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https://www.readbyqxmd.com/read/29909089/safety-of-laparoscopic-surgery-for-benign-diseases-during-pregnancy-a-nationwide-retrospective-cohort-study
#1
Daisuke Shigemi, Shotaro Aso, Hiroki Matsui, Kiyohide Fushimi, Hideo Yasunaga
STUDY OBJECTIVE: To compare fetal, maternal, and operative outcomes of laparoscopic surgery versus laparotomy for major benign diseases including appendicitis, cholecystitis, adnexal masses, and uterine myoma during pregnancy. DESIGN: Retrospective cohort study (Canadian Task Force classification II-2). SETTING: The Diagnosis Procedure Combination database, a national inpatient database for acute-care inpatients in Japan. PATIENTS: 6,018 eligible patients underwent abdominal surgery (4,047 laparotomy and 1,971 laparoscopy patients) from July 2010 through March 2016...
June 14, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29901641/spontaneous-postnatal-complete-resolution-of-an-antenatally-diagnosed-fetal-hepatic-cyst-a-case-report
#2
Denis Mihai Serban, Costela Serban, Dan Navolan, Ioan Sas
RATIONALE: Antenatal diagnosis of a fetal hepatic cyst is rare. Since in most cases the lesion is treated after birth by surgery only a few reports present a complete spontaneous resolution of an antenatally diagnosed hepatic cyst. PATIENT CONCERNS: A single hepatic cyst (1.34/1.47 cm) was diagnosed in a fetus at 36 weeks of pregnancy while mother was in labor. After an uneventful vaginal birth, a multidisciplinary evaluation of the newborn confirmed the presence of the cyst...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29901247/joint-contracture-is-reduced-by-intra-articular-implantation-of-rosiglitazone-loaded-hydrogels-in-a-rabbit-model-of-arthrofibrosis
#3
Diren Arsoy, Christopher G Salib, William H Trousdale, Meagan E Tibbo, Afton K Limberg, Anthony Viste, Eric A Lewallen, Nicolas Reina, Michael J Yaszemski, Daniel J Berry, Andre J van Wijnen, Mark E Morrey, Joaquin Sanchez-Sotelo, Matthew P Abdel
Trauma, surgery, and other inflammatory conditions can lead to debilitating joint contractures. Adjunct pharmacologic modalities may permit clinical prevention and treatment of recalcitrant joint contractures. We investigated the therapeutic potential of rosiglitazone by intra-articular delivery via oligo[poly(ethylene glycol)fumarate] (OPF) hydrogels in an established rabbit model of arthrofibrosis. OPF hydrogels loaded with rosiglitazone were characterized for drug elution properties upon soaking in minimum essential media (MEM) with 10% fetal bovine serum and measurements of drug concentrations via High Performance Liquid Chromatography (HPLC)...
June 14, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29892489/influence-of-postnatal-hydroureter-in-determining-the-need-for-voiding-cystourethrogram-in-children-with-high-grade-hydronephrosis
#4
Amr Hodhod, John-Paul Capolicchio, Roman Jednak, Eid El-Sherif, Abd El-Alim El-Doray, Mohamed El-Sherbiny
Objective: To evaluate the utility of hydroureter (HU) to identify high-grade vesico-ureteric reflux (VUR) in patients with high-grade postnatal hydronephrosis (PH). Patients and methods: We retrospectively reviewed patients' charts that had antenatal hydronephrosis from 2008 to 2014. Patients were excluded if they presented with febrile urinary tract infection (fUTI), neurogenic bladder, posterior urethral valve, multi-cystic dysplastic kidney, and multiple congenital malformations...
June 2018: Arab Journal of Urology
https://www.readbyqxmd.com/read/29889758/industry-payments-to-obstetricians-and-gynecologists-under-the-sunshine-act
#5
Tyler M Muffly, Whitney L Giamberardino, Joseph Guido, Robbie Weterings, Brittney Bastow, Jeanelle Sheeder
OBJECTIVE: To evaluate financial relationships between obstetrician-gynecologists (ob-gyns) and industry, including the prevalence, magnitude, and the nature of payments. METHODS: We conducted a cross-sectional study in which we obtained a list of industry contributions to U.S. obstetricians and gynecologists through the Centers for Medicare and Medicaid Services Open Payments Database from August 1, 2013, to December 31, 2015. These data were cross-referenced with the entire cohort of practicing obstetricians and gynecologists, who were identified using the National Provider Identification database, because not all practicing ob-gyns received payments...
June 6, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29889668/minimally-invasive-gynecologic-surgery-in-the-pregnant-patient-considerations-techniques-and-postoperative-management-per-trimester
#6
Arthur M Dizon, Erin T Carey
PURPOSE OF REVIEW: Nonobstetric surgery is performed in 1 : 200 to 1 : 500 of pregnant women in the United States annually. Previously, many argued that laparoscopy was contraindicated during pregnancy because of concerns for uterine injury and fetal malperfusion. Because surgeons have gained more experience with laparoscopy, it has become the preferred treatment modality for many surgical diseases in the gravid patient. RECENT FINDINGS: Specific preoperative considerations, intraoperative techniques, and postoperative management per trimester will be reviewed to optimize patient and surgical outcomes...
June 9, 2018: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29886608/-prenatal-interventional-therapy-in-two-cases-with-critical-pulmonary-stenosis-or-pulmonary-atresia-with-intact-ventricular-septum
#7
C C Pang, W Pan, Z W Zhang, C B Zhou, Y F Li, X Zhang, F Z Han, Y X Sun, S Wang, J Zhuang
Objectives: Two cases who underwent fetal pulmonary valvuloplasty (FPV) for pulmonary atresia with intact ventricular septum (PA-IVS) or critical pulmonary stenosis with intact ventricular septum (CPS-IVS) successfully were reported. The aim of the report was to explore the criteria for case selection, the technical essentials of FPV, and the postpartum outcome of the fetus. Methods: One case with PA-IVS and the other with CPS-IVS were enrolled in September 2016 and February 2017 in Guangdong General Hospital, and both cases were diagnosed with severe right ventricular dysplasia and tricuspid regurgitation by fetal echocardiogram...
June 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29879071/long-term-outcomes-of-kidney-and-bladder-function-in-patients-with-a-posterior-urethral-valve
#8
Sung Jin Kim, Jaeyoon Jung, Chanwoo Lee, Sejun Park, Sang Hoon Song, Hye-Sung Won, Kun Suk Kim
We investigated long-term functional changes in the kidney and bladder of patients with posterior urethral valve (PUV) who underwent fetal intervention or postnatal surgery.We retrospectively reviewed the medical records of 28 consecutive patients treated for PUV at our institution. Detailed data on medical and surgical histories, particularly on pre- and postnatal treatment modality, including fetal vesicoamniotic shunt, endoscopic valve ablation, and vesicostomy, were collected and analyzed. Long-term renal function was evaluated based on serum levels of creatinine (sCr), estimated glomerular filtration rate (eGFR), and renal scans...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29878553/predicting-premature-preterm-rupture-of-the-membranes-after-fetal-surgery
#9
Michael A Belfort
Premature preterm rupture of the membranes (PPROM) complicates fetal surgery in 23% of open neural tube defect repairs.(Moldenhauer et al. Fetal Diagn Ther 2015) PPROM increases the risk of contractions and delivery as well as the risk of inflammation/infection for both mother and baby. Identification of those patients at risk for PPROM following fetal surgery would clearly be useful. This article is protected by copyright. All rights reserved.
June 7, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29878531/perinatal-outcomes-after-open-fetal-surgery-for-myelomeningocele-repair-a-retrospective-cohort-study
#10
Antonio Fernandes Moron, Mauricio Mendes Barbosa, Herbene José Figuinha Milani, Stephanno Gomes Sarmento, Eduardo Felix Martins Santana, Italo Capraro Suriano, Patrícia Alessandra Dastoli, Sergio Cavalheiro
OBJECTIVE: Describe outcomes of open fetal surgery for myelomeningocele (MMC) repair in two Brazilian hospitals and the impact of surgical experience on outcome. DESIGN: Retrospective cohort study. SETTING: Sao Paulo, Brazil. POPULATION: 237 pregnant women carrying a fetus with an open spinal defect. METHODS: Surgical details and maternal and fetal outcomes collected from all patients. MAIN OUTCOME MEASURES: Analysis of surgical and perinatal outcome parameters...
June 7, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29878486/in-utero-open-surgery-progress-or-stagnation-in-the-prenatal-management-of-spina-bifida
#11
Yves Ville
This paper by Moron et al (BJOG 2018) is the largest of several studies to date that have followed the publication of the MOM's trial (Adzick N Engl J Med 2011); the paper revives several important and debatable issues. It confirms the reproducibility of the seminal trial of in utero open fetal surgery for spina bifida (SB); and suggests improvement and decreasing surgery-related morbidity with time and experience. But does it go so far as justifying prenatal surgery (Harrison N Engl J Med 1982)? This article is protected by copyright...
June 7, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29859676/preoperative-cerebral-hemodynamics-from-birth-to-surgery-in-neonates-with-critical-congenital-heart-disease
#12
Jennifer M Lynch, Tiffany Ko, David R Busch, John J Newland, Madeline E Winters, Kobina Mensah-Brown, Timothy W Boorady, Rui Xiao, Susan C Nicolson, Lisa M Montenegro, J William Gaynor, Thomas L Spray, Arjun G Yodh, Maryam Y Naim, Daniel J Licht
BACKGROUND: Hypoxic-ischemic white matter brain injury commonly occurs in neonates with critical congenital heart disease. Recent work has shown that longer time to surgery is associated with increased risk for this injury. In this study we investigated changes in perinatal cerebral hemodynamics during the transition from fetal to neonatal circulation to ascertain mechanisms that might underlie this risk. METHODS: Neonates with either transposition of the great arteries (TGA) or hypoplastic left heart syndrome (HLHS) were recruited for preoperative noninvasive optical monitoring of cerebral oxygen saturation, cerebral oxygen extraction fraction, and cerebral blood flow using diffuse optical spectroscopy and diffuse correlation spectroscopy, 2 noninvasive optical techniques...
May 3, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29842812/management-of-chaos-by-intact-cord-resuscitation-case-report-and-literature-review
#13
Manisha Kumar, Amit Gupta, Vijay Kumar, Anu Handa, Mayura Balliyan, Jyoti Meena, Shubhasis Roychoudhary
BACKGROUND: Congenital high airway obstruction syndrome (CHAOS) is a near fatal condition, except when the ex-utero intrapartum treatment (EXIT) procedure is performed as rescue. After antenatal diagnosis of the condition counseling regarding prognosis and outcome needs to be provided Case: We describe here a case with CHAOS due to isolated fetal laryngeal atresia, presented at our center at 33-week gestation. After counseling regarding the uncertain outcome, consent for elective caesarean was not given...
May 29, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29799890/-antenatal-ultrasound-diagnosis-and-neonatal-results-of-the-congenital-cystic-adenomatoid-malformation-of-the-lung
#14
Margarita Gallardo A, Margarita Álvarez de la Rosa R, José F De Luis E, Lorena Mendoza R, Ana Isabel Padilla P, Juan Troyano L
INTRODUCTION: Congenital cystic adenomatoid malformation (CCAM) is a rare congenital lung di sease, and in the most of cases, prenatal diagnosis is feasible. There are discrepancies regarding pre natal management and postpartum treatment. OBJECTIVE: To analyze prenatally diagnosed CCAM in our hospitals, in order to evaluate ultrasound findings with fetal and postnatal evolution. PATIENTS AND METHOD: Retrospective study of all cases diagnosed prenatally by ultrasound between 2005 and 2016 in two reference hospitals...
April 2018: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/29796693/neonatal-outcomes-in-total-anomalous-pulmonary-venous-return-the-role-of-prenatal-diagnosis-and-pulmonary-venous-obstruction
#15
Shelly Domadia, S Ram Kumar, Jodie K Votava-Smith, Jay D Pruetz
The objective of this study is to evaluate neonatal outcomes of total anomalous pulmonary venous return (TAPVR) and identify fetal echocardiography findings associated with preoperative pulmonary venous obstruction (PPVO). This retrospective study evaluated TAPVR cases from 2005 to 2014 for preoperative and postoperative outcomes based on prenatal diagnosis, PPVO, and heterotaxy syndrome. Fetal pulmonary and vertical vein Dopplers were analyzed as predictors of PPVO. Of 137 TAPVR cases, 12% were prenatally diagnosed; 60% had PPVO, and 21% had heterotaxy...
May 23, 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29786973/amniotic-fluid-lactic-acid-and-matrix-metalloproteinase-8-levels-at-the-time-of-fetal-surgery-for-a-spine-defect-association-with-subsequent-premature-preterm-rupture-of-membranes
#16
Antonio F Moron, Aikaterini Athanasiou, Mauricio Barbosa, Herbene J Milani, Stephanno G Sarmento, Sergio Cavalheiro, Steven S Witkin
OBJECTIVE: In utero fetal surgery to correct incomplete closure of the spinal cord lessens the extent of permanent damage but is associated with preterm premature rupture of membranes (pPROM). We determined if compounds in amniotic fluid (AF) collected at the time of surgery predicted subsequent development of pPROM. DESIGN: Prospective study. SETTING: Hospitals in Sao Paulo, Brazil. POPULATION: Twenty four consecutive pregnant women at 24-26 weeks gestation seen between February and October 2017 with a singleton pregnancy underwent in utero surgery to correct an open spinal defect in their fetus...
May 22, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29785547/analysis-of-factors-affecting-outcomes-of-pregnancy-complicated-by-echinococcus-an-algorithm-for-approach-and-management
#17
Sebahattin Celik, Ozan Okyay, Erbil Karaman, Özlem Z Sert, Numan Cim, Tuba Y Okyay
PURPOSE: The management of hydatid disease (HD) co-occurring with pregnancy remains a challenge for physicians. We aimed to determine factors that were related to fetal and maternal outcomes in HD complicated pregnancies and then develop an approach/treatment algorithm. METHOD: All patients at the participating hospitals were first analyzed to determine whether they had HD. Only patients diagnosed with HD during the course of their pregnancy were included. Certain cyst-related factors (diameter, localization, increase in size, and viability) and certain pregnancy-related factors (treatments, gestational week, maternal co-morbidities, and delivery type) were investigated...
May 21, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29782826/sheets-of-human-retinal-progenitor-transplants-improve-vision-in-rats-with-severe-retinal-degeneration
#18
Bin Lin, Bryce T McLelland, Anuradha Mathur, Robert B Aramant, Magdalene J Seiler
Loss of photoreceptors and other retinal cells is a common endpoint in retinal degenerate (RD) diseases that cause blindness. Retinal transplantation is a potential therapy to replace damaged retinal cells and improve vision. In this study, we examined the development of human fetal retinal sheets with or without their retinal pigment epithelium (RPE) transplanted to immunodeficient retinal degenerate rho S334ter-3 rats. Sheets were dissected from fetal human eyes (11-15.7 weeks gestation) and then transplanted to the subretinal space of 24-31 d old RD nude rats...
May 18, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29777883/atypical-presentation-of-giant-aneurysm-in-a-pediatric-patient-with-duane-syndrome
#19
Chao-Hung Kuo, Lynn B McGrath, Joseph A Carnevale, Neena I Marupudi, Jeffery G Ojemann, Richard G Ellenbogen, Anthony C Wang
BACKGROUND: Duane syndrome is a congenital eye movement disorder characterized by congenital malformation of the abducens nucleus. Thrombogenic conditions during development may lead to vascular anomalies in Duane syndrome, however, the presence of a giant aneurysm in this patient population is a rarely documented phenomenon. CASE DESCRIPTION: We reported a case of a large cerebral aneurysm in a pediatric patient with Duane syndrome, and performed a review of the literatures to identify other potential cases and associations...
May 16, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29772054/oxycodone-pharmacokinetics-and-fetal-exposure-after-intravenous-or-epidural-administration-to-the-ewe
#20
Mari Kinnunen, Hannu Kokki, Heidi Hautajärvi, Heikki Huhta, Veli-Pekka Ranta, Juha Räsänen, Hanna-Marja Voipio, Merja Kokki
INTRODUCTION: There are limited data of oxycodone pharmacokinetics during pregnancy and on fetal exposure after maternal administration. The present study describes the pharmacokinetics of intravenous oxycodone in pregnant sheep and fetal exposure after intravenous and epidural administration. MATERIAL AND METHODS: 10 pregnant sheep received 0.1 mg·kg-1 oxycodone intravenously -bolus, and blood samples were collected up to 24 hours. Seven days later, the ewes were randomized to receive 0...
May 17, 2018: Acta Obstetricia et Gynecologica Scandinavica
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