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https://www.readbyqxmd.com/read/28215051/-pro-renin-receptor-atp6ap2-depletion-arrests-as4-1-cells-in-the-g0-g1-phase-thereby-increasing-formation-of-primary-cilia
#1
Heike Wanka, Philipp Lutze, Doreen Staar, Barbara Peters, Anica Morch, Lukas Vogel, Ravi Kumar Chilukoti, Georg Homuth, Jaroslaw Sczodrok, Inga Bäumgen, Jörg Peters
The (pro)renin receptor [(P)RR, ATP6AP2] is a multifunctional transmembrane protein that activates local renin-angiotensin systems, but also interacts with Wnt pathways and vacuolar H(+) -ATPase (V-ATPase) during organogenesis. The aim of this study was to characterize the role of ATP6AP2 in the cell cycle in more detail. ATP6AP2 down-regulation by siRNA in renal As4.1 cells resulted in a reduction in the rate of proliferation and a G0/G1 phase cell cycle arrest. We identified a number of novel target genes downstream of ATP6AP2 knock-down that were related to the primary cilium (Bbs-1, Bbs-3, Bbs-7, Rabl5, Ttc26, Mks-11, Mks-5, Mks-2, Tctn2, Nme7) and the cell cycle (Pierce1, Clock, Ppif)...
February 19, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28208327/issues-associated-with-galilean-invariance-on-a-moving-solid-boundary-in-the-lattice-boltzmann-method
#2
Cheng Peng, Nicholas Geneva, Zhaoli Guo, Lian-Ping Wang
In lattice Boltzmann simulations involving moving solid boundaries, the momentum exchange between the solid and fluid phases was recently found to be not fully consistent with the principle of local Galilean invariance (GI) when the bounce-back schemes (BBS) and the momentum exchange method (MEM) are used. In the past, this inconsistency was resolved by introducing modified MEM schemes so that the overall moving-boundary algorithm could be more consistent with GI. However, in this paper we argue that the true origin of this violation of Galilean invariance (VGI) in the presence of a moving solid-fluid interface is due to the BBS itself, as the VGI error not only exists in the hydrodynamic force acting on the solid phase, but also in the boundary force exerted on the fluid phase, according to Newton's Third Law...
January 2017: Physical Review. E
https://www.readbyqxmd.com/read/28174475/correlation-among-proprioception-muscle-strength-and-balance
#3
Huihui Wang, Zhongqiu Ji, Guiping Jiang, Weitong Liu, Xibian Jiao
[Purpose] To study the correlation among proprioception, muscle strength, and balance. [Subjects and Methods] A balance testing system (Biodex Balance System, BBS) and an isokinetic testing system (Biodex System 4, BS4) were used to test related indexes in 24 healthy young females. [Results] With the knee joint at 15 degree flexion, proprioception was significantly correlated with Limits of Stability-Time values, and was highly significantly correlated with Limits of Stability-Overall and Athlete Single Leg Medial/Lateral values...
December 2016: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28174431/the-effect-of-walking-sticks-on-balance-in-geriatric-subjects
#4
Esra Dogru, Harun Kizilci, Nilay Comuk Balci, Nilufer Cetisli Korkmaz, Ozden Canbay, Nihan Katayifci
[Purpose] Guidelines and clarity regarding the information for deciding the need for walking sticks and the suitability of these sticks is insufficient. This study aimed to evaluate the suitability of walking stick and its effects on the balance in the elderly. [Subjects and Methods] A total of 39 elderly subjects aged between 65-95 years (mean age, 76.15 ± 8.35 years) and living in the Residential Aged Care and Rehabilitation Center were included. Sociodemographic data of the individuals, the material of the walking stick, who made the decision of usage and length of walking sticks were questioned...
December 2016: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28167476/research-on-the-influence-factors-of-the-fall-efficiency-of-the-hospitalized-geriatric-patients-with-cerebrovascular-diseases
#5
Weili Li, Ruilian Cheng
To investigate the fall efficiency and its influence factors of the hospitalized geriatric patients with cerebrovascular diseases. The Modified Fall Efficacy Scale (MFES), Morse Fall Risk Assessment Scales (MFS), Berg Balance Scale (BBS) and Tinetti Gait Analysis (TGA) were adopted and the combined ways of questionnaires and observation were utilized to investigate the 113 hospitalized geriatric patients with cerebrovascular diseases. The fall efficiency of the geriatric patients with cerebrovascular diseases were 7...
November 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28167167/nintendo-wii-fit-for-balance-rehabilitation-in-patients-with-parkinson-s-disease-a-comparative-study
#6
Stefano Negrini, Luciano Bissolotti, Alessandro Ferraris, Fulvia Noro, Mark D Bishop, Jorge Hugo Villafañe
BACKGROUND: Impaired postural stability places individuals with Parkinson's disease (PD) at an increased risk for falls. OBJECTIVE: We evaluated the effectiveness of 10 vs. 15 sessions of Nintendo Wii Fit for balance recovery for outpatients PD. METHODS: Twenty-seven patients, 48.1% female (66 ± 8 years), with PD. Patients with PD were consecutively assigned to one of two groups receiving either 10 or 15 sessions (low dose or high dose group, respectively) with Nintendo Wii Fit in recovering balancing ability...
January 2017: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/28158197/rehabilitation-in-progressive-supranuclear-palsy-effectiveness-of-two-multidisciplinary-treatments
#7
Ilaria Clerici, Davide Ferrazzoli, Roberto Maestri, Fabiola Bossio, Ilaria Zivi, Margherita Canesi, Gianni Pezzoli, Giuseppe Frazzitta
BACKGROUND: to date, there are no medical or surgical treatments for progressive supranuclear palsy (PSP). It is possible to speculate that patients with PSP could benefit from rehabilitative treatments designed for Parkinson's disease, including the use of robot-assisted walking training. OBJECTIVE: to evaluate whether the use of the robotic device Lokomat® is superior in PSP patients to the use of treadmill with visual cues and auditory feedbacks (treadmill-plus) in the context of an aerobic, multidisciplinary, intensive, motor-cognitive and goal-based rehabilitation treatment (MIRT) conceived for Parkinsonian patients...
2017: PloS One
https://www.readbyqxmd.com/read/28143435/genetic-characterization-of-italian-patients-with-bardet-biedl-syndrome-and-correlation-to-ocular-renal-and-audio-vestibular-phenotype-identification-of-eleven-novel-pathogenic-sequence-variants
#8
Gabriella Esposito, Francesco Testa, Miriam Zacchia, Anna Alessia Crispo, Valentina Di Iorio, Giovanna Capolongo, Luca Rinaldi, Marcella D'Antonio, Tiziana Fioretti, Pasquale Iadicicco, Settimio Rossi, Annamaria Franzè, Elio Marciano, Giovanbattista Capasso, Francesca Simonelli, Francesco Salvatore
BACKGROUND: Bardet-Biedl syndrome (BBS) is a rare genetic disorder that features retinal degeneration, obesity, polydactyly, learning disabilities and renal abnormalities. The diagnosis is often missed at birth, the median age at diagnosis being 9 years. In the attempt to shed light on BBS and improve its diagnosis and treatment, we evaluated the genotype-phenotype relationship in patients with a molecular diagnosis of BBS. METHODS: We analyzed three common BBS genes, BBS1, BBS10 and BBS2, in 25 Italian patients fulfilling the clinical criteria of BBS...
February 1, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/28137928/efficiency-of-physical-therapy-on-postural-imbalance-after-stroke-study-protocol-for-a-systematic-review-and-meta-analysis
#9
A Hugues, J Di Marco, P Janiaud, Y Xue, J Pires, H Khademi, M Cucherat, I Bonan, F Gueyffier, G Rode
INTRODUCTION: Stroke frequently results in balance disorders, leading to lower levels of activity and a diminution in autonomy. Current physical therapies (PT) aiming to reduce postural imbalance have shown a large variety of effects with low levels of evidence. The objectives are to determine the efficiency of PT in recovering from postural imbalance in patients after a stroke and to assess which PT is more effective. METHODS AND ANALYSIS: We will search several databases from inception to October 2015...
January 30, 2017: BMJ Open
https://www.readbyqxmd.com/read/28126172/effect-of-%C3%AE-blocker-on-aneurysm-sac-behavior-after-endovascular-abdominal-aortic-repair
#10
Wonho Kim, Ripal T Gandhi, Constantino S Peña, Raul E Herrera, Melanie B Schernthaner, Athanassios Tsoukas, Juan M Acuña, Barry T Katzen
OBJECTIVE: This study was conducted to determine whether β-blocker (BB) therapy is associated with abdominal aortic aneurysm (AAA) sac regression after endovascular abdominal aortic repair (EVAR). METHODS: A total of 198 patients (mean age, 76 years) who underwent EVAR were analyzed (104 in the BB group and 94 in the non-BB group). The primary end point was the incidence of AAA sac regression at 1 and 2 years. RESULTS: Hypertension, coronary artery disease, and hyperlipidemia were more common in the BB group...
February 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28119837/comparison-of-balance-proprioception-and-skeletal-muscle-mass-in-total-hip-replacement-patients-with-and-without-fracture-a-pilot-study
#11
Seunghwi Jo, Si-Bog Park, Mi Jung Kim, Taikon Kim, Kyeong Il Park, Junhyun Sung, Un Jin Park, Yee Suk Kim, Byeong Jik Kang, Kyu Hoon Lee
OBJECTIVE: To determine whether there was a difference in balance, proprioception, and skeletal muscle mass among patients who undergo hip fracture surgery relative to and elective total hip replacement (THR). METHODS: Thirty-one THR patients were enrolled. The patients were categorized into two groups: fracture group (n=15) and non-fracture group (n=16). Berg Balance Scale (BBS) was used to balance the proprioception of the hip joint while a joint position sense (JPS) test was used to evaluate it...
December 2016: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/28119826/effects-of-3-dimensional-lumbar-stabilization-training-for-balance-in-chronic-hemiplegic-stroke-patients-a-randomized-controlled-trial
#12
Jin-Young Chun, Jeong-Hwan Seo, Sung-Hee Park, Yu Hui Won, Gi-Wook Kim, Sung-Jun Moon, Myoung-Hwan Ko
OBJECTIVE: To investigate the effects of the newly developed Spine Balance 3D system on the balance and gait abilities of hemiplegic stroke patients. METHODS: Twenty-eight hemiplegic patients with chronic stroke were randomly assigned to an experimental (n=14) or control group (n=14). The experimental and control groups performed balance training by using the newly developed Spine Balance 3D system and the well-known Biodex Balance System 30 minutes per day, three times a week for 7 weeks...
December 2016: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/28102113/comparison-of-the-effects-on-dynamic-balance-and-aerobic-capacity-between-objective-and-subjective-methods-of-high-intensity-robot-assisted-gait-training-in-chronic-stroke-patients-a-randomized-controlled-trial
#13
Young-Hyeon Bae, Suck Min Lee, Mansoo Ko
BACKGROUND: Robot-assisted gait training (RAGT) is effective for improving dynamic balance and aerobic capacity, but previous RAGT method does not set suitable training intensity. Recently, high-intensity treadmill gait training at 70% of heart rate reserve (HRR) was used for improving aerobic capacity and dynamic balance. PURPOSE: This study was designed to compare the effectiveness between objective and subjective methods of high-intensity RAGT for improving dynamic balance and aerobic capacity in chronic stroke...
January 19, 2017: Topics in Stroke Rehabilitation
https://www.readbyqxmd.com/read/28101303/efficacy-of-multiple-biliary-stenting-for-refractory-benign-biliary-strictures-due-to-chronic-calcifying-pancreatitis
#14
Hiroshi Ohyama, Rintaro Mikata, Takeshi Ishihara, Yuji Sakai, Harutoshi Sugiyama, Shin Yasui, Toshio Tsuyuguchi
AIM: To investigate endoscopic therapy efficacy for refractory benign biliary strictures (BBS) with multiple biliary stenting and clarify predictors. METHODS: Ten consecutive patients with stones in the pancreatic head and BBS due to chronic pancreatitis who underwent endoscopic therapy were evaluated. Endoscopic insertion of a single stent failed in all patients. We used plastic stents (7F, 8.5F, and 10F) and increased stents at intervals of 2 or 3 mo. Stents were removed approximately 1 year after initial stenting...
January 16, 2017: World Journal of Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28090182/supervised-versus-home-exercise-training-programs-on-functional-balance-in-older-subjects
#15
Enas Fawzy Youssef, Alsayed Abd Elhameed Shanb
BACKGROUND: Aging is associated with a progressive decline in physical capabilities and a disturbance of both postural control and daily living activities. The aim of this study was to evaluate the effects of supervised versus home exercise programs on muscle strength, balance and functional activities in older participants. METHODS: Forty older participants were equally assigned to a supervised exercise program (group-I) or a home exercise program (group-II). Each participant performed the exercise program for 35-45 minutes, two times per week for four months...
November 2016: Malaysian Journal of Medical Sciences: MJMS
https://www.readbyqxmd.com/read/28079635/influences-of-age-obesity-and-adverse-drug-effects-on-balance-and-mobility-testing-scores-in-ambulatory-older-adults
#16
Eric Anson, Elizabeth Thompson, Brian L Odle, John Jeka, Zachary F Walls, Peter C Panus
BACKGROUND AND PURPOSE: The adverse effects of drugs may influence results on tests of mobility and balance, but the drug-specific impact is not identified when using these tests. We propose that a quantitative drug index (QDI) will assist in assessing fall risk based on these tests, when combined with other fall risk variables. METHODS: Fifty-seven community-dwelling older adults who could walk independently on a treadmill and had Mini-Mental State Examination (MMSE) scores equal to or greater than 24 participated...
January 10, 2017: Journal of Geriatric Physical Therapy
https://www.readbyqxmd.com/read/28070922/an-open-label-randomized-control-trial-of-hopping-and-jumping-training-versus-sensorimotor-rehabilitation-programme-on-postural-capacities-in-individuals-with-intellectual-disabilities
#17
Rihab Borji, Sonia Sahli, Rym Baccouch, Rabeb Laatar, Hiba Kachouri, Haithem Rebai
BACKGROUND: This study aimed to compare the effectiveness of a hopping and jumping training programme (HJP) versus a sensorimotor rehabilitation programme (SRP) on postural performances in children with intellectual disability. METHODS: Three groups of children with intellectual disability participated in the study: the HJP group, the SRP group and a control group. Postural capacities were tested with the Berg Balance Scale (BBS) and the Tinetti tests. The HJP and the SRP groups participated in the training programmes for eight weeks...
January 10, 2017: Journal of Applied Research in Intellectual Disabilities: JARID
https://www.readbyqxmd.com/read/28048771/su-f-j-37-commissioning-a-six-degree-of-freedom-couch
#18
D Roberts, K Lam, J Bredfeldt, E Covington
PURPOSE: The proper operation of a six degree of freedom couch (6DOFC) to position a patient for treatment requires that a number systems on the treatment unit work together correctly. Commissioning a 6DOFC requires not only the commissioning of each separate system but also commissioning the interactions between the systems. METHODS: To commission a 6DOFC, we tested the resolvers that readout the linear and angular positions; the orthogonality of the axes of the laser positioning system, the imaging system, the gantry and the couch as well as their relationship to each other...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046920/su-f-j-188-clinical-implementation-of-in-room-mobile-ct-for-image-guided-proton-therapy
#19
H Li, R Wu, F Poenisch, L Zhang, M Palmer, A Gautam, N Sahoo, X Zhang, P Balter, M Gillin, B Gunn, S Frank, X Zhu
PURPOSE: To implement soft-tissue image-guided proton therapy using inroom mobile CT. METHODS: Anthropomorphic phantom was first used to determine the setup accuracy using in- room mobile CT. Laser and bbs were used for the initial setup (marked isocenter). CT data was then acquired with in-room mobile CT (daily CT). The shift between the marked isocenter and the planned isocenter (final isocenter) was determined from the daily CT using in-house Computer Assisted Targeting (CAT) software...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28044398/examining-the-validity-and-sensitivity-to-change-of-the-5-and-10-sit-to-stand-tests-in-people-with-multiple-sclerosis
#20
Ylva Nilsagård, Malin Andreasson, Anna Carling, Helena Vesterlin
BACKGROUND AND PURPOSE: Sit-to-stand transfers are frequently performed, and transfers have been associated with fall risk among people with multiple sclerosis (PwMS). There is limited research regarding the validity of sit-to-stand tests (STSs) in PwMS. The purpose of this study was to investigate the concurrent, divergent, and discriminant validity and sensitivity to change of the 5 and 10 STSs. METHODS: A repeated-measurement design was used, with data collected before and directly after a 7-week intervention, as well as prospectively reported near-fall incidents and falls during a 14-week period...
January 3, 2017: Physiotherapy Research International: the Journal for Researchers and Clinicians in Physical Therapy
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