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https://www.readbyqxmd.com/read/28092469/investigational-drugs-in-recent-clinical-trials-for-treatment-resistant-depression
#1
Ricardo P Garay, Carlos A Zarate, Thomas Charpeaud, Leslie Citrome, Christoph U Correll, Ahcène Hameg, Pierre-Michel Llorca
The authors describe the medications for treatment-resistant depression (TRD) in phase II/III of clinical development in the EU and US and provide an opinion on how current treatment can be improved in the near future. Areas covered: Sixty-two trials were identified in US and EU clinical trial registries that included six investigational compounds in recent phase III development and 12 others in recent phase II clinical trials. Glutamatergic agents have been the focus of many studies. A single intravenous dose of the glutamatergic modulator ketamine produces a robust and rapid antidepressant effect in persons with TRD; this effect continues to remain significant for 1 week...
January 16, 2017: Expert Review of Neurotherapeutics
https://www.readbyqxmd.com/read/28068461/a-new-prediction-model-for-evaluating-treatment-resistant-depression
#2
Alexander Kautzky, Pia Baldinger-Melich, Georg S Kranz, Thomas Vanicek, Daniel Souery, Stuart Montgomery, Julien Mendlewicz, Joseph Zohar, Alessandro Serretti, Rupert Lanzenberger, Siegfried Kasper
OBJECTIVE: Despite a broad arsenal of antidepressants, about a third of patients suffering from major depressive disorder (MDD) do not respond sufficiently to adequate treatment. Using the data pool of the Group for the Study of Resistant Depression and machine learning, we intended to draw new insights featuring 48 clinical, sociodemographic, and psychosocial predictors for treatment outcome. METHOD: Patients were enrolled starting from January 2000 and diagnosed according to DSM-IV...
January 3, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28035869/comparative-efficacy-and-tolerability-of-pharmacological-and-somatic-interventions-in-adult-patients-with-treatment-resistant-depression-a-systematic-review-and-network-meta-analysis
#3
Katerina Papadimitropoulou, Carla Vossen, Andreas Karabis, Christina Donatti, Nicole Kubitz
OBJECTIVE: Major depressive disorder (MDD) affects about 10-15% of the general population in a lifetime. A considerable number of patients fail to achieve full symptom remission despite adequate treatment and are considered treatment-resistant (TRD). The current study compared the relative efficacy and tolerability of pharmacological and somatic TRD interventions by means of a Bayesian network meta-analysis. RESEARCH DESIGN AND METHODS: An electronic literature search of MEDLINE, MEDLINE In-Process, EMBASE, PsycInfo, EconLit and Cochrane Library databases for trial published between September 2003 and September 2014 was conducted...
December 30, 2016: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28012713/accurate-quantification-of-t-cells-by-measuring-loss-of-germline-t-cell-receptor-loci-with-generic-single-duplex-droplet-digital-pcr-assays
#4
Willem H Zoutman, Rogier J Nell, Mieke Versluis, Debby van Steenderen, Rajshri N Lalai, Jacoba J Out-Luiting, Mark J de Lange, Maarten H Vermeer, Anton W Langerak, Pieter A van der Velden
Quantifying T cells accurately in a variety of tissues of benign, inflammatory, or malignant origin can be of great importance in a variety of clinical applications. Flow cytometry and immunohistochemistry are considered to be gold-standard methods for T-cell quantification. However, these methods require fresh, frozen, or fixated cells and tissue of a certain quality. In addition, conventional and droplet digital PCR (ddPCR), whether followed by deep sequencing techniques, have been used to elucidate T-cell content by focusing on rearranged T-cell receptor (TCR) genes...
December 21, 2016: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/27994542/the-retrograde-connections-and-anatomical-segregation-of-the-g%C3%A3-ttingen-minipig-nucleus-accumbens
#5
Anders C Meidahl, Dariusz Orlowski, Jens C H Sørensen, Carsten R Bjarkam
Nucleus accumbens (NAcc) has been implicated in several psychiatric disorders such as treatment resistant depression (TRD), and obsessive-compulsive disorder (OCD), and has been an ongoing experimental target for deep brain stimulation (DBS) in both rats and humans. In order to translate basic scientific results from rodents to the human setting a large animal model is needed to thoroughly study the effect of such therapeutic interventions. The aim of the study was, accordingly, to describe the basic anatomy of the Göttingen minipig NAcc and its retrograde connections...
2016: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/27976600/clinical-improvements-following-bilateral-anterior-capsulotomy-in-treatment-resistant-depression
#6
L Subramanian, T Bracht, P Jenkins, S Choppin, D E J Linden, G Phillips, B A Simpson
BACKGROUND: The purpose of this study was to evaluate a programme of lesion surgery carried out on patients with treatment-resistant depression (TRD). METHOD: This was a retrospective study looking at clinical and psychometric data from 45 patients with TRD who had undergone bilateral stereotactic anterior capsulotomy surgery over a period of 15 years, with the approval of the Mental Health Act Commission (37 with unipolar depression and eight with bipolar disorder)...
December 15, 2016: Psychological Medicine
https://www.readbyqxmd.com/read/27934881/the-relationship-between-cortical-inhibition-and-electroconvulsive-therapy-in-the-treatment-of-major-depressive-disorder
#7
Daphne Voineskos, Andrea J Levinson, Yinming Sun, Mera S Barr, Faranak Farzan, Tarek K Rajji, Paul B Fitzgerald, Daniel M Blumberger, Zafiris J Daskalakis
Dysfunctional cortical inhibition (CI) is postulated as a key neurophysiological mechanism in major depressive disorder. Electroconvulsive therapy (ECT) is the treatment of choice for resistant depression and ECT has been associated with enhanced CI. The objective of this study was to evaluate the relationship between CI and ECT response in resistant depression. Twenty-five patients with treatment resistant depression underwent an acute course of ECT. CI was indexed by the cortical silent period (CSP) and short-interval cortical inhibition (SICI), through TMS-EMG...
December 9, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27928376/macular-ganglion-cell-layer-and-peripapillary-retinal-nerve-fibre-layer-thickness-in-patients-with-unilateral-posterior-cerebral-artery-ischaemic-lesion-an-optical-coherence-tomography-study
#8
Rita Anjos, Luisa Vieira, Livio Costa, André Vicente, Arnaldo Santos, Nuno Alves, Duarte Amado, Joana Ferreira, João Paulo Cunha
The purpose of this study is to evaluate the macular ganglion cell layer (GCL) and peripapillary retinal nerve fibre layer (RNFL) thickness in patients with unilateral posterior cerebral artery (PCA) ischaemic lesions using spectral-domain optical coherence tomography (SD-OCT). A prospective, case-control study of patients with unilateral PCA lesion was conducted in the neuro-ophthalmology clinic of Centro Hospitalar Lisboa Central. Macular and peripapillary SD-OCT scans were performed in both eyes of each patient...
February 2016: Neuro-ophthalmology
https://www.readbyqxmd.com/read/27922640/brain-network-reorganization-differs-in-response-to-stress-in-rats-genetically-predisposed-to-depression-and-stress-resilient-rats
#9
N Gass, R Becker, A J Schwarz, W Weber-Fahr, C Clemm von Hohenberg, B Vollmayr, A Sartorius
Treatment-resistant depression (TRD) remains a pressing clinical problem. Optimizing treatment requires better definition of the specificity of the involved brain circuits. The rat strain bred for negative cognitive state (NC) represents a genetic animal model of TRD with high face, construct and predictive validity. Vice versa, the positive cognitive state (PC) strain represents a stress-resilient phenotype. Although NC rats show depressive-like behavior, some symptoms such as anhedonia require an external trigger, i...
December 6, 2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27872807/identification-of-the-stria-medullaris-thalami-using-diffusion-tensor-imaging
#10
Ryan B Kochanski, Robert Dawe, Daniel B Eddelman, Mehmet Kocak, Sepehr Sani
BACKGROUND: Deep brain stimulation (DBS) via anatomical targeting of white matter tracts defined by diffusion tensor imaging (DTI) may be a useful tool in the treatment of pathologic neurophysiologic circuits implicated in certain disease states like treatment resistant depression (TRD). We sought to determine if DTI could be used to define the stria medullaris thalami (SM), the major afferent white matter pathway to the lateral habenula (LHb), a thalamic nucleus implicated in the pathophysiology of TRD...
2016: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27864716/single-incision-laparoscopic-surgery-increases-the-risk-of-unintentional-thermal-injury-from-the-monopolar-bovie-instrument-in-comparison-with-traditional-laparoscopy
#11
Nicole T Townsend, Edward L Jones, Doug Overbey, Bruce Dunne, Jennifer McHenry, Thomas N Robinson
BACKGROUND: Single-incision laparoscopic surgery (SILS) places multiple instruments in close, parallel proximity, an orientation that may have implications in the production of stray current from the monopolar "Bovie" instrument. The purpose of this study was to compare the energy transferred during SILS compared to traditional four-port laparoscopic surgery (TRD). METHOD: In a laparoscopic simulator, instruments were inserted via SILS or TRD setup. The monopolar generator delivered energy to a laparoscopic L-hook instrument for 5-s activations on 30-Watts coag mode...
November 18, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27810712/sleep-architecture-parameters-as-a-putative-biomarker-of-suicidal-ideation-in-treatment-resistant-depression
#12
Rebecca A Bernert, David A Luckenbaugh, Wallace C Duncan, Naomi G Iwata, Elizabeth D Ballard, Carlos A Zarate
BACKGROUND: Disturbed sleep may confer risk for suicidal behaviors. Polysomnographic (PSG) sleep parameters have not been systematically evaluated in association with suicidal ideation (SI) among individuals with treatment-resistant depression (TRD). METHODS: This secondary data analysis included 54 TRD individuals (N=30 with major depressive disorder (MDD) and N=24 with bipolar depression (BD)). PSG sleep parameters included Sleep Efficiency (SE), Total Sleep Time (TST), Wakefulness After Sleep Onset (WASO), REM percent/latency, and non-REM (NREM) Sleep Stages 1-4...
January 15, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27807990/usefulness-of-repetitive-transcranial-magnetic-stimulation-as-a-maintenance-treatment-in-patients-with-major-depression
#13
Frédéric Haesebaert, Rémi Moirand, Anne-Marie Schott-Pethelaz, Jérôme Brunelin, Emmanuel Poulet
OBJECTIVE: To investigate the clinical efficacy of repetitive Transcranial Magnetic Stimulation (rTMS), venlafaxine or a combination of both treatments as a maintenance treatment in patients with treatment-resistant depression (TRD). METHODS: In a 3-arm open-label study, 66 patients, including 45 remitters, who responded to rTMS (n = 25), venlafaxine (n = 22), or a combination of both treatments (n = 19) continued to receive the treatment that led to a response as a maintenance treatment over 12-month...
November 3, 2016: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/27796193/il6-174g%C3%A2-%C3%A2-c-genetic-polymorphism-influences-antidepressant-treatment-outcome
#14
Serafim Carvalho, Marlene Santos, Luís Lima, Jorge Mota-Pereira, Paulo Pimentel, Dulce Maia, Diana Correia, Sofia Gomes, Agostinho Cruz, Rui Medeiros
BACKGROUND: Major depressive disorder is a condition associated with dysregulated cytokine levels; among these, IL6. Furthermore, genetic variations within cytokine genes have been proposed to predict antidepressant treatment outcome. OBJECTIVES: This study aims to evaluate the role of IL6-174G > C and IL6R D358A A > C functional polymorphisms in antidepressant treatment phenotypes, specifically remission, relapse, and treatment resistant depression (TRD)...
October 31, 2016: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/27766398/enhanced-recovery-program-in-high-risk-patients-undergoing-colorectal-surgery-results-from-the-perioperative-italian-society-registry
#15
Marco Braga, Nicolò Pecorelli, Marco Scatizzi, Felice Borghi, Giancarlo Missana, Danilo Radrizzani
BACKGROUND: Enhanced recovery after surgery (ERAS) pathways represent the optimal approach for patients undergoing colorectal surgery. Elderly or low physical status patients have been often excluded from ERAS pathways because considered at high risk. The aim of this study is to assess the adherence to ERAS protocol and its impact on short-term postoperative outcome in patients with different surgical risk undergoing elective colorectal resection. METHODS: Prospectively collected data entered in an electronic Italian registry specifically designed for ERAS were reviewed...
October 20, 2016: World Journal of Surgery
https://www.readbyqxmd.com/read/27761157/current-topics-in-catecholaminergic-polymorphic-ventricular-tachycardia
#16
REVIEW
Naokata Sumitomo
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is induced by emotions or exercise in patients without organic heart disease and may be polymorphic or bidirectional in nature. The prognosis of CPVT is not good, and therefore prevention of sudden death is of utmost importance. Genetic variants of CPVT include RyR2, CASQ2, CALM2, TRD, and possibly KCNJ2 and ANK2 gene mutations. Hypotheses that suggest the causes of CPVT include weakened binding of FKBP12.6 and RyR2, a store overload-induced Ca(2+) release (SOICR), unzipping of intramolecular domain interactions in RyR2, and molecular and functional abnormalities caused by mutations in the CASQ2 gene...
October 2016: Journal of Arrhythmia
https://www.readbyqxmd.com/read/27754938/an-online-survey-of-dietary-and-phosphate-binder-practices-of-owners-of-cats-with-chronic-kidney-disease
#17
Sarah Ma Caney
OBJECTIVES: The objective of this study was to learn about owner experiences of chronic kidney disease (CKD), focusing on use of therapeutic renal diets (TRDs) and intestinal phosphate binders (IPBs). METHODS: An online survey was promoted to UK-based cat owners. RESULTS: In total, 859 owners participated. Most cats (n = 620; 72.18%) had two or more clinical signs at the time of their CKD diagnosis. Most common were polydipsia (n = 462; 53...
October 17, 2016: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/27721183/a-pilot-study-of-hippocampal-n-acetyl-aspartate-in-youth-with-treatment-resistant-major-depression
#18
Danielle Lefebvre, Lisa Marie Langevin, Natalia Jaworska, Ashley D Harris, R Marc Lebel, Yamile Jasaui, Adam Kirton, T Christopher Wilkes, Mariko Sembo, Rose Swansburg, Frank P MacMaster
BACKGROUND: Smaller hippocampal volumes, as assessed by magnetic resonance imaging (MRI), and proton magnetic resonance spectroscopy ((1)H-MRS) indexed alterations in brain metabolites have been identified in adults with major depressive disorder (MDD). Our group has found similar effects in MDD youth. However, this has not been studied in youth with treatment resistant MDD (TRD), nor has the interaction between regional N-acetyl-aspartate and volume deficits. N-acetyl-aspartate is an amino acid in the synthesis pathway of glutamate, and serves a marker of neuronal viability/number...
October 1, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27716050/erratum-to-genomic-and-expression-analyses-of-tursiops-truncatus-t-cell-receptor-gamma-trg-and-alpha-delta-tra-trd-loci-reveal-a-similar-basic-public-%C3%AE-%C3%AE-repertoire-in-dolphin-and-human
#19
Giovanna Linguiti, Rachele Antonacci, Gianluca Tasco, Francesco Grande, Rita Casadio, Serafina Massari, Vito Castelli, Arianna Consiglio, Marie-Paule Lefranc, Salvatrice Ciccarese
No abstract text is available yet for this article.
October 5, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27692695/adjunctive-5-hydroxytryptophan-slow-release-for-treatment-resistant-depression-clinical-and-preclinical-rationale
#20
Jacob P R Jacobsen, Andrew D Krystal, K Ranga R Krishnan, Marc G Caron
Serotonin transporter (SERT) inhibitors treat depression by elevating brain extracellular 5-hydroxytryptamine (5-HTExt). However, only one-third of patients respond adequately. Treatment-resistant depression (TRD) is a major unmet need. Interestingly, elevating 5-HTExt beyond what is achieved by a SERT inhibitor appears to treat TRD. Adjunctive administration of 5-hydroxytryptophan (5-HTP) safely elevates 5-HTExt beyond the SERT inhibitor effect in humans; however, 5-HTP cannot be a clinically viable drug because of its poor pharmacokinetics...
September 28, 2016: Trends in Pharmacological Sciences
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