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https://www.readbyqxmd.com/read/29792395/how-are-patients-with-heart-failure-treated-in-primary-care
#1
Hélène Vaillant-Roussel, Bruno Pereira, Sylvaine Gibot-Boeuf, Romain Eschalier, Claude Dubray, Rémy Boussageon, Philippe Vorilhon
OBJECTIVE: The aim of this study was to assess the adherence of general practitioners (GPs) to guidelines in patients with heart failure with reduced ejection fraction (HFrEF) and to describe GPs' prescribing behavior regarding patients with heart failure with preserved ejection fraction (HFpEF). MATERIALS AND METHODS: Cross-sectional study as part of the ETIC trial. Five classes of drugs were described: angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs); β-blockers (BBs); mineralocorticoid receptor antagonists (MRAs); diuretics (thiazide or loop diuretics); and digoxin...
May 24, 2018: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29768548/balance-functional-mobility-and-fall-occurrence-in-patients-with-human-t-cell-lymphotropic-virus-type-1-associated-myelopathy-tropical-spastic-paraparesis-a-cross-sectional-study
#2
Erika Pedreira da Fonseca, Katia Nunes Sá, Rebeca Freitas Reis Nunes, Antônio Carlos Ribeiro Junior, Síntia Freitas Bastos Lira, Elen Beatriz Pinto
INTRODUCTION: Human T-cell lymphotropic virus type-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) may lead to reduced functional mobility and balance. It is important to establish specific parameters that identify these changes and predict the risk of falls in these patients. The aim was to compare balance, functional mobility, and occurrence of falls among patients with and without HAM/TSP and to suggest values to predict the risk of falls in these patients. METHODS: A cross-sectional study in patients with and without HAM/TSP involved balance assessments based on the berg balance scale (BBS) and functional mobility evaluation based on the timed up and go (TUG) test...
March 2018: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29767392/a-novel-rabbit-model-for-benign-biliary-stricture-formation-and-the-effects-of-medication-infusions-on-stricture-formation
#3
Qin Yang, Junke Wang, Fei Liu, Wenjie Ma, Haijie Hu, Congdun Ran, Fuyu Li, Qiuwei Pan
BACKGROUND: Benign biliary stricture (BBS) is highly refractory. Currently, there is no effective strategy for prevention of BBS recurrence. The aim of this study is to establish a novel BBS rabbit model and to investigate the efficacy of biliary infusion with anti-proliferative medications for treating BBS. METHOD: A BBS model was established via surgical injury and biliary infection. The biliary infusion tube was inserted into the common bile duct via the stump of cystic duct after cholecystectomy...
May 16, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29767227/effect-of-a-balance-training-programme-on-postural-balance-aerobic-capacity-and-frequency-of-falls-in-women-with-osteoporosis-a-randomized-controlled-trial
#4
Ibolya Miko, Imre Szerb, Anna Szerb, Tamas Bender, Gyula Poor
OBJECTIVE: To investigate the effect of a 12-month complex balance-training programme on static and dynamic postural balance, aerobic capacity and frequency of falls in women with established osteoporosis. DESIGN: Randomized controlled trial in which the intervention group was assigned a 12-month exercise programme (3 times a week for 30 min) and the control group had no intervention. SUBJECTS: A total of 100 osteoporotic women with at least one previous fracture...
May 16, 2018: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29765180/effects-of-circular-gait-training-on-balance-balance-confidence-in-patients-with-stroke-a-pilot-study
#5
Shin-Kyu Park, Sung-Jin Kim, Tak Yong Yoon, Suk-Min Lee
[Purpose] This study aimed to investigate the effects of circular gait training on balance and balance confidence in patients with stroke. [Subjects and Methods] Fifteen patients with stroke were randomly divided into either the circular gait training (CGT) group (n=8) or the straight gait training (SGT) group (n=7). Both groups had conventional therapy that adhered to the neurodevelopmental treatment (NDT) approach, for 30 min. In addition, the CGT group performed circular gait training, and the SGT group practiced straight gait training for 30 min...
May 2018: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/29761930/multiple-phosphorylation-sites-on-%C3%AE-tubulin-are-essential-and-contribute-to-the-biogenesis-of-basal-bodies-in-tetrahymena
#6
Ewa Joachimiak, Maria Jerka-Dziadosz, Łucja Krzemień-Ojak, Ewa Wacławek, Katarzyna Jedynak, Paulina Urbanska, Wojciech Brutkowski, Hanna Sas-Nowosielska, Hanna Fabczak, Jacek Gaertig, Dorota Wloga
The mechanisms that regulate γ-tubulin, including its post-translational modifications, are poorly understood. γ-Tubulin is important for the duplication of centrioles and structurally similar basal bodies (BBs), organelles which contain a ring of nine triplet microtubules. The ciliate Tetrahymena thermophila carries hundreds of cilia in a single cell and provides an excellent model to specifically address the role of γ-tubulin in the BBs assembly and maintenance. The genome of Tetrahymena contains a single γ-tubulin gene...
May 15, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29754569/toward-personalized-medicine-in-bardet-biedl-syndrome
#7
Joanna Kenny, Elizabeth Forsythe, Philip Beales, Chiara Bacchelli
Personalized medicine is becoming routine in the treatment of common diseases such as cancer, but has lagged behind in the field of rare diseases. It is currently in the early stages for the treatment of Bardet-Biedl syndrome. Advances in the understanding of ciliary biology and diagnostic techniques have opened up the prospect of treating BBS in a patient-specific manner. Owing to their structure and function, cilia provide an attractive therapeutic target and genetic therapies are being explored in ciliopathy treatment...
September 2017: Personalized Medicine
https://www.readbyqxmd.com/read/29753704/effect-of-the-auricular-accupoint-associated-to-physical-exercise-in-elderly-people-a-randomized-clinical-test
#8
Rogéria Gonçalves de Carvalho Fonseca, Andreia Maria Silva, Luiza Faria Teixeira, Valéria Regina Silva, Luciana Maria Dos Reis, Adriana Teresa Silva Santos
OBJECTIVE: To analyze the effect of auricular acupoint associated with physical exercise on balance, mobility and fear of falling in the elderly. METHOD: The study is characterized as a clinical, controlled and randomized trial with 22 elderly sampled divided into two groups: kinesiotherapy group (KG, n = 11) and kinesiotherapy/auriculotherapy group (AKG, n = 11). The instruments used for evaluation were Falls Efficacy Scale International (FES-I); Berg Balance Scale (BBS) and Timed up and Go Test (TUG)...
May 10, 2018: Journal of Acupuncture and Meridian Studies
https://www.readbyqxmd.com/read/29749561/use-of-carbon-steel-ball-bearings-to-determine-the-effect-of-biocides-and-corrosion-inhibitors-on-microbiologically-influenced-corrosion-under-flow-conditions
#9
Tijan Pinnock, Johanna Voordouw, Gerrit Voordouw
A consortium of sulfate-reducing bacteria consisting mostly of Desulfovibrio, Desulfomicrobium, and Desulfocurvus from oil field produced water was cultivated in a chemostat, receiving medium with 20 mM formate and 10 mM sulfate as the energy and 1 mM acetate as the carbon source. The chemostat effluent, containing 5 mM sulfide and 0.5 mM of residual acetate, was passed through 1-ml syringe columns with 60 carbon steel ball bearings (BBs) of 53.6 ± 0.1 mg each at a flow rate of 0.8 ml/h per column...
May 10, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29748973/afm-nano-mechanical-study-of-the-beating-profile-of-hipsc-derived-cardiomyocytes-beating-bodies-wt-and-dm1
#10
S Dinarelli, M Girasole, P Spitalieri, R V Talarico, M Murdocca, A Botta, G Novelli, R Mango, F Sangiuolo, G Longo
Myotonic Dystrophy type 1 (DM1) is the most common form of muscular dystrophy in adults, characterized by a variety of multisystemic features and associated with cardiac anomalies. Among cardiac phenomena, conduction defects, ventricular arrhythmias, and dilated cardiomyopathy represent the main cause of sudden death in DM1 patients. Patient-specific induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) represent a powerful in vitro model for molecular, biochemical, and physiological studies of disease in the target cells...
May 10, 2018: Journal of Molecular Recognition: JMR
https://www.readbyqxmd.com/read/29747861/effects-of-carvedilol-versus-metoprolol-on-platelet-aggregation-in-patients-with-acute-coronary-syndrome-the-plate-block-study
#11
Federica Ilardi, Giuseppe Gargiulo, Gabriele Giacomo Schiattarella, Giuseppe Giugliano, Roberta Paolillo, Giovanni Menafra, Elena De Angelis, Laura Scudiero, Anna Franzone, Eugenio Stabile, Cinzia Perrino, Plinio Cirillo, Carmine Morisco, Raffaele Izzo, Valentina Trimarco, Giovanni Esposito
Platelet aggregation plays a pivotal role in acute coronary syndrome (ACS). In this setting, β-blockers (BBs) are used to counteract the effects of catecholamines on heart. Circulating catecholamines can also potentiate platelet reactivity, mainly through α2 - and β2 -adrenoceptors on human platelets' surface, thus BB may affect platelet aggregation; however, the effects of different BBs on platelet aggregation in contemporary-treated patients with ACS have been poorly investigated. One hundred patients with ACS on dual antiplatelet therapy with aspirin and ticagrelor were randomized to receive treatment with carvedilol, a nonselective BB (n = 50), or metoprolol, a selective β1 -blocker (n = 50), at maximum tolerated dose...
April 3, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29736314/detection-of-early-stage-extrahepatic-cholangiocarcinoma-in-patients-with-biliary-strictures-by-soluble-b7-h4-in-the-bile
#12
Wenbo Ke, Li Zeng, Yunbi Hu, Sisi Chen, Min Tian, Qinggang Hu
Increasing evidence has demonstrated that serum soluble B7-H4 (sB7-H4) is a useful tumour marker for cancer diagnosis and prognosis evaluation. Whether sB7-H4 is expressed in the bile of cholangiocarcinoma (CC) and is related to the progression of CC need to be explored. Bile sB7-H4 was obtained through endoscopic retrograde cholangiopancreatography (ERCP) from 213 patients with biliary strictures and detected was detected by a B7-H4 ELISA kit. Diagnostic value was compared among bile sB7-H4, CA19-9, CA12-5, CEA and ERCP-based cytological/tissue examination...
2018: American Journal of Cancer Research
https://www.readbyqxmd.com/read/29718777/effects-of-a-12-month-task-specific-balance-training-on-the-balance-status-of-stroke-survivors-with-and-without-cognitive-impairments-in-selected-hospitals-in-nnewi-anambra-state-nigeria
#13
Uchenna Prosper Okonkwo, Sam Chidi Ibeneme, Ebere Yvonne Ihegihu, Afamefuna Victor Egwuonwu, Charles Ikechukwu Ezema, Fatai Adesina Maruf
BACKGROUND: Stroke results in varying levels of physical disabilities that may adversely impact balance with increased tendency to falls. This may intensify with cognitive impairments (CI), and impede functional recovery. Therefore, task-specific balance training (TSBT), which presents versatile task-specific training options that matches varied individual needs, was explored as a beneficial rehabilitation regime for stroke survivors with and without CI. It was hypothesized that there will be no significant difference in the balance control measures in stroke survivors with and without CI after a 12-month TSBT...
May 2, 2018: Topics in Stroke Rehabilitation
https://www.readbyqxmd.com/read/29702069/gait-and-balance-measures-can-identify-change-from-a-cerebrospinal-fluid-tap-test-in-idiopathic-normal-pressure-hydrocephalus
#14
Ryan Gallagher, Jodie Marquez, Peter Osmotherly
OBJECTIVES: To identify in patients with Idiopathic Normal Pressure Hydrocephalus (iNPH) undergoing a Cerebrospinal Fluid (CSF) Tap Test (TT) for consideration of a Ventricular peritoneal shunt: 1. Gait and balance measures which identify symptom change 2. Differences present between pre and post CSF TT scores between patient's classified responders and non-responders 3. Ability of patients with iNPH to accurately quantify change in their gait and balance symptoms from a CSF TT. DESIGN: Prospective observational study...
April 24, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29689423/evaluating-the-effectiveness-of-behavior-based-safety-education-methods-for-commercial-vehicle-drivers
#15
Xuesong Wang, Yilun Xing, Lian Luo, Rongjie Yu
Risky driving behavior is one of the main causes of commercial vehicle related crashes. In order to achieve safer vehicle operation, safety education for drivers is often provided. However, the education programs vary in quality and may not always be successful in reducing crash rates. Behavior-Based Safety (BBS) education is a popular approach found effective by numerous studies, but even this approach varies as to the combination of frequency, mode and content used by different education providers. This study therefore evaluates and compares the effectiveness of BBS education methods...
April 21, 2018: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29677663/haptic-based-perception-empathy-biofeedback-system-for-balance-rehabilitation-in-patients-with-chronic-stroke-concepts-and-initial-feasibility-study
#16
Kazuhiro Yasuda, Kenta Saichi, Naomi Kaibuki, Hiroaki Harashima, Hiroyasu Iwata
BACKGROUND: Most individuals have sensory disturbances post stroke, and these deficits contribute to post-stroke balance impairment. The haptic-based biofeedback (BF) system appears to be one of the promising tools for balance rehabilitation in patients with stroke, and the BF system can increase the objectivity of feedback and encouragement than that provided by a therapist. RESEARCH QUESTION: Studies in skill science indicated that feedback or encouragement from a coach or trainer enhances motor learning effect...
April 14, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29675114/a-comparative-study-of-conventional-physiotherapy-versus-robot-assisted-gait-training-associated-to-physiotherapy-in-individuals-with-ataxia-after-stroke
#17
Marcia Belas Dos Santos, Clarissa Barros de Oliveira, Arly Dos Santos, Cristhiane Garabello Pires, Viviana Dylewski, Ricardo Mario Arida
Objectives: To assess the influence of RAGT on balance, coordination, and functional independence in activities of daily living of chronic stroke survivors with ataxia at least one year of injury. Methods: It was a randomized controlled trial. The patients were allocated to either therapist-assisted gait training (TAGT) or robotic-assisted gait training (RAGT). Both groups received 3 weekly sessions of physiotherapy with an estimated duration of 60 minutes each and prescribed home exercises...
2018: Behavioural Neurology
https://www.readbyqxmd.com/read/29674285/evaluation-of-muscle-strength-balance-and-functionality-of-individuals-with-type-2-charcot-marie-tooth-disease
#18
Iandra Maria Pinheiro de França Costa, Paula Santos Nunes, Eduardo Luis de Aquino Neves, Lidiane Carine Lima Santos Barreto, Catarina Andrade Garcez, Cynthia Coelho Souza, Paulo Márcio Pereira Oliveira, Luiz Augusto Sales Ferreira, Viviane Nascimento Brandão Lima, Adriano Antunes de Souza Araújo
BACKGROUND: Charcot-Marie-Tooth (CMT) disease is part of a group of genetically determined neuropathies. The intrinsic muscles of the feet and legs are affected early in the disease, impacting balance and mobility. RESEARCH QUESTION: The purpose of this study was to evaluate individuals with type 2 Charcot-Marie-Tooth disease to understand how motor changes interfere in balance and function. METHODS: The sample comprised 15 individuals with CMT2 from the same family (CMT2G) and a control group (CG) of healthy individuals matched for age and gender...
April 5, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29666954/clinical-characteristics-of-a-japanese-patient-with-bardet-biedl-syndrome-caused-by-bbs10-mutations
#19
Kentaro Kurata, Katsuhiro Hosono, Akiko Hikoya, Akihiko Kato, Hirotomo Saitsu, Shinsei Minoshima, Tsutomu Ogata, Yoshihiro Hotta
PURPOSE: Bardet-Biedl syndrome (BBS) is a rare autosomal recessive disorder characterized by retinal dystrophy, renal dysfunction, central obesity, mental impairment, polydactyly, and hypogonadism. Only limited information on BBS is available from Japanese patients. In addition, there are currently no reports of Japanese patients with BBS caused by BBS10 mutations. The purpose of this study was to present the characteristics of a Japanese patient with BBS caused by BBS10 mutations. PATIENT AND METHODS: The patient was a 22-year-old Japanese woman...
April 17, 2018: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29664030/do-practice-gaps-exist-in-evidence-based-medication-prescription-at-hospital-discharge-in-patients-undergoing-coronary-artery-bypass-surgery-coronary-angioplasty
#20
Pradeep Pereira, Aditya Kapoor, Archana Sinha, Surendra K Agarwal, Shantanu Pande, Roopali Khanna, Nilesh Srivastava, Sudeep Kumar, Naveen Garg, Satyendra Tewari, Pravin Goel
Background & objectives: Prescription patterns of guideline-directed medical therapy (GDMT) after coronary artery bypass surgery [coronary artery bypass graft (CABG)] and percutaneous coronary intervention (PCI) at hospital discharge are often not optimal. In view of scarce data from the developing world, a retrospective analysis of medication advice to patients following CABG and PCI was conducted. Methods: Records of 5948 patients (post-PCI: 5152, post-CABG: 796) who underwent revascularization from 2010 to 2014 at a single tertiary care centre in north India were analyzed...
December 2017: Indian Journal of Medical Research
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