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https://www.readbyqxmd.com/read/27903444/design-of-an-elastin-layered-dermal-regeneration-template
#1
Suzanne M Mithieux, Anthony S Weiss
: We demonstrate a novel approach for the production of tunable quantities of elastic fibers. We also show that exogenous tropoelastin is rate-limiting for elastin synthesis regardless of the age of the dermal fibroblast donor. Additionally, we provide a strategy to further enhance synthesis by older cells through the application of conditioned media. We show that this approach delivers an elastin layer on one side of the leading dermal repair template for contact with the deep dermis in order to deliver prefabricated elastic fibers to a physiologically appropriate site during subsequent surgery...
November 26, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27866883/comparison-of-contraction-among-three-dermal-substitutes-morphological-differences-in-scaffolds
#2
Keijiro Hori, Atsuyoshi Osada, Tsukasa Isago, Hiroyuki Sakurai
Various kinds of synthetic dermal substitutes are produced and used in clinical application and contribute to wound bed preparation for subsequent skin grafting. Although their appearance and outcomes are different, the criteria for the selection of proper synthetic dermal substitutes is not well defined yet. In this study, we focused on the contraction of dermal substitutes and compared the morphological differences in scaffolds. A marked contraction was observed with Pelnac(®) compared to Integra(®) and Terudermis(®) in vitro...
November 17, 2016: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/27866363/comparative-of-quercus-spp-and-salix-spp-for-phytoremediation-of-pb-zn-mine-tailings
#3
Xiang Shi, Shufeng Wang, Haijing Sun, Yitai Chen, Dongxue Wang, Hongwei Pan, Yazhu Zou, Jianfeng Liu, Linyu Zheng, Xiulian Zhao, Zeping Jiang
A pot experiment was conducted to evaluate the feasibility of using tree seedlings for the phytoremediation of lead/zinc (Pb/Zn) mine tailings. Seedlings of three Quercus spp. (Q. shumardii, Q. phellos, and Q. virginiana) and rooted cuttings of two Salix spp. (S. matsudana and S. integra) were transplanted into pots containing 50 and 100 % Pb/Zn mine tailings to evaluate their tolerance of heavy metals. The five species showed different tolerance levels to the Pb/Zn tailings treatments. Q. virginiana was highly tolerant to heavy metals and grew normally in the Pb/Zn tailings...
November 19, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27862914/in-vivo-biocompatibility-vascularization-and-incorporation-of-integra-%C3%A2-dermal-regenerative-template-and-flowable-wound-matrix
#4
Thomas Später, Florian S Frueh, Wolfgang Metzger, Michael D Menger, Matthias W Laschke
Integra(®) matrix wound dressing (MWD) is used for the reconstruction of full-thickness skin defects. For the treatment of complex wounds, this dermal substitute is available as a flowable wound matrix (FWM) of identical composition. To clarify whether variations in sample preparation and consistency affect the biocompatibility and tissue incorporation, we herein compared MWD and FWM. The matrices were characterized using scanning electron microscopy and histology. Moreover, they were implanted in mouse dorsal skinfold chambers to analyze their in vivo performance over 2 weeks...
November 14, 2016: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/27836621/analytical-performance-of-three-whole-blood-point-of-care-lactate-devices-compared-to-plasma-lactate-comparison-methods-and-a-flow-injection-mass-spectrometry-method
#5
Nicole V Tolan, Amy M Wockenfus, Christopher D Koch, Bridgit O Crews, Dennis J Dietzen, Brad S Karon
OBJECTIVES: Point of care (POC) whole blood lactate testing may facilitate rapid detection of sepsis. We evaluated three POC methods against both plasma lactate comparison methods and a flow-injection mass spectrometric (MS) method. DESIGN AND METHODS: Nova StatStrip, Abbott i-STAT CG4+ and Radiometer ABL90 POC lactate methods were evaluated against the mean of Cobas Integra 400 and Vitros 350 plasma lactate. POC methods were also compared to a flow-injection mass spectrometric assay measuring lactate in ZnSO4-precipitated whole blood extracts...
November 9, 2016: Clinical Biochemistry
https://www.readbyqxmd.com/read/27826471/integra-based-reconstruction-of-large-scalp-wounds-a-case-report-and-systematic-review-of-the-literature
#6
Maxwell B Johnson, Alex K Wong
BACKGROUND: Large complex scalp wounds that have traditionally required free vascularized tissue transfer have been successfully reconstructed with skin substitutes such as Integra. Although there are multiple reports of Integra-based reconstructions of scalp wounds, there has not been a comprehensive assessment of this body of literature that critically examines this method. Our goal was to conduct a systematic review to determine the effectiveness of Integra-based reconstructions of scalp wounds, with emphasis on large defects...
October 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/27826090/subdural-empyema-in-the-setting-of-multimodal-intracranial-monitoring
#7
Jian Guan, Emily S Spivak, Christopher Wilkerson, Min S Park
BACKGROUND: Multimodal intracranial monitoring is becoming an increasingly common tool in the management of patients with traumatic brain injury. Although numerous reports detailing the benefits of such advanced monitoring exist in the literature, there is minimal discussion of the possible complications that may arise in this patient population. CASE DESCRIPTION: We report the case of a 32-year-old patient who had been assaulted and presented initially at an outside facility with a Glasgow Coma Scale score of 8...
November 5, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27810611/management-of-skin-defect-following-resection-of-stage-iv-scalp-melanoma-a-case-report
#8
Yana Puckett, Eileen Bui, Sharmila Dissanaike
INTRODUCTION: Surgical defect left following excision of a large and neglected scalp melanoma of can pose a significant challenge for the surgeon. Scalp reconstruction encompasses options such as skin flaps, grafts, and various mechanical techniques. In scalp excision that involves dissection beyond the galea, skin grafts and flaps may not take well and not enough tissue may be available for a skin flap. PRESENTATION OF CASE: We present the case of a 64 year-old male with a giant scalp melanoma...
October 17, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27779431/acellular-dermal-matrix-new-applications-for-free-flap-pedicle-coverage-a-prospective-study-in-10-patients
#9
Franck Leclère, Emilie Desnouveaux, Vincent Casoli
INTRODUCTION: The goal of lower extremity reconstruction after trauma is the coverage of defects to give patients a healed wound and to let them resume their life, ambulate, and return to work while preventing amputation. In this article we describe an innovative use of Integra® for free flap pedicle coverage in lower extremity reconstruction. MATERIALS AND METHODS: Between January 2011 and December 2015, ten patients, 4 women and 6 men, underwent a lower limb reconstruction with an association of free flap and integra® to cover the flap pedicle...
October 25, 2016: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/27771996/how-regenerative-medicine-stakeholders-adapt-to-ever-changing-technology-and-regulatory-challenges-snapshots-from-the-world-termis-industry-symposium-september-10-2015-boston
#10
Yves Bayon, Mark Van Dyke, Robert Buelher, Ross Tubo, Tim Bertram, Bernard Malfroy-Camine, Michelle Rathman, Vincent Ronfard
Regenerative medicine (RM) is a fascinating area of research and innovation. The huge potential of the field has been fairly underexploited so far. Both TERMIS-AM and TERMIS-EU Industry Committees are committed to mentoring and training young entrepreneurs for more successful commercial translation of upstream research. With this objective in mind, the two entities jointly organized an industry symposium during the past TERMIS World Congress (Boston, September 8-11, 2015) and invited senior managers of the RM industry for lectures and panel discussions...
November 21, 2016: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/27763972/dermal-matrix-for-intraoral-lining-following-composite-mandibular-defect-reconstruction-with-chimeric-fibular-osseocutaneous-flap
#11
Andreas Gravvanis, Despoina Kakagia, Nick Katsikeris, Dimosthenis Tsoutsos
BACKGROUND: This report aims to first present Integra as an adjunct to complex mandibular reconstruction for intraoral lining resurfacing, and to review the literature on the use of dermal matrices for mucosal resurfacing of the floor of the mouth. CLINICAL REPORT: A 62-year-old female patient with previous ablation surgery for squamous cell carcinoma of the floor of the mouth, presented with extrusion of the mandibular plate through the chin skin and serious tongue tethering...
October 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27734439/fraction-of-inspired-oxygen-delivered-by-elis%C3%A3-e%C3%A2-350-turbine-transport-ventilator-with-a-portable-oxygen-concentrator-in-an-austere-environment
#12
Erwan d'Aranda, Julien Bordes, Boris Bourgeois, Jared Clay, Pierre Esnault, Pierre-Julien Cungi, Philippe Goutorbe, Eric Kaiser, Eric Meaudre
BACKGROUND: Management of critically ill patients in austere environments is a logistic challenge. Availability of oxygen cylinders for the mechanically ventilated patient may be difficult in such a context. One solution is to use a ventilator able to function with an oxygen concentrator (OC). METHODS: We tested two Elisée™ 350 ventilators paired with SeQual Integra 10-OM oxygen concentrators (OC) (Chart Industries, http://www .chartindustries.com) and evaluated the delivered fraction of inspired oxygen (Fio2)...
2016: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
https://www.readbyqxmd.com/read/27716800/re-evaluation-of-phylogenetic-relationships-among-species-of-the-mangrove-genus-avicennia-from-indo-west-pacific-based-on-multilocus-analyses
#13
Xinnian Li, Norman C Duke, Yuchen Yang, Lishi Huang, Yuxiang Zhu, Zhang Zhang, Renchao Zhou, Cairong Zhong, Yelin Huang, Suhua Shi
Avicennia L. (Avicenniaceae), one of the most diverse mangrove genera, is distributed widely in tropical and subtropical intertidal zones worldwide. Five species of Avicennia in the Indo-West Pacific region have been previously described. However, their phylogenetic relationships were determined based on morphological and allozyme data. To enhance our understanding of evolutionary patterns in the clade, we carried out a molecular phylogenetic study using wide sampling and multiple loci. Our results support two monophyletic clades across all species worldwide in Avicennia: an Atlantic-East Pacific (AEP) lineage and an Indo-West Pacific (IWP) lineage...
2016: PloS One
https://www.readbyqxmd.com/read/27699461/the-use-of-integra-dermal-regeneration-template-versus-flaps-for-reconstruction-of-full-thickness-scalp-defects-involving-the-calvaria-a-cost-benefit-analysis
#14
M Schiavon, M Francescon, D Drigo, G Salloum, R Baraziol, J Tesei, E Fraccalanza, F Barbone
BACKGROUND: INTEGRA(®) Dermal Regeneration Template is a well-known and widely used acellular dermal matrix. Although it helps to solve many challenging problems in reconstructive surgery, the product cost may make it an expensive alternative compared to other reconstruction procedures. This retrospective study aims at comparing INTEGRA-based treatment to flap surgery in terms of cost and benefit. PATIENTS AND METHODS: We considered only patients treated for scalp defects with bone exposure in order to obtain two groups as homogeneous as possible...
December 2016: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/27696973/tracheal-tissue-engineering-in-vivo-biocompatibility-of-mechanically-stripped-allogenic-rabbit-trachea-with-autologous-epithelial-covering
#15
Margot Den Hondt, Bart M Vanaudenaerde, Erik K Verbeken, Jan J Vranckx
BACKGROUND: Successful trachea transplantation comprises the use of biocompatible constructs with little immune-reactivity, submucosal revascularization and creation of an epithelial covering. Allogenic chondrocytes might be protected from an overt immune-response due to physical isolation. Our aim was to evaluate in-vivo biocompatibility of allotracheae, stripped of their highly-immunogenic inner lining. Secondly, we established whether these constructs might serve as suitable scaffolds for autologous epithelial grafting...
October 4, 2016: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/27664335/erroneous-hba1c-results-in-a-patient-with-elevated-hbc-and-hbf
#16
Joy Adekanmbi, Trefor Higgins, Karina Rodriguez-Capote, Dylan Thomas, Jeffrey Winterstein, Tara Dixon, Jessica L Gifford, Richard Krause, Allison A Venner, Gwen Clarke, Mathew P Estey
BACKGROUND: HbA1c is used in the diagnosis and monitoring of diabetes mellitus (DM). Interference from hemoglobin variants is a well-described phenomenon, particularly with HPLC-based methods. While immunoassays may generate more reliable HbA1c results in the presence of some variants, these methods are susceptible to negative interference from high concentrations of HbF. We report a case where an accurate HbA1c result could not be obtained by any available method due to the presence of a compound hemoglobinopathy...
November 1, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/27639479/phylogenetic-relationships-of-proboscoida-broch-1910-cnidaria-hydrozoa-are-traditional-morphological-diagnostic-characters-relevant-for-the-delimitation-of-lineages-at-the-species-genus-and-family-levels
#17
Amanda F Cunha, Allen G Collins, Antonio C Marques
Overlapping variation of morphological characters can lead to misinterpretation in taxonomic diagnoses and the delimitation of different lineages. This is the case for hydrozoans that have traditionally been united in the family Campanulariidae, a group known for its wide morphological variation and complicated taxonomic history. In a recently proposed phylogenetic classification of leptothecate hydrozoans, this family was restricted to a more narrow sense while a larger clade containing most species traditionally classified in Campanulariidae, along with members of Bonneviellidae, was established as the suborder Proboscoida...
September 14, 2016: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/27598376/critical-thinking-concept-analysis-from-the-perspective-of-rodger-s-evolutionary-method-of-concept-analysis
#18
Fábio da Costa Carbogim, Larissa Bertacchini de Oliveira, Vilanice Alves de Araújo Püschel
OBJECTIVE: to analyze the concept of critical thinking (CT) in Rodger's evolutionary perspective. METHOD: documentary research undertaken in the Cinahl, Lilacs, Bdenf and Dedalus databases, using the keywords of 'critical thinking' and 'Nursing', without limitation based on year of publication. The data were analyzed in accordance with the stages of Rodger's conceptual model. The following were included: books and articles in full, published in Portuguese, English or Spanish, which addressed CT in the teaching and practice of Nursing; articles which did not address aspects related to the concept of CT were excluded...
2016: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/27586397/viscoelastic-physical-and-bio-degradable-properties-of-dermal-scaffolds-and-related-cell-behaviour
#19
Vaibhav Sharma, Nimesha Patel, Nupur Kohli, Nivedita Ravindran, Lilian Hook, Chris Mason, Elena García-Gareta
Dermal scaffolds promote healing of debilitating skin injuries caused by burns and chronic skin conditions. Currently available products present disadvantages and therefore, there is still a clinical need for developing new dermal substitutes. This study aimed at comparing the viscoelastic, physical and bio-degradable properties of two dermal scaffolds, the collagen-based and clinically well established Integra(®) and a novel fibrin-based dermal scaffold developed at our laboratory called Smart Matrix(®), to further evaluate our previous published findings that suggested a higher influx of cells, reduced wound contraction and less scarring for Smart Matrix(®) when used in vivo...
2016: Biomedical Materials
https://www.readbyqxmd.com/read/27574682/post-burn-breast-reconstruction-using-an-artificial-dermis-a-long-term-follow-up
#20
Yoav Gronovich, Adi Maisel Lotan, Meir Retchkiman
BACKGROUND: Full thickness burns of the chest in childhood are a devastating problem that requires challenging reconstructive options. Integra is a bilaminate artificial dermis composed of shark chondroitin 6-sulfate and bovine collagen. The dermal matrix serves as a scaffold for fibroblasts and endothelial cells. Vascularization of the matrix begins after 2-3 weeks, and eventually, the matrix incorporates with the tissue to create a new dermis. The main advantage of the Integra is that the neodermis is of the same quality as a native dermis...
2016: Burns and trauma
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