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liver function after liver transplantation

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https://www.readbyqxmd.com/read/29029891/imaging-findings-within-the-first-12%C3%A2-months-of-hepatocellular-carcinoma-treated-with-stereotactic-body-radiation-therapy
#1
Mishal Mendiratta-Lala, Everett Gu, Dawn Owen, Kyle C Cuneo, Latifa Bazzi, Theodore S Lawrence, Hero K Hussain, Matthew S Davenport
PURPOSE: To correlate the imaging findings of treated hepatocellular carcinoma (HCC) after stereotactic body radiation therapy (SBRT) with explant pathology and alpha-fetoprotein (AFP) response. METHODS AND MATERIALS: From 2007 to 2015, of 146 patients treated with liver SBRT for Barcelona Clinic Liver Cancer stage A hepatocellular carcinoma, 10 were identified with inclusion criteria and had regular interval follow-up magnetic resonance imaging/triple phase computed tomography and explant pathology or declining AFP values for radiology-pathology response correlation...
August 24, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29026966/the-clinical-implications-of-liver-resection-margin-size-in-patients-with-hepatocellular-carcinoma-in-terms-of-positron-emission-tomography-positivity
#2
Jae Hyun Park, Dong Hwi Kim, Sung Hoon Kim, Moon Young Kim, Soon Koo Baik, In Su Hong
BACKGROUND: The positivity of positron emission tomography (PET) in hepatocellular carcinoma (HCC) correlates with aggressive tumor factors and poor survival. Adequate resection margin size is still a topic of debate. We analyzed the clinical implications of resection margin size in patients with HCC in terms of PET positivity. METHODS: We retrospectively reviewed the medical records of 92 patients who underwent liver resection from March 2012 to October 2015. We investigated prognostic factors for recurrence and survival...
October 12, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29026064/the-effect-of-recipient-body-mass-index-and-its-extremes-on-survival-and-graft-vascular-and-biliary-complications-after-liver-transplantation-a-single-center-retrospective-study
#3
Emmanouil Giorgakis, Michele Tedeschi, Eliano Bonaccorsi-Riani, Shirin Elizabeth Khorsandi, Krishna Menon, Hector Vilca-Melendez, Wayel Jassem, Parthi Srinivasan, Andreas Prachalias, Nigel Heaton
BACKGROUND This is the largest UK-based study on the effect of recipient body mass index (BMI) and its extremes (BMI <18.5 and BMI ≥35 kg/m²) on liver transplant (LT) outcomes. Its purpose was to analyze the BMI effect on post-LT mortality, graft loss, primary non-function (PNF), and graft vascular and biliary complications. MATERIAL AND METHODS Data were retrieved from a single-center LT database of 2,115 consecutive patients receiving first LT during period February 2004 to September 2015. Survivals were compared across the BMI groups; the effects of recipient BMI on survival, PNF, and graft vascular and biliary complications were analyzed via regression...
October 13, 2017: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/29023905/cholangiopathy-in-critically-ill-patients-surviving-beyond-the-intensive-care-period-a-multicentre-survey-in-liver-units
#4
L Laurent, C Lemaitre, A Minello, A Plessier, G Lamblin, A Poujol-Robert, A Gervais-Hasenknopf, E-A Pariente, P Belenotti, N Mostefa-Kara, P Sogni, M Legrand, J-M Cournac, F Tamion, G Savoye, P Bedossa, D-C Valla, V Vilgrain, O Goria
BACKGROUND: The outcome of cholangiopathy developing in intensive care unit (ICU) is not known in patients surviving their ICU stay. AIM: To perform a survey in liver units, in order to clarify the course of cholangiopathy after surviving ICU stay. METHODS: The files of the liver units affiliated to the French network for vascular liver disease were screened for cases of ICU cholangiopathy developing in patients with normal liver function tests on ICU admission, and no prior history of liver disease...
October 11, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29018070/hypothermic-oxygenated-machine-perfusion-hope-for-orthotopic-liver-transplantation-of-human-liver-allografts-from-extended-criteria-donors-ecd-in-donation-after-brain-death-dbd-a-prospective-multicentre-randomised-controlled-trial-hope-ecd-dbd
#5
Zoltan Czigany, Wenzel Schöning, Tom Florian Ulmer, Jan Bednarsch, Iakovos Amygdalos, Thorsten Cramer, Xavier Rogiers, Irinel Popescu, Florin Botea, Jiří Froněk, Daniela Kroy, Alexander Koch, Frank Tacke, Christian Trautwein, Rene H Tolba, Marc Hein, Ger H Koek, Cornelis H C Dejong, Ulf Peter Neumann, Georg Lurje
INTRODUCTION: Orthotopic liver transplantation (OLT) has emerged as the mainstay of treatment for end-stage liver disease. In an attempt to improve the availability of donor allografts and reduce waiting list mortality, graft acceptance criteria were extended increasingly over the decades. The use of extended criteria donor (ECD) allografts is associated with a higher incidence of primary graft non-function and/or delayed graft function. As such, several strategies have been developed aiming at reconditioning poor quality ECD liver allografts...
October 10, 2017: BMJ Open
https://www.readbyqxmd.com/read/29017655/-application-of-active-immunization-in-the-prevention-of-de-novo-hepatitis-b-virus-infection-after-pediatric-liver-transplantation-with-hbcab-positive-donor-liver
#6
Yufeng Cui, Wei Lu, Wei Gao, Chong Dong, Chao Han, Yihe Liu
OBJECTIVE: To investigate the effect of active immunization on prevention of post-transplantation de novo hepatitis B virus (HBV) infection in patients receiving liver grafts from hepatitis B core antibody (HBcAb) positive donors. METHODS: A retrospective analysis was conducted. Eighty-seven children undergoing liver transplantation from HBcAb positive donors admitted to Tianjin First Center Hospital from October 2012 to December 2016 were enrolled, and the data of donors and recipients were collected...
October 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28992880/delayed-introduction-of-immunosuppressive-regimens-in-critically-ill-patients-after-liver-transplantation
#7
Ying Luo, Wen-Bin Ji, Wei-Dong Duan, Xian-Jie Shi, Zhi-Ming Zhao
BACKGROUND: The manipulation of immunosuppression therapy remains challenging in patients who develop infectious diseases or multiple organ dysfunction after liver transplantation. We evaluated the outcomes of delayed introduction of immunosuppression in the patients after liver transplantation under immune monitoring with ImmuKnow assay. METHODS: From March 2009 to February 2014, 225 consecutive liver recipients in our institute were included. The delayed administration of immunosuppressive regimens was attempted in 11 liver recipients with multiple severe comorbidities...
October 15, 2017: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/28991124/angiogenesis-in-the-transplanted-donor-graft-after-living-donor-liver-transplantation
#8
Dong-Hwan Jung, Sung-Hwan Moon, Soon-Jung Park, Eun Jae Kim, In Ho Jang, Cheon-Soo Park, Ji Yoon Lee, Yong-Pil Cho, Sung-Gyu Lee
BACKGROUND: There is no direct evidence for the role of angiogenesis in liver regeneration in humans. This study aimed to determine whether angiogenesis is involved in the regeneration of transplanted donor grafts in human living-donor liver transplantation (LDLT) and to examine the impact of donor graft volume on angiogenesis. METHODS: Clinical data and liver tissue characteristics were analyzed in 4 patients who received adult-to-adult LDLT with dual left lobe grafts from 2 living donors...
October 5, 2017: Transplantation
https://www.readbyqxmd.com/read/28989060/metroticket-2-0-model-for-analysis-of-competing-risks-of-death-following-liver-transplantation-for-hepatocellular-carcinoma
#9
Vincenzo Mazzaferro, Carlo Sposito, Jian Zhou, Antonio D Pinna, Luciano De Carlis, Jia Fan, Matteo Cescon, Stefano Di Sandro, He Yi-Feng, Andrea Lauterio, Marco Bongini, Alessandro Cucchetti
BACKGROUND & AIMS: Outcomes of liver transplantation for hepatocellular carcinoma (HCC) are determined by cancer-related and non-related events. Treatments for hepatitis C virus (HCV) infection have reduced non-cancer events among patients receiving liver transplants, so reducing HCC-related death might be an actionable endpoint. We performed a competing risk analysis to evaluate factors associated with survival of patients with HCC, and developed a prognostic model based on features of HCC patients before liver transplantation...
October 5, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28970712/liver-transplantation-for-acute-on-chronic-liver-failure
#10
Narendra S Choudhary, Neeraj Saraf, Sanjiv Saigal, Arvinder S Soin
BACKGROUND: Acute-on chronic liver failure (ACLF) is defined as acute insult on previous liver disease that causes sudden worsening of liver functions. METHODS: ACLF is characterized by high incidence of organ failure and prognosis is remarkably worse than patients with cirrhosis. Incidence of organ failures is very high despite best medical care and timely liver transplant before development of multi organ failure is associated with good survival rates. RESULTS: At present, there are no reliable score or ways to correctly identify patients who are going to recover from patients who will need transplantation...
September 2017: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/28970711/is-portal-venous-pressure-or-porto-systemic-gradient-really-a-harbinger-of-poor-outcomes-after-living-donor-liver-transplantation
#11
Amol Vijay Kanetkar, Dinesh Balakrishnan, Sudhindran Sudhindran, Puneet Dhar, Unnikrishnan Gopalakrishnan, Ramachandran Menon, Othiyil Vayoth Sudheer
BACKGROUND: Portal hyperperfusion as a cause of small for size syndrome (SFSS) after living donor liver transplantation (LDLT) remains controversial. Portal venous pressure (PVP) is often measured indirectly and may be confounded by central venous pressure (CVP). METHODS: In 42 adult cirrhotics undergoing elective LDLT, PVP was measured by direct canulation of portal vein and porto systemic gradient (PSG) was obtained after subtracting CVP from PVP. None underwent portal inflow modulation...
September 2017: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/28970707/role-of-human-wharton-s-jelly-derived-mesenchymal-stem-cells-wj-mscs-for-rescue-of-d-galactosamine-induced-acute-liver-injury-in-mice
#12
Raghu Ramanathan, Secunda Rupert, Sakthivel Selvaraj, Jeswanth Satyanesan, Rosy Vennila, Surendran Rajagopal
BACKGROUND/AIM: Mesenchymal stem cells (MSCs) are multipotent precursor cells having self-renewal ability making them a candidate for use in regenerative medicine. Acute liver injury results in sudden loss of hepatic function leading to organ failure. Liver transplantation is often required to salvage patients with acute liver failure. Due to shortage of organs, identification of alternate method is the need of the hour. In view of this, an attempt has been made to check the regenerative ability of WJ-MSCs (wharton's jelly derived MSC) in mice models for acute liver injury...
September 2017: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/28969526/evaluating-mrna-expression-levels-of-the-tlr4-irf5-signaling-axis-during-hepatic-ischemia-reperfusion-injuries
#13
Meysam Nasiri, Mostafa Saadat, Mohammad-Hossein Karimi, Negar Azarpira, Iraj Saadat
OBJECTIVES: Hepatic ischemia and reperfusion during liver transplant surgery result in hepatocellular damage. Toll-like receptors, especially TLR4, have a fundamental basic role in the inflammatory phase of ischemia-reperfusion injuries. The effect of the TRIF-dependent signaling pathway downstream of TLR4 in hepatic ischemia-reperfusion injury has been well established. However, the role of TLR4-MyD88-dependent signal transduction in hepatic ischemia-reperfusion injury has not yet been clarified...
September 30, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28965313/significant-liver-related-morbidity-after-bariatric-surgery-and-its-reversal-a-case-series
#14
Magdalena Eilenberg, Felix B Langer, Andrea Beer, Michael Trauner, Gerhard Prager, Katharina Staufer
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) occurs in up to 80% of patients with obesity. Current data suggest an improvement of NAFLD after established bariatric procedures. OBJECTIVES: This study investigated liver function impairment after Roux-en-Y gastric bypass (RYGB) and one-anastomosis gastric bypass (OAGB). SETTING: University Hospital, Bariatric Surgery Unit METHODS: In this single-center case series, consecutive in- and outpatients after bariatric surgery who presented with severe liver dysfunction from March 2014 to February 2017 were included and followed until March 2017...
September 30, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28960647/long-term-fate-of-human-fetal-liver-progenitor-cells-transplanted-in-injured-mouse-livers
#15
Antony Irudayaswamy, Mark Muthiah, Lei Zhou, Hau Hung, Nur Halisah Bte Jumat, Jamil Haque, Narcissus Teoh, Geoffrey Farrell, Kimberly J Riehle, Jaymie Siqi Lin, Lin Lin Su, Jerry Ky Chan, Mahesh Choolani, Peng Cheang Wong, Aileen Wee, Seng Gee Lim, Jean Campbell, Nelson Fausto, Yock Young Dan
Liver progenitor cells have the potential to repair and regenerate a diseased liver. The success of any translational efforts, however, hinges on thorough understanding of the fate of these cells after transplant, especially in terms of long-term safety and efficacy. Here, we report transplantation of a liver progenitor population isolated from human fetal livers into immune-permissive mice with follow-up up to 36 weeks after transplant. We found that human progenitor cells engraft and differentiate into functional human hepatocytes in the mouse, producing albumin, alpha-1-antitrypsin, and glycogen...
September 28, 2017: Stem Cells
https://www.readbyqxmd.com/read/28960366/portal-pressure-and-liver-stiffness-measurements-in-the-prediction-of-fibrosis-regression-after-svr-in-recurrent-hepatitis-c
#16
Ezequiel Mauro, Gonzalo Crespo, Carla Montironi, Maria-Carlota Londoño, Virginia Hernández-Gea, Pablo Ruiz, Lydia Sastre, Julissa Lombardo, Zoe Mariño, Alba Díaz, Jordi Colmenero, Antoni Rimola, Juan Carlos Garcia-Pagan, Mercé Brunet, Xavier Forns, Miquel Navasa
Sustained virological response (SVR) improves survival in post liver transplant (LT) recurrent hepatitis C. However, the impact of SVR on fibrosis regression is not well defined. In addition, the performance of noninvasive methods to evaluate the presence of fibrosis and portal hypertension after SVR has been scarcely evaluated. We aimed to investigate the degree of fibrosis regression (decrease ≥1 METAVIR stage) after SVR and its associated factors in recurrent hepatitis C, as well as the diagnostic capacity of noninvasive methods in the assessment of liver fibrosis and portal hypertension after viral clearance...
September 27, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28951512/efficacy-of-oral-vancomycin-in-recurrent-primary-sclerosing-cholangitis-following-liver-transplantation
#17
Penelope Hey, Julie Lokan, Paul Johnson, Paul Gow
Primary sclerosing cholangitis (PSC) is a liver disease that leads to progressive destruction and stricturing of the biliary tree. Unfortunately, apart from orthotopic liver transplantation (OLT), there are no universally accepted therapies to treat this disease. Even following transplantation, recurrence of PSC is seen in approximately one quarter of patients and leads to high rates of graft failure. Oral vancomycin, through possible immunomodulatory and anti-inflammatory mechanisms, has been shown in small-scale studies to be successful in improving liver function tests in patients with pretransplant PSC...
September 25, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28948755/hepatitis-c-and-liver-transplantation
#18
Silvia Martini
Hepatitis C virus (HCV)-related liver disease represents the leading indication for liver transplantation (LT) in the United States and Europe and HCV recurrence is universal in recipients who are viremic at LT. Until a few years ago, pegylated-interferon in association with ribavirin was the only therapeutic strategy, usable only in compensated cirrhotic patients, in order to prevent post-LT viral recurrence. The recent advent of direct-acting antiviral agents (DAAs) has dramatically increased the chances of curative treatment for the transplant population and the debate about which should be the best time for treating the infection is still open: whether to pursue HCV eradication a) before LT, in order to improve liver function, delist some patients and prevent graft infection, or b) as early as possible after LT, rather than c) waiting for hepatitis C recurrence before starting treatment...
September 25, 2017: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/28944999/systemic-redistribution-of-the-intramyocardially-injected-mesenchymal-stem-cells-by-repeated-remote-ischaemic-post-conditioning
#19
Qin Jiang, Tao Yu, Keli Huang, Hao Zhang, Zhe Zheng, Shengshou Hu
We investigated the effect of repeated remote ischaemic post-conditioning (RIPoC) on the organ distribution of the intramyocardially injected MSCs in rat myocardial ischemia model. Myocardial ischemia of adult female Sprague-Dawley rats was induced by 30-min. obstruction of the left anterior descending coronary artery. Repeated RIPoC was induced after ischemia with three cycles of 5-min. occlusion and reperfusion of the limb with the frequency of half a day, 1 or 2 days, respectively. Compared with that by single RIPoC, repeated RIPoC transiently reduced oxidative stress, lipid peroxidation and inflammation in ischaemic myocardium; the gene expression of stromal cell-derived factor-1 alpha (SDF-1α) was consistently induced by repeated RIPoC procedures...
September 25, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28943540/amyloid-polyneuropathy-and-myocardial-amyloidosis-10-years-after-domino-liver-transplantation-from-a-patient-with-a-transthyretin-ser50arg-mutation
#20
Masaaki Matsushima, Ichiro Yabe, Masaya Tsuda, Mamoru Sakakibara, Tsuyoshi Shimamura, Hidenao Sasaki
A 54-year-old man with polycystic liver disease received a domino liver transplantation (DLT) from a patient of hereditary ATTR amyloidosis with the transthyretin Ser50Arg mutation. Ten years after transplantation, he felt a slight numbness in his toes, and cardiac amyloidosis was simultaneously suspected upon a heart function evaluation. Biopsy specimens from the myocardium revealed transthyretin amyloidosis with the Ser50Arg mutation. Oral tafamidis therapy has inhibited the progression of neurological and cardiovascular symptoms this far...
September 25, 2017: Internal Medicine
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