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https://www.readbyqxmd.com/read/29141978/cobalamin-status-from-pregnancy-to-early-childhood-lessons-from-global-experience
#1
REVIEW
Rima Obeid, Michelle Murphy, Pol Solé-Navais, Chittaranjan Yajnik
Low cobalamin intake and status during pregnancy or lactation have been linked to adverse maternal and perinatal health outcomes, whereas low cobalamin status during early childhood is associated with impaired development in children. Women who begin pregnancy with depleted stores (low or very low plasma cobalamin) will give birth to depleted infants who are likely to develop deficiency symptoms during the first few weeks or months postpartum. Newly ingested cobalamin during pregnancy and lactation (from diet or supplements) is transferred to the child and is not likely to correct cobalamin status in depleted women...
November 2017: Advances in Nutrition
https://www.readbyqxmd.com/read/29125158/photodissociation-of-ethylphenylcobalamin-antivitamin-b12
#2
Piotr Lodowski, Karolina Ciura, Megan J Toda, Maria Jaworska, Pawel M Kozlowski
Biologically active forms of cobalamins are crucial cofactors in biochemical reactions and these metabolites can be inhibited by their structurally similar analogues known as antivitamins B12. Phenylethynylcobalamin (PhEtyCbl) or 4-ethylphenylcobalamin (EtPhCbl) exemplify recently synthesized and structurally characterized antivitamins B12. Herein, DFT and TD-DFT studies of EtPhCbl are provided to explore its photochemical behavior, which may lead to design of arylcobalamins that can be used as therapeutic agents in light activated drug applications...
November 10, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29116760/the-relative-propensities-of-cytochrome-c-oxidase-and-cobalt-corrins-for-reaction-with-cyanide-and-oxygen-implications-for-amelioration-of-cyanide-toxicity
#3
Quan Yuan, Linda Lorraine Pearce, Jim Peterson
In aqueous media at neutral pH, the binding of two cyanide molecules per cobinamide can be described by two formation constants, Kf1 = 1.1 (±0.6) × 105 M-1 and Kf2 = 8.5 (±0.1) × 104 M-1, or an overall cyanide binding constant of ~1 × 1010 M-2. In comparison, the cyanide binding constants for cobalamin and a fully oxidized form of cytochrome c oxidase, each binding a single cyanide anion, were found to be 7.9 (±0.5) × 104 M-1 and 1.6 (±0.2) × 107 M-1, respectively. An examination of the cyanide-binding properties of cobinamide at neutral pH by stopped-flow spectrophotometry revealed two kinetic phases, rapid and slow, with apparent second-order rate constants of 3...
November 8, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/29114403/transcriptomic-analysis-of-aerobic-respiratory-and-anaerobic-photosynthetic-states-in-rhodobacter-capsulatus-and-their-modulation-by-global-redox-regulators-rega-fnrl-and-crtj
#4
Joseph E Kumka, Heidi Schindel, Mingxu Fang, Sebastien Zappa, Carl E Bauer
Anoxygenicphotosynthetic prokaryotes have simplified photosystems that represent ancient lineages that predate the more complex oxygen evolving photosystems present in cyanobacteria and chloroplasts. These organisms thrive under illuminated anaerobic photosynthetic conditions, but also have the ability to grow under dark aerobic respiratory conditions. This study provides a detailed snapshot of transcription ground states of both dark aerobic and anaerobic photosynthetic growth modes in the purple photosynthetic bacterium Rhodobactercapsulatus...
September 2017: Microbial Genomics
https://www.readbyqxmd.com/read/29104950/-89-zr-cobalamin-pet-tracer-synthesis-cellular-uptake-and-use-for-tumor-imaging
#5
Akhila N W Kuda-Wedagedara, Jayme L Workinger, Ebba Nexo, Robert P Doyle, Nerissa Viola-Villegas
Vitamin B12, or cobalamin (Cbl), is an essential nutrient. Acquisition, transport, and cellular internalization of Cbl are dependent on specific binding proteins and associated receptors. The circulating transport protein transcobalamin (TC) promotes cellular uptake via binding to specific receptors such as CD320, a receptor upregulated in several cancer cell lines. In this study, we report the successful synthesis of (89)Zirconium-labeled Cbl that was derivatized with desferrioxamine ((89)Zr-Cbl). We document the purity of the tracer and its binding to TC compared with that of unmodified cyano-Cbl (CN-Cbl)...
October 31, 2017: ACS Omega
https://www.readbyqxmd.com/read/29099902/correlation-between-the-fceai-and-diagnostic-parameters-in-chronic-enteropathies-in-147-cats-2006-2012
#6
Stefanie Mitze, Katharina Moser, Erik Teske, Wolf V Bomhard, Christian Stockhaus
OBJECTIVE: The Feline Chronic Enteropathy Activity Index (FCEAI) has been established as a quantitative index for disease activity in chronic enteropathies in cats. A definite diagnosis is aimed at histology with initial exclusion of extraintestinal causes by laboratory examinations, diagnostic imaging and endoscopy. The study aimed to examine diagnostic parameters and FCEAI in chronic gastroenteropathies. MATERIALS AND METHODS: A retrospective case review of 147 cats with chronic enteropathies was performed...
November 3, 2017: Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
https://www.readbyqxmd.com/read/29098535/skin-lesions-in-a-patient-with-cobalamin-c-disease-in-poor-metabolic-control
#7
Pankaj Prasun, Cristel Chapel-Crespo, Amy Williamson, Paul Chu, Kimihiko Oishi, George Diaz
No abstract text is available yet for this article.
November 2, 2017: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/29098480/metagenomic-analysis-reveals-potential-interactions-in-an-artificial-coculture
#8
Minglei Ren, Guiying Zhang, Zi Ye, Zhixian Qiao, Meili Xie, Yan Lin, Tao Li, Jindong Zhao
Disentangling the interactions between cyanobacteria and associated bacterial community is important for understanding the mechanisms that mediate the formation of cyanobacterial blooms in freshwater ecosystems. Despite the fact that a metagenomic approach enables researchers to profile the structure of microbial communities associated with cyanobacteria, reconstructing genome sequences for all members remains inefficient, due to the inherent enormous microbial diversity. Here, we have established a stable coculture system under high salinity, originally from a mixture of an axenic cyanobacterium Synechococcus sp...
November 2, 2017: AMB Express
https://www.readbyqxmd.com/read/29091410/reaction-catalyzed-by-genk-a-cobalamin-dependent-radical-s-adenosyl-l-methionine-methyltransferase-in-the-biosynthetic-pathway-of-gentamicin-proceeds-with-retention-of-configuration
#9
Hak Joong Kim, Yung-Nan Liu, Reid M McCarty, Hung-Wen Liu
Many cobalamin (Cbl)-dependent radical S-adenosyl-l-methionine (SAM) methyltransferases have been identified through sequence alignment and/or genetic analysis; however, few have been studied in vitro. GenK is one such enzyme that catalyzes methylation of the 6'-carbon of gentamicin X2 (GenX2) to produce G418 during the biosynthesis of gentamicins. Reported herein, several alternative substrates and fluorinated substrate analogs were prepared to investigate the mechanism of methyl transfer from Cbl to the substrate as well as the substrate specificity of GenK...
November 15, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29083435/dairy-intakes-in-older-irish-adults-and-effects-on-vitamin-micronutrient-status-data-from-the-tuda-study
#10
E Laird, M C Casey, M Ward, L Hoey, C F Hughes, K McCarroll, C Cunningham, J J Strain, H McNulty, A M Molloy
BACKGROUND: Consumption of dairy products has been associated with positive health outcomes including a lower risk of hypertension, improved bone health and a reduction in the risk of type 2 diabetes. The suggested dairy intake for health in older adults is three servings per day but recent analysis of the NHANES data for older adults reported 98% were not meeting these recommendations. No studies have investigated the consequences of such declines in the dairy intakes of Irish older adults and the subsequent effects on vitamin micronutrient status...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29075065/relationship-between-the-levels-of-holotranscobalamin-and-vitamin-b12-in-children
#11
Ikbal Ok Bozkaya, Nese Yarali, Murat Kizilgün, Secil Ozkan, Bahattin Tunc
The purpose of this study was to evaluate the relationship between the plasma holoTC and serum vitamin B12 in children and to identify a cutoff cobalamin values according to holoTC. One hundred and fifty-five children were enrolled into the study. All children were evaluated for hemoglobin, vitamin B12, folate, ferritin and holoTC levels. Children were grouped as with low vitamin B12 level (≤200 pg/mL, group I) and normal vitamin B12 (>200 pg/mL, group II). Serum vitamin B12, and holoTC levels were performed in each patient in the study...
December 2017: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/29074162/insights-into-the-role-of-methionine-synthase-in-the-universal-13-c-depletion-in-o-and-n-methyl-groups-of-natural-products
#12
Katarzyna M Romek, Agnieszka Krzemińska, Gérald S Remaud, Maxime Julien, Piotr Paneth, Richard J Robins
Many O-methyl and N-methyl groups in natural products are depleted in (13)C relative to the rest of the molecule. These methyl groups are derived from the C-1 tetrahydrofolate pool via l-methionine, the principle donor of methyl units. Depletion could occur at a number of steps in the pathway. We have tested the hypothesis that methionine biosynthesis is implicated in this depletion by using a combined experimental and theoretical approach. By using isotope ratio monitoring (13)C NMR spectrometry to measure the position-specific distribution of (13)C within l-methionine of natural origin, it is shown that the S-methyl group is depleted in (13)C by ∼20‰ relative to the other positions in the molecule...
October 23, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29069827/the-effect-of-mvk-mmab-variants-their-haplotypes-and-g%C3%A3-e-interactions-on-serum-lipid-levels-and-the-risk-of-coronary-heart-disease-and-ischemic-stroke
#13
Liu Miao, Rui-Xing Yin, Feng Huang, Wu-Xian Chen, Xiao-Li Cao, Jin-Zhen Wu
AIM: This study aimed to detect the association of the mevalonate kinase (MVK) and methylmalonic aciduria (cobalamin deficiency) cblB type (MMAB) gene variants, their haplotypes, and gene-environment (G×E) interactions on serum lipid levels and the risk of coronary heart disease (CHD) and ischemic stroke (IS) in a Chinese Han population. METHODS: Genotyping of the rs3759387, rs7134594, rs877710 and rs9593 SNPs in 846 CHD and 869 IS patients and 847 healthy controls was performed by PCR-RFLP and Sanger sequencing...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29068997/atypical-hemolytic-uremic-syndrome-induced-by-cblc-subtype-of-methylmalonic-academia-a-case-report-and-literature-review
#14
REVIEW
Minguang Chen, Jieqiu Zhuang, JianHuan Yang, Dexuan Wang, Qing Yang
RATIONALE: Methylmalonic acidemia (MMA) is a common organic acidemia, mainly due to methylmalonyl-CoA mutase (MCM) or its coenzyme cobalamin (VitB12) metabolic disorders. Cobalamin C (CblC) type is the most frequent inborn error of cobalamin metabolism; it can develop symptoms in childhood and often combine multisystem damage, which leads to methylmalonic acid, propionic acid, methyl citrate, and other metabolites abnormal accumulation, causing nerve, liver, kidney, bone marrow, and other organ damage...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29064580/preparation-and-characterization-of-a-novel-hydrogel-based-on-auricularia-polytricha-%C3%AE-glucan-and-its-bio-release-property-for-vitamin-b12-delivery
#15
Kai Zhu, Xiaoyuan Chen, Da Yu, Yue He, Guanglei Song
BACKGROUND: This study investigates a novel hydrogel synthesis method and its bio-release property. This hydrogel with three-dimensional network structure based on Auricularia polytricha β-glucan was characterized by means of Fourier transform infrared spectroscopy (FTIR), (1) H-NMR and scanning electron microscope (SEM). Vitamin B12 (VB12 , cobalamin) as a hydrophilic functional food component was entrapped into these hydrogels, in vitro release profile of VB12 was established in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF)...
October 24, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29061498/effect-of-a-red-blood-cell-transfusion-on-biological-markers-used-to-determine-the-cause-of-anemia-a-prospective-study
#16
Antoine Froissart, Benjamin Rossi, Brigitte Ranque, Irène Jarrin, Jean-François Bergmann, Sébastien Beaune, Sandrine Dautheville, Nicole Breau, Agnès Dauvergne, Lauréline Deluche, Tiphaine Robert, Nathalie Gault, Carine Roy, Virginie Zarrouk, Olivier Steichen, Bruno Fantin
BACKGROUND: Blood test results required for the evaluation of anemia are considered difficult to interpret after red blood cell transfusion. However, this hypothesis is neither supported by a strong physiological rationale nor is it evidence based. METHODS: We conducted a prospective multicenter study to compare the values of key assays before and after a course of red blood cell transfusion in the emergency or internal medicine units in four university hospitals...
October 20, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/29053148/stress-response-of-a-marine-ammonia-oxidizing-archaeon-informs-physiological-status-of-environmental-populations
#17
Wei Qin, Shady A Amin, Rachel A Lundeen, Katherine R Heal, Willm Martens-Habbena, Serdar Turkarslan, Hidetoshi Urakawa, Kyle C Costa, Erik L Hendrickson, Tony Wang, David Ac Beck, Sonia M Tiquia-Arashiro, Fred Taub, Andrew D Holmes, Neeraja Vajrala, Paul M Berube, Todd M Lowe, James W Moffett, Allan H Devol, Nitin S Baliga, Daniel J Arp, Luis A Sayavedra-Soto, Murray Hackett, E Virginia Armbrust, Anitra E Ingalls, David A Stahl
High representation by ammonia-oxidizing archaea (AOA) in marine systems is consistent with their high affinity for ammonia, efficient carbon fixation, and copper (Cu)-centric respiratory system. However, little is known about their response to nutrient stress. We therefore used global transcriptional and proteomic analyses to characterize the response of a model AOA, Nitrosopumilus maritimus SCM1, to ammonia starvation, Cu limitation and Cu excess. Most predicted protein-coding genes were transcribed in exponentially growing cells, and of ~74% detected in the proteome, ~6% were modified by N-terminal acetylation...
October 20, 2017: ISME Journal
https://www.readbyqxmd.com/read/29050287/association-between-the-mvk-and-mmab-polymorphisms-and-serum-lipid-levels
#18
Liu Miao, Rui-Xing Yin, Shang-Ling Pan, Shuo Yang, De-Zhai Yang, Wei-Xiong Lin
Maonan ethnic group is a relatively conservative and isolated minority in China. Little is known about the association of the mevalonate kinase (MVK), methylmalonic aciduria (cobalamin deficiency) cblB type (MMAB) single nucleotide polymorphisms (SNPs) and serum lipid levels. This study aimed to determine the association between four SNPs in the MVK/MMAB and serum lipid levels. Genotyping of the rs3759387, rs877710, rs7134594 and rs9593 SNPs was performed in 1264 Maonan subjects and 1251 Han participants. Allele and genotype frequencies of the selected SNPs were different between the two populations (P < 0...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29046740/draft-genome-sequence-and-characterization-of-commensal-escherichia-coli-strain-bg1-isolated-from-bovine-gastro-intestinal-tract
#19
Audrey Segura, Pauline Auffret, Christophe Klopp, Yolande Bertin, Evelyne Forano
Escherichia coli is the most abundant facultative anaerobic bacteria in the gastro-intestinal tract of mammals but can be responsible for intestinal infection due to acquisition of virulence factors. Genomes of pathogenic E. coli strains are widely described whereas those of bovine commensal E. coli strains are very scarce. Here, we report the genome sequence, annotation, and features of the commensal E. coli BG1 isolated from the gastro-intestinal tract of cattle. Whole genome sequencing analysis showed that BG1 has a chromosome of 4,782,107 bp coding for 4465 proteins and 97 RNAs...
2017: Standards in Genomic Sciences
https://www.readbyqxmd.com/read/29043603/epigenetic-modifications-of-gene-expression-by-lifestyle-and-environment
#20
REVIEW
Qudeer Ahmed Abdul, Byung Pal Yu, Hae Young Chung, Hyun Ah Jung, Jae Sue Choi
Epigenetics oftenly described as the heritable changes in gene expression independent of changes in DNA sequence. Various environmental factors such as nutrition-dietary components, lifestyle, exercise, physical activity, toxins, and other contributing factors remodel the genome either in a constructive or detrimental way. Since epigenetic changes are reversible and nutrition is one of the many epigenetic regulators that modify gene expression without changing the DNA sequence, dietary nutrients and bioactive food components contribute to epigenetic phenomena either by directly suppressing DNA methylation or histone catalyzing enzymes or by changing the availability of substrates required for enzymatic reactions...
October 17, 2017: Archives of Pharmacal Research
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