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https://www.readbyqxmd.com/read/28918401/return-to-work-and-lost-earnings-after-acute-respiratory-distress-syndrome-a-5-year-prospective-longitudinal-study-of-long-term-survivors
#1
Biren B Kamdar, Kristin A Sepulveda, Alexandra Chong, Robert K Lord, Victor D Dinglas, Pedro A Mendez-Tellez, Carl Shanholtz, Elizabeth Colantuoni, Till M von Wachter, Peter J Pronovost, Dale M Needham
BACKGROUND: Delayed return to work is common after acute respiratory distress syndrome (ARDS), but has undergone little detailed evaluation. We examined factors associated with the timing of return to work after ARDS, along with lost earnings and shifts in healthcare coverage. METHODS: Five-year, multisite prospective, longitudinal cohort study of 138 2-year ARDS survivors hospitalised between 2004 and 2007. Employment and healthcare coverage were collected via structured interview...
September 16, 2017: Thorax
https://www.readbyqxmd.com/read/28906543/the-role-of-atrial-fibrillation-in-patients-with-an-embolic-stroke-of-unknown-source-esus
#2
Rolf Wachter, Ben Freedman
No abstract text is available yet for this article.
September 14, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28904084/relevance-of-supraventricular-runs-detected-after-cerebral-ischemia
#3
Mark Weber-Krüger, Constanze Lutz, Antonia Zapf, Raoul Stahrenberg, Joachim Seegers, Janin Witzenhausen, Katrin Wasser, Gerd Hasenfuß, Klaus Gröschel, Rolf Wachter
OBJECTIVE: Prolonged ECG monitoring after stroke frequently reveals short paroxysmal atrial fibrillation (pAF) and supraventricular (SV) runs. The minimal duration of atrial fibrillation (AF) required to induce cardioembolism, the relevance of SV runs, and whether short pAF results from cerebral damage itself are currently being debated. We aimed to study the relevance of SV runs and short pAF detected by prolonged Holter ECG after cerebral ischemia during long-term follow-up. METHODS: Analysis is from the prospective Find-AF trial (ISRCTN46104198)...
September 13, 2017: Neurology
https://www.readbyqxmd.com/read/28885446/implementing-a-health-system-wide-patient-blood-management-program-with-a-clinical-community-approach
#4
Steven M Frank, Rajiv N Thakkar, Stanley J Podlasek, K H Ken Lee, Tyler L Wintermeyer, Will W Yang, Jing Liu, Leo C Rotello, Thomas A Fleury, Pat A Wachter, Lisa E Ishii, Renee Demski, Peter J Pronovost, Paul M Ness
BACKGROUND: Patient blood management programs are gaining popularity as quality improvement and patient safety initiatives, but methods for implementing such programs across multihospital health systems are not well understood. Having recently incorporated a patient blood management program across our health system using a clinical community approach, we describe our methods and results. METHODS: We formed the Johns Hopkins Health System blood management clinical community to reduce transfusion overuse across five hospitals...
September 7, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28880349/-parental-alienation-and-the-controversy-surrounding-psychiatric-diagnostics
#5
C Migchels, D De Wachter
The phenomenon of parental alienation can arise when a child allies with one parent and refuses to have contact with the other parent. The concept has attracted a great deal of attention over the last few years. There has been controversy about whether parental alienation should be recognised as a psychiatric syndrome of the alienated child caught up in a conflict between supporters and opponents.<br/> AIM: To try to determine whether parental alienation belongs to psychiatric diagnostics.<br/> METHOD: We made a careful study of various databases in order to find literature relating to parental alienation...
2017: Tijdschrift Voor Psychiatrie
https://www.readbyqxmd.com/read/28842973/incidence-of-previously-undiagnosed-atrial-fibrillation-using-insertable-cardiac-monitors-in-a-high-risk-population-the-reveal-af-study
#6
James A Reiffel, Atul Verma, Peter R Kowey, Jonathan L Halperin, Bernard J Gersh, Rolf Wachter, Erika Pouliot, Paul D Ziegler
Importance: In approximately 20% of atrial fibrillation (AF)-related ischemic strokes, stroke is the first clinical manifestation of AF. Strategies are needed to identify and therapeutically address previously undetected AF. Objective: To quantify the incidence of AF in patients at high risk for but without previously known AF using an insertable cardiac monitor. Design, Setting, and Participants: This prospective, single-arm, multicenter study was conducted from November 2012 to January 2017...
August 26, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28830496/what-can-the-cf-registry-tell-us-about-rare-cftr-mutations-a-belgian-study
#7
E De Wachter, M Thomas, S S Wanyama, S Seneca, A Malfroot
BACKGROUND: CFTR2 provides clinical and functional information of the most common CFTR-mutations. Rare mutations (RMs) occur in only a few patients with limited reported clinical data. Their role in CF-disease liability is hardly documented. METHODS: Belgian CF-Registry 2013 data were analyzed to identify CF with at least 1 RM (CF+RM). Clinical data and sweat chloride of CF+RM were compared to CF-controls, carrying 2 class 1 to 3 mutations (CFclassic). Disease severity was compared between both groups...
August 22, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/28814822/high-visibility-in-two-color-above-threshold-photoemission-from-tungsten-nanotips-in-a-coherent-control-scheme
#8
Timo Paschen, Michael Förster, Michael Krüger, Christoph Lemell, Georg Wachter, Florian Libisch, Thomas Madlener, Joachim Burgdörfer, Peter Hommelhoff
In this article, we present coherent control of above-threshold photoemission from a tungsten nanotip achieving nearly perfect modulation. Depending on the pulse delay between fundamental ([Formula: see text]) and second harmonic ([Formula: see text]) pulses of a femtosecond fiber laser at the nanotip, electron emission is significantly enhanced or depressed during temporal overlap. Electron emission is studied as a function of pulse delay, optical near-field intensities, DC bias field and final photoelectron energy...
June 17, 2017: Journal of Modern Optics
https://www.readbyqxmd.com/read/28806832/-dorsal-ligamentoplasty-for-posttraumatic-scapholunate-dissociation
#9
Ralf Bajinski, Joachim Gülke, Martin Mentzel, Florian Sigloch, Moritz Dustmann, Nikolaus Johannes Wachter
Scapholunate dissociation in stages 2 and 3 may lead to posttraumatic damage if left untreated. Different types of treatment have been described, including capsulodesis, tenodesis, and others. The purpose of all procedures is to avoid palmar shift of the distal scaphoid resulting in secondary arthritis (SLAC wrist). This study aimed to evaluate a modified dorsal ligamentoplasty in second- and third-degree scapholunate dissociation in a prospective study design. Furthermore, the study aimed to find out if there is a correlation between radiological and clinical parameters at follow-up and whether or not a SLAC wrist can be avoided...
August 2017: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
https://www.readbyqxmd.com/read/28804596/characterisation-of-tumour-derived-microvesicles-in-cancer-patients-blood-and-correlation-with-clinical-outcome
#10
Kerstin Menck, Annalen Bleckmann, Astrid Wachter, Bianca Hennies, Lena Ries, Matthias Schulz, Marko Balkenhol, Tobias Pukrop, Bawarjan Schatlo, Ulrike Rost, Dirk Wenzel, Florian Klemm, Claudia Binder
To evaluate whether tumour-derived microvesicles (T-MV), originating from the plasma membrane, represent suitable cancer biomarkers, we isolated MV from peripheral blood samples of cancer patients with locally advanced and/or metastatic solid tumours (n = 330, including 79 head & neck cancers, 74 lung cancers, 41 breast cancers, 28 colorectal cancers and 108 with other cancer forms) and controls (n = 103). Whole MV preparations were characterised using flow cytometry. While MV carrying the tumour-associated proteins MUC1, EGFR and EpCAM were found to be enhanced in a tumour-subtype-specific way in patients' blood, expression of the matrix metalloproteinase inducer EMMPRIN was increased independent of tumour type...
2017: Journal of Extracellular Vesicles
https://www.readbyqxmd.com/read/28795566/nucleotide-dependence-of-subunit-rearrangements-in-short-form-rubisco-activase-from-spinach
#11
Dayna S Peterson-Forbrook, Matthew T Hilton, Laura Tichacek, J Nathan Henderson, Hoang Q Bui, Rebekka M Wachter
Higher-plant Rubisco activase (Rca) plays a critical role in regulating the activity of ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco). In vitro, Rca is known to undergo dynamic assembly-disassembly processes, with several oligomer stoichiometries coexisting over a broad concentration range. Although the hexamer appears to be the active form, changes in quaternary structure could play a role in Rubisco regulation. Therefore, fluorescent labels were attached to the C-termini of spinach β-Rca, and the rate of subunit mixing was monitored by measuring energy transfer as a function of nucleotide and divalent cation...
August 25, 2017: Biochemistry
https://www.readbyqxmd.com/read/28782134/gut-microbiomes-of-free-ranging-and-captive-namibian-cheetahs-diversity-putative-functions-and-occurrence-of-potential-pathogens
#12
Wasim Uddin, Sebastian Menke, Jörg Melzheimer, Susanne Thalwitzer, Sonja Heinrich, Bettina Wachter, Simone Sommer
Although the significance of the gut microbiome for host health is well acknowledged, the impact of host traits and environmental factors on the inter-individual variation of gut microbiomes of wildlife species is not well understood. Such information is essential, however, since changes in the composition of these microbial communities beyond the natural range might cause dysbiosis leading to increased susceptibility to infections. We examined the potential influence of sex, age, genetic relatedness, spatial tactics, and the environment on the natural range of the gut microbiome diversity in free-ranging Namibian cheetahs (Acinonyx jubatus)...
August 7, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28772053/heart-failure-awareness-survey-in-germany-general-knowledge-on-heart-failure-remains-poor
#13
Christine Zelenak, Sara Radenovic, Lindy Musial-Bright, Elvis Tahirovic, Mesud Sacirovic, Chong-Bin Lee, Diana Jahandar-Lashki, Simone Inkrot, Tobias Daniel Trippel, Andreas Busjahn, Djawid Hashemi, Rolf Wachter, Sabine Pankuweit, Stefan Störk, Burkert Pieske, Frank Edelmann, Hans-Dirk Düngen
AIMS: Previous studies demonstrated poor public awareness of heart failure (HF) compared with myocardial infarction and stroke. With respect to several activities to improve HF awareness in recent years, we present data on the development of HF awareness and information sources in Germany over 8 years. METHODS AND RESULTS: In 2007, 2012, and 2015, respectively, 2531, 359, and 171 respondents answered questions about causes, presentation, prognosis, and treatment of HF from a survey developed by the German Competence Network HF...
August 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/28771491/atrial-fibrillation-in-retinal-vascular-occlusion-disease-and-non-arteritic-anterior-ischemic-optic-neuropathy
#14
Josep Callizo, Nicolas Feltgen, Antje Ammermann, Janina Ganser, Sebastian Bemme, Thomas Bertelmann, Sebastian Pfeiffer, Andre Duvinage, Klaus Gröschel, Hans Hoerauf, Rolf Wachter
BACKGROUND: Patients with retinal vascular occlusion disease have an increased risk for ischemic stroke and share some risk factors with cerebrovascular disease. The purpose of this study was to analyze the prevalence of atrial fibrillation (AF) in subjects with retinal vascular occlusive disease and anterior ischemic optic neuropathy and to compare these data to an ischemic stroke group. METHODS: Prospective, observational single-center trial. Subjects with retinal artery occlusion (RAO), retinal vein occlusion (RVO) and anterior ischemic optic neuropathy (AION) were included...
2017: PloS One
https://www.readbyqxmd.com/read/28730331/-early-functional-passive-mobilization-of-flexor-tendon-injuries-of-the-hand-zone%C3%A2-2-exercise-with-an-exoskeleton-compared-to-physical-therapy
#15
Joachim Gülke, Martin Mentzel, Gert Krischak, David Gulkin, Daniel Dornacher, Nikolaus Wachter
BACKGROUND: These days there are different types of aftercare following flexor tendon injury. Patients in this study received a dynamic Kleinert protocol and additionally two different postoperative treatments. Both treatment groups were compared to each other and results were put into perspective when compared to other treatment options. METHODS: Sixty-two patients presenting with clean lesions of the two flexor tendons in zone 2 received postoperative treatment with a dynamic Kleinert protocol...
July 20, 2017: Der Unfallchirurg
https://www.readbyqxmd.com/read/28708172/design-rules-for-combined-label-free-and-fluorescence-bloch-surface-wave-biosensors
#16
Francesco Michelotti, Riccardo Rizzo, Alberto Sinibaldi, Peter Munzert, Christoph Wächter, Norbert Danz
We report on the fabrication and physical characterization of optical biosensors implementing simultaneous label-free and fluorescence detection and taking advantage of the excitation of Bloch surface waves at a photonic crystal's truncation interface. Two types of purposely designed one-dimensional photonic crystals on molded organic substrates with micro-optics were fabricated. These crystals feature either high or low finesse of the Bloch surface wave resonances and were tested on the same optical readout system...
July 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28692068/allosteric-sensitization-of-proapoptotic-bax
#17
Jonathan R Pritz, Franziska Wachter, Susan Lee, James Luccarelli, Thomas E Wales, Daniel T Cohen, Paul Coote, Gregory J Heffron, John R Engen, Walter Massefski, Loren D Walensky
BCL-2-associated X protein (BAX) is a critical apoptotic regulator that can be transformed from a cytosolic monomer into a lethal mitochondrial oligomer, yet drug strategies to modulate it are underdeveloped due to longstanding difficulties in conducting screens on this aggregation-prone protein. Here, we overcame prior challenges and performed an NMR-based fragment screen of full-length human BAX. We identified a compound that sensitizes BAX activation by binding to a pocket formed by the junction of the α3-α4 and α5-α6 hairpins...
September 2017: Nature Chemical Biology
https://www.readbyqxmd.com/read/28678646/pain-areas-and-mechanosensitivity-in-patients-with-chronic-pelvic-pain-syndrome-a-controlled-clinical-investigation
#18
Jörgen Quaghebeur, Jean-Jacques Wyndaele, Stefan De Wachter
OBJECTIVE: A thorough clinical assessment including physical examination is crucial in a diagnostic work-up, including in patients with chronic pelvic pain syndrome (CPPS). This study investigated the prevalence of pain areas and the mechanosensitivity of peripheral nerves in patients with CPPS and compared the findings with a healthy control group. MATERIALS AND METHODS: Healthy volunteers and patients diagnosed with CPPS were assessed with physical examinations and neurodynamic testing...
July 5, 2017: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/28668197/improving-healthcare-value-through-clinical-community-and-supply-chain-collaboration
#19
Lisa Ishii, Renee Demski, K H Ken Lee, Zishan Mustafa, Steve Frank, Jean Paul Wolisnky, David Cohen, Jay Khanna, Joshua Ammerman, Harpal S Khanuja, Anthony S Unger, Lois Gould, Patricia Ann Wachter, Lauren Stearns, Ronald Werthman, Peter Pronovost
BACKGROUND: We hypothesized that integrating supply chain with clinical communities would allow for clinician-led supply cost reduction and improved value in an academic health system. METHODS: Three clinical communities (spine, joint, blood management) and one clinical community-like physician led team of surgeon stakeholders partnered with the supply chain team on specific supply cost initiatives. The teams reviewed their specific utilization and cost data, and the physicians led consensus-building conversations over a series of team meetings to agree to standard supply utilization...
March 2017: Healthcare
https://www.readbyqxmd.com/read/28655474/quantification-of-hand-function-by-power-grip-and-pinch-strength-force-measurements-in-ulnar-nerve-lesion-simulated-by-ulnar-nerve-block
#20
Nikolaus Johannes Wachter, Martin Mentzel, Gert D Krischak, Joachim Gülke
INTRODUCTION: In the assessment of hand and upper limb function, grip strength is of the major importance. The measurement by dynamometers has been established. PURPOSE OF THE STUDY: In this study, the effect of a simulated ulnar nerve lesion on different grip force measurements was evaluated. METHODS: In 25 healthy volunteers, grip force measurement was done by the JAMAR dynamometer (Fabrication Enterprises Inc, Irvington, NY) for power grip and by a pinch strength dynamometer for tip pinch strength, tripod grip, and key pinch strength...
June 24, 2017: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
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