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Keywords Hyponatemia

Hyponatemia

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JOURNAL ARTICLE

The influence of benzamil hydrochloride on the evolution of hyponatremic brain edema as assessed by in vivo MRI study in rats.

Roy Steier, Mihály Aradi, József Pál, Péter Bukovics, Gábor Perlaki, Gergely Orsi, József Janszky, Attila Schwarcz, Endre Sulyok, Tamás Dóczi

OBJECTIVE: The present study was undertaken to reveal the influence of intracerebroventricular (ICV) benzamil on the dynamics of brain water accumulation in hyponatremic rats. Parameters of brain water homeostasis were continuously monitored, using in vivo magnetic resonance imaging (MRI) methods. The results were compared with those obtained in a previous study by tissue desiccation. METHODS: A 3-T MRI instrument was applied to perform serial diffusion-weighted imaging to measure the apparent diffusion coefficient (ADC) and MR spectroscopy to determine water signal...

21445679

October 2011: Acta Neurochirurgica

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