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https://www.readbyqxmd.com/read/29351333/simultaneous-quantification-of-four-antiretroviral-drugs-in-breast-milk-samples-from-hiv-positive-women-by-an-ultra-high-performance-liquid-chromatography-tandem-mass-spectrometry-uplc-ms-ms-method
#1
Alicia Ramírez-Ramírez, Elías Sánchez-Serrano, Giselle Loaiza-Flores, Noemí Plazola-Camacho, Rosa Georgina Rodríguez-Delgado, Ricardo Figueroa-Damián, Mauricio Domínguez-Castro, Margarita López-Martínez, Zayra Flores-García, Jessica Hernández-Pineda
The primary strategy to avoid mother-to-child transmission of human immunodeficiency virus (HIV) through breastfeeding is administration of highly active antiretroviral therapy (HAART) to HIV-positive pregnant women. Because significant changes in the pharmacokinetics of antiretroviral (ARV) drugs occur during pregnancy, quantifying HAART and the viral load in breast milk in this population is essential. Here, we developed an analytical assay for the simultaneous quantification of four ARV drugs in breast milk using ultra-performance liquid chromatography coupled to tandem mass spectrometry...
2018: PloS One
https://www.readbyqxmd.com/read/29350308/the-ppar%C3%AE-agonist-efatutazone-delays-invasive-progression-and-induces-differentiation-of-ductal-carcinoma-in-situ
#2
Virginie Ory, William B Kietzman, Jacob Boeckelman, Bhaskar V Kallakury, Anton Wellstein, Priscilla A Furth, Anna T Riegel
PURPOSE: Ductal carcinoma in situ (DCIS) is a pre-invasive lesion of the breast considered a precursor of invasive ductal carcinoma. This study aimed to determine whether activated PPARγ acts as a tumor suppressor in human DCIS progression. METHODS: We utilized the high-affinity PPARγ agonist, efatutazone, to activate endogenous PPARγ in a well-defined model for the progression of basal (triple negative) DCIS, MCFDCIS cells, cultured under 2D and 3D conditions...
January 19, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29350290/the-microbiology-and-treatment-of-human-mastitis
#3
REVIEW
Angeliki Angelopoulou, Des Field, C Anthony Ryan, Catherine Stanton, Colin Hill, R Paul Ross
Mastitis, which is generally described as an inflammation of breast tissue, is a common and debilitating disease which frequently results in the cessation of exclusive breastfeeding and affects up to 33% of lactating women. The condition is a primary cause of decreased milk production and results in organoleptic and nutritional alterations in milk quality. Recent studies employing culture-independent techniques, including metagenomic sequencing, have revealed a loss of bacterial diversity in the microbiome of mastitic milk samples compared to healthy milk samples...
January 19, 2018: Medical Microbiology and Immunology
https://www.readbyqxmd.com/read/29350166/cronobacter-sakazakii-infection-from-expressed-breast-milk-australia
#4
Rowena McMullan, Vidthiya Menon, Alicia G Beukers, Slade O Jensen, Sebastiaan J van Hal, Rebecca Davis
Cronobacter sakazakii neonatal infections are often epidemiologically linked to the consumption of contaminated powdered infant formula. We describe a case resulting from consumption of contaminated expressed breast milk, as confirmed by whole-genome sequencing. This case highlights potential risks associated with storage and acquisition of expressed breast milk.
February 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29349922/association-between-breast-milk-intake-at-9-10%C3%A2-months-of-age-and-growth-and-development-among-malawian-young-children
#5
Chiza Kumwenda, Jaimie Hemsworth, John Phuka, Ulla Ashorn, Mary Arimond, Kenneth Maleta, Elizabeth L Prado, Marjorie J Haskell, Kathryn G Dewey, Per Ashorn
World Health Organization recommends exclusive breastfeeding for infants for the first 6 months of life, followed by introduction of nutritious complementary foods alongside breastfeeding. Breast milk remains a significant source of nourishment in the second half of infancy and beyond; however, it is not clear whether more breast milk is always better. The present study was designed to determine the association between amount of breast milk intake at 9-10 months of age and infant growth and development by 12-18 months of age...
January 19, 2018: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/29349652/social-factors-associated-with-non-initiation-and-cessation-of-predominant-breastfeeding-in-a-mother-child-cohort-in-spain
#6
Maria Villar, Loreto Santa-Marina, Mario Murcia, Pilar Amiano, Silvia Gimeno, Ferran Ballester, Jordi Julvez, Dora Romaguera, Ana Fernández-Somoano, Adonina Tardón, Jesús Ibarluzea
Objective The aim of the study was to identify factors associated with non-initiation and cessation of predominant breastfeeding (PBF) in a mother-child cohort from Spain. Materials and Methods The analysis included 2195 mother-infant from birth to 14 months post- delivery recruited between 2004 and 2008. Maternal characteristics were collected during the pregnancy. Lactation data were obtained at 6 and 14 months after delivery. PBF was defined as intake of breast milk plus liquids like juices or water. The PBF cessation was calculated using the date that women started PBF and the date that she reported to start giving infant formula and/or food...
January 18, 2018: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/29349441/association-between-sn-2-fatty-acid-profiles-of-breast-milk-and-development-of-the-infant-intestinal-microbiome
#7
Tiemin Jiang, Bin Liu, Jufang Li, Xueyan Dong, Man Lin, Minghui Zhang, Junying Zhao, Yaohua Dai, Lijun Chen
Increasing evidence shows that host diet and gut microbes are related. Previous studies have shown the effects of specific dietary fatty acids (FAs) on intestinal microbiota, but little is known about the effect of the stereospecifically numbered sn-2 position in triglycerides (TG) of human milk on the gut microbiome of infants. This study aimed at examining possible effects of sn-2 FAs of human milk on the gut microbial development of breastfeeding babies. Sn-2 FAs and intestinal microbiota were assessed by GC-MS and high-throughput 16S rRNA sequencing, respectively...
January 19, 2018: Food & Function
https://www.readbyqxmd.com/read/29345286/cyclooxygenase-2-expression-is-induced-by-celecoxib-treatment-in-lung-cancer-cells-and-is-transferred-to-neighbor-cells-via-exosomes
#8
Jayoung Kim, Seung-Woo Hong, Seonghan Kim, Daejin Kim, Dae Young Hur, Dong-Hoon Jin, Bomi Kim, Yeong Seok Kim
Lung cancer is one of most common types of cancer worldwide. Lung cancer results in a death higher rate each year compared to colon, breast and prostate cancer combined. Celecoxib is a selective inhibitor of cyclooxygenase-2 (COX‑2), an enzyme of which the expression is induced by various stimuli, such as inflammation. In addition, celecoxib triggers COX-2 loading on exosomes. Exosomes are small vesicles composed of a lipid bilayer membrane and are found in most biological fluids, such as blood breast milk and urine...
February 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29344587/an-exploratory-study-of-red-raspberry-rubus-idaeus-l-poly-phenols-metabolites-in-human-biological-samples
#9
Xuhuiqun Zhang, Amandeep Sandhu, Indika Edirisinghe, Britt Burton-Freeman
Red raspberry (Rubus idaeus L.) contains a variety of polyphenols including anthocyanins and ellagitannins. Red raspberry polyphenols absorbed in different forms (parent compounds, degradants or microbial metabolites) are subject to xenobiotic metabolism in the intestine, liver, and/or kidney, forming methylate, glucuronide, and sulfate conjugated metabolites. Upon acute exposure, (poly)phenol/metabolite presence in the blood depends mainly on intestinal absorption, enterohepatic circulation, and metabolism by resident microbiota...
January 18, 2018: Food & Function
https://www.readbyqxmd.com/read/29344559/infant-feeding-regimens-and-gastrointestinal-tolerance-a-multicenter-prospective-observational-cohort-study-in-china
#10
Meng Mao, Lan Zhang, John Ge, Jian Yan, Robert Northington, Manjiang Yao, Joyce Nowacki, Nicholas P Hays
To study feeding tolerance in infants fed formula with increased sn-2 palmitate and oligofructose (sn-2+OF) in a real-world setting, healthy Chinese infants were enrolled in this 48-day observational study on their current feeding regimens: exclusively breastfed (BF; n = 147), exclusively sn-2+OF formula-fed (FF; n = 150), or mixed-fed with breast milk and sn-2+OF formula (MF; n = 163). Throughout the study, incidence (90% confidence interval) of hard stools was ≤2.1% (0.0-5.3) in FF and 0.8% (0.0-3.5) in MF, with no hard stools in BF...
2018: Global Pediatric Health
https://www.readbyqxmd.com/read/29340904/turkish-women-s-knowledge-attitudes-and-behaviors-on-wet-nursing-milk-sharing-and-human-milk-banking
#11
Ahmet Ergin, S Utku Uzun
Purpose The aim of this study was to determine Turkish women's knowledge, attitudes, and behaviors on wet-nursing, milk sharing, and human milk banking in a primary care setting located in a semi-rural area. Description Donated human milk is a feasible option for feeding infants and children. Currently, there is a debate on the topic starts with the preparations to launch a human milk bank in a large city in Turkey. Several previous papers reported women's opinions in large hospital based studies. Little is known about women's views and practice on donated human milk in the rural areas of Turkey...
January 16, 2018: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/29336526/human-milk-oligosaccharides-as-promising-antivirals
#12
REVIEW
Vasily Morozov, Grant Hansman, Franz-Georg Hanisch, Horst Schroten, Clemens Kunz
Human milk oligosaccharides (HMOs) are diverse unconjugated carbohydrates that are highly abundant in human breast milk. These glycans are investigated in the context of exhibiting multiple functions in infant growth and development. They seem to provide protection against infectious diseases, including a number of poorly manageable viral infections. Although the potential mechanism of the HMO antiviral protection is rather broad, much of the current experimental work has focused on studying of HMO antiadhesive properties...
January 16, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29334651/effects-of-perinatal-fluoride-exposure-on-the-expressions-of-mir-124-and-mir-132-in-hippocampus-of-mouse-pups
#13
Jixiang Wang, Yuliang Zhang, Zhenzhen Guo, Rui Li, Xingchen Xue, Zilong Sun, Ruiyan Niu
To investigate the effects of perinatal fluoride exposure on learning and memory ability of mouse offspring, ICR female mice were received different doses of sodium fluoride (0, 25, 50, 100 mg/L NaF) from pregnant day 7 to lactational day 21. Pups were exposed to fluoride through the cord blood and breast milk. Open field test showed that compared to the control group, perinatal fluoride exposure significantly decreased the number of entries into the center zone in 100 mg/L NaF group. In the eight-arm maze test, the number of working memory errors, reference memory errors, and the total arm entries were significantly increased in fluoride treatment groups, compared to the control group...
January 8, 2018: Chemosphere
https://www.readbyqxmd.com/read/29334343/breast-milk-iodine-concentrations-and-iodine-levels-of-infants-according-to-the-iodine-status-of-the-country-of-residence-a-systematic-review-and-meta-analysis
#14
Pantea Nazeri, Ali Kabir, Hosein Dalili, Parvin Mirmiran, Fereidoun Azizi
BACKGROUND: Iodine, an essential micronutrient, plays a critical role in normal growth and development, especially during the first two years of life. This systematic review and meta-analysis is among the first to evaluate breast-milk iodine concentrations and infant iodine status in countries characterized by iodine sufficiency or deficiency. METHODS: PubMed, Web of Science, Cochrane Library, Google Scholar, and other relevant databases, as well as reference lists of previous reviews, were searched for relevant studies published between 1986 and 2016...
January 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29332276/variability-and-reliability-of-pop-concentrations-in-multiple-breast-milk-samples-collected-from-the-same-mothers
#15
Risa Kakimoto, Masayoshi Ichiba, Akiko Matsumoto, Kunihiko Nakai, Nozomi Tatsuta, Miyuki Iwai-Shimada, Momoko Ishiyama, Noriko Ryuda, Takashi Someya, Ieyasu Tokumoto, Daisuke Ueno
Risk assessment of infant using a realistic persistent organic pollutant (POP) exposure through breast milk is essential to devise future regulation of POPs. However, recent investigations have demonstrated that POP levels in breast milk collected from the same mother showed a wide range of variation daily and monthly. To estimate the appropriate sample size of breast milk from the same mother to obtain reliable POP concentrations, breast milk samples were collected from five mothers living in Japan from 2006 to 2012...
January 13, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29331797/application-of-polyacrylamide-gel-as-a-new-membrane-in-electromembrane-extraction-for-the-quantification-of-basic-drugs-in-breast-milk-and-wastewater-samples
#16
Sakine Asadi, Hadi Tabani, Saeed Nojavan
Introducing new membranes with green chemistry approach seems to be a great challenge for the development of a practical method in separation science. In this regard, for the first time, polyacrylamide gel as a new membrane in electromembrane extraction (EME) was used for the extraction of three model basic drugs (pseudoephedrine (PSE), lidocaine (LID), and propranolol (PRO)), followed by HPLC-UV. In comparison with conventional EME, in this method neither organic solvent nor carrier agents were used for extraction of mentioned drugs...
January 9, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29331368/in-vitro-and-in-vivo-safety-analysis-of-enterococcus-faecium-2c-isolated-from-human-breast-milk
#17
Soodabeh Khalkhali, Naheed Mojgani
INTRODUCTION: Safety analysis of probiotic bacteria is an obligatory characteristic to be evaluated prior to application in food or pharmacological products. This study was designed to evaluate in vitro and in vivo safety parameters of Enterococcus faecium 2C strain, a probiotic candidate isolated from human breast milk. MATERIAL AND METHODS: E.faecium 2C was studied for its hemolytic activity and phenotypic antibiotics resistance profile. In vivo safety of the mentioned Enterococcus strain was studied by determining acute oral toxicity in Wistar Male rats...
January 10, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29324318/a-feasibility-study-of-a-multidimensional-breastfeeding-support-intervention-in-ireland
#18
Goiuri Alberdi, Elizabeth J O'Sullivan, Helena Scully, Niamh Kelly, Regina Kincaid, Rosie Murtagh, Stephanie Murray, Denise McGuinness, Ashamole Clive, Mary Brosnan, Lucille Sheehy, Elizabeth Dunn, Fionnuala M McAuliffe
BACKGROUND: Breastfeeding is the optimum mode of infant feeding. Despite this, most global populations do not achieve the World Health Organisation's recommendation of exclusive breast milk for the first 6 months of life. Irish breastfeeding rates are among the lowest in Europe, necessitating a well-designed breastfeeding-support intervention. AIM: To evaluate the feasibility and acceptability of a multidimensional breastfeeding intervention in a rural and an urban maternity setting in Ireland...
December 24, 2017: Midwifery
https://www.readbyqxmd.com/read/29317437/infant-feeding-practices-among-hiv-exposed-infants-less-than-6-months-of-age-in-bomet-county-kenya-an-in-depth-qualitative-study-of-feeding-choices
#19
Purity Chepkorir Lang'at, Irene Ogada, Audrey Steenbeek, Noni E MacDonald, Sophie Ochola, Wesley Bor, Godfrey Odinga
BACKGROUND: In children, HIV can be acquired from the mother during pregnancy, delivery and through breast milk. The WHO recommends exclusive breast feeding or exclusive replacement feeding for the first 6 months after birth for HIV-exposed infants. Barriers such as HIV-related stigma, inadequate resources, lack of access to safe water and negative cultural beliefs have been shown to influence infant feeding among HIV-exposed infants in some settings. In Kenya, there is limited literature on the barriers...
January 9, 2018: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29316209/infant-and-young-child-feeding-in-emergencies-organisational-policies-and-activities-during-the-refugee-crisis-in-lebanon
#20
Linda Shaker-Berbari, Hala Ghattas, Andrew G Symon, Annie S Anderson
Appropriate infant and young child feeding (IYCF) is key to reducing mortality amongst children aged under 2. Facilitating adherence to recommended IYCF practices during emergencies includes having relevant policies to support breastfeeding and complementary feeding as well as regulating the distribution of breast milk substitutes. In the current crisis, more than 1.2 million Syrian refugees are in Lebanon and it is timely to examine organisational IYCF policies and programmes. One hundred and thirty-five non-governmental organisations providing humanitarian aid in Lebanon were invited to participate in an online survey about organisational policies and programmatic activities on IYCF...
January 8, 2018: Maternal & Child Nutrition
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