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https://www.readbyqxmd.com/read/21445679/the-influence-of-benzamil-hydrochloride-on-the-evolution-of-hyponatremic-brain-edema-as-assessed-by-in-vivo-mri-study-in-rats
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Roy Steier, Mihály Aradi, József Pál, Péter Bukovics, Gábor Perlaki, Gergely Orsi, József Janszky, Attila Schwarcz, Endre Sulyok, Tamás Dóczi
OBJECTIVE: The present study was undertaken to reveal the influence of intracerebroventricular (ICV) benzamil on the dynamics of brain water accumulation in hyponatremic rats. Parameters of brain water homeostasis were continuously monitored, using in vivo magnetic resonance imaging (MRI) methods. The results were compared with those obtained in a previous study by tissue desiccation. METHODS: A 3-T MRI instrument was applied to perform serial diffusion-weighted imaging to measure the apparent diffusion coefficient (ADC) and MR spectroscopy to determine water signal...
October 2011: Acta Neurochirurgica
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