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https://www.readbyqxmd.com/read/29673285/tlr-agonist-combinations-that-stimulate-th-type-i-polarizing-responses-from-human-neonates
#1
Naveen Surendran, Andrea Simmons, Michael E Pichichero
Each year millions of neonates die due to vaccine preventable infectious diseases. Our study seeks to develop novel neonatal vaccines and improve immunogenicity of early childhood vaccines by incorporating TLR agonist-adjuvant combinations that overcome the inherent neonatal Th2 bias and stimulate Th1 polarizing response from neonatal APCs. We systematically stimulated cord blood mononuclear cells with single and multiple combinations of TLR agonists and measured levels of IL-12p70, IFN-γ, IFN-α, IL-10, IL-13, TNF-α, IL-6 and IL-1β from cell culture supernatants...
January 1, 2018: Innate Immunity
https://www.readbyqxmd.com/read/29643191/cd83-antibody-inhibits-human-b-cell-responses-to-antigen-as-well-as-dendritic-cell-mediated-cd4-t-cell-responses
#2
Kuan Y Wong, Rebecca Baron, Therese A Seldon, Martina L Jones, Alison M Rice, David J Munster
Anti-CD83 Ab capable of Ab-dependent cellular cytotoxicity can deplete activated CD83+ human dendritic cells, thereby inhibiting CD4 T cell-mediated acute graft-versus-host disease. As CD83 is also expressed on the surface of activated B lymphocytes, we hypothesized that anti-CD83 would also inhibit B cell responses to stimulation. We found that anti-CD83 inhibited total IgM and IgG production in vitro by allostimulated human PBMC. Also, Ag-specific Ab responses to immunization of SCID mice xenografted with human PBMC were inhibited by anti-CD83 treatment...
April 11, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29617044/pcsk9-plays-a-novel-immunological-role-in-the-oxidized-ldl-induced-dendritic-cell-maturation-and-t-cell-activation-from-human-blood-and-atherosclerotic-plaque
#3
Anquan Liu, Johan Frostegård
BACKGROUND: Activated T cells and dendritic cells (DCs) occur in atherosclerotic plaques. Proprotein convertase subtilisin kexin 9 (PCSK9) targets the LDL-receptor (LDLR), and results in increased LDL-levels. We here investigate immune effects of PCSK9 on OxLDL induced DC maturation and T cell activation. METHODS: T cells were isolated from carotid specimens of patients undergoing carotid endarterectomy, or from peripheral blood of healthy individuals. Human peripheral blood monocytes were differentiated into DCs...
April 4, 2018: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29581231/intestinal-mucin-activates-human-dendritic-cells-and-il-8-production-in-a-glycan-specific-manner
#4
Felipe Melo-Gonzalez, Thomas M Fenton, Cecilia Forss, Catherine Smedley, Anu Goenka, Andrew S MacDonald, David J Thornton, Mark A Travis
Cross-talk between different components of the intestinal barrier and the immune system may be important in maintaining gut homeostasis. A crucial part of the gut barrier is the mucus layer, a cross-linked gel on top of the intestinal epithelium that consists predominantly of the mucin glycoprotein MUC2. However, whether the mucin layer actively regulates intestinal immune cell responses is not clear. As recent evidence suggests that intestinal dendritic cells (DCs) may be regulated by the mucus layer, we purified intestinal mucin, incubated with human DCs and determined functional effects...
March 26, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29572346/cd83-in-hodgkin-lymphoma
#5
EDITORIAL
Ralf Küppers
No abstract text is available yet for this article.
April 2018: Haematologica
https://www.readbyqxmd.com/read/29571039/interleukin-35-inhibitory-regulator-in-monocyte-derived-dendritic-cell-maturation-and-activation
#6
Xi Chen, Shengnan Hao, Zhonghua Zhao, Jia Liu, Qianqian Shao, Fang Wang, Dong Sun, Ying He, Wenjuan Gao, Haiting Mao
IL-35, a novel IL-12 family member, is a potent inhibitory cytokine predominantly produced by regulatory T and B lymphocytes that exerts optimal suppression in immune response. However, it remains unclear whether IL-35 plays an inhibitory role on human dendritic cells. In the present study, we focused on the possible immunosuppressive effect of IL-35 on the differentiation, maturation and function of monocyte-derived DCs (MoDCs). Addition of exogenous IL-35 was able to partially suppress MoDCs differentiation in vitro...
March 20, 2018: Cytokine
https://www.readbyqxmd.com/read/29569735/anisakis-pegreffii-impacts-differentiation-and-function-of-human-dendritic-cells
#7
Chiara Napoletano, Simonetta Mattiucci, Alessandra Colantoni, Federico Battisti, Ilaria Grazia Zizzari, Hassan Rahimi, Marianna Nuti, Aurelia Rughetti
Human dendritic cells (DCs) show remarkably phenotypic changes when matured in presence of helminth-derived products. These modifications frequently elicited a polarization towards Th2 cells and regulatory T cells thus contributing to immunological tolerance against these pathogens. In this study, the interaction between DCs and larvae of the zoonotic anisakid nematode Anisakis pegreffii was investigated. A. pegreffii larvae were collected from fish hosts and monocyte derived DCs were co-cultured in the presence of the live larvae (L) or its crude extracts (CE)...
March 23, 2018: Parasite Immunology
https://www.readbyqxmd.com/read/29565746/packed-red-blood-cell-transfusion-modulates-myeloid-dendritic-cell-activation-and-inflammatory-response-in-vitro
#8
Katrina K Ki, Helen M Faddy, Robert L Flower, Melinda M Dean
Transfusion of packed red blood cells (PRBCs) modulates patients' immune responses and clinical outcomes; however, the underpinning mechanism(s) remain unknown. The potential for PRBC to modulate myeloid dendritic cells (mDC) and blood DC antigen 3 was assessed using an in vitro transfusion model. In parallel, to model processes activated by viral or bacterial infection, toll-like receptor agonists polyinosinic:polycytidylic acid or lipopolysaccharide were added. Exposure to PRBC upregulated expression of CD83 and downregulated CD40 and CD80 on both DC subsets, and it suppressed production of interleukin (IL)-6, IL-8, IL-12, tumor necrosis factor-α, and interferon-gamma-inducible protein-10 by these cells...
March 2018: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/29545920/hypoxia-enhances-indoleamine-2-3-dioxygenase-production-in-dendritic-cells
#9
Xiang Song, Yan Zhang, Li Zhang, Wengang Song, Lixin Shi
Hypoxia-associated metabolic reprogramming modulates the biological functions of many immune and non-immune cells, and affects immune response types and intensities. Adenosine and indoleamine 2,3-dioxygenase (IDO) are known immunosuppressors, and adenosine is a hypoxia-associated product. We investigated the impact of hypoxia on IDO production in dendritic cells (DCs). We found that hypoxia (1% O2 ) enhances IDO production in DCs, and this increase was dependent on the adenosine A3 receptor (A3R), but not A2aR or A2bR...
February 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29538091/lymphoid-aggregates-in-desmoplastic-melanoma-have-features-of-tertiary-lymphoid-structures
#10
Anne M Stowman, Alexandra W Hickman, Ileana S Mauldin, Adela Mahmutovic, Alejandro A Gru, Craig L Slingluff
Desmoplastic melanomas (DM) have unique and challenging clinical presentations and histomorphology. A characteristic feature is the presence of scattered lymphoid aggregates. However, the nature of these aggregates is not defined. We hypothesized that they may be tertiary lymphoid structures (TLS), and may be associated with programmed death ligand 1 (PD-L1) expression. We searched our tissue database for 'pure' DMs and for scars as control tissues, collected clinical information, and reviewed H&E histology...
March 13, 2018: Melanoma Research
https://www.readbyqxmd.com/read/29531070/cd96-expression-determines-the-inflammatory-potential-of-il-9-producing-th9-cells
#11
Katarina Stanko, Christina Iwert, Christine Appelt, Katrin Vogt, Julia Schumann, Franziska Janina Strunk, Stefanie Ahrlich, Stephan Schlickeiser, Chiara Romagnani, Karsten Jürchott, Christian Meisel, Gerald Willimsky, Anja A Kühl, Birgit Sawitzki
Recent findings demonstrated proinflammatory functions of interleukin (IL)-9-producing T helper type (Th) 9 cells in the pathogenesis of intestinal bowel diseases (IBDs). However, also antiinflammatory properties have been ascribed to Th9 cells, pointing to a functional heterogeneity. To dissect the specific expression pattern and, especially, diversity of murine antigen-specific Th9 cells, we applied single cell transcription profiling. Th9 cells displayed reduced expression of typical activation markers, such as Cd40 ligand and Cd96 , whereas expression of Cd25 and Cd83 was increased compared with other Th subsets...
March 12, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29525600/an-autologous-tumor-vaccine-for-cll
#12
Fang Zhu, Ismat Khatri, David Spaner, Reginald M Gorczynski
Chronic Lymphocytic Leukemia B cells (CLL) are malignant cells which retain at least some functions of normal B cells. Paramount amongst the latter is that when such cells are appropriately stimulated, they are able to present antigens, including any potential tumor antigens, making them excellent choices as a candidate tumor vaccine. We show that following stimulation of CLL cells with Phorbol myristic acetate, IL-2, the TLR7 agonist imiquimod (P2I) and ionomycin (P2Iio), markedly increased expression of CD54 and CD83 was seen, indicative of B cell activation and a transition to antigen-presenting cells...
March 2, 2018: Leukemia Research
https://www.readbyqxmd.com/read/29501009/in-vitro-maturation-of-monocyte-derived-dendritic-cells-results-in-two-populations-of-cells-with-different-surface-marker-expression-independently-of-applied-concentration-of-interleukin-4
#13
Paweł P Wołkow, Anna Gębska, Ryszard Korbut
Dendritic cells (DCs) play a crucial role in the development of adaptive immune response. Monocyte-derived dendritic cells (MDDCs) are generated in vitro to study DC biology and for use in immunotherapy. However, procedures to generate MDDCs vary and an impact this may have on their final phenotype is insufficiently studied. Monocytes isolated from healthy blood donors were cultured for 7 days with granulocyte-macrophage colony stimulating factor (50 ng/mL) and low (500 IU/mL, L-IL4) or high (1000 IU/mL, H-IL4) interleukin 4 (IL4), to obtain immature DCs and for the following 2 days with addition of soluble CD40 ligand (500 ng/mL) and prostaglandin E2 (1 μg/mL) to obtain mature DCs...
February 28, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29493822/detailed-analysis-of-inflammatory-cell-infiltration-and-the-prognostic-impact-on-nasopharyngeal-carcinoma
#14
Juan Lu, Xiao-Mei Chen, Hao-Ran Huang, Fei-Peng Zhao, Fan Wang, Xiong Liu, Xiang-Ping Li
BACKGROUND: One of the most striking characteristics of nasopharyngeal carcinoma (NPC) is the presence of a very abundant immune cells infiltrate containing mainly T-lymphocytes. The purpose of this study was to present our analysis providing a comprehensive characterization of antitumor inflammatory response in NPC. METHODS: The densities of 9 types of inflammatory cells were assessed in 197 patients with NPC, including CD3 + T-lymphocytes, CD8 + cytotoxic T-lymphocytes, CD20 + B-lymphocytes, CD56 + natural killer (NK) cells, FOXP3 + regulatory T-lymphocytes, CD1a + immature dendritic cells, CD83 + mature dendritic cells, neutrophil elastase + neutrophils, and tryptase + mast cells...
March 1, 2018: Head & Neck
https://www.readbyqxmd.com/read/29476080/profiling-atlantic-salmon-b-cell-populations-cpg-mediated-tlr-ligation-enhances-igm-secretion-and-modulates-immune-gene-expression
#15
Shiferaw Jenberie, Hanna L Thim, J Oriol Sunyer, Karsten Skjødt, Ingvill Jensen, Jorunn B Jørgensen
While TLR-activated pathways are key regulators of B cell responses in mammals, their impact on teleost B cells are scarcely addressed. Here, the potential of Atlantic salmon B cells to respond to TLR ligands was shown by demonstrating a constitutive expression of nucleic-acid sensing TLRs in magnetic sorted IgM+ cells. Of the two receptors recognizing CpG in teleosts, tlr9 was the dominating receptor with over ten-fold higher expression than tlr21. Upon CpG-stimulation, IgM secretion increased for head kidney (HK) and splenic IgM+ cells, while blood B cells were marginally affected...
February 23, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29468363/the-bcr-abl-inhibitor-nilotinib-influences-phenotype-and-function-of-monocyte-derived-human-dendritic-cells
#16
Daniela Dörfel, Christian J Lechner, Simone Joas, Tanja Funk, Michael Gutknecht, Julia Salih, Julian Geiger, Korbinian N Kropp, Stefanie Maurer, Martin R Müller, Hans-Georg Kopp, Helmut R Salih, Frank Grünebach, Susanne M Rittig
In chronic myeloid leukemia (CML), the translocation t(9;22) results in the fusion protein BCR-ABL (breakpoint cluster region-abelson murine leukemia), a tyrosine kinase mediating oncogenic signaling which is successfully targeted by treatment with BCR-ABL inhibitors like imatinib. However, BCR-ABL inhibitors may also affect antitumor immunity. For instance, it was reported that imatinib impairs the function of dendritic cells (DCs) that play a central role in initiating and sustaining T cell responses. Meanwhile, second generation BCR-ABL inhibitors like nilotinib, which inhibits BCR-ABL with enhanced potency have become standard of treatment, at least in patients with BCR-ABL kinase domain mutations...
February 21, 2018: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/29434934/effects-of-disodium-cantharidinate-on-dendritic-cells-of-patients-with-bladder-carcinoma
#17
Guang-Hui Zang, Rui Li, Rong-Sheng Zhou, Lin Hao, Hou-Guang He, Wen-Da Zhang, Yang Dong, Cong-Hui Han
The present study explored the effects of disodium cantharidinate (DC) on the peripheral blood-derived dendritic cells of patients with bladder carcinoma. The peripheral blood mononuclear cells from the 15 cases of urinary bladder carcinoma of middle and advanced stage were separated, and dendritic cells were prepared. The morphological changes of dendritic cells were observed. Flow cytometry was used to detect the expression levels of CD1a and CD83 on dendritic cell surface. MTT assay was utilized to measure the proliferation ability of allogeneic lymphocyte stimulated by DC...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29416536/trichinella-spiralis-excretory-secretory-products-induce-tolerogenic-properties-in-human-dendritic-cells-via-toll-like-receptors-2-and-4
#18
Nataša Ilic, Alisa Gruden-Movsesijan, Jelena Cvetkovic, Sergej Tomic, Dragana Bozidar Vucevic, Carmen Aranzamendi, Miodrag Colic, Elena Pinelli, Ljiljana Sofronic-Milosavljevic
Trichinella spiralis, as well as its muscle larvae excretory-secretory products (ES L1), given either alone or via dendritic cells (DCs), induce a tolerogenic immune microenvironment in inbred rodents and successfully ameliorate experimental autoimmune encephalomyelitis. ES L1 directs the immunological balance away from T helper (Th)1, toward Th2 and regulatory responses by modulating DCs phenotype. The ultimate goal of our work is to find out if it is possible to translate knowledge obtained in animal model to humans and to generate human tolerogenic DCs suitable for therapy of autoimmune diseases through stimulation with ES L1...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29414400/primary-cutaneous-histiocytic-sarcoma-a-report-of-five-cases-with-primary-cutaneous-involvement-and-review-of-the-literature
#19
Cynthia M Magro, Najiyah Kazi, Aimee E Sisinger
INTRODUCTION: Histiocytic sarcoma is an extremely rare hematologic malignancy of histiocytic origin. Five cases of primary cutaneous histiocytic sarcoma are presented. MATERIALS AND METHODS: Cases of primary cutaneous histiocytic sarcoma were identified using a natural language search from the dermatopathology data base of Cornell University. RESULTS: There was a male predominance (4 males and 1 female) ranging in age from 33years to 92years (mean age of 73years); all presented with a solitary nodule which involved the head and neck area in four and thigh in one...
February 2018: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29388277/promoter-polymorphisms-in-tgf-%C3%A2-1-and-il-10-genes-influence-tumor-dendritic-cells-infiltration-development-and-prognosis-of-colorectal-cancer
#20
Maya Gulubova, Elina Aleksandrova, Tatyana Vlaykova
INTRODUCTION: Anti-inflammatory cytokines such as interleukine-10 (IL-10) and the transforming growth factor beta-1 (TGF-®1) have a complex role in the development of colorectal cancer (CRC). Dendritic cells (DCs) are the cellular component of the inflammatory microenvironment in the tumor and infiltration of tumors by DCs is associated with better prognosis and fewer metastases. AIMS: In the current study we aimed to explore the role of two single nucleotide polymorphisms (SNPs) in the promoter regions of TGFB1 and IL10 genes and their associations with infiltrating DCs in CRC...
January 31, 2018: Journal of Gene Medicine
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