keyword
MENU ▼
Read by QxMD icon Read
search

LATCH

keyword
https://www.readbyqxmd.com/read/28817934/mannose-surfaces-exhibit-self-latching-water-structuring-and-resilience-to-chaotropes-implications-for-pathogen-virulence
#1
Hashanthi K Abeyratne-Perera, Preethi L Chandran
Several viral and fungal pathogens, including HIV, SARS, Dengue, Ebola and Cryptococcus neoformans, display a preponderance of mannose residues on their surface, particularly during the infection cycle or in harsh environments. The innate immune system, on the other hand, abounds in mannose receptors which recognize mannose residues on pathogens and trigger their phagocytosis. We pose the question if there is a surface advantage for pathogens to display mannose on their surface, despite these residues being recognized by the immune system...
August 17, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28800437/beyond-the-latch-a-new-approach-to-breastfeeding
#2
Betty Ann Robinson, Gweneth Hartrick Doane
Health professionals supporting breastfeeding play an important role in women successfully achieving their breastfeeding goals. Instrumental knowledge has dominated health professionals' breastfeeding education and practice. Because breastfeeding is a contextual and embodied experience, a relational orientation is required to identify effective strategies to support women. A relational inquiry approach to breastfeeding practice offers a practical way to support women to better achieve their breastfeeding goals within the complexities of their own lives...
August 1, 2017: Nurse Education in Practice
https://www.readbyqxmd.com/read/28766913/feasibility-and-acceptability-of-a-text-message-intervention-used-as-an-adjunct-tool-by-wic-breastfeeding-peer-counsellors-the-latch-pilot
#3
Nurit Harari, Marjorie S Rosenthal, Valerie Bozzi, Lori Goeschel, Teshika Jayewickreme, Chukwuma Onyebeke, Michele Griswold, Rafael Perez-Escamilla
Breastfeeding rates among mothers in the Supplemental Nutrition Program for Women, Infants, and Children (WIC) are lower than for other mothers in the United States. The objective of this study was to test the acceptability and feasibility of the Lactation Advice thru Texting Can Help intervention. Mothers were enrolled at 18-30 weeks gestation from two WIC breastfeeding peer counselling (PC) programmes if they intended to breastfeed and had unlimited text messaging, more than fifth-grade literacy level, and fluency in English or Spanish...
August 1, 2017: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/28760928/parkin-promotes-proteasomal-degradation-of-misregulated-bax
#4
Zeynep Cakir, Kathrin Funk, Joachim Lauterwasser, Franziska Todt, Ralf M Zerbes, Aline Oelgeklaus, Atsushi Tanaka, Martin van der Laan, Frank Edlich
The pro-apoptotic BCL-2 protein BAX commits human cells to apoptosis by permeabilizing the outer mitochondrial membrane. BAX activation has been suggested to require the separation of helix α5 from α6 and thus the 'latch' from the 'core' domain among other conformational changes. Here we show that conformational changes in this region impair BAX translocation to the mitochondria and retrotranslocation back into the cytosol and therefore BAX inhibition, but not activation. Redirecting misregulated BAX to the mitochondria revealed an alternative mechanism of BAX inhibition...
July 31, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28719783/making-sense-of-studies-that-claim-benefits-of-frenotomy-in-the-absence-of-classic-tongue-tie
#5
Pamela Douglas
By performing an in-depth analysis of one high profile example, this article aims to help breastfeeding support professionals understand the methodological flaws that characterize recent studies claiming to show the efficacy of frenotomy for the diagnoses of posterior tongue-tie and upper lip-tie. The example study does not address definitional confusion or control for the effects of the passage of time. It does not consider the effects of caring attention, validation, and lactation consultant support. It also does not consider the extensive research over the past three decades that has established that reflux in the first 6 months of life is benign, even though increased reflux frequency may correlate with unsettled infant behavior...
August 2017: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
https://www.readbyqxmd.com/read/28710905/administration-of-fortifier-by-finger-feeder-during-breastfeeding-in-preterm-infants
#6
Margarita Thanhaeuser, Alexandra Kreissl, Claudia Lindtner, Sophia Brandstetter, Angelika Berger, Nadja Haiden
OBJECTIVE: To evaluate the acceptance, adherence, and feasibility of fortifier administration by finger feeder during breastfeeding and to determine weight, length, and head circumference gains after discharge for preterm infants. DESIGN: Observational pilot study. SETTING: A Level III NICU and its outpatient clinic in Vienna, Austria. PARTICIPANTS: Infants born at younger than 34 weeks gestation were included. METHODS: Mothers were screened in a tertiary NICU and trained by certified lactation consultants to administer fortifier with a finger feeder during breastfeeding...
July 12, 2017: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
https://www.readbyqxmd.com/read/28700719/stair-negotiation-made-easier-using-novel-interactive-energy-recycling-assistive-stairs
#7
Yun Seong Song, Sehoon Ha, Hsiang Hsu, Lena H Ting, C Karen Liu
Here we show that novel, energy-recycling stairs reduce the amount of work required for humans to both ascend and descend stairs. Our low-power, interactive, and modular steps can be placed on existing staircases, storing energy during stair descent and returning that energy to the user during stair ascent. Energy is recycled through event-triggered latching and unlatching of passive springs without the use of powered actuators. When ascending the energy-recycling stairs, naive users generated 17.4 ± 6.9% less positive work with their leading legs compared to conventional stairs, with the knee joint positive work reduced by 37...
2017: PloS One
https://www.readbyqxmd.com/read/28686755/what-s-eating-you-chiggers
#8
Megan E Hohenberger, Dirk M Elston
Belonging to the Trombiculidae family of mites, chigger specifically refers to the larval stage of the mite's life cycle when it is able to bite its host. Although humans act as an accidental host, chiggers will latch on to the skin and their feeding process leads to localized inflammation and irritation. In most cases, these pruritic erythematous papules and papulovesicles are self-healing within a couple weeks, so only symptomatic relief is required as necessary by means of topical antipruritics, oral antihistamines, topical corticosteroids, or an intralesional triamcinolone acetonide injection in severe instances...
June 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/28680082/visualizing-temperature-mediated-activation-of-gelsolin-and-its-deactivation-by-pip2-a-saxs-based-study
#9
Maulik D Badmalia, Shikha Singh, Renu Garg, Ashish
This is the first report describing temperature based initiation of gelsolin's F-actin depolymerization activity, even in absence of free Ca(2+) or low pH. Small angle X-ray scattering (SAXS) and circular dichroism (CD) studies revealed that temperature in the range of 30-40 °C is capable of opening the G1 domain alone, as remaining domains are held together by the Ca(2+)-sensitive C-tail latch without any loss in the secondary structural content. Full opening of all domains of tail-less gelsolin, and retention of closed shape for G2-G6 gelsolin merely by heating, further substantiated our findings...
July 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28665944/molecular-mechanics-of-staphylococcus-aureus-adhesin-cna-and-the-inhibition-of-bacterial-adhesion-by-stretching-collagen
#10
Ali Madani, Kiavash Garakani, Mohammad R K Mofrad
Bacterial adhesion to collagen, the most abundant protein in humans, is a critical step in the initiation and persistence of numerous bacterial infections. In this study, we explore the collagen binding mechanism of the multi-modular cell wall anchored collagen adhesin (CNA) in Staphylococcus aureus and examine how applied mechanical forces can modulate adhesion ability. The common structural-functional elements and domain organization of CNA are present across over 50 genera of bacteria. Through the use of molecular dynamics models and normal mode analysis, we shed light on the CNA's structural and conformational dynamics and its interactions with collagen that lead to collagen binding...
2017: PloS One
https://www.readbyqxmd.com/read/28661702/maternal-gaze-behaviors-during-latching-on-for-breastfeeding
#11
Keiko Kikuchi, Mari Toyota, Keiko Endo, Yasuka Nakamura, Fumi Atogami, Toyoko Yoshizawa
BACKGROUND: Studies in various fields have demonstrated that experts use specific gaze strategies to achieve better performance. Therefore, we hypothesized that mothers familiar with breastfeeding would use a specific gaze strategy to achieve better latching-on. METHODS: A head-mounted eye tracker was used to record pupil positions from 14 breastfeeding mothers with 1-month-old infants. Eye gazes were analyzed during the latching-on and assessment phases. RESULTS: During the latching-on phase, participants tended to fixate on their breast, the infant's lower face, an intermediate region between the infant's face and the breast, and the region of contact between the infant's mouth and the breast...
July 2017: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/28649988/iron-mediated-soil-carbon-response-to-water-table-decline-in-an-alpine-wetland
#12
Yiyun Wang, Hao Wang, Jin-Sheng He, Xiaojuan Feng
The tremendous reservoir of soil organic carbon (SOC) in wetlands is being threatened by water-table decline (WTD) globally. However, the SOC response to WTD remains highly uncertain. Here we examine the under-investigated role of iron (Fe) in mediating soil enzyme activity and lignin stabilization in a mesocosm WTD experiment in an alpine wetland. In contrast to the classic 'enzyme latch' theory, phenol oxidative activity is mainly controlled by ferrous iron [Fe(II)] and declines with WTD, leading to an accumulation of dissolvable aromatics and a reduced activity of hydrolytic enzyme...
June 26, 2017: Nature Communications
https://www.readbyqxmd.com/read/28623094/structural-and-functional-relationships-of-fan1
#13
REVIEW
Hyeonseok Jin, Yunje Cho
FANCD2/FANCI-associated nuclease (FAN1) is a 5' flap structure-specific endonuclease and 5' to 3' exonuclease. This nuclease can resolve interstrand cross-links (ICLs) independently of the Fanconi anemia (FA) pathway and controls the progression of stalled replication forks in an FA-dependent manner, thereby maintaining chromosomal stability. Several FAN1 mutations are observed in various cancers and degenerative diseases. Recently, several crystal structures of the FAN1-DNA complexes have been reported, and to date, these represent the only structures for a DNA bound ICL-repair nuclease...
June 9, 2017: DNA Repair
https://www.readbyqxmd.com/read/28614671/gestalt-breastfeeding-helping-mothers-and-infants-optimize-positional-stability-and-intraoral-breast-tissue-volume-for-effective-pain-free-milk-transfer
#14
Pamela Douglas, Renee Keogh
In the past decade, biological nurturing and activation of maternal and infant instincts after birth have constituted a major advance in clinical breastfeeding support. Yet, physiologic breastfeeding initiation is not enough to ensure ongoing pain-free and effective breastfeeding for many pairs. Current interventions, including "hands-off" mammalian approaches, do not improve breastfeeding outcomes, including in randomized controlled trials. Back-arching, difficulty latching or staying on the breast, and fussing at the breast are common signs of infant positional instability during breastfeeding...
August 2017: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
https://www.readbyqxmd.com/read/28609176/mothers-of-infants-with-congenital-diaphragmatic-hernia-describe-breastfeeding-in-the-neonatal-intensive-care-unit-as-long-as-it-s-my-milk-i-m-happy
#15
Elizabeth B Froh, Janet A Deatrick, Martha A Q Curley, Diane L Spatz
BACKGROUND: Very little is known about the breastfeeding experience of mothers of infants born with congenital anomalies and cared for in the neonatal intensive care unit (NICU). Often, studies related to breastfeeding and lactation in the NICU setting are focused on the mothers of late preterm, preterm, low-birth-weight, and very-low-birth-weight infants. Congenital diaphragmatic hernia (CDH) is an anatomic malformation of the diaphragm and affects 1 in every 2,000 to 4,000 live births...
August 2017: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
https://www.readbyqxmd.com/read/28582997/breastfeeding-and-swallowing-in-a-neonate-with-mild-hypoxic-ischaemic-encephalopathy
#16
Esedra Krüger, Alta Kritzinger, Lidia Pottas
BACKGROUND: Specific breastfeeding and swallowing characteristics in neonates with hypoxic-ischaemic encephalopathy (HIE) have not yet been well described in the literature. Considering the relatively high incidence of HIE in resource-poor settings, speech-language therapists should be cognisant of the feeding difficulties in this population during breastfeeding. OBJECTIVE: To systematically describe the breastfeeding and swallowing of a single case of a neonate diagnosed with mild HIE from admission to discharge...
May 22, 2017: South African Journal of Communication Disorders. die Suid-Afrikaanse Tydskrif Vir Kommunikasieafwykings
https://www.readbyqxmd.com/read/28559306/a-helicase-independent-activity-of-eif4a-in-promoting-mrna-recruitment-to-the-human-ribosome
#17
Masaaki Sokabe, Christopher S Fraser
In the scanning model of translation initiation, the decoding site and latch of the 40S subunit must open to allow the recruitment and migration of messenger RNA (mRNA); however, the precise molecular details for how initiation factors regulate mRNA accommodation into the decoding site have not yet been elucidated. Eukaryotic initiation factor (eIF) 3j is a subunit of eIF3 that binds to the mRNA entry channel and A-site of the 40S subunit. Previous studies have shown that a reduced affinity of eIF3j for the 43S preinitiation complex (PIC) occurs on eIF4F-dependent mRNA recruitment...
June 13, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28538735/ensemble-cryo-em-elucidates-the-mechanism-of-translation-fidelity
#18
Anna B Loveland, Gabriel Demo, Nikolaus Grigorieff, Andrei A Korostelev
Gene translation depends on accurate decoding of mRNA, the structural mechanism of which remains poorly understood. Ribosomes decode mRNA codons by selecting cognate aminoacyl-tRNAs delivered by elongation factor Tu (EF-Tu). Here we present high-resolution structural ensembles of ribosomes with cognate or near-cognate aminoacyl-tRNAs delivered by EF-Tu. Both cognate and near-cognate tRNA anticodons explore the aminoacyl-tRNA-binding site (A site) of an open 30S subunit, while inactive EF-Tu is separated from the 50S subunit...
May 24, 2017: Nature
https://www.readbyqxmd.com/read/28515296/hepatitis-c-virus-lipoviroparticles-assemble-in-the-endoplasmic-reticulum-er-and-bud-off-from-the-er-to-the-golgi-compartment-in-copii-vesicles
#19
Gulam H Syed, Mohsin Khan, Song Yang, Aleem Siddiqui
Hepatitis C virus (HCV) exists as a lipoprotein-virus hybrid lipoviroparticle (LVP). In vitro studies have demonstrated the importance of apolipoproteins in HCV secretion and infectivity, leading to the notion that HCV coopts the secretion of very-low-density lipoprotein (VLDL) for its egress. However, the mechanisms involved in virus particle assembly and egress are still elusive. The biogenesis of VLDL particles occurs in the endoplasmic reticulum (ER), followed by subsequent lipidation in the ER and Golgi compartment...
August 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28502770/an-atomic-structure-of-the-human-spliceosome
#20
Xiaofeng Zhang, Chuangye Yan, Jing Hang, Lorenzo I Finci, Jianlin Lei, Yigong Shi
Mechanistic understanding of pre-mRNA splicing requires detailed structural information on various states of the spliceosome. Here we report the cryo electron microscopy (cryo-EM) structure of the human spliceosome just before exon ligation (the C(∗) complex) at an average resolution of 3.76 Å. The splicing factor Prp17 stabilizes the active site conformation. The step II factor Slu7 adopts an extended conformation, binds Prp8 and Cwc22, and is poised for selection of the 3'-splice site. Remarkably, the intron lariat traverses through a positively charged central channel of RBM22; this unusual organization suggests mechanisms of intron recruitment, confinement, and release...
May 18, 2017: Cell
keyword
keyword
58542
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"