keyword
https://read.qxmd.com/read/38502191/editorial-expression-of-concern-maternal-serum-homocysteine-and-uterine-artery-doppler-as-predictors-of-preeclampsia-and-poor-placentation
#21
Ahmed M Maged, Hany Saad, Hadeer Meshaal, Emad Salah, Suzy Abdelaziz, Eman Omran, Wesam S Deeb, Maha Katta
No abstract text is available yet for this article.
March 19, 2024: Archives of Gynecology and Obstetrics
https://read.qxmd.com/read/38501537/homocysteine-potentiated-kelch-like-ech-associated-protein-1-promotes-senescence-of-neuroblastoma-2a-cells-via-inhibiting-ubiquitination-of-%C3%AE-catenin
#22
JOURNAL ARTICLE
Yao Zhang, Jia-Zhao Xie, Yan-Li Jiang, Shao-Juan Yang, Hui Wei, Ying Yang, Jian-Zhi Wang
Elevated serum homocysteine (Hcy) level is a risk factor for Alzheimer's disease (AD) and accelerates cell aging. However, the mechanism by which Hcy induces neuronal senescence remains largely unknown. In this study, we observed that Hcy significantly promoted senescence in neuroblastoma 2a (N2a) cells with elevated β-catenin and Kelch-like ECH-associated protein 1 (KEAP1) levels. Intriguingly, Hcy promoted the interaction between KEAP1 and the Wilms tumor gene on the X chromosome (WTX) while hampering the β-catenin-WTX interaction...
March 19, 2024: European Journal of Neuroscience
https://read.qxmd.com/read/38501284/gene-expression-profiling-of-peripheral-blood-in-patients-with-steroid-induced-osteonecrosis-of-the-femoral-head
#23
JOURNAL ARTICLE
Cong-Min Zhang, Yuan Wei, Xue-Ke Tian, Kai-Di Ren, Jing Yang
Aim: Steroid-induced osteonecrosis of the femoral head (SONFH) is a severe complication following glucocorticoid therapy. This study aimed to identify the differential mRNA expression and investigate the molecular mechanisms of SONFH. Materials & methods: RNA sequencing was performed in eight SONFH patients, five non-SONFH patients and five healthy individuals. Results: A total of 1555, 3997 and 5276 differentially expressed mRNAs existed between the following combinations: SONFH versus non-SONFH, SONFH versus healthy subjects and non-SONFH versus healthy subjects...
March 19, 2024: Personalized Medicine
https://read.qxmd.com/read/38500044/whole-genome-identification-molecular-docking-and-expression-analysis-of-enzymes-involved-in-the-selenomethionine-cycle-in-cardamine-hupingshanensis
#24
JOURNAL ARTICLE
Xixi Zeng, Guoqiang Luo, Zhucheng Fan, Zhijing Xiao, Yanke Lu, Qiang Xiao, Zhi Hou, Qiaoyu Tang, Yifeng Zhou
BACKGROUND: The selenomethionine cycle (SeMTC) is a crucial pathway for the metabolism of selenium. The basic bioinformatics and functions of four enzymes involved in the cycle including S-adenosyl-methionine synthase (MAT), SAM-dependent methyltransferase (MTase), S-adenosyl-homocysteine hydrolase (SAHH) and methionine synthase (MTR), have been extensively reported in many eukaryotes. The identification and functional analyses of SeMTC genes/proteins in Cardamine hupingshanensis and their response to selenium stress have not yet been reported...
March 19, 2024: BMC Plant Biology
https://read.qxmd.com/read/38499954/the-differences-between-carotid-web-and-carotid-web-with-plaque-based-on-multimodal-ultrasonic-and-clinical-characteristics
#25
JOURNAL ARTICLE
Chao Hou, Shuo Li, Lei Zhang, Wei Zhang, Wen He
OBJECTIVE: This study aimed to examine the clinical and multimodal ultrasonic characteristics differences between carotid web (CW) and CW with plaque as well as the potential risk factors for stroke caused by CW. METHODS: We retrospectively enrolled patients diagnosed with CW by CTA or high-resolution MRI (HRMRI) and simultaneously underwent contrast enhanced ultrasound (CEUS) and superb microvascular imaging examinations from January 2015 to October 2022. The CW angle was measured using computer-aided software...
March 18, 2024: Insights Into Imaging
https://read.qxmd.com/read/38498948/simultaneous-sers-sensing-of-cysteine-and-homocysteine-in-blood-based-on-the-cbt-cys-click-reaction-toward-precisive-diagnosis-of-schizophrenia
#26
JOURNAL ARTICLE
Biao Zhang, Jun Cao, Si-Jie Liao, Peng-Cheng Zhou, Yu-Ting Shen, Wei Yu, Wei Li, Ai-Guo Shen
At present, there is a lack of sufficiently specific laboratory diagnostic indicators for schizophrenia. Serum homocysteine (Hcy) levels have been found to be related to schizophrenia. Cysteine (Cys) is a demethylation product in the metabolism of Hcy, and they always coexist with highly similar structures in vivo . There are few reports on the use of Cys as a diagnostic biomarker for schizophrenia in collaboration with Hcy, mainly because the rapid, economical, accurate, and high-throughput simultaneous detection of Cys and Hcy in serum is highly challenging...
March 18, 2024: Analytical Chemistry
https://read.qxmd.com/read/38498335/genome-wide-identification-of-hmt-gene-family-explores-bphmt2-enhancing-the-selenium-accumulation-and-tolerance-in-broussonetia-papyrifera
#27
JOURNAL ARTICLE
Qiangwen Chen, Changye Zhu, Longfei Guo, Xianchen Bu, Wei Yang, Shuiyuan Cheng, Xin Cong, Feng Xu
Broussonetia papyrifera, a valuable feed resource, is known for its fast growth, wide adaptability, high protein content, and strong selenium enrichment capacity. Selenomethionine (SeMet), the main selenium form in selenium fortification B. papyrifera, is safe for animals and enhances its nutritional value as a feed resource. However, the molecular mechanisms underlying SeMet synthesis remain unclear. This study identified three homocysteine S-methyltransferase genes from B. papyrifera genome. The phylogenetic tree demonstrated that BpHMTs were divided into two classes, and BpHMT2 in the Class 2-D subfamily evolved earlier and possesses more fundamental functions...
March 18, 2024: Tree Physiology
https://read.qxmd.com/read/38497013/python-based-algorithm-for-estimating-the-parameters-of-physical-property-models-for-substances-not-available-in-database
#28
JOURNAL ARTICLE
Jina Lee, Wangyun Won, Jun-Woo Kim
An in-house Python-based algorithm was developed using simplified molecular-input line-entry specification (SMILES) strings and a dipole moment for estimating the normal boiling point, critical properties, standard enthalpy, vapor pressure, liquid molar volume, enthalpy of vaporization, heat capacity, viscosity, thermal conductivity, and surface tension of molecules. Normal boiling point, critical properties, and standard enthalpy were estimated by using the Joback group contribution method. Vapor pressure, liquid molar volume, enthalpy of vaporization, heat capacity, and surface tension were estimated by using the Riedel model, Gunn-Yamada model, Clausius-Clapeyron equation, Joback group contribution method, and Brock-Bird model, respectively...
March 12, 2024: ACS Omega
https://read.qxmd.com/read/38486257/plasma-metabolomic-profile-in-orthostatic-intolerance-children-with-high-levels-of-plasma-homocysteine
#29
JOURNAL ARTICLE
Yaqi Li, Baoling Bai, Hui Wang, Haojie Wu, Yanjun Deng, Chen Shen, Qin Zhang, Lin Shi
BACKGROUND: Orthostatic intolerance, which includes vasovagal syncope and postural orthostatic tachycardia syndrome, is common in children and adolescents. Elevated plasma homocysteine levels might participate in the pathogenesis of orthostatic intolerance. This study was designed to analyze the plasma metabolomic profile in orthostatic intolerance children with high levels of plasma homocysteine. METHODS: Plasma samples from 34 orthostatic intolerance children with a plasma homocysteine concentration > 9 µmol/L and 10 healthy children were subjected to ultra-high-pressure liquid chromatography and quadrupole-time-of-flight mass spectrometry analysis...
March 14, 2024: Italian Journal of Pediatrics
https://read.qxmd.com/read/38484708/conquering-homocystinuria-with-engineered-probiotics
#30
JOURNAL ARTICLE
Skye R S Fishbein, Esse M Evbuomwan, Gautam Dantas
Pyridoxine-unresponsive homocystinuria has lifelong implications for health. In this issue, Perreault and colleagues present evidence that orally delivered engineered probiotic Escherichia Coli Nissle SYNB1353 is a promising candidate in reducing homocysteine, with successful trials in mice, monkeys, and humans. However, further probiotic optimization and safety assessments are required.
March 13, 2024: Cell Host & Microbe
https://read.qxmd.com/read/38484315/effect-of-yoga-in-industrial-workers-with-chronic-venous-insufficiency-a-randomized-controlled-trial
#31
JOURNAL ARTICLE
U Yamuna, B Pravalika, Kshamashree Madle, Vijaya Majumdar, Apar Avinash Saoji
Background and objective: Prolonged standing is one of the significant contributors to chronic venous insufficiency (CVI) in industry workers. Yoga is proven to be an effective therapy in treating occupational hazards. The current study aimed to investigate the effect of yoga on CVI among industry workers. Methodology: Male workers ( n  = 100) from machinery manufacturing industries in Bangalore meeting the inclusion and exclusion criteria were recruited for the study. The yoga group received a specifically designed yoga module for 6 days a week for 12 weeks, and the control group was offered lifestyle suggestions...
March 14, 2024: J Integr Complement Med
https://read.qxmd.com/read/38483185/parental-betaine-supplementation-promotes-gosling-growth-with-epigenetic-modulation-of-igf-gene-family-in-the-liver
#32
JOURNAL ARTICLE
Shuai Ma, Yan Wang, Liang Chen, Wenzheng Wang, Xinjuan Zhuang, Yuelong Liu, Ruqian Zhao
Betaine is widely used as a feed additive in the chicken industry to promote laying performance and growth performance, yet it is unknown whether betaine can be used in geese to improve the laying performance of goose breeders and the growth traits of offspring goslings. In this study, laying goose breeders at 39 weeks of age were fed basal (Control, CON) or betaine-supplemented diets at low (2.5 g/kg, LBT) or high (5 g/kg, HBT) levels for 7 weeks, and the breeder eggs laid in the last week were collected for incubation...
March 14, 2024: Journal of Animal Science
https://read.qxmd.com/read/38482596/the-relationship-between-thiamin-folic-acid-and-cognitive-function-in-a-rat-model-of-uremia
#33
JOURNAL ARTICLE
Yifei Lu, Chenqi Xu, Kewei Xie, Bingru Zhao, Minzhou Wang, Cheng Qian, Xuemei Chen, Leyi Gu, Wangshu Wu, Renhua Lu
End-stage renal disease is a worldwide health burden, but the pathogenesis of uremia-associated cognitive impairment (CI) is poorly recognized. We hypothesized that uremia brings about deficiency of thiamin and folic acid and causes CI by inducing oxidative stress. Therefore, 24 Sprague-Dawley rats were randomly divided into two groups: a 5/6 nephrectomy group ( n  = 12) and a sham-operated group ( n  = 12). The Morris water maze was used to assess the cognitive function eight weeks post-surgery, and serum levels of thiamin, folic acid and homocysteine were detected subsequently...
December 2024: Renal Failure
https://read.qxmd.com/read/38482446/function-of-homocysteine-and-he4-in-endometrial-carcinoma-verified-by-prospective-experiment
#34
JOURNAL ARTICLE
Zhaoxia Yang, Jianyun Zhou, Jiacong Wu, Guangquan Liu, Qinghua Xi
BACKGROUND: Timely diagnosis is the key factor to improve the prognosis of endometrial carcinoma (EC). To date, no particularly good markers could significantly improve the detection rate of EC. This study aimed to assess the utility of serum markers homocysteine (Hcy), human epididymal protein 4 (HE4), cancer antigen 199 (CA199), cancer antigen 125 (CA125), fibrinogen (Fib), and D-dimer (D-D) for EC diagnosis, especially Hcy of which its role in EC has not been noticed. METHODS: Pre-test and verification tests were performed...
February 29, 2024: Translational Cancer Research
https://read.qxmd.com/read/38481943/effect-of-high-frequency-5hz-rtms-stimulating-left-dlpfc-combined-with-galantamine-on-cognitive-impairment-after-ischemic-stroke-and-serum-homocysteine-and-neuron-specific-enolase
#35
JOURNAL ARTICLE
Guojin Hu, Li Zhang, Xiuli Sun, Lin Wang, Qian Xu, Qin Li, Wei Huang, Yao Xiao
OBJECTIVE: To investigate the efficacy of high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) combined with galantamine in patients with cognitive impairment after stroke and its effect on serum homocysteine (Hcy) and neuron-specific enolase (NSE) levels. METHODS: A total of 90 patients with cognitive impairment after the first ischemic stroke were enrolled. They were randomly divided into rTMS+ cognitive rehabilitation group, Galantamine + cognitive rehabilitation group, and rTMS+ Galantamine + cognitive rehabilitation group...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38479591/perspectives-on-folate-with-special-reference-to-epigenetics-and-neural-tube-defects
#36
REVIEW
Krishna Rao Gurugubelli, Vishnu Bhat Ballambattu
Folate is a micronutrient essential for DNA synthesis, cell division, fetal growth and development. Folate deficiency leads to genomic instability. Inadequate intake of folate during conception may lead to neural tube defects (NTDs) in the offspring. Folate influences the DNA methylation, histone methylation and homocysteine mediated gene methylation. DNA methylation influences the expression of microRNAs (miRNAs). Folate deficiency may be associated with miRNAs mis-regulation leading to NTDs. Mitochondrial epigenetics and folate metabolism has proved to be involved in embryogenesis and neural tube development...
March 11, 2024: Reproductive Toxicology
https://read.qxmd.com/read/38478042/optimal-folic-acid-dosage-in-lowering-homocysteine-precision-folic-acid-trial-to-lower-homocysteine-pfat-hcy
#37
JOURNAL ARTICLE
Xiao Huang, Huihui Bao, Congcong Ding, Junpei Li, Tianyu Cao, Lishun Liu, Yaping Wei, Ziyi Zhou, Nan Zhang, Yun Song, Ping Chen, Chongfei Jiang, Liling Xie, Xianhui Qin, Yan Zhang, Jianping Li, Ningling Sun, Genfu Tang, Xiaobin Wang, Hong Wang, Yong Huo, Xiaoshu Cheng
BACKGROUND: While folic acid (FA) is widely used to treat elevated total homocysteine (tHcy), promoting vascular health by reducing vascular oxidative stress and modulating endothelial nitric oxide synthase, the optimal daily dose and individual variation by MTHFR C677T genotypes have not been well studied. Therefore, this study aimed to explore the efficacy of eight different FA dosages on tHcy lowering in the overall sample and by MTHFR C677T genotypes. METHODS: This multicentered, randomized, double-blind, controlled clinical trial included 2697 eligible hypertensive adults with elevated tHcy (≥ 10 mmol/L) and without history of stroke and cardiovascular disease...
March 13, 2024: European Journal of Nutrition
https://read.qxmd.com/read/38477872/efficient-transferase-engineering-for-sam-analog-synthesis-from-iodoalkanes
#38
JOURNAL ARTICLE
Kai H Schülke, Jana S Fröse, Alina Klein, Marc Garcia-Borràs, Stephan C Hammer
S-Adenosyl-l-methionine (SAM) is an important cosubstrate in various biochemical processes, including selective methyl transfer reactions. Simple methods for the (re)generation of SAM analogs could expand the chemistry accessible with SAM-dependent transferases and go beyond methylation chemistry. Here we present an efficient enzyme engineering strategy to synthesize different SAM analogs from "off-the-shelf" iodoalkanes through enzymatic alkylation of S-adenosyl-l-homocysteine (SAH). This was achieved by mutating multiple hydrophobic and structurally dynamic amino acids simultaneously...
March 13, 2024: Chembiochem: a European Journal of Chemical Biology
https://read.qxmd.com/read/38475688/serum-interleukin-17%C3%A2-a-and-homocysteine-levels-in-children-with-autism
#39
JOURNAL ARTICLE
Hui Li, Yunhao Dang, Ying Yan
BACKGROUND: Autism Spectrum Disorder (ASD) is a neurodevelopmental condition that typically emerges early in childhood. This study aimed to explore the potential link between serum levels of vitamin B12 and homocysteine (Hcy) and the severity of ASD symptoms in children. METHODS: In this study, 50 children diagnosed with ASD comprised the observation group, while 50 healthy children constituted the control group. Serum levels of IL-17 A, Hcy, folate, and vitamin B12 were compared between the study group and control group, as well as among children with different degrees of ASD severity...
March 12, 2024: BMC Neuroscience
https://read.qxmd.com/read/38474861/diet-pattern-analysis-in-alzheimer-s-disease-implicates-gender-differences-in-folate-b12-homocysteine-axis-on-cognitive-outcomes
#40
JOURNAL ARTICLE
Chi-Ping Ting, Mi-Chia Ma, Hsin-I Chang, Chi-Wei Huang, Man-Chun Chou, Chiung-Chih Chang
BACKGROUND & AIMS: Low plasma B12 and folate levels or hyperhomocysteinemia are related to cognitive impairment. This study explores the relationships among diet pattern, blood folate-B12-homocysteine levels, and cognition measurement in Alzheimer's disease (AD) while exploring whether a gender effect may exist. METHODS: This cross-sectional study enrolled 592 AD patients (246 males, 346 females) and the demographic data, blood biochemical profiles, Mini-Mental State Examination (MMSE), and a Food Frequency Questionnaire (FFQ) for quantitative assessment of dietary frequency were collected...
March 4, 2024: Nutrients
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