keyword
https://read.qxmd.com/read/38524555/cervical-misalignment-in-motorcyclists-in-relation-to-new-helmet-removal-recommendations-shown-with-augmented-reality-resources-a-biomechanical-analysis
#21
JOURNAL ARTICLE
Ana Nicolás Carrillo, Javier Ruiz Casquet, Juan José Hernández Morante, Francisco Gallego España, MaryBeth Horodyski, Catalina Baez, Manuel Pardo Ríos
OBJECTIVE: The aim of this study is to determine the best technique and position for helmet removal in injured motorcyclists by comparing cervical misalignment produced in the supine position and prone position. METHOD: Comparative cross-sectional clinical simulation study to quantify CM using biomechanical analysis with the use of inertial systems. The main variable was determined for the flexion-extension motion. The extraction was tested for both positions (prone position and supine position), which were repeated 3 times for each of the 30 volunteers included, and the movement from the initial neutral position was also determined, resulting in a total of 270 biomechanical studies...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38524444/prioritizing-biomaterial-driven-clinical-bioactivity-over-designing-intricacy-during-bioprinting-of-trabecular-microarchitecture-a-clinician-s-perspective
#22
REVIEW
Sahith Kumar Shetty, Shyam Sundar Santhanakrishnan, Shubha Padurao, Pandareesh Mirazkar Dasharatharao
Bone tissue engineering has witnessed a historical shift from three perspectives. From a biomaterial perspective, materials have now become smarter and dynamic; from a bioengineering perspective the bioprinting techniques have now advanced to 4D bioprinting; and from a clinical perspective scaffold bioactivity has progressed toward enhanced osteoinductive scaffolds driven by intricate biomechanical, biophysical, biochemical, and biological cues. Though all of these advancements are indicative of improvised scaffold engineering, a pivotal question regarding the critical role and need of designing and replicating the intricacies of trabecular microarchitecture for enhanced, clinically appreciable osteoangiogenicity needs to be answered...
March 19, 2024: ACS Omega
https://read.qxmd.com/read/38524192/experimental-and-virtual-testing-of-bone-implant-systems-equipped-with-the-ao-fracture-monitor-with-regard-to-interfragmentary-movement
#23
JOURNAL ARTICLE
Kerstin Wickert, Michael Roland, Annchristin Andres, Stefan Diebels, Bergita Ganse, Dorothea Kerner, Felix Frenzel, Thomas Tschernig, Manuela Ernst, Markus Windolf, Max Müller, Tim Pohlemann, Marcel Orth
Introduction: The management of fractured bones is a key domain within orthopedic trauma surgery, with the prevention of delayed healing and non-unions forming a core challenge. This study evaluates the efficacy of the AO Fracture Monitor in conjunction with biomechanical simulations to better understand the local mechanics of fracture gaps, which is crucial for comprehending mechanotransduction, a key factor in bone healing. Through a series of experiments and corresponding simulations, the study tests four hypotheses to determine the relationship between physical measurements and the predictive power of biomechanical models...
2024: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/38523806/using-convolutional-neural-network-based-segmentation-for-image-based-computational-fluid-dynamics-simulations-of-brain-aneurysms-initial-experience-in-automated-model-creation
#24
JOURNAL ARTICLE
Mostafa Rezaeitaleshmahalleh, Zonghan Lyu, Nan Mu, Jingfeng Jiang
"Image-based" computational fluid dynamics (CFD) simulations provide insights into each patient's hemodynamic environment. However, current standard procedures for creating CFD models start with manual segmentation and are time-consuming, hindering the clinical translation of image-based CFD simulations. This feasibility study adopts deep-learning-based image segmentation (hereafter referred to as Artificial Intelligence (AI) segmentation) to replace manual segmentation to accelerate CFD model creation. Two published convolutional neural network-based AI methods (MIScnn and DeepMedic) were selected to perform CFD model extraction from three-dimensional (3D) rotational angiography data containing intracranial aneurysms...
May 2023: Journal of Mechanics in Medicine and Biology
https://read.qxmd.com/read/38523366/viable-vitreous-grafts-of-whole-porcine-menisci-for-transplant-in-the-knee-and-temporomandibular-joints
#25
JOURNAL ARTICLE
Shangping Wang, Dustin Mueller, Peng Chen, Ge Pan, Marshall Wilson, Shuchun Sun, Zhenzhen Chen, Thomas Lee, Brooke Damon, R Glenn Hepfer, Cherice Hill, Michael J Kern, William M Pullen, Yongren Wu, Kelvin G M Brockbank, Hai Yao
The shortage of suitable donor meniscus grafts from the knee and temporomandibular joint (TMJ) impedes treatments for millions of patients. Vitrification offers a promising solution by transitioning these tissues into a vitreous state at cryogenic temperatures, protecting them from ice crystal damage using high concentrations of cryoprotectant agents (CPAs). However, vitrification's success is hindered for larger tissues (>3 ml) due to challenges in CPA penetration. Dense avascular meniscus tissues require extended CPA exposure for adequate penetration; however, prolonged exposure becomes cytotoxic...
March 24, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38523239/a-two-year-comparison-of-reverse-total-shoulder-arthroplasty-mini-humeral-tray-and-augmented-mini-glenoid-baseplate-implants-vs-standard-implants
#26
JOURNAL ARTICLE
Ryan Krupp, Christopher O'Grady, Brian Werner, J Michael Wiater, John Nyland, Thomas Duquin
BACKGROUND: Patients who undergo reverse total shoulder arthroplasty (RTSA) are getting younger with greater function expectations. This retrospective, longitudinal study of prospectively collected data compared perceived shoulder function and strength, active shoulder mobility, radiographic evidence of scapular notching, and implant survival over the initial 2-years post-RTSA among patient groups who received either standard central fixation point liner and glenoid baseplate implants, or lower size profile mini-humeral tray with offset trunnion options and mini-augmented glenoid baseplate implants...
March 25, 2024: Archives of Orthopaedic and Trauma Surgery
https://read.qxmd.com/read/38523011/a-modified-lateral-column-lengthening-for-the-treatment-of-flexible-flatfoot-from-clinical-applications-to-finite-element-analysis
#27
JOURNAL ARTICLE
Zhenyu Wang, Yuanqiang Li, Guo Zheng, Fangcheng Yang, Yang Liu, Yan Liang, Xingyu Xie, Xu Tao
BACKGROUND: Finite element (FE) analysis and clinical follow-up were used to evaluate the efficacy of a modified lateral column lengthening (H-LCL) for treating flexible flatfoot. METHODS: By applying inclusion and exclusion criteria, we selected patients who underwent H-LCL surgery at our institution from January 2019 to January 2023. We compared the Visual Analog Scale (VAS) scores, American Orthopaedic Foot and Ankle Society (AOFAS) scores, Pain Interference (PI), and Physical Function (PF) scores in Patient-Reported Outcomes Measurement Information System (PROMIS) between preoperative and final follow-up assessments of patients, as well as FE submodels...
March 19, 2024: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://read.qxmd.com/read/38522258/fatigue-of-the-intrinsic-foot-core-muscles-had-a-greater-effect-on-gait-than-extrinsic-foot-core-muscles-a-time-series-based-analyze
#28
JOURNAL ARTICLE
Hilal Keklicek, Halit Selcuk, Ali Yilmaz
BACKGROUND: The Heel Rise endurance (HRE) which indicates the extrinsic foot core (ECO) muscle's performance and the paper grip endurance (PGE) which indicates the intrinsic foot core (ICO) muscle's performance are essential components of a healthy foot function. However, the foot core muscles' fatigue response on spatial and temporal gait parameters after the HRE and the PGE tests were not adequately investigated. The purpose of this study was to determine whether the fatigue of the ICO and the ECO muscles affect gait parameters...
March 15, 2024: Foot
https://read.qxmd.com/read/38520934/a-numerical-study-on-the-siphonic-effect-of-enhanced-external-counterpulsation-at-lower-extremities-with-a-coupled-0d-1d-closed-loop-personalized-hemodynamics-model
#29
JOURNAL ARTICLE
Qi Zhang, Ya-Hui Zhang, Li-Ling Hao, Xuan-Hao Xu, Gui-Fu Wu, Ling Lin, Xiu-Li Xu, Lin Qi, Shuai Tian
Enhanced external counterpulsation (EECP) is a treatment and rehabilitation approach for ischemic diseases, including coronary artery disease. Its therapeutic benefits are primarily attributed to the improved blood circulation achieved through sequential mechanical compression of the lower extremities. However, despite the crucial role that hemodynamic effects in the lower extremity arteries play in determining the effectiveness of EECP treatment, most studies have focused on the diastole phase and ignored the systolic phase...
March 19, 2024: Journal of Biomechanics
https://read.qxmd.com/read/38520547/lateral-rim-variable-angle-locked-plating-versus-tension-band-wiring-of-simple-and-complex-patella-fractures-a-biomechanical-study
#30
JOURNAL ARTICLE
Stephen Warner, Christoph Sommer, Ivan Zderic, William Woodburn, Richard Castle, Jessica Penman, Eladio Saura-Sanchez, David L Helfet, Boyko Gueorguiev, Karl Stoffel
INTRODUCTION: Treatment of both simple and complex patella fractures is a challenging clinical problem. Although tension band wiring has been the standard of care, it can be associated with high complication rates. The aim of this study was to investigate the biomechanical performance of recently developed lateral rim variable angle locking plates versus tension band wiring used for fixation of simple and complex patella fractures. MATERIALS AND METHODS: Sixteen pairs of human anatomical knees were used to simulate either two-part transverse simple AO/OTA 34-C1 or five-part complex AO/OTA 34-C3 patella fractures by means of osteotomies, with each fracture model created in eight pairs...
March 23, 2024: Archives of Orthopaedic and Trauma Surgery
https://read.qxmd.com/read/38520131/mapping-the-apoe-structurally-on-missense-variants-in-elderly-brazilians
#31
JOURNAL ARTICLE
Filipe de Lima Pizzico, Rebeca Beatriz Máximo, Mario Hiroyuki Hirata, Glaucio Monteiro Ferreira
Cardiovascular diseases (CVDs) pose a significant global health threat, with familial hypercholesterolemia (FH) being a key genetic contributor. The apolipoprotein E (APOE) gene plays a vital role in lipid metabolism, and its variants are associated with CVD risk. This study explores prevalent APOE variants (p.R163C, p.R176C, p.R246C and p.V254E) using genetic and structural analyses. The research, initiated by identifying high-frequency APOE variants through the ABraOM database, utilizes homology modeling and molecular dynamics (MD) simulations to understand the structural consequences...
March 23, 2024: Journal of Biomolecular Structure & Dynamics
https://read.qxmd.com/read/38518651/the-association-between-obesity-knee-pain-and-gait-during-stair-descent-in-older-adults-with-knee-osteoarthritis
#32
JOURNAL ARTICLE
Paige E Rice, Gabriel A Pate, Ryan D Hill, Paul DeVita, Stephen P Messier
BACKGROUND: Obesity and knee osteoarthritis adversely affect activities of daily living in older adults. Together, the complexities of their interaction on mobility, including stair negotiation, are unresolved. The purpose of this study was to determine the relationship between obesity, pain, and stair negotiation in older adults with knee osteoarthritis. METHODS: Older adults with symptomatic knee osteoarthritis and overweight or obesity participated in the study (n = 28; age range = 57...
March 12, 2024: Clinical Biomechanics
https://read.qxmd.com/read/38518607/genipin-crosslinking-promotes-biomechanical-reinforcement-and-pro-regenerative-macrophage-polarization-in-bioartificial-tubular-substitutes
#33
JOURNAL ARTICLE
Jone Berasain, Paula Ávila-Fernández, Rocío Cárdenas-Pérez, Antoni Ignasi Cànaves-Llabrés, Miguel Etayo-Escanilla, Miguel Alaminos, Víctor Carriel, Óscar Darío García-García, Jesús Chato-Astrain, Fernando Campos
Traumatic nerve injuries are nowadays a significant clinical challenge and new substitutes with adequate biological and mechanical properties are in need. In this context, fibrin-agarose hydrogels (FA) have shown the possibility to generate tubular scaffolds with promising results for nerve repair. However, to be clinically viable, these scaffolds need to possess enhanced mechanical properties. In this line, genipin (GP) crosslinking has demonstrated to improve biomechanical properties with good biological properties compared to other crosslinkers...
March 20, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38518557/investigating-pelvic-drop-gait-abnormality-in-adolescent-hip-pathology-patients
#34
JOURNAL ARTICLE
Nicholas R Anable, Lauren A Luginsland, Carlos Carlos, Wilshaw R Stevens, Alex M Loewen, Kelly A Jeans, Daniel J Sucato
BACKGROUND: Trendelenburg gait describes contralateral pelvic drop during single leg stance (SLS) with occasional lateral trunk lean compensation over the stance limb. However, quantitative research on 'uncompensated Trendelenburg' gait (pelvic drop independent of lateral trunk lean) remains sparse among populations that commonly utilize this gait pattern, such as adolescent hip pathology patients. RESEARCH QUESTION: How prevalent is uncompensated Trendelenburg among various adolescent hip pathologies and how is it related to hip load, hip abduction strength, and self-reported hip pain? METHODS: Gait, strength, and pain data were collected among 152 pre-operative patients clinically diagnosed with acetabular hip dysplasia, femoroacetabular impingement, Legg-Calvé-Perthes, or slipped capital femoral epiphysis (SCFE)...
March 11, 2024: Gait & Posture
https://read.qxmd.com/read/38517552/biomechanical-analysis-of-the-human-derived-soft-tissue-graft-epiflex-for-use-in-oral-soft-tissue-augmentation
#35
JOURNAL ARTICLE
Keyvan Sagheb, Robert Noelken, Saskia-Vanessa Schröger, Christian Walter, Julian Jakob Graef, Sven Schumann
PURPOSE: This study aimed to investigate the biomechanical properties, cell migration, and revascularization of the acellular dermal matrix Epiflex. As a decellularized, freeze-dried human skin graft, Epiflex has broad applications in medical fields, particularly in implantology and dentistry. Understanding its biomechanical characteristics is crucial for its clinical adoption as a novel soft tissue graft option. METHODS: Epiflex (n = 3) was evaluated in comparison to palatal tissue from body donors (n = 3)...
March 22, 2024: International Journal of Implant Dentistry
https://read.qxmd.com/read/38516997/electric-field-induced-the-changes-in-structure-and-function-of-human-transforming-growth-factor-beta-receptor-type-i-from-molecular-dynamics-to-docking
#36
JOURNAL ARTICLE
Xinrui Jin, Xiaochuan Hu, Jiayu Chen, Lequn Shan, Dingjun Hao, Rui Zhang
The transforming growth factor beta (TGF- β ) signaling pathway is believed to play essential roles in several physiological activities, including cancer. TGF- β receptor type I (TBR-I) is a key membrane receptor protein in the TGF- β signaling pathway, which relates to many intracellular biological effects. In recent years, cold atmospheric plasma (CAP) has been found to have promising prospects in selective anticancer therapy and has confirmed its essential role in the TGF- β signaling pathway...
March 22, 2024: Journal of Biomolecular Structure & Dynamics
https://read.qxmd.com/read/38516113/displacement-and-stress-distribution-pattern-during-complete-mandibular-arch-distalization-using-buccal-shelf-bone-screws-a-three-dimensional-finite-element-study
#37
JOURNAL ARTICLE
Parul Priya, Abhay Kumar Jain, Raghu Ranjan Prasad, Shresthaa Singh, Abhishek Kumar, Priyanka Kumari
BACKGROUND: To evaluate and compare the distribution of stress and displacement of teeth during mandibular arch distalization using buccal shelf screws. MATERIALS AND METHODS: Three three-dimensional finite element models of mandibular arch were constructed with third molars extracted. Models 1, 2, and 3 were constructed on the basis of the lever arm heights of 0 mm, 3 mm, and 6 mm, respectively, between the lateral incisor and canine. A buccal shelf screw was placed at the area in the second molar region with the initial point of insertion being inter-dental between the first and second molars and 2 mm below the mucogingival junction...
2024: Journal of Orthodontic Science
https://read.qxmd.com/read/38515625/quantifying-walking-speeds-in-relation-to-ankle-biomechanics-on-a-real-time-interactive-gait-platform-a-musculoskeletal-modeling-approach-in-healthy-adults
#38
JOURNAL ARTICLE
M Peiffer, K Duquesne, M Delanghe, A Van Oevelen, S De Mits, E Audenaert, A Burssens
Background: Given the inherent variability in walking speeds encountered in day-to-day activities, understanding the corresponding alterations in ankle biomechanics would provide valuable clinical insights. Therefore, the objective of this study was to examine the influence of different walking speeds on biomechanical parameters, utilizing gait analysis and musculoskeletal modelling. Methods: Twenty healthy volunteers without any lower limb medical history were included in this study. Treadmill-assisted gait-analysis with walking speeds of 0...
2024: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/38515618/tension-band-high-strength-suture-combined-with-absorbable-cannulated-screws-for-treating-transverse-patellar-fractures-finite-element-analysis-and-clinical-study
#39
JOURNAL ARTICLE
Feifan Xiang, Yukun Xiao, Dige Li, Wenzhe Ma, Yue Chen, Yunkang Yang
Objective: Few reports exist on the treatment of transverse patellar fractures (TPFs) using absorbable cannulated screws and high-strength sutures, and most screws and sutures lack good biomechanics and clinical trials. Therefore, this study aimed to demonstrate the biomechanical stability and clinical efficacy of tension-band high-strength sutures combined with absorbable cannulated screws (TBSAS) in treating TPFs (AO/OTA 34 C1). Methods: Finite element models of five internal fixation schemes were established: tension-band wire with K-wire (TBW), TBW with cerclage wire (TBWC), TBW with headless pressure screws (TBWHS), TBW with full-thread screws (TBWFS), and TBSAS...
2024: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/38515548/twenty-years-of-blast-induced-neurotrauma-current-state-of-knowledge
#40
JOURNAL ARTICLE
Tarun Sachdeva, Shailesh G Ganpule
Blast-induced neurotrauma (BINT) is an important injury paradigm of neurotrauma research. This short communication summarizes the current knowledge of BINT. We divide the BINT research into several broad categories-blast wave generation in laboratory, biomechanics, pathology, behavioral outcomes, repetitive blast in animal models, and clinical and neuroimaging investigations in humans. Publications from 2000 to 2023 in each subdomain were considered. The analysis of the literature has brought out salient aspects...
2024: Neurotrauma reports
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