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https://www.readbyqxmd.com/read/29466789/two-port-fetoscopic-repair-of-myelomeningocele-in-fetal-lambs
#1
Lucie Guilbaud, Charles Garabedian, Nathalie Roux, Stéphanie Friszer, Ferdinand Dhombres, Raphaël Vialle, Zoobia Shah, Bettina Bessières, Federico Di Rocco, Michel Zerah, Jean-Marie Jouannic
OBJECTIVE: The aim of this study was to assess the feasibility and the effectiveness of a fetoscopic myelomeningocele (MMC) repair with a running single suture using a 2-port access in the sheep model. METHODS: Eighteen fetuses underwent surgical creation of a MMC defect at day 75. Fetuses were then randomized into 3 groups. Four fetuses remained untreated (control group). In the other 14 fetuses, a prenatal repair was performed at day 90: 7 fetuses had an open repair (oMMC), and 7 fetuses had a fetoscopic repair (fMMC) using a single-layer running suture through a 2-port access...
February 21, 2018: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/29460323/clinical-guidelines-for-prevention-and-management-of-preterm-birth-a-systematic-review
#2
Nancy Medley, Borna Poljak, Silvia Mammarella, Zarko Alfirevic
BACKGROUND: Clinical practice guidelines (CPG) endorse multiple strategies to prevent or manage preterm birth (PTB). OBJECTIVES: To summarise CPG recommendations for PTB and identify areas of international consensus. SEARCH STRATEGY: In June 2017 we searched for all CPG relavant to PTB without language restrictions. SELECTION CRITERIA: CPG were eligible if the following criteria were met. i.The guideline was published or current from June 2013...
February 20, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29457204/prevention-and-management-of-childhood-obesity
#3
Aashima Dabas, Anju Seth
Childhood obesity has been recognized as a global pandemic. Preventive strategies have proven to be the most effective public health intervention in curbing this pandemic. A multi-component approach involving dietary modification and advocacy for a healthy lifestyle comprising of regular physical activity, minimizing screen time and behavioral interventions have been found beneficial in preventing obesity. A life-cycle approach has been recommended where preventive interventions go as far back as affecting maternal, fetal and early childhood nutrition and lifestyle...
February 19, 2018: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29456901/awake-craniotomy-for-the-treatment-of-a-cortical-pseudoaneurysm-in-a-pregnant-patient
#4
Hirad Hedayat, Daniel R Felbaum, John E Reynolds, Rashid M Janjua
Neurosurgical pathologies presenting during pregnancy are uncommon. If present, the situation creates a unique diagnostic, observational, and therapeutic challenge as both lives are placed at potential risk. Surgical procedures during pregnancy are approached carefully as physiological stressors associated with surgery and anesthesia may cause fetal or maternal compromise. We present the only known case of a pseudoaneurysm treated with an awake craniotomy, allowing us to abate the risks associated with general anesthesia in pregnancy...
December 7, 2017: Curēus
https://www.readbyqxmd.com/read/29455793/maternal-and-fetal-outcome-in-operated-vs-non-operated-cases-of-congenital-heart-disease-cases-in-pregnancy
#5
Vikas Yadav, J B Sharma, S Mishra, A Kriplani, Neerja Bhatla, Garima Kachhawa, Rajesh Kumari, Karthik, Isha Kriplani
OBJECTIVES: To study pregnancy outcomes in operated vs non-operated cases of congenital heart disease cases during pregnancy. MATERIALS AND METHODS: A total of 55 patients of congenital heart disease who delivered in the authors unit in last 10 years were taken in this retrospective study. These were divided into two groups Group 1:29 (52.7%) patient who had no cardiac surgery and Group 2: 26(47.2%) who had cardiac surgery to correct their cardiac defect before pregnancy...
January 2018: Indian Heart Journal
https://www.readbyqxmd.com/read/29454127/neurosurgery-on-a-pregnant-woman-with-post-mortem-fetal-extrusion-an-unusual-case-from-medieval-italy
#6
REVIEW
Alba Pasini, Vanessa Samantha Manzon, Xabier Gonzalez-Muro, Emanuela Gualdi-Russo
Trepanation is one of the most ancient and applied surgical treatments; several archaeologically documented cases are known, dated back from Prehistory to the Middle ages. This case study reports the anthropological analysis of the skeletal remains of a young medieval woman and a fetus (Imola, Italy). The fetal remains were laid between her pelvis and lower limbs. A perforating injury was observed to her frontal bone. After assessing biological profiles, we attempted to interpret the injury and to reconstruct possible circumstances of death...
February 14, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29438655/short-term-neurodevelopmental-outcome-in-children-born-with-high-risk-congenital-lung-lesions
#7
Enrico Danzer, Casey Hoffman, Jo Ann D'Agostino, Matthew M Boelig, Marsha Gerdes, Judy C Bernbaum, Hannah Rosenthal, Lindsay N Waqar, Natalie E Rintoul, Lisa M Herkert, Michael J Kallan, William H Peranteau, Alan W Flake, N Scott Adzick, Holly L Hedrick
BACKGROUND: To evaluate neurodevelopmental outcome in high-risk congenital lung lesions (CLLs) survivors who underwent prenatal intervention or postnatal surgery within the first month of life. METHODS: Forty-five high-risk CLLs survivors underwent assessment using the Bayley Scales of Infant Development, 3rd Edition between 07/2004 and 12/2016. Scores were grouped as average, at-risk, and delayed based on standard deviation intervals. Correlations between outcome and risk factors were analyzed by Fisher's exact test or two-sided t-test as appropriate, with significant p-values <0...
February 10, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29432238/nervous-system-malformations
#8
John Gaitanis, Tomo Tarui
PURPOSE OF REVIEW: This article provides an overview of the most common nervous system malformations and serves as a reference for the latest advances in diagnosis and treatment. RECENT FINDINGS: Major advances have occurred in recognizing the genetic basis of nervous system malformations. Environmental causes of nervous system malformations, such as perinatal infections including Zika virus, are also reviewed. Treatment for nervous system malformations begins prior to birth with prevention...
February 2018: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/29419329/understanding-gastroschisis-and-its-clinical-management-where-are-we
#9
Candace Haddock, Erik D Skarsgard
Gastroschisis is the commonest developmental defect of the anterior abdominal wall in both developed and developing countries. The past 30 years have seen transformational improvements in outcome due to advances in neonatal intensive care and enhanced integration between the disciplines of maternal fetal medicine, neonatology and pediatric surgery. A review of gastroschisis, which emphasizes its epidemiology, multidisciplinary care strategies and contemporary outcomes is timely. Areas covered: This review discusses the current state of knowledge related to prevalence and causation, and postulated embryopathologic mechanisms contributing to the development of gastroschisis...
February 8, 2018: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29417735/fetal-bovine-serum-can-reduce-toxicity-of-indocyanine-green-brilliant-blue-g-and-trypan-blue-in-arpe-19-cellular-model-that-suggests-new-surgical-staining-protocols-for-internal-limiting-membrane-peeling-procedure
#10
Yu-Yi Lin, Jorn-Hon Liu, Yin Chang
BACKGROUND: To investigate and compare the cytotoxicity of indocyanine green (ICG), brilliant blue G (BBG) and trypan blue (TB) using ARPE-19 cells that have been pre-treated/post- treated with balanced salt solution (BSS) or fetal bovine serum (FBS). METHODS: The cultured human retina pigment epithelium (RPE) ARPE-19 cells were pre-treated/post-treated with BSS or FBS (represent the autologous serum in clinic) in parallel with cells being soaked with various concentrations of ICG, BBG, and TB...
February 8, 2018: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/29409551/impact-of-prenatal-diagnosis-on-the-management-and-early-outcome-of-critical-duct-dependent-cardiac-lesions
#11
Varsha Thakur, Nathalie Dutil, Steven M Schwartz, Edgar Jaeggi
OBJECTIVE: The objective of this study was to compare the preoperative management and outcome of neonates with duct-dependent critical CHD with fetal versus postnatal diagnosis. METHODS: Patients referred with CHD to our centre from January 1, 2009 to December 31, 2010 were enrolled prospectively. Live births with a critical form of CHD, a gestational age ⩾36 weeks and a weight ⩾2 kg at birth, and the intention-to-treat were included in this sub-study. Excluded were neonates with lethal non-cardiac and/or genetic anomalies...
February 7, 2018: Cardiology in the Young
https://www.readbyqxmd.com/read/29397624/-retrospective-analysis-of-diagnosis-and-treatment-of-breast-cancer-in-pregnancy
#12
F W Wang, S M Fu, Y C Jin, X H Gong, H D Cheng, K J Wu
Objective: To investigate the principles of diagnosis and treatment of breast cancer during pregnancy. Methods: Clinical data of patients with breast cancer during pregnancy admitted to Obstetrics and Gynecology Hospital of Fudan University between January 2012 to July 2017 were analyzed retrospectively. A total of 17 patients were diagnosed with breast cancer in pregnancy, the median age was 32 years (range from 25 to 45 years old), pathological staging revealed 2 patient with stage 0, 1 with stage Ⅱa, 7 with stage Ⅱb, 1 with stage Ⅲa, 2 with stage Ⅲc, 4 with stage Ⅳ...
February 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29391197/ocular-injury-during-fetal-endoscopy-surgery
#13
Mariana Flores-Pimentel, Alejandra G de Alba Campomanes
A premature infant born at 31 weeks' gestational age was evaluated for periocular laceration and retrobulbar hematoma secondary to injury during a percutaneous fetal procedure. He later developed optic nerve atrophy.
January 29, 2018: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/29391034/vena-cava-anomalies-in-thoracic-surgery
#14
Andreina Pagini, Massimiliano Bassi, Daniele Diso, Michele Anzidei, Sara Mantovani, Camilla Poggi, Federico Venuta, Marco Anile
BACKGROUND: Vena cava anomalies are a rare group of anatomical variations due to an incorrect development of the superior or inferior vena cava during fetal life. They generally show no clinical relevance and the diagnosis is done due to the association with congenital heart diseases in most of cases. However, preoperative identification of these anomalies is mandatory for surgeons to proper surgical planning. If not recognized, lethal complications may occur, as already reported in literature...
February 1, 2018: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29390544/anesthetic-management-of-primary-hyperparathyroidism-during-pregnancy-a-case-report
#15
Hong Zeng, Zhengqian Li, Xiaoqing Zhang, Ning Wang, Yang Tian, Jun Wang
RATIONALE: Primary hyperparathyroidism (PHPT) during pregnancy is rare. Nevertheless, hypercalcemia secondary to gestational PHPT may be masked by physiological changes in calcium homeostasis during pregnancy. Gestational PHPT constitutes a serious danger to mother and fetus. Surgery is the only curative treatment when conservative treatment could not control the condition. Due to the lack of guidelines concerning PHPT during pregnancy, the optimal anesthetic management of PHPT during pregnancy needs to be individualized...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29388237/safety-and-efficacy-of-fetal-surgery-techniques-to-close-a-spina-bifida-defect-in-the-fetal-lamb-model-a-systematic-review
#16
REVIEW
Luc Joyeux, Felix De Bie, Enrico Danzer, Tim Van Mieghem, Alan W Flake, Jan Deprest
OBJECTIVE: To determine the safety and efficacy of different neurosurgical techniques for closure of spina bifida (SB) in the fetal lamb model. METHOD: Systematic review of studies reporting on fetal lambs undergoing induction and closure of SB compared to non-operated normal lambs (negative controls) and/or lambs not undergoing closure of the defect (positive controls). Primary outcomes were (1) survival at birth (safety) and/or (2) presence of Somatosensory Evoked Potentials on hind limbs and/or improvement in quantitative histological spinal cord findings and/or reversal of hindbrain herniation (efficacy)...
January 31, 2018: Prenatal Diagnosis
https://www.readbyqxmd.com/read/29387735/mri-findings-of-complications-related-to-previous-uterine-scars
#17
REVIEW
Leonor Alamo, Yvan Vial, Alban Denys, Gustav Andreisek, Jean-Yves Meuwly, Sabine Schmidt
Although the World Health Organization suggests 10-15% as the adequate cesarean delivery rate to assure optimal prognosis for mother and children, cesarean rates have continuously increased worldwide over the last three decades, even in primiparous women. Moreover, uterine scars after myomectomies, complications of obstetrical interventions and more recently, after fetal surgery, are often observed. This review article describes the most commonly seen complications related to prior uterine scars and discusses their imaging findings, with emphasis on the increasing role of Magnetic Resonance Imaging for diagnosis...
2018: European Journal of Radiology Open
https://www.readbyqxmd.com/read/29372164/prenatal-diagnosis-of-isolated-coronary-arteriovenous-fistula
#18
Uisoo Chae, Mi-Young Lee, Hyerim Kim, Hye-Sung Won, Ki-Soo Kim, Hyun-Woo Goo, Jae-Kon Ko, Jeong-Jun Park
Coronary arteriovenous fistula (CAVF) is a rare condition defined as an anomalous termination of the coronary arteries. The etiology of CAVF is either congenital or acquired, and iatrogenic CAVF is most commonly caused by cardiovascular surgery or percutaneous intervention. Most of the prenatally diagnosed CAVFs were related to complex heart disease, and only few cases of an isolated CAVF have been reported to date. We successfully diagnosed an isolated CAVF by fetal echocardiography at 25.3 weeks of gestation...
January 2018: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/29369821/non-invasive-acquisition-of-fetal-ecg-from-the-maternal-xyphoid-process-a-feasibility-study-in-pregnant-sheep-and-a-call-for-open-data-sets
#19
Chao Shen, Martin G Frasch, Hau-Tieng Wu, Christophe Louis Herry, Mingju Cao, André Desrochers, Gilles Fecteau, Patrick Burns
OBJECTIVE: The utility of fetal heart rate (FHR) monitoring can only be achieved with an acquisition sampling rate that preserves the underlying physiological information on the millisecond time scale (1000 Hz rather than 4 Hz). For such acquisition, fetal ECG (fECG) is required, rather than the ultrasound to derive FHR. We tested one recently developed algorithm, SAVER, and two widely applied algorithms to extract fECG from a single channel maternal ECG signal recorded over the xyphoid process rather than the routine abdominal signal...
January 25, 2018: Physiological Measurement
https://www.readbyqxmd.com/read/29353282/differential-changes-in-myocardial-performance-index-and-its-time-intervals-in-donors-and-recipients-of-twin-to-twin-transfusion-syndrome-before-and-after-laser-therapy
#20
Javier U Ortiz, Ximena Torres, Elisenda Eixarch, Mar Bennasar, Monica Cruz-Lemini, Olga Gómez, Silvia M Lobmaier, Josep M Martínez, Eduard Gratacós, Fatima Crispi
OBJECTIVE: To evaluate left myocardial performance index (MPI) and time intervals in fetuses with twin-to-twin transfusion syndrome (TTTS) before and after laser surgery. METHODS: Fifty-one fetal pairs with TTTS and 47 uncomplicated monochorionic twin pairs were included. Left ventricular isovolumetric contraction time (ICT), ejection time (ET), and isovolumetric relaxation time (IRT) were measured using conventional Doppler. RESULTS: Recipients showed prolonged ICT (46 ± 12 vs...
January 19, 2018: Fetal Diagnosis and Therapy
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