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https://www.readbyqxmd.com/read/29209583/what-makes-the-optimal-wound-healing-material-a-review-of-current-science-and-introduction-of-a-synthetic-nanofabricated-wound-care-scaffold
#1
REVIEW
Matthew R MacEwan, Sarah MacEwan, Tamas R Kovacs, Joel Batts
Wound matrix materials are used to improve the regeneration of dermal and epidermal layers in both acute and chronic wounds. Contemporary wound matrices are primarily composed of biologic materials such as processed xenogeneic and allogeneic tissues. Unfortunately, existing biologic wound matrices possess multiple limitations including poor longevity, durability, strength, and enzymatic resistance required for persistent support for new tissue formation. A fully-synthetic, resorbable electrospun material (Restrata Wound Matrix, Acera, St...
October 2, 2017: Curēus
https://www.readbyqxmd.com/read/29207693/serum-uric-acid-in-chronic-obstructive-pulmonary-disease-a-hospital-based-case-control-study
#2
Rajlaxmi Sarangi, Nirupama Varadhan, Jyotirmayee Bahinipati, Asha Dhinakaran, Anandaraj, Kandasamy Ravichandran
Introduction: Airway inflammation and imbalance between oxidant/anti-oxidant mechanisms are postulated to play a major role in the pathogenesis and exacerbation of Chronic Obstructive Pulmonary Disease (COPD). Previous studies on the role of serum Uric Acid (UA) in COPD subjects have been both confounding and inconclusive. Aim: To measure the serum UA levels among COPD subjects and to correlate with different stages of the disease. Materials and Methods: The study included 39 stable COPD subjects (21 males, 18 females; 13 smokers, 26 nonsmokers; age group; 40 to 60 years) and compared with 46 control subjects from the general population...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29205164/genital-reconstruction-with-integra%C3%A2-artificial-dermis-after-radical-resection-in-a-boy-with-diffuse-lymphangiomatosis
#3
Ana Rosa Tardáguila Calvo, José María Angulo Madero, Alberto Parente, Rosa María Romero, Susana Rivas
OBJECTIVE: Lymphangiomatosis is a rare disease affecting lymphatic vessels that causes a marked increase of them in the affected area. The final objective of treatment of the genital disease is to preserve sexual function and voiding with a satisfactory aesthetic result with the aim to minimize the emotional impact. METHODS: For the first time in children, we report a case of local reconstruction using artificial dermis after the excision of a genital lymphatic malformation in an eight year old patient...
December 2017: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/29194545/impact-of-integration-of-sexual-and-reproductive-health-services-on-consultation-duration-times-results-from-the-integra-initiative
#4
Mariana Siapka, Carol Dayo Obure, Susannah H Mayhew, Sedona Sweeney, Justin Fenty, Anna Vassall
The lack of human resources is a key challenge in scaling up of HIV services in Africa's health care system. Integrating HIV services could potentially increase their effectiveness and optimize the use of limited resources and clinical staff time. We examined the impact of integration of provider initiated HIV counselling and testing (PITC) and family planning (FP counselling and FP provision) services on duration of consultation to assess the impact of PITC and FP integration on staff workload. This study was conducted in 24 health facilities in Kenya under the Integra Initiative, a non-randomized, pre/post intervention trial to evaluate the impact of integrated HIV and sexual and reproductive health services on health and service outcomes...
November 1, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/29194544/numbers-systems-people-how-interactions-influence-integration-insights-from-case-studies-of-hiv-and-reproductive-health-services-delivery-in-kenya
#5
Susannah H Mayhew, Sedona Sweeney, Charlotte E Warren, Martine Collumbien, Charity Ndwiga, Richard Mutemwa, Irina Lut, Manuela Colombini, Anna Vassall
Drawing on rich data from the Integra evaluation of integrated HIV and reproductive-health services, we explored the interaction of systems hardware and software factors to explain why some facilities were able to implement and sustain integrated service delivery while others were not. This article draws on detailed mixed-methods data for four case-study facilities offering reproductive-health and HIV services between 2009 and 2013 in Kenya: (i) time-series client flow, tracking service uptake for 8841 clients; (ii) structured questionnaires with 24 providers; (iii) in-depth interviews with 17 providers; (iv) workload and facility data using a periodic activity review and cost-instruments; and (v) contextual data on external activities related to integration in study sites...
November 1, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/29131393/flap-monitoring-with-continuous-oxygen-partial-tension-measurement-in-breast-reconstructive-surgery-a-preliminary-report
#6
Emilio Trignano, Nefer Fallico, Luca Fiorot, Alberto Bolletta, Matteo Maffei, Pedro Ciudad, Michele Maruccia, Hung-Chi Chen, Gian Vittorio Campus
BACKGROUND: The best method for the postoperative monitoring of flaps in reconstructive surgery is still a matter of debate. The aim of this study is to evaluate the usefulness of an oxygen partial tension monitoring system for the postoperative follow-up of a series of breast flaps, in addition to the traditional periodical clinical evaluations. PATIENTS AND METHODS: Twenty-one consecutive female patients (mean age: 61 years) who underwent free- or pedicled-flap reconstruction of the breast were included in the study...
November 13, 2017: Microsurgery
https://www.readbyqxmd.com/read/29131112/spurious-hyperchloremia-in-the-presence-of-elevated-plasma-salicylate-a-cohort-study
#7
Kianoush B Kashani, Jon H Steuernagle Iv, Qi Qian
BACKGROUND: Acute metabolic acidosis is rarely associated with a reduced or negative anion gap (AG), but several case reports have described such an abnormality occurring in the setting of acute salicylate intoxication. The underlying cause of this phenomenon is unclear. METHODS: In this retrospective cohort study, we reviewed our institutional database to identify all patients admitted for salicylate intoxication at Mayo Clinic (Rochester, MN, USA) from January 2010 through December 2012...
November 9, 2017: Nephron
https://www.readbyqxmd.com/read/29098512/effect-of-planting-and-fertilization-on-lead-partitioning-in-dredged-sediment
#8
Tianxue Yang, Qiang He, Chunguang He, Aixia Wang, Lianxi Sheng
Dredging has been practiced to remove sediment impacted by persistent contaminants, such as heavy metals. Of these metals, lead (Pb) is of particular concern due to its toxicity. Therefore, dredged sediment containing Pb requires further mitigation. One method for Pb mitigation is phytoremediation of dredged sediment. In this study, the partitioning of Pb in sediment during phytoremediation by willow (Salix integra) was assessed. The results showed that, in general, the bioavailable forms of Pb declined with increased application of the standard Hoagland nutrient solution, which appeared to enhance the Fe-Mn oxide fraction and residual inert fraction...
November 2, 2017: Ecotoxicology
https://www.readbyqxmd.com/read/29047209/effects-of-cryopreservation-on-adipose-tissue-derived-microvascular-fragments
#9
Matthias W Laschke, Philipp Karschnia, Claudia Scheuer, Alexander Heß, Wolfgang Metzger, Michael D Menger
Adipose tissue-derived microvascular fragments (ad-MVF) are effective vascularization units for tissue engineering. They rapidly reassemble into new microvascular networks after seeding on scaffolds and subsequent in vivo implantation. Herein, we analyzed whether the vascularization capacity of ad-MVF is affected by cryopreservation. Ad-MVF were isolated from the epididymal fat pads of C57BL/6 mice and cryopreserved for 7 days to compare their morphology, viability, cellular composition and protein expression with freshly isolated control ad-MVF...
October 19, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29041024/-scar-contracture-with-hyperextension-in-the-wrist-due-to-extravasation-in-the-childhood-two-stage-scar-correction-with-the-dermal-regeneration-template-integra%C3%A2-and-skin-graft
#10
Fabian R Wissing, Seung-Min Ryu, Henrik Menke
No abstract text is available yet for this article.
October 2017: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
https://www.readbyqxmd.com/read/28977224/relational-technologies-as-instruments-of-care-in-the-family-health-strategy
#11
Tatiana Fernandes Kerches de Abreu, Fernanda Amendola, Monica Martins Trovo
Objective: This article aims to identify the relational technologies used by Family Health Strategy nurses in their daily work when treating patients. Method: Descriptive and cross-sectional study with qualitative approach; conducted between May and July 2015, in three Basic Health Units of the Southern Region of the Municipality of São Paulo, with 19 nurses of the Family Health Strategy. Data were collected through a semi-structured interview, and the speeches were fully transcribed and analyzed according to the technique of content analysis...
September 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/28977223/knowledge-and-practice-in-mental-health-nursing-care
#12
Teresa Cristina da Silva Kurimoto, Claudia Maria de Mattos Penna, Débora Isane Ratner Kirschbaum Nitkin
Objective: To understand mental health nursing care based on the concept of the subject of the unconscious proposed by Lacan. Method: A narrative study was carried out with 19 nurses, chosen based on their theoretical approach or referral by other participants, through the snowball sampling technique. The interviews were carried out in person or digitally, and were recorded and fully transcribed. Results: The analysis was carried out based on Freudian and Lacanian psychoanalysis, approaching nursing care as it acts on the body, secretions, and excretions, to distinguish it from the spirit of fineness...
September 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/28894708/hepatic-proteins-and-inflammatory-markers-in-rheumatoid-arthritis-patients
#13
Manel Ben-Hadj-Mohamed, Souhir Khelil, Mokhles Ben Dbibis, Latifa Khlifi, Hend Chahed, Salima Ferchichi, Elyes Bouajina, Abdelhédi Miled
BACKGROUND: Rheumatoid arthritis is an autoimmune inflammatory rheumatic disease that causes chronic synovial inflammation eventually leading to joint destruction and disability. The aim of this study was to determine the variations of hepatic proteins, myeloperoxidase, and iron in rheumatoid arthritis Tunisian patients and their implications in inflammation and in iron metabolism. METHODS: Overall, 172 patients from the Rheumatology Department of the University Hospital "Farhat Hached", Sousse-Tunisia between 2011 and 2012, with rheumatoid arthritis (97...
August 2017: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/28891728/bioengineered-dermal-substitutes-for-the-management-of-traumatic-periocular-tissue-loss
#14
Tiffany A Chen, Juan A Ayala-Haedo, Nathan W Blessing, Katie Topping, Chrisfouad R Alabiad, Benjamin P Erickson
PURPOSE: Traumatic periocular injuries occasionally result in significant soft tissue loss, for which there are limited management options that provide satisfactory cosmetic and functional outcomes. The authors describe the use of a bioengineered dermal substitute (Integra® Dermal Regeneration Template [DRT], Integra LifeSciences, Plainsboro, NJ) as an alternative to immediate flap reconstruction or skin grafting. METHODS: Retrospective interventional case series of patients who underwent DRT placement for periocular tissue loss at the time of trauma...
September 11, 2017: Orbit
https://www.readbyqxmd.com/read/28888472/integra-%C3%A2-as-a-single-stage-dermal-regeneration-template-in-reconstruction-of-large-defects-of-the-scalp
#15
G Vithlani, P Santos Jorge, E Brizman, K Mitsimponas
Dermal regeneration templates may be used in the reconstruction of large defects after the excision of cutaneous malignancies. We describe the successful use of Integra(®) (Integra Lifesciences Corporation, Plainsboro, NJ, USA) as a single-stage regeneration template after the excision of multiple lesions of the scalp with a surface area of 96.7cm(2). Second-stage epidermal autografting was precluded because of an unforeseen deterioration in the patient's condition, and the wound re-epithelialised over a period of six months...
October 2017: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/28869383/experience-with-integra%C3%A2-at-the-prague-burns-centre-2002-2016
#16
R Zajíček, I Grossová, H Šuca, R Kubok, I Pafčuga
INTRODUCTION: Integra® dermal replacement has a wide spectrum of use both in burn medicine as well as in reconstructive plastic surgery and traumatology. Since 2002, it has been a part of surgical treatment of patients at Prague Burns Centre of the Královské Vinohrady Teaching Hospital. STUDY GROUP: Integra® was used in 47 patients in total between years 2002 and 2016. In this group there were 28 paediatric patients and 19 adult patients. Eleven children were operated during the reconstructive period, 8 children had an acute injury...
2017: Acta Chirurgiae Plasticae
https://www.readbyqxmd.com/read/28856213/analytical-verification-and-quality-assessment-of-the-tosoh-hlc-723gx-hba1c-analyzer
#17
Marko Ris, Sandra Božičević, Vanja Radišić Biljak, Marijana Vučić Lovrenčić
OBJECTIVES: Ion-exchange high-performance liquid chromatography (IE-HPLC) has long been used as a reproducible and versatile analytical tool for HbA1c measurement. In this study, we performed analytical verification and quality assessment of the recently introduced small IE-HPLC Tosoh HLC-723GX HbA1c analyzer, and a comparison of results to immunoassay (IA) and capillary electrophoresis (CE). DESIGN AND METHODS: The total imprecision of Tosoh HLC-723GX was verified according to CLSI EP15-A2 protocol using commercial control materials (C-QC) and pooled human whole blood samples (HWB)...
April 2017: Practical Laboratory Medicine
https://www.readbyqxmd.com/read/28812933/use-of-bilayer-matrix-wound-dressing-in-the-exenterated-socket
#18
Leon Rafailov, Roger E Turbin, Paul D Langer
To describe the novel use of a bilayer dermal substitute to reconstruct exenterated orbits. A retrospective chart review was performed in the practices of two surgeons (RET and PDL) of all patients who had undergone orbital exenteration between April 2014 and June 2016 and whose subsequent reconstruction included lining the socket with Integra bilayer. Patient demographics, pathologic diagnoses, surgical and post-operative complications, graft integrity, and patient acceptance were recorded. The charts of 7 patients (4 men and 3 women, ages 60-87 years) were reviewed...
August 16, 2017: Orbit
https://www.readbyqxmd.com/read/28810287/seeding-density-is-a-crucial-determinant-for-the-in-vivo-vascularisation-capacity-of-adipose-tissue-derived-microvascular-fragments
#19
T Später, C Körbel, F S Frueh, R M Nickels, M D Menger, M W Laschke
Adipose tissue-derived microvascular fragments (ad-MVF) represent effective vascularisation units for the seeding of dermal substitutes. However, particularly in case of extensive skin defects, the required amounts of donor fat tissue for the harvesting of ad-MVF may not always be available. Therefore, we herein determined the lowest ad-MVF density needed to induce a sufficient vascularisation and incorporation of seeded implants. Collagen-glycosaminoglycan matrices (Integra®; diameter: 4 mm) were seeded with 15,000 (HD), 10,000 (MD) and 5,000 (LD) ad-MVF and implanted into full-thickness skin defects within mouse dorsal skinfold chambers, to analyse their in vivo vascularisation and incorporation...
August 15, 2017: European Cells & Materials
https://www.readbyqxmd.com/read/28720057/use-of-integra-in-the-management-of-complex-hand-wounds-from-cancer-resection-and-nonburn-trauma
#20
Michael Reynolds, David A Kelly, Nicholas J Walker, Clayton Crantford, Anthony J Defranzo
BACKGROUND: Despite extensive use of Integra in burn reconstruction, little has been published regarding its utility in complex hand wounds from nonburn trauma or cancer resection. This study aimed to review outcomes following Integra use for hand reconstruction following cancer resection or nonburn trauma with exposed bone, joints, and/or tendons. METHODS: Retrospective review was performed of patients undergoing hand reconstruction with Integra for exposed bones, joints, or tendons over a 6-year period at a single institution...
February 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
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