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https://www.readbyqxmd.com/read/29762469/individualised-multimodal-treatment-strategies-for-anaplastic-and-poorly-differentiated-thyroid-cancer
#1
Sabine Wächter, Annette Wunderlich, Silvia Roth, Ioannis Mintziras, Elisabeth Maurer, Sebastian Hoffmann, Frederik A Verburg, Sebastian A Fellinger, Katharina Holzer, Detlef K Bartsch, Pietro Di Fazio
The prognosis of anaplastic (ATC) and poorly differentiated thyroid cancer (PDTC) is poor, due to their radioiodine refractoriness (RAI-R), high metastatic potential and current lack of effective treatment strategies. We aimed to examine the efficacy of the tyrosine kinase inhibitors (TKIs) sorafenib and selumetinib and the histone deacetylase inhibitor (HDACI) panobinostat in patient-derived tumor tissue (PDTT) of ATCs/PDTCs, the expression of sodium iodide symporter ( NIS ) and radioiodine up-take (RAI-U)...
May 15, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29742752/cross-sectional-and-longitudinal-associations-of-systolic-blood-pressure-with-quality-of-life-and-depressive-mood-in-older-adults-with-cardiovascular-risk-factors-results-from-the-observational-diast-chf-study
#2
Christoph Herrmann-Lingen, Thomas Meyer, Alexandra Bosbach, Mira L Chavanon, Lina Hassoun, Frank Edelmann, Rolf Wachter
OBJECTIVE: While diagnosed arterial hypertension and antihypertensive medication usually have an adverse impact on quality of life, recent studies suggest that actual blood pressure may be positively related to better well-being. However, data in older patients with cardiovascular risk factors are lacking, for whom such an association may be of particular relevance. METHODS: In 1,300 study participants with cardiovascular risk factors aged 50-85 years (51.5% men, mean age 65...
April 27, 2018: Psychosomatic Medicine
https://www.readbyqxmd.com/read/29717501/sensory-evoked-cortical-potentials-of-the-lower-urinary-tract-in-healthy-men
#3
Stephanie C Knüpfer, Martina D Liechti, Stéphanie van der Lely, Flavia Gregorini, Martin Schubert, Stefan De Wachter, Thomas M Kessler, Ulrich Mehnert
AIMS: To assess the afferent innervation of various locations in the male lower urinary tract (LUT) using sensory evoked cortical potentials (SEPs). METHODS: Twelve healthy men (mean age: 29.6 ± 7.2 years, mean height: 1.8 ± 0.1 m) underwent repetitive slow (0.5 Hz/1 ms) and fast (3 Hz/0.2 ms) electrical stimulations of bladder (dome/trigone) and urethral (proximal/membranous/distal) locations with simultaneous cortical SEP recording (Cz-Fz)...
May 1, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29714428/parents-views-on-toilet-training-a-cross-sectional-study-in-flanders
#4
Tinne Van Aggelpoel, Stefan De Wachter, Guido Van Hal, Kelly Van der Cruyssen, Hedwig Neels, Alexandra Vermandel
AIMS: The goals of this research were to investigate parents' perceptions of toilet training and their beliefs and views on how to toilet train children. METHODS: Questionnaires were provided to parents of healthy children, aged 18-72 months, who were or had just finished toilet training. There were 928 questionnaires returned (38% response rate). After correcting for age compliance with the range stated in the study, 832 parents remained. RESULTS: The data confirm a postponement of the age at which children start to potty train and the age at which they are toilet training...
May 1, 2018: Nursing Children and Young People
https://www.readbyqxmd.com/read/29709329/cranial-growth-in-infants%C3%A2-a-longitudinal-three-dimensional-analysis-of-the-first-months-of-life
#5
Philipp Meyer-Marcotty, Felix Kunz, Tilmann Schweitzer, Barbara Wachter, Hartmut Böhm, Nina Waßmuth, Christian Linz
PURPOSE: In the first months of life, any deviation from a physiological growth pattern can cause skull deformity. As there has not been any longitudinal three-dimensional (3D) study investigating the physiological growth of the infant skull, the aim of the present study was to acquire such data. MATERIALS AND METHODS: We performed 3D stereophotogrammetric scans of 40 infants without cranial asymmetry at four regular 2-month intervals from the 4th to the 10th month of age...
April 11, 2018: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29709099/biomarker-based-phenotyping-of-myocardial-fibrosis-identifies-patients-with-heart-failure-with-preserved-ejection-fraction-resistant-to-the-beneficial-effects-of-spironolactone-results-from-the-aldo-dhf-trial
#6
Susana Ravassa, Tobias Trippel, Doris Bach, Diana Bachran, Arantxa González, Begoña López, Rolf Wachter, Gerd Hasenfuss, Christian Delles, Anna F Dominiczak, Burkert Pieske, Javier Díez, Frank Edelmann
BACKGROUND: Myocardial fibrosis is characterized by excessive cross-linking and deposition of collagen type I and is involved in left ventricular stiffening and left ventricular diastolic dysfunction (LVDD). We investigated whether the effect of spironolactone on LVDD in patients with heart failure with preserved ejection fraction (HFpEF) depends on its effects on collagen cross-linking and/or deposition. METHODS AND RESULTS: We investigated 381 HFpEF patients from the multicentre, randomized, placebo-controlled Aldo-DHF trial with measures of the E:e' ratio...
April 30, 2018: European Journal of Heart Failure
https://www.readbyqxmd.com/read/29707637/guns-germs-and-trees-determine-density-and-distribution-of-gorillas-and-chimpanzees-in-western-equatorial-africa
#7
Samantha Strindberg, Fiona Maisels, Elizabeth A Williamson, Stephen Blake, Emma J Stokes, Rostand Aba'a, Gaspard Abitsi, Anthony Agbor, Ruffin D Ambahe, Parfait C Bakabana, Martha Bechem, Antoine Berlemont, Bruno Bokoto de Semboli, Patrick R Boundja, Nicolas Bout, Thomas Breuer, Genevieve Campbell, Pauwel De Wachter, Marc Ella Akou, Fidel Esono Mba, Anna T C Feistner, Bernard Fosso, Roger Fotso, David Greer, Clement Inkamba-Nkulu, Calixte F Iyenguet, Kathryn J Jeffery, Max Kokangoye, Hjalmar S Kühl, Stephanie Latour, Bola Madzoke, Calixte Makoumbou, Guy-Aimé F Malanda, Richard Malonga, Victor Mbolo, David B Morgan, Prosper Motsaba, Gabin Moukala, Brice S Mowawa, Mizuki Murai, Christian Ndzai, Tomoaki Nishihara, Zacharie Nzooh, Lilian Pintea, Amy Pokempner, Hugo J Rainey, Tim Rayden, Heidi Ruffler, Crickette M Sanz, Angelique Todd, Hilde Vanleeuwe, Ashley Vosper, Ymke Warren, David S Wilkie
We present a range-wide assessment of sympatric western lowland gorillas Gorilla gorilla gorilla and central chimpanzees Pan troglodytes troglodytes using the largest survey data set ever assembled for these taxa: 59 sites in five countries surveyed between 2003 and 2013, totaling 61,000 person-days of fieldwork. We used spatial modeling to investigate major drivers of great ape distribution and population trends. We predicted density across each taxon's geographic range, allowing us to estimate overall abundance: 361,900 gorillas and 128,700 chimpanzees in Western Equatorial Africa-substantially higher than previous estimates...
April 2018: Science Advances
https://www.readbyqxmd.com/read/29706429/heart-failure-subtypes-and-thromboembolic-risk-in-patients-with-atrial-fibrillation-the-prefer-in-af-hf-substudy
#8
Jolanta M Siller-Matula, Ladislav Pecen, Giuseppe Patti, Markus Lucerna, Paulus Kirchhof, Maciej Lesiak, Kurt Huber, Freek W A Verheugt, Irene M Lang, Giulia Renda, Renate B Schnabel, Rolf Wachter, Dipak Kotecha, Jean-Marc Sellal, Miklos Rohla, Fabrizio Ricci, Raffaele De Caterina
BACKGROUND AND OBJECTIVES: To assess thromboembolic and bleeding risks in patients with heart failure (HF) and atrial fibrillation (AF) according to HF type. METHODS: We analyzed 6170 AF patients from the Prevention of thromboembolic events - European Registry in Atrial Fibrillation (PREFER in AF), and categorized patients into: HF with reduced left-ventricular ejection fraction (HFrEF; LVEF < 40%); mid-range EF (HFmrEF; LVEF: 40-49%); lower preserved EF (HFLpEF; LVEF: 50-60%), higher preserved EF (HFHpEF; LVEF > 60%), and no HF...
April 22, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29705650/baroreflex-activation-therapy-for-the-treatment-of-heart-failure-with-reduced-ejection-fraction-in-patients-with-and-without-coronary-artery-disease
#9
Marcel Halbach, William T Abraham, Christian Butter, Anique Ducharme, Didier Klug, William C Little, Hannes Reuter, Jill E Schafer, Michele Senni, Vijay Swarup, Rolf Wachter, Fred A Weaver, Seth J Wilks, Michael R Zile, Jochen Müller-Ehmsen
BACKGROUND: In a randomized trial, baroreflex activation therapy (BAT) improved exercise capacity, quality of life and NT-proBNP in patients with heart failure with reduced ejection fraction (HFrEF). In view of different mechanisms underlying HFrEF, we performed a post-hoc subgroup analysis of efficacy and safety of BAT in patients with and without coronary artery disease (CAD). METHODS AND RESULTS: Patients with left ventricular ejection fraction <35% and NYHA Class III were randomized 1:1 to guideline-directed medical and device therapy alone or plus BAT...
April 21, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29704214/expert-opinion-paper-on-atrial-fibrillation-detection-after-ischemic-stroke
#10
REVIEW
Karl Georg Haeusler, Klaus Gröschel, Martin Köhrmann, Stefan D Anker, Johannes Brachmann, Michael Böhm, Hans-Christoph Diener, Wolfram Doehner, Matthias Endres, Christian Gerloff, Hagen B Huttner, Manfred Kaps, Paulus Kirchhof, Darius Günther Nabavi, Christian H Nolte, Waltraud Pfeilschifter, Burkert Pieske, Sven Poli, Wolf Rüdiger Schäbitz, Götz Thomalla, Roland Veltkamp, Thorsten Steiner, Ulrich Laufs, Joachim Röther, Rolf Wachter, Renate Schnabel
This expert opinion paper on atrial fibrillation detection after ischemic stroke includes a statement of the "Heart and Brain" consortium of the German Cardiac Society and the German Stroke Society. This paper was endorsed by the Stroke Unit-Commission of the German Stroke Society and the German Atrial Fibrillation NETwork. In patients with ischemic stroke, detection of atrial fibrillation should usually lead to a change in secondary stroke prevention, since oral anticoagulation is superior to antiplatelet drugs...
April 27, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29691623/minimally-invasive-versus-open-treatment-for-benign-sporadic-insulinoma-comparison-of-short-term-and-long-term-outcomes
#11
Giulio Belfiori, Dominik Wiese, Stefano Partelli, Sabine Wächter, Elisabeth Maurer, Stefano Crippa, Massimo Falconi, Detlef K Bartsch
BACKGROUND: Benign insulinoma is the most common functioning neuroendocrine tumor of the pancreas, and its incidence is estimated at 0.4%. The treatment of choice is organ-preserving resection. The aim of this study was to compare short-term and long-term outcomes of minimally invasive laparoscopic or robotic enucleation (MIC-EN) and open enucleation (O-EN) for sporadic benign insulinoma. METHODS: A retrospective bi-institutional analysis of 71 patients who underwent an enucleation for sporadic benign insulinoma between 2003 and 2016 was performed...
April 24, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29677053/safety-profile-of-baroreflex-activation-therapy-neo-in-patients-with-resistant-hypertension
#12
Manuel Wallbach, Enrico Böhning, Luca-Yves Lehnig, Charlotte Schroer, Gerhard Anton Müller, Rolf Wachter, Stephan Lüders, Dieter Zenker, Michael Johann Koziolek
OBJECTIVE: Unlike safety data of baroreflex activation therapy device (Rheos), only few data of the currently used second device (Barostim neo) are available and little is reported about common side effects. METHODS: We prospectively analyzed patients with resistant hypertension treated with Barostim neo. A standardized interview regarding side effects of the therapy was performed in routine follow-up visits after device implantation in 42 patients to determine adverse events staged into three degrees...
April 19, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29674598/online-monitoring-of-carbon-dioxide-and-oxygen-in-exhaled-mouse-breath-via-substrate-integrated-hollow-waveguide-fourier-transform-infrared-luminescence-spectroscopy
#13
Felicia Seichter, Erhan Tuetuencue, Tamina Hagemann, Josef Vogt, Ulrich Wachter, Michael Groeger, Sandra Kress, Peter Radermacher, Boris Mizaikoff
Exhaled breath offers monitoring bio markers, as well as diagnosing diseases and therapeutic interventions. In addition, vital functions may be non-invasively monitored on-line. Animal models are frequently used in research for determining novel therapeutic approaches and/or for investigating biological pathways. The exhaled carbon dioxide concentration, exhaled and inhaled oxygen concentration, and the subsequent respiratory quotient (RQ) offer insight into metabolic activity. One may adapt breath sampling systems and equipment designed for human applications to large animal studies, however, such adaptations are usually impossible for small animals due to their minuscule breath volume...
April 20, 2018: Journal of Breath Research
https://www.readbyqxmd.com/read/29668565/the-effects-of-genetic-3-mercaptopyruvate-sulfurtransferase-deficiency-in-murine-traumatic-hemorrhagic-shock
#14
Michael Gröger, Martin Wepler, Ulrich Wachter, Tamara Merz, Oscar McCook, Sandra Kress, Britta Lukaschewski, Sebastian Hafner, Markus Huber-Lang, Enrico Calzia, Michael Georgieff, Noriyuki Nagahara, Csaba Szabó, Peter Radermacher, Clair Hartmann
INTRODUCTION: Hemorrhagic shock is a major cause of death after trauma. An additional blunt chest trauma independently contributes to mortality upon the development of an acute lung injury (ALI) by aggravating pathophysiological consequences of hemorrhagic shock. The maintenance of hydrogen sulfide availability is known to play an important role during hemorrhage and ALI. We therefore tested the impact of a genetic 3-mercaptopyruvate sulfurtransferase mutation (Δ3-MST) in a resuscitated murine model of traumatic-hemorrhagic shock...
April 17, 2018: Shock
https://www.readbyqxmd.com/read/29642859/identification-of-novel-mites-miniature-inverted-repeat-transposable-elements-in-coxiella-burnetii-implications-for-protein-and-small-rna-evolution
#15
Shaun Wachter, Rahul Raghavan, Jenny Wachter, Michael F Minnick
BACKGROUND: Coxiella burnetii is a Gram-negative gammaproteobacterium and zoonotic agent of Q fever. C. burnetii's genome contains an abundance of pseudogenes and numerous selfish genetic elements. MITEs (miniature inverted-repeat transposable elements) are non-autonomous transposons that occur in all domains of life and are thought to be insertion sequences (ISs) that have lost their transposase function. Like most transposable elements (TEs), MITEs are thought to play an active role in evolution by altering gene function and expression through insertion and deletion activities...
April 11, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29621896/stigma-modifies-the-association-between-social-support-and-mental-health-among-sexual-violence-survivors-in-the-democratic-republic-of-congo-implications-for-practice
#16
Karin Wachter, Sarah M Murray, Brian J Hall, Jeannie Annan, Paul Bolton, Judy Bass
BACKGROUND AND OBJECTIVES: The aim of this study was to further understanding of the relationship between social support, internalized and perceived stigma, and mental health among women who experienced sexual violence in the eastern Democratic Republic of Congo (DRC). METHODS: Drawing from baseline survey data collected in eastern DRC, researchers conducted a secondary cross-sectional analysis using data from 744 participants. Regression and moderation analyses were conducted to examine associations between social support variables, felt stigma, and depression, anxiety and posttraumatic stress disorder (PTSD)...
April 6, 2018: Anxiety, Stress, and Coping
https://www.readbyqxmd.com/read/29619838/relationship-between-exercise-intervention-and-no-pathway-in-patients-with-heart-failure-with-preserved-ejection-fraction
#17
Flavia Baldassarri, Edzard Schwedhelm, Dorothee Atzler, Rainer H Böger, Kathrin Cordts, Bernhard Haller, Axel Pressler, Stephan Müller, Christiane Suchy, Rolf Wachter, Hans-Dirk Düngen, Gerd Hasenfuss, Burkert Pieske, Martin Halle, Frank Edelmann, André Duvinage
OBJECTIVE: Elevated levels of arginine derivatives in the NO pathway, such as asymmetric dimethylarginine (ADMA), are related to disease severity and reduced exercise capacity in heart failure. We investigated the influence of exercise intervention on these parameters and on L-arginine (L-Arg) and L-homoarginine (L-hArg) in heart failure with preserved ejection fraction (HFpEF) patients. MATERIAL AND METHODS: Sixty-two patients (65 ± 6 years) were included in this analysis and randomised to supervised endurance/resistance training (ET) or to usual care (UC)...
April 5, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29616745/in-situ-analysis-of-mast-cells-and-dendritic-cells-in-coronary-atherosclerosis-in-chronic-kidney-disease-ckd
#18
D L Wachter, D Neureiter, V Câmpean, K F Hilgers, M Büttner-Herold, C Daniel, K Benz, K Amann
AIMS: Mast cells (MC) and dendritic cells (DC) have immune modulatory function and can influence T-cell activity. Both cell types have been found in atherosclerotic plaques and are thought to play an important role for plaque stability. Compared to matched segments of the non-renal population, patients with chronic kidney disease (CKD) show a more pronounced and more aggressive course of atherosclerosis with higher plaque calcification and significantly higher complications rates. It was the aim of this study to analyze the number and localization of MCs and DCs, macrophages, T- and B-cells as well as the expression of markers of inflammation such as CRP and NFκB in calcified and non-calcified atherosclerotic plaques of patients with CKD and control patients...
April 4, 2018: Histology and Histopathology
https://www.readbyqxmd.com/read/29604852/single-molecule-diffusometry-reveals-the-nucleotide-dependent-oligomerization-pathways-of-nicotiana-tabacum-rubisco-activase
#19
Quan Wang, Andrew J Serban, Rebekka M Wachter, W E Moerner
Oligomerization plays an important role in the function of many proteins, but a quantitative picture of the oligomer distribution has been difficult to obtain using existing techniques. Here we describe a method that combines sub-stoichiometric labeling and recently developed single-molecule diffusometry to measure the size distribution of oligomers under equilibrium conditions in solution, one molecule at a time. We use this technique to characterize the oligomerization behavior of Nicotiana tabacum (Nt) Rubisco activase (Nt-Rca), a chaperone-like AAA-plus ATPase essential in regulating carbon fixation during photosynthesis...
March 28, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29600336/-atrial-fibrillation-as-a-comorbidity-of-heart-failure
#20
REVIEW
R Wachter
Atrial fibrillation and heart failure are diseases that frequently occur together in patients, and the prevalence of the two diseases will continue to increase in the future. Unfortunately, they exacerbate each other: the prognosis of patients with atrial fibrillation is poorer if there is heart failure, and the prognosis of heart failure patients with atrial fibrillation is poorer than the prognosis of heart failure patients without atrial fibrillation. In the past, studies on drug stabilization of sinus rhythm with antiarrhythmic drugs were not able to show any influence on the prognosis of patients...
March 29, 2018: Der Internist
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