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Oana Cristina Şeremet, Florica Bărbuceanu, Floriana Elvira Ionică, Denisa Marilena Margină, Claudia Maria GuŢu, Octavian Tudorel Olaru, Mihaela Ilie, Veaceslav Gonciar, Simona Negreş, Cornel ChiriŢă
Pyrrolizidine alkaloids (PAs) are a class of toxic compounds which are found in plants. Poisoning caused by these toxins is associated with acute and chronic liver damage. Tussilago farfara (coltsfoot), Petasites hybridus (common butterbur), Senecio vernalis (eastern groundsel) and Symphytum officinale (comfrey) are traditional phytotherapic species, which beside the therapeutic bioactive compounds contain PAs. The aim of the paper was to assess the safety of some dry extracts obtained from these species. For the determination of acute toxicity, Organization for Economic Cooperation and Development (OECD) Guideline No...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
Md Musfiqur Rahman, A M Abd El-Aty, Sung-Woo Kim, Tae-Woong Na, Ho-Chul Shin, Su-Myeong Hong, Jae-Han Shim
An effective analytical method was developed for the detection and quantification of polyoxin D in butterbur using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). Samples were extracted using acidified deionised water and purified via solid-phase extraction (SPE) using an HLB cartridge. An external matrix-matched standard calibration curve was prepared, which provided an excellent linearity with a coefficient of determination (R(2)) ⩾0.999. Limits of detection (LOD) and quantification (LOQ) were 0...
April 15, 2017: Food Chemistry
Mizue Okada, Yoshinori Okada
The aim of this study is to examine the amyloid β (Aβ) inhibition mechanism of plant sprouts' aqueous extracts (PSAE). In this study, we screened the effects of five plant sprouts' extracts on Aβ (1-42) structure modification using gel electrophoresis. In PSAE, no band of Aβ monomer was recognized in Japanese butterbur. Similarly, the Aβ monomer band became light in buckwheat, red cabbage, broccoli, and brussels. The neuroprotective effects of PSAE were evaluated by measuring levels of Aβ in mixtures (Aβ  and PSAE) with Aβ ELISA assay...
2016: Biochemistry Research International
Margaret Slavin, Julia Bourguignon, Kyle Jackson, Michael-Angelo Orciga
Calcitonin gene-related peptide (CGRP) is a pivotal messenger in the inflammatory process in migraine. Limited evidence indicates that diet impacts circulating levels of CGRP, suggesting that certain elements in the diet may influence migraine outcomes. Interruption of calcium signaling, a mechanism which can trigger CGRP release, has been suggested as one potential route by which exogenous food substances may impact CGRP secretion. The objective of this study was to investigate the effects of foods and a dietary supplement on two migraine-related mechanisms in vitro: CGRP secretion from neuroendocrine CA77 cells, and calcium uptake by differentiated PC12 cells...
July 1, 2016: Nutrients
Sita Kedia
In this article, the use of complementary and integrative medicine for the management of pediatric headache is reviewed. Despite limited numbers of studies for pediatric headaches, children and families seek these services. Integrative medicine focuses on treating the whole person, integrating conventional medicine with mind-body-spirit methods. Nutriceuticals include dietary supplements in the form of vitamins (vitamin D), minerals (magnesium), coenzyme Q, butterbur, and melatonin. Acupuncture, stimulation, physical therapy and Transcutaneous Electrical Nerve Stimulations (TENS) or Transcranial Magnetic Stimulation (TMS) may also be useful in selected patients...
February 2016: Seminars in Pediatric Neurology
Thilinie Rajapakse, Tamara Pringsheim
BACKGROUND: The use of nutraceuticals or food/herbal products for health benefits is expanding in adults with migraine as they seek relief from pain in an effective and tolerable manner not always afforded by current conventional pharmacologic therapies. Guidelines from the American Academy of Neurology/American Headache Society, Canadian Headache Society, and European Federation of Neurological Societies have discussed nutraceuticals in varying degrees of detail with at times conflicting recommendations...
April 2016: Headache
Young-Whan Choi, Kyoung-Pil Lee, Jung-Min Kim, Saeromi Kang, Soo-Jin Park, Jung-Min Lee, Hyung Ryong Moon, Jee H Jung, Young-Geun Lee, Dong-Soon Im
ETHNOPHARMACOLOGICAL RELEVANCE: The giant butterbur Petasites japonicus is used to treat asthma and allergic diseases in traditional Korean, Japanese, and Chinese medicine. AIM OF THE STUDY: To elucidate the anti-allergic effect of Petasites genus, we studied effects of several compounds from Petasites japonicus leaves and found a novel bakkenolide-type sesquiterpine. In the present study, anti-allergic and anti-inflammatory effects of the new compound was examined using in vivo and in vitro experiments...
February 3, 2016: Journal of Ethnopharmacology
Kam L Hon, Ching K Fung, Alexander K C Leung, Hung S Lam, So L Lee
Allergic rhinitis (AR) is a common respiratory disease affecting both adults and children worldwide. Affected patients may experience nasal congestion/stuffiness, rhinorrhea (anterior and/or posterior), nasal/ nasopharyngeal itching and sneezing. Allergen avoidance is the principal step in the management. Nasal saline irrigation to remove allergen (s) in the nose is a useful adjunctive therapy in the management of moderate to severe AR. Symptomatic relief and improved quality of life may be achieved in the majority of patients with appropriate pharmacotherapy...
2015: Recent Patents on Inflammation & Allergy Drug Discovery
Stephen D Silberstein
PURPOSE OF REVIEW: This article reviews the evidence base for the preventive treatment of migraine. RECENT FINDINGS: Evidence-based guidelines for the preventive treatment of migraine have recently been published by the American Academy of Neurology (AAN) and the Canadian Headache Society (CHS), providing valuable guidance for clinicians. Strong evidence exists to support the use of metoprolol, timolol, propranolol, divalproex sodium, sodium valproate, and topiramate for migraine prevention, according to the AAN...
August 2015: Continuum: Lifelong Learning in Neurology
Hyun Jung Kim, Song Yi Park, Hye Min Lee, Dong Ik Seo, Young-Min Kim
Traditional medicinal plants have been used in the treatment of various diseases for centuries. A number of plant-derived compounds have been proposed as anticancer agents and are currently undergoing medical development. Petasites japonicus (PJ), also known as Butterbur, is a herb cultivated in East Asia that is used as a traditional herbal medicine. The aim of the present study was to investigate whether a methanol extract of PJ demonstrated anticancer activity against Hep3B hepatocellular carcinoma (HCC) cells...
May 2015: Experimental and Therapeutic Medicine
Kyoung-Pil Lee, Saeromi Kang, Min-Soo Noh, Soo-Jin Park, Jung-Min Kim, Hae Young Chung, Nam Kyung Je, Young-Geun Lee, Young-Whan Choi, Dong-Soon Im
To explore the anti-allergic and anti-inflammatory effects of extracts of Petasites genus, we studied the effects of s-petasin, a major sesquiterpene from Petasites formosanus (a butterbur species) on asthma and peritonitis models. In an ovalbumin-induced mouse asthma model, s-petasin significantly inhibited the accumulations of eosinophils, macrophages, and lymphocytes in bronchoalveolar fluids. S-petasin inhibited the antigen-induced degranulation of β-hexosamidase but did not inhibit intracellular Ca(2+) increase in RBL-2H3 mast cells...
January 2015: Biomolecules & Therapeutics
Keiko Tagami, Shigeo Uchida
Concentrations of (137)Cs and (40)K in different tissues of edible wild herbaceous plants, that is, leaf blade and petiole for giant butterbur (Petasites japonicas (Siebold et Zucc.) Maxim.), and leaf, stem and strobilus for fertile shoot of field horsetail (Equisetum arvense L.) were measured in 2012-2014 to clarify the effect in Japan from the Fukushima Daiichi Nuclear Power Plant accident. The concentrations of (137)Cs decreased with time with effective half-lives of ca. 450 d and 360 d for giant butterbur and field horsetail, respectively...
March 2015: Journal of Environmental Radioactivity
Eun-Ju Yang, Geum-Soog Kim, Mira Jun, Kyung-Sik Song
It is thought that the neuronal cell loss caused by oxidative stress is the primary mechanism underlying the pathogenesis of several neurodegenerative disorders. Glutamate is an endogenous neurotransmitter, but at high concentrations it can act as a neurotoxicant by increasing the intracellular levels of reactive oxygen species (ROS). Therefore, the development of factors that can attenuate glutamate-induced oxidative stress in neuronal cells is a good strategy by which new drugs could be discovered that may treat or prevent neurodegenerative diseases...
July 25, 2014: Food & Function
Serena L Orr, Sunita Venkateswaran
INTRODUCTION: The literature on complementary and alternative medicine (CAM) is expanding. One of the most common conditions for which CAM is studied in the pediatric population is migraine. Nutraceuticals are a form of CAM that is being used for pediatric migraine prophylaxis. METHODS: A literature search was carried out in order to identify both observational studies and randomized controlled trials on the use of nutraceuticals for the prophylaxis of pediatric migraine...
July 2014: Cephalalgia: An International Journal of Headache
Gretchann Utterback, Rayna Zacharias, Shahrazad Timraz, Denay Mershman
The incidence of migraine headaches in childhood is increasing. Migraines are often difficult to diagnose in pediatrics and even more difficult to treat and prevent. In order to decrease the impact of the condition on the child and the family, prophylactic treatment is recommended if the child is experiencing disabling migraines. The medications currently prescribed for the prevention of pediatric migraines often have significant side effects and are of questionable therapeutic value. For those patients and parents who are interested in alternative therapies and natural remedies for preventive treatment of pediatric migraines, butterbur extract derived from the butterbur plant, Petasites hybridus, has emerged as a promising treatment...
February 2014: Complementary Therapies in Clinical Practice
Ahmet Alper Aydın, Thomas Letzel
With the worldwide rapid increasing interest in the use of natural products as dietary supplements, medical remedies and functional foods, it has been accepted that omitting the plant constituents with potential adverse effects was a huge fault of the past. Several countries developed regulations to limit the consumption of such products in the markets. Among these natural products, butterbur (Petasites) has been used for years as herbal supplement for its anti-spasmodic and anti-inflammatory effects. However, its hepatotoxic alkaloid content limits the direct usage...
November 2013: Journal of Pharmaceutical and Biomedical Analysis
Nils Baumann, Thuro Arnold, Götz Haferburg
Uranium concentrations in cultivated (sunflower, sunchoke, potato) and native plants, plant compartment specimens, and mushrooms, grown on a test site within a uranium-contaminated area in Eastern Thuringia, were analyzed and compared. This test site belongs to the Friedrich-Schiller University Jena and is situated on the ground of a former but now removed uranium mine waste leaching heap. For determination of the U concentrations in the biomaterials, the saps of the samples were squeezed out by using an ultracentrifuge, after that, the uranium concentrations in the saps and the remaining residue were measured, using ICP-MS...
2014: Environmental Science and Pollution Research International
Ahmet Alper Aydın, Valentin Zerbes, Harun Parlar, Thomas Letzel
Butterbur (Petasites) is an ancient plant which has been used for medical and edible purposes with its spasmolytic agents. However, toxic alkaloid content of the plant limits its direct usage. The paper covers the pyrrolizidine alkaloids (PAs) and butterbur themes in detail in order to display the outline of alkaloid-free plant extract production for medical and edible purposes. The toxic PAs and medicinal constituents of the plant are described with emphasis on analytics, physiological effects and published patent data on alkaloid free extract production...
March 5, 2013: Journal of Pharmaceutical and Biomedical Analysis
Sung-Jin Kim, Sea C Min, Hyo-Jin Shin, Yun-Jeong Lee, Ah Reum Cho, So Yeon Kim, Jaejoon Han
In this study, we assessed the antioxidant efficacy and nutritional value of 10 leafy edible plants and evaluated their potential as natural antioxidants for meat preservation. We measured total phenolic content, 2,2-diphenyl-1-picryl-hydrazil (DPPH) radical scavenging activity, and vitamin C, chlorophyll, and carotenoid contents of 70% ethanol and water extracts of the edible plants. Based on these results, we investigated the effects of butterbur and broccoli extracts on lipid oxidation in ground beef patties...
March 2013: Meat Science
Kyu-Ho Han, Mitsuo Sekikawa, Ken-Ichiro Shimada, Chi-Ho Lee, Naoto Hashimoto, Michihiro Fukushima
We investigated the adverse effects of Japanese butterbur leaves (Petasites japonicus, Compositae) in male F344/DuCrj rats. The rats were fed a control diet or a treatment diet containing 5% butterbur leaf powder for 4 weeks. No differences were observed in body weight gain, food intake or feed efficiency between treatments, but relative liver weight in the butterbur group was significantly higher than that of the control group. In addition, thiobarbituric acid reactive substances (TBARs) and glutathione levels in the serum and liver of the butterbur group were higher than those of the control group...
2012: Bioscience, Biotechnology, and Biochemistry
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