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JOURNAL ARTICLE
Maha T Alsharif, Elham Alsahafi
(1) Background: Human papillomavirus (HPV) infection is significantly associated with oropharyngeal squamous cell carcinoma (HPV-OPSCC), which is one of the fastest-growing cancer incidences globally. Dental practitioners play a crucial role in the primary and secondary prevention of HPV-OPSCC. There is little known about dental students' awareness regarding HPV-OPSCC and HPV vaccination, as well as their intention to promote 'primordial prevention' among their patients. HPV vaccine, and the extent of their professional responsibilities...
April 26, 2024: Healthcare (Basel, Switzerland)
#2
JOURNAL ARTICLE
Teshale Fikadu, Zeleke Gebru, Getachew Abebe, Selamnesh Tesfaye, Eshetu Andarge Zeleke
BACKGROUND: Even though childhood vaccination is a common and cost-effective public health intervention in preventing and reducing childhood disease and death, significant numbers of children do not complete vaccination within the first year of life. Studies indicated that user satisfaction influences service utilization and used as a key indicator of quality care. However, evidence on the level of mothers' satisfaction with immunization service are limited in urban and accessible places and not well investigated among remote and pastoral communities...
May 9, 2024: BMC Women's Health
#3
JOURNAL ARTICLE
Abdi Birhanu, Michael Shawel Lemma, Biruk Habtamu, Nahom Wondwossen Worku, Monas Kitessa, Shambel Nigusie, Galana Mamo Ayana, Yehenaw Tenaw, Selamawit Sete, Bedasa Taye Merga, Ibsa Mussa
BACKGROUND: The occurrence of long-lasting comorbidities makes cancer management and treatment challenging because of their overlapping poor prognosis. However, there are no data that show the burden of these chronic cases in patients with cancer in Ethiopia. Therefore, this study aimed to assess the burden of and the factors associated with chronic disease comorbidity among cancer patients in the eastern part of Ethiopia. MATERIAL AND METHODS: A cross-sectional study was conducted on 422 patients with cancer admitted to the only cancer treatment center in eastern Ethiopia...
2024: Frontiers in Oncology
#4
JOURNAL ARTICLE
Corrado Pelaia, Eleonora Zannoni, Giovanni Paoletti, Valentina Marzio, Enrico Heffler, Alejandra Carrón-Herrero
PURPOSE OF REVIEW: The aim of this study was Describe the latest evidence related to the concept of clinical remission in patients with severe asthma, focusing on the lights and shadows of this concept. RECENT FINDINGS: The idea of clinical remission in severe asthma patients brings about a significant shift in the way asthma is treated and managed. Although there has yet to be unanimous agreement among various scientific societies on the precise definition, this concept can be extremely useful in advancing the treatment of the disease...
May 1, 2024: Current Opinion in Allergy and Clinical Immunology
#5
JOURNAL ARTICLE
Mounia Lahfa, Philippe Barthe, Karine de Guillen, Stella Cesari, Mouna Raji, Thomas Kroj, Marie Le Naour-Vernet, François Hoh, Pierre Gladieux, Christian Roumestand, Jérôme Gracy, Nathalie Declerck, André Padilla
Magnaporthe AVRs and ToxB-like (MAX) effectors constitute a family of secreted virulence proteins in the fungus Pyricularia oryzae (syn. Magnaporthe oryzae), which causes blast disease on numerous cereals and grasses. In spite of high sequence divergence, MAX effectors share a common fold characterized by a ß-sandwich core stabilized by a conserved disulfide bond. In this study, we investigated the structural landscape and diversity within the MAX effector repertoire of P. oryzae. Combining experimental protein structure determination and in silico structure modeling we validated the presence of the conserved MAX effector core domain in 77 out of 94 groups of orthologs (OG) identified in a previous population genomic study...
May 6, 2024: PLoS Pathogens
#6
JOURNAL ARTICLE
Johanna Teräsjärvi, Leena Kainulainen, Ville Peltola, Jussi Mertsola, Antti Hakanen, Qiushui He
Toll-like receptors (TLRs) play an important role in innate immunity. Previous studies have shown that single nucleotide polymorphisms (SNPs) in the genes coding for these innate immune molecules can affect susceptibility to and the outcome of certain diseases. The aim of the present study was to examine the clinical relevance of well-studied TLR1-4 SNPs in individuals who are prone to infections. Four functional SNPs, TLR1 rs5743618 (1805C > A, Ser602Ile), TLR2 rs5743708 (2258G > A, Arg753Gln), TLR3 rs3775291 (1234C > T, Leu412Phe) and TLR4 rs4986790 (896A > G, Asp299Gly), were analysed in 155 patients with recurrent respiratory infections (n = 84), severe infections (n = 15) or common variable immunodeficiency (n = 56), and in 262 healthy controls, using the High Resolution Melting Analysis method...
May 5, 2024: International Journal of Immunogenetics
#7
REVIEW
Richard E Frye, Nicole Rincon, Patrick J McCarty, Danielle Brister, Adrienne C Scheck, Daniel A Rossignol
Autism spectrum disorder (ASD) is a neurodevelopmental disorder affecting 1 in 36 children and is associated with physiological abnormalities, most notably mitochondrial dysfunction, at least in a subset of individuals. This systematic review and meta-analysis discovered 204 relevant articles which evaluated biomarkers of mitochondrial dysfunction in ASD individuals. Significant elevations (all p < 0.01) in the prevalence of lactate (17%), pyruvate (41%), alanine (15%) and creatine kinase (9%) were found in ASD...
May 2, 2024: Neurobiology of Disease
#8
JOURNAL ARTICLE
Hanmei Zhang, Meiwen Yu, Guirong Liang, Suo Li, Chenjing Zhao, Ke Jing, Suying Feng
BACKGROUND: The manifestations of bullous pemphigoid (BP) and herpes simplex virus (HSV) infection are similar in oral mucosa, and the laboratory detection of HSV has some limitations, making it difficult to identify the HSV infection in oral lesions of BP. In addition, the treatments for BP and HSV infection have contradictory aspects. Thus, it is important to identify the HSV infection in BP patients in time. OBJECTIVE: To identify the prevalence and clinical markers of HSV infection in oral lesions of BP...
2024: Frontiers in Immunology
#9
MULTICENTER STUDY
Leanne P M van Leeuwen, Marloes Grobben, Corine H GeurtsvanKessel, Pauline M Ellerbroek, Godelieve J de Bree, Judith Potjewijd, Abraham Rutgers, Hetty Jolink, Frank L van de Veerdonk, Marit J van Gils, Rory D de Vries, Virgil A S H Dalm
PURPOSE: Previous studies have demonstrated that the majority of patients with an inborn error of immunity (IEI) develop a spike (S)-specific IgG antibody and T-cell response after two doses of the mRNA-1273 COVID-19 vaccine, but little is known about the response to a booster vaccination. We studied the immune responses 8 weeks after booster vaccination with mRNA-based COVID-19 vaccines in 171 IEI patients. Moreover, we evaluated the clinical outcomes in these patients one year after the start of the Dutch COVID-19 vaccination campaign...
2024: Frontiers in Immunology
#10
JOURNAL ARTICLE
Amani Y Alhalwani, Shatha Jambi, Anwar Borai, Muhammad Anwar Khan, Hashem Almarzouki, Mohieldin Elsayid, Abdullah Fahad Aseri, Nada O Taher, Ali Alghamdi, Abdulwahab Alshehri
BACKGROUND: The inflammation plays a role in the pathophysiology of type-2 diabetes progression, and the mechanism remains unclear. The systemic immune-inflammation index (SII) is a novel inflammatory marker for type 2 diabetes patients and integrates multiple indicators in complete blood counts and routine blood tests. AIM: Since there is no international diagnostic standard for dry eye disease (DED), this study uses low-cost inflammatory blood biomarkers to investigate the correlation between SII and DM2-DED and determine the diagnosis indices of other biomarkers in DM2-DED...
May 2024: Health Science Reports
#11
JOURNAL ARTICLE
V Šimka, M Špačková
AIM: Pinworm infection (known as enterobiasis or oxyuriasis) is one of the most common parasitic diseases globally and in the Czech Republic (CZ). The aim of this study is to analyse the available epidemiological data on the incidence of enterobiasis in the CZ from 2018-2022. METHODS: A descriptive analysis was done of enterobiasis (ICD-10 code B80) data reported to the electronic Infectious Disease Information System in the CZ from 2018 to 2022. Data processing and analysis were conducted using MS Excel 2016...
2024: Epidemiologie, Mikrobiologie, Imunologie
#12
JOURNAL ARTICLE
Juan Francisco Gutiérrez-Bautista, Irene Díaz-Alberola, María Tarriño, María Aguilera, Fernando Cobo, Juan Antonio Reguera, Javier Rodríguez-Granger, Joaquín Mendoza, Miguel Ángel López-Nevot, Antonio Sampedro
The COVID-19 pandemic highlighted the importance of effective vaccination strategies in controlling the spread of infectious diseases. SARS-CoV-2 vaccine has demonstrated high efficacy in preventing COVID-19 infection in the general population. However, the efficacy of this vaccine in patients with predominantly antibody deficiencies, such as common variable immunodeficiency (CVID) and X-linked agammaglobulinemia (XLA), should be closely monitored. CVID and XLA are rare genetic disorders that impair the immune system's ability to produce antibodies, which are crucial for fighting infections...
May 2, 2024: Clinical and Experimental Immunology
#13
JOURNAL ARTICLE
Carole Le Coz, Melissa Trofa, Dorothy L Butler, Samuel Yoon, Tian Tian, Whitney Reid, Emylette Cruz Cabrera, Ainsley V C Knox, Caroline Khanna, Kathleen E Sullivan, Jennifer Heimall, Patricia Takach, Olajumoke O Fadugba, Monica Lawrence, Soma Jyonouchi, Hakon Hakonarson, Andrew D Wells, Steven Handler, Karen B Zur, Vinodh Pillai, Jeffrey C Gildersleeve, Neil Romberg
BACKGROUND: Autoantibody-mediated cytopenias (AICs) regularly occur in profoundly IgG-deficient common variable immunodeficiency (CVID) patients. The isotypes, antigenic targets, and origin(s) of their disease-causing autoantibodies are unclear. OBJECTIVE: To determine reactivity, clonality and provenance of AIC-associated IgM autoantibodies in CVID patients. METHODS: We utilized glycan arrays, patient erythrocytes, and platelets to determine targets of CVID IgM autoantibodies...
April 29, 2024: Journal of Allergy and Clinical Immunology
#14
JOURNAL ARTICLE
Ruth Johnson, Alexis V Stephens, Rachel Mester, Sergey Knyazev, Lisa A Kohn, Malika K Freund, Leroy Bondhus, Brian L Hill, Tommer Schwarz, Noah Zaitlen, Valerie A Arboleda, Lisa A Bastarache, Bogdan Pasaniuc, Manish J Butte
Human inborn errors of immunity include rare disorders entailing functional and quantitative antibody deficiencies due to impaired B cells called the common variable immunodeficiency (CVID) phenotype. Patients with CVID face delayed diagnoses and treatments for 5 to 15 years after symptom onset because the disorders are rare (prevalence of ~1/25,000), and there is extensive heterogeneity in CVID phenotypes, ranging from infections to autoimmunity to inflammatory conditions, overlapping with other more common disorders...
May 2024: Science Translational Medicine
#15
REVIEW
Gabriela Assunção Goebel, Cíntia Silva de Assis, Luciana Araújo Oliveira Cunha, Fernanda Gontijo Minafra, Jorge Andrade Pinto
This study aims to perform an extensive review of the literature that evaluates various factors that affect the survival rates of patients with severe combined immunodeficiency (SCID) after hematopoietic stem cell transplantation (HSCT) in developed and developing countries. An extensive search of the literature was made in four different databases (PubMed, Embase, Scopus, and Web of Science). The search was carried out in December 2022 and updated in July 2023, and the terms such as "hematopoietic stem cell transplantation," "bone marrow transplant," "mortality," "opportunistic infections," and "survival" associated with "severe combined immunodeficiency" were sought based on the MeSH terms...
April 30, 2024: Clinical Reviews in Allergy & Immunology
#16
JOURNAL ARTICLE
Jingping Liu, Yujia Sun, Chunxin Tian, Dong Qin, Lanying Gao
Objective Allergic asthma (AA) is common in children. Excess copper is observed in AA patients. It is currently unclear whether copper imbalance can cause cuproptosis in pediatric AA. Methods The datasets about pediatric AA (GSE40732 and GSE40888) were obtained from Gene Expression Omnibus (GEO) database. The expression of cuproptosis-related genes (CRGs) and immune cell infiltration in pediatric AA samples were analyzed. Single-cell RNA sequencing (scRNA-seq) data (GSE193816) were used to evaluate the expression patterns of CRGs in AA...
April 30, 2024: Journal of Asthma
#17
JOURNAL ARTICLE
José Alcides Almeida de Arruda, Mariana Villarroel-Dorrego, Clara Herrera Freire, Ignacio Molina-Ávila, Juan Martin Pimentel-Solá, Gerardo Gilligan, Eduardo Piemonte, René Panico, Juan Cruz Romero Panico, Saray Aranda-Romo, Francisco Javier Tejeda-Nava, Mônica Simões Israel, John Lennon Silva Cunha, Vanessa Alves de Medeiros, Cassiano Francisco Weege Nonaka, Pollianna Muniz Alves, Israel Leal Cavalcante, José Victor Lemos Ventura, Fernanda Silva de Lima, Victor Zanetti Drumond, Lucas Guimarães Abreu, Tarcília Aparecida Silva, Felipe Paiva Fonseca, Ricardo Alves Mesquita, René Martínez-Flores, Karina Cordero-Torres, Richard Ahumada-Ossandón, Jorge Guzmán, Raiza Toro, José Cândido Caldeira Xavier-Júnior, Sebastião Silvério Sousa-Neto, Diego Antônio Costa Arantes, Elismauro Francisco Mendonça, Victor de Mello Palma, Márcia Gaiger de Oliveira, Fernanda Visioli, Karem L Ortega, Jefferson R Tenório, Bruno Augusto Benevenuto de Andrade
BACKGROUND: Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease that may affect the oral mucosa. The variable spectrum of oral lesions observed in SLE can pose challenges in diagnosis, particularly when the lesions occur in isolation. The aim of this study was to describe the oral lesions occurring in patients with SLE from Latin America. METHODS: This collaborative record-based study involving 11 oral and maxillofacial pathology and medicine services across Venezuela, Argentina, Chile, Brazil, and Mexico describes the clinicopathological profile of SLE-related oral lesions...
April 30, 2024: Lupus
#18
JOURNAL ARTICLE
Maria V Dimou, Paraskevi Xepapadaki, John Lakoumentas, Leonardos Mageiros, Xenophon Aggelidis, Maria Antonopoulou, Petros Bakakos, Sophia Βotskariova, Konstantinos Chliveros, Spyridon Chrysoulakis, Dionysios Dimas, Nikolaos Douladiris, Mina Gaga, Christos Grigoreas, Lampros Kalogiros, Michael Katotomichelakis, Evangelia Kompoti, Jannis Constantinidis, Zoi Koutsogianni, Stelios Loukides, Michael Makris, Emmanouil Manousakis, Pavlos Marangoudakis, Maria Marmara, Nikolaos Mikos, Paraskevi Mitsakou, Dimitrios Mitsias, Aris Pagalos, Vasilios Papanikolaou, Ioannis Paraskevopoulos, Constantinos Pitsios, Fotis Psarros, Nikoletta Rovina, Konstantinos Samitas, Evaggelia Stefanaki, Mina Vallianatou, Dimitrios Vourdas, Ioanna Tsiligianni, Jean Bousquet, Nikolaos G Papadopoulos
BACKGROUND: Allergic rhinitis (AR) is a common respiratory disease encompassing a variety of phenotypes. Patients can be sensitized to one or more allergens. There are indications that polysensitization is associated with more severe disease. However, the extent to which the level of sensitization is associated to clinical disease variability, underlying the distinct nature of AR from AR+ conjunctivitis or AR+ asthma, is not known. OBJECTIVE: The aim of this study was to evaluate phenotypical differences between mono- and poly-sensitized patients with AR and to quantify their symptomatic variability...
April 26, 2024: Annals of Allergy, Asthma & Immunology
#19
JOURNAL ARTICLE
Jennifer Y Li, Maria S Cortina, Mark A Greiner, Anthony N Kuo, Darby D Miller, Roni M Shtein, Peter B Veldman, Jia Yin, Stephen J Kim, Joanne F Shen
PURPOSE: To review the published literature on the safety and outcomes of keratolimbal allograft (KLAL) transplantation and living-related conjunctival limbal allograft (lr-CLAL) transplantation for bilateral severe/total limbal stem cell deficiency (LSCD). METHODS: Literature searches were last conducted in the PubMed database in February 2023 and were limited to the English language. They yielded 523 citations; 76 were reviewed in full text, and 21 met the inclusion criteria...
April 27, 2024: Ophthalmology
#20
JOURNAL ARTICLE
Muhammed Salah Uddin, Angelo Kaldis, Rima Menassa, José Ortiz Guluarte, Daniel R Barreda, Le Luo Guan, Trevor W Alexander
BACKGROUND: Mannheimia haemolytica is a bovine respiratory pathogen commonly associated with bacterial bronchopneumonia. Current vaccine strategies have shown variable efficacy in feedlot cattle, and therefore novel vaccines are needed. Bacillus subtilis spores have been investigated as a mucosal vaccine platform, due to their ability to bind and present antigens to the mucosa and act as an adjuvant. The aim of this study was to develop two spore-based mucosal vaccines targeting M. haemolytica and evaluate their immunogenicity in mice...
April 1, 2024: Vaccines
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