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https://www.readbyqxmd.com/read/29444286/techniques-to-ensure-accurate-targeting-for-delivery-of-awake-laser-interstitial-thermotherapy
#1
Dimitri Laurent, Seth F Oliveria, Michael Shang, Frank Bova, Rachel Freedman, Maryam Rahman
BACKGROUND: Magnetic resonance imaging (MRI) guided laser interstitial thermal therapy (LITT) is an emerging neurosurgical treatment modality that is typically performed under general anesthesia. We describe a novel workflow developed at the University of Florida to deliver LITT in conscious patients without the use of general anesthesia. OBJECTIVE: To describe a novel workflow for LITT implementation in the awake patient with equivalent treatment results when compared to procedures performed under general anesthesia...
February 10, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29391134/lipemic-interference-of-ceruloplasmin-assays-an-evaluation-of-lipid-removal-methods
#2
Joshua J H Hunsaker, Sonia L La'ulu, Sara P Wyness, Jonathan R Genzen
BACKGROUND: The present studies were conducted to characterize lipemic interference across three FDA-cleared ceruloplasmin (CERU) assays and to evaluate procedures designed to remove lipemic interference. METHODS: CERU assays on the Abbott ARCHITECT ci8200, Beckman AU5800, and Roche cobas Integra 400 Plus were evaluated. Precision, linearity with dilution, lipemic interference, and three methods for removing lipemia were assessed on each platform: ultracentrifugation (UC), lipemia-clearing reagent LipoClear (LC), and 1:5 dilution (DIL)...
January 29, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29390202/-clinical-trial-regeneration-of-skin-perception-after-deep-degree-burns-in-childhood
#3
Stephan Fuchs, Gunter Klohs, Malte Kornhuber, Rainer Finke
BACKGROUND:  Cutaneous aesthesia is frequently impaired following thermal injury. The perception of pressure and touch is compromised. METHODS:  We analysed 352 patient files retrospectively and tested the perception in deep burn-damaged skin of children. The skin regions examined were classified into groups according to treatment: group 1: necrosectomy + split-thickness skin graft; group 2: epifascial necrosectomy + split-thickness skin graft; group 3: epifascial necrosectomy + Integra® + split- thickness skin graft...
February 1, 2018: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
https://www.readbyqxmd.com/read/29383271/survivorship-of-revision-wrist-replacement
#4
E M Pinder, K G Chee, M Hayton, S R Murali, S C Talwalkar, I A Trail
Purpose  This study aims to report the 5-year survivorship of revision wrist arthroplasties and to report midterm clinical and radiological results. Materials and Methods  All patients receiving a revision wrist arthroplasty in our unit between January 1, 1997 and October 31, 2010 were identified, and clinical notes retrospectively analyzed for Quick Disabilities of the Arm, Shoulder and Hand (quickDASH), Patient Evaluation Method (PEM), Patient-Rated Wrist Evaluation (PRWE), the range of movement, and visual analog score (VAS)...
February 2018: Journal of Wrist Surgery
https://www.readbyqxmd.com/read/29346567/epithelial-grafting-of-a-decellularized-whole-tracheal-segment-an-in-vivo-experimental-model
#5
Margot Den Hondt, Bart M Vanaudenaerde, Eric K Verbeken, Jan J Vranckx
OBJECTIVES: Prerequisites for successful trachea transplantation include the use of a biocompatible construct, submucosal vascularization and an epithelial covering. Implantation of non-epithelialized tracheal scaffolds may lead to stenosis. However, epithelial grafting or seeding can only be attempted onto a well-vascularized submucosal bed. Our aim was to investigate a method to prevent stenosis during prelamination of non-epithelialized, gently decellularized rabbit tracheae and to evaluate whether grafting of revascularized constructs with buccal mucosa is feasible...
January 15, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29333930/a-histological-analysis-of-artificial-skin-in-an-extensively-burned-child-14-years-after-application-a-case-report
#6
Robert Zajicek, Eva Sticova, Radana Königova
INTRODUCTION: Artificial skin has become the treatment of choice in extensive, full-thickness thermal injuries. The longest follow-up of the healing process in burn sites covered with the Integra Bilayer Matrix Wound Dressing onto the wound published to date was at around five years after application. In our case report, we describe the clinical and histological analysis of an extensive, full-thickness thermal injury 14 years on from treatment with the bilayer matrix wound dressing. CASE STUDY: A nine-year-old boy suffered a full-thickness skin loss over 85% of his body surface area following a fire accident...
January 2, 2018: Journal of Wound Care
https://www.readbyqxmd.com/read/29281065/usefulness-of-sealants-for-dural-closure-evaluation-in-an-in-vitro-model
#7
Tristan van Doormaal, Ahmet Kinaci, Sander van Thoor, Saskia Redegeld, Wilhelmina Bergmann, Albert van der Zwan
BACKGROUND: Cerebrospinal fluid (CSF) leakage occurs in 4% to 32% of cranial surgeries and is associated with significant patient burden and expense. The use of sealant as an adjunct to primary dural closure is assumed to help prevent CSF leakage. OBJECTIVE: To examine the utility of different sealants for dural closure using an in Vitro model. METHODS: We evaluated 9 commonly used dural sealants, including Tachosil (Takeda Inc, Osaka, Japan), Adherus (Hyperbranch Inc, Durham, North Carolina), Duraform (Codman, Raynham, Massachusetts), Tissudura (Baxter, Deerfield, Illinois), Hemopatch (Baxter), TissuePatchDural (Tissuemed, Leeds, United Kingdom), Tisseel (Baxter), Duragen Secure (Integra, Plainsboro, New Jersey), and Duraseal, (Integra)...
December 21, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29274159/effect-of-implant-placement-depth-on-the-peri-implant-bone-defect-configurations-in-ligature-induced-peri-implantitis-an-experimental-study-in-dogs
#8
B Huang, L Zhang, L Xu, W Zhu, L Witek, N Tovar, P-G Coelho, H Meng
BACKGROUND: The subcrestal placement of implant platform has been considered a key factor in the preservation of crestal bone, but the influence of implant placement depth on bone remodeling combined with peri-implantitis is not fully understood. The aim of this study was to assess the effect of the crestal or subcrestal placement of implants on peri-implant bone defects of ligature-induced peri-implantitis in dogs. MATERIAL AND METHODS: Eight weeks after tooth extraction in six beagle dogs, two different types of implants (A: OsseoSpeed(TM), Astra, Molndal, Sweden; B: Integra-CP(TM), Bicon, Boston, USA) were placed at either crestal or subcrestal (-1...
January 1, 2018: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/29248423/use-of-integra-in-oral-reconstruction-a-case-series
#9
L Rúa Gonzálvez, L de Villalaín Álvarez, A Novoa Gómez, J C de Vicente Rodríguez, I Peña González
OBJECTIVE: Small intraoral defects are usually reconstructed using skin autografts. However, the goal of this research was to describe an alternative to classic techniques using artificial dermis (Integra) in the reconstruction of these types of injuries. MATERIALS AND METHODS: Four patients with small intraoral lesions in different locations underwent resection. The created defects were covered with a bilayer of Integra; then, a chlorhexidine stent cure (Laboratorios Salvat, Barcelona, Spain) was applied...
November 15, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/29240590/reverse-sural-adipofascial-flaps-with-acellular-dermal-matrix-and-negative-pressure-wound-therapy
#10
Matthew E Pontell, Noah Saad, Brian S Winters, Joseph N Daniel, Adam Saad
The reverse sural adipofascial flap (RSAF) is used to reconstruct challenging wounds of the foot and ankle. It offers several advantages over the traditional reverse sural flap, including less venous congestion. To complete the reconstruction, split-thickness skin grafting (STSG) may be done immediately or in a delayed fashion; however, both scenarios result in suboptimal take rates and prolonged healing. An acellular dermal matrix (ADM; Integra; Ethicon Inc, Somerville, New Jersey) and negative-pressure wound therapy (NPWT) combined with RSAF followed by delayed STSG may decrease wound healing time...
January 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29226217/lipid-profile-in-tuberculosis-patients-with-and-without-human-immunodeficiency-virus-infection
#11
Gebremedhin Gebremicael, Yemane Amare, Feyissa Challa, Atsbeha Gebreegziabxier, Girmay Medhin, Mistire Wolde, Desta Kassa
Background: Understanding whether the preceding low lipid profile leads to active tuberculosis (TB) or active TB leads to low lipid profile is crucial. Methods: Lipid profile concentrations were determined from 159 study participants composed of 93 active TB patients [44 HIV coinfected (HIV+TB+) and 49 HIV negative (HIV-TB+)], 41 tuberculin skin test (TST) positive cases [17 HIV coinfected (HIV+TST+) and 24 HIV negative (HIV-TST+)], and 25 healthy controls (HIV-TST-)...
2017: International Journal of Chronic Diseases
https://www.readbyqxmd.com/read/29209583/what-makes-the-optimal-wound-healing-material-a-review-of-current-science-and-introduction-of-a-synthetic-nanofabricated-wound-care-scaffold
#12
REVIEW
Matthew R MacEwan, Sarah MacEwan, Tamas R Kovacs, Joel Batts
Wound matrix materials are used to improve the regeneration of dermal and epidermal layers in both acute and chronic wounds. Contemporary wound matrices are primarily composed of biologic materials such as processed xenogeneic and allogeneic tissues. Unfortunately, existing biologic wound matrices possess multiple limitations including poor longevity, durability, strength, and enzymatic resistance required for persistent support for new tissue formation. A fully-synthetic, resorbable electrospun material (Restrata Wound Matrix, Acera, St...
October 2, 2017: Curēus
https://www.readbyqxmd.com/read/29207693/serum-uric-acid-in-chronic-obstructive-pulmonary-disease-a-hospital-based-case-control-study
#13
Rajlaxmi Sarangi, Nirupama Varadhan, Jyotirmayee Bahinipati, Asha Dhinakaran, Anandaraj, Kandasamy Ravichandran
Introduction: Airway inflammation and imbalance between oxidant/anti-oxidant mechanisms are postulated to play a major role in the pathogenesis and exacerbation of Chronic Obstructive Pulmonary Disease (COPD). Previous studies on the role of serum Uric Acid (UA) in COPD subjects have been both confounding and inconclusive. Aim: To measure the serum UA levels among COPD subjects and to correlate with different stages of the disease. Materials and Methods: The study included 39 stable COPD subjects (21 males, 18 females; 13 smokers, 26 nonsmokers; age group; 40 to 60 years) and compared with 46 control subjects from the general population...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29205164/genital-reconstruction-with-integra%C3%A2-artificial-dermis-after-radical-resection-in-a-boy-with-diffuse-lymphangiomatosis
#14
Ana Rosa Tardáguila Calvo, José María Angulo Madero, Alberto Parente, Rosa María Romero, Susana Rivas
OBJECTIVE: Lymphangiomatosis is a rare disease affecting lymphatic vessels that causes a marked increase of them in the affected area. The final objective of treatment of the genital disease is to preserve sexual function and voiding with a satisfactory aesthetic result with the aim to minimize the emotional impact. METHODS: For the first time in children, we report a case of local reconstruction using artificial dermis after the excision of a genital lymphatic malformation in an eight year old patient...
December 2017: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/29194545/impact-of-integration-of-sexual-and-reproductive-health-services-on-consultation-duration-times-results-from-the-integra-initiative
#15
Mariana Siapka, Carol Dayo Obure, Susannah H Mayhew, Sedona Sweeney, Justin Fenty, Anna Vassall
The lack of human resources is a key challenge in scaling up of HIV services in Africa's health care system. Integrating HIV services could potentially increase their effectiveness and optimize the use of limited resources and clinical staff time. We examined the impact of integration of provider initiated HIV counselling and testing (PITC) and family planning (FP counselling and FP provision) services on duration of consultation to assess the impact of PITC and FP integration on staff workload. This study was conducted in 24 health facilities in Kenya under the Integra Initiative, a non-randomized, pre/post intervention trial to evaluate the impact of integrated HIV and sexual and reproductive health services on health and service outcomes...
November 1, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/29194544/numbers-systems-people-how-interactions-influence-integration-insights-from-case-studies-of-hiv-and-reproductive-health-services-delivery-in-kenya
#16
Susannah H Mayhew, Sedona Sweeney, Charlotte E Warren, Martine Collumbien, Charity Ndwiga, Richard Mutemwa, Irina Lut, Manuela Colombini, Anna Vassall
Drawing on rich data from the Integra evaluation of integrated HIV and reproductive-health services, we explored the interaction of systems hardware and software factors to explain why some facilities were able to implement and sustain integrated service delivery while others were not. This article draws on detailed mixed-methods data for four case-study facilities offering reproductive-health and HIV services between 2009 and 2013 in Kenya: (i) time-series client flow, tracking service uptake for 8841 clients; (ii) structured questionnaires with 24 providers; (iii) in-depth interviews with 17 providers; (iv) workload and facility data using a periodic activity review and cost-instruments; and (v) contextual data on external activities related to integration in study sites...
November 1, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/29131393/flap-monitoring-with-continuous-oxygen-partial-tension-measurement-in-breast-reconstructive-surgery-a-preliminary-report
#17
Emilio Trignano, Nefer Fallico, Luca Fiorot, Alberto Bolletta, Matteo Maffei, Pedro Ciudad, Michele Maruccia, Hung-Chi Chen, Gian Vittorio Campus
BACKGROUND: The best method for the postoperative monitoring of flaps in reconstructive surgery is still a matter of debate. The aim of this study is to evaluate the usefulness of an oxygen partial tension monitoring system for the postoperative follow-up of a series of breast flaps, in addition to the traditional periodical clinical evaluations. PATIENTS AND METHODS: Twenty-one consecutive female patients (mean age: 61 years) who underwent free- or pedicled-flap reconstruction of the breast were included in the study...
November 13, 2017: Microsurgery
https://www.readbyqxmd.com/read/29131112/spurious-hyperchloremia-in-the-presence-of-elevated-plasma-salicylate-a-cohort-study
#18
Kianoush B Kashani, Jon H Steuernagle Iv, Qi Qian
BACKGROUND: Acute metabolic acidosis is rarely associated with a reduced or negative anion gap (AG), but several case reports have described such an abnormality occurring in the setting of acute salicylate intoxication. The underlying cause of this phenomenon is unclear. METHODS: In this retrospective cohort study, we reviewed our institutional database to identify all patients admitted for salicylate intoxication at Mayo Clinic (Rochester, MN, USA) from January 2010 through December 2012...
November 9, 2017: Nephron
https://www.readbyqxmd.com/read/29098512/effect-of-planting-and-fertilization-on-lead-partitioning-in-dredged-sediment
#19
Tianxue Yang, Qiang He, Chunguang He, Aixia Wang, Lianxi Sheng
Dredging has been practiced to remove sediment impacted by persistent contaminants, such as heavy metals. Of these metals, lead (Pb) is of particular concern due to its toxicity. Therefore, dredged sediment containing Pb requires further mitigation. One method for Pb mitigation is phytoremediation of dredged sediment. In this study, the partitioning of Pb in sediment during phytoremediation by willow (Salix integra) was assessed. The results showed that, in general, the bioavailable forms of Pb declined with increased application of the standard Hoagland nutrient solution, which appeared to enhance the Fe-Mn oxide fraction and residual inert fraction...
November 2, 2017: Ecotoxicology
https://www.readbyqxmd.com/read/29047209/effects-of-cryopreservation-on-adipose-tissue-derived-microvascular-fragments
#20
Matthias W Laschke, Philipp Karschnia, Claudia Scheuer, Alexander Heß, Wolfgang Metzger, Michael D Menger
Adipose tissue-derived microvascular fragments (ad-MVF) are effective vascularization units for tissue engineering. They rapidly reassemble into new microvascular networks after seeding on scaffolds and subsequent in vivo implantation. Herein, we analyzed whether the vascularization capacity of ad-MVF is affected by cryopreservation. Ad-MVF were isolated from the epididymal fat pads of C57BL/6 mice and cryopreserved for 7 days to compare their morphology, viability, cellular composition and protein expression with freshly isolated control ad-MVF...
October 19, 2017: Journal of Tissue Engineering and Regenerative Medicine
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