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Juvenile arthritid

A Hinks, J Bowes, J Cobb, H C Ainsworth, M C Marion, M E Comeau, M Sudman, B Han, M L Becker, J F Bohnsack, P I W de Bakker, J P Haas, M Hazen, D J Lovell, P A Nigrovic, E Nordal, M Punnaro, A M Rosenberg, M Rygg, S L Smith, C A Wise, V Videm, L R Wedderburn, A Yarwood, R S M Yeung, S Prahalad, C D Langefeld, S Raychaudhuri, S D Thompson, W Thomson
OBJECTIVES: Juvenile idiopathic arthritis (JIA) is a heterogeneous group of diseases, comprising seven categories. Genetic data could potentially be used to help redefine JIA categories and improve the current classification system. The human leucocyte antigen (HLA) region is strongly associated with JIA. Fine-mapping of the region was performed to look for similarities and differences in HLA associations between the JIA categories and define correspondences with adult inflammatory arthritides...
December 20, 2016: Annals of the Rheumatic Diseases
Helen Slater, Joanne E Jordan, Jason Chua, Robert Schütze, John D Wark, Andrew M Briggs
OBJECTIVE: To investigate young people's experiences of persistent musculoskeletal pain, including care needs and current service gaps as well as perceptions about the role of digital technologies to support their co-care. METHODS: A qualitative study employing two independent data collection modes: in-depth individual semistructured interviews and focus groups. SETTING: Community settings throughout Australia. PARTICIPANTS: Participants were included if they had experienced persistent musculoskeletal pain of >3-month duration with an average of ≥3 on the visual analogue scale over the preceding 3 months, including non-specific conditions (eg, low back pain) and specific conditions (eg, juvenile idiopathic arthritis and other systemic arthritides), with/without pre-existing or current diagnosed mental health conditions...
December 9, 2016: BMJ Open
Paz Collado, Clara Malattia
Juvenile idiopathic arthritis (JIA) is a heterogeneous group of arthritides characterized by chronic synovial inflammation that can lead to structural damage. The main objective of JIA therapies is to induce disease control to avoid disability in childhood. The advances in therapeutic effectiveness have created a need to search for imaging tools that describe more precisely disease activity in children with JIA. Musculoskeletal ultrasound and magnetic resonance imaging have demonstrated to be more sensitive than clinical examination in early detection of synovitis...
August 2016: Best Practice & Research. Clinical Rheumatology
Gabriella Giancane, Alessandro Consolaro, Stefano Lanni, Sergio Davì, Benedetta Schiappapietra, Angelo Ravelli
Juvenile idiopathic arthritis is a broad term that describes a clinically heterogeneous group of arthritides of unknown cause, which begin before 16 years of age. This term encompasses several disease categories, each of which has distinct presentation, clinical manifestations, and, presumably, genetic background and etiopathogenesis. Although none of the available drugs has curative potential, prognosis has greatly improved as a result of substantial progresses in disease management. The most important new development has been the introduction of the biologic medications, which constitute a valuable treatment option for patients who are resistant to conventional antirheumatic agents...
December 2016: Rheumatology and Therapy
S El Assar de la Fuente, O Angenete, S Jellestad, N Tzaribachev, B Koos, K Rosendahl
Juvenile idiopathic arthritis is the most common inflammatory rheumatic disease of childhood and represents a series of chronic inflammatory arthritides of unknown cause. Involvement of the temporomandibular joint has been reported in up to 87% of children with juvenile idiopathic arthritis when based on magnetic tomography imaging; it can be asymptomatic and may lead to severe long term complications. In this review a summary of the contemporary literature of imaging of the temporomandibular joint in children with juvenile idiopathic arthritis will be provided, including ultrasound which is a valuable method for guided joint injections, but does not necessarily allow detection of acute inflammation, cone beam computed tomography, which has emerged as a feasible and accurate low-dose alternative as compared to conventional computed tomography to detect destructive change, and magnetic resonance imaging which is considered the method of choice for assessing acute, inflammatory change, although the lack of normative standards remains a challenge in children...
May 2016: Journal of Cranio-maxillo-facial Surgery
Malgorzata Rusak, Urszula Radzikowska, Barbara Glowinska-Olszewska, Elzbieta Dobrenko, Janina Piotrowska-Jastrzebska, Milena Dabrowska, Anna Bodzenta-Lukaszyk, Artur Bossowski, Marcin Moniuszko
BACKGROUND: Juvenile idiopathic arthritis (JIA), similarly to other arthritides, can be associated with damage of endothelial layer of which structure and function is dependent on reparative properties of endothelial progenitor cells (EPC). To date, it remained unknown whether EPC numbers are altered in young JIA patients and whether on-going anti-inflammatory therapies could exert positive effects on these progenitor cells. METHODS: We performed a quantitative analysis of EPC numbers in 25 patients diagnosed with JIA according to International League of Associations for Rheumatism (ILAR) criteria [age 11...
2015: Pediatric Rheumatology Online Journal
Ruy Carrasco
The temporomandibular joint (TMJ) is one of the many joints involved in the inflammatory arthritides. As imaging of joints has developed, so have the data regarding extent and prevalence of TMJ involvement in these diseases. TMJ disease is especially prevalent in juvenile arthritis. The adult and pediatric inflammatory arthritides share common pathophysiology but are still markedly different. The preponderance of TMJ arthritis research exists in juvenile arthritis. This article discusses classification, treatment, and TMJ involvement in juvenile idiopathic arthritis...
February 2015: Oral and Maxillofacial Surgery Clinics of North America
Donato Rigante, Annalisa Bosco, Susanna Esposito
Over the years, the commonly used term to describe juvenile idiopathic arthritis (JIA) has changed. By definition, JIA includes all types of arthritis with no apparent cause, lasting more than 6 weeks, in patients aged less than 16 years at onset. JIA pathogenesis is still poorly understood: the interaction between environmental factors and multiple genes has been proposed as the most relevant working mechanism to the development of JIA. The concept that various microbes that colonize or infect not only the mucosal surfaces, like the oral cavity, but also the airways and gut might trigger autoimmune processes, resulting in chronic arthritides, and JIA was first drafted at the outset of last century...
October 2015: Clinical Reviews in Allergy & Immunology
Susan Shenoi, Samantha Bell, Carol A Wallace, Beth A Mueller
OBJECTIVE: Cigarette smoking increases the risk of seropositive adult rheumatoid arthritis. The relationship of smoking with juvenile idiopathic arthritis (JIA), a heterogeneous group of 7 mutually exclusive categories of chronic childhood inflammatory arthritides, is unknown. Our objective was to evaluate the association between JIA and its categories with maternal prenatal smoking. METHODS: This case-control study used International Classification of Diseases, Ninth Revision codes from hospital records to identify 1,196 JIA cases born in Washington state and diagnosed at a quaternary pediatric center from 1997-2010...
May 2015: Arthritis Care & Research
Ma Khan, M Thyagiarajan, M Laugharne, J Clinch
BACKGROUND: Polyarticular disease affects one-third of all juvenile idiopathic arthritides. It affects girls twice as much as boys. It usually involves peripheral joints throughout the course of disease. It is unusual for cervical spine involvement to be the presenting symptoms of RF negative polyarthritis. CLINICAL CASE: This is the case of RF-negative polyarticular juvenile idiopathic arthritis that was reported with six-week history of neck pain, torticollis and left knee effusion...
August 2014: Scottish Medical Journal
M Consolo, A Amoroso, M Vinci
Juvenile idiopathic arthritides (JIA) comprehend a heterogeneous group of inflammatory diseases of the joints, with an unknown aetiology, arising within 16 years of age, and lasting more than six weeks. The systemic form, known as Still's disease, represents from 4 to 17% of all the JIA. AOSD (Adult Onset Still's Disease) is a variant of JIA affecting adults, with identical clinical manifestations. Here we describe the case of a 36 year old woman, with a symptomatology characterized by fever, skin rash, arthralgies and lymphadenopathy...
2014: La Clinica Terapeutica
Robin K Dore
Juvenile idiopathic arthritis (JIA) is a group of chronic inflammatory diseases affecting approximately 300,000 children and adolescents in the United States of unknown cause. It can affect children from the age of 0 years up to the age of 16 years. The International League of Associations of Rheumatology has defined seven subsets of JIA based on several factors including the number of affected joints and the involvement of other tissues; the prognosis for each affected child also depends on multiple factors including age of onset, number of joints involved, and systemic features...
2014: Adolescent Health, Medicine and Therapeutics
Christina Mertelsmann-Voss, Stephen Lyman, Ting Jung Pan, Susan M Goodman, Mark P Figgie, Lisa A Mandl
OBJECTIVE: Although rates of arthroplasty have increased dramatically, rates among patients with rheumatoid arthritis (RA) are reported to be decreasing. It is not known if this is also the case among patients with other inflammatory arthritides. This study was undertaken to evaluate rates of arthroplasty due to RA, juvenile idiopathic arthritis (JIA), spondyloarthritis (SpA), and a composite group of patients with inflammatory arthritides (IA), compared to arthroplasty rates among patients without inflammatory or autoimmune conditions...
June 2014: Arthritis & Rheumatology
Anand N Malaviya, Sujata Sawhney, Narinder K Mehra, Uma Kanga
This article summarises the available information on seronegative arthritides from South Asian countries, namely India, Pakistan, Bangladesh, Sri Lanka, Nepal, and Bhutan. The diseases described are spondyloarthritides (SpA), including ankylosing spondylitis (AS), psoriatic arthritis (PsA), reactive arthritis (ReA), inflammatory bowel disease-related arthritis (IBDa), enthesitis-related arthritis (ERA) of the paediatric age group, and undifferentiated spondyloarthritis (uSpA). Relevant information on SpA from South Asia is scarce...
April 2014: Current Rheumatology Reports
Oscar Epis, Franco Paoletti, Tito d'Errico, Ennio Favalli, Pietro Garau, Luana Mancarella, Giovanni Pomponio, Gilda Sandri, Crescenzio Scioscia, Enrico Selvi, Enrico Tirri
In primary care and internal medicine settings clinicians are often reluctant to take advantage of the resources that ultrasonography (US) offers as a diagnostic tool in the initial management of patients with inflammatory arthritis, despite the recognised importance of an accurate and timely diagnosis of rheumatoid arthritis (RA) and of early referral to ensure optimal patient management. Both grey-scale (GS) and power Doppler (PD) imaging have been extensively used in early detection of synovitis and bone erosions in patients with inflammatory arthritides...
February 2014: European Journal of Internal Medicine
Abdellah El Maghraoui
Juvenile idiopathic arthritis is a broad term that describes a clinically heterogeneous group of arthritides of unknown cause, which begin before 16 years of age. This term encompasses several disease categories, each of which has distinct clinical signs and, in some cases, genetic background. The cause of disease is still poorly understood but seems to be related to both genetic and environmental factors. Prognosis has greatly improved as a result of substantial progresses in disease management. The most important new development has been the introduction of drugs such as anticytokine agents, which constitute a valuable treatment option for patients who are resistant to conventional antirheumatic agents...
January 2014: La Presse Médicale
Elizabeth J Coulson, Wan-Fai Ng, Iain Goff, Helen E Foster
JIA is the most common chronic inflammatory arthritis in children and young people. More than one-third of individuals have persistent active disease into adulthood. In RA, there has been considerable interest in long-term cardiovascular outcomes. Increased cardiovascular mortality and morbidity have been observed and consensus guidelines recommend annual cardiovascular risk assessment for adults with RA. The increased risk is attributed to a higher prevalence of traditional cardiovascular risk factors and the role of systemic inflammation in the acceleration of atherosclerosis...
July 2013: Rheumatology
Yonatan Butbul Aviel, Pascal Tyrrell, Rayfel Schneider, Sandeep Dhillon, Brian M Feldman, Ronald Laxer, Rotraud K Saurenmann, Lynn Spiegel, Bonnie Cameron, Shirley Ml Tse, Earl Silverman
BACKGROUND: Following the introduction of the ILAR criteria for juvenile idiopathic arthritis, juvenile psoriatic arthritis (JPsA) has become a better recognized category within the inflammatory arthritides of childhood. There are fewer reports describing the characteristics and long-term outcome of patients with JPsA than other subtypes of JIA.The aim of our study was to determine the long-term outcome and clinical course of patients with juvenile psoriatic arthritis (JPsA) and to define subgroups of JPsA...
2013: Pediatric Rheumatology Online Journal
J Herman Kan
Juvenile idiopathic arthritis (JIA) represents a spectrum of non-pyogenic inflammatory arthritides affecting children. The purpose of this pictorial review is to illustrate the imaging spectrum of JIA and the role of radiology in disease diagnosis and management.
March 2013: Pediatric Radiology
M Navallas, M Rebollo Polo, L Riaza, J Muchart López, T Maristany
The term juvenile idiopathic arthritis (JIA) encompasses a heterogeneous group of arthritides with no known cause that begin before the age of 16 years and persist for at least 6 weeks. In recent decades, imaging techniques have acquired a fundamental role in the diagnosis and follow-up of JIA, owing to the unification of the different criteria for classification, which has strengthened the research in this field, and to the development of disease-modifying antirheumatic drugs. In this article, we briefly explain what JIA is...
September 2013: Radiología
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