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https://www.readbyqxmd.com/read/29050786/homocysteine-in-non-valvular-atrial-fibrillation-role-and-clinical-implications
#1
REVIEW
Yan Yao, Mei-Sheng Shang, Jian-Zeng Dong, Chang-Sheng Ma
Atrial fibrillation (AF), the most common sustained arrhythmia, is associated with a series of adverse complications that cause so-called AF socioeconomic burden. Apart from the classical risk factors, it seems to be novel factors that increase the risk of AF and AF-related stroke. Recently, more and more evidence has well documented the close relationships between homocysteine (Hcy) and AF. As a well-known marker for pro-oxidation and pro-inflammation, Hcy plays an important role in a number of vascular diseases having strong association with AF...
October 16, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29047374/ideal-cardiovascular-health-and-the-subclinical-impairments-of-cardiovascular-diseases-a-cross-sectional-study-in-central-south-china
#2
Ya-Qin Wang, Chang-Fa Wang, Ling Zhu, Hong Yuan, Liu-Xin Wu, Zhi-Heng Chen
BACKGROUND: Ideal cardiovascular health (CVH) is related to a low cardiovascular disease risk profile. This study aimed to investigate CVH metrics with both the biomarkers and markers of subclinical impairments of cardiovascular diseases (CVDs) in subjects from central south China. METHODS: The ideal CVH score (non-smoking status; ideal body mass index; regular physical activity; healthy diet; and an optimal serum cholesterol, blood pressure, and glucose profile; 1 point for each; total score: 0-7) was collected from 3009 participants without a history of CVDs...
October 18, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29045954/-pulmonary-arterial-hypertension-as-leading-manifestation-of-methylmalonic-aciduria-clinical-characteristics-and-gene-testing-in-15-cases
#3
X Q Liu, H Yan, J X Qiu, C Y Zhang, J G Qi, X Zhang, H J Xiao, Y L Yang, Y H Chen, J B DU
OBJECTIVE: To deepen our understanding of Methylmalonic aciduria (MMA) associated pulmonary hypertension (PH) by analyzing the characteristics of clinical presentation, pulmonary high resolusion CT(HRCT), treatment response and gene mutation. METHODS: This study includes 15 cases of pediatric patients with MMA associated PH diagnosed and treated in Peking University First Hospital pediatric department between May 2012 and May 2016 with symptoms of PH as their leading presentation...
October 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29043995/clinical-research-of-homocysteine-high-sensitive-c-reactive-protein-and-d-dimer-in-patients-with-vascular-dementia
#4
Li Zhang, Na Liu, Jinying Zhang, Hui Zhang, Ying Zhang
Aim of the present research work was to study the relationship between the degree of dementia and the serum levels of homocysteine(Hcy), high-sensitive C-reactive protein(hs-CRP), D-Dimer and vascular dementia(VaD) of patients, and to investigate the mechanism of Hcy, hs-CRP and D-Dimer in the vascular dementia. Subjects were divided into normal group and VaD group. CRP and D-Dimer protein of each sample were detected by nephelometry method, and the serum Hcy level was detected by Fluorescent labeling immunoassay method...
July 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29043878/the-association-between-homocysteine-and-systemic-sclerosis-a-review-of-the-literature-and-meta-analysis
#5
Yan-Jie Zhang, Li Zhang, Xiao-Lei Huang, Yu Duan, Li-Juan Yang, Jing Wang
OBJECTIVES: The main objective of this study was to summarize the existing evidence and quantitatively evaluate whether serum/plasma levels of homocysteine (Hcy) were associated with sclerosis (SSc) diseases by performing a meta-analysis of previous studies. METHODS: PubMed, Elsevier ScienceDirect and Cochrane Library databases were used to obtain all relative published literatures. Stata version 11.0 (StataCorp, College Station, TX) was used for statistical analysis...
October 18, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/29042490/remote-ischemic-conditioning-may-improve-outcomes-of-patients-with-cerebral-small-vessel-disease
#6
Yuan Wang, Ran Meng, Haiqing Song, Gang Liu, Yang Hua, Dehua Cui, Lemin Zheng, Wuwei Feng, David S Liebeskind, Marc Fisher, Xunming Ji
BACKGROUND AND PURPOSE: We aimed to evaluate the efficacy of remote ischemic conditioning (RIC) in patients with cerebral small-vessel disease. METHODS: Thirty patients with cerebral small-vessel disease-related mild cognitive impairment were enrolled in this prospective, randomized controlled study for 1 year. Besides routine medical treatment, participants were randomized into the experimental group (n=14) undergoing 5 cycles consisting of ischemia followed by reperfusion for 5 minutes on both upper limbs twice daily for 1 year or the control group (n=16) who were treated with sham ischemia-reperfusion cycles...
October 17, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29041003/depression-in-the-context-of-medical-disorders-new-pharmacological-pathways-revisited
#7
Undine E Lang, Marc Walter
The depressive state has been characterised as one of elevated inflammation, changed cardiovascular parameters and a deranged metabolic situation all of which holds promise for a better understanding and handling of treatment-resistance in affective disorders as well as for future developments in treatment algorithms. In this context several biomarkers are differentially regulated by antidepressant treatment and connected to metabolic, inflammatory, cardiovascular and apoptotic components of the pathophysiology, i...
October 17, 2017: Neuro-Signals
https://www.readbyqxmd.com/read/29039510/homocysteine%C3%A2-induced-oxidative-stress-through-tlr4-nf%C3%A2-%C3%AE%C2%BAb-dnmt1%C3%A2-mediated-lox%C3%A2-1-dna-methylation-in-endothelial-cells
#8
Sheng-Chao Ma, Yin-Ju Hao, Yun Jiao, Yan-Hua Wang, Ling-Bo Xu, Cai-Yan Mao, Xiao-Ling Yang, An-Ning Yang, Jue Tian, Ming-Hao Zhang, Shao-Ju Jin, Hua Xu, Yi-Deng Jiang, Hui-Ping Zhang
Atherosclerosis (AS) is a progressive disease of multifactorial origin, which occurs in response to endothelial injury. Increased homocysteine (Hcy) is considered a major cause of endothelial dysfunction, oxidative stress and DNA methylation; however, the mechanisms remain to be fully elucidated. The aim of the present study was to investigate whether Hcy causes injury to endothelial cells (ECs) by the effect of lectin‑like oxidized‑low density lipoprotein receptor‑1 (LOX‑1) DNA methylation through toll‑like receptor 4(TLR4)/nuclear factor (NF)‑κB/DNA methyltransferase (DNMT)1...
October 10, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29038593/gender-and-lesion-number-dependent-difference-in-atherogenic-index-of-plasma-in-chinese-people-with-coronary-heart-disease
#9
Wei Ni, Zhenyu Zhou, Tao Liu, Haoyu Wang, Jianping Deng, Xiaoyan Liu, Guoqiang Xing
Few studies has investigated the interrelationship between Atherogenic index of plasma (AIP) and coronary heart disease (CHD) especially in Asians. AIP is the logarithmically transformed ratio of triglyceride (TG) to high-density lipoprotein cholesterol (HDL-C), and is thought to be associated with arteriosclerosis, hypertension, diabetes and cardiovascular diseases. Of the 463 patients from Central Hospital of Nanchong in 2011-2014 diagnosed with angiograms, 229 CHD (>50% stenosis in one or more arteries) and the rest 234 were the controls (maximum stenosis < 10% in any artery) according to the world health organization (who) diagnostic criteria...
October 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29037490/alzheimer-s-disease-pathogenesis-is-there-a-role-for-folate
#10
REVIEW
Natassia Robinson, Peter Grabowski, Ishtiaq Rehman
Epigenetic modifications, including changes in DNA methylation, have been implicated in a wide range of diseases including neurological diseases such as Alzheimer's. The role of dietary folate in providing methyl groups required for maintenance and modulation of DNA methylation makes it a nutrient of interest in Alzheimer's. Late onset Alzheimer's disease is the most common form of dementia and at present its aetiology is largely undetermined. From epidemiological studies, the interactions between folate, B-vitamins and homocysteine as well as the long latency period has led to difficulties in interpretation of the data, thus current evidence exploring the role of dietary folate in Alzheimer's is contradictory and unresolved...
October 13, 2017: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/29035128/prospective-study-of-plasma-homocysteine-its-dietary-determinants-and-risk-of-age-related-macular-degeneration-in-men
#11
William G Christen, Nancy R Cook, Stephanie E Chiuve, Paul M Ridker, J Michael Gaziano
PURPOSE: Cross-sectional and case-control studies generally support a direct association between elevated plasma homocysteine and age-related macular degeneration (AMD), but data from prospective studies are limited. We examined the prospective relation of plasma homocysteine level, its dietary determinants, and risk of AMD in a large cohort of apparently healthy male physicians. METHODS: During a mean follow-up of 11.2 years, we identified 146 incident cases of visually significant AMD (responsible for a reduction of visual acuity to 20/30 or worse), and 146 controls matched for age, smoking status, and time of blood draw...
October 16, 2017: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/29032752/association-between-apolipoproteins-ai-and-b-and-ultrasound-indicators-of-carotid-atherosclerosis
#12
Zeljko Zivanovic, Ivana Divjak, Mirjana Jovicevic, Tamara Rabi-Zikic, Biljana Radovanovic, Svetlana Ruzicka-Kaloci, Djordje Stevan Popovic, Edita Stokic, Ksenija Gebauer-Bukurov, Katarina Zivanovic-Vujcic, Petar Slankamenac
BACKGROUND: Apolipoproteins A-I and B (apoA-I and apoB) may be better indicators of the risk of cardiovascular and cerebrovascular diseases than conventional risk factors (RFs). The onset of ischemic stroke (IS) may be preceded by the development of atherosclerotic changes in carotid arteries, which can be detected by ultrasound. Only a certain % of patients with IS have an (underlying) carotid etiology. OBJECTIVE: The aim of our study was to determine the association between ultrasound indicators of carotid atherosclerosis and the presence of apolipoproteins and other biomarkers in patients with IS...
October 10, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/29032242/combination-of-vitamin-b12-active-forms-improved-fetal-growth-in-wistar-rats-through-up-regulation-of-placental-mir-16-and-mir-21-levels
#13
Tejas Shah, Sanjay Mishra, Amol More, Suhas Otiv, Kishori Apte, Kalpana Joshi
Aim Epidemiological studies have indicated importance of folate and vitamin (B12) during pregnancy. Also available evidence on efficacy of B12 forms viz. Cyanocobalamin (Cbl), Methylcobalamin (MeCbl), Adenosylcobalamin (AdCbl) and Hydroxycobalamin (HCbl) in preventing or treating cobalamin deficiency is limited. The present study examines the effect of various B12 forms in combination with folate during pregnancy and their effect on gestational outcomes. MAIN METHOD: In the present study, we examined the effect of various vitamin B12 forms in presence of recommended folate (RFol: 400μg/day) and high folate (HFol: 5mg/day) on gestational outcomes in female Wistar rats...
October 12, 2017: Life Sciences
https://www.readbyqxmd.com/read/29030456/association-between-percent-decline-in-serum-total-homocysteine-and-risk-of-first-stroke
#14
Xiao Huang, Youbao Li, Ping Li, Jianping Li, Huihui Bao, Yan Zhang, Binyan Wang, Ningling Sun, Jiguang Wang, Mingli He, Delu Yin, Genfu Tang, Yundai Chen, Yiming Cui, Yining Huang, Fan Fan Hou, Xianhui Qin, Yong Huo, Xiaoshu Cheng
OBJECTIVE: To examine whether a change in serum total homocysteine (tHcy) levels is associated with first stroke risk in a post hoc analysis of the China Stroke Primary Prevention Trial (CSPPT). METHODS: We analyzed 16,867 participants of the CSPPT with tHcy measurements at both baseline and exit visits. The primary outcome was first stroke. The secondary outcome was a composite of cardiovascular events consisting of cardiovascular death, myocardial infarction, and stroke...
October 13, 2017: Neurology
https://www.readbyqxmd.com/read/29029082/decreased-homocysteine-trans-sulfuration-in-hypertension-with-hyperhomocysteinemia-relationship-with-insulin-resistance
#15
Paolo Tessari, Monica Vettore, Lucia Puricelli, Diego Cecchet, Anna Coracina, Edward Kivanuka
Context: Homocysteine is an independent cardiovascular risk factor and is increased in essential hypertension. Insulin stimulates homocysteine catabolism in healthy individuals. However, the mechanisms of hyperhomocysteinemia and its relationship with insulin resistance in essential hypertension are unknown. Objective: To investigate whole-body methionine and homocysteine kinetics, and the effects of insulin, in essential hypertension. Design & Setting: Eight hypertensive male subjects, and six male normotensive controls, were infused with L-[methyl-2H3,1-13C]methionine for 6 hrs...
September 29, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29026499/comparison-between-homocysteine-fibrinogen-pt-ptt-inr-and-crp-in-male-smokers-with-without-addiction-to-opium
#16
Nahid Azdaki, Mahmood Zardast, Gholamreza Anani-Sarab, Hamid Abdorrazaghnaejad, Mohammad Reza Ghasemian, Amin Saburi
BACKGROUND: Regarding the limited studies about effects of addiction on coagulation factors as a risk factor for increasing coagulation, and its relation to coronary artery disease, we decided to investigate the effect of opium on inflammatory and coagulation factors in a controlled setting. METHODS: This case-control study was performed using two groups of smoking males addicted to opium (27 cases) and not addicted to opium (27 cases). After collecting demographic data, venous blood samples were gathered and sent to laboratory for measuring homocysteine, fibrinogen, prothrombin time (PT), partial thromboplastin time (PTT), International Normalized Ratio (INR), and C-reactive protein (CRP) quantity...
January 2017: Addiction & Health
https://www.readbyqxmd.com/read/29026158/ginsenoside-rb1-prevents-homocysteine-induced-epc-dysfunction-via-vegf-p38mapk-and-sdf-1-cxcr4-activation
#17
Tao-Hua Lan, Dan-Ping Xu, Man-Ting Huang, Ju-Xian Song, Huan-Lin Wu, Min Li
Hyperhomocystinemia (HHcy) is known as an independent risk factor for cardiovascular disease. Our previous study showed that ginsenoside Rb1, the major active constituent of ginseng, prevents homocysteine (Hcy)-induced endothelial damage. However, the role of ginsenoside Rb1 in Hcy-induced dysfunction in endothelial progenitor cells (EPCs) remains unknown. In the study, we found that ginsenoside Rb1 reversed the Hcy-induced impairment of adhesive and migratory ability in EPCs which were significantly abolished by CXCR4 antagonist AMD3100 and VEGFR2 inhibitor SU5416...
October 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29024723/homocysteine-concentrations-in-the-cognitive-progression-of-alzheimer-s-disease
#18
Nicolas Farina, Fredrik Jernerén, Cheryl Turner, Kathryn Hart, Naji Tabet
OBJECTIVES: Hyperhomocysteinemia in Alzheimer's disease (AD) is widely reported and appears to worsen as the disease progresses. While active dietary intervention with vitamins B12 and folate decreases homocysteine blood levels, with promising clinical outcomes in Mild Cognitive Impairment (MCI), this so far has not been replicated in established AD populations. The aim of the study is to explore the relationship between hyperhomocystenemia and relevant vitamins as the disease progresses...
October 10, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/29024618/association-of-serum-asymmetric-dimethylarginine-homocysteine-and-l-arginine-concentrations-during-early-pregnancy-with-hypertensive-disorders-of-pregnancy
#19
Ei Maruta, Jingwen Wang, Tomomi Kotani, Hiroyuki Tsuda, Tomoko Nakano, Kenji Imai, Seiji Sumigama, Yoshimitsu Niwa, Takashi Mitsui, Shigeru Yoshida, Mamoru Yamashita, Akihiro Nawa, Koji Tamakoshi, Hiroaki Kajiyama, Fumitaka Kikkawa
BACKGROUND: Our previous study suggested that a lower l-arginine level (<70μM) at early gestation is associated with pregnancy-induced hypertension. The maternal asymmetric dimethylarginine (ADMA) and homocysteine (Hcy) concentrations also have been reported to be increased in hypertensive disorders of pregnancy (HDP). These molecules have a key role in metabolism of nitric oxide. The aim of this study is to determine the most useful predictor of HDP at early gestation. METHODS: The concentrations of ADMA and Hcy at each of three periods in normal pregnancy were determined, and the values compared between the normal pregnancy and HDP groups...
October 9, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29024304/efficacy-of-alprostadil-in-preventing-contrast-induced-nephropathy-in-patients-undergoing-percutaneous-coronary-intervention-a-multicenter-prospective-randomized-controlled-trial
#20
Min Liang, Shicheng Yang, Naikuan Fu, Chengzhi Lu, Fengshi Tian, Xiaochun Xing, Wenhua Lin, Jingjing Liu
BACKGROUND: The role of alprostadil on the prevention of contrast-induced nephropathy (CIN) still remains controversial. The purpose of this study was to examine the effects of short-term alprostadil on the incidence of CIN in patients undergoing elective percutaneous coronary intervention (PCI). METHODS: A total of 480 patients with coronary heart disease undergoing PCI were enrolled in our study and randomly assigned to two groups. The control group (n = 240) was given only hydration therapy and the alprostadil group (n = 240) received intravenous administration of 20 ug/day (diluted with 100 ml normal saline) from 0...
October 10, 2017: Catheterization and Cardiovascular Interventions
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