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https://www.readbyqxmd.com/read/28918435/infant-avoidance-training-alters-cellular-activation-patterns-in-prefronto-limbic-circuits-during-adult-avoidance-learning-ii-cellular-imaging-of-neurons-expressing-the-activity-regulated-cytoskeleton-associated-protein-arc-arg3-1
#1
Nicole Gröger, Anja Mannewitz, Jörg Bock, Susann Becker, Katja Guttmann, Gerd Poeggel, Katharina Braun
Positive and negative feedback learning is essential to optimize behavioral performance. We used the two-way active avoidance (TWA) task as an experimental paradigm for negative feedback learning with the aim to test the hypothesis that neuronal ensembles activate the activity-regulated cytoskeletal (Arc/Arg3.1) protein during different phases of avoidance learning and during retrieval. A variety of studies in humans and other animals revealed that the ability of aversive feedback learning emerges postnatally...
September 16, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28918392/cnvs-affecting-cancer-predisposing-genes-cpgs-detected-as-incidental-findings-in-routine-germline-diagnostic-chromosomal-microarray-cma-testing
#2
Josie Innes, Lisa Reali, Jill Clayton-Smith, Georgina Hall, Derek Hk Lim, George J Burghel, Kim French, Unzela Khan, Daniel Walker, Fiona Lalloo, D Gareth R Evans, Dominic McMullan, Eamonn R Maher, Emma R Woodward
BACKGROUND: Identification of CNVs through chromosomal microarray (CMA) testing is the first-line investigation in individuals with learning difficulties/congenital abnormalities. Although recognised that CMA testing may identify CNVs encompassing a cancer predisposition gene (CPG), limited information is available on the frequency and nature of such results. METHODS: We investigated CNV gains and losses affecting 39 CPGs in 3366 pilot index case individuals undergoing CMA testing, and then studied an extended cohort (n=10 454) for CNV losses at 105 CPGs and CNV gains at 9 proto-oncogenes implicated in inherited cancer susceptibility...
September 16, 2017: Journal of Medical Genetics
https://www.readbyqxmd.com/read/28917648/challenges-of-conducting-a-prospective-clinical-trial-for-older-patients-lessons-learned-from-ncctg-n0949-alliance
#3
Nadine J McCleary, Joleen Hubbard, Michelle R Mahoney, Jeffrey A Meyerhardt, Daniel Sargent, Alan Venook, Axel Grothey
OBJECTIVES: While the risk of developing colorectal cancer increases with age, there are limited prospective data regarding best treatment in the older adult population. We launched a phase III trial to evaluate difference in treatment outcome for older adults (aged ≥70years) with advanced colorectal cancer. Here we review the challenges faced and reasons for poor accrual to N0949. MATERIALS AND METHODS: We describe the conceptualization, development and limited results of N0949, a randomized phase III study of fluoropyrimidine/bevacizumab with or without oxaliplatin (mFOLFOX7 or XELOX) as first line chemotherapy for metastatic colorectal cancer...
September 13, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28917120/automated-arteriole-and-venule-classification-using-deep-learning-for-retinal-images-from-the-uk-biobank-cohort
#4
R A Welikala, P J Foster, P H Whincup, A R Rudnicka, C G Owen, D P Strachan, S A Barman
The morphometric characteristics of the retinal vasculature are associated with future risk of many systemic and vascular diseases. However, analysis of data from large population based studies is needed to help resolve uncertainties in some of these associations. This requires automated systems that extract quantitative measures of vessel morphology from large numbers of retinal images. Associations between retinal vessel morphology and disease precursors/outcomes may be similar or opposing for arterioles and venules...
September 8, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28916843/the-implicit-learning-of-metrical-and-non-metrical-rhythms-in-blind-and-sighted-adults
#5
Claudia Carrara-Augustenborg, Benjamin G Schultz
Forming temporal expectancies plays a crucial role in our survival as it allows us to identify the occurrence of temporal deviants that might signal potential dangers. The dynamic attending theory suggests that temporal expectancies are formed more readily for rhythms that imply a beat (i.e., metrical rhythms) compared to those that do not (i.e., nonmetrical rhythms). Moreover, metrical frameworks can be used to detect temporal deviants. Although several studies have demonstrated that congenital or early blindness correlates with modality-specific neural changes that reflect compensatory mechanisms, few have examined whether blind individuals show a learning advantage for auditory rhythms and whether learning can occur unintentionally and without awareness, that is, implicitly...
September 15, 2017: Psychological Research
https://www.readbyqxmd.com/read/28916842/how-interindividual-differences-in-brain-anatomy-shape-reading-accuracy
#6
Arnaud Cachia, Margot Roell, Jean-François Mangin, Zhong Yi Sun, Antoinette Jobert, Lucia Braga, Olivier Houde, Stanislas Dehaene, Grégoire Borst
The capacity to read develops throughout intensive academic learning and training. Several studies have investigated the impact of reading on the brain, and particularly how the anatomy of the brain changes with reading acquisition. In the present study, we investigated the converse issue, namely whether and how reading acquisition is constrained by the anatomy of the brain. Using multimodal MRI, we found that (a) the pattern (continuous or interrupted sulcus) of the posterior part of the left lateral occipito-temporal sulcus (OTS) hosting the visual word form area (VWFA) predicts reading skills in adults; that (b) this effect is modulated by the age of reading acquisition; and that (c) the length of the OTS sulcal interruption is associated with reading skills...
September 15, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28916631/experience-during-early-adulthood-shapes-the-learning-capacities-and-the-number-of-synaptic-boutons-in-the-mushroom-bodies-of-honey-bees-apis-mellifera
#7
Amélie Cabirol, Rufus Brooks, Claudia Groh, Andrew B Barron, Jean-Marc Devaud
The honey bee mushroom bodies (MBs) are brain centers required for specific learning tasks. Here, we show that environmental conditions experienced as young adults affect the maturation of MB neuropil and performance in a MB-dependent learning task. Specifically, olfactory reversal learning was selectively impaired following early exposure to an impoverished environment lacking some of the sensory and social interactions present in the hive. In parallel, the overall number of synaptic boutons increased within the MB olfactory neuropil, whose volume remained unaffected...
October 2017: Learning & Memory
https://www.readbyqxmd.com/read/28916626/contextual-fear-conditioning-in-zebrafish
#8
Justin W Kenney, Ian C Scott, Sheena A Josselyn, Paul W Frankland
Zebrafish are a genetically tractable vertebrate that hold considerable promise for elucidating the molecular basis of behavior. Although numerous recent advances have been made in the ability to precisely manipulate the zebrafish genome, much less is known about many aspects of learning and memory in adult fish. Here, we describe the development of a contextual fear conditioning paradigm using an electric shock as the aversive stimulus. We find that contextual fear conditioning is modulated by shock intensity, prevented by an established amnestic agent (MK-801), lasts at least 14 d, and exhibits extinction...
October 2017: Learning & Memory
https://www.readbyqxmd.com/read/28916500/early-life-stress-modulates-neural-networks-associated-with-habitual-use-of-reappraisal
#9
Elissa El Khawli, Yan Fan, Sabine Aust, Katharina Wirth, Luisa Bönke, Amie Stevense, Ana Herrera, Sophie Metz, Andrea Loayza, Malek Bajbouj, Simone Grimm
Recent evidence shows that early life stress (ELS) is associated with altered resting-state functional connectivity (RSFC) between amygdala and the prefrontal cortex, as well as with maladaptive emotion regulation strategies and negative mood. However, the relation between ELS and maladaptive emotion regulation is not deterministic. Adaptive emotion regulation strategies such as reappraisal can also ensue from experience and learning in adulthood and can prevent negative mood. The present study aims to investigate the joint influence of ELS, in particular early-life emotional abuse (EA), and habitual use of reappraisal on amygdala-centered RSFC and mood...
September 12, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28916019/the-basic-science-of-behavior-change-and-its-application-to-pediatric-providers
#10
REVIEW
Allison R Love, Peter S Jensen, Lisa Khan, Tiffany West Brandt, James Jaccard
Pediatric primary care providers (PPCPs) are increasingly expected to know how to assess, diagnose, and treat a wide range of mental health problems in children and adolescents. For many PPCPs, this means learning and performing new practice behaviors that were not taught in their residency training. Typical continuing education approaches to engage PPCPs in new practices have not yielded the desired changes in provider behavior. This article summarizes behavior change principles identified through basic behavior science, adult education, and communication research, and discusses their application to a patient-centered pediatric primary care mental health curriculum...
October 2017: Child and Adolescent Psychiatric Clinics of North America
https://www.readbyqxmd.com/read/28915987/interpreting-narratives-within-a-cross-national-interdisciplinary-study-a-case-study-of-a-collaborative-process
#11
Deborah L Tolman, Chunyan Yu, Kristin Mmari
PURPOSE: This article presents a case study of a collaborative process for the analysis of a young girl's narrative on becoming an adolescent in Shanghai. The purpose was to illuminate how interpretation of narratives can be strengthened with a diverse team of researchers. METHODS: Three different researchers, each representing a different discipline and lens for analyzing qualitative data, collaboratively analyzed and interpreted a 12-year-old girl's narrative from Shanghai as part of the Global Early Adolescent Study...
October 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28915986/exploration-of-gender-norms-and-socialization-among-early-adolescents-the-use-of-qualitative-methods-for-the-global-early-adolescent-study
#12
REVIEW
Kristin Mmari, Robert W Blum, Rebkha Atnafou, Elisa Chilet, Sara de Meyer, Omaima El-Gibaly, Sharmista Basu, Bamidele Bello, Beatrice Maina, Xiayun Zuo
PURPOSE: The Global Early Adolescent Study (GEAS) was launched in 2014 with the primary goal of understanding the factors in early adolescence that predispose young people to subsequent sexual risks, and conversely, those that promote healthy sexuality across different cultural contexts. The present article describes the methodology that was used for the first phase of GEAS, which consisted of conducting qualitative research to understand the gendered transitions into adolescence and the role that gender norms play within the key relationships of adolescents...
October 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28915861/informed-decision-making-with-and-for-people-with-dementia-efficacy-of-the-prodecide-education-program-for-legal-representatives-protocol-of-a-randomized-controlled-trial-prodecide-rct
#13
Julia Lühnen, Burkhard Haastert, Ingrid Mühlhauser, Tanja Richter
BACKGROUND: In Germany, the guardianship system provides adults who are no longer able to handle their own affairs a court-appointed legal representative, for support without restriction of legal capacity. Although these representatives only rarely are qualified in healthcare, they nevertheless play decisive roles in the decision-making processes for people with dementia. Previously, we developed an education program (PRODECIDE) to address this shortcoming and tested it for feasibility...
September 15, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28915298/the-effect-of-stimulus-variability-on-learning-and-generalization-of-reading-in-a-novel-script
#14
Jasmeen Adwan-Mansour, Tali Bitan
Purpose: The benefit of stimulus variability for generalization of acquired skills and knowledge has been shown in motor, perceptual, and language learning but has rarely been studied in reading. We studied the effect of variable training in a novel language on reading trained and untrained words. Method: Sixty typical adults received 2 sessions of training in reading an artificial script. Participants were assigned to 1 of 3 groups: a variable training group practicing a large set of 24 words, and 2 nonvariable training groups practicing a smaller set of 12 words, with twice the number of repetitions per word...
September 15, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/28914735/palliative-care-in-neuromuscular-diseases
#15
Marianne de Visser, David J Oliver
PURPOSE OF REVIEW: Palliative care is an approach that improves the quality of life of patients and their families facing the problem associated with life-threatening illness. Neuromuscular disorders (NMDs) are characterized by progressive muscle weakness, leading to pronounced and incapacitating physical disabilities. Most NMDs are not amenable to curative treatment and would thus qualify for palliative care. Amyotrophic lateral sclerosis is a relentlessly progressive disease, which leads to death about 2 years after onset due to respiratory muscle weakness...
September 13, 2017: Current Opinion in Neurology
https://www.readbyqxmd.com/read/28912440/the-generalization-of-auditory-accommodation-to-altered-spectral-cues
#16
Christopher J G Watson, Simon Carlile, Heather Kelly, Kapilesh Balachandar
The capacity of healthy adult listeners to accommodate to altered spectral cues to the source locations of broadband sounds has now been well documented. In recent years we have demonstrated that the degree and speed of accommodation are improved by using an integrated sensory-motor training protocol under anechoic conditions. Here we demonstrate that the learning which underpins the localization performance gains during the accommodation process using anechoic broadband training stimuli generalize to environmentally relevant scenarios...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28912012/the-effects-of-aerobic-exercise-on-depression-like-anxiety-like-and-cognition-like-behaviours-over-the-healthy-adult-lifespan-of-c57bl-6-mice
#17
Julie A Morgan, Gaurav Singhal, Frances Corrigan, Emily J Jaehne, Magdalene C Jawahar, Bernhard T Baune
Preclinical studies have demonstrated exercise improves various types of behaviours such as anxiety-like, depression-like, and cognition-like behaviours. However, these findings were largely conducted in studies utilising short-term exercise protocols, and the effects of lifetime exercise on these behaviours remain unknown. This study investigates the behavioural effects of lifetime exercise in normal healthy aging C57BL/6 mice over the adult lifespan. 12 week-old C57BL/6 mice were randomly assigned to voluntary wheel running or non-exercise (control) groups...
September 11, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28911966/fluoxetine-administration-during-adolescence-attenuates-cognitive-and-synaptic-deficits-in-adult-3%C3%A3-tgad-mice
#18
Dong-Sheng Sun, Li-Feng Gao, Li Jin, Hao Wu, Qun Wang, You Zhou, Shuhao Fan, Xia Jiang, Dan Ke, Hao Lei, Jian-Zhi Wang, Gong-Ping Liu
Fluoxetine (FLX) has broad neurobiological functions and neuroprotective effects; however, the preventive effects of FLX on cognitive impairments in Alzheimer's disease (AD) have not been reported. Here, we studied whether adolescent administration of fluoxetine can prevent memory deficits in AD transgenic mice that harbour PS1m146v, APPswe and TauP301L mutations (3 × TgAD). FLX was applied through peritoneal injection to the mice at postnatal day 35 (p35) for 15 consecutive days, and the effects of FLX were observed at 6-month...
September 11, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28911867/population-dynamics-of-neural-progenitor-cells-during-aging-in-the-cerebral-cortex
#19
Yuka Okada, Koji Ohira
Recent studies indicate that adult neurogenesis occurs in the cerebral cortex of rodents. Neural progenitor cells (NPCs) have been found in the adult cerebral cortex. These cells are expected to be regulated by various stimuli, including environmental enrichment, exercise, learning, and stress. However, it is unclear what stimuli can regulate cortical NPCs. In this study, we examined whether aging has an impact on population dynamics of NPCs in the murine cerebral cortex, using immunohistological staining for NPCs...
September 11, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28910656/test-retest-reliability-of-a-balance-testing-protocol-with-external-perturbations-in-young-healthy-adults
#20
Shawn M Robbins, Ryan M Caplan, Daniel I Aponte, Nancy St-Onge
External perturbations are utilized to challenge balance and mimic realistic balance threats in patient populations. The reliability of such protocols has not been established. The purpose was to examine test-retest reliability of balance testing with external perturbations. Healthy adults (n=34; mean age 23 years) underwent balance testing over two visits. Participants completed ten balance conditions in which the following parameters were combined: perturbation or non-perturbation, single or double leg, and eyes open or closed...
September 7, 2017: Gait & Posture
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