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https://www.readbyqxmd.com/read/26231071/determinants-of-tolerance-to-inhibitors-in-hardwood-spent-sulfite-liquor-in-genome-shuffled-pachysolen-tannophilus-strains
#1
Nicole K Harner, Paramjit K Bajwa, Philip A Formusa, Glen D Austin, Marc B Habash, Jack T Trevors, Chi-Kin Chan, Chi-Yip Ho, Hung Lee
Genome shuffling was used to obtain Pachysolen tannophilus mutants with improved tolerance to inhibitors in hardwood spent sulfite liquor (HW SSL). Genome shuffled strains (GHW301, GHW302 and GHW303) grew at higher concentrations of HW SSL (80 % v/v) compared to the HW SSL UV mutant (70 % v/v) and the wild-type (WT) strain (50 % v/v). In defined media containing acetic acid (0.70-0.90 % w/v), GHW301, GHW302 and GHW303 exhibited a shorter lag compared to the acetic acid UV mutant, while the WT did not grow. Genome shuffled strains produced more ethanol than the WT at higher concentrations of HW SSL and an aspen hydrolysate...
October 2015: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/26097183/a-baff-receptor-his159tyr-mutation-in-sj%C3%A3-gren-s-syndrome-related-lymphoproliferation
#2
Aristea Papageorgiou, Clio P Mavragani, Andrianos Nezos, Elias Zintzaras, Luca Quartuccio, Salvatore De Vita, Michael Koutsilieris, Athanasios G Tzioufas, Haralampos M Moutsopoulos, Michael Voulgarelis
OBJECTIVE: To study the prevalence, clinical associations, and functional implications of the His159Tyr mutation of the BAFF receptor (BAFF-R) in patients with Sjögren's syndrome (SS). METHODS: The BAFF-R His159Tyr mutation was evaluated using polymerase chain reaction (PCR)-based assays in 247 patients with SS (of whom 70 had SS complicated by lymphoma [SS-lymphoma]), 145 with systemic lupus erythematosus (SLE), and 101 with rheumatoid arthritis (RA), as well as 180 healthy controls...
October 2015: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/26087869/does-ligand-receptor-mediated-competitive-effect-or-penetrating-effect-of-irgd-peptide-when-co-administration-with-irgd-modified-ssl
#3
Wei-Qiang Zhang, Ke-Fu Yu, Ting Zhong, Li-Min Luo, Ruo Du, Wei Ren, Dan Huang, Ping Song, Dan Li, Yang Zhao, Chao Wang, Xuan Zhang
Ligand-mediated targeting of anticancer therapeutic agents is a useful strategy for improving anti-tumor efficacy. It has been reported that co-administration of a tumor-penetrating peptide iRGD (CRGDK/RGPD/EC) enhances the efficacy of anticancer drugs. Here, we designed an experiment involving co-administration of iRGD-SSL-DOX with free iRGD to B16-F10 tumor bearing mice to examine the action of free iRGD. We also designed an experiment to investigate the location of iRGD-modified SSL when co-administered with free iRGD or free RGD to B16-F10 tumor bearing nude mice...
December 2015: Journal of Drug Targeting
https://www.readbyqxmd.com/read/26031292/activation-of-the-pi3k-akt-mtor-and-mapk-signaling-pathways-in-response-to-acute-solar-simulated-light-exposure-of-human-skin
#4
RANDOMIZED CONTROLLED TRIAL
Yira Bermudez, Steven P Stratton, Clara Curiel-Lewandrowski, James Warneke, Chengcheng Hu, George T Bowden, Sally E Dickinson, Zigang Dong, Ann M Bode, Kathylynn Saboda, Christine A Brooks, Emanuel F Petricoin, Craig A Hurst, David S Alberts, Janine G Einspahr
The incidence of skin cancer is higher than all other cancers and continues to increase, with an average annual cost over $8 billion in the United States. As a result, identifying molecular pathway alterations that occur with UV exposure to strategize more effective preventive and therapeutic approaches is essential. To that end, we evaluated phosphorylation of proteins within the PI3K/Akt and MAPK pathways by immunohistochemistry in sun-protected skin after acute doses of physiologically relevant solar-simulated ultraviolet light (SSL) in 24 volunteers...
August 2015: Cancer Prevention Research
https://www.readbyqxmd.com/read/26025401/comparison-of-two-codon-optimization-strategies-enhancing-recombinant-sus-scrofa-lysozyme-production-in-pichia-pastoris
#5
COMPARATIVE STUDY
D Zhu, G Cai, D Wu, J Lu
Lysozyme has played an important role in animal feed additive industry, food additive industry and biological engineering. For improving expression efficiency of recombinant lysozyme from Sus scrofa, two genes respectively designed by the most used codon optimization strategies, "one amino acid one codon" and "codon randomization", were synthesized and expressed in Pichia pastoris X—33. At shaking flask level, Sus scrofa lysozyme (SSL) under two conditions had a highest activity of 153.33±10.41 and 538...
2015: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/26014122/a-new-type-of-signaling-pathways-as-pilomotor-lines-along-skin-for-transmitting-acupuncture-signals-to-produce-acupuncture-effects
#6
Li-Yuan Liu
In our previous study, we observed a linear system consisted of sympathetic endings in the arrector pili muscles (AP muscles) along the rat skin termed sympathetic substance lines, or SSLs. After shaving the hair of the rats, the first wave of hair re-growth was not evenly distributed, but followed specific hair loop lines (HLLs). The patterns of HLL and SSL correspond with each other and also with the "Meridians" described in Chinese traditional medicine (CTM). Here I investigated in rabbits and rats whether the acupuncture signals are transmitted via the SSL/HLL, and whether the acupuncture analgesia (AA) is dependent on any peripheral mechanism...
June 30, 2015: Chinese Journal of Physiology
https://www.readbyqxmd.com/read/25961091/successive-overrelaxation-for-laplacian-support-vector-machine
#7
Zhiquan Qi, Yingjie Tian, Yong Shi
Semisupervised learning (SSL) problem, which makes use of both a large amount of cheap unlabeled data and a few unlabeled data for training, in the last few years, has attracted amounts of attention in machine learning and data mining. Exploiting the manifold regularization (MR), Belkin et al. proposed a new semisupervised classification algorithm: Laplacian support vector machines (LapSVMs), and have shown the state-of-the-art performance in SSL field. To further improve the LapSVMs, we proposed a fast Laplacian SVM (FLapSVM) solver for classification...
April 2015: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/25910093/learning-a-nonnegative-sparse-graph-for-linear-regression
#8
Xiaozhao Fang, Yong Xu, Xuelong Li, Zhihui Lai, Wai Keung Wong
Previous graph-based semisupervised learning (G-SSL) methods have the following drawbacks: 1) they usually predefine the graph structure and then use it to perform label prediction, which cannot guarantee an overall optimum and 2) they only focus on the label prediction or the graph structure construction but are not competent in handling new samples. To this end, a novel nonnegative sparse graph (NNSG) learning method was first proposed. Then, both the label prediction and projection learning were integrated into linear regression...
September 2015: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/25829412/optimal-number-of-angle-images-for-calculating-anterior-angle-volume-and-iris-volume-measurements
#9
Lauren S Blieden, Alice Z Chuang, Laura A Baker, Nicholas P Bell, Timothy S Fuller, Kimberly A Mankiewicz, Robert M Feldman
PURPOSE: We determined the optimal number of angle images required to obtain reliable measurements of trabecular-iris circumferential volume (TICV) and iris volume (IV) using swept-source Fourier domain anterior segment optical coherence tomography (SSFD-ASOCT) scans in narrow angle eyes. METHODS: Scleral spur landmarks (SSL) were manually identified on ASOCT angle images from 128 meridians from each of 24 eyes with chronic primary angle closure (PAC) spectrum of disease...
May 2015: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/25823498/does-dopamine-replacement-medication-affect-postural-sequence-learning-in-parkinson-s-disease
#10
Heather Anne Hayes, Nikelle Hunsaker, Sydney Y Schaefer, Barry Shultz, Thomas Schenkenberg, Lara A Boyd, Andrea T White, Kenneth B Foreman, Philip Dyer, Rebecca Maletsky, Leland E Dibble
Deficits in sequence-specific learning (SSL) may be a product of Parkinson's disease (PD) but this deficit could also be related to dopamine replacement. The purpose of this study was to determine whether dopamine replacement affected acquisition and retention of a standing Continuous Tracking Task in individuals with PD. SSL (difference between random/repeated Root Mean Square Error across trials) was calculated over 2 days of practice and 1 day of retention for 4 groups; 10 healthy young (HY), 10 healthy elders, 10 individuals with PD on, 9 individuals with PD off their usual dosage of dopamine replacement...
October 2015: Motor Control
https://www.readbyqxmd.com/read/25708741/hyperplastic-polyps-of-the-colon-and-rectum-reclassification-braf-and-kras-status-in-index-polyps-and-subsequent-colorectal-carcinoma
#11
Huma Gul Rehana Janjua, Estrid Høgdall, Dorte Linnemann
Hyperplastic polyps (HP) of the colon and rectum were previously considered benign. Newer studies have suggested that colorectal HP are different entities. The aim of this study was to reclassify lesions from a 5-year period previously classified as colorectal HP into traditional hyperplastic polyp (THP), sessile serrated lesions (SSL), and other lesions. All patients were confirmed in the Danish National Pathology Database for the occurrence of metachronous polyps/adenomas, colorectal cancer (CRC), and other gastrointestinal malignancies...
April 2015: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/25608310/deformed-graph-laplacian-for-semisupervised-learning
#12
Chen Gong, Tongliang Liu, Dacheng Tao, Keren Fu, Enmei Tu, Jie Yang
Graph Laplacian has been widely exploited in traditional graph-based semisupervised learning (SSL) algorithms to regulate the labels of examples that vary smoothly on the graph. Although it achieves a promising performance in both transductive and inductive learning, it is not effective for handling ambiguous examples (shown in Fig. 1). This paper introduces deformed graph Laplacian (DGL) and presents label prediction via DGL (LPDGL) for SSL. The local smoothness term used in LPDGL, which regularizes examples and their neighbors locally, is able to improve classification accuracy by properly dealing with ambiguous examples...
October 2015: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/25446543/single-site-laparoscopy-for-fertility-preservation-a-cohort-study
#13
María José Núñez Valera, Pablo Padilla Iserte, Gema Higueras García, Sonia Herraiz, José María Rubio, Mónica Romeu Villarroya, Antonio Pellicer, César Díaz-García
STUDY OBJECTIVE: To compare operative and postoperative results of ovarian cortex retrieval by conventional laparoscopy (1cm umbilical site and 3 accessory 5-mm-reusable working ports) (HASS) versus single site laparoscopy (SSL). DESIGN: Prospective cohort study. SETTING: Fertility Preservation Programme at La Fe University Hospital-University of Valencia, Valencia, Spain, 2011 to 2012. Fertility Preservation Programme at La Fe University Hospital of Valencia, Valencia, Spain...
February 2015: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/25404868/using-frankencerts-for-automated-adversarial-testing-of-certificate-validation-in-ssl-tls-implementations
#14
Chad Brubaker, Suman Jana, Baishakhi Ray, Sarfraz Khurshid, Vitaly Shmatikov
Modern network security rests on the Secure Sockets Layer (SSL) and Transport Layer Security (TLS) protocols. Distributed systems, mobile and desktop applications, embedded devices, and all of secure Web rely on SSL/TLS for protection against network attacks. This protection critically depends on whether SSL/TLS clients correctly validate X.509 certificates presented by servers during the SSL/TLS handshake protocol. We design, implement, and apply the first methodology for large-scale testing of certificate validation logic in SSL/TLS implementations...
2014: IEEE Security & Privacy
https://www.readbyqxmd.com/read/25307082/hernia-incidence-following-single-site-vs-standard-laparoscopic-colorectal-surgery
#15
COMPARATIVE STUDY
W Sangster, A N Kulaylat, D B Stewart, J R Schubart, W A Koltun, E Messaris
AIM: Compared with standard laparoscopic (SDL) approaches, less is known about the incidence of hernias after single-site laparoscopic (SSL) colorectal surgery. This study hypothesized that SSL colorectal surgery was associated with an increased risk of hernia development. METHOD: Institutional retrospective chart review (September 2008-June 2013) identified 276 evaluable patients who underwent laparoscopic colorectal procedures. The following data were collected: demographic data, risk factors for the development of a hernia, operative details and postoperative course including the development of a hernia...
March 2015: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/25169870/pesticide-mobility-and-leachate-toxicity-in-two-abandoned-mine-soils-effect-of-organic-amendments
#16
José Antonio Rodríguez-Liébana, M Dolores Mingorance, Aránzazu Peña
Abandoned mine areas, used in the past for the extraction of minerals, constitute a degraded landscape which needs to be reintegrated to productive or leisure activities. However these soils, mainly composed by silt or sand and with low organic matter content, are vulnerable to organic and inorganic pollutants posing a risk to the surrounding ecosystems and groundwater. Soils from two mining areas from Andalusia were evaluated: one from Nerva (NCL) in the Iberian Pyrite Belt (SW Andalusia) and another one from the iron Alquife mine (ALQ) (SE Andalusia)...
November 1, 2014: Science of the Total Environment
https://www.readbyqxmd.com/read/25028548/antitumor-effect-of-irgd-modified-liposomes-containing-conjugated-linoleic-acid-paclitaxel-cla-ptx-on-b16-f10-melanoma
#17
Ruo Du, Ting Zhong, Wei-Qiang Zhang, Ping Song, Wen-Ding Song, Yang Zhao, Chao Wang, Yi-Qun Tang, Xuan Zhang, Qiang Zhang
In the present study, we prepared a novel delivery system of iRGD (CRGDK/RGPD/EC)-modified sterically stabilized liposomes (SSLs) containing conjugated linoleic acid-paclitaxel (CLA-PTX). The anti-tumor effect of iRGD-SSL-CLA-PTX was investigated on B16-F10 melanoma in vitro and in vivo. The in vitro targeting effect of iRGD-modified SSLs was investigated in a real-time confocal microscopic analysis experiment. An endocytosis-inhibition assay was used to evaluate the endocytosis pathways of the iRGD-modified SSLs...
2014: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/24999861/integrating-video-feedback-and-cognitive-preparation-social-skills-training-and-behavioural-activation-in-a-cognitive-behavioural-therapy-in-the-treatment-of-childhood-anxiety
#18
Cecilia A Essau, Beatriz Olaya, Satoko Sasagawa, Jayshree Pithia, Diane Bray, Thomas H Ollendick
BACKGROUND: The present study examined the effectiveness of a transdiagnostic prevention programme, Super Skills for Life (SSL), in children with anxiety problems. SSL is based on the principles of cognitive-behaviour therapy (CBT), behavioural activation, social skills training, and uses video-feedback and cognitive preparation as part of the treatment. METHODS: Participants were 61 primary school children, aged 8-10 years, who were referred by their teachers as having significant anxiety problems...
2014: Journal of Affective Disorders
https://www.readbyqxmd.com/read/24983761/improving-response-to-foodborne-disease-outbreaks-in-the-united-states-findings-of-the-foodborne-disease-centers-for-outbreak-response-enhancement-foodcore-2010-2012
#19
Gwen Kathryn Biggerstaff
CONTEXT: Each year foodborne diseases (FBD) affect approximately 1 in 6 Americans, resulting in 128 000 hospitalizations and 3000 deaths. Decreasing resources impact the ability of public health officials to identify, respond to, and control FBD outbreaks. Geographically dispersed outbreaks necessitate multijurisdictional coordination across all levels of the public health system. Rapid response depends on rapid detection. OBJECTIVE: Targeted resources were provided to state and local health departments to improve completeness and timeliness of laboratory, epidemiology, and environmental health (EH) activities for FBD surveillance and outbreak response...
July 2015: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/24978086/gluteal-and-posterior-thigh-pain-in-the-postoperative-period-and-the-need-for-intervention-after-sacrospinous-ligament-colpopexy
#20
Cecile A Unger, Mark D Walters
INTRODUCTION: Sacrospinous ligament (SSL) colpopexy is a transvaginal surgical option for the treatment of vaginal apex prolapse. The objective of this study was to determine the rate of gluteal and posterior thigh pain after SSL colpopexy using the Capio device in the immediate postoperative period, at the 6-week postoperative visit, and to determine the risk of needing intervention for this type of pain. METHODS: This was a retrospective cohort study of women who underwent SSL colpopexy with the Capio device for the treatment of vaginal apex prolapse between 2007 and 2012...
July 2014: Female Pelvic Medicine & Reconstructive Surgery
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