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https://www.readbyqxmd.com/read/29786922/finding-factors-that-predict-treatment-resistant-depression-results-of-a-cohort-study
#1
M Soledad Cepeda, Jenna Reps, Patrick Ryan
BACKGROUND: Treatment for depressive disorders often requires subsequent interventions. Patients who do not respond to antidepressants have treatment-resistant depression (TRD). Predicting who will develop TRD may help healthcare providers make more effective treatment decisions. We sought to identify factors that predict TRD in a real-world setting using claims databases. METHODS: A retrospective cohort study was conducted in a US claims database of adult subjects with newly diagnosed and treated depression with no mania, dementia, and psychosis...
May 22, 2018: Depression and Anxiety
https://www.readbyqxmd.com/read/29786087/a-comparison-of-23-gauge-and-20-gauge-vitrectomy-for-proliferative-sickle-cell-retinopathy-clinical-outcomes-and-surgical-management
#2
Jason Ho, Anna Grabowska, Marta Ugarte, Mahiul Mk Muqit
AIMS: To report anatomical and functional outcomes in patients with proliferative sickle retinopathy (PSR) who underwent 23-gauge (23G) and 20-gauge (20G) vitrectomy. METHODS: Retrospective consecutive case series of patients who underwent vitreoretinal intervention for complications of PSR between April 2009 and February 2015. Operations were performed at a tertiary referral centre, Moorfields Eye Hospital. Visual acuity and anatomical success rates were evaluated for PSR complicated by retinal detachment, tractional vitreous haemorrhage and macular hole...
May 22, 2018: Eye
https://www.readbyqxmd.com/read/29779809/identification-of-core-items-in-the-enhanced-recovery-pathway
#3
Marco Braga, Marco Scatizzi, Felice Borghi, Giancarlo Missana, Danilo Radrizzani, Marco Gemma
BACKGROUND & AIMS: The Enhanced Recovery After Surgery (ERAS) pathway represents an optimal approach in patients undergoing colorectal surgery but complexity in implementing its items could limit its application. The aim of this study is to identify possible core items within an ERAS pathway following elective colorectal resection. METHODS: This is a retrospective review of data prospectively collected between January 2014 and September 2015 by 14 Italian Hospitals in an electronic registry dedicated to an ERAS protocol...
June 2018: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29761488/psychological-therapies-for-treatment-resistant-depression-in-adults
#4
REVIEW
Sharea Ijaz, Philippa Davies, Catherine J Williams, David Kessler, Glyn Lewis, Nicola Wiles
BACKGROUND: Antidepressants are a first-line treatment for adults with moderate to severe major depression. However, many people prescribed antidepressants for depression don't respond fully to such medication, and little evidence is available to inform the most appropriate 'next step' treatment for such patients, who may be referred to as having treatment-resistant depression (TRD). National Institute for Health and Care Excellence (NICE) guidance suggests that the 'next step' for those who do not respond to antidepressants may include a change in the dose or type of antidepressant medication, the addition of another medication, or the start of psychotherapy...
May 14, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29739524/treatment-resistant-depression-the-importance-of-identifying-and-treating-co-occurring-personality-disorders
#5
REVIEW
Michael Young
Treatment-resistant depression (TRD) presents a significant burden to individuals and society, and comprehensive, individualized approaches are needed to address this complex clinical situation. Diagnostic reevaluation is indicated in cases of TRD to determine the numerous factors that could be playing a role in the treatment resistance. Factors to assess during the diagnostic reevaluation are discussed, including assessment for personality disorders, which are common contributors to treatment resistance and are often not adequately addressed...
June 2018: Psychiatric Clinics of North America
https://www.readbyqxmd.com/read/29730251/effects-of-prefrontal-theta-burst-stimulation-on-brain-function-in-treatment-resistant-depression-a-randomized-sham-controlled-neuroimaging-study
#6
Cheng-Ta Li, Mu-Hong Chen, Chi-Hung Juan, Ren-Shyan Liu, Wei-Chen Lin, Ya-Mei Bai, Tung-Ping Su
BACKGROUND: Theta-burst transcranial magnetic stimulation (TBS) can quickly modulate brain activity and can be used to treat treatment-resistant depression (TRD). Whole-brain analytical research has revealed that left high-frequency PFC rTMS modulates brain activity in anterior cingulate cortex (ACC) and the fronto-cingulo-temporal circuit. We aimed to investigate whether the prefrontal TBS's antidepressant mechanisms involve these regions. METHODS: We designed a randomized, double-blind, sham-controlled neuroimaging study to investigate different mechanisms of TBS [i...
April 23, 2018: Brain Stimulation
https://www.readbyqxmd.com/read/29727073/efficacy-safety-and-durability-of-repeated-ketamine-infusions-for-comorbid-posttraumatic-stress-disorder-and-treatment-resistant-depression
#7
C Sophia Albott, Kelvin O Lim, Miriam K Forbes, Christopher Erbes, Susanna J Tye, John G Grabowski, Paul Thuras, Tegan M Batres-Y-Carr, Joseph Wels, Paulo R Shiroma
OBJECTIVE: The present study examined the efficacy, safety, and durability of repeated ketamine infusions for the treatment of comorbid posttraumatic stress disorder (PTSD) and treatment-resistant depression (TRD) in a sample of veterans. METHODS: Individuals with comorbid DSM-5-defined PTSD and DSM-IV-defined major depressive disorder (N = 15) received 6 intravenous ketamine infusions (0.5 mg/kg) on a Monday-Wednesday-Friday schedule over a 12-day period from May 2015 to June 2016...
May 1, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29723763/behavioral-activation-therapy-during-transcranial-magnetic-stimulation-for-major-depressive-disorder
#8
Grace B Russo, Eric Tirrell, Andrew Busch, Linda L Carpenter
BACKGROUND: Behavioral Activation (BA) Therapy and Transcranial Magnetic Stimulation (TMS) have each been shown to be effective in the treatment of adult outpatients with major depressive disorder (MDD). Combining both treatments may produce synergistic antidepressant outcomes. METHODS: We developed a new protocol for incorporating a simplified version of BA during a standard 6-week course of TMS and it was pilot tested in 11 consecutively treated outpatients with treatment resistant depression (TRD)...
April 25, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29702650/effects-of-growth-rate-cell-size-motion-and-elemental-stoichiometry-on-nutrient-transport-kinetics
#9
Kevin J Flynn, David O F Skibinski, Christian Lindemann
Nutrient acquisition is a critical determinant for the competitive advantage for auto- and osmohetero- trophs alike. Nutrient limited growth is commonly described on a whole cell basis through reference to a maximum growth rate (Gmax) and a half-saturation constant (KG). This empirical application of a Michaelis-Menten like description ignores the multiple underlying feedbacks between physiology contributing to growth, cell size, elemental stoichiometry and cell motion. Here we explore these relationships with reference to the kinetics of the nutrient transporter protein, the transporter rate density at the cell surface (TRD; potential transport rate per unit plasma-membrane area), and diffusion gradients...
April 27, 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29701939/bilateral-repetitive-transcranial-magnetic-stimulation-decreases-suicidal-ideation-in-depression
#10
Cory R Weissman, Daniel M Blumberger, Patrick E Brown, Moshe Isserles, Tarek K Rajji, Jonathan Downar, Benoit H Mulsant, Paul B Fitzgerald, Zafiris J Daskalakis
OBJECTIVE: The purpose of this study was to evaluate the effects of repetitive transcranial magnetic stimulation (rTMS) on suicidal ideation in patients with treatment-resistant major depression (TRD) (patients who failed to clinically respond to at least 2 medication trials). METHODS: We pooled data from 2 published prospective randomized controlled trials of rTMS applied to the dorsolateral prefrontal cortex in patients with TRD. We compared the effect of bilateral, left unilateral, and sham rTMS on suicidal ideation as measured by the suicide item of the 17-item Hamilton Depression Rating Scale (HDRS) (N = 156)...
April 17, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29701454/comparative-analysis-of-aqueous-binders-for-high-energy-li-rich-nmc-as-lithium-ion-cathode-and-the-impact-of-adding-phosphoric-acid
#11
Arefeh Kazzazi, Dominic Bresser, Agnese Birrozzi, Jan von Zamory, Maral Hekmatfar, Stefano Passerini
Even though electrochemically inactive, the binding agent in lithium-ion electrodes contributes substantially to performance metrics like the achievable capacity, rate capability, and cycling stability. Herein, we present an in-depth comparative analysis of three different aqueous binding agents, allowing for the replacement of the toxic N-methyl-2-pyrrolidone (NMP) as processing solvent, for high-energy Li1.2Ni0.16Mn0.56Co0.08O2 (Li-rich NMC or LR-NMC) as potential next generation cathode material. The impact of the binding agents, sodium carboxymethyl cellulose (CMC), sodium alginate (ALG), and commercial TRD202A (TRD), and the related chemical reactions occurring during the electrode coating process on the electrode morphology and cycling performance is investigated...
April 27, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29692707/vagus-nerve-stimulation-vns-and-other-augmentation-strategies-for-therapy-resistant-depression-trd-review-of-the-evidence-and-clinical-advice-for-use
#12
REVIEW
Helge H O Müller, Sebastian Moeller, Caroline Lücke, Alexandra P Lam, Niclas Braun, Alexandra Philipsen
In addition to electroconvulsive therapy (ECT) and repetitive transcranial magnetic stimulation (rTMS), vagus nerve stimulation (VNS) is one of the approved neurostimulation tools for treatment of major depression. VNS is particularly used in therapy-resistant depression (TRD) and exhibits antidepressive and augmentative effects. In long-term treatment, up to two-thirds of patients respond. This mini-review provides a comprehensive overview of augmentation pharmacotherapy and neurostimulation-based treatment strategies, with a special focus on VNS in TRD, and provides practical clinical advice for how to select TRD patients for add-on neurostimulation treatment strategies...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29692350/the-evolution-of-polymorphic-hybrid-incompatibilities-in-house-mice
#13
Erica L Larson, Dan Vanderpool, Brice A J Sarver, Colin Callahan, Sara Keeble, Lorraine P Provencio, Michael D Kessler, Vanessa Stewart, Erin Nordquist, Matthew D Dean, Jeffrey M Good
Resolving the mechanistic and genetic bases of reproductive barriers between species is essential to understanding the evolutionary forces that shape speciation. Intrinsic hybrid incompatibilities are often treated as fixed between species, yet there can be considerable variation in the strength of reproductive isolation between populations. The extent and causes of this variation remain poorly understood in most systems. We investigated the genetic basis of variable hybrid male sterility (HMS) between two recently diverged subspecies of house mice, Mus musculus domesticus and M...
April 24, 2018: Genetics
https://www.readbyqxmd.com/read/29681284/alkylsilyl-speciation-and-direct-sample-preparation-of-plant-cannabinoids-prior-to-their-analysis-by-gc-ms
#14
Blanka Fodor, Imre Boldizsár, Ibolya Molnár-Perl
A literature criticism is given on methods currently using gas chromatography mass spectrometry (GC-MS) to determine plant cannabinoids (p-CBDs). In this study, trialkylsilylation of seven p-CBDs (including their transformation products formed in the drug user's body) was compared applying various alkylsilyl reagents1 and the mass fragmentation properties of the corresponding derivatives were characterized. Derivatization, mass fragmentation and quantitation related model investigations were optimized as a function of the reaction times and conditions...
August 27, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29673146/predictors-of-response-to-ketamine-in-treatment-resistant-major-depressive-disorder-and-bipolar-disorder
#15
Carola Rong, Caroline Park, Joshua D Rosenblat, Mehala Subramaniapillai, Hannah Zuckerman, Dominika Fus, Yena L Lee, Zihang Pan, Elisa Brietzke, Rodrigo B Mansur, Danielle S Cha, Leanna M W Lui, Roger S McIntyre
OBJECTIVES: Extant evidence indicates that ketamine exerts rapid antidepressant effects in treatment-resistant depressive (TRD) symptoms as a part of major depressive disorder (MDD) and bipolar disorder (BD). The identification of depressed sub-populations that are more likely to benefit from ketamine treatment remains a priority. In keeping with this view, the present narrative review aims to identify the pretreatment predictors of response to ketamine in TRD as part of MDD and BD. METHOD: Electronic search engines PubMed/MEDLINE, ClinicalTrials...
April 17, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29665520/treatment-resistant-depression-and-suicidality
#16
REVIEW
Isidoor O Bergfeld, Mariska Mantione, Martijn Figee, P Richard Schuurman, Anja Lok, Damiaan Denys
BACKGROUND: Thirty percent of patients with treatment-resistant depression (TRD) attempt suicide at least once during their lifetime. However, it is unclear what the attempted and completed suicide incidences are in TRD patients after initiating a treatment, and whether specific treatments increase or decrease these incidences. METHODS: We searched PubMed systematically for studies of depressed patients who failed at least two antidepressant therapies and were followed for at least three months after initiating a treatment...
April 3, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29660639/elevated-tumor-necrosis-factor-alpha-receptor-subtype-1-and-the-association-with-abnormal-brain-function-in-treatment-resistant-depression
#17
Mao-Hsuan Huang, Mu-Hong Chen, Pei-Chi Tu, Ya Mei Bai, Tung-Ping Su, Bang-Hung Yang, Ren-Shyan Liu, Cheng-Ta Li
BACKGROUND: Major depressive disorder (MDD) patients have shown elevated plasma levels of pro-inflammatory biomarkers compared to healthy controls. We hypothesized increased serum tumor necrosis factor-alpha receptor subtype 1 (TNF-α R1) is more associated with impaired brain function in patients with treatment-resistant depression (TRD) than those without TRD. METHODS: 34 MDD patients and 34 healthy subjects were recruited and we separated MDD patients to TRD group (n = 20) and non-TRD (n = 14) group...
April 6, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29642877/standardisation-framework-for-the-maudsley-staging-method-for-treatment-resistance-in-depression
#18
Abebaw Fekadu, Jacek G Donocik, Anthony J Cleare
BACKGROUND: Treatment-resistant depression (TRD) is a serious and relatively common clinical condition. Lack of consensus on defining and staging TRD remains one of the main barriers to understanding TRD and approaches to intervention. The Maudsley Staging Method (MSM) is the first multidimensional model developed to define and stage treatment-resistance in "unipolar depression". The model is being used increasingly in treatment and epidemiological studies of TRD and has the potential to support consensus...
April 11, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29621905/pharmacodynamic-and-pharmacokinetic-evaluation-of-buprenorphine-samidorphan-for-the-treatment-of-major-depressive-disorder
#19
Renee-Marie Ragguett, Carola Rong, Joshua D Rosenblat, Roger C Ho, Roger S McIntyre
Treatment resistant depression (TRD) represents approximately 20% of all individuals receiving care for major depressive disorder. The opioidergic system is identified as a novel target which hitherto has not been sufficiently investigated in adults with TRD. The combination product buprenorphine + samidorphan is an opioid modulatory agent which has demonstrated replicated evidence of efficacy in TRD without abuse liability. Areas covered: Databases Pubmed, Google Scholar and clinicaltrials.gov were searched from inception through December 2017 for clinical trial information, pharmacokinetics, and pharmacodynamics of buprenorphine + samidorphan...
April 6, 2018: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/29616028/human-%C3%AE-%C3%AE-t-cell-receptor-repertoires-in-peripheral-blood-remain-stable-despite-clearance-of-persistent-hepatitis-c-virus-infection-by-direct-acting-antiviral-drug-therapy
#20
Sarina Ravens, Julia Hengst, Verena Schlapphoff, Katja Deterding, Akshay Dhingra, Christian Schultze-Florey, Christian Koenecke, Markus Cornberg, Heiner Wedemeyer, Immo Prinz
Human γδ T cells can contribute to clearance of hepatitis C virus (HCV) infection but also mediate liver inflammation. This study aimed to understand the clonal distribution of γδ T cells in peripheral blood of chronic HCV patients and following HCV clearance by interferon-free direct-acting antiviral drug therapies. To this end, γδ T cell receptor (TCR) repertoires were monitored by mRNA-based next-generation sequencing. While the percentage of Vγ9+ T cells was higher in patients with elevated liver enzymes and a few expanded Vδ3 clones could be identified in peripheral blood of 23 HCV-infected non-cirrhotic patients, overall clonality and complexity of γδ TCR repertoires were largely comparable to those of matched healthy donors...
2018: Frontiers in Immunology
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