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https://www.readbyqxmd.com/read/28508099/giant-congenital-melanocytic-nevi-and-malignant-transformation-a-case-for-early-radical-intervention
#1
Christopher R Maguire, Ryan Livingston, Gael E Phillips, Roy M Kimble
The purpose of this paper is to highlight the risk of early malignant transformation in infants with giant congenital melanocytic nevi (GN) and demonstrate the potential for earlier intervention with aggressive surgery. We describe the case of a child born with a GN who developed a metastatic melanoma early in life, despite early commencement of resection of the nevus. This is contrasted against a second case of a child in which a more radical management was conducted. Despite early commencement of serial resection of the GN, the first child in this series died of metastatic melanoma prior to complete excision of the nevus...
May 15, 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/28497218/to-evaluate-the-efficacy-of-an-acellular-flowable-matrix-in-comparison-with-a-wet-dressing-for-the-treatment-of-patients-with-diabetic-foot-ulcers-a-randomized-clinical-trial
#2
F Campitiello, M Mancone, A Della Corte, R Guerniero, S Canonico
The authors aimed to evaluate the efficacy of an advanced wound matrix (Integra Flowable Wound Matrix, Integra LifeScience Corp, Plainsboro, NJ, USA) for treating wounds with irregular geometries versus a wet dressing in patients with diabetic foot ulcers. Sixty patients with diabetic foot ulcers (Grades 3 Wagner) were included in this randomized clinical trial. The study was conducted in the General Surgery Unit and Geriatric of the Second University of Naples, Italy, in the last 12 months. Forty-six cases of diabetic foot ulcers were equally and randomly divided into control and test groups...
May 11, 2017: Updates in Surgery
https://www.readbyqxmd.com/read/28496345/glucose-lowering-therapies-adequacy-of-metabolic-control-and-their-relationship-with-comorbid-depression-in-outpatients-with-type-2-diabetes-in-a-tertiary-hospital-in-kenya
#3
Cf Frederick Otieno, Joseph E Kanu, Emma M Karari, Violet Okech-Helu, Mark D Joshi, Kenn Mutai
BACKGROUND: Depression and diabetes mellitus are important comorbid conditions with serious health consequences. When depression and diabetes are comorbid, depression negatively affects self-management activities of diabetes with serious consequences. Relationship between treatment regimens of diabetes, the adequacy of glycemic control, and occurrence of comorbid depression is not known among our patients. PATIENTS AND METHODS: This was a cross-sectional descriptive study at the outpatient diabetes clinic of the Kenyatta National Hospital where 220 ambulatory patients with type 2 diabetes on follow-up were systematically sampled...
2017: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/28493283/the-current-status-of-research-on-the-integration-of-sexual-and-reproductive-health-and-hiv-services
#4
Charlotte E Warren, Susannah H Mayhew, Jonathan Hopkins
Integration of services for sexual and reproductive health (SRH) and HIV has been widely promoted globally in the belief that both clients and health providers benefit through improvements in quality, efficient use of resources, and lower costs, helping to maximize limited health resources and provide comprehensive client-centered care. This article builds on the growing body of research on integrated sexual SRH and HIV services. It brings together critical reviews on issues within the wider SRH and rights agenda and synthesizes recent research on integrated services, drawing on the Integra Initiative and other major research...
May 10, 2017: Studies in Family Planning
https://www.readbyqxmd.com/read/28489207/conversion-of-plastic-surgery-meeting-abstract-presentations-to-full-manuscripts-a-brazilian-perspective
#5
Rafael Denadai, André Silveira Pinho, Hugo Samartine, Rodrigo Denadai, Cassio Eduardo Raposo-Amaral
Objective: to assess the conversion rate of Plastic Surgery meeting abstract presentations to full manuscript publications and examine factors associated with this conversion. Methods: we assessed the abstracts presented at the 47th and 48th Brazilian Congresses of Plastic Surgery by cross-referencing with multiple databases. We analyzed the Abstracts' characteristics associated with full manuscript publications. Results: of the 200 abstracts presented, 50 abstracts were subsequently published in full, giving the conference a conversion rate of 25%...
January 2017: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/28474158/two-stage-rapid-exenteration-reconstruction-to-allow-early-radiation-therapy-for-an-aggressive-orbital-cancer
#6
Sagar Y Patel, Diana A Tamboli, Ronald Mancini
PURPOSE: Describe a novel two-stage orbital exenteration technique using an INTEGRA dermal regeneration matrix. METHODS: A 63-year-old Hispanic male presented with multiple invasive right eyelid masses that incisional biopsy revealed was infiltrative basal cell carcinoma. The patient underwent a right orbital exenteration without lid sparing. An INTEGRA graft was sutured in place to cover the defect at the time of surgery and allowed to vascularize for 3 weeks...
May 4, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28470971/impact-of-integrated-services-on-hiv-testing-a-nonrandomized-trial-among-kenyan-family-planning-clients
#7
Kathryn Church, Charlotte E Warren, Isolde Birdthistle, George B Ploubidis, Keith Tomlin, Weiwei Zhou, James Kimani, Timothy Abuya, Charity Ndwiga, Sedona Sweeney, Susannah H Mayhew
The impact of integrated reproductive health and HIV services on HIV testing and counseling (HTC) uptake was assessed among 882 Kenyan family planning clients using a nonrandomized cohort design within six intervention and six "comparison" facilities. The effect of integration on HTC goals (two tests over two years) was assessed using conditional logistic regression to test four "integration" exposures: a training and reorganization intervention; receipt of reproductive health and HIV services at recruitment; a functional measure of facility integration at recruitment; and a woman's cumulative exposure to functionally integrated care across different facilities over time...
May 4, 2017: Studies in Family Planning
https://www.readbyqxmd.com/read/28423138/intimate-partner-violence-and-maternal-educational-practice
#8
Josianne Maria Mattos da Silva, Marília de Carvalho Lima, Ana Bernarda Ludermir
OBJECTIVE: The objective of this study is to analyze the association between intimate partner violence against women and maternal educational practice directed to children at the beginning of formal education. METHODS: This is a cross-sectional study, carried out between 2013 and 2014, with 631 mother/child pairs, registered in the Family Health Strategy of the Health District II of the city of Recife, State of Pernambuco, Brazil. It integrates a prospective cohort study designed to investigate the consequences of exposure to intimate partner violence in relation to the child who was born between 2005 and 2006...
April 10, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/28419525/method-comparison-and-generation-of-plasma-biochemistry-ris-for-the-white-rhinoceros-on-a-point-of-care-and-wet-chemistry-analyzer
#9
Emma H Hooijberg, Gerhard Steenkamp, Peter Buss, Amelia Goddard
BACKGROUND: Plasma biochemistry analysis may aid the management of White rhinoceros with poaching or other injuries. Analyzer- and species-specific RIs are necessary to evaluate health status and identify abnormalities. OBJECTIVES: The purpose of the study was to perform a comparison study between the IDEXX VetTest and Roche Cobas Integra 400 Plus, and to generate analyzer-specific RIs for White rhinoceros according to published guidelines. METHODS: Comparison was carried out using White rhinoceros plasma samples from healthy and diseased animals...
April 17, 2017: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/28401422/acetate-free-biofiltration-to-remove-fibroblast-growth-factor-23-in-hemodialysis-patients-a-pilot-study
#10
Valeria Cernaro, Silvia Lucisano, Valeria Canale, Annamaria Bruzzese, Daniela Caccamo, Giuseppe Costantino, Michele Buemi, Domenico Santoro
AIM: Serum levels of 32 kDa-phosphaturic hormone fibroblast growth factor 23 (FGF23) rise early in renal failure in order to keep phosphatemia within the normal range; however, this compensatory mechanism itself contributes to chronic kidney disease-mineral bone disorder. High FGF23 is also associated to left ventricular hypertrophy, vascular calcifications and thus increased cardiovascular risk. The aim of this pilot pre-post study was to evaluate the effects of a single hemodiafiltration session with acetate-free biofiltration (AFB) on FGF23 serum levels...
April 11, 2017: Journal of Nephrology
https://www.readbyqxmd.com/read/28378876/potentials-and-limitations-of-integra%C3%A2-flowable-wound-matrix-seeded-with-adipose-tissue-derived-microvascular-fragments
#11
T Später, F S Frueh, M D Menger, M W Laschke
Adipose tissue-derived microvascular fragments (ad-MVF) represent promising vascularisation units for bioengineered Integra® matrix wound dressing (MWD). However, due to the sheet-like structure with small pore sizes, the seeding of this matrix with ad-MVF is mainly limited to its surface. Integra® flowable wound matrix (FWM) may be suitable to achieve a more homogeneous distribution and, thus, improved vascularisation, because this gel-like matrix allows for the direct admixture of ad-MVF during sample preparation...
April 5, 2017: European Cells & Materials
https://www.readbyqxmd.com/read/28372556/a-randomized-cross-over-study-comparing-the-performance-of-hd-integra%C3%A2-central-concentrate-system-versus-pre-produced-concentrate-in-hemodialysis
#12
K Fauziah, K W Go, A Ghazali, M Zaki, T O Lim
BACKGROUND: Pre-produced bicarbonate concentrates (PPC) are still widely used in developing countries despite its cost and risk but Central Concentrate System (CCS) is lacking in data to support its wider adoption. METHODS: We conducted an 8-week randomized crossover study on 16 Hemodialysis machines to compare CCS versus PPC. Performance is assessed by solute concentrations while safety is assessed by microbial count, endotoxin level and adverse event reporting...
April 3, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28336092/physiological-and-biochemical-responses-of-salix-integra-thunb-under-copper-stress-as-affected-by-soil-flooding
#13
Yini Cao, Chuanxin Ma, Guangcai Chen, Jianfeng Zhang, Baoshan Xing
To explore the joint effect of copper (Cu) and flooding on Salix integra Thunb. (S. integra), the physiological and biochemical parameters of the seedlings grown in Cu amended soil (50, 150, 450 mg kg(-1)) with or without the flooding for 60 days were evaluated. The results suggested that the flooding significantly inhibited the root growth in terms of root length and root tips. The Cu exposures of 50 and 150 mg kg(-1) notably enhanced the root growth as compared to the control. Majority of Cu was accumulated in S...
March 21, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28335186/ex-vivo-tissues-engineering-modeling-for-reconstructive-surgery-using-human-adult-adipose-stem-cells-and-polymeric-nanostructured-matrix
#14
Francesco Morena, Chiara Argentati, Eleonora Calzoni, Marino Cordellini, Carla Emiliani, Francesco D'Angelo, Sabata Martino
The major challenge for stem cell translation regenerative medicine is the regeneration of damaged tissues by creating biological substitutes capable of recapitulating the missing function in the recipient host. Therefore, the current paradigm of tissue engineering strategies is the combination of a selected stem cell type, based on their capability to differentiate toward committed cell lineages, and a biomaterial, that, due to own characteristics (e.g., chemical, electric, mechanical property, nano-topography, and nanostructured molecular components), could serve as active scaffold to generate a bio-hybrid tissue/organ...
March 31, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28326683/restoring-full-thickness-defects-with-spray-skin-in-conjunction-with-dermal-regenerate-template-and-split-thickness-skin-grafting-a-pilot-study
#15
Daniel Hammer, Juan L Rendon, Jennifer Sabino, Kerry Latham, Mark E Fleming, Ian L Valerio
Complex, full-thickness soft tissue defects secondary to large burns, trauma and war-related injuries continue to challenge reconstructive surgeons. To achieve positive surgical outcomes in these patient populations, novel approaches are needed to restore the functional, protective and aesthetic properties of skin. Herein, we provide the first report describing the staged use of a dermal regenerate template (DRT) with a spray-on epidermal regenerative modality (spray skin) in addition to autologous split-thickness skin grafting (STSG) in non-burn trauma and compare these results with those of patients treated with DRT and STSG alone...
March 22, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28301031/management-changes-resulting-from-hospital-accreditation
#16
João Lucas Campos de Oliveira, Carmen Silvia Gabriel, Hosanna Pattrig Fertonani, Laura Misue Matsuda
Objective: to analyze managers and professionals' perceptions on the changes in hospital management deriving from accreditation. Method: descriptive study with qualitative approach. The participants were five hospital quality managers and 91 other professionals from a wide range of professional categories, hierarchical levels and activity areas at four hospitals in the South of Brazil certified at different levels in the Brazilian accreditation system. They answered the question "Tell me about the management of this hospital before and after the Accreditation"...
March 2, 2017: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/28291502/skin-regeneration-using-dermal-substrates-that-contain-autologous-cells-and-silver-nanoparticles-to-promote-antibacterial-activity-in-vitro-studies
#17
Michael A J Zieger, Manuel Ochoa, Rahim Rahimi, Gonzalo Campana, Sunil Tholpady, Babak Ziaie, Rajiv Sood
We hypothesized that the addition of silver nanoparticles (AgNP) to a dermal substrate would impart antibacterial properties without inhibiting the proliferation of contained cells. Our in vitro model was based on the commercial substrate, Integra. The substrate was prepared by simple immersion into 0 to 1% suspension of AgNP (75 or 200 nm diameter) followed by rinsing for 20 minutes and sterilization under an ultraviolet C lamp. A total of 10(7) human adipose stem cells per cubic centimeter were injected and after 1 hour, 6 × 10(5) keratinocytes/cm(2) were seeded and cultured for up to 14 days...
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28203511/a-retrospective-look-at-integrating-a-novel-regenerative-medicine-approach-in-plastic-limb-reconstruction
#18
Edgardo R Rodriguez Collazo, Christopher R Rathbone, Brian R Barnes
Full-thickness wounds that have rendered patients candidates for amputation may require techniques that may include a combinatorial approach above traditional standard of care. The purpose of this retrospective study was to evaluate the effectiveness of an innovative approach whereby several therapies were combined to avoid amputation. Patients with full-thickness wounds who were previously recommended for amputation and were treated with the combinatorial approach of muscle flap reconstruction and concentrated bone marrow aspirate, platelet-rich plasma, INTEGRA Wound matrix, vacuum-assisted closure, and split-thickness skin grafts were assessed retrospectively...
January 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28196036/a-prospective-study-of-four-total-ankle-arthroplasty-implants-by-non-designer-investigators
#19
Tina Lefrancois, Alastair Younger, Kevin Wing, Murray J Penner, Peter Dryden, Hubert Wong, Timothy Daniels, Mark Glazebrook
BACKGROUND: There are several types of prostheses available to surgeons when performing a total ankle arthroplasty (TAA). The main objective of this study was to summarize the clinical and functional outcomes of 4 TAA prostheses: the Hintegra implant (Integra LifeSciences), the Agility implant (DePuy), the Mobility implant (DePuy), and the Scandinavian Total Ankle Replacement (STAR) implant (Small Bone Innovations [SBi]). METHODS: Patients were prospectively recruited...
February 15, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28164565/multicenter-evaluation-of-a-new-high-throughput-hba1c-testing-platform
#20
R Imdahl, R Roddiger, E Casis-Saenz
BACKGROUND: This non-interventional, multicenter study with anonymized leftover patient samples was performed to evaluate the reliability and analytical performance of the novel high-throughput HbA1c cobas c 513 analyzer. METHODS: A performance evaluation was carried out at three sites to validate the overall system functionality, user interaction and analytical performance of the new cobas c 513 analyzer using the Tina-quant® HbA1c Gen. 3 assay. RESULTS: HbA1c applications for both whole blood and hemolysate samples show a high precision using both quality control materials and pools of whole blood or hemolysates...
December 1, 2016: Clinical Laboratory
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