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https://www.readbyqxmd.com/read/28092931/the-criteria-of-metabolic-syndrome-and-national-health-checkup-and-education-system-in-japan
#1
Kazumasa Yamagishi, Hiroyasu Iso
Two major definitions of metabolic syndrome have been proposed. One focuses on accumulation of risk factors such as the American Heart Association (AHA) and National Heart, Lung and Blood Institute (NHLBI) criteria; and the other focuses on abdominal obesity such as the International Diabetes Federation (IDF) and Japanese criteria. The latter consider waist circumference as an obligatory component, whereas the former does not. In 2009, the IDF, NHLBI, AHA and the other organizations attempted to unify these criteria, and waist circumference is no longer an obligatory component...
January 6, 2017: Epidemiology and Health
https://www.readbyqxmd.com/read/28092913/umbilical-venous-catheter-malposition-is-associated-with-necrotizing-enterocolitis-in-premature-infants
#2
Mustafa Sulemanji, Khashayar Vakili, David Zurakowski, Wayne Tworetzky, Steven J Fishman, Heung Bae Kim
OBJECTIVE: The etiology of necrotizing enterocolitis (NEC) remains elusive despite known associations with several factors, including intestinal ischemia related to the effects of umbilical arterial catheterization on the mesenteric circulation. However, the role of the mesenteric venous circulation has yet to be studied as a potential cause of NEC. We examined the association between umbilical venous catheter (UVC) position and the development of NEC in premature infants. DESIGN: A prospective cohort study was performed to examine the effect of UVC on portosystemic shunting via the ductus venosus (DV) and its potential role in NEC...
January 17, 2017: Neonatology
https://www.readbyqxmd.com/read/28092861/a-deafening-flash-visual-interference-of-auditory-signal-detection
#3
Christopher Fassnidge, Claudia Cecconi Marcotti, Elliot Freeman
In some people, visual stimulation evokes auditory sensations. How prevalent and how perceptually real is this? 22% of our neurotypical adult participants responded 'Yes' when asked whether they heard faint sounds accompanying flash stimuli, and showed significantly better ability to discriminate visual 'Morse-code' sequences. This benefit might arise from an ability to recode visual signals as sounds, thus taking advantage of superior temporal acuity of audition. In support of this, those who showed better visual relative to auditory sequence discrimination also had poorer auditory detection in the presence of uninformative visual flashes, though this was independent of awareness of visually-evoked sounds...
January 13, 2017: Consciousness and Cognition
https://www.readbyqxmd.com/read/28092860/design-synthesis-and-biological-evaluation-of-quinazoline-phosphoramidate-mustard-conjugates-as-anticancer-drugs
#4
Songwen Lin, Yingbo Li, Yufen Zheng, Laichun Luo, Qi Sun, Zemei Ge, Tieming Cheng, Runtao Li
A series of novel compounds with phosphoramide mustard functionality incorporated into the quinazoline scaffold of EGFR/HER2 inhibitors were designed and synthesized as multi-target-directed ligands against tumor cells. In vitro assays showed that tumor cell lines with high HER2 level were more sensitive to the compounds than tumor cells with low HER2 level. Compound 10d (EMB-3) was one of the most potent inhibitors with IC50 of 7.4 nM and 82 nM against EGFR and HER2, respectively. The mechanism studies were also supported by the effect of 10d-induced DNA damage in MDA-MB-468 cells...
January 3, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28092819/silver-nanoparticles-supported-over-mesoporous-alumina-as-an-efficient-nanocatalyst-for-n-alkylation-of-hetero-aromatic-amines-and-aromatic-amines-using-alcohols-as-alkylating-agent
#5
Priyanka Paul, Piyali Bhanja, Noor Salam, Usha Mandi, Asim Bhaumik, Seikh Mafiz Alam, Sk Manirul Islam
We have successfully embedded rhombohedral crystallites of silver nanoparticles (Ag-NPs) over mesoporous alumina (Ag@Al2O3) material for the first time. The Ag@Al2O3 has been characterized by powder X-ray diffraction (PXRD), ultra high resolution transmission electron microscopy (UHR-TEM), scanning electron microscopy (SEM), N2 adsorption/desorption isotherm, Fourier transform infrared spectroscopy (FT-IR), ultraviolet-visible absorption spectra (UV-Vis), and thermogravimetric analysis (TGA). The PXRD confirms the presence of the rhombohedral phase of Ag nanoparticles...
January 3, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28092814/a-participatory-action-research-study-exploring-women-s-understandings-of-the-concept-of-informed-choice-during-pregnancy-and-childbirth-in-ireland
#6
Denise O'Brien, Michelle M Butler, Mary Casey
OBJECTIVE: to explore women's understandings and definitions of the concept of informed choice during pregnancy and childbirth. METHODS: a three-phase action research approach. In the first phase of the study (reported in this paper), fifteen women were interviewed to establish their understandings and experiences of informed choice. SETTING: Dublin, Ireland in a large maternity hospital. PARTICIPANTS: fifteen postnatal women who gave birth to a live healthy infant, women attended obstetric or midwifery-led care...
January 4, 2017: Midwifery
https://www.readbyqxmd.com/read/28092792/curiosity-improves-coping-efficacy-and-reduces-suicidal-ideation-severity-among-military-veterans-at-risk-for-suicide
#7
Lauren M Denneson, Derek J Smolenski, Nigel E Bush, Steven K Dobscha
Curiosity, the tendency to engage in novel and challenging opportunities, may be an important source of resilience for those at risk for suicide. We hypothesized that curiosity would have a buffering effect against risk conferred by multiple sources of distress, whereby curiosity would be associated with reduced suicidal ideation and increased coping efficacy. As part of a larger intervention trial designed to improve coping skills and reduce suicidal ideation, 117 military veterans with suicidal ideation completed measures of curiosity and distress (perceived stress, depression, anxiety, and sleep disturbances) at baseline, and completed measures of suicidal ideation and coping efficacy (to stop negative thoughts, to enlist support from friends and family) at baseline and 3-, 6-, and 12-week follow up...
January 9, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28092781/social-consequences-of-subclinical-negative-symptoms-an-emg-study-of-facial-expressions-within-a-social-interaction
#8
Marcel Riehle, Tania M Lincoln
BACKGROUND AND OBJECTIVES: The negative symptoms of schizophrenia are related to lower social functioning even in non-clinical samples, but little is known about the distinct social consequences of motivational and expressive negative symptoms. In this study we focused on expressive negative symptoms and examined how these symptoms and varying degrees of pro-social facial expressiveness (smiling and mimicry of smiling) relate to the social evaluations by face-to-face interaction partners and to social support...
January 10, 2017: Journal of Behavior Therapy and Experimental Psychiatry
https://www.readbyqxmd.com/read/28092777/controlling-the-3d-architecture-of-self-lifting-auto-generated-tissue-equivalents-slates-for-optimized-corneal-graft-composition-and-stability
#9
Ricardo M Gouveia, Elena González-Andrades, Juan C Cardona, Carmen González-Gallardo, Ana M Ionescu, Ingrid Garzon, Miguel Alaminos, Miguel González-Andrades, Che J Connon
Ideally, biomaterials designed to play specific physical and physiological roles in vivo should comprise components and microarchitectures analogous to those of the native tissues they intend to replace. For that, implantable biomaterials need to be carefully designed to have the correct structural and compositional properties, which consequently impart their bio-function. In this study, we showed that the control of such properties can be defined from the bottom-up, using smart surface templates to modulate the structure, composition, and bio-mechanics of human transplantable tissues...
December 23, 2016: Biomaterials
https://www.readbyqxmd.com/read/28092774/the-lonely-road-to-paranoia-a-path-analytic-investigation-of-loneliness-and-paranoia
#10
Fabian Lamster, Tania M Lincoln, Clara M Nittel, Winfried Rief, Stephanie Mehl
Loneliness and paranoia are related, but the mechanisms that link them to each other remain unclear. Systematic reviews on loneliness propose a social-cognitive model in which loneliness leads to negative evaluations of other persons and a lack of interpersonal trust. However, the data discussed in these reviews are based on healthy individuals. Building on this model, the present study investigated 1) whether negative interpersonal schemata mediate the association between loneliness and paranoia and 2) whether a low level of perceived social support and less frequent social contact are related to loneliness...
January 2, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28092763/growth-and-antioxidant-defense-responses-of-wheat-seedlings-to-di-n-butyl-phthalate-and-di-2-ethylhexyl-phthalate-stress
#11
Minling Gao, Youming Dong, Ze Zhang, Wenhua Song, Yun Qi
Phthalate acid esters (PAEs) are vital environmental hormone-like chemicals that are noxious to plants, animals, and human beings. In this study, the influences of di-n-butyl phthalate (DBP) and di (2-ethylhexyl) phthalate (DEHP) on the seed germination, root morphology, and various physiological changes of wheat seedlings were investigated by analyzing superoxide anion (O2(-)) accumulation, antioxidant enzyme activity, and lipid peroxidation. DBP and DEHP were found to obviously inhibit germination only at high concentrations, but significantly affected root morphology even at lower concentrations...
January 5, 2017: Chemosphere
https://www.readbyqxmd.com/read/28092760/serum-brain-derived-neurotrophic-factor-and-stability-of-depressive-symptoms-in-coronary-heart-disease-patients-a-prospective-study
#12
Stella L Kuhlmann, Mira Tschorn, Volker Arolt, Katja Beer, Julia Brandt, Laura Grosse, Wilhelm Haverkamp, Jacqueline Müller-Nordhorn, Nina Rieckmann, Johannes Waltenberger, Katharina Warnke, Rainer Hellweg, Andreas Ströhle
OBJECTIVE: Brain-derived neurotrophic factor (BDNF) supports neurogenesis, angiogenesis, and promotes the survival of various cell types in the brain and the coronary system. Moreover, BDNF is associated with both coronary heart disease (CHD) and depression. The current study aims to investigate whether serum BDNF levels are associated with the course of depressive symptoms in CHD patients. METHODS: At baseline, N=225 CHD patients were enrolled while hospitalized...
December 23, 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28092754/public-participation-gis-for-improving-wood-burning-emissions-from-residential-heating-and-urban-environmental-management
#13
Susana López-Aparicio, Matthias Vogt, Philipp Schneider, Maarit Kahila-Tani, Anna Broberg
A crowdsourcing study supported by a public participation GIS tool was designed and carried out in two Norwegian regions. The aim was to improve the knowledge about emissions from wood burning for residential heating in urban areas based on the collection of citizens' localized insights. We focus on three main issues: 1) type of dwelling and residential heating source; 2) wood consumption and type of wood appliances; and 3) citizens' perception of the urban environment. Our study shows the importance of wood burning for residential heating, and of the resulted particle emissions, in Norwegian urban areas...
January 13, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28092747/ecological-control-line-a-decade-of-exploration-and-an-innovative-path-of-ecological-land-management-for-megacities-in-china
#14
Wuyang Hong, Chengyun Yang, Liuxin Chen, Fangfang Zhang, Shaoqing Shen, Renzhong Guo
Ecological control line is a system innovation in the field of ecological environment protection in China and it has become as an important strategy of national ecological protection. Ten years have passed since the first ecological control line in Shenzhen was delimited in 2005. This study examines the connotations of ecological control line and the current study status in China and abroad, and then takes a brief description about the delimitation background and existing problems of the ecological control line in Shenzhen...
January 13, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28092741/waste-to-energy-ash-monofill-mining-an-environmental-characterization-of-recovered-material
#15
Justin G Roessler, Timothy G Townsend, Abhimanyu Kanneganti
Samples of combined bottom and fly ash produced at a U.S. waste-to-energy facility were collected from an ash monofill. These samples represented ash monofilled between 1991 and 2008. The ash samples were characterized for total element content and leachability; trends in these parameters were evaluated as a function of sample depth and ash age. Comparison to risk thresholds was used to assess the relative magnitude of the total and leachable mass of elements in the monofilled ash. Natural carbonation was found to have occurred in the monofilled ash, reducing the pH and leachability of Al and Pb...
January 9, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28092738/hearing-children-s-voices-including-children-s-perspectives-on-their-experiences-of-domestic-violence-in-welfare-reports-prepared-for-the-english-courts-in-private-family-law-proceedings
#16
Gillian S Macdonald
This research examined Children and Family Court Advisory and Support Service (Cafcass) reports prepared for private family court proceedings in domestic violence cases in England. The research found that in cases where children's accounts identified them as victims of violence, these disclosures regularly disappeared from report recommendations. Particular discourses regarding 'child welfare' and 'contact' were identified, which routinely impacted on the ways in which children's voices were taken into account...
January 13, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28092704/x-ray-reflectivity-study-of-interaction-of-an-imidazolium-based-ionic-liquid-with-soft-supported-lipid-membrane
#17
Gourav Bhattacharya, Rajendra P Giri, Himani Saxena, Ved Varun Agrawal, Ashish Gupta, Mrinmay Kumar Mukhopadhyay, Sajal Kumar Ghosh
Ionic liquids (ILs) are important for their antimicrobial activity and are found to be toxic to some of the micro-organisms. To shed light on the mechanism of their activities, the interaction of an imidazolium-based IL 1-butyl-3-methylimidazolium tetrfluroborate ([BMIM][BF4]) with E-coli bacteria and cell membrane mimicking lipid mono- and bi-layers have been studied. The survival of the bacteria and corresponding growth inhibition are observed to be a function of concentration of the IL. The IL alters the pressure area isotherm of the monolayer formed at air-water interface by the lipid 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC)...
January 16, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28092685/precision-oncology-for-acute-myeloid-leukemia-using-a-knowledge-bank-approach
#18
Moritz Gerstung, Elli Papaemmanuil, Inigo Martincorena, Lars Bullinger, Verena I Gaidzik, Peter Paschka, Michael Heuser, Felicitas Thol, Niccolo Bolli, Peter Ganly, Arnold Ganser, Ultan McDermott, Konstanze Döhner, Richard F Schlenk, Hartmut Döhner, Peter J Campbell
Underpinning the vision of precision medicine is the concept that causative mutations in a patient's cancer drive its biology and, by extension, its clinical features and treatment response. However, considerable between-patient heterogeneity in driver mutations complicates evidence-based personalization of cancer care. Here, by reanalyzing data from 1,540 patients with acute myeloid leukemia (AML), we explore how large knowledge banks of matched genomic-clinical data can support clinical decision-making. Inclusive, multistage statistical models accurately predicted likelihoods of remission, relapse and mortality, which were validated using data from independent patients in The Cancer Genome Atlas...
January 16, 2017: Nature Genetics
https://www.readbyqxmd.com/read/28092678/6-phosphofructo-2-kinase-fructose-2-6-biphosphatase-4-is-essential-for-p53-null-cancer-cells
#19
S Ros, J Flöter, I Kaymak, C Da Costa, A Houddane, S Dubuis, B Griffiths, R Mitter, S Walz, S Blake, A Behrens, K M Brindle, N Zamboni, M H Rider, A Schulze
The bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-4 (PFKFB4) controls metabolic flux through allosteric regulation of glycolysis. Here we show that p53 regulates the expression of PFKFB4 and that p53-deficient cancer cells are highly dependent on the function of this enzyme. We found that p53 downregulates PFKFB4 expression by binding to its promoter and mediating transcriptional repression via histone deacetylases. Depletion of PFKFB4 from p53-deficient cancer cells increased levels of the allosteric regulator fructose-2,6-bisphosphate, leading to increased glycolytic activity but decreased routing of metabolites through the oxidative arm of the pentose-phosphate pathway...
January 16, 2017: Oncogene
https://www.readbyqxmd.com/read/28092666/loss-of-%C3%AE-opioid-receptor-signaling-in-nociceptors-but-not-microglia-abrogates-morphine-tolerance-without-disrupting-analgesia
#20
Gregory Corder, Vivianne L Tawfik, Dong Wang, Elizabeth I Sypek, Sarah A Low, Jasmine R Dickinson, Chaudy Sotoudeh, J David Clark, Ben A Barres, Christopher J Bohlen, Grégory Scherrer
Opioid pain medications have detrimental side effects including analgesic tolerance and opioid-induced hyperalgesia (OIH). Tolerance and OIH counteract opioid analgesia and drive dose escalation. The cell types and receptors on which opioids act to initiate these maladaptive processes remain disputed, which has prevented the development of therapies to maximize and sustain opioid analgesic efficacy. We found that μ opioid receptors (MORs) expressed by primary afferent nociceptors initiate tolerance and OIH development...
January 16, 2017: Nature Medicine
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