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https://www.readbyqxmd.com/read/29150732/dimethylarginine-dimethylaminohydrolase-1-ddah1-is-frequently-upregulated-in-prostate-cancer-and-its-overexpression-conveys-tumor-growth-and-angiogenesis-by-metabolizing-asymmetric-dimethylarginine-adma
#1
Karthik Reddy Kami Reddy, Chandrashekhar Dasari, Divya Duscharla, Bhukya Supriya, N Sai Ram, M V Surekha, Jerald Mahesh Kumar, Ramesh Ummanni
Tissue microarray analysis confirmed higher dimethylarginine dimethylaminohydrolase-1 (DDAH1) expression in prostate cancer (PCa) compared to benign and normal prostate tissues. DDAH1 regulates nitric oxide (NO) production by degrading endogenous nitric oxide synthase (NOS) inhibitor, asymmetric dimethylarginine (ADMA). This study examined whether DDAH1 has any physiological role in PCa progression. Using overexpression of DDAH1 in PCa (PC3 and LNCaP) cell lines, we found that DDAH1 promotes cell proliferation, migration and invasion by lowering ADMA levels, as well as increasing NO production...
November 17, 2017: Angiogenesis
https://www.readbyqxmd.com/read/29142954/asymmetric-dimethylarginine-adma-levels-are-lower-in-hemodialysis-patients%C3%A2-treated-with-paricalcitol
#2
Elena Oliva-Damaso, Nestor Oliva-Damaso, Francisco Rodriguez-Esparragon, Juan Payan, Alberto Marañes, Yanet Parodis, Lopez Eduardo Baamonde-Laborda, Nicanor Vega Diaz, Jose Carlos Rodriguez-Perez
Introduction: Chronic kidney disease is a major public health problem. In the last decade, it has been shown that the early stages of chronic kidney disease are associated with an inflammatory condition involving an increased risk of cardiovascular morbidity and long-term mortality. In patients with chronic kidney disease and more specifically those on hemodialysis, cardiovascular events are the most common cause of death. Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase and may be an independent risk factor for endothelial dysfunction and cardiovascular disease...
March 2017: KI Reports
https://www.readbyqxmd.com/read/29135899/new-oxidative-stress-markers-useful-in-the-diagnosis-of-acute-appendicitis-in-children-thiol-disulfide-homeostasis-and-the-asymmetric-dimethylarginine-level
#3
Bahri Elmas, Turan Yildiz, Hayrullah Yazar, Zekeriya İlçe, Ceylan Bal, Betül Özbek, Yusuf Yürümez
OBJECTIVES: The aim of this study was to evaluate 2 new oxidative stress markers, thiol/disulfide homeostasis status and the asymmetric dimethylarginine (ADMA) level, in children with acute appendicitis (AA) and to evaluate their diagnostic utility. METHODS: This case-control study included 45 patients with AA and 35 healthy children. Age, sex, white blood cell count, neutrophil-to-lymphocyte ratio, high-sensitivity C-reactive protein (hs-CRP) level, ultrasonographic findings, thiol/disulfide homeostasis parameters (native and total thiol levels, native thiol/total thiol ratios [antioxidant parameters], and disulfide, disulfide/native thiol, and disulfide/total thiol ratios [oxidant parameters]), and the ADMA level were compared between the 2 groups...
November 14, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29129236/effects-of-betaine-supplementation-on-nitric-oxide-metabolism-atherosclerotic-parameters-and-fatty-liver-in-guinea-pigs-fed-a-high-cholesterol-plus-methionine-diet
#4
Zeynep Küskü-Kiraz, Sema Genc, Seldağ Bekpınar, Yeşim Ünlücerci, Aydın Çevik, Vakur Olgaç, Figen Gürdöl, Müjdat Uysal
OBJECTIVE: The aim of this study was to investigate the effect of high cholesterol (CHOL) and CHOL + methionine (MET) diets on atherogenic and oxidative index parameters and on the factors that influence nitric oxide (NO) bioavailability. Also, attempts were made to determine whether dietary betaine (BET) resulted in any improvement in the changes that occurred after CHOL + MET administration. METHODS: Guinea pigs were fed chow containing 1.5% CHOL with or without 2% MET for 10 wk...
January 2018: Nutrition
https://www.readbyqxmd.com/read/29128547/associations-between-asymmetric-dimethylarginine-adma-nitrite-dependent-renal-carbonic-anhydrase-activity-and-plasma-testosterone-levels-in-hypogonadal-men
#5
Dimitrios Tsikas, Manfred Kinzel
BACKGROUND: Circulating inorganic nitrite (NO2(-)) is an abundant nitric oxide (NO) reservoir. Renal carbonic anhydrase (CA) mediates the absorption of urinary nitrite. The urinary nitrate-to-nitrite molar ratio UNOxR is a measure of nitrite-dependent renal CA activity. The CA family is also involved in the bioactivation of nitrite to S-nitrosothiols and NO. Thus, CA isoforms may combat atherosclerosis. METHODS: In plasma and urine of ten hypogonadal men we measured the major NO metabolites nitrite and nitrate, and the endogenous inhibitor of NO synthase (NOS) asymmetric dimethylarginine (ADMA) before and after a 24-weeks testosterone treatment to normalize plasma testosterone levels...
November 8, 2017: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/29121934/effect-of-rosuvastatin-on-fasting-and-postprandial-endothelial-biomarker-levels-and-microvascular-reactivity-in-patients-with-type-2-diabetes-and-dyslipidemia-a-preliminary-report
#6
Kyoung Min Kim, Kyong Yeun Jung, Han Mi Yun, Seo Young Lee, Tae Jung Oh, Hak Chul Jang, Soo Lim
BACKGROUND: The cardiovascular benefits of statins have been proven, but their effect on circulation in small vessels has not been examined fully. We investigated the effect of 20 mg rosuvastatin on biomarkers, including paraoxonase-1 (PON-1) and asymmetric dimethylarginine (ADMA), and on microvascular reactivity. METHOD: We enrolled 20 dyslipidemic patients with type 2 diabetes and 20 age- and body mass index (BMI)-matched healthy controls. Rosuvastatin (20 mg/day) was given to the patient group for 12 weeks...
November 9, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29120671/erythropoietin-reduces-collagen-deposition-after-myocardial-infarction-but-does-not-improve-cardiac-function
#7
Fernanda G Pessoa, Charles Mady, Keila C B Fonseca, Adriana M Oliveira-Fonoff, Vera M C Salemi, Mauricio R Jordao, Fabio Fernandes, Felix J A Ramires
Myocardial remodeling includes inappropriate collagen deposition in the interstitium. Erythropoietin (EPO) may have cardioprotective effects. We aimed to assess the role of EPO on myocardial remodeling during the chronic phase. We studied 60 Wistar rats divided into Control (CT), Control+EPO (CT+EPO), Infarcted+EPO (MI+EPO), and Infarcted (MI). The interstitial collagen volume fraction (ICVF) was quantified. Echocardiography was performed. We quantified ADMA and glutathione by ELISA, and RT-PCR to assess apoptosis and inflammation...
November 9, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/29119338/elevated-levels-of-adma-are-associated-with-lower-ddah2-and-higher-prmt1-in-lps-induced-endometritis-rats
#8
Hong-Bo Xiao, Guo-Guang Sui, Xiang-Yang Lu, Zhi-Liang Sun
Chronic endometritis is a continuous inflammation of uterine endometrium. Recent research has shown that higher asymmetric dimethylarginine (ADMA) levels contribute to endothelial dysfunction. In the present study, we tested whether there is a correlation between endometritis and ADMA in LPS-induced endometritis rat and the mechanisms involved. Thirty-six rats were divided into two groups: blank control group and rat model of endometritis group. The entire infused uterus were removed to observe the changes of histopathology, production of myeloperoxidase (MPO), tumor necrosis factor-α (TNF-α), interleukin (IL)-6, 8-isoprostane, and reactive oxygen species (ROS), and gene expression of dimethylarginine dimethylaminohydrolase 2 (DDAH2), protein-methyl transferase 1 (PRMT1), TNF-α, and IL-6...
November 8, 2017: Inflammation
https://www.readbyqxmd.com/read/29104939/asymmetric-dimethylarginine-does-not-predict-early-access-events-in-hemodialysis-patients-with-brachiocephalic-fistula-access
#9
Mary Hammes, Rita McGill, Promila Dhar, Rama S Madhurapantula
Background: Vascular access for hemodialysis is best provided by an arteriovenous fistula (AVF). AVF fail primarily because of neointimal hyperplasia. Asymmetric dimethlyarginine (ADMA) is a naturally occurring analogue of L-arginine, which is elevated in renal failure and impairs endothelial cell function. ADMA inhibits nitric oxide synthetase, leading to impaired nitric oxide production and contributing to the development of neointimal hyperplasia. ADMA was measured at the time of AVF placement to evaluate associations with access failure...
August 2017: Int J Nephrol Kidney Fail
https://www.readbyqxmd.com/read/29101459/symmetric-dimethylarginine-sdma-outperforms-asymmetric-dimethylarginine-adma-and-other-methylarginines-as-predictor-of-renal-and-cardiovascular-outcome-in-non-dialysis-chronic-kidney-disease
#10
Insa E Emrich, Adam M Zawada, Jens Martens-Lobenhoffer, Danilo Fliser, Stefan Wagenpfeil, Gunnar H Heine, Stefanie M Bode-Böger
BACKGROUND: Chronic kidney disease (CKD) is associated with increased risk of renal and cardiovascular events. It has been claimed that endogenous methylarginines, asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA), are contributing factors. However, earlier studies were partly contradictory and mainly focused on prevalent dialysis patients. Moreover, the potential contribution of degradation products, such as acetylated ADMA and SDMA (AcADMA and AcSDMA) and other methylarginines including L-N(G)-monomethylarginine (LNMMA) remains unknown...
November 3, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29099056/ammonia-reduces-intracellular-asymmetric-dimethylarginine-in-cultured-astrocytes-stimulating-its-y%C3%A2-%C2%BAlat2-carrier-mediated-loss
#11
Krzysztof Milewski, Małgorzata Bogacińska-Karaś, Inez Fręśko, Wojciech Hilgier, Radosław Jaźwiec, Jan Albrecht, Magdalena Zielińska
Previously we had shown that ammonia stimulates nitric oxide (NO) synthesis in astrocytes by increasing the uptake of the precursor amino acid, arginine via the heteromeric arginine/glutamine transporter y⁺LAT2. Ammonia also increases the concentration in the brain of the endogenous inhibitor of nitric oxide synthases (NOS), asymmetric dimethylarginine (ADMA), but distribution of ADMA surplus between the intraastrocytic and extracellular compartments of the brain has not been studied. Here we tested the hypothesis that ammonia modulates the distribution of ADMA and its analog symmetric dimethylarginine (SDMA) between the two compartments of the brain by competition with arginine for the y⁺LAT2 transporter...
November 2, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29096857/adma-reduction-does-not-protect-mice-with-streptozotocin-induced-diabetes-mellitus-from-development-of-diabetic-nephropathy
#12
Roman N Rodionov, Annett Heinrich, Silke Brilloff, Natalia Jarzebska, Jens Martens-Lobenhoffer, Stefanie M Bode-Böger, Vladimir T Todorov, Christian P M Hugo, Norbert Weiss, Bernd Hohenstein
BACKGROUND AND AIMS: Cardiovascular disease is the major cause of morbidity and mortality in the world. Diabetes and its complications, such as diabetic nephropathy, dramatically increase cardiovascular risk. Association studies suggest that asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthases, plays a role in the pathogenesis of diabetic nephropathy. The major pathway of ADMA catabolism is hydrolysis by dimethylarginine dimethylaminohydrolase 1 (DDAH1)...
November 2017: Atherosclerosis. Supplements
https://www.readbyqxmd.com/read/29074293/relationship-between-asymmetric-dimethylarginine-nitrite-and-genetic-polymorphisms-impact-on-erectile-dysfunction-therapy
#13
Ana Maria Milanez Azevedo, Guilhermo Brites-Anselmi, Lucas Cezar Pinheiro, Vanessa de Almeida Belo, Fernanda Borchers Coeli-Lacchini, Carlos Augusto Fernandes Molina, Murilo Ferreira de Andrade, Silvio Tucci, Emilio Hirsch, Jose Eduardo Tanus-Santos, Riccardo Lacchini
Sildenafil is the most used treatment of erectile dysfunction, however a large part of patients do not respond to therapy. This drug enhances nitric oxide (NO) signaling, and therefore factors that alter NO production may impact this drug responsiveness. Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of all NO synthases, and is metabolized by Dimethylarginine Dimethilaminohydrolase (DDAH) 1 and 2. Here we aimed to assess the relationship between plasma levels of ADMA and nitrite (marker of nitric oxide production) with Sildenafil responsiveness...
October 23, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/29070803/mir-193b-regulates-breast-cancer-cell-migration-and-vasculogenic-mimicry-by-targeting-dimethylarginine-dimethylaminohydrolase-1
#14
Julie-Ann Hulin, Sara Tommasi, David Elliot, Dong Gui Hu, Benjamin C Lewis, Arduino A Mangoni
Dimethylarginine dimethylaminohydrolase 1 (DDAH1) is responsible for metabolism of an endogenous inhibitor of nitric oxide synthase (NOS), asymmetric dimethylarginine (ADMA), which plays a key role in modulating angiogenesis. In addition to angiogenesis, tumours can establish a vascular network by forming vessel-like structures from tumour cells; a process termed vasculogenic mimicry (VM). Here, we identified over-expression of DDAH1 in aggressive MDA-MB-231, MDA-MB-453 and BT549 breast cancer cell lines when compared to normal mammary epithelial cells...
October 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29055959/impaired-arginine-metabolism-coupled-to-a-defective-redox-conduit-contributes-to-low-plasma-nitric-oxide-in-polycystic-ovary-syndrome
#15
Meera B Krishna, Annu Joseph, Philip Litto Thomas, Belinda Dsilva, Sathy M Pillai, Malini Laloraya
BACKGROUND: Though oxidative stress is associated with Polycystic Ovary Syndrome (PCOS), the status of nitric oxide is still unclear. Nitric Oxide (NO) plays pivotal roles in many physiological functions which are compromised in PCOS. Our recent study reveals lowered T-regulatory cells (Tregs) in PCOS, and Treg generation is known to be regulated by NO levels. However concrete evidences are lacking on mechanisms modulating NO levels under PCOS. METHODS: This is a retrospective case-control cohort study, comprised of PCOS women (N=29) and normal menstruating women as controls (N=20)...
October 20, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29053806/independent-association-of-plasma-hydroxysphingomyelins-with-physical-function-in-the-atherosclerosis-risk-in-communities-aric-study
#16
Danni Li, Jeffrey R Misialek, Fangying Huang, B Gwen Windham, Fang Yu, Alvaro Alonso
Background: Plasma metabolites such as phosphatidylcholines (PCs) and sphingomyelins (SMs) are associated with in age-related cognitive decline. However, their relations to age-related physical function decline remain largely unknown. Methods: We examined the cross-sectional relations of 12 plasma metabolites (including 4 PCs and 4 SMs) with physical function in 383 older adults in the Atherosclerosis Risk in Communities study at the fifth exam (2011-13, mean age [standard deviation (SD)]: 78...
October 19, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29048108/renin-angiotensin-system-blockade-promotes-a-cardio-renal-protection-in-albuminuric-homozygous-sickle-cell-patients
#17
Jean-Philippe Haymann, Nadjib Hammoudi, Katia Stankovic Stojanovic, Frederic Galacteros, Anoosha Habibi, Virginie Avellino, Pablo Bartolucci, Yahia Benzerara, Jean-Benoit Arlet, Morad Djebbar, Emmanuel Letavernier, Gilles Grateau, Nathalie Tabibzadeh, Alexei Girshovich, Michel Chaignon, Robert Girot, Pierre Levy, Francois Lionnet
The management of sickle cell nephropathy (SCN) at an early stage is an important issue to prevent renal and cardiovascular morbidity and mortality. This study aimed to evaluate in this population, whether angiotensin converting enzyme inhibitors (ACEIs) treatment could exert a cardio-renal protection in a SCN cohort. Forty-two SCN patients (urine albumin:creatinine ratio (ACR) > 10 mg/mmol) were treated with ACEIs for 6 months, then evaluated for ACR, measured glomerular filtration rate (mGFR) together with haematological and cardiovascular parameters...
October 19, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/29035782/opposing-effects-of-rheumatoid-arthritis-and-low-dose-prednisolone-on-arginine-metabolomics
#18
Anjana Radhakutty, Brenda L Mangelsdorf, Sophie M Drake, Andrew Rowland, Malcolm D Smith, Arduino A Mangoni, Campbell H Thompson, Morton G Burt
BACKGROUND AND AIMS: The effects of low dose prednisolone on circulating markers of endothelial function, the arginine metabolites asymmetric dimethyl arginine (ADMA), mono methyl arginine (MMA), and homoarginine, are uncertain. We assessed whether patients with rheumatoid arthritis have perturbations in arginine metabolite concentrations that are reversed by low dose prednisolone. METHODS: Eighteen rheumatoid arthritis patients who had not taken prednisolone for >6 months (non-glucocorticoid (GC) users), 18 rheumatoid arthritis patients taking continuous oral prednisolone (6...
November 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29024866/diclofenac-but-not-celecoxib-improves-endothelial-function-in-rheumatoid-arthritis-a-study-in-adjuvant-induced-arthritis
#19
Frank Verhoeven, Perle Totoson, Christine Marie, Anne Prigent-Tessier, Daniel Wendling, Maude Tournier-Nappey, Clément Prati, Céline Demougeot
BACKGROUND AND AIMS: We aimed at investigating the effect of celecoxib (COX-2 selective inhibitor) and diclofenac (non-selective COX inhibitor) on endothelial function, and at identifying the underlying mechanisms in adjuvant-induced arthritis (AIA). METHODS: At the first signs of AIA, diclofenac (5 mg/kg twice a day, i.p), celecoxib (3 mg/kg/day, i.p) or saline (Vehicle) was administered for 3 weeks. Endothelial function was studied in aortic rings relaxed with acetylcholine (Ach) with or without inhibitors of NOS, arginase, EDHF and superoxide anions (O2(-°)) production...
November 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29024618/association-of-serum-asymmetric-dimethylarginine-homocysteine-and-l-arginine-concentrations-during-early-pregnancy-with-hypertensive-disorders-of-pregnancy
#20
Ei Maruta, Jingwen Wang, Tomomi Kotani, Hiroyuki Tsuda, Tomoko Nakano, Kenji Imai, Seiji Sumigama, Yoshimitsu Niwa, Takashi Mitsui, Shigeru Yoshida, Mamoru Yamashita, Akihiro Nawa, Koji Tamakoshi, Hiroaki Kajiyama, Fumitaka Kikkawa
BACKGROUND: Our previous study suggested that a lower l-arginine level (<70μM) at early gestation is associated with pregnancy-induced hypertension. The maternal asymmetric dimethylarginine (ADMA) and homocysteine (Hcy) concentrations also have been reported to be increased in hypertensive disorders of pregnancy (HDP). These molecules have a key role in metabolism of nitric oxide. The aim of this study is to determine the most useful predictor of HDP at early gestation. METHODS: The concentrations of ADMA and Hcy at each of three periods in normal pregnancy were determined, and the values compared between the normal pregnancy and HDP groups...
October 10, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
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