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https://www.readbyqxmd.com/read/29222982/association-between-mthfr-variant-and-diabetic-neuropathy
#1
Armita Kakavand Hamidi, Mania Radfar, Mahsa M Amoli
BACKGROUND: Methylene-tetrahydrofolate reductase (MTHFR) gene variant may play an important role in the pathophysiology of diabetes and its complications due to its influence on plasma homocysteine levels and also its effect on scavenging peroxynitrite radicals. Diabetic peripheral neuropathy (DPN) is one of the most common diabetic chronic complications. The aim of this study was to investigate the relationship between diabetic neuropathy and MTHFR gene C677T and 1298A ⁄C polymorphisms...
April 26, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29222856/homocysteine-as-a-non-classical-risk-factor-for-atherosclerosis-in-relation-to-pharmacotherapy-of-type-2-diabetes-mellitus
#2
Magdalena Borowska, Marzena Dworacka, Hanna Winiarska, Ewa Krzyżagórska
AIMS: The aim of our study was to evaluate which of the pharmacotherapeutic methods that are frequently used to treat type 2 diabetes is associated with the most beneficial profile in relation to pro-atherogenic homocysteine levels. PATIENTS AND METHODS: We measured the serum homocysteine level in 182 patients with type 2 diabetes treated with metformin (89), treated with insulin in combination with metformin (31), receiving sulfonylureas (31) and treated conventionally with insulin (31)...
December 7, 2017: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/29218905/considerations-for-automated-machine-learning-in-clinical-metabolic-profiling-altered-homocysteine-plasma-concentration-associated-with-metformin-exposure
#3
Alena Orlenko, Jason H Moore, Patryk Orzechowski, Randal S Olson, Junmei Cairns, Pedro J Caraballo, Richard M Weinshilboum, Liewei Wang, Matthew K Breitenstein
With the maturation of metabolomics science and proliferation of biobanks, clinical metabolic profiling is an increasingly opportunistic frontier for advancing translational clinical research. Automated Machine Learning (AutoML) approaches provide exciting opportunity to guide feature selection in agnostic metabolic profiling endeavors, where potentially thousands of independent data points must be evaluated. In previous research, AutoML using high-dimensional data of varying types has been demonstrably robust, outperforming traditional approaches...
2018: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/29215704/cardiovascular-biochemical-risk-factors-among-women-with-spontaneous-preterm-delivery
#4
Karst Y Heida, Marlies A Kampman, Arie Franx, Monique W De Laat, Barbara J Mulder, Joris A Van der Post, Catia M Bilardo, Petronella G Pieper, Krystyna M Sollie, Gertjan T Sieswerda, Carrie Ris-Stalpers, Martijn A Oudijk
OBJECTIVE: To determine whether women delivering preterm have unfavorable cardiovascular profiles as compared with women who deliver at term. METHODS: A prospective observational cohort study enrolled 165 women with spontaneous preterm delivery (sPTD) at 24+0 and 36+6 gestational weeks in three perinatal care centers in The Netherlands between August 2012 and August 2014. Total cholesterol, triglycerides, high-density lipoprotein (HDL)-cholesterol, low-density lipoprotein (LDL)-cholesterol, apolipoprotein, glucose, and homocysteine were measured within 24 hours after delivery...
December 7, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29212772/modifiable-pathways-in-alzheimer-s-disease-mendelian-randomisation-analysis
#5
Susanna C Larsson, Matthew Traylor, Rainer Malik, Martin Dichgans, Stephen Burgess, Hugh S Markus
OBJECTIVE: To determine which potentially modifiable risk factors, including socioeconomic, lifestyle/dietary, cardiometabolic, and inflammatory factors, are associated with Alzheimer's disease. DESIGN: Mendelian randomisation study using genetic variants associated with the modifiable risk factors as instrumental variables. SETTING: International Genomics of Alzheimer's Project. PARTICIPANTS: 17 008 cases of Alzheimer's disease and 37 154 controls...
December 6, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29212064/mthfr-a1298c-and-c677t-polymorphisms-are-associated-with-increased-risk-of-venous-thromboembolism-a-retrospective-chart-review-study
#6
Fang Liu, Danuzia Silva, Mariuxi Viteri Malone, Kala Seetharaman
BACKGROUND: Methylene tetrahydrofolate reductase (MTHFR) is a key enzyme in homocysteine metabolism. This study aims to determine the impact of MTHFR polymorphisms on plasma homocysteine levels and risks of venous thromboembolism (VTE). METHODS: This retrospective chart review study included a total of 188 subjects who were tested for MTHFR polymorphisms at Metrowest Coagulation Laboratory between April 2011 and April 2016. Two independent coders were trained to extract relevant clinical data for statistical analysis...
December 7, 2017: Acta Haematologica
https://www.readbyqxmd.com/read/29210571/molecular-engineering-of-%C3%AE-substituted-acrylate-ester-template-for-efficient-fluorescence-probe-of-hydrogen-polysulfides
#7
JingRu Guo, Sheng Yang, Chongchong Guo, Qinghai Zeng, Zhihe Qing, Zhong Cao, Jishan Li, Ronghua Yang
In this article, hydrogen polysulfide (H2Sn)-mediated Michael addition/cyclization cascade reactions toward acrylate ester analogues had been exploited and utilized to construct novel and robust H2Sn-specific fluorescence probe for the first time. Through rational molecular engineering of the α-substituted acrylate ester template, the optimal candidate probe FP-CF3 containing trifluoromethyl-substituted acrylate ester group as recognition unit and 3-benzothiazol-7-hydroxycoumarin dye BHC as signal reporter can highly selectively detect H2Sn over other reactive sulfur species, especially biothiols including cysteine (Cys), homocysteine (Hcy)/glutathione (GSH), with a rapid and significant turn-on fluorescence response (less than 60 secondsfor response time and over 44-fold for signal-to-background ratio)...
December 6, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29209773/effect-of-8-week-oral-supplementation-with-3-%C3%A2%C2%B5g-cyano-b12-or-hydroxo-b12-in-a-vitamin-b12-deficient-population
#8
Eva Greibe, Namita Mahalle, Vijayshri Bhide, Sergey Fedosov, Christian W Heegaard, Sadanand Naik, Ebba Nexo
PURPOSE: We compare the effect of 8-week oral supplementation with cyano-B12 (currently used in vitamin pills) and hydroxo-B12 (predominant form in the diet) in a population with nutritional vitamin B12 deficiency. METHODS: Fifty-one healthy Indian adults with baseline serum cobalamin < 200 pmol/L were supplied for 8 weeks with daily oral supplements of 3-µg cyano-B12 (n = 15), 3-µg hydroxo-B12 (n = 16), or a placebo (n = 20). Blood at baseline, and each following week, was examined for total cobalamin, holotranscobalamin, methylmalonic acid, and homocysteine...
December 5, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/29209581/methylenetetrahydrofolate-reductase-a1298c-polymorphism-and-major-depressive-disorder
#9
REVIEW
Kevin Cho, Zubair M Amin, Jie An, Kerry Anne Rambaran, Tyler B Johnson, Saeed K Alzghari
Major depressive disorder (MDD) is a disorder that carries significant psychosocial and economic implications. Research efforts have focused on identifying biomarkers that can aid in the prediction, diagnosis, and efficacious treatment of MDD. Most of this focus has been placed on a polymorphism of the methylenetetrahydrofolate reductase (MTHFR) gene, C677T. MTHFR C677T is screened during MDD diagnosis in many protocols. However, MTHFR C667T poses conflicting data in various ethnic groups and geographic populations calling into question its utility...
October 1, 2017: Curēus
https://www.readbyqxmd.com/read/29208885/serum-homocysteine-and-its-association-with-glycemic-control-in-type-2-diabetic-patients
#10
M Majumder, F H Mollah, M Hoque, S A Ferdous
In developing countries like Bangladesh the prevalence of type 2 diabetes mellitus is increasing day by day. Among the long-term complications of diabetes mellitus, vascular complications represent a major cause of morbidity and mortality. Hyperglycemia is still considered the principal cause of diabetes complications. Total plasma homocysteine (tHcy) is an emerging cardiovascular risk factor. Hyperhomocysteinemia independently appears to be a stronger risk factor for mortality than other risk factors in type 2 diabetes than in non diabetes...
October 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29208848/assessment-of-homocysteine-as-a-diagnostic-and-early-prognostic-biomarker-for-patients-with-acute-lacunar-infarction
#11
Huimin Fan, Shuna Yang, Yue Li, Jiangmei Yin, Wei Qin, Lei Yang, Junliang Yuan, Wenli Hu
BACKGROUND: Although increasing evidence has demonstrated that elevated homocysteine (Hcy) levels may be an important contributor for the development of cerebral infarction, rare studies focused on its diagnostic and early prognostic roles in acute lacunar infarction. METHODS: A total of 197 patients with acute lacunar infarction and 192 to form the control group were prospectively recruited between January 2013 and February 2017. Early neurological deterioration was defined as an increase of ≥2 points in National Institutes of Health Stroke Scale or the decrease in Barthel index (BI) score at discharge...
November 29, 2017: European Neurology
https://www.readbyqxmd.com/read/29207695/association-of-glycated-haemoglobin-and-serum-apolipoproteins-with-diabetic-retinopathy-an-indian-overview
#12
Bhasker Mukherjee, Sandeep Shankar, Rehan Ahmed, Kanchan Singh, Kapil Bhatia
Introduction: India is presently facing an epidemic of diabetes mellitus and the risks of chronic complications from the disease are associated with the duration of the disease as well as the degree of hyperglycaemia. Diabetic retinopathy is a known microvascular complication of diabetes mellitus and is the most common cause of blindness in the western countries.Apolipoproteins are the protein component of lipoproteins. Apart from acting as structural proteins, they also act as cofactors to various enzymes...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29206808/extrinsic-calcitonin-gene-related-peptide-inhibits-hyperoxia-induced-alveolar-epithelial-type-ii-cells-apoptosis-oxidative-stress-and-reactive-oxygen-species-ros-production-by-enhancing-notch-1-and-homocysteine-induced-endoplasmic-reticulum-protein-herp-expression
#13
Yu-Xin Bai, Fang Fang, Jia-Ling Jiang, Feng Xu
BACKGROUND Lung alveolar epithelial type II cells (AEC II) are the most important stem cells in lung tissues, which are critical for wound repair of bronchopulmonary dysplasia (BPD). This study investigated the effects of calcitonin gene-related peptide (CGRP) on AEC II cells exposed to hyperoxia. MATERIAL AND METHODS Neonatal rat AEC II cells were isolated and identified by detecting surfactant protein C (SP-C). Three small interfering RNAs targeting Notch 1 were synthesized and transfected into AEC II. A hyperoxia-exposed AEC II cell injury model was established and was divided into 8 groups...
December 5, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29204947/improved-sp1-and-betaine-homocysteine-s-methyltransferase-expression-and-homocysteine-clearance-are-involved-in-the-effects-of-zinc-on-oxidative-stress-in-high-fat-diet-pretreated-mice
#14
Li Wu, Xihong Zhou, Tiejun Li, Juyun He, Linli Huang, Zicheng Ouyang, Liuqin He, Tao Wei, Qinghua He
Zinc plays a role in alleviating oxidative stress. However, the related mechanisms remain to be further elucidated. The present study was conducted to investigate whether the recovery of oxidative stress in high-fat-diet (HFD)-pretreated mice was affected by zinc. Male mice received either an HFD or a low-fat-diet (LFD) for 8 weeks. Then, the mice fed with HFD and LFD were both assigned to either a control diet (30 mg zinc, ZD) or a no-added zinc diet (NZD) for an additional 4 weeks. The results showed that after feeding with NZD for 4 weeks, the HFD-pretreated mice had the highest plasma glucose and insulin concentrations, while had the lowest CuZn-SOD and glutathione concentrations...
December 4, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/29203427/the-association-between-plasma-homocysteine-and-ambulatory-blood-pressure-variability-in-patients-with-untreated-hypertension
#15
Suhua Li, Jieming Zhu, Lin Wu, Long Peng, Yanting Luo, Yunyue Zhao, Ruimin Dong, Lin Chen, Xixiang Tang, Jinlai Liu
BACKGROUND: Both homocysteine (Hcy) and blood pressure variability (BPV) are independent predictors of stroke, however, their relationship is rarely evaluated before. This study aimed to investigate the association Hcy and ambulatory BPV in subjects with untreated primary hypertension. METHODS: A total of 252 eligible patients were recruited. Plasma Hcy was measured and 24-h ambulatory blood pressure monitoring was performed for each subject. The systolic and diastolic BPV values were calculated as the SD of individual blood pressure values during 24h, daytime and nighttime, and then stratified by the tertiles of Hcy concentration (T1 to T3)...
December 2, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29202788/mthfr-a1298c-polymorphisms-reduce-the-risk-of-congenital-heart-defects-a-meta-analysis-from-16-case-control-studies
#16
REVIEW
Di Yu, Zhulun Zhuang, Zhongyuan Wen, Xiaodong Zang, Xuming Mo
BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) plays a crucial role in the hyperhomocysteinemia, which is a risk factor related to the occurrence of congenital heart defect (CHD). However, the association between MTHFR polymorphism and CHD has been inconclusive. METHODS: We conducted an updated meta-analysis to provide comprehensive evidence on the role of MTHFR A1298C polymorphism in CHD. Databases were searched and a total of 16 studies containing 2207 cases and 2364 controls were included...
December 4, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/29201182/the-efficacy-of-gastrodin-in-combination-with-folate-and-vitamin-b12-on-patients-with-epilepsy-after-stroke-and-its-effect-on-hmgb-1-il-2-and-il-6-serum-levels
#17
Hao Zhou, Nuan Wang, Lei Xu, Hongli Huang, Chunyu Yu
This study evaluated the efficacy of gastrodin in combination with folate (FOL) and vitamin-B12 (V-B12) on patients with epilepsy after stroke (EAS) and its effect on high-mobility group protein B1 (HMGB-1), interleukin-1 (IL-1), and IL-6 serum levels. The clinical data of 92 EAS patients admitted for treatment between April, 2014 and March, 2016 were collected. These patients were randomly divided into control and observation groups (n=46 each) using computer software. Patients in the control group were administered only regular antiepileptic drugs, whereas observation group patients also received a combination of gastrodin, FOL and V-B12...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29198136/hyperhomocysteinemia-induced-gene-expression-changes-in-the-cell-types-of-the-brain
#18
Erica M Weekman, Abigail E Woolums, Tiffany L Sudduth, Donna M Wilcock
High plasma levels of homocysteine, termed hyperhomocysteinemia, are a risk factor for vascular cognitive impairment and dementia, which is the second leading cause of dementia. While hyperhomocysteinemia induces microhemorrhages and cognitive decline in mice, the specific effect of hyperhomocysteinemia on each cell type remains unknown. We took separate cultures of astrocytes, microglia, endothelial cells, and neuronal cells and treated each with moderate levels of homocysteine for 24, 48, 72, and 96 hr...
November 2017: ASN Neuro
https://www.readbyqxmd.com/read/29197198/cardiovascular-disease-risk-factors-in-patients-with-posttraumatic-stress-disorder-ptsd-a-narrative-review
#19
Marina Šagud, Nenad Jakšić, Bjanka Vuksan-Ćusa, Mladen Lončar, Ivana Lončar, Alma Mihaljević Peleš, Davor Miličić, Miro Jakovljević
Posttraumatic stress disorder (PTSD) is a chronic condition related to severe stress and trauma. There is a mounting evidence about increased prevalence and mortality from cardiovascular diseases (CVD) in patients with PTSD. This review summarizes the current data on possible relations between PTSD and increased risks of CVD, including biological, psychological and behavioral factors. Biological factors refer to increased prevalence of metabolic syndrome (MetS), hypertension, elevation of pro-inflammatory cytokines and homocysteine levels...
December 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/29195982/high-resolution-mass-approach-to-characterize-refrigerated-black-truffles-stored-under-different-storage-atmospheres
#20
Edoardo Longo, Ksenia Morozova, Monica R Loizzo, Rosa Tundis, Sara Savini, Roberta Foligni, Massimo Mozzon, Daniel Martin-Vertedor, Matteo Scampicchio, Emanuele Boselli
Freshly harvested Tuber melanosporum samples were packed and stored at 4°C under reduced atmospheric pressure or modified atmosphere for four weeks. Multivariate analysis was employed to correlate the antioxidant power of the ethanolic extracts of the samples with the chemical composition determined by high resolution mass spectrometry. High performance liquid chromatography coupled with a coularray detector was applied to select the chemical species associated with the antioxidant power. Four classes of chemical compounds were investigated in more detail by a targeted approach: derivatives of glutathione, adenine (such as S-adenosyl-homocysteine), oxidized linoleic acid and ergosterol...
December 2017: Food Research International
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