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Christian Wächter, Lee E Eiden, Nedye Naumann, Candan Depboylu, Eberhard Weihe
BACKGROUND: The majority of investigations on HIV-associated neurocognitive disorders (HAND) neglect the cerebellum in spite of emerging evidence for its role in higher cognitive functions and dysfunctions in common neurodegenerative diseases. METHODS: We systematically investigated the molecular and cellular responses of the cerebellum as contributors to lentiviral infection-induced neurodegeneration, in the simian immunodeficiency virus (SIV)-infected rhesus macaque model for HIV infection and HAND...
October 14, 2016: Journal of Neuroinflammation
F Wachter, A M Morgan, M Godes, R Mourtada, G H Bird, L D Walensky
Hydrocarbon-stapled peptides that display key residues of the p53 transactivation domain have emerged as bona fide clinical candidates for reactivating the tumor suppression function of p53 in cancer by dual targeting of the negative regulators HDM2 and HDMX. A recent study questioned the mechanistic specificity of such stapled peptides based on interrogating their capacity to disrupt p53/HDM2 and p53/HDMX complexes in living cells using a new recombinase enhanced bimolecular luciferase complementation platform (ReBiL)...
October 10, 2016: Oncogene
Jenny Wachter, Stuart A Hill
As virulence often correlates with the presence of plasmid replicons in several Vibrio spp., this study investigated whether non-chromosomal DNA could be found in the coral pathogen, Vibrio coralliilyticus BAA-450. A circular plasmid, 26,631 bp in size, was identified. DNA sequence analysis indicated that the plasmid contained 30 open reading frames, six tRNA genes, 12 inverted repeats, three direct repeats and presented no continuous sequence identity to other replicons within the database. Consequently, these findings indicate that this is a novel, previously unidentified, plasmid...
January 4, 2016: Microorganisms
Francesco Vitali, Deike Strobel, Lukas Pfeifer, Marc Heinrich, David Wachter, Markus F Neurath, Dane Wildner
No abstract text is available yet for this article.
January 2016: Endoscopy
Noemie Prat, Camille Guilbert, Ursa Prah, Elisabeth Wachter, Barbara Steiner, Thierry Langin, Olivier Robert, Hermann Buerstmayr
The QTL Fhb1 was successfully introgressed and validated in three durum wheat populations. The novel germplasm and the QTL detected will support improvement of Fusarium resistance in durum wheat. Durum wheat (Triticum durum Desf.) is particularly susceptible to Fusarium head blight (FHB) and breeding for resistance is hampered by limited genetic variation within this species. To date, resistant sources are mainly available in a few wild relative tetraploid wheat accessions. In this study, the effect of the well-known hexaploid wheat (Triticum aestivum L...
September 23, 2016: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
Sara Persyn, Jane Eastham, Stefan De Wachter, James Gillespie
A growing body of work is describing the absence of a significant sympathetic innervation of the detrusor implying little sympathetic regulation of bladder contractility. However, low doses of adrenergic agonists are capable of relaxing the bladder smooth muscle. If these effects underpin a physiological response then the cellular nature and operation of this system are currently unknown. The present immunohistochemistry study was done to explore the existence of alternative adrenergic signaling elements in the rat bladder wall...
September 10, 2016: Autonomic Neuroscience: Basic & Clinical
D L Wachter
Breast cancer can be divided into four molecular subtypes with different prognoses using immunohistochemical markers in the routine clinicopathological work-up. The protein Ki-67 is of central importance in this context, in particular to distinguish between luminal A and luminal B carcinomas. Determination of the Ki-67 index of a carcinoma also allows a prediction of the likelihood of the response to chemotherapy. Additionally, the expression of certain cytokeratins in tumor cells is associated with a poor response to chemotherapy...
September 14, 2016: Der Pathologe
Hardy Baumbach, Samir Ahad, Stephan Hill, Tim Schäufele, Sara Adili, Kristina Wachter, Ulrich F W Franke
An increasing number of patients with severe aortic stenosis and concomitant critical coronary artery disease were referred to our hospital. Some of those patients were classified as high-risk patients qualifying for a transcatheter therapy with the additional need for coronary revascularization. As a consequence of their comorbidities, the established transapical as well as transfemoral approach were either not possible or not favored owing to the indispensable need for coronary revascularization. We present 4 successfully combined off-pump procedures consisting of a transcatheter aortic valve implantation (Edwards SAPIEN XT) via the transaortic approach and an off-pump coronary artery bypass grafting...
September 15, 2016: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
Lennart Henning Stieglitz, Karen Wachter, Luca Regli
No abstract text is available yet for this article.
September 2016: Praxis
Thao L Masters, Jenny Wachter, Stuart Hill
Regulation of the Neisseria gonorrhoeae pilE gene is ill-defined. In this study, post-transcriptional effects on expression were assessed. In silico analysis predicts the formation of three putative stable stem-loop structures with favorable free energies within the 5 untranslated region (UTR) of the pilE message. Using quantitative reverse transcriptase PCR (qRT-PCR) analyses, we show that each loop structure forms, with introduced destabilizing stem loop mutations diminishing loop stability. Utilizing a series of pilE translational fusions, deletion of either loop 1 or loop 2 caused a significant reduction of pilE mRNA resulting in reduced expression of the reporter gene...
September 1, 2016: Microbiology
J Gülke, H Schöll, T Kapapa, T Geyer, M Mentzel, N J Wachter
BACKGROUND: Wrist fusion is still a common treatment for patients with advanced stage arthritis. Since patients are often intimidated by the functional limitations, we intended to evaluate the influence of the lack of wrist motion in different positions on the dynamic grip function and the grip strength of the hand. METHODS: We simulated wrist fusion in 20° extension and 20° flexion and evaluated the following grip types: fist closure, 2 different power grips, pinch grip and precision grip...
August 2016: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
J Gülke, M Mentzel, D Dornacher, L Schneider, T Kapapa, N J Wachter
BACKGROUND/PURPOSE: Joint replacement is a widely used procedure to treat painful osteoarthritis of the proximal interphalangeal joint. From 1996 to 1999, 16 patients received 19 hinged, piston-based DIGITOS prostheses in our department. In 2007, the 7-year clinical course of 14 patients (17 devices) was published in this journal. Now 12 of these patients (15 devices) have been followed with an average history of 17 years, and the preoperative data has been compared with the results after 7 and 17 years, respectively...
August 2016: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
Stavros V Konstantinides, Stefano Barco, Stephan Rosenkranz, Mareike Lankeit, Matthias Held, Felix Gerhardt, Leonard Bruch, Ralf Ewert, Martin Faehling, Julia Freise, Hossein-Ardeschir Ghofrani, Ekkehard Grünig, Michael Halank, Nadine Heydenreich, Marius M Hoeper, Hanno H Leuchte, Eckhard Mayer, F Joachim Meyer, Claus Neurohr, Christian Opitz, Antonio Pinto, Hans-Jürgen Seyfarth, Rolf Wachter, Bianca Zäpf, Heinrike Wilkens, Harald Binder, Philipp S Wild
Acute pulmonary embolism (PE) is a frequent cause of death and serious disability. The risk of PE-associated mortality and morbidity extends far beyond the acute phase of the disease. In earlier follow-up studies, as many as 30 % of the patients died during a follow-up period of up to 3 years, and up to 50 % of patients continued to complain of dyspnea and/or poor physical performance 6 months to 3 years after the index event. The most feared 'late sequela' of PE is chronic thromboembolic pulmonary hypertension (CTEPH), the true incidence of which remains obscure due to the large margin of error in the rates reported by mostly small, single-center studies...
November 2016: Journal of Thrombosis and Thrombolysis
J Menne, R Wachter
Invasive treatment methods-more specifically renal denervation and baroreceptor activator therapy-have been used for the treatment of therapy-resistant hypertension for several years now. In particular, renal denervation has aroused great interest because it was easy to perform and the first studies provided very promising results. Meanwhile, however, three randomized, blinded studies have been published, and none showed a significant benefit of renal denervation compared to a sham procedure. In addition, in several studies it was demonstrated that intensification of drug therapy, particularly with spironolactone, is at least comparable...
September 2016: Der Internist
Robert M Wachter
The author, a former chair of the ABIM, describes the challenges that the board certification enterprise is experiencing as medicine shifts from being a paper-based to a digital industry. While there are clearly threats to board certification, he argues that boards can remain highly relevant if they focus on areas in which they can make unique contributions, such as the measurement of cognitive skills, diagnostic accuracy, "keeping up," and procedural skills.
September 2016: Ophthalmology
Jenny Wachter, Stuart Hill
Pathogenic species of Neisseria utilize variable outer membrane proteins to facilitate infection and proliferation within the human host. However, the mechanisms behind the evolution of these variable alleles remain largely unknown due to analysis of previously limited datasets. In this study, we have expanded upon the previous analyses to substantially increase the number of analyzed sequences by including multiple diverse strains, from various geographic locations, to determine whether positive selective pressure is exerted on the evolution of these variable genes...
2016: PloS One
Marco Robin Schroeter, Herdis Köhler, Astrid Wachter, Annalen Bleckmann, Gerd Hasenfuß, Wolfgang Schillinger
AIMS: Impella is a microaxial rotary pump that is placed across the aortic valve to expel aspirated blood from the left ventricle into the ascending aorta; it can be used in cardiogenic shock. While previous studies have evaluated the efficacy and safety of the Impella device, more clinically relevant data are necessary, especially with regard to outcomes. METHODS AND RESULTS: We screened our database of Impella patients in our heart center and found 68 consecutive patients who underwent Impella implantation due to acute coronary syndrome (ACS) complicated by cardiogenic shock...
August 15, 2016: Journal of Invasive Cardiology
Hardy Baumbach, Samir Ahad, Christian Rustenbach, Stephan Hill, Tim Schäufele, Kristina Wachter, Ulrich Friedrich Wilhelm Franke
Background The incidence of degenerative aortic valve diseases has increased along with the life expectancy of our population. Although conventional aortic valve replacement (AVR) is the gold standard for symptomatic aortic stenosis, transcatheter procedures have proven to be a valid therapeutic option in high-risk patients. The aim of this study was to compare these procedures in a high-risk cohort. Methods We retrospectively analyzed all symptomatic (dyspnea or angina) high-risk patients (logistic EuroSCORE ≥ 15%) fulfilling the transcatheter aortic valve implantation (TAVI) indications...
August 12, 2016: Thoracic and Cardiovascular Surgeon
Robert M Wachter, Lee Goldman
Twenty years ago, we described the emergence of a new type of specialist that we called a "hospitalist." Since then, the number of hospitalists has grown from a few hundred to more than 50,000 (see graph) — making this new field substantially larger than any subspecialty of internal medicine (the..
September 15, 2016: New England Journal of Medicine
R Wachter, M Halbach, G Bakris, J Bisognano, H Haller, J Beige, A A Kroon, M Nadim, E Lovett, J Schafer, P W de Leeuw
OBJECTIVE: To compare safety and blood pressure (BP) reductions obtained with first- and second-generation systems for administering baroreflex activation therapy (BAT) in patients with resistant hypertension, as well as to verify that BP reductions with active BAT are distinguishable from placebo and Hawthorne effects observed with sham control. DESIGN AND METHOD: Second-generation data were available from 30 patients implanted in a single-arm verification study...
September 2016: Journal of Hypertension
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