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Neuromuscular control

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https://www.readbyqxmd.com/read/28730486/phosphoproteomic-analysis-of-isolated-mitochondria-in-yeast
#1
Margaux Renvoisé, Ludovic Bonhomme, Marlène Davanture, Michel Zivy, Claire Lemaire
Mitochondria play a central role in cellular energy metabolism and cell death. Deregulation of mitochondrial functions is associated with several human pathologies (neurodegenerative diseases, neuromuscular diseases, type II diabetes, obesity, cancer). The steadily increasing number of identified mitochondrial phosphoproteins, kinases, and phosphatases in recent years suggests that reversible protein phosphorylation plays an important part in the control of mitochondrial processes. In addition, many mitochondrial phosphoproteins probably still remain to be identified, considering that 30% of proteins are expected to be phosphorylated in eukaryotes...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28729214/milk-fat-globule-membrane-supplementation-with-voluntary-running-exercise-attenuates-age-related-motor-dysfunction-by-suppressing-neuromuscular-junction-abnormalities-in-mice
#2
Michiko Yano, Yoshihiko Minegishi, Satoshi Sugita, Noriyasu Ota
Age-related loss of skeletal muscle mass and function attenuates physical performance, and maintaining fine muscle innervation is known to play an important role in its prevention. We had previously shown that consumption of milk fat globule membrane (MFGM) with habitual exercise improves the muscle mass and motor function in humans and mice. Improvement of neuromuscular junction (NMJ) was suggested as one of the mechanisms underlying these effects. In this study, we evaluated the effect of MFGM intake combined with voluntary running (MFGM-VR) on morphological changes of NMJ and motor function in aging mice...
July 17, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28728956/ataluren-in-patients-with-nonsense-mutation-duchenne-muscular-dystrophy-act-dmd-a-multicentre-randomised-double-blind-placebo-controlled-phase-3-trial
#3
Craig M McDonald, Craig Campbell, Ricardo Erazo Torricelli, Richard S Finkel, Kevin M Flanigan, Nathalie Goemans, Peter Heydemann, Anna Kaminska, Janbernd Kirschner, Francesco Muntoni, Andrés Nascimento Osorio, Ulrike Schara, Thomas Sejersen, Perry B Shieh, H Lee Sweeney, Haluk Topaloglu, Már Tulinius, Juan J Vilchez, Thomas Voit, Brenda Wong, Gary Elfring, Hans Kroger, Xiaohui Luo, Joseph McIntosh, Tuyen Ong, Peter Riebling, Marcio Souza, Robert J Spiegel, Stuart W Peltz, Eugenio Mercuri
BACKGROUND: Duchenne muscular dystrophy (DMD) is a severe, progressive, and rare neuromuscular, X-linked recessive disease. Dystrophin deficiency is the underlying cause of disease; therefore, mutation-specific therapies aimed at restoring dystrophin protein production are being explored. We aimed to assess the efficacy and safety of ataluren in ambulatory boys with nonsense mutation DMD. METHODS: We did this multicentre, randomised, double-blind, placebo-controlled, phase 3 trial at 54 sites in 18 countries located in North America, Europe, the Asia-Pacific region, and Latin America...
July 17, 2017: Lancet
https://www.readbyqxmd.com/read/28724748/depressed-synaptic-transmission-and-reduced-vesicle-release-sites-in-huntington-s-disease-neuromuscular-junctions
#4
Ahmad Khedraki, Eric J Reed, Shannon H Romer, Qingbo Wang, William Romine, Mark M Rich, Robert J Talmadge, Andrew A Voss
Huntington's disease (HD) is a progressive and fatal degenerative disorder that results in debilitating cognitive and motor dysfunction. Most HD studies have focused on degeneration of the central nervous system. We previously discovered that skeletal muscle from transgenic R6/2 HD mice is hyperexcitable due to decreased chloride and potassium conductances. The progressive and early onset of these defects suggest a primary myopathy in HD. In this study, we examined the relationship between neuromuscular transmission and skeletal muscle hyperexcitability...
July 19, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28723717/localized-muscle-vibration-reverses-quadriceps-muscle-hypotrophy-and-improves-physical-function-a-clinical-and-electrophysiological-study
#5
Maria Grazia Benedetti, Gennaro Boccia, Lorenzo Cavazzuti, Elena Magnani, Elisabetta Mariani, Alberto Rainoldi, Roberto Casale
Quadriceps weakness has been associated with knee osteoarthritis (OA). High-frequency localized muscle vibration (LMV) has been proposed recently for quadriceps strengthening in patients with knee OA. The purpose of this study was (a) to investigate the clinical effectiveness of high-frequency LMV on quadriceps muscle in patients with knee OA and (b) to disentangle, by means of surface electromyography (sEMG), the underlying mechanism. Thirty patients, aged between 40 and 65 years, and clinically diagnosed with knee OA were included in this randomized, controlled, single-blinded pilot study...
July 18, 2017: International Journal of Rehabilitation Research. Revue Internationale de Recherches de Réadaptation
https://www.readbyqxmd.com/read/28717621/effects-of-the-menstrual-cycle-on-lower-limb-biomechanics-neuromuscular-control-and-anterior-cruciate-ligament-injury-risk-a-systematic-review
#6
REVIEW
Vivek Balachandar, Jan-Luigi Marciniak, Owen Wall, Chandrika Balachandar
OBJECTIVE: Anterior cruciate ligament (ACL) injury has a devastating impact on physical and psychological disability. Rates of ACL rupture are significantly greater in females than males during the same sports. Hormonal mechanisms have been proposed but are complex and poorly understood. This systematic review evaluates the effects of menstrual cycle on: 1) lower-limb biomechanics, 2) neuromuscular control, and 3) ACL injury risk. METHODS: The MEDLINE, CINAHL, SPORTSDiscus, Web of Science, and Google Scholar databases were searched from inception to August 2016 for studies investigating the effects of the menstrual cycle on lower-limb biomechanics, neuromuscular control, and ACL injury risk in females...
January 2017: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/28715302/characterization-of-humeral-head-displacements-during-dynamic-glenohumeral-neuromuscular-control-exercises-using-quantitative-ultrasound-imaging-a-feasibility-study
#7
Guillaume Desroches, François Desmeules, Dany H Gagnon
The objectives of the present study were to test the feasibility of measuring humeral head displacements using quantitative ultrasound imaging during the performance of two different dynamic glenohumeral neuromuscular control exercises and to investigate the influence of these exercises on the acromiohumeral distance (AHD) and anterior-posterior distance (APD). Ten individuals who have no history of shoulder injury at the non-dominant shoulder completed three repetitions of an active humeral head lowering exercise and three repetitions of a posteriorisation exercise in a random order in a seated position...
June 2017: Musculoskeletal Science & Practice
https://www.readbyqxmd.com/read/28714764/abdominal-hollowing-reduces-lateral-trunk-displacement-during-single-leg-squats-in-healthy-females-but-does-not-affect-peak-hip-abduction-angle-or-knee-abductio-angle-moment
#8
Lukas D Linde, Jessica Archibald, Eve C Lampert, John Z Srbely
CONTEXT: Females suffer 4-6 times more non-contact anterior cruciate ligament (ACL) injuries than males due to neuromuscular control deficits of the hip musculature leading to increases in hip adduction angle, knee abduction angle, and knee abduction moment during dynamic tasks such as single-leg squats. Lateral trunk displacement has been further related to ACL injury risk in females, leading to the incorporation of core strength/stability exercises in ACL preventative training programs...
July 17, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/28711998/medical-history-of-chemotherapy-or-immunosuppressive-drug-treatment-and-risk-of-amyotrophic-lateral-sclerosis-als
#9
Thomas Kuczmarski, Elijah W Stommel, Kristen Riley, Rup Tandan, Vinay Chaudhry, Lora Clawson, Tracie A Caller, Patricia L Henegan, Dominic N Facciponte, Walter G Bradley, Angeline S Andrew
A recent population-based analysis demonstrated lower risk of the lethal degenerative neuromuscular disease, amyotrophic lateral sclerosis (ALS) associated with history of the use of 'antineoplastic agents' and 'immunosuppressants'. To see if this finding was generalizable to other ALS cohorts, we examined associations between use of these agents and ALS risk in an independent case-control study of n = 414 ALS patients and n = 361 controls in an Eastern US population. Controls were sampled from the general population and among non-neurodegenerative disease patients...
July 15, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28710284/the-neuronal-protein-neurexin-directly-interacts-with-the-scribble-pix-complex-to-stimulate-f-actin-assembly-for-synaptic-vesicle-clustering
#10
Menglong Rui, Jinjun Qian, Lijuan Liu, Yihan Cai, Huihui Lv, Junhai Han, Zhengping Jia, Wei Xie
Synaptic vesicles (SVs) form distinct pools at synaptic terminals, and this well-regulated separation is necessary for normal neuro-transmission. However, how SV cluster in particular synaptic compartments to maintain normal neurotransmitter release remains a mystery. The presynaptic protein Neurexin (NRX) plays a significant role in synaptic architecture and function, and some evidences suggest that NRX is associated with neurological disorders, including autism spectrum disorders. However, the role of NRX in SV clustering is unclear...
July 14, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28708702/exercise-induced-fatigue-in-severe-hypoxia-following-an-intermittent-hypoxic-protocol
#11
Rosie Twomey, James Wrightson, Hannah Fletcher, Stephanie Avraam, Emma Ross, Jeanne Dekerle
PURPOSE: Exercise-induced central fatigue is alleviated following acclimatisation to high altitude. The adaptations underpinning this effect may also be induced with brief, repeated exposures to severe hypoxia. The purpose of this study was to determine whether (i) exercise tolerance in severe hypoxia would be improved following an intermittent hypoxic (IH) protocol and (ii) exercise-induced central fatigue would be alleviated following an IH protocol. METHODS: Nineteen recreationally-active males were randomised into two groups who completed ten 2-h exposures in severe hypoxia (IH: PIO2 82 mmHg; n=11) or normoxia (control; n=8)...
July 13, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28708701/self-reported-concussion-history-and-sensorimotor-tests-predict-head-neck-injuries
#12
Julie A Hides, Melinda M Franettovich Smith, M Dilani Mendis, Julia Treleaven, Andrew H Rotstein, Christopher T Sexton, Nancy Low Choy, Paul McCrory
PURPOSE: Sports related concussion (SRC) is a risk for players involved in high impact, collision sports. A history of SRC is a risk factor for future concussions, but the mechanisms underlying this are unknown. Despite evidence that most visible signs and symptoms associated with sports concussion resolve within 7-10 days, it has been proposed that subclinical loss of neuromuscular control and impaired motor functioning may persist and be associated with further injury. Alternatively, indicators of poor sensorimotor performance could be independent risk factors...
July 13, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28704884/prone-hip-extension-muscle-recruitment-is-associated-with-hamstring-injury-risk-in-amateur-soccer
#13
Joke Schuermans, Damien Van Tiggelen, Erik Witvrouw
'Core stability' is considered essential in rehabilitation and prevention. Particularly with respect to hamstring injury prevention, assessment and training of lumbo-pelvic control is thought to be key. However, supporting scientific evidence is lacking. To explore the importance of proximal neuromuscular function with regard to hamstring injury susceptibility, this study investigated the association between the Prone Hip Extension (PHE) muscle activation pattern and hamstring injury incidence in amateur soccer players...
July 13, 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/28704882/neuromuscular-adaptations-to-combined-strength-and-endurance-training-order-and-time-of-day
#14
Maria Küüsmaa-Schildt, Daniela Eklund, Janne Avela, Tuomas Rytkönen, Robert Newton, Mikel Izquierdo, Keijo Häkkinen
The present study examined the effects of 24 weeks of morning vs. evening same-session combined strength (S) and endurance (E) training on neuromuscular and endurance performance. Fifty-one men were assigned to the morning (m) or evening (e) training group, where S preceded E or vice versa (SEm, ESm, SEe and ESe), or to the control group. Isometric force, voluntary activation, EMG and peak wattage during the maximal cycling test were measured. Training time did not significantly affect the adaptations. Therefore, data are presented for SEm+e (SEm+SEe) and ESm+e (ESm+ESe)...
July 13, 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/28704311/acute-neuromuscular-and-endocrine-responses-to-two-different-compound-exercises-squat-versus-deadlift
#15
Matthew J Barnes, Adam Miller, Daniel Reeve, Robin Jc Stewart
Anecdotally, it is believed that the deadlift exercise brings about greater levels of central fatigue than other exercises; however no empirical evidence exists to support this view. Additionally, little is known about the acute endocrine response to heavy deadlift exercise and how this may differ to other similar compound exercises. Therefore, the aim of this study was to identify and compare the acute, neuromuscular and endocrine responses to squat and deadlift exercise. Ten resistance trained males completed 8 sets of 2 repetitions at 95 % of one repetition maximum...
July 12, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28702446/comparison-of-abdominal-muscle-activity-during-abdominal-drawing-in-maneuver-combined-with-irradiation-variations
#16
Young-In Hwang, Du-Jin Park
Many experts have used an indirect method for enhancing strength and performance of muscles in clinical practice. The indirect method, which called an irradiation is a basic procedure of proprioceptive neuromuscular facilitation, there is little research related the effects of irradiation. This study investigated abdominal muscle activity during abdominal drawing-in maneuver (ADIM) combined with irradiation variations. The study recruited 42 healthy, young adults who were divided randomly into three groups according to which intervention they received...
June 2017: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/28698474/a-novel-spatial-feature-for-the-identification-of-motor-tasks-using-high-density-electromyography
#17
Mislav Jordanić, Mónica Rojas-Martínez, Miguel Angel Mañanas, Joan Francesc Alonso, Hamid Reza Marateb
Estimation of neuromuscular intention using electromyography (EMG) and pattern recognition is still an open problem. One of the reasons is that the pattern-recognition approach is greatly influenced by temporal changes in electromyograms caused by the variations in the conductivity of the skin and/or electrodes, or physiological changes such as muscle fatigue. This paper proposes novel features for task identification extracted from the high-density electromyographic signal (HD-EMG) by applying the mean shift channel selection algorithm evaluated using a simple and fast classifier-linear discriminant analysis...
July 8, 2017: Sensors
https://www.readbyqxmd.com/read/28687442/increased-bace1-activity-inhibits-peripheral-nerve-regeneration-after-injury
#18
Carolyn Tallon, Edward Rockenstein, Eliezer Masliah, Mohamed H Farah
Axons of the peripheral nervous system possess the capacity to regenerate following injury. Previously, we showed that genetically knocking out Beta-Site APP-Cleaving Enzyme 1 (BACE1) leads to increased nerve regeneration. Two cellular components, macrophages and neurons, contribute to enhanced nerve regeneration in BACE1 knockout mice. Here, we utilized a transgenic mouse model that overexpresses BACE1 in its neurons to investigate whether neuronal BACE1 has an inverse effect on regeneration following nerve injury...
July 5, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/28682215/could-slackline-training-complement-the-fifa-11-programme-regarding-training-of-neuromuscular-control
#19
Tobias Jäger, Julian Kiefer, Inge Werner, Peter A Federolf
The current study compared changes in neuromuscular control between slackline training and the stabilization training elements of the FIFA 11+ programme. Twenty-five students in 2 groups performed a 12-unit training programme. The slackline training group (n = 13) exclusively trained with a slackline. The stabilization training group (n = 12) practised exercises as described in the second part of the FIFA 11+ programme. Improvements in balance were assessed using three tests for dynamic, quasi-static, and perturbed postural control: the star excursion balance test (SEBT), the closed-eye single-leg stance, and the MFT S3-Check...
July 6, 2017: European Journal of Sport Science
https://www.readbyqxmd.com/read/28678768/effects-of-lower-limb-strength-training-on-agility-repeated-sprinting-with-changes-of-direction-leg-peak-power-and-neuromuscular-adaptations-of-soccer-players
#20
Mehréz Hammami, Yassine Negra, François Billaut, Souhail Hermassi, Roy J Shephard, Mohamed Souhaiel Chelly
We examined the effects on explosive muscular performance of incorporating 8 weeks strength training into the preparation of junior male soccer players, allocating subjects between an experimental group (E, n=19) and a matched control group (C, n=12). Controls maintained their regular training program, but the experimental group replaced a part of this schedule by strength training. Performance was assessed using running times (5m, 10m, 20m, 30 and 40m), a sprint test with 180° turns (S180°), a 9-3-6-3-9 m sprint with backward and forward running (SBF), a 4 x 5 m sprint test with turns, repeated shuttle sprinting, repeated changes of direction, squat (SJ) and counter-movement (CMJ) jumping, back half-squatting, and a force-velocity test...
January 24, 2017: Journal of Strength and Conditioning Research
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