keyword
MENU ▼
Read by QxMD icon Read
search

cobalamin

keyword
https://www.readbyqxmd.com/read/29334459/development-of-charmm-compatible-force-field-parameters-for-cobalamin-and-related-cofactors-from-quantum-mechanical-calculations
#1
Anna Pavlova, Jerry M Parks, James C Gumbart
Corrinoid cofactors such as cobalamin are used by many enzymes and are essential for most living organisms. Therefore, there is broad interest in investigating cobalamin-protein interactions with molecular dynamics simulations. Previously developed parameters for cobalamins are based mainly on crystal structure data. Here, we report CHARMM-compatible force field parameters for several corrinoids developed from quantum mechanical calculations. We provide parameters for corrinoids in three oxidation states, Co3+, Co2+ and Co1+, and with various axial ligands...
January 15, 2018: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29313750/serum-retinol-folic-acid-and-copper-are-associated-with-sperm-abnormalities-in-men-with-obesity
#2
Berniza Calderón, Vital Hevia, Belén Vega-Piñero, Antonia Martín-Hidalgo, Helena Mendez-Del Sol, Héctor F Escobar-Morreale, José I Botella-Carretero
BACKGROUND AND OBJECTIVES: Micronutrients may influence the development and differentiation of sperm cells. The aim of this study was to assess the possible association of deficiencies in several vitamins and trace elements with sperm abnormalities in men with obesity. PARTICIPANTS AND METHODS: Thirty male patients with moderate to severe obesity and ten lean controls who gave written informed consent were included. Anthropometric parameters were recorded. Hormonal and lipid profiles were analyzed, as well as serum concentrations of zinc, copper, retinol, α-tocopherol, 25-hydroxyvitamin D, cobalamin, and folic acid...
January 9, 2018: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/29313679/a-pair-natural-orbitals-restricted-open-shell-configuration-interaction-pno-rocis-approach-for-calculating-x-ray-absorption-spectra-of-large-chemical-systems
#3
Dimitrios Maganas, Serena DeBeer, Frank Neese
In this work, the efficiency of first principles calculations of X-ray absorption spectra of large chemical systems is drastically improved. The approach is based on the previously developed restricted open shell configuration interaction singles (ROCIS) method and its parameterized version, based on a density functional theory (DFT) ground state determinant ROCIS/DFT. The combination of the ROCIS or DFT/ROCIS methods with the well-known machinery of the pair natural orbitals (PNOs) leads to the new PNO-ROCIS and PNO-ROCIS/DFT variants...
January 9, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29306994/association-between-maternal-and-infantile-markers-of-cobalamin-status-during-the-first-month-post-delivery
#4
Sümeyra Çoban, Ebru Yılmaz Keskin, Mahir İğde
OBJECTIVE: Exclusively breast-fed infants born to vitamin B12 (cobalamin, cbl)-deficient mothers can develop symptoms within a few months following delivery. The authors aimed to assess the relationship between maternal and infantile markers of cbl status. METHODS: In 240 full-term infants (age, 2-30 d) admitted to Samsun Maternity and Child Health Hospital and their mothers, complete blood count testing and serum cbl, folate and plasma total homocysteine (tHcy) measurements were performed...
January 6, 2018: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29298049/enhanced-solubilization-of-class-b-radical-s-adenosylmethionine-methylases-by-improved-cobalamin-uptake-in-escherichia-coli
#5
Nicholas Lanz, Anthony J Blaszczyk, Erin McCarthy, Bo Wang, Roy Wang, Brianne Jones, Squire J Booker
The methylation of unactivated carbon and phosphorus centers is a burgeoning area of biological chemistry, especially given that such reactions constitute key steps in the biosynthesis of numerous enzyme cofactors, antibiotics, and other natural products of clinical value. These kinetically challenging reactions are catalyzed exclusively by enzymes in the radical S-adenosylmethionine (SAM) superfamily and have been grouped into four classes: A, B, C, and D. Class B radical SAM (RS) methylases require a cobalamin cofactor in addition to the [4Fe-¬4S] cluster that is characteristic of RS enzymes...
January 3, 2018: Biochemistry
https://www.readbyqxmd.com/read/29222062/evolutionary-history-of-the-cobalamin-independent-methionine-synthase-gene-family-across-the-land-plants
#6
Hugo Vianna Silva Rody, Luiz Orlando de Oliveira
Plants are successful paleopolyploids. The wide diversity of land plants is driven strongly by their gene duplicates undergoing distinct evolutionary fates after duplication. We used genomic resources from 35 model plant species to unravel the evolutionary fate of gene copies (paralogs) of the cobalamin-independent methionine synthase (metE) gene family across the land plants. To explore genealogical relationships and characterize positive selection as a driving force in the evolution of metE paralogs within a single species, we carried out complementary analyses on genomic data of 32 genotypes of soybean...
December 6, 2017: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/29209773/effect-of-8-week-oral-supplementation-with-3-%C3%A2%C2%B5g-cyano-b12-or-hydroxo-b12-in-a-vitamin-b12-deficient-population
#7
Eva Greibe, Namita Mahalle, Vijayshri Bhide, Sergey Fedosov, Christian W Heegaard, Sadanand Naik, Ebba Nexo
PURPOSE: We compare the effect of 8-week oral supplementation with cyano-B12 (currently used in vitamin pills) and hydroxo-B12 (predominant form in the diet) in a population with nutritional vitamin B12 deficiency. METHODS: Fifty-one healthy Indian adults with baseline serum cobalamin < 200 pmol/L were supplied for 8 weeks with daily oral supplements of 3-µg cyano-B12 (n = 15), 3-µg hydroxo-B12 (n = 16), or a placebo (n = 20). Blood at baseline, and each following week, was examined for total cobalamin, holotranscobalamin, methylmalonic acid, and homocysteine...
December 5, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/29198615/reappraising-newborn-screening-for-cobalamin-c-disorder
#8
Vlad Tocan, Kazuhiro Ohkubo, Kanako Higashi, Naoko Toda, Kanako Kojima-Ishii, Kei Nishiyama, Masataka Ishimura, Hidetoshi Takada, Osamu Sakamoto, Fusako Sasaki, Kazuko Yoshimura, Shinichi Hirose, Shouichi Ohga
No abstract text is available yet for this article.
November 22, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/29189512/the-efficacy-of-oral-vitamin-b12-replacement-for-nutritional-vitamin-b12-deficiency
#9
Rabia G Sezer, Abdulkadir Bozaykut, Handan A Akoğlu, Gül N Özdemir
Standard treatment of vitamin B12 deficiency has not been well established in childhood, the ideal amount of supplemental vitamin B12 is not clear. Vitamin B12 deficiency is classically treated with intramuscular injections. In this study, we aimed to investigate the efficacy of oral therapy in children with vitamin B12 deficiency. Patients with serum cobalamin concentrations <300 pg/mL aged between 6 months to 18 years were included in this prospective study. Children were treated orally either with a combination of multivitamin tablet daily or vitamin B12 ampules...
November 17, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29178013/research-on-the-ability-of-propionic-acid-and-vitamin-b12-biosynthesis-by-propionibacterium-freudenreichii-strain-t82
#10
Kamil Piwowarek, Edyta Lipińska, Elżbieta Hać-Szymańczuk, Anna Bzducha-Wróbel, Alicja Synowiec
The purpose of this study was to determine the potential for biosynthesis of propionic acid and vitamin B12 by Propionibacterium freudenreichii T82 in a medium containing various sources of carbon (glucose, fructose, and saccharose). These sugars are present in apple pomaces, which are the waste from the production of apple juice. Using statistical analysis design of experiments (DoE), the results allowed us to determine which sugars (carbon sources) exert the most beneficial influence on the biosynthesis of propionic acid and cobalamin...
November 25, 2017: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/29172893/effect-of-age-sex-and-body-weight-on-the-serum-concentrations-of-cobalamin-and-folate-in-cats-consuming-a-consistent-diet
#11
Sarah A Hill, Nicholas J Cave, Sandra Forsyth
Objectives Multiple feline diseases involving the gastrointestinal tract, pancreas, liver and biliary tract are known to cause abnormal serum cobalamin and folate concentrations. Measuring the serum concentration of these vitamins can therefore be a helpful diagnostic tool. However, factors other than disease, in particular age, have also been suggested to have an effect on the serum concentration of cobalamin and folate. In previous studies, the dietary intake was not standardised, or even known, despite diet being the prinicpal source of both vitamins...
March 1, 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/29163729/prevalence-comorbidity-and-investigation-of-anemia-in-the-primary-care-office
#12
Shivani Jatin Gandhi, Iris Hagans, Karim Nathan, Krystal Hunter, Satyajeet Roy
Background: Anemia has a myriad of causes and its prevalence is growing. Anemia is associated with increased all-cause hospitalization and mortality in community-dwelling individuals above age 65 years. Our aim was to determine the prevalence and severity of anemia in adult patients in our primary care office and to determine the relationship between anemia and medical comorbidities. Methods: Electronic medical records of 499 adult patients in our suburban internal medicine office were reviewed who had had at least one hemoglobin value and did not undergo moderate to high-risk surgery in the preceding 30 days...
December 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29153845/identification-of-abc-transporters-acting-in-vitamin-b12-metabolism-in-caenorhabditis-elegans
#13
Megan K McDonald, Julie-Anne Fritz, Dongxin Jia, Deborah Scheuchner, Floyd F Snyder, Avalyn Stanislaus, Jared Curle, Liang Li, Sally P Stabler, Robert H Allen, Paul E Mains, Roy A Gravel
Vitamin B12 (cobalamin, Cbl) is a micronutrient essential to human health. Cbl is not utilized as is but must go through complex subcellular and metabolic processing to generate two cofactor forms: methyl-Cbl for methionine synthase, a cytosolic enzyme; and adenosyl-Cbl for methylmalonyl-CoA mutase, a mitochondrial enzyme. Some 10-12 human genes have been identified responsible for the intracellular conversion of Cbl to cofactor forms, including genes that code for ATP-binding cassette (ABC) transporters acting at the lysosomal and plasma membranes...
December 2017: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/29141978/cobalamin-status-from-pregnancy-to-early-childhood-lessons-from-global-experience
#14
REVIEW
Rima Obeid, Michelle Murphy, Pol Solé-Navais, Chittaranjan Yajnik
Low cobalamin intake and status during pregnancy or lactation have been linked to adverse maternal and perinatal health outcomes, whereas low cobalamin status during early childhood is associated with impaired development in children. Women who begin pregnancy with depleted stores (low or very low plasma cobalamin) will give birth to depleted infants who are likely to develop deficiency symptoms during the first few weeks or months postpartum. Newly ingested cobalamin during pregnancy and lactation (from diet or supplements) is transferred to the child and is not likely to correct cobalamin status in depleted women...
November 2017: Advances in Nutrition
https://www.readbyqxmd.com/read/29125158/photodissociation-of-ethylphenylcobalamin-antivitamin-b12
#15
Piotr Lodowski, Karolina Ciura, Megan J Toda, Maria Jaworska, Pawel M Kozlowski
Biologically active forms of cobalamins are crucial cofactors in biochemical reactions and these metabolites can be inhibited by their structurally similar analogues known as antivitamins B12. Phenylethynylcobalamin (PhEtyCbl) or 4-ethylphenylcobalamin (EtPhCbl) exemplify recently synthesized and structurally characterized antivitamins B12. Herein, DFT and TD-DFT studies of EtPhCbl are provided to explore its photochemical behavior, which may lead to design of arylcobalamins that can be used as therapeutic agents in light activated drug applications...
November 22, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29116760/relative-propensities-of-cytochrome-c-oxidase-and-cobalt-corrins-for-reaction-with-cyanide-and-oxygen-implications-for-amelioration-of-cyanide-toxicity
#16
Quan Yuan, Linda L Pearce, Jim Peterson
In aqueous media at neutral pH, the binding of two cyanide molecules per cobinamide can be described by two formation constants, Kf1 = 1.1 (±0.6) × 10(5) M(-1) and Kf2 = 8.5 (±0.1) × 10(4) M(-1), or an overall cyanide binding constant of ∼1 × 10(10) M(-2). In comparison, the cyanide binding constants for cobalamin and a fully oxidized form of cytochrome c oxidase, each binding a single cyanide anion, were found to be 7.9 (±0.5) × 10(4) M(-1) and 1.6 (±0.2) × 10(7) M(-1), respectively. An examination of the cyanide-binding properties of cobinamide at neutral pH by stopped-flow spectrophotometry revealed two kinetic phases, rapid and slow, with apparent second-order rate constants of 3...
November 21, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/29114403/transcriptomic-analysis-of-aerobic-respiratory-and-anaerobic-photosynthetic-states-in-rhodobacter-capsulatus-and-their-modulation-by-global-redox-regulators-rega-fnrl-and-crtj
#17
Joseph E Kumka, Heidi Schindel, Mingxu Fang, Sebastien Zappa, Carl E Bauer
Anoxygenicphotosynthetic prokaryotes have simplified photosystems that represent ancient lineages that predate the more complex oxygen evolving photosystems present in cyanobacteria and chloroplasts. These organisms thrive under illuminated anaerobic photosynthetic conditions, but also have the ability to grow under dark aerobic respiratory conditions. This study provides a detailed snapshot of transcription ground states of both dark aerobic and anaerobic photosynthetic growth modes in the purple photosynthetic bacterium Rhodobactercapsulatus...
September 2017: Microbial Genomics
https://www.readbyqxmd.com/read/29104950/-89-zr-cobalamin-pet-tracer-synthesis-cellular-uptake-and-use-for-tumor-imaging
#18
Akhila N W Kuda-Wedagedara, Jayme L Workinger, Ebba Nexo, Robert P Doyle, Nerissa Viola-Villegas
Vitamin B12, or cobalamin (Cbl), is an essential nutrient. Acquisition, transport, and cellular internalization of Cbl are dependent on specific binding proteins and associated receptors. The circulating transport protein transcobalamin (TC) promotes cellular uptake via binding to specific receptors such as CD320, a receptor upregulated in several cancer cell lines. In this study, we report the successful synthesis of (89)Zirconium-labeled Cbl that was derivatized with desferrioxamine ((89)Zr-Cbl). We document the purity of the tracer and its binding to TC compared with that of unmodified cyano-Cbl (CN-Cbl)...
October 31, 2017: ACS Omega
https://www.readbyqxmd.com/read/29099902/correlation-between-the-fceai-and-diagnostic-parameters-in-chronic-enteropathies-in-147-cats-2006-2012
#19
Stefanie Mitze, Katharina Moser, Erik Teske, Wolf V Bomhard, Christian Stockhaus
OBJECTIVE: The Feline Chronic Enteropathy Activity Index (FCEAI) has been established as a quantitative index for disease activity in chronic enteropathies in cats. A definite diagnosis is aimed at histology with initial exclusion of extraintestinal causes by laboratory examinations, diagnostic imaging and endoscopy. The study aimed to examine diagnostic parameters and FCEAI in chronic gastroenteropathies. MATERIALS AND METHODS: A retrospective case review of 147 cats with chronic enteropathies was performed...
November 3, 2017: Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
https://www.readbyqxmd.com/read/29098535/skin-lesions-in-a-patient-with-cobalamin-c-disease-in-poor-metabolic-control
#20
Pankaj Prasun, Cristel Chapel-Crespo, Amy Williamson, Paul Chu, Kimihiko Oishi, George Diaz
No abstract text is available yet for this article.
November 2, 2017: Journal of Inherited Metabolic Disease
keyword
keyword
5853
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"