Shangping Wang, Dustin Mueller, Peng Chen, Ge Pan, Marshall Wilson, Shuchun Sun, Zhenzhen Chen, Thomas Lee, Brooke Damon, R Glenn Hepfer, Cherice Hill, Michael J Kern, William M Pullen, Yongren Wu, Kelvin G M Brockbank, Hai Yao
The shortage of suitable donor meniscus grafts from the knee and temporomandibular joint (TMJ) impedes treatments for millions of patients. Vitrification offers a promising solution by transitioning these tissues into a vitreous state at cryogenic temperatures, protecting them from ice crystal damage using high concentrations of cryoprotectant agents (CPAs). However, vitrification's success is hindered for larger tissues (>3 ml) due to challenges in CPA penetration. Dense avascular meniscus tissues require extended CPA exposure for adequate penetration; however, prolonged exposure becomes cytotoxic...
March 24, 2024: Advanced Healthcare Materials