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https://www.readbyqxmd.com/read/28301031/management-changes-resulting-from-hospital-accreditation
#1
João Lucas Campos de Oliveira, Carmen Silvia Gabriel, Hosanna Pattrig Fertonani, Laura Misue Matsuda
Objective: to analyze managers and professionals' perceptions on the changes in hospital management deriving from accreditation. Method: descriptive study with qualitative approach. The participants were five hospital quality managers and 91 other professionals from a wide range of professional categories, hierarchical levels and activity areas at four hospitals in the South of Brazil certified at different levels in the Brazilian accreditation system. They answered the question "Tell me about the management of this hospital before and after the Accreditation"...
March 2, 2017: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/28291502/skin-regeneration-using-dermal-substrates-that-contain-autologous-cells-and-silver-nanoparticles-to-promote-antibacterial-activity-in-vitro-studies
#2
Michael A J Zieger, Manuel Ochoa, Rahim Rahimi, Gonzalo Campana, Sunil Tholpady, Babak Ziaie, Rajiv Sood
We hypothesized that the addition of silver nanoparticles (AgNP) to a dermal substrate would impart antibacterial properties without inhibiting the proliferation of contained cells. Our in vitro model was based on the commercial substrate, Integra. The substrate was prepared by simple immersion into 0 to 1% suspension of AgNP (75 or 200 nm diameter) followed by rinsing for 20 minutes and sterilization under an ultraviolet C lamp. A total of 10(7) human adipose stem cells per cubic centimeter were injected and after 1 hour, 6 × 10(5) keratinocytes/cm(2) were seeded and cultured for up to 14 days...
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28203511/a-retrospective-look-at-integrating-a-novel-regenerative-medicine-approach-in-plastic-limb-reconstruction
#3
Edgardo R Rodriguez Collazo, Christopher R Rathbone, Brian R Barnes
Full-thickness wounds that have rendered patients candidates for amputation may require techniques that may include a combinatorial approach above traditional standard of care. The purpose of this retrospective study was to evaluate the effectiveness of an innovative approach whereby several therapies were combined to avoid amputation. Patients with full-thickness wounds who were previously recommended for amputation and were treated with the combinatorial approach of muscle flap reconstruction and concentrated bone marrow aspirate, platelet-rich plasma, INTEGRA Wound matrix, vacuum-assisted closure, and split-thickness skin grafts were assessed retrospectively...
January 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28196036/a-prospective-study-of-four-total-ankle-arthroplasty-implants-by-non-designer-investigators
#4
Tina Lefrancois, Alastair Younger, Kevin Wing, Murray J Penner, Peter Dryden, Hubert Wong, Timothy Daniels, Mark Glazebrook
BACKGROUND: There are several types of prostheses available to surgeons when performing a total ankle arthroplasty (TAA). The main objective of this study was to summarize the clinical and functional outcomes of 4 TAA prostheses: the Hintegra implant (Integra LifeSciences), the Agility implant (DePuy), the Mobility implant (DePuy), and the Scandinavian Total Ankle Replacement (STAR) implant (Small Bone Innovations [SBi]). METHODS: Patients were prospectively recruited...
February 15, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28164565/multicenter-evaluation-of-a-new-high-throughput-hba1c-testing-platform
#5
R Imdahl, R Roddiger, E Casis-Saenz
BACKGROUND: This non-interventional, multicenter study with anonymized leftover patient samples was performed to evaluate the reliability and analytical performance of the novel high-throughput HbA1c cobas c 513 analyzer. METHODS: A performance evaluation was carried out at three sites to validate the overall system functionality, user interaction and analytical performance of the new cobas c 513 analyzer using the Tina-quant® HbA1c Gen. 3 assay. RESULTS: HbA1c applications for both whole blood and hemolysate samples show a high precision using both quality control materials and pools of whole blood or hemolysates...
December 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28153583/evolution-of-skin-grafting-for-treatment-of-burns-reverdin-pinch-grafting-to-tanner-mesh-grafting-and-beyond
#6
REVIEW
Mansher Singh, Kristo Nuutila, K C Collins, Anne Huang
BACKGROUND: Skin grafting is the current standard care in the treatment of full thickness burns. It was first described around 1500 BC but the vast majority of advancements have been achieved over the past 200 years. METHODS: An extensive literature review was conducted on Pubmed, Medline and Google Scholar researching the evolution of skin grafting techniques. The authors concentrated on the major landmarks of skin grafting and also provide an overview of ongoing research efforts in this field...
January 30, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28129211/a-new-form-of-artificial-skin-to-promote-permanent-wound-coverage-a-preliminary-report
#7
Hsian-Jenn Wang, Lin-Gwei Wei, Chi-Hsien Wang, Ya-Chen Cheng, Junn-Liang Chang, Tai-Li Tsou, Chih-Hung Ku, Chun-Chang Li, Wen-Kuan Chiu, Chieh-Feng Chen
BACKGROUND: Although tendon-exposed or bone-exposed wounds can be resurfaced with flaps, such surgeries may not be feasible in patients with poor general or local conditions. Biosynthetic artificial skin is an alternative for critical wound coverage. We designed a new artificial skin bilayer to close difficult wounds permanently. AIM AND OBJECTIVES: This study compares incorporation and wound contraction between silicone acellular porcine dermis (SAPD) and the Integra graft (Integra Life Sciences Corp...
March 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28121720/the-use-of-integra%C3%A2-dermal-regeneration-template-for-the-orbital-exenteration-socket-a-novel-technique
#8
Cem Ozgonul, Ana Beatriz Diniz Grisolia, Hakan Demirci
PURPOSE: Integra® dermal regeneration template is a bilayer membrane system that acts as a scaffold for regenerating dermal skin cells. It is used for wound reconstruction following burns, extensive injuries, and a large tumor excision in multiple parts of the body. The dermal layer is made of porous matrix of bovine tendon collagen and glycosaminoglycan. The epidermal layer is made of polysiloxane layer. In this study, the authors evaluated the use of Integra® dermal regeneration template for the immediate reconstruction of the orbital exenteration socket...
January 23, 2017: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27903444/design-of-an-elastin-layered-dermal-regeneration-template
#9
Suzanne M Mithieux, Anthony S Weiss
We demonstrate a novel approach for the production of tunable quantities of elastic fibers. We also show that exogenous tropoelastin is rate-limiting for elastin synthesis regardless of the age of the dermal fibroblast donor. Additionally, we provide a strategy to further enhance synthesis by older cells through the application of conditioned media. We show that this approach delivers an elastin layer on one side of the leading dermal repair template for contact with the deep dermis in order to deliver prefabricated elastic fibers to a physiologically appropriate site during subsequent surgery...
November 27, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27866883/comparison-of-contraction-among-three-dermal-substitutes-morphological-differences-in-scaffolds
#10
Keijiro Hori, Atsuyoshi Osada, Tsukasa Isago, Hiroyuki Sakurai
Various kinds of synthetic dermal substitutes are produced and used in clinical application and contribute to wound bed preparation for subsequent skin grafting. Although their appearance and outcomes are different, the criteria for the selection of proper synthetic dermal substitutes is not well defined yet. In this study, we focused on the contraction of dermal substitutes and compared the morphological differences in scaffolds. A marked contraction was observed with Pelnac(®) compared to Integra(®) and Terudermis(®) in vitro...
November 17, 2016: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/27866363/comparative-of-quercus-spp-and-salix-spp-for-phytoremediation-of-pb-zn-mine-tailings
#11
Xiang Shi, Shufeng Wang, Haijing Sun, Yitai Chen, Dongxue Wang, Hongwei Pan, Yazhu Zou, Jianfeng Liu, Linyu Zheng, Xiulian Zhao, Zeping Jiang
A pot experiment was conducted to evaluate the feasibility of using tree seedlings for the phytoremediation of lead/zinc (Pb/Zn) mine tailings. Seedlings of three Quercus spp. (Q. shumardii, Q. phellos, and Q. virginiana) and rooted cuttings of two Salix spp. (S. matsudana and S. integra) were transplanted into pots containing 50 and 100 % Pb/Zn mine tailings to evaluate their tolerance of heavy metals. The five species showed different tolerance levels to the Pb/Zn tailings treatments. Q. virginiana was highly tolerant to heavy metals and grew normally in the Pb/Zn tailings...
February 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27862914/in-vivo-biocompatibility-vascularization-and-incorporation-of-integra-%C3%A2-dermal-regenerative-template-and-flowable-wound-matrix
#12
Thomas Später, Florian S Frueh, Wolfgang Metzger, Michael D Menger, Matthias W Laschke
Integra(®) matrix wound dressing (MWD) is used for the reconstruction of full-thickness skin defects. For the treatment of complex wounds, this dermal substitute is available as a flowable wound matrix (FWM) of identical composition. To clarify whether variations in sample preparation and consistency affect the biocompatibility and tissue incorporation, we herein compared MWD and FWM. The matrices were characterized using scanning electron microscopy and histology. Moreover, they were implanted in mouse dorsal skinfold chambers to analyze their in vivo performance over 2 weeks...
November 14, 2016: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/27836621/analytical-performance-of-three-whole-blood-point-of-care-lactate-devices-compared-to-plasma-lactate-comparison-methods-and-a-flow-injection-mass-spectrometry-method
#13
COMPARATIVE STUDY
Nicole V Tolan, Amy M Wockenfus, Christopher D Koch, Bridgit O Crews, Dennis J Dietzen, Brad S Karon
OBJECTIVES: Point of care (POC) whole blood lactate testing may facilitate rapid detection of sepsis. We evaluated three POC methods against both plasma lactate comparison methods and a flow-injection mass spectrometric (MS) method. DESIGN AND METHODS: Nova StatStrip, Abbott i-STAT CG4+ and Radiometer ABL90 POC lactate methods were evaluated against the mean of Cobas Integra 400 and Vitros 350 plasma lactate. POC methods were also compared to a flow-injection mass spectrometric assay measuring lactate in ZnSO4-precipitated whole blood extracts...
March 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/27826471/integra-based-reconstruction-of-large-scalp-wounds-a-case-report-and-systematic-review-of-the-literature
#14
Maxwell B Johnson, Alex K Wong
BACKGROUND: Large complex scalp wounds that have traditionally required free vascularized tissue transfer have been successfully reconstructed with skin substitutes such as Integra. Although there are multiple reports of Integra-based reconstructions of scalp wounds, there has not been a comprehensive assessment of this body of literature that critically examines this method. Our goal was to conduct a systematic review to determine the effectiveness of Integra-based reconstructions of scalp wounds, with emphasis on large defects...
October 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/27826090/subdural-empyema-in-the-setting-of-multimodal-intracranial-monitoring
#15
Jian Guan, Emily S Spivak, Christopher Wilkerson, Min S Park
BACKGROUND: Multimodal intracranial monitoring is becoming an increasingly common tool in the management of patients with traumatic brain injury. Although numerous reports detailing the benefits of such advanced monitoring exist in the literature, there is minimal discussion of the possible complications that may arise in this patient population. CASE DESCRIPTION: We report the case of a 32-year-old patient who had been assaulted and presented initially at an outside facility with a Glasgow Coma Scale score of 8...
January 2017: World Neurosurgery
https://www.readbyqxmd.com/read/27810611/management-of-skin-defect-following-resection-of-stage-iv-scalp-melanoma-a-case-report
#16
Yana Puckett, Eileen Bui, Sharmila Dissanaike
INTRODUCTION: Surgical defect left following excision of a large and neglected scalp melanoma of can pose a significant challenge for the surgeon. Scalp reconstruction encompasses options such as skin flaps, grafts, and various mechanical techniques. In scalp excision that involves dissection beyond the galea, skin grafts and flaps may not take well and not enough tissue may be available for a skin flap. PRESENTATION OF CASE: We present the case of a 64 year-old male with a giant scalp melanoma...
2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27779431/acellular-dermal-matrix-new-applications-for-free-flap-pedicle-coverage-a-prospective-study-in-10-patients
#17
Franck Leclère, Emilie Desnouveaux, H Chouri, Vincent Casoli
INTRODUCTION: The goal of lower extremity reconstruction after trauma is the coverage of defects to give patients a healed wound and to let them resume their life, ambulate, and return to work while preventing amputation. In this article we describe an innovative use of Integra® for free flap pedicle coverage in lower extremity reconstruction. MATERIALS AND METHODS: Between January 2011 and December 2015, ten patients, 4 women and 6 men, underwent a lower limb reconstruction with an association of free flap and integra® to cover the flap pedicle...
October 25, 2016: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/27771996/how-regenerative-medicine-stakeholders-adapt-to-ever-changing-technology-and-regulatory-challenges-snapshots-from-the-world-termis-industry-symposium-september-10-2015-boston
#18
Yves Bayon, Mark Van Dyke, Robert Buelher, Ross Tubo, Tim Bertram, Bernard Malfroy-Camine, Michelle Rathman, Vincent Ronfard
Regenerative medicine (RM) is a fascinating area of research and innovation. The huge potential of the field has been fairly underexploited so far. Both TERMIS-AM and TERMIS-EU Industry Committees are committed to mentoring and training young entrepreneurs for more successful commercial translation of upstream research. With this objective in mind, the two entities jointly organized an industry symposium during the past TERMIS World Congress (Boston, September 8-11, 2015) and invited senior managers of the RM industry for lectures and panel discussions...
November 21, 2016: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/27763972/dermal-matrix-for-intraoral-lining-following-composite-mandibular-defect-reconstruction-with-chimeric-fibular-osseocutaneous-flap
#19
Andreas Gravvanis, Despoina Kakagia, Nick Katsikeris, Dimosthenis Tsoutsos
BACKGROUND: This report aims to first present Integra as an adjunct to complex mandibular reconstruction for intraoral lining resurfacing, and to review the literature on the use of dermal matrices for mucosal resurfacing of the floor of the mouth. CLINICAL REPORT: A 62-year-old female patient with previous ablation surgery for squamous cell carcinoma of the floor of the mouth, presented with extrusion of the mandibular plate through the chin skin and serious tongue tethering...
October 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27734439/fraction-of-inspired-oxygen-delivered-by-elis%C3%A3-e%C3%A2-350-turbine-transport-ventilator-with-a-portable-oxygen-concentrator-in-an-austere-environment
#20
Erwan d'Aranda, Julien Bordes, Boris Bourgeois, Jared Clay, Pierre Esnault, Pierre-Julien Cungi, Philippe Goutorbe, Eric Kaiser, Eric Meaudre
BACKGROUND: Management of critically ill patients in austere environments is a logistic challenge. Availability of oxygen cylinders for the mechanically ventilated patient may be difficult in such a context. One solution is to use a ventilator able to function with an oxygen concentrator (OC). METHODS: We tested two Elisée™ 350 ventilators paired with SeQual Integra 10-OM oxygen concentrators (OC) (Chart Industries, http://www .chartindustries.com) and evaluated the delivered fraction of inspired oxygen (Fio2)...
December 0: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
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