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https://www.readbyqxmd.com/read/28715867/therapeutic-impact-of-grape-leaves-polyphenols-on-certain-biochemical-and-neurological-markers-in-alcl3-induced-alzheimer-s-disease
#1
Ibrahim H Borai, Magda K Ezz, Maha Z Rizk, Hanan F Aly, Mahmoud El-Sherbiny, Azza A Matloub, Ghadha I Fouad
Alzheimer's disease (AD) is a grave and prevailing neurodegenerative disease, characterized by slow and progressive neurodegeneration in different brain regions. Aluminum (Al) is a potent and widely distributed neurotoxic metal, implicated in the neuropathogenesis of AD. This study aimed to evaluate the possible neurorestorative potential of Vitis vinifera Leaves Polyphenolic (VLP) extract in alleviating aluminum chloride (AlCl3)-induced neurotoxicity in male rats. AlCl3 neurotoxicity induced a significant decrease in brain/serum acetylcholine (ACh) contents and serum dopamine (DA) levels, along with a significant increment of brain/serum acetylcholinesterase (AChE) activities...
July 13, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28715642/reduced-brain-volume-and-impaired-memory-in-betaine-homocysteine-s-methyltransferase-knockout-mice
#2
Emily A K Prieur, Eneda Pjetri, Steven H Zeisel, Nafisa M Jadavji
Using a mouse model, this study examined the impact of lack of betaine homocysteine S-methyltransferase (BHMT) on neurological function. Bhmt-/- mice maintained on a control diet had elevated concentrations of homocysteine, reduced total brain MRI volume, as well as impaired reference and short- term memories. The results of this study indicate that the absence of BHMT may play a role in neurological function.
July 17, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28713986/hydrogen-sulfide-prevents-homocysteine%C3%A2-induced-endoplasmic-reticulum-stress-in-pc12-cells-by-upregulating-sirt%C3%A2-1
#3
Chun-Yan Wang, Wei Zou, Xiao-Yu Liang, Zhi-Sheng Jiang, Xiang Li, Hai-Jun Wei, Yi-Yun Tang, Ping Zhang, Xiao-Qing Tang
It was previously confirmed that hydrogen sulfide (H2S) has a neuroprotective effect, preventing homocysteine‑induced neurotoxicity. However, the exact molecular mechanisms underlying this protective effect remain to be fully elucidated. Endoplasmic reticulum (ER) stress contributes to homocysteine‑induced neurotoxicity. Silent mating type information regulator 2 homolog 1 (SIRT‑1) can attenuate ER stress, exerting its neuroprotective effect. Therefore, the present study aimed to investigate whether H2S protects PC12 cells against homocysteine‑induced ER stress and whether SIRT‑1 mediates this protective effect of H2S...
July 15, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28712423/anxiety-and-depression-in-patients-three-months-after-myocardial-infarction-association-with-markers-of-coagulation-and-the-relevance-of-age
#4
Franziska Geiser, Anne Sarah Urbach, Ursula Harbrecht, Rupert Conrad, Bernd Pötzsch, Nele Amann, Katharina Kiesewetter, Alexandra Sieke, Kyra Wolffs, Dirk Skowasch
OBJECTIVE: Anxiety and depression are associated with an activation of coagulation and an impairment of fibrinolysis, which may contribute to the increased cardiovascular risk associated with the two disorders. However, very few studies have examined the impact of psychological distress on coagulation factors in coronary artery disease patients. The aim of this study was to assess the correlation between anxiety/depression and factors of coagulation and fibrinolysis in patients who had suffered an acute MI three months prior...
August 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28712006/an-inframe-trinucleotide-deletion-in-mtrr-exon-1-is-associated-with-the-risk-of-spina-bifida
#5
Jun Zhang, Xiao-Lu Dai, Gui-Cen Liu, Juan Wang, Xue-Yi Ren, Mu-Hua Jin, Nan-Nan Mi, Shu-Qin Wang
Maternal genetic variants of enzymes in folate-homocysteine metabolic network are significantly correlative with the risk of spina bifida. To survey the genetic causality, the genotypes of three women having spina bifida fetuses from two unrelated Chinese families were screened in candidate alleles. Polymerase chain reaction, capillary electrophoresis and Sanger sequencing were employed to recognize the allelic variation. A trinucleotide deletion (c.4_6delAGG) was identified in the first exon of MTRR. All the three women showed the novel clinical variation including one heterozygous and two homozygous...
July 15, 2017: Neuromolecular Medicine
https://www.readbyqxmd.com/read/28709892/liuwei-dihuang-soft-capsules-attenuates-endothelial-cell-apoptosis-to-prevent-atherosclerosis-through-gpr30-mediated-regulation-in-ovariectomized-apoe-deficient-mice
#6
Yi Jing, Danfeng Cai, Qi Chen, Qingping Xiong, Tianhui Hu, Yuan Yao, Chao Lin, Xin Sun, Ying Lu, Xueyun Kong, Xiang Wu, Yu Li, Huimin Bian
ETHNOPHARMACOLOGICAL RELEVANCE: Liuwei Dihuang (LWDH), a classical traditional Chinese medicine prescription, has been widely used to prevent and to treat various diseases with symptoms of 'Kidney-Yin' deficiency syndrome for over 1000 years in China. It is commonly used to treat functional decline associated with senile disease and menopausal syndrome, especially memory decline, insomnia, diabetes and osteoporosis. Modern experimental pharmacological studies indicated that the mechanism of LWDH treatment of menopausal syndrome may be associated with enhanced estrogenic effects...
July 12, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28709390/elevated-homocysteine-in-human-abdominal-aortic-aneurysmal-tissues
#7
Crystal Yin Tung Chan, Stephen Wing Keung Cheng
An abnormally high level of homocysteine (Hcy) has been consistently observed in the blood of abdominal aortic aneurysm (AAA) patients. However, the expression of Hcy in human AAA tissues has not been investigated. In this study, the expression of Hcy in aneurysmal tissues from AAA patients ( n=30) was compared with non-aneurysmal tissues from organ donors ( n=31) by dot blotting and immunohistochemistry. A significantly higher expression of Hcy was observed in AAA than control tissues ( p<0.001). Furthermore, the associations of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism, detected by polymerase chain reaction-restriction fragment length polymorphism, with both AAA and tissue Hcy expression were evaluated...
July 1, 2017: Vascular Medicine
https://www.readbyqxmd.com/read/28705714/aristeromycin-and-dznep-cause-growth-inhibition-of-prostate-cancer-via-induction-of-mir-26a
#8
Noriko Uchiyama, Yukiya Tanaka, Tomohiro Kawamoto
Most prostate cancers initially respond to androgen deprivation therapy, but then progress from androgen-dependent to androgen-independent prostate cancers. In the present study, a differential cytotoxicity screen of hormone-resistant prostate cancer LNCaP-hr cells and the parental LNCaP-FGC cells against normal MRC5 fibroblast cells, identified a small molecule compound, Aristeromycin (a derivative of 3-deazaneplanocin A (DZNeP)). The molecular target was shown to be S-adenosylhomocysteine hydrolase (AHCY), which catalyzes reversible hydrolysis of S-adenosylhomocysteine (SAH) to adenosine and L-homocysteine...
July 10, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28705458/insulin-resistance-and-elevated-c-reactive-protein-among-first-degree-relatives-of-ischemic-stroke-patients
#9
Krishnamoorthy Srilatha, Zachariah Bobby, D K Subrahmanyam, Uppoor NithinKumar
BACKGROUND: Family history is one of the non-modifiable risk factors for ischemic stroke. Atherosclerosis and thrombosis are the two major mechanisms for cardiovascular disease and stroke. Screening of family members is an important method to identify individuals at risk. Therefore, this study was planned to assess the atherosclerotic risk factors in first-degree relatives of patients with ischemic stroke. METHODOLOGY: Case group included 40 first-degree relatives of ischemic stroke patients between 30 and 50 years of age...
July 4, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28705092/serum-allantoin-and-aminothiols-as-biomarkers-of-chronic-heart-failure
#10
Elizabeth Caussé, Pauline Fournier, Jérome Roncalli, Robert Salvayre, Michel Galinier
Background Oxidative stress (OS) represents the primary mediator of chronic heart failure (CHF) development and progression. It is well established that homocysteine is able to generate reactive oxygen species. Small amounts of allantoin in human serum result from free radical action on urate and may provide a stable marker for in vivo free radical activity. To investigate whether some easily measurable indexes such as antioxidants (uric acid, glutathione) and related molecules (allantoin, homocysteine and cysteine) can serve as OS biomarkers...
July 14, 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/28701466/methionine-synthase-is-localized-to-the-nucleus-in-pichia-pastoris-and-candida-albicans-and-to-the-cytoplasm-in-saccharomyces-cerevisiae
#11
Umakant Sahu, Hunsur R Vinod Kumar, Shankar S Kapnoor, Raghu Bhagavat, Nagasuma Chandra, Pundi N Rangarajan
Methionine synthase (MS) catalyzes methylation of homocysteine, the last step in the biosynthesis of methionine, which is essential for the regeneration of tetrahydrofolate and biosynthesis of S-adenosyl methionine. Here, we report that MS is localized to the nucleus of Pichia pastoris and Candida albicans but cytoplasmic in Saccharomyces cerevisiaeP. pastoris strain carrying a deletion of MET6 gene encoding MS (Ppmet6) exhibits methionine as well as adenine auxotrophy indicating that MS is required for methionine as well as adenine biosynthesis...
July 12, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28698752/correlation-between-serum-homocysteine-and-vitiligo-area-scoring-index
#12
Dina R U Hasibuan, Imam B Putra, Nelva K Jusuf
BACKGROUND: Vitiligo is a chronic skin disorder. White macules caused by melanocyte destruction is a characteristic finding that cosmetically disturbing. Until recently, pathogenesis of vitiligo is still unclear. The role of homocysteine in vitiligo is mentioned in previous studies thus it is probable that it can be a biomarker to determine vitiligo severity. AIM: To determine correlation between serum homocysteine and vitiligo area Scoring Index (VASI). SUBJECT AND METHOD: This was a cross-sectional analytic study which involved 30 vitiligo patients that were diagnosed by clinical and Wood's lamp examinations then VASI score was determined and same numbers of control...
June 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28698453/plasma-homocysteine-and-serum-folate-and-vitamin-b12-levels-in-mild-cognitive-impairment-and-alzheimer-s-disease-a-case-control-study
#13
Fei Ma, Tianfeng Wu, Jiangang Zhao, Lu Ji, Aili Song, Meilin Zhang, Guowei Huang
Homocysteine (Hcy) is a risk factor for brain atrophy, cognitive impairment, and dementia. Vitamin B12 and folate are cofactors necessary for the methylation of Hcy. However, there is some debate regarding the differing levels of plasma Hcy and serum folate and vitamin B12 among healthy controls, patients with mild cognitive impairment (MCI), and patients with Alzheimer's disease (AD). This study aimed to evaluate how the levels of plasma Hcy and its biological determinants, folate and vitamin B12, are related to MCI and AD in older Chinese adults...
July 8, 2017: Nutrients
https://www.readbyqxmd.com/read/28697391/nutrients-in-one-carbon-metabolism-and-urinary-arsenic-methylation-in-the-national-health-and-nutrition-examination-survey-nhanes-2003-2004
#14
Margaret Kurzius-Spencer, Vanessa da Silva, Cynthia A Thomson, Vern Hartz, Chiu-Hsieh Hsu, Jefferey L Burgess, Mary Kay O'Rourke, Robin B Harris
Exposure to inorganic arsenic (inAs), a potent toxicant, occurs primarily through ingestion of food and water. The efficiency with which it is methylated to mono and dimethyl arsenicals (MMA and DMA) affects toxicity. Folate, vitamins B12 and B6 are required for 1C metabolism, and studies have found that higher levels of these nutrients increase methylation capacity and are associated with protection against adverse health effects from inAs, especially in undernourished populations. Our aim was to determine whether 1C-related nutrients are associated with greater inAs methylation capacity in a general population sample with overall adequate nutrition and low levels of As exposure...
July 8, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28693733/a-fluorescent-dyad-with-large-emission-shift-for-discrimination-of-cysteine-homocysteine-from-glutathione-and-hydrogen-sulfide-and-the-application-of-bioimaging
#15
Xueling Yang, Longwei He, Kaixin Xu, Weiying Lin
Biothiols, as reactive sulfur species (RSS), play important roles in human physiology, and they have a close connection of generation and metabolism pathways among of them. It is challenging to discriminate biothiols from each other due to the similar chemical structures and properties of them. Herein, we develop a fluorescent hybrid dyad (CS-NBD) for efficiently discriminating cysteine (Cys)/homocysteine (Hcy) from glutathione (GSH) and hydrogen sulfide (H2S) by a dual-channel detection method. CS-NBD performs inherently no fluorescence in ranging from visible to near infrared region...
August 15, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28693429/plasma-homocysteine-levels-associated-with-a-corrected-qt-interval
#16
Zhao Li, Xiaofan Guo, Guozhe Sun, Liqiang Zheng, Yingxian Sun, Yamin Liu, Maria Roselle Abraham
BACKGROUND: Little is known about the relationship between homocysteine (Hcy) levels and the QT interval. We examined the association of different Hcy levels with corrected QT (QTc) intervals in a general population. METHODS: Plasma levels of Hcy were assessed in a population-based study of 7002 participants 35 years of age and older from 2012 to 2013. Twelve-lead ECGs were performed on all participants and analyzed automatically. RESULTS: The distribution of Hcy levels was determined for an entire population after the data were grouped into quartiles (Q1: <=11...
July 11, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28692411/evaluation-of-the-health-benefits-of-a-multivitamin-multimineral-herbal-essential-oil-infused-supplement-a-pilot-trial
#17
Xuesheng Han, Dennis L Eggett, Tory L Parker
This study was designed to quantitatively evaluate the health benefits of a multivitamin, multimineral, herbal, essential oil-infused supplement using serum biomarkers. We also qualitatively evaluated the health effects of this supplement using a survey. Sixteen participants were recruited to take the supplement as directed for two months. The levels of the following serum components were measured in the participants: total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, triglycerides, lipoprotein(a), LDL/HDL cholesterol ratio, total/HDL cholesterol ratio, ferritin, fibrinogen, C-reactive protein, insulin, testosterone, sex hormone binding globulin, free androgen index, red blood cell magnesium, homocysteine, coenzyme Q10, lipid peroxides, alpha-tocopherol, gamma-tocopherol, cardiovascular index, eicosapentaenoic acid (EPA), arachidonic acid (AA), and the AA/EPA ratio...
July 10, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28691407/oxidative-stress-hepcidin-and-nesfatin-i-status-in-childhood-iron-and-vitamin-b12-deficiency-anemias
#18
Tünay Kontaş Aşkar, Olga Büyükleblebici, Adnan Adil Hismioğulları, Zeynep Hünkerler
BACKGROUND: Anemia is a disease that is long and often repetitive and can result in great burden to the national economy. The most frequent nutritional deficiency anemias in children are related with iron and vitamin B12 deficiencies. OBJECTIVES: The aim of this study was to determine the oxidative stress, hepcidin, and nesfatin-I levels in childhood iron and vitamin B12 deficiency anemias. MATERIAL AND METHODS: The study had three groups of 15 children, iron anemia deficiency group, vitamin B12 deficiency group and a control group...
June 27, 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28689805/the-importance-of-folate-vitamins-b6-and-b12-for-the-lowering-of-homocysteine-concentrations-for-patients-with-recurrent-pregnancy-loss-and-mthfr-mutations
#19
Danielius Serapinas, Evelina Boreikaite, Agne Bartkeviciute, Rita Bandzeviciene, Mindaugas Silkunas, Daiva Bartkeviciene
In patients with MTHFR (methylenetetrahydrofolate reductase) mutations and hyperhomocysteinemia, recurrent pregnancy loss is a frequent feature. The aim of the study was to evaluate the impact of folic acid, vitamins B6 and B12 supplementation for the lowering of total homocysteine concentrations and pregnancy. 16 patients who had had 3 or more miscarriages and MTHFR mutations were used in the study. They received methylfolate (5mg/day), vitamin B6 (50mg/day) and vitamin B12 (1mg/week). Supplementation induced a decrease in homocysteine from 19...
July 6, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28689750/characteristics-and-long-term-prognosis-of-patients-%C3%A2-35-years-of-age-with-st-segment-elevation-myocardial-infarction-and-normal-or-near-normal-coronary-arteries
#20
Loukianos S Rallidis, Argyri Gialeraki, Andreas S Triantafyllis, Georgios Tsirebolos, Georgios Liakos, Paraskevi Moutsatsou, Efstathios Iliodromitis
There are scarce data regarding risk factors and prognosis of patients with premature ST segment elevation myocardial infarction (STEMI) and "normal or near normal" coronary arteries (N/NNCAs). We compared the characteristics and long-term prognosis of patients with premature STEMI and N/NNCAs with their counterparts with significant coronary artery disease (CAD). We recruited 330 patients who had STEMI ≤35 years of age and 167 age- and gender-matched controls. All patients underwent coronary angiography...
June 13, 2017: American Journal of Cardiology
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