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https://www.readbyqxmd.com/read/29211464/the-case-against-charge-transfer-interactions-in-dissolved-organic-matter-photophysics
#1
Garrett McKay, Julie Ann Korak, Paul R Erickson, Douglas E Latch, Kristopher McNeill, Fernando L Rosario-Ortiz
The optical properties of dissolved organic matter influence chemical and biological processes in all aquatic ecosystems. Organic matter optical properties have been attributed to a charge-transfer model in which donor-acceptor complexes play a primary role. This model was evaluated by measuring the absorbance and fluorescence response of organic matter isolates to perturbations in solvent temperature, viscosity, and polarity, which affect the position and intensity of spectra for known donor-acceptor complexes of organic molecules...
December 6, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29208742/force-induced-strengthening-of-the-interaction-between-staphylococcus-aureus-clumping-factor-b-and-loricrin
#2
Pauline Vitry, Claire Valotteau, Cécile Feuillie, Simon Bernard, David Alsteens, Joan A Geoghegan, Yves F Dufrêne
Bacterial pathogens that colonize host surfaces are subjected to physical stresses such as fluid flow and cell surface contacts. How bacteria respond to such mechanical cues is an important yet poorly understood issue. Staphylococcus aureus uses a repertoire of surface proteins to resist shear stress during the colonization of host tissues, but whether their adhesive functions can be modulated by physical forces is not known. Here, we show that the interaction of S. aureus clumping factor B (ClfB) with the squamous epithelial cell envelope protein loricrin is enhanced by mechanical force...
December 5, 2017: MBio
https://www.readbyqxmd.com/read/29197786/reliability-and-validity-of-the-bristol-breastfeeding-assessment-tool-in-the-turkish-population
#3
Gülümser Dolgun, Sevil İnal, Leyla Erdim, Sevda Korkut
BACKGROUND: breast milk is a natural source of nourishment, with a high level of bioefficacy that is easily digestible, easy to deliver, providing all the fluids, energy and nutrients that are needed for the optimum growth and development of a newborn. OBJECTIVE: this research aims to conduct a reliability and validity study of the Bristol Breastfeeding Assessment Tool (BBAT) in the Turkish population. DESIGN: the research was conducted in methodological design...
November 21, 2017: Midwifery
https://www.readbyqxmd.com/read/29184583/a-qualitative-study-on-negative-emotions-triggered-by-breastfeeding-describing-the-phenomenon-of-breastfeeding-nursing-aversion-and-agitation-in-breastfeeding-mothers
#4
Zainab M Yate
Background: Breastfeeding aversion and agitation (BAA) while breastfeeding is anecdotally known to occur in some women who breastfeed while pregnant or those who tandem feed a newborn and a toddler. However, it is a little-researched area and the paucity of published literature around BAA reveals a significant gap in the literature. Materials and Methods: This study presents the findings and responses of 694 women who filled in an anonymous survey questionnaire that collected data on their basic demographics and their experiences with breastfeeding...
November 2017: Iranian Journal of Nursing and Midwifery Research
https://www.readbyqxmd.com/read/29176554/membrane-insertion-of-the-bax-core-but-not-latch-domain-drives-apoptotic-pore-formation
#5
Hector Flores-Romero, Miguel Garcia-Porras, Gorka Basañez
Despite intensive research effort, how the paradigmatic proapoptotic protein BAX forms lethal apoptotic pores at the mitochondrial outer membrane (MOM) remains incompletely understood. Here, we used biophysical tools and minimalist model systems to identify the specific regions in BAX driving apoptotic pore formation, and to gain more insight into underlying mechanisms. Fluorescence mapping revealed that fully active BAX adopts a BH3-in-groove dimeric conformation in MOM-like membranes, with BAX α4-α5 helices belonging to its core domain inserting deeper into the membrane lipid bilayer than BAX α6-α8 helices belonging to its latch domain...
November 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29166569/breastfeeding-among-women-with-physical-disabilities-in-the-united-states
#6
Robyn M Powell, Monika Mitra, Suzanne C Smeltzer, Linda M Long-Bellil, Lauren D Smith, Eliana Rosenthal, Lisa I Iezzoni
BACKGROUND: The benefits of breastfeeding are well established, and breastfeeding is now widely practiced in the United States. Although increasing numbers of women with physical disabilities are having children, little information is available about breastfeeding practices among these women. Nonetheless, the children of women with physical disabilities should benefit from breastfeeding just as children of nondisabled mothers do. Research aim: This study aimed to explore the facilitators and barriers to breastfeeding among women with physical disabilities...
November 1, 2017: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
https://www.readbyqxmd.com/read/29133662/a-tiny-tick-can-cause-a-big-health-problem
#7
Manuel John, M Raman, Keith Ryan
Ticks are tiny crawling bugs in the spider family that feed by sucking blood from animals. They are second only to mosquitoes as vectors of human disease, both infectious and toxic. Infected ticks spread over a hundred diseases, some of which are fatal if undetected. They spread the spirochete (which multiplies in the insect's gut) with a subsequent bite to the next host. We describe the only reported cases of peri ocular tick bite from India that presented to us within a span of 3 days and its management. Due suspicion and magnification of the lesions revealed the ticks which otherwise masqueraded as small skin tags/moles on gross examination...
November 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29132414/effect-of-frenotomy-on-breastfeeding-variables-in-infants-with-ankyloglossia-tongue-tie-a-prospective-before-and-after-cohort-study
#8
Kathryn Muldoon, Louise Gallagher, Denise McGuinness, Valerie Smith
BACKGROUND: Controversy exists regarding ankyloglossia (tongue-tie) and its clinical impact on breastfeeding, including the benefits, or otherwise, of tongue-tie release (frenotomy). As exclusive breastfeeding rates in Ireland are already considerably low (46% on discharge home from the maternity unit following birth in 2014), it is imperative to protect and support breastfeeding, including identifying the associated effects that frenotomy might have on breastfeeding variables. OBJECTIVE: To determine the associated effects of frenotomy on breastfeeding variables in infants with ankyloglossia...
November 13, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29120371/new-smapf-mesogens-designed-for-analog-electrooptics-applications
#9
Eva D Korblova, Edward Guzman, Joseph E Maclennan, Matthew A Glaser, Renfan Shao, Edgardo Garcia, Yongqiang Shen, Rayshan Visvanathan, Noel A Clark, David M Walba
We have previously reported the first realization of an orthogonal ferroelectric bent-core SmAPF phase by directed design in mesogens with a single tricarbosilane-terminated alkoxy tail. Given the potentially useful electrooptic properties of this phase, including analog phase-only electrooptic index modulation with optical latching, we have been exploring its "structure space", searching for novel SmAPF mesogens. Here, we report two classes of these-the first designed to optimize the dynamic range of the index modulation in parallel-aligned cells by lowering the bend angle of the rigid core, and the second expanding the structure space of the phase by replacing the tricarbosilane-terminated alkyl tail with a polyfluorinated polyethylene glycol oligomer...
November 9, 2017: Materials
https://www.readbyqxmd.com/read/29106586/immunization-with-a-latch-peptide-provides-serotype-independent-protection-against-group-b-streptococcus-infection-in-mice
#10
Shun-Mei Lin, A-Yeung Jang, Yong Zhi, Shuang Gao, Sangyong Lim, Jae Hyang Lim, Joon Young Song, Paul M Sullam, Joon Heang Rhee, Ho Seong Seo
Streptococcus agalactiae (Group B streptococcus, GBS) is a leading cause of neonatal invasive diseases as well as of severe infections in the elderly. The GBS serine rich repeat glycoprotein, Srr1, acts as a critical virulent factor by facilitating GBS invasion into the central nervous system through interaction with the fibrinogen A chain. In this study, we found that Srr1 is highly conserved in GBS clinical isolates (86.7%). Following immunization with different Srr1 truncated peptides, we demonstrated that only mice immunized with Srr1 truncates containing the latch domain were protected against GBS meningitis...
November 2, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29070857/structure-determination-and-activity-manipulation-of-the-turfgrass-aba-receptor-fepyr1
#11
Zhizhong Ren, Zhen Wang, X Edward Zhou, Huazhong Shi, Yechun Hong, Minjie Cao, Zhulong Chan, Xue Liu, H Eric Xu, Jian-Kang Zhu
Turfgrass are widely cultivated ornamental plants that have important ecological, societal and economical values. However, many turfgrass species are susceptible to drought and demand frequent irrigation thus consuming large amounts of water. With the ultimate goal of improving drought resistance in turfgrass, we identified several ABA receptors in turfgrass that are important to mediate ABA signaling and drought stress response. The ABA receptor FePYR1 from turfgrass Festuca elata was demonstrated to bind ABA as a monomer...
October 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29030428/a-retractable-lid-in-lecithin-cholesterol-acyltransferase-provides-a-structural-mechanism-for-activation-by-apolipoprotein-a-i
#12
Kelly A Manthei, Joomi Ahn, Alisa Glukhova, Wenmin Yuan, Christopher Larkin, Taylor D Manett, Louise Chang, James A Shayman, Milton J Axley, Anna Schwendeman, John J G Tesmer
Lecithin:cholesterol acyltransferase (LCAT) plays a key role in reverse cholesterol transport by transferring an acyl group from phosphatidylcholine to cholesterol, promoting the maturation of high density lipoproteins (HDL) from discoidal to spherical particles. LCAT is activated through an unknown mechanism by apolipoprotein A-I (ApoA-I) and other mimetic peptides that form a belt around HDL. Here we report the crystal structure of LCAT with an extended lid that blocks access to the active site, consistent with an inactive conformation...
October 13, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28978404/switching-on-btk-one-domain-at-a-time
#13
Christopher Agnew, Natalia Jura
BTK kinase activity is controlled by multiple inhibitory domains, whose coordinated mechanism of action is poorly understood. In this issue of Structure,Joseph et al. (2017) use solution-based approaches to characterize conformational changes associated with the binding of each inhibitory tether, revealing a multi-step activation process and a previously unknown C-terminal autoinhibitory latch.
October 3, 2017: Structure
https://www.readbyqxmd.com/read/28945411/ultrastable-artificial-binding-pairs-as-a-supramolecular-latching-system-a-next-generation-chemical-tool-for-proteomics
#14
Kyeng Min Park, James Murray, Kimoon Kim
In this Commentary, we discuss cucurbit[7]uril-based ultrastable artificial binding pairs as a supramolecular latching system and how we envision this becoming important tools in proteomics. The limitations of current proteomic techniques are described with an emphasis on the lack of tools to answer questions about the complex and dynamic nature of the proteome. Our thoughts as to how artificial ultrastable binding pairs may be able to address these questions are given especially when they are combined with existing methods...
March 21, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28930483/breastfeeding-characteristics-of-late-preterm-infants-in-a-kangaroo-mother-care-unit
#15
Melissa Pike, Alta Kritzinger, Esedra Krüger
OBJECTIVE: To describe the breastfeeding characteristics of late-preterm infants (LPIs) in a kangaroo mother care (KMC) unit. MATERIALS AND METHODS: In a 20-bed KMC unit, the breastfeeding of 73 purposively-selected LPIs' (mean gestational age: 34.8 weeks) was observed once-off, using the Preterm Infant Breastfeeding Behavior Scale. Participants' mean age was 9.5 days, mean number of days in the unit was 3.1 days, and mean number of days breastfeeding was 7.5 on observation...
September 20, 2017: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/28879823/first-time-mothers-breast-feeding-maintenance-role-of-experiences-and-changes-in-maternal-perceptions
#16
Ellen J Schafer, Shelly Campo, Tarah T Colaizy, Pamela J Mulder, Patrick Breheny, Sato Ashida
OBJECTIVE: Breast-feeding initiation rates have increased in the USA; however, maintenance of breast-feeding for recommended durations is low. The objective of the present study was to identify factors that may facilitate breast-feeding for longer durations among first-time mothers, including physiological and social experiences and changes in maternal perceptions. DESIGN: Survival analysis and linear regression methods were used to explore the relationship between experiences and breast-feeding duration, and the possible mediating effect of changes in maternal perceptions...
September 7, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28878793/activation-of-aba-receptors-gene-ghpyl9-11a-is-positively-correlated-with-cotton-drought-tolerance-in-transgenic-arabidopsis
#17
Chengzhen Liang, Yan Liu, Yanyan Li, Zhigang Meng, Rong Yan, Tao Zhu, Yuan Wang, Shujing Kang, Muhammad Ali Abid, Waqas Malik, Guoqing Sun, Sandui Guo, Rui Zhang
The sensitivity to abscisic acid (ABA) by its receptors, pyrabactin resistance-like proteins (PYLs), is considered a most important factor in activating the ABA signal pathway in response to abiotic stress. However, it is still unknown which PYL is the crucial ABA receptor mediating response to drought stress in cotton (Gossypium hirsutum L.). Here, we reported the identification and characterization of highly induced ABA receptor GhPYL9-11A in response to drought in cotton. It is observed that GhPYL9-11A was highly induced by ABA treatment...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28874469/fibrinogen-activates-the-capture-of-human-plasminogen-by-staphylococcal-fibronectin-binding-proteins
#18
Philippe Herman-Bausier, Giampiero Pietrocola, Timothy J Foster, Pietro Speziale, Yves F Dufrêne
Invasive bacterial pathogens can capture host plasminogen (Plg) and allow it to form plasmin. This process is of medical importance as surface-bound plasmin promotes bacterial spread by cleaving tissue components and favors immune evasion by degrading opsonins. In Staphylococcus aureus, Plg binding is in part mediated by cell surface fibronectin-binding proteins (FnBPs), but the underlying molecular mechanism is not known. Here, we use single-cell and single-molecule techniques to demonstrate that FnBPs capture Plg by a sophisticated activation mechanism involving fibrinogen (Fg), another ligand found in the blood...
September 5, 2017: MBio
https://www.readbyqxmd.com/read/28867612/achieving-a-graded-immune-response-btk-adopts-a-range-of-active-inactive-conformations-dictated-by-multiple-interdomain-contacts
#19
Raji E Joseph, Thomas E Wales, D Bruce Fulton, John R Engen, Amy H Andreotti
Capturing the functionally relevant forms of dynamic, multidomain proteins is extremely challenging. Bruton's tyrosine kinase (BTK), a kinase essential for B and mast cell function, has stubbornly resisted crystallization in its full-length form. Here, nuclear magnetic resonance and hydrogen-deuterium exchange mass spectrometry show that BTK adopts a closed conformation in dynamic equilibrium with open, active conformations. BTK lacks the phosphotyrosine regulatory tail of the SRC kinases, yet nevertheless achieves a phosphotyrosine-independent C-terminal latch...
October 3, 2017: Structure
https://www.readbyqxmd.com/read/28855320/performance-morphology-and-control-of-power-amplified-mandibles-in-the-trap-jaw-ant-myrmoteras-hymenoptera-formicidae
#20
Fredrick J Larabee, Wulfila Gronenberg, Andrew V Suarez
Trap-jaw ants are characterized by high-speed mandibles used for prey capture and defense. Power-amplified mandibles have independently evolved at least four times among ants, with each lineage using different structures as a latch, spring and trigger. We examined two species from the genus Myrmoteras (subfamily Formicinae), whose morphology is unique among trap-jaw ant lineages, and describe the performance characteristics, spring-loading mechanism and neuronal control of Myrmoteras strikes. Like other trap-jaw ants, Myrmoteras latch their jaws open while the large closer muscle loads potential energy in a spring...
September 1, 2017: Journal of Experimental Biology
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