognized to have a deleterious relationship with tendons, particularly Achilles tendinopathy, which makes up most case reports. Tendinopathy seems to occur because of induction of collagen-degrading enzymes causing damage and ischemia of the poorly vascularized regions preventing repair. The focus on the relationship of ciprofloxacin and the Achilles tendon leaves patients on fluoroquinolones with non-Achilles tendinopathy symptoms at risk of misdiagnosis. There have not been any documented instances of ligament damage with ciprofloxacin administration in the literature, although ligament and tendon compositions are similar and should have similar susceptibility...
August 25, 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28846501/rapid-source-control-laparotomy-is-there-a-mortality-benefit
#11
James Vogler, Laura Bagwell, Leslie Hart, Sharon Holmes, Jason Sciaretta, John Mihran Davis
BACKGROUND: The purpose of this study was to determine the influence rapid source-control laparotomy (RSCL) has on the mortality rate in non-trauma patients with intra-abdominal infection. The hypothesis was that RSCL reduces deaths and hospital lengths of stay (LOS) in patients compared with definitive repair and primary fascial closure (PFC). METHODS: The International Classification of Diseases-10 codes for sepsis, gastric and duodenal ulcer perforation or hemorrhage, incisional or ventral hernia with obstruction, intestinal volvulus, ileus with obstruction, diverticulitis with perforation or abscess, vascular disorder of intestine, non-traumatic intestinal perforation, peritoneal abscess, and unspecified peritonitis were used to query the 2015 National Surgical Quality Improvement Project (NSQIP) database for all patients treated with either RSCL or PFC...
August 28, 2017: Surgical Infections
https://www.readbyqxmd.com/read/28837412/recurrence-of-colonic-diverticulitis-identifying-predictive-ct-findings-retrospective-cohort-study
#12
Elliot C Dickerson, Suzanne T Chong, James H Ellis, Kuanwong Watcharotone, Bin Nan, Matthew S Davenport, Mahmoud Al-Hawary, Michael B Mazza, Rafat Rizk, Arden M Morris, Richard H Cohan
Purpose To identify computed tomographic (CT) findings that are predictive of recurrence of colonic diverticulitis. Materials and Methods Institutional review board approval was obtained for this HIPAA-compliant, retrospective cohort study. Six abdominal fellowship-trained radiologists reviewed the CT studies of 440 consecutive subjects diagnosed with acute colonic diverticulitis between January 2004 and May 2008 to determine the involved segments, maximum wall thickness in the inflamed segment, severity of diverticulosis, presence of complications (abscess, fistula, stricture, or perforation), and severity of the inflammation...
August 24, 2017: Radiology
https://www.readbyqxmd.com/read/28834452/reminiscing-on-remnants-imaging-of-meckel-diverticulum-and-its-complications-in-adults
#13
Argha Chatterjee, Carla Harmath, Camila Lopes Vendrami, Nancy A Hammond, Pardeep Mittal, Riad Salem, Frank H Miller
OBJECTIVE: Meckel diverticulum may become symptomatic if it is complicated by hemorrhage, intestinal obstruction, diverticulitis, or tumor. Although classically described in children, it is often missed in adults because of lack of suspicion and difficulty in detection. The purpose of this article is to review the imaging findings and management of Meckel diverticulum and its complications. CONCLUSION: Although it is infrequently encountered incidentally, Meckel diverticulum should be considered especially when interpreting examinations for abdominal pain, small-bowel obstruction, and gastrointestinal bleeding...
August 23, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28817406/idiopathic-myointimal-hyperplasia-of-mesenteric-veins-an-uncommon-cause-of-ischemic-colitis-with-distinct-mucosal-features
#14
Rhonda K Yantiss, Isabelle Cui, Nicole C Panarelli, Jose Jessurun
Idiopathic myointimal hyperplasia of mesenteric veins causes chronic ischemic mucosal injury with segmental strictures that mimic inflammatory bowel disease and nonocclusive ischemic colitis. It is characterized by myointimal proliferative changes that narrow the lumina of veins combined with ischemic injury and ulcers. Most cases reported to date have been diagnosed following surgical resection. The aim of this study was to determine whether mucosal changes of idiopathic myointimal hyperplasia of mesenteric veins are sufficiently sensitive and specific to allow its recognition in biopsy material...
August 15, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28815036/bacterial-stimuli-activate-nitric-oxide-colonic-mucosal-production-in-diverticular-disease-protective-effects-of-l-casei-dg%C3%A2-lactobacillus-paracasei-cncm-i-1572
#15
Fabio Turco, Paolo Andreozzi, Ilaria Palumbo, Francesco Paolo Zito, Martina Cargiolli, Walter Fiore, Nicola Gennarelli, Giovanni Domenico De Palma, Giovanni Sarnelli, Rosario Cuomo
BACKGROUND: Micro-inflammation and changes in gut microbiota may play a role in the pathogenesis of diverticular disease (DD). OBJECTIVE: The objective of this article is to evaluate the expression of nitric oxide (NO)-related mediators and S100B in colonic mucosa of patients with DD in an ex vivo model of bacterial infection. METHODS: Intestinal biopsies obtained from patients with diverticulosis, symptomatic uncomplicated diverticular disease (SUDD) and SUDD with previous acute diverticulitis (SUDD+AD) were stimulated with the probiotic L...
August 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28814777/the-microbial-ecosystem-distinguishes-chronically-diseased-tissue-from-adjacent-tissue-in-the-sigmoid-colon-of-chronic-recurrent-diverticulitis-patients
#16
Kathleen M Schieffer, Kate Sabey, Justin R Wright, David R Toole, Rebecca Drucker, Vasily Tokarev, Leonard R Harris, Sue Deiling, Melanie A Eshelman, John P Hegarty, Gregory S Yochum, Walter A Koltun, Regina Lamendella, David B Stewart
Diverticular disease is commonly associated with the older population in the United States. As individual's age, diverticulae, or herniation of the mucosa through the colonic wall, develop. In 10-25% of individuals, the diverticulae become inflamed, resulting in diverticulitis. The gut ecosystem relies on the interaction of bacteria and fungi to maintain homeostasis. Although bacterial dysbiosis has been implicated in the pathogenesis of diverticulitis, associations between the microbial ecosystem and diverticulitis remain largely unstudied...
August 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28808771/multicentre-controlled-randomized-clinical-trial-to-compare-the-efficacy-and-safety-of-ambulatory-treatment-of-mild-acute-diverticulitis-without-antibiotics-with-the-standard-treatment-with-antibiotics
#17
Laura Mora Lopez, Neus Ruiz-Edo, Sheila Serra Pla, Anna Pallisera Llovera, Salvador Navarro Soto, Xavier Serra-Aracil
PURPOSE: Acute diverticulitis (AD) is a highly prevalent disease in Spain. Its chronic-recurrent appearance and high rate of relapse mean that it has a major epidemiological and economic impact on our health system. In spite of this, it has not been studied in any great depth. Reassessing its etiopathology, recent studies have observed that it is an inflammatory disease-not, as classic theories had postulated, an infectious one. In the light of these findings, the suitability of antibiotics for its treatment has been reconsidered...
August 14, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28806761/transcriptome-analysis-of-pdgfr%C3%AE-cells-identifies-t-type-ca2-channel-cacna1g-as-a-new-pathological-marker-for-pdgfr%C3%AE-cell-hyperplasia
#18
Se Eun Ha, Moon Young Lee, Masaaki Kurahashi, Lai Wei, Brian G Jorgensen, Chanjae Park, Paul J Park, Doug Redelman, Kent C Sasse, Laren S Becker, Kenton M Sanders, Seungil Ro
Platelet-derived growth factor receptor alpha (PDGFRα)+ cells are distributed into distinct morphological groups within the serosal, muscular, and submucosal layers as well as the myenteric and deep muscular plexi. PDGFRα+ cells directly interact with interstitial cells of Cajal (ICC) and smooth muscle cells (SMC) in gastrointestinal smooth muscle tissue. These three cell types, SMC, ICC, and PDGFRα+ cells (SIP cells), form an electrical syncytium, which dynamically regulates gastrointestinal motility. We have previously reported the transcriptomes of SMC and ICC...
2017: PloS One
https://www.readbyqxmd.com/read/28799055/risk-factors-for-complicated-diverticulitis-systematic-review-and-meta-analysis
#19
REVIEW
H E Bolkenstein, B J M van de Wall, E C J Consten, I A M J Broeders, W A Draaisma
PURPOSE: The aim of this systematic review is to identify risk factors that can predict complicated diverticulitis. Uncomplicated diverticulitis is a self-limiting and mild disease, but 10% of patients with diverticulitis develop complications requiring further treatment. It is important to estimate the risk of developing complicated diverticulitis at an early stage to set the right treatment at initial presentation. METHODS: Embase, MEDLINE, and Cochrane databases were searched for studies reporting on risk factors for complicated diverticulitis...
August 10, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28797339/do-patients-mandate-resection-after-a-first-episode-of-acute-diverticulitis-of-the-colon-with-a-complication
#20
REVIEW
Ryan Francis Bendl, Roberto Bergamaschi
No abstract text is available yet for this article.
September 2017: Advances in Surgery
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