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https://www.readbyqxmd.com/read/27930821/assessment-of-asymmetrical-dimethylarginine-metabolism-in-patients-with-critical-illness
#1
Rawia A Ghashut, Scott Blackwell, Sylvia Ryan, Laura Willox, Donald C McMillan, John Kinsella, Dinesh Talwar
BACKGROUND: Critically ill patients experience metabolic disorders including hypercatabolic state and hyperglycaemia and these are associated with poor outcome. Hyperglycaemia and asymmetric dimethylarginine (ADMA) are reported to have significant influences on endothelial dysfunction. The aim of the present study was to examine the relationship between plasma asymmetric dimethylarginine (ADMA) and related arginine metabolism in patients with critical illness. MATERIALS AND METHODS: Two venous blood samples (EDTA) (104 patients), on admission and follow up sample in the last day in ICU (died or discharge sample median 7, IQR 6-8, range 5-15)...
December 8, 2016: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27918455/targeting-on-asymmetric-dimethylarginine-related-nitric-oxide-reactive-oxygen-species-imbalance-to-reprogram-the-development-of-hypertension
#2
REVIEW
You-Lin Tain, Chien-Ning Hsu
Adult-onset diseases, including hypertension, can originate from early life, known as the developmental origins of health and disease (DOHaD). Because the developing kidney is vulnerable to early-life insults, renal programming is considered key in the developmental programming of hypertension. Asymmetric dimethylarginine (ADMA), an endogenous nitric oxide (NO) synthase inhibitor, can regulate the NO-reactive oxygen species (ROS) balance, and is involved in the development of hypertension. Reprogramming interventions aimed at NO-ROS balance can be protective in both genetic and developmentally programmed hypertension...
December 2, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27914500/effect-of-l-arginine-asymmetric-dimethylarginine-and-symmetric-dimethylarginine-on-ischemic-heart-disease-risk-a-mendelian-randomization-study
#3
Shiu Lun Au Yeung, Shi Lin Lin, Hung San Hugh Simon Lam, Catherine Mary Schooling
BACKGROUND: l-arginine is a commonly consumed dietary conditional essential amino acid found in food items and supplements, which is closely related to asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA). l-arginine is thought to increase nitric oxide and be cardioprotective, whereas ADMA and SDMA may inhibit nitric oxide synthesis and increase cardiovascular disease risk. Unexpectedly, l-arginine increased mortality in a small trial. To clarify the effects of these potential targets of intervention, we assessed the risk of ischemic heart disease (IHD) by genetically determined l-arginine, ADMA, and SDMA...
December 2016: American Heart Journal
https://www.readbyqxmd.com/read/27909412/modeling-disease-progression-angiotensin-ii-indirectly-inhibits-nitric-oxide-production-via-adma-accumulation-in-spontaneously-hypertensive-rats
#4
Haidong Wang, Hao Jiang, Haochen Liu, Xue Zhang, Guimei Ran, Hua He, Xiaoquan Liu
Nitric oxide (NO) production impairment is involved in the onset and development of hypertension. Although NO production impairment in spontaneously hypertensive rat (SHR) has been reported in a variety of researches, the time course of this progressive procedure, as well as its relationship with asymmetric dimethylarginine (ADMA) and angiotensin II (Ang II), has not been quantified. The aim of this research is to establish a mechanism-based disease progression model to assess Ang II and ADMA's inhibition of NO production in SHR's disease progression with/without ramipril's intervention...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27886426/retraction-statement-high-volumetric-performance-aligned-nano-porous-microwave-exfoliated-graphite-oxide-based-electrochemical-capacitors-and-aligned-nano-porous-microwave-exfoliated-graphite-oxide-ionic-actuators-with-high-strain-and-elastic-energy-density
#5
(no author information available yet)
These articles first published on 15 August 2013 and 21 August 2013 on the Wiley Online Library have been retracted at the request of the Research Integrity Officer (RIO) of The Pennsylvania State University, in agreement with the corresponding authors, the journal's Editor-in-Chief, and Wiley-VCH Verlag GmbH & Co. KGaA, because portions of the reported results cannot be considered reliable or reproducible. Following an investigation by the RIO of The Pennsylvania State University, it was found that the data in Figure 2a,b and Figure S1a,b (Supporting Information) of the article with DOI: 10...
November 2016: Advanced Materials
https://www.readbyqxmd.com/read/27885576/asymmetric-dimethylarginine-and-hepatic-encephalopathy-cause-effect-or-association
#6
Anna Czarnecka, Krzysztof Milewski, Magdalena Zielińska
The methylated derivative of L-arginine, asymmetric dimethylarginine (ADMA) is synthesized in different mammalian tissues including the brain. ADMA acts as an endogenous, nonselective, competitive inhibitor of all three isoforms of nitric oxide synthase (NOS) and may limit L-arginine supply from the plasma to the enzyme via reducing its transport by cationic amino acid transporters. Hepatic encephalopathy (HE) is a relatively frequently diagnosed complex neuropsychiatric syndrome associated with acute or chronic liver failure, characterized by symptoms linked with impaired brain function leading to neurological disabilities...
November 25, 2016: Neurochemical Research
https://www.readbyqxmd.com/read/27884754/increased-serum-concentrations-of-asymmetric-dimethylarginine-adma-in-patients-with-early-onset-coronary-artery-disease
#7
Chao Xuan, Zhen-Fang Liu, Qing Wang, Fen-Fen Guo, Xiao Zhang, Guo-Wei He, Li-Min Lun
BACKGROUND: Asymmetric dimethylarginine (ADMA) has been associated with an increased risk of cardiovascular disease. We investigated the role of serum ADMA concentrations in early-onset coronary artery disease (EOCAD). METHODS: Candidates for coronary artery angiography (age<50y for men and <55y for women) who met the inclusion criteria were enrolled in this study. Serum concentrations of ADMA were determined using ELISA. Severity of coronary atherosclerosis was estimated by number of diseased vessels...
November 22, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/27865966/febuxostat-attenuates-paroxysmal-atrial-fibrillation-induced-regional-endothelial-dysfunction
#8
YanGuang Li, FuKun Chen, Long Deng, Kun Lin, Xiangmin Shi, Shan Zhaoliang, YuTang Wang
BACKGROUND: Paroxysmal atrial fibrillation (PAF) can increase thrombogenesis risk, especially in the left atrium (LA). The exact mechanism is still unclear. OBJECTIVE: We assessed the effects of PAF on endothelial function, and investigated if febuxostat (FX) can attenuate endothelial dysfunction by inhibition of xanthine oxidase (XO). MATERIALS AND METHODS: Eighteen male New Zealand white rabbits were divided randomly into sham-operated (S), PAF (P) or FX+pacing (FP) groups...
November 11, 2016: Thrombosis Research
https://www.readbyqxmd.com/read/27858190/nitro-oleic-acid-prevents-hypoxia-and-asymmetric-dimethylarginine-induced-pulmonary-endothelial-dysfunction
#9
Adolf Koudelka, Gabriela Ambrozova, Anna Klinke, Tana Fidlerova, Hana Martiskova, Radek Kuchta, Tanja K Rudolph, Jaroslav Kadlec, Zdenka Kuchtova, Steven R Woodcock, Bruce A Freeman, Lukas Kubala, Michaela Pekarova
RATIONALE: Pulmonary hypertension (PH) represents a serious health complication accompanied with hypoxic conditions, elevated levels of asymmetric dimethylarginine (ADMA), and overall dysfunction of pulmonary vascular endothelium. Since the prevention strategies for treatment of PH remain largely unknown, our study aimed to explore the effect of nitro-oleic acid (OA-NO2), an exemplary nitro-fatty acid (NO2-FA), in human pulmonary artery endothelial cells (HPAEC) under the influence of hypoxia or ADMA...
November 17, 2016: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/27834186/twelve-week-conjugated-linoleic-acid-supplementation-has-no-effects-on-the-selected-markers-of-atherosclerosis-in-obese-and-overweight-women
#10
Monika Dus-Zuchowska, Edyta Madry, Patrycja Krzyzanowska, Paweł Bogdanski, Jaroslaw Walkowiak
BACKGROUND: The antiatherogenic effect of conjugated linoleic acid (CLA) has been demonstrated in animal models. Although there are plenty of in vitro studies that suggest the profitable properties of CLA, the results in humans remain inconsistent. OBJECTIVE: In this study, we assessed the impact of CLA supplementation on the levels of atherosclerosis markers - high-sensitivity C-reactive protein (hs-CRP) and asymmetrical dimethylarginine (ADMA). DESIGN: Seventy-four adult female subjects with body mass index ≥25 kg/m(2) were enrolled in the double-blind, placebo-controlled nutritional intervention...
2016: Food & Nutrition Research
https://www.readbyqxmd.com/read/27831642/plasma-pentraxin-3-is-associated-with-endothelial-dysfunction-in-non-alcoholic-fatty-liver-disease
#11
H Gurel, H Genc, G Celebi, E Sertoglu, A F Cicek, H Kayadibi, C N Ercin, T Dogru
OBJECTIVE: Pentraxin-3 (PTX-3) is an acute-phase protein belonging to the PTX family. It has been reported that PTX-3 is significantly associated with obesity, metabolic syndrome, and cardiovascular diseases (CVD). Non-alcoholic fatty liver disease (NAFLD) is strongly associated with atherosclerosis and CVD. In this study, we aimed to investigate the relationship of PTX-3 with circulating markers of endothelial dysfunction and atherosclerosis in patients with NAFLD. PATIENTS AND METHODS: Seventy patients with biopsy-proven NAFLD and seventy healthy controls were enrolled in the study...
October 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27828654/nailfold-capillaroscopy-in-leprosy
#12
Adma Silva de Lima, Vanessa Irusta Dal Pizzol, Scheila Fritsch, Gabriela Poglia Fonseca, Fabiane Andrade Mulinari-Brenner, Carolina de Souza Muller, Vanessa Cristhine Dalombo Ottoboni
Due to mounting evidences of interaction between Hansen's bacilli with endothelial cells and the paucity of studies addressing the presence of nailfold capillaroscopic alterations in patients with Hansen's disease, a study was carried out in order to verify the presence of capillaroscopic alterations in patients with leprosy in its various forms and its correlation with clinical parameters. Ten patients were evaluated at a specialized university service. Sixty percent of those had some capillaroscopic change, such as micro-hemorrhages, ectatic, bushy and corkscrew capillaries...
September 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/27812151/asymmetric-and-symmetric-dimethylarginine-as-risk-markers-for-total-mortality-and-cardiovascular-outcomes-a-systematic-review-and-meta-analysis-of-prospective-studies
#13
Sabrina Schlesinger, Svenja R Sonntag, Wolfgang Lieb, Renke Maas
BACKGROUND: A growing number of studies linked elevated concentrations of circulating asymmetric (ADMA) and symmetric (SDMA) dimethylarginine to mortality and cardiovascular disease (CVD) events. To summarize the evidence, we conducted a systematic review and quantified associations of ADMA and SDMA with the risks of all-cause mortality and incident CVD in meta-analyses accounting for different populations and methodological approaches of the studies. METHODS: Relevant studies were identified in PubMed until February 2015...
2016: PloS One
https://www.readbyqxmd.com/read/27809903/effect-of-trelagliptin-on-vascular-endothelial-functions-and-serum-adiponectin-level-in-patients-with-type-2-diabetes-a-preliminary-single-arm-prospective-pilot-study
#14
Satoshi Ida, Kazuya Murata, Katunori Betou, Chiaki Kobayashi, Yuki Ishihara, Kanako Imataka, Akihiro Uchida, Kou Monguchi, Ryutaro Kaneko, Ryoko Fujiwara, Hiroka Takahashi
BACKGROUND: Trelagliptin, an oral DPP-4 inhibitor, which is administered once per week and characterized by a long half-life in blood. The effects of trelagliptin on vascular endothelial functions have not been clarified to date. The objective of the present study was to examine the effects of trelagliptin on vascular endothelial functions in patients with type 2 diabetes mellitus (DM) using flow-mediated dilatation (FMD), adiponectin, and asymmetric dimethylarginine (ADMA) as evaluation indicators...
November 4, 2016: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/27802898/oxymatrine-attenuated-isoproterenol-induced-heart-failure-in-rats-via-regulation-of-cox-2-pgi2-pathway
#15
Ru Zhou, Qingbin Xu, Yehua Xu, Aiqin Xiong, Yang Wang, Ping Ma
Oxymatrine (OMT) is an active constituent of traditional Chinese herb Sophora japonica Ait which has been shown to exert potent anti-inflammatory,anti-oxidant and anti-fibrosis properties. Our previous studies have demonstrated that OMT has protective effects on isoproterenol-induced heart failure in rats through regulation of DDAH/ADMA metabolism pathway.In this study,we further investigated whether OMT could attenuate isoproterenol-induced heart failure through the regulation of COX-2/PGI2 pathway. Heart failure was induced in Sprague-Dawley rats by 5mg/kg isoproterenol subcutaneous injection for 7days...
October 29, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27796501/higher-serum-asymmetric-dimethylarginine-is-related-to-higher-risk-of-heart-failure-in-the-epic-potsdam-study
#16
Janine Wirth, Dorothee Atzler, Romina di Giuseppe, Kathrin Cordts, Juliane Menzel, Rainer H Böger, Heiner Boeing, Cornelia Weikert, Edzard Schwedhelm
L-Arginine is the substrate of endothelial nitric oxide (NO) synthase forming NO which inherits various biological cardio-protective functions. The dimethylarginines asymmetric (ADMA) and symmetric dimethylarginine (SDMA) can impair the synthesis of NO and are elevated in patients with cardiovascular disease, including heart failure (HF). We investigated the association between dimethylarginines and HF risk in a case-cohort study of the European Prospective Investigation into Cancer and Nutrition (n = 27,548), comprising a random subcohort (n = 2224 including 19 HF cases), and all remaining HF cases (n = 176) that occurred within 8...
October 28, 2016: Amino Acids
https://www.readbyqxmd.com/read/27794276/increased-plasma-asymmetric-dimethylarginine-is-associated-with-cognitive-deficits-in-patients-with-schizophrenia
#17
Yuan-Jian Yang, Jian-Wen Xiong, Ying Zhao, Jin-Qiong Zhan, Hai-Bo Chen, Kun Yan, Mao-Rong Hu, Bin Yu, Bo Wei
Cognitive deficits are a core feature of schizophrenia. Previous studies have shown that plasma asymmetric dimethylarginine (ADMA), an endogenous inhibitor of the nitric oxide synthase, was increased in patients with schizophrenia. This study aimed to investigate the association of ADMA with cognitive deficits in schizophrenia. Forty-seven patients with schizophrenia and 45 healthy control subjects were recruited in present study. Cognitive function was assessed with a neuropsychological battery including 7 neurocognitive tests...
October 17, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27760067/role-of-asymmetrical-dimethylarginine-in-diabetic-microvascular-complications
#18
Mei-Rong Du, Gui-Xia Ju, Nian-Sheng Li, Jun-Lin Jiang
Microvascular complications are the leading causes of acquired blindness, end-stage renal failure, and varieties of neuropathy associated with diabetes. Asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase inhibitor, is involved in endothelial dysfunction, oxidative stress, and inflammation associated with the progression of diabetic microvascular complications. Elevated ADMA has been detected in experimental animals and patients with diabetic microangiopathy like retinopathy, nephropathy, and neuropathy...
October 2016: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/27754224/os-32-09-the-beneficial-effect-of-losartan-on-platelet-aggregation-results-from-the-reduction-of-endogenous-asymmetric-dimethyl-arginine-in-spontaneously-hypertensive-rats
#19
Liming Peng, Ke Xia, Zhenyu Zhao, Dai Li, Zhichun Yang, Tianlun Yang
OBJECTIVE: Previous studies show that platelet aggregation and asymmetric dimethyl arginine (ADMA) are increased in hypertensive patients and animals. However, the relationship between endogenous ADMA and platelet aggregation in spontaneous hypertensive rats (SHR) remains unclear. Since Losartan can increase the nitric oxide (NO) release and ameliorate the state of thrombosis, we aimed to test whether the beneficial effect of losartan on platelet aggregation results from the reduction of ADMA generation...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27752141/diabetes-linked-transcription-factor-hnf4%C3%AE-regulates-metabolism-of-endogenous-methylarginines-and-%C3%AE-aminoisobutyric-acid-by-controlling-expression-of-alanine-glyoxylate-aminotransferase-2
#20
Dmitry V Burdin, Alexey A Kolobov, Chad Brocker, Alexey A Soshnev, Nikolay Samusik, Anton V Demyanov, Silke Brilloff, Natalia Jarzebska, Jens Martens-Lobenhoffer, Maren Mieth, Renke Maas, Stefan R Bornstein, Stefanie M Bode-Böger, Frank Gonzalez, Norbert Weiss, Roman N Rodionov
Elevated levels of circulating asymmetric and symmetric dimethylarginines (ADMA and SDMA) predict and potentially contribute to end organ damage in cardiovascular diseases. Alanine-glyoxylate aminotransferase 2 (AGXT2) regulates systemic levels of ADMA and SDMA, and also of beta-aminoisobutyric acid (BAIB)-a modulator of lipid metabolism. We identified a putative binding site for hepatic nuclear factor 4 α (HNF4α) in AGXT2 promoter sequence. In a luciferase reporter assay we found a 75% decrease in activity of Agxt2 core promoter after disruption of the HNF4α binding site...
October 18, 2016: Scientific Reports
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