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https://www.readbyqxmd.com/read/28820059/histone-modifications-in-aging%C3%AF-the-underlying-mechanisms-and-implications
#1
Yuan Wang, Quan Yuan, Liang Xie
Aging is characterized by time-dependent functional decline, which results in the reduced ability to cope with physiological challenges. The aging process can be affected by genetic factors, environment factors, epigenetic factors, and several stochastic factors. Epigenetic marker alteration during aging has been widely monitored and studied recently, since these epigenetic alterations are theoretically reversible. Histone post-translational modifications have been found to play a crucial role in epigenetic alteration during aging, among which histone methylation and histone acetylation are emerging as two well-documented modification methods...
August 17, 2017: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28813287/marital-satisfaction-and-divorce-in-couples-in-stepfamilies
#2
REVIEW
Anita DeLongis, Amy Zwicker
We review research and theory examining stress and coping in stepfamilies as predictors of marital quality and divorce. Although the divorce rate in first-marriages has stabilized after years of increase in North America, the divorce rate of remarriages continues to increase. We argue that depression and marital distress are both mechanisms through which stepfamily stress impacts marital stability, with parenting stressors particularly potent determinants of divorce. We draw upon our own research predicting divorce across 20 years in 112 married couples in stepfamilies, as well as from the larger literature on stepfamilies...
February 2017: Current Opinion in Psychology
https://www.readbyqxmd.com/read/28813256/parenting-and-hiv
#3
REVIEW
Tamsen Rochat, Elena Netsi, Stephanie Redinger, Alan Stein
With the widespread use of antiretroviral therapy and successful prevention of mother-to-child transmission the development of HIV-negative children with HIV-positive parents has become an important focus. There is considerable evidence that children's developmental risk is heightened because a parental HIV-diagnosis is associated with a range of potential problems such as depression, stigma and financial difficulties. Up to a third of children in sub-Saharan Africa (SSA) are cared for by an HIV-positive parent or caregiver...
June 2017: Current Opinion in Psychology
https://www.readbyqxmd.com/read/28813187/twelve-steps-two-factors-coping-strategies-moderate-the-association-between-craving-and-daily-12-step-use-in-a-college-recovery-community
#4
Richard P Wiebe, Amanda M Griffin, Yao Zheng, Kitty S Harris, H Harrington Cleveland
BACKGROUND: Affiliating with 12-step groups appears to reduce relapse risk. By relying on between-person designs, extant research has been unable to examine daily mechanisms through which 12-step group affiliation contributes to recovery. OBJECTIVES: To examine the daily use and factor structure of the 12 steps and intrapersonal predictors and moderators of 12-step use. To determine whether the 12 steps were used in response to daily craving and, if so, which steps and in what contexts...
August 16, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28812746/redox-titration-of-gold-and-platinum-surface-oxides-at-porous-microelectrodes
#5
Mareike Haensch, Julian Behnken, Luis Balboa, Alexander Dyck, Gunther Wittstock
The extension of the surface interrogation mode of scanning electrochemical microscopy (SI-SECM) is demonstrated for porous electrode materials. These materials are often high surface area powders which are very important electrocatalysts for instance in fuel cells or water electrolyzers. The powdered electrocatalyst material is filled into a cavity-microelectrode which is then operated as the sample electrode in SECM. After a surface oxide generation step, the oxides on the porous sample are reduced by [Ru(NH3)6](2+) formed at the microelectrode probe of the SECM while the sample is at open circuit potential...
August 16, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28808127/the-components-of-the-unique-zur-regulon-of-cupriavidus-metallidurans-mediate-cytoplasmic-zinc-handling
#6
Lucy Bütof, Christopher Schmidt-Vogler, Martin Herzberg, Cornelia Große, Dietrich H Nies
Zinc is an essential trace element and at the same time it is toxic at high concentrations. In the beta-proteobacterium Cupriavidus metallidurans the highly efficient removal of surplus zinc from the periplasm is responsible for its outstanding metal resistance. Rather than having a typical Zur-dependent, high-affinity ATP-binding cassette transporter of the ABC protein superfamily for zinc uptake at low concentrations, C. metallidurans instead has the secondary zinc importer ZupT of the ZRT/IRT (ZIP) family...
August 14, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28807423/coping-with-the-stress-in-the-cardiac-intensive-care-unit-can-mindfulness-be-the-answer
#7
Nadya Golfenshtein, Janet A Deatrick, Amy J Lisanty, Barbara Medoff-Cooper
BACKGROUND: Mothers of infants with complex congenital heart disease are exposed to increased stress which has been associated with numerous adverse health outcomes. The coping mechanisms these mothers use critically effect the familial illness adaptation and most likely infant outcomes. Currently no data-based strategies have been developed for mothers to facilitate their coping, and proactively promote their adaptation in the critical care settings. A potential strategy is mindfulness which is currently used in other clinical settings with stress-reduction effects...
August 11, 2017: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/28806582/beck-s-cognitive-theory-and-the-response-style-theory-of-depression-in-adolescents-with-and-without-mild-to-borderline-intellectual-disability
#8
Martine M Weeland, Karin S Nijhof, R Otten, Ignace P R Vermaes, Jan K Buitelaar
AIM: This study tests the validity of Beck's cognitive theory and Nolen-Hoeksema's response style theory of depression in adolescents with and without MBID. METHODS: The relationship between negative cognitive errors (Beck), response styles (Nolen-Hoeksema) and depressive symptoms was examined in 135 adolescents using linear regression. RESULTS: The cognitive error 'underestimation of the ability to cope' was more prevalent among adolescents with MBID than among adolescents with average intelligence...
August 11, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/28805432/strain-dependent-sex-differences-in-a-long-term-forced-swim-paradigm
#9
José Colom-Lapetina, Sabrina L Begley, Megan E Johnson, Kristina J Bean, Whitney N Kuwamoto, Rebecca M Shansky
Women are twice as likely as men to suffer from trauma- and stressor-related disorders. The development of improved therapeutic interventions is contingent upon a more complete grasp of both the neural and behavioral dynamics of the stress response in females. The rodent forced swim test (FST) is a valuable animal model for exploring the neurobiological mechanisms responsible for selection of active and passive responses to inescapable stressors, but it is often neglected in 2-day FST studies is the dissociation of innate (Day 1) versus learned (Day 2) coping responses...
August 14, 2017: Behavioral Neuroscience
https://www.readbyqxmd.com/read/28805306/bioprocess-scale-up-down-as-integrative-enabling-technology-from-fluid-mechanics-to-systems-biology-and-beyond
#10
Frank Delvigne, Ralf Takors, Rob Mudde, Walter van Gulik, Henk Noorman
Efficient optimization of microbial processes is a critical issue for achieving a number of sustainable development goals, considering the impact of microbial biotechnology in agrofood, environment, biopharmaceutical and chemical industries. Many of these applications require scale-up after proof of concept. However, the behaviour of microbial systems remains unpredictable (at least partially) when shifting from laboratory-scale to industrial conditions. The need for robust microbial systems is thus highly needed in this context, as well as a better understanding of the interactions between fluid mechanics and cell physiology...
August 14, 2017: Microbial Biotechnology
https://www.readbyqxmd.com/read/28804382/positive-messages-enhance-older-adults-motivation-and-recognition-memory-for-physical-activity-programmes
#11
Nanna Notthoff, Peter Klomp, Friederike Doerwald, Susanne Scheibe
Although physical activity is an effective way to cope with ageing-related impairments, few older people are motivated to turn their sedentary lifestyle into an active one. Recent evidence suggests that walking can be more effectively promoted in older adults with positive messages about the benefits of walking than with negative messages about the risks of inactivity. This study examined motivation and memory as the supposed mechanisms underlying the greater effectiveness of positively framed compared to negatively framed messages for promoting activity...
September 2016: European Journal of Ageing
https://www.readbyqxmd.com/read/28802433/a-survey-of-the-prevalence-of-fatigue-its-precursors-and-individual-coping-mechanisms-among-u-s-manufacturing-workers
#12
Lin Lu, Fadel M Megahed, Richard F Sesek, Lora A Cavuoto
Advanced manufacturing has resulted in significant changes on the shop-floor, influencing work demands and the working environment. The corresponding safety-related effects, including fatigue, have not been captured on an industry-wide scale. This paper presents results of a survey of U.S. manufacturing workers for the: prevalence of fatigue, its root causes and significant factors, and adopted individual fatigue coping methods. The responses from 451 manufacturing employees were analyzed using descriptive data analysis, bivariate analysis and Market Basket Analysis...
November 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/28802275/response-of-methylocystis-sp-strain-sc2-to-salt-stress-physiology-global-transcriptome-and-amino-acid-profiles
#13
Dongfei Han, Hannes Link, Werner Liesack
Soil microorganisms have to rapidly respond to salt-induced osmotic stress. Type II methanotrophs of the genus Methylocystis are widely distributed in upland soils, but are known to have a low salt tolerance. Here, we tested the ability of Methylocystis sp. strain SC2 to adapt to increased salinity. When exposed to 0.75% NaCl, methane oxidation was completely inhibited for 2.25 h and fully recovered within 6 h. Growth was inhibited for 23.5 h and then fully recovered. Its transcriptome was profiled after 0 min (control), 45 min (early response) and 14 h (late response) of stress exposure...
August 11, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28801107/nanoprecipitation-process-from-encapsulation-to-drug-delivery
#14
REVIEW
Claudia Janeth Martínez Rivas, Mohamad Tarhini, Waisudin Badri, Karim Miladi, Hélène Greige-Gerges, Qand Agha Nazari, Sergio Arturo Galindo Rodríguez, Rocío Álvarez Román, Hatem Fessi, Abdelhamid Elaissari
Drugs encapsulation is a suitable strategy in order to cope with the limitations of conventional dosage forms such as unsuitable bioavailability, stability, taste, and odor. Nanoprecipitation technique has been used in the pharmaceutical and agricultural research as clean alternative for other drug carrier formulations. This technique is based on precipitation mechanism. Polymer precipitation occurs after the addition of a non-solvent to a polymer solution in four steps mechanism: supersaturation, nucleation, growth by condensation, and growth by coagulation that leads to the formation of polymer nanoparticles or aggregates...
August 8, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28800518/the-implications-of-drought-and-water-conservation-on-the-reuse-of-municipal-wastewater-recognizing-impacts-and-identifying-mitigation-possibilities
#15
Quynh K Tran, David Jassby, Kurt A Schwabe
As water agencies continue to investigate opportunities to increase resilience and local water supply reliability in the face of drought and rising water scarcity, water conservation strategies and the reuse of treated municipal wastewater are garnering significant attention and adoption. Yet a simple water balance thought experiment illustrates that drought, and the conservation strategies that are often enacted in response to it, both likely limit the role reuse may play in improving local water supply reliability...
July 27, 2017: Water Research
https://www.readbyqxmd.com/read/28799474/-caught-between-a-rock-and-a-hard-place-between-discourses-of-empowerment-and-solicitude-danish-public-sector-service-professionals-discourses-of-nonattendance
#16
Michaela Hoej, Katrine Schepelern Johansen, Birgitte Ravn Olesen, Sidse Marie Arnfred
Nonattendance constitutes a profound challenge in public sector services targeting young adults with mental health difficulties. Therefore, researchers and practitioners are occupied with trying to resolve this. For clinicians to be aware of their own naturalized and perhaps inappropriate communicative practices, we investigated the established normative organizational logics behind explanations and strategies related to nonattendance. We performed a critical discourse analysis on material collected through participatory research throughout 2015...
September 2017: Qualitative Health Research
https://www.readbyqxmd.com/read/28798754/isoprene-responses-and-functions-in-plants-challenged-by-environmental-pressures-associated-to-climate-change
#17
REVIEW
Alessio Fini, Cecilia Brunetti, Francesco Loreto, Mauro Centritto, Francesco Ferrini, Massimiliano Tattini
The functional reasons for isoprene emission are still a matter of hot debate. It was hypothesized that isoprene biosynthesis evolved as an ancestral mechanism in plants adapted to high water availability, to cope with transient and recurrent oxidative stresses during their water-to-land transition. There is a tight association between isoprene emission and species hygrophily, suggesting that isoprene emission may be a favorable trait to cope with occasional exposure to stresses in mesic environments. The suite of morpho-anatomical traits does not allow a conservative water use in hygrophilic mesophytes challenged by the environmental pressures imposed or exacerbated by drought and heat stress...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28797581/surviving-stress-modulation-of-atf4-mediated-stress-responses-in-normal-and-malignant-cells
#18
REVIEW
Inge M N Wortel, Laurens T van der Meer, Michael S Kilberg, Frank N van Leeuwen
Activating transcription factor 4 (ATF4) is a stress-induced transcription factor that is frequently upregulated in cancer cells. ATF4 controls the expression of a wide range of adaptive genes that allow cells to endure periods of stress, such as hypoxia or amino acid limitation. However, under persistent stress conditions, ATF4 promotes the induction of apoptosis. Recent advances point to a role for post-translational modifications (PTMs) and epigenetic mechanisms in balancing these pro- and anti-survival effects of ATF4...
August 7, 2017: Trends in Endocrinology and Metabolism: TEM
https://www.readbyqxmd.com/read/28794171/a-study-of-the-relationship-between-resilience-burnout-and-coping-strategies-in-doctors
#19
R Scott McCain, Nicola McKinley, Martin Dempster, W Jeffrey Campbell, Stephen J Kirk
PURPOSE OF THE STUDY: The aim of this study was to measure resilience, coping and professional quality of life in doctors. STUDY DESIGN: A cross-sectional study using an online questionnaire in a single National Health Service trust, including both primary and secondary care doctors. RESULTS: 283 doctors were included. Mean resilience was 68.9, higher than population norms. 100 (37%) doctors had high burnout, 194 (72%) doctors had high secondary traumatic stress and 64 (24%) had low compassion satisfaction...
August 9, 2017: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/28794023/tumor-suppressor-p53-stimulates-the-expression-of-epstein-barr-virus-latent-membrane-protein-1
#20
Qianli Wang, Amy Lingel, Vicki Geiser, Zachary Kwapnoski, Luwen Zhang
Epstein-Barr virus (EBV) is associated with multiple human malignancies. EBV latent membrane protein 1 (LMP1) is required for the efficient transformation of primary B lymphocytes in vitro and possibly in vivo The tumor suppressor p53 plays a seminal role in cancer development. In some EBV-associated cancers, p53 tends to be wild-type and overly expressed, however, the effects of p53 on LMP1 expression is not clear. We find LMP1 expression is associated with p53 expression in EBV-transformed cells under physiological and DNA damaging conditions...
August 9, 2017: Journal of Virology
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