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https://www.readbyqxmd.com/read/28551850/microrna-211-expression-is-down-regulated-and-associated-with-poor-prognosis-in-human-glioma
#1
Jun Zhang, Jianguang Lv, Feng Zhang, Hongmin Che, Qiwei Liao, Wobin Huang, Shaopeng Li, Yuqian Li
Accumulating evidence has supported the role of microRNAs in the initiation and development of malignant tumors. MicroRNA-211 (miR-211), which was reported to involve in diverse physiological activities in several cancers, was investigated for its expression in human glioma and adjacent normal brain tissues, as well as its correlation with patient prognosis. Glioma tissues and adjacent normal brain tissues were obtained from 82 patients who underwent surgical resection, and quantitative real-time polymerase chain reaction was performed to assess the expression level of miR-211...
May 27, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28551777/large-scale-functional-neural-network-correlates-of-response-inhibition-an-fmri-meta-analysis
#2
Ruibin Zhang, Xiujuan Geng, Tatia M C Lee
An influential hypothesis from the last decade proposed that regions within the right inferior frontal cortex of the human brain were dedicated to supporting response inhibition. There is growing evidence, however, to support an alternative model, which proposes that neural areas associated with specific inhibitory control tasks co-exist as common network mechanisms, supporting diverse cognitive processes. This meta-analysis of 225 studies comprising 323 experiments examined the common and distinct neural correlates of cognitive processes for response inhibition, namely interference resolution, action withholding, and action cancellation...
May 27, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28551767/does-rarity-mean-imparity-biological-characteristics-of-osteosarcoma-cells-originating-from-the-spine
#3
Zhenhua Zhou, Yan Li, Xu Yan, Xudong Wang, Cheng Yang, Haifeng Wei, Xinghai Yang, Jianru Xiao
PURPOSE: Osteosarcoma is one of the most common malignancies in bones and is often found in limbs. Until now, it is not clear why osteosarcoma is rare in the spine. On the other hand, previous biological characteristics study about osteosarcoma of spine was also rare because of its low incidence. To explore the biology of spinal osteosarcoma, a stable osteosarcoma cell line derived from spine is necessary. METHODS: A novel osteosarcoma cell line named NEO217 was established from spinal osteosarcoma tissues obtained from a Chinese male patient...
May 27, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28551763/mesenchymal-stromal-cell-and-osteoblast-responses-to-oxidized-titanium-surfaces-pre-treated-with-%C3%AE-%C3%A2-%C3%A2-808%C3%A2-nm-gaalas-diode-laser-or-chlorhexidine-in-vitro-study
#4
Flaminia Chellini, Marco Giannelli, Alessia Tani, Lara Ballerini, Larissa Vallone, Daniele Nosi, Sandra Zecchi-Orlandini, Chiara Sassoli
Preservation of implant biocompatibility following peri-implantitis treatments is a crucial issue in odontostomatological practice, being closely linked to implant re-osseointegration. Our aim was to assess the responses of osteoblast-like Saos2 cells and adult human bone marrow-mesenchymal stromal cells (MSCs) to oxidized titanium surfaces (TiUnite(®), TiU) pre-treated with a 808 ± 10 nm GaAlAs diode laser operating in non-contact mode, in continuous (2 W, 400 J/cm(2); CW) or pulsed (20 kHz, 7 μs, 0...
May 27, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28551742/human-health-risk-exposure-with-respect-to-particulate-bound-polycyclic-aromatic-hydrocarbons-at-mine-fire-affected-coal-mining-complex
#5
Debananda Roy, Yong-Chil Seo, Sweta Sinha, Abir Bhattacharya, Gurdeep Singh, Pallab Kr Biswas
Particulate-bound poly-aromatic hydrocarbons (PAHs) are of great concern due to their mutagenicity and carcinogenicity effect on human health. In this context, identification, quantification and inhalation cancer risk (ICR) assessment due to PM10- and PM2.5-bound PAHs has been carried out at six monitoring stations in a critically polluted Jharia coalfield/Dhanbad City. Identification of pollution sources at study area has been performed by using PCA statistical methods. Air quality index (AQI) and air quality health index (AQHI) were calculated based on the concentration levels of PM10...
May 27, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28551711/why-are-most-phospholipidosis-inducers-also-herg-blockers
#6
Svetoslav Slavov, Iva Stoyanova-Slavova, Shuaizhang Li, Jinghua Zhao, Ruili Huang, Menghang Xia, Richard Beger
Recent reports have noted that a number of compounds that block the human Ether-à-go-go related gene (hERG) ion channel also induce phospholipidosis (PLD). To explore a hypothesis explaining why most PLD inducers are also hERG inhibitors, a modeling approach was undertaken with data sets comprised of 4096 compounds assayed for hERG inhibition and 5490 compounds assayed for PLD induction. To eliminate the chemical domain effect, a filtered data set of 567 compounds tested in quantitative high-throughput screening (qHTS) format for both hERG inhibition and PLD induction was constructed...
May 27, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28551698/glucose-metabolism-during-rotational-shift-work-in-healthcare-workers
#7
Anu Sharma, Marcello C Laurenti, Chiara Dalla Man, Ron T Varghese, Claudio Cobelli, Robert A Rizza, Aleksey Matveyenko, Adrian Vella
AIMS/HYPOTHESIS: Shift-work is associated with circadian rhythm disruption and an increased risk of obesity and type 2 diabetes. We sought to determine the effect of rotational shift-work on glucose metabolism in humans. METHODS: We studied 12 otherwise healthy nurses performing rotational shift-work using a randomised crossover study design. On each occasion, participants underwent an isotope-labelled mixed meal test during a simulated day shift and a simulated night shift, enabling simultaneous measurement of glucose flux and beta cell function using the oral minimal model...
May 27, 2017: Diabetologia
https://www.readbyqxmd.com/read/28551696/zinc-finger-e-box-binding-protein-2-zeb2-suppress-apoptosis-of-vascular-endothelial-cells-induced-by-high-glucose-through-mitogen-activated-protein-kinases-mapk-pathway-activation
#8
Lin-Jun Wang, Zi-Heng Wu, Xiang-Tao Zheng, Jian-Yun Long, Yang-Min Dong, Xin Fang
BACKGROUND Hyperglycemia has been confirmed to damage endothelial function of vascular and microvascular. The regulation of zinc finger E-box binding protein 2 (ZEB2) on vascular endothelial cells (VECs) is reported rarely. Our study investigates the role of ZEB2 on the apoptosis of VECs induced by high glucose through MAPK pathway. MATERIAL AND METHODS Downregulated and upregulated expression of ZEB2 in human umbilical vein endothelial cells (HUVECs) were performed by plasmids transfection. HUVECs are respectively treated with different concentrations of glucose (5...
May 28, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28551636/identification-of-micrornas-involved-in-resistance-to-sunitinib-in-renal-cell-carcinoma-cells
#9
Noriya Yamaguchi, Mitsuhiko Osaki, Kunishige Onuma, Tetsuya Yumioka, Hideto Iwamoto, Takehiro Sejima, Hiroyuki Kugoh, Atsushi Takenaka, Futoshi Okada
AIM: To generate sunitinib-resistant renal cell carcinoma (RCC) cell lines and identify miRNAs contributing to sunitinib resistance. MATERIALS AND METHODS: Two RCC cell lines, ACHN and RCC23, were cultured by continuous treatment with sunitinib for 3 months, with doses gradually increasing up to the 50% inhibitory concentration for each cell line. We performed microarray and quantitative real-time polymerase chain reaction analyses of sunitinib-resistant ACHN (SR-ACHN) and RCC23 (SR-RCC23) cells, as well of as sunitinib-sensitive ACHN and RCC23 cells...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551577/bioactive-growth-hormone-in-older-men-and-women-it-s-relationship-to-immune-markers-and-healthspan
#10
William J Kraemer, Mary J Kennett, Andrea M Mastro, Roger J McCarter, Connie J Rogers, William H DuPont, Shawn D Flanagan, William J Turbitt, Maren S Fragala, Emily M Post, Wesley C Hymer
OBJECTIVE: The consequences of age-related decline in the somatotropic axis of humans are complex and remain largely unresolved. We tested the hypothesis that hGH measurements of plasma by bioassay vs immunoassay from samples obtained from free-living, elderly individuals would reveal a dichotomy in GH activities that are correlated with the functional status of the donors, i.e. their healthspan. DESIGN: Forty-one men and women of advanced age (men: N=16, age, 80...
May 8, 2017: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/28551545/cytotoxicity-of-temozolomide-on-human-glioblastoma-cells-is-enhanced-by-the-concomitant-exposure-to-an-extremely-low-frequency-electromagnetic-field-100hz-100g
#11
Zeinab Akbarnejad, Hossein Eskandary, Luciana Dini, Cristian Vergallo, Seyed Noureddin Nematollahi-Mahani, Alireza Farsinejad, Maryam Fekri Soofi Abadi, Meysam Ahmadi
Glioblastoma multiforme (GBM) is the most malignant brain cancer that causes high mortality in humans. It responds poorly to the most common cancer treatments, such as surgery, chemo- and radiation therapy. Temozolomide (TMZ) is an alkylating agent that has been widely used to treat GBM; resistance to this drug is often found. One unexplored possibility for overcoming this resistance is a treatment based on concomitant exposure to electromagnetic fields (EMF) and TMZ. Indeed, many evidences show that EMF affects cancer cells and drug performance...
May 24, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28551509/bacteriophage-removal-efficiency-as-a-validation-and-operational-monitoring-tool-for-virus-reduction-in-wastewater-reclamation-review
#12
REVIEW
Mohan Amarasiri, Masaaki Kitajima, Thanh H Nguyen, Satoshi Okabe, Daisuke Sano
The multiple-barrier concept is widely employed in international and domestic guidelines for wastewater reclamation and reuse for microbiological risk management, in which a wastewater reclamation system is designed to achieve guideline values of the performance target of microbe reduction. Enteric viruses are one of the pathogens for which the target reduction values are stipulated in guidelines, but frequent monitoring to validate human virus removal efficacy is challenging in a daily operation due to the cumbersome procedures for virus quantification in wastewater...
May 19, 2017: Water Research
https://www.readbyqxmd.com/read/28551381/a-specific-mutational-signature-associated-with-dna-8-oxoguanine-persistence-in-mutyh-defective-colorectal-cancer
#13
Alessandra Viel, Alessandro Bruselles, Ettore Meccia, Mara Fornasarig, Michele Quaia, Vincenzo Canzonieri, Eleonora Policicchio, Emanuele Damiano Urso, Marco Agostini, Maurizio Genuardi, Emanuela Lucci-Cordisco, Tiziana Venesio, Aline Martayan, Maria Grazia Diodoro, Lupe Sanchez-Mete, Vittoria Stigliano, Filomena Mazzei, Francesca Grasso, Alessandro Giuliani, Marta Baiocchi, Roberta Maestro, Giuseppe Giannini, Marco Tartaglia, Ludmil B Alexandrov, Margherita Bignami
8-Oxoguanine, a common mutagenic DNA lesion, generates G:C>T:A transversions via mispairing with adenine during DNA replication. When operating normally, the MUTYH DNA glycosylase prevents 8-oxoguanine-related mutagenesis by excising the incorporated adenine. Biallelic MUTYH mutations impair this enzymatic function and are associated with colorectal cancer (CRC) in MUTYH-Associated Polyposis (MAP) syndrome. Here, we perform whole-exome sequencing that reveals a modest mutator phenotype in MAP CRCs compared to sporadic CRC stem cell lines or bulk tumours...
April 13, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28551362/an-evaluation-of-different-measures-of-color-saturation
#14
Florian Schiller, Matteo Valsecchi, Karl R Gegenfurtner
We investigated how well seven saturation measures defined in CIECAM02, HSV, DKL, LAB, LUV, and CIE 1931 xyY color spaces correspond to human perception of saturation. We used a paradigm that allowed us to measure the perceived saturation of several standard color stimuli in many different directions of color space. We implemented this paradigm at different levels of luminance and varied background luminance relative to the luminance of our color stimuli in order to ensure the generality of our approach. We found that varying background luminance changed the relative saturation of the standard colors...
May 24, 2017: Vision Research
https://www.readbyqxmd.com/read/28551328/association-of-expression-of-the-hedgehog-signal-with-merkel-cell-polyomavirus-infection-and-prognosis-of-merkel-cell-carcinoma
#15
Teruyuki Kuromi, Michiko Matsushita, Takeshi Iwasaki, Daisuke Nonaka, Satoshi Kuwamoto, Keiko Nagata, Masako Kato, Gen Akizuki, Yukisato Kitamura, Kazuhiko Hayashi
Merkel cell carcinoma (MCC) is an aggressive neuroendocrine skin cancer that mostly occurs in the elderly. Merkel cell polyomavirus (MCPyV) is detected in approximately 80% of MCCs and is associated with carcinogenesis. Hedgehog signaling pathway plays a role in human embryogenesis and organogenesis. In addition, reactivation of this pathway later in life can cause tumors. 29 MCPyV-positive and 21 MCPyV-negative MCCs were immunohistochemically stained with primary antibodies for hedgehog signaling (SHH, IHH, PTCH1, SMO, GLI1, GLI2, and GLI3) and evaluated using H-score...
May 24, 2017: Human Pathology
https://www.readbyqxmd.com/read/28551275/genetic-analysis-of-vcp-and-wash-complex-genes-in-a-german-cohort-of-sporadic-als-ftd-patients
#16
Matthias Türk, Rolf Schröder, Katharina Khuller, Andreas Hofmann, Carolin Berwanger, Albert C Ludolph, Gabriele Dekomien, Kathrin Müller, Jochen H Weishaupt, Christian T Thiel, Christoph S Clemen
Mutations of the human valosin-containing protein, p97 (VCP) and Wiskott-Aldrich syndrome protein and SCAR homolog (WASH) complex genes cause motor neuron and cognitive impairment disorders. Here, we analyzed a cohort of German patients with sporadic amyotrophic lateral sclerosis and frontotemporal lobar degeneration comorbidity (ALS/FTD) for VCP and WASH complex gene mutations. Next-generation panel sequencing of VCP, WASH1, FAM21C, CCDC53, SWIP, strumpellin, F-actin capping protein of muscle Z-line alfa 1 (CAPZA1), and CAPZB genes was performed in 43 sporadic ALS/FTD patients...
May 3, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28551115/mos2-tio2-sinw-surface-as-an-effective-substrate-for-ldi-ms-detection-of-glucose-and-glutathione-in-real-samples
#17
Abderrahmane Hamdi, Ioana Silvia Hosu, Ahmed Addad, Ruben Hartkoorn, Hervé Drobecq, Oleg Melnyk, Hatem Ezzaouia, Rabah Boukherroub, Yannick Coffinier
Here, we report for the first time, the use of molybdenum disulfide/titanium oxide/silicon nanowires (MoS2/TiO2/SiNW) surfaces for SALDI-MS detection as alternative to MALDI-MS method. Silicon nanowires were fabricated by the well-known metal-assisted chemical etching process followed by the deposition of TiO2 by atomic layer deposition. MoS2 deposition was achieved through hydrothermal treatment. The MoS2/TiO2/SiNW substrate has shown high performance for the detection of small compounds of different molecular weights, including glutathione, glucose, amino acids, antibiotics to name a few...
August 15, 2017: Talanta
https://www.readbyqxmd.com/read/28551097/how-to-best-support-sit-to-stand-transfers-of-geriatric-patients-motion-optimization-under-external-forces-for-the-design-of-physical-assistive-devices
#18
Katja Mombaur, Khai-Long Ho Hoang
Sit to stand (STS) transfers form a challenging type of motion, in particular for geriatric patients. Physical assistive devices that are built to enhance the mobility of this class of patients therefore must especially be able to support STS transfers. This paper presents a method to predict geriatric STS movements and compute the best possible actions by external devices to support these movements. We treat three types of active devices that act on different parts of the patient's body and provide different levels of support...
May 17, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28551013/citrus-nomilin-down-regulates-tnf-%C3%AE-induced-proliferation-of-aortic-smooth-muscle-cells-via-apoptosis-and-inhibition-of-i%C3%AE%C2%BAb
#19
Jinhee Kim, Sanjukta Chakraborty, G K Jayaprakasha, Mariappan Muthuchamy, Bhimanagouda S Patil
Nomilin is a bitter compound present in citrus and has been demonstrated as useful for various disease preventions through anti-proliferative, anti-inflammatory, and pro-apoptotic activities. Although in vitro disease models have shown that certain limonoids in the p38 mitogen-activated protein kinase signal cascade, the downstream signaling pathways remain unclear. In this study, the effects of nomilin on the proliferation and apoptotic pathways of human aortic smooth muscle cells (HASMCs) that forms the basis of progression of atherosclerotic diseases and restenosis was tested for the first time...
May 24, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28550806/lettuce-facing-microcystins-rich-irrigation-water-at-different-developmental-stages-effects-on-plant-performance-and-microcystins-bioaccumulation
#20
Efi Levizou, George Statiris, Theodoti Papadimitriou, Chrysi S Laspidou, Konstantinos Ar Kormas
This study investigated the microcystins (MCs)-rich irrigation water effect on lettuce of different developmental stages, i.e. during a two months period, covering the whole period from seed germination to harvest at marketable size of the plant. We followed four lettuce plant groups receiving MCs-rich water (1.81μgl(-1) of dissolved MCs), originating from the Karla Reservoir, central Greece: 1) from seeds, 2) the cotyledon, 3) two true leaves and 4) four true leaves stages, all of which were compared to control plants that received tap water...
May 24, 2017: Ecotoxicology and Environmental Safety
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