keyword
MENU ▼
Read by QxMD icon Read
search

EMRA

keyword
https://www.readbyqxmd.com/read/27891189/variations-in-dna-methylation-of-interferon-gamma-and-programmed-death-1-in-allograft-rejection-after-kidney-transplantation
#1
Karin Boer, L Elly A de Wit, Fleur S Peters, Dennis A Hesselink, Leo J Hofland, Michiel G H Betjes, Caspar W N Looman, Carla C Baan
BACKGROUND: The role of DNA methylation in the regulation of the anti-donor-directed immune response after organ transplantation is unknown. Here, we studied the methylation of two mediators of the immune response: the pro-inflammatory cytokine interferon γ (IFNγ) and the inhibitory receptor programmed death 1 (PD1) in naïve and memory CD8+ T cell subsets in kidney transplant recipients receiving immunosuppressive medication. Both recipients experiencing an episode of acute allograft rejection (rejectors) as well as recipients without rejection (non-rejectors) were included...
2016: Clinical Epigenetics
https://www.readbyqxmd.com/read/27884783/secondary-multidrug-efflux-pump-mutants-alter-escherichia-coli-biofilm-growth-in-the-presence-of-cationic-antimicrobial-compounds
#2
Denice C Bay, Carol A Stremick, Carmine J Slipski, Raymond J Turner
Escherichia coli possesses many secondary active multidrug resistance transporters (MDTs) that confer overlapping substrate resistance to a broad range of antimicrobials via proton and/or sodium motive force. It is uncertain whether redundant MDTs uniquely alter cell survival when cultures grow planktonically or as biofilms. In this study, the planktonic and biofilm growth and antimicrobial resistance of 13 E. coli K-12 single MDT gene deletion strains in minimal and rich media were determined. Antimicrobial tolerance to tetracycline, tobramycin and benzalkonium were also compared for each ΔMDT strain...
November 22, 2016: Research in Microbiology
https://www.readbyqxmd.com/read/27859987/evolution-of-the-model-of-the-clinical-practice-of-emergency-medicine-1979-to-present
#3
Francis L Counselman, Michael S Beeson, Catherine A Marco, Susan K Adsit, Anne L Harvey, Julia N Keehbauch
The Model of the Clinical Practice of Emergency Medicine (The EM Model) is a three dimensional representation of the clinical practice of Emergency Medicine. It is a product of successful collaboration involving the American Board of Emergency Medicine (ABEM), the American College of Emergency Physicians (ACEP), the Society for Academic Emergency Medicine (SAEM), the Emergency Medicine Residents' Association (EMRA), the Council of Emergency Medicine Residency Directors (CORD), the Residency Review Committee for Emergency Medicine (RRC-EM) and the American Academy of Emergency Medicine (AAEM)...
November 17, 2016: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/27835840/correlation-between-the-number-of-pro-ala-repeats-in-the-emra-homologue-of-acinetobacter-baumannii-and-resistance-to-netilmicin-tobramycin-imipenem-and-ceftazidime
#4
Alicja Nowak-Zaleska, Miłosz Wieczór, Jacek Czub, Łukasz Nierzwicki, Roman Kotłowski, Agnieszka Mikucka, Eugenia Gospodarek
Acinetobacter baumannii coccobacilli are dangerous to patients in intensive care units because of their multidrug resistance to antibiotics, developed mainly in the past decade. This study aimed to examine whether there is a significant correlation between the number of Pro-Ala repeats in the CAP01997 protein, the EmrA homologue of A. baumannii, and resistance to antibiotics. A total of 79 multidrug-resistant A. baumannii strains isolated from patients were analysed. Resistance to antibiotics was determined on Mueller-Hinton agar plates using the Kirby-Bauer disk diffusion method...
December 2016: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/27793830/benzoate-and-salicylate-tolerant-strains-lose-antibiotic-resistance-during-laboratory-evolution-of-escherichia-coli-k-12
#5
Kaitlin E Creamer, Frederick S Ditmars, Preston J Basting, Karina S Kunka, Issam N Hamdallah, Sean P Bush, Zachary Scott, Amanda He, Stephanie R Penix, Alexandra S Gonzales, Elizabeth K Eder, Dominic Camperchioli, Adama Berndt, Michelle W Clark, Kerry A Rouhier, Joan L Slonczewski
: Escherichia coli K-12 W3110 grows in the presence of membrane-permeant organic acids that can depress cytoplasmic pH and accumulate in the cytoplasm. We conducted experimental evolution by daily diluting cultures in increasing concentrations of benzoic acid (up to 20 mM) buffered at external pH 6.5, a pH at which permeant acids concentrate in the cytoplasm. By 2,000 generations, clones isolated from evolving populations showed increasing tolerance to benzoate but were sensitive to chloramphenicol and tetracycline...
October 28, 2016: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/27722066/multidrug-resistance-operon-emrab-contributes-for-chromate-and-ampicillin-co-resistance-in-a-staphylococcus-strain-isolated-from-refinery-polluted-river-bank
#6
He Zhang, Yantian Ma, Pu Liu, Xiangkai Li
EmrAB operon is known for multidrug resistance in bacteria and yet has not been reported related to heavy metal resistance or antibiotics/heavy metal co-resistance. Strain Staphylococcus aureus LZ-01 which was isolated from industrial wastewater discharging site can co-resist to 6 mM Cr(VI) and 0.75 mg/ml ampicillin. Transcriptome data showed that an emrAB operon was upregulated (1.29-folds for emrA, 2.14-folds for emrB) under 0.4 mM Cr(VI) treatment. Quantitative PCR results revealed that this operon was upregulated (1...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27383751/a-study-of-artificial-eyes-for-the-measurement-of-precision-in-eye-trackers
#7
Dong Wang, Fiona B Mulvey, Jeff B Pelz, Kenneth Holmqvist
The precision of an eye-tracker is critical to the correct identification of eye movements and their properties. To measure a system's precision, artificial eyes (AEs) are often used, to exclude eye movements influencing the measurements. A possible issue, however, is that it is virtually impossible to construct AEs with sufficient complexity to fully represent the human eye. To examine the consequences of this limitation, we tested currently used AEs from three manufacturers of eye-trackers and compared them to a more complex model, using 12 commercial eye-trackers...
July 6, 2016: Behavior Research Methods
https://www.readbyqxmd.com/read/27378225/prevention-strategies-differentially-modulate-the-impact-of-cytomegalovirus-replication-on-cd8-t-cell-differentiation-in-high-risk-solid-organ-transplant-patients
#8
Sara Cantisán, Aurora Páez-Vega, Pilar Pérez-Romero, Miguel Montejo, Elisa Cordero, Irene Gracia-Ahufinger, Cecilia Martín-Gandul, Naroa Maruri, Rocío Aguado, Rafael Solana, Julián Torre-Cisneros
The present study aimed to determine whether antiviral prevention strategies against cytomegalovirus (CMV) infection used in high-risk D+R- solid organ transplanted patients can modulate the impact of CMV replication on CD8(+) T-cell differentiation. The different CD8(+) T-cell subpopulations were measured at a single point when at least one year had elapsed since transplantation. A total of 68 D+R- patients were included, of which 33 underwent pre-emptive therapy and 35 received prophylaxis. Multivariate analysis showed that CMV replication was associated with the expansion of CD28־ EMRA CD8(+) T cells in patients managed pre-emptively but not in patients under prophylaxis (21...
August 2016: Antiviral Research
https://www.readbyqxmd.com/read/27267160/mid-range-atmospheric-dispersion-modelling-intercomparison-of-simple-models-in-emras-2-project
#9
Raúl Periáñez, Kathleen M Thiessen, Sohan L Chouhan, Francesco Mancini, Emilie Navarro, Gert Sdouz, Dejan Trifunović
An intercomparison of atmospheric dispersion models has been carried out for a hypothetical accident occurring in a nuclear power plant in the center of Spain. The accident consisted of a steam generator tube rupture, and two radionuclides have been considered for the exercise: 137-Cs and 131-I. Meteorological conditions and radionuclide release rates were supplied. Models provided deposition maps, timeintegrated concentrations in air and arrival times of the plumes to specific locations. The effect of the meteorological conditions used in the modelling was clear, with different behavior of the plume with neutral stability vs...
June 4, 2016: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/26963521/stability-of-ensemble-models-predicts-productivity-of-enzymatic-systems
#10
Matthew K Theisen, Jimmy G Lafontaine Rivera, James C Liao
Stability in a metabolic system may not be obtained if incorrect amounts of enzymes are used. Without stability, some metabolites may accumulate or deplete leading to the irreversible loss of the desired operating point. Even if initial enzyme amounts achieve a stable steady state, changes in enzyme amount due to stochastic variations or environmental changes may move the system to the unstable region and lose the steady-state or quasi-steady-state flux. This situation is distinct from the phenomenon characterized by typical sensitivity analysis, which focuses on the smooth change before loss of stability...
March 2016: PLoS Computational Biology
https://www.readbyqxmd.com/read/26918560/intensive-exercise-does-not-preferentially-mobilize-skin-homing-t-cells-and-nk-cells
#11
James E Turner, Alex J Wadley, Sarah Aldred, James P Fisher, Jos A Bosch, John P Campbell
PURPOSE: This study investigated whether natural killer (NK) cells and CD8+ T cells expressing cutaneous lymphocyte antigen (CLA)-a homing molecule for endothelial cell leukocyte adhesion molecule 1, which enables transmigration to the skin-are selectively mobilized in response to acute exercise. METHODS: Nine healthy men (mean ± SD age: 22.1 ± 3.4 yr) completed two exercise sessions: high-intensity continuous cycling ("continuous exercise" at 80% V˙O2max for 20 min) and low-volume high-intensity interval exercise (at 90% V˙O2max 10 × 1 min repetitions with 1 min recovery intervals)...
July 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/26881265/a-preliminary-comparative-assessment-of-the-role-of-cd8-t-cells-in-chronic-fatigue-syndrome-myalgic-encephalomyelitis-and-multiple-sclerosis
#12
Ekua W Brenu, Simon Broadley, Thao Nguyen, Samantha Johnston, Sandra Ramos, Don Staines, Sonya Marshall-Gradisnik
Background. CD8+ T cells have putative roles in the regulation of adaptive immune responses during infection. The purpose of this paper is to compare the status of CD8+ T cells in Multiple Sclerosis (MS) and Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME). Methods. This preliminary investigation comprised 23 CFS/ME patients, 11 untreated MS patients, and 30 nonfatigued controls. Whole blood samples were collected from participants, stained with monoclonal antibodies, and analysed on the flow cytometer...
2016: Journal of Immunology Research
https://www.readbyqxmd.com/read/26725066/assessment-of-gastric-emptying-in-patients-with-autoimmune-gastritis
#13
Çağdaş Kalkan, Irfan Soykan, Çiğdem Soydal, Elgin Özkan, Emra Kalkan
BACKGROUND AND AIM: Symptoms of patients with autoimmune gastritis are not specific, and some patients may present symptoms suggestive of delayed gastric emptying. This study aims to investigate whether any delay in gastric emptying of solid food exists in patients with autoimmune gastritis and, if so, to identify the factors that might affect delayed gastric emptying. METHODS: A total of 165 patients (106 women) diagnosed as having autoimmune gastritis were analyzed by means of a gastric emptying test...
June 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/26290049/elevated-hba-1c-levels-and-the-accumulation-of-differentiated-t-cells-in-cmv-individuals
#14
Jerrald L Rector, G Neil Thomas, Victoria E Burns, Jennifer B Dowd, Raphael M Herr, Paul A Moss, Marc N Jarczok, Kristina Hoffman, Joachim E Fischer, Jos A Bosch
AIMS/HYPOTHESIS: Biological ageing of the immune system, or immunosenescence, predicts poor health and increased mortality. A hallmark of immunosenescence is the accumulation of differentiated cytotoxic T cells (CD27(-)CD45RA(+/-); or dCTLs), partially driven by infection with the cytomegalovirus (CMV). Immune impairments reminiscent of immunosenescence are also observed in hyperglycaemia, and in vitro studies have illustrated mechanisms by which elevated glucose can lead to increased dCTLs...
November 2015: Diabetologia
https://www.readbyqxmd.com/read/26151657/modelling-and-assessment-of-the-impact-of-radiocesium-and-radiostrontium-contamination-in-the-thermaikos-gulf-greece
#15
G Eleftheriou, L Monte, J E Brittain, C Tsabaris
A radiological model for (137)Cs and (90)Sr dispersion in the marine environment of the Thermaikos Gulf, Greece, and the river catchments draining into the Gulf, is presented. The model, developed and implemented within the MOIRA-PLUS decision support system, integrates appropriate site-specific information. The model's performance has been tested using the available empirical (137)Cs activity concentration data in abiotic and biotic components of the gulf since the Chernobyl accident. Further, this paper describes the results of a modelling exercise performed within the IAEA's EMRAS II international modelling programme to estimate the environmental sensitivity of this characteristic Mediterranean coastal marine environment following radioactive contamination...
November 15, 2015: Science of the Total Environment
https://www.readbyqxmd.com/read/26055688/distribution-of-different-efflux-pump-genes-in-clinical-isolates-of-multidrug-resistant-acinetobacter-baumannii-and-their-correlation-with-antimicrobial-resistance
#16
Ming-Feng Lin, Yun-You Lin, Chi-Chao Tu, Chung-Yu Lan
BACKGROUND/PURPOSE: Efflux pumps are one of the major mechanisms of antimicrobial resistance in Acinetobacter baumannii. This study aimed to understand the distribution of different types of pump genes in clinical isolates of multidrug-resistant A. baumannii (MDRAB) and to reveal the relationship between their presence and expression with antimicrobial resistance. METHODS: MDRAB isolates were collected from five hospitals in Taiwan. Different categories of pump genes, including adeB, adeJ, macB, abeM, abeS, emrA-like, emrB-like, and craA, were chosen, and their presence in the collected isolates was determined...
May 14, 2015: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/25707450/blockade-of-pd-1-or-p38-map-kinase-signaling-enhances-senescent-human-cd8-t-cell-proliferation-by-distinct-pathways
#17
Sian M Henson, Richard Macaulay, Natalie E Riddell, Craig J Nunn, Arne N Akbar
Immune enhancement is desirable in situations where decreased immunity results in increased morbidity. We investigated whether blocking the surface inhibitory receptor PD-1 and/or p38 MAP kinase could enhance the proliferation of the effector memory CD8(+) T-cell subset that re-expresses CD45RA (EMRA) and exhibits characteristics of senescence, which include decreased proliferation and telomerase activity but increased expression of the DNA damage response related protein γH2AX. Blocking of both PD-1 and p38 MAPK signaling in these cells enhanced proliferation and the increase was additive when both pathways were inhibited simultaneously in both young and old human subjects...
May 2015: European Journal of Immunology
https://www.readbyqxmd.com/read/25463715/predicting-exposure-of-wildlife-in-radionuclide-contaminated-wetland-ecosystems
#18
K Stark, P Andersson, N A Beresford, T L Yankovich, M D Wood, M P Johansen, J Vives i Batlle, J Twining, D-K Keum, A Bollhöfer, C Doering, B Ryan, M Grzechnik, H Vandenhove
Many wetlands support high biodiversity and are protected sites, but some are contaminated with radionuclides from routine or accidental releases from nuclear facilities. This radiation exposure needs to be assessed to demonstrate radiological protection of the environment. Existing biota dose models cover generic terrestrial, freshwater, and marine ecosystems, not wetlands specifically. This paper, which was produced under IAEA's Environmental Modelling for Radiation Safety (EMRAS) II programme, describes an evaluation of how models can be applied to radionuclide contaminated wetlands...
January 2015: Environmental Pollution
https://www.readbyqxmd.com/read/25278812/cd28-cd45ra-null-dim-and-natural-killer-like-cd8-t-cells-are-increased-in-peripheral-blood-of-women-with-low-grade-cervical-lesions
#19
Maria Luisa Pita-Lopez, Pablo Cesar Ortiz-Lazareno, Monica Navarro-Meza, Felipe Santoyo-Telles, Oscar Peralta-Zaragoza
BACKGROUND: In response to antigen naive CD8+, T cells differentiate into effector cells, which express Natural killer (NK) receptors, lose CD28 expression, and die by apoptosis. However, in smaller quantities, the cells are retained for subsequent exposure to the same antigen. Knowledge is limited regarding whether the percentages of CD28-, Effector memory (EMRA(null/dim)), and the CD16+/CD56 + CD8+ T cells of women with low-grade cervical lesions are altered at a systemic level...
2014: Cancer Cell International
https://www.readbyqxmd.com/read/25040348/the-multifaceted-roles-of-the-interspecies-signalling-molecule-indole-in-agrobacterium-tumefaciens
#20
Jin-Hyung Lee, Yong-Guy Kim, Kwang-Hyun Baek, Moo Hwan Cho, Jintae Lee
Bacteria utilize signal molecules to ensure their survival in environmental niches, and indole is an interspecies and interkingdom signalling molecule, which is widespread in the natural environment. In this study, we sought to identify novel roles of indole in soil-borne bacterium Agrobacterium tumefaciens. Agrobacterium tumefaciens was found not to synthesize indole and to degrade it rapidly. The addition of exogenous indole dose-dependently inhibited A. tumefaciens growth and decreased its motility. Surprisingly, indole markedly increased A...
April 2015: Environmental Microbiology
keyword
keyword
58561
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"