Xiao Huang, Huihui Bao, Congcong Ding, Junpei Li, Tianyu Cao, Lishun Liu, Yaping Wei, Ziyi Zhou, Nan Zhang, Yun Song, Ping Chen, Chongfei Jiang, Liling Xie, Xianhui Qin, Yan Zhang, Jianping Li, Ningling Sun, Genfu Tang, Xiaobin Wang, Hong Wang, Yong Huo, Xiaoshu Cheng
BACKGROUND: While folic acid (FA) is widely used to treat elevated total homocysteine (tHcy), promoting vascular health by reducing vascular oxidative stress and modulating endothelial nitric oxide synthase, the optimal daily dose and individual variation by MTHFR C677T genotypes have not been well studied. Therefore, this study aimed to explore the efficacy of eight different FA dosages on tHcy lowering in the overall sample and by MTHFR C677T genotypes. METHODS: This multicentered, randomized, double-blind, controlled clinical trial included 2697 eligible hypertensive adults with elevated tHcy (≥ 10 mmol/L) and without history of stroke and cardiovascular disease...
March 13, 2024: European Journal of Nutrition