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https://www.readbyqxmd.com/read/28074304/evaluation-of-endothelial-dysfunction-in-patients-with-familial-mediterranean-fever-the-relationship-between-the-levels-of-asymmetric-dimethylarginine-and-endocan-with-carotid-intima-media-thickness-and-endothelium-dependent-vasodilation
#1
Veysel Ozalper, Muammer Kara, Alpaslan Tanoglu, Ibrahim Cetındaglı, Coskun Ozturker, Yusuf Hancerlı, Serdar Hıra, Kemal Kara, Yavuz Beyazıt, Yusuf Yazgan
It has been suggested that there is an ongoing subclinical inflammation in familial Mediterranean fever (FMF) patients also in attack-free periods as well. Due to this ongoing inflammation, endothelial dysfunction (ED) may develop. Previously, ED has been suggested to increase the risk of the atherosclerosis and cardiovascular disease (CVD). Endocan is recognized as a specific molecule of the endothelium and has been shown to increase in some cases associated with inflammation. However, there is not sufficient data whether those with FMF could develop ED in the early period of life...
January 10, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28068281/pathophysiological-role-of-adiponectin-leptin-and-asymmetric-dimethylarginine-in-the-process-of-atherosclerosis
#2
Daniela Iv Koleva, Maria M Orbetzova, Julia G Nikolova, Tanya I Deneva
Adipose tissue is recognized as a rich source of proinflammatory mediators that may directly contribute to vascular injury, insulin resistance, and atherogenesis. Many studies have shown that adiponectin has antiatherogenic and anti-inflammatory properties. Adiponectin acts not only as a factor increasing insulin sensitivity, and the protective effect may result from its ability to suppress production of proinflammatory cytokines. It negatively regulates the expression of TNF-alpha and C-reactive protein (CRP) in adipose tissue; reduces expression of vascular and intracellular adhesion molecules (VCAM-1, ICAM-1), E-selectin, interleukin-8 (IL-8)...
December 1, 2016: Folia Medica
https://www.readbyqxmd.com/read/28058997/deletion-of-admb-gene-encoding-a-fungal-adam-affects-cell-wall-construction-in-aspergillus-oryzae
#3
Takuji Kobayashi, Hiroshi Maeda, Michio Takeuchi, Youhei Yamagata
Mammals possess a unique signaling system based on the proteolytic mechanism of a disintegrin and metalloproteinases (ADAMs) on the cell surface. We found two genes encoding ADAMs in Aspergillus oryzae and named them admA and admB. We produced admA and admB deletion strains to elucidate their biological function and clarify whether fungal ADAMs play a similar role as in mammals. The ∆admA∆admB and ∆admB strains were sensitive to cell wall-perturbing agents, congo red, and calcofluor white. Moreover, the two strains showed significantly increased weights of total alkali-soluble fractions from the mycelial cell wall compared to the control strain...
January 6, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28053285/protective-effect-of-tanshinone-iia-against-cardiac-hypertrophy-in-spontaneously-hypertensive-rats-through-inhibiting-the-cys-c-wnt-signaling-pathway
#4
Jun Feng, Hua-Wen Chen, Li-Juan Pi, Jin Wang, Da-Qian Zhan
The study aimed to investigate the protective effect of tanshinone IIA against cardiac hypertrophy in spontaneously hypertensive rats (SHRs) through the Cys-C/Wnt signaling pathway. Thirty SHRs were randomly divided into cardiac hypertrophy, low- and high-dose tanshinone IIA groups. Ten Wistar-Kyoto rats were selected as control group. The systolic blood pressure (SBP), heart weight (HW), left ventricular weight (LVW) and body weight (BW) of all rats were recorded. HE staining and qRT-PCR were applied to observe the morphology of myocardial tissue and mRNA expressions of COL1A1 and COL3A1...
December 28, 2016: Oncotarget
https://www.readbyqxmd.com/read/28052095/metabolomic-profiling-in-individuals-with-a-failing-kidney-allograft
#5
Roberto Bassi, Monika A Niewczas, Luigi Biancone, Stefania Bussolino, Sai Merugumala, Sara Tezza, Francesca D'Addio, Moufida Ben Nasr, Alessandro Valderrama-Vasquez, Vera Usuelli, Valentina De Zan, Basset El Essawy, Massimo Venturini, Antonio Secchi, Francesco De Cobelli, Alexander Lin, Anil Chandraker, Paolo Fiorina
BACKGROUND: Alteration of certain metabolites may play a role in the pathophysiology of renal allograft disease. METHODS: To explore metabolomic abnormalities in individuals with a failing kidney allograft, we analyzed by liquid chromatography-mass spectrometry (LC-MS/MS; for ex vivo profiling of serum and urine) and two dimensional correlated spectroscopy (2D COSY; for in vivo study of the kidney graft) 40 subjects with varying degrees of chronic allograft dysfunction stratified by tertiles of glomerular filtration rate (GFR; T1, T2, T3)...
2017: PloS One
https://www.readbyqxmd.com/read/28042453/design-and-synthesis-of-selective-small-molecule-inhibitors-of-coactivator-associated-arginine-methyltransferase-1-carm1
#6
H Ü Kaniskan, M S Eram, J Liu, D Smil, M L Martini, Y Shen, V Santhakumar, P J Brown, C Arrowsmith, M Vedadi, J Jin
Coactivator-associated arginine methyltransferase 1 (CARM1) is a type I protein arginine methyltransferase (PRMT) that catalyzes the conversion of arginine into monomethylarginine (MMA) and further into asymmetric dimethylarginine (ADMA). CARM1 methylates histone 3 arginines 17 and 26, as well as numerous non-histone proteins including CBP/p300, SRC-3, NCOA2, PABP1, and SAP49, while also functioning as a coactivator for various proteins that have been linked to cancer such as p53, NF-κβ, β-catenin, E2F1 and steroid hormone receptor ERα...
September 1, 2016: MedChemComm
https://www.readbyqxmd.com/read/28038718/preoperative-values-of-inflammatory-markers-predict-clinical-outcomes-in-patients-after-cabg-regardless-of-the-use-of-cardiopulmonary-bypass
#7
Dariusz Plicner, Jarosław Stoliński, Marcin Wąsowicz, Bugusław Gawęda, Hubert Hymczak, Bogusław Kapelak, Rafał Drwiła, Anetta Undas
OBJECTIVE: The impact of systemic inflammation on clinical outcomes after CABG surgery is still controversial. In this study, we evaluated the impact of the markers of inflammation, endothelial damage and platelet activation on clinical outcomes after on- and off-pump CABG. METHODS: A group of 191 consecutive on- and off-pump CABG patients were prospectively studied. Blood samples were drawn before surgery, 18-36h after the procedure and 5-7 days postoperatively and analyzed for 8-iso-prostaglandin F2α (8-iso-PGF2α), asymmetric dimethylarginine (ADMA) and β-thromboglobulin (β-TG)...
December 2016: Indian Heart Journal
https://www.readbyqxmd.com/read/28027911/effects-of-vitamin-d3-on-asymmetric-and-symmetric-dimethylarginine-in-arterial-hypertension
#8
REVIEW
M R Grübler, M Gaksch, K Kienreich, N D Verheyen, J Schmid, C Müllner, G Richtig, H Scharnagl, C Trummer, V Schwetz, A Meinitzer, B Pieske, W März, A Tomaschitz, S Pilz
BACKGROUND AND AIMS: Accumulating evidence has proposed a correlation between vitamin D (25(OH)D) insufficiency and cardiovascular (CV) disease. Vitamin D associated effects on endothelial function have been suggested to be a possible culprit. The present study investigated the association of vitamin D3 treatment on markers of endothelial dysfunction in patients with arterial hypertension. METHODS AND RESULTS: The Styrian Vitamin D Hypertension Trial is a double-blind, placebo-controlled, single-centre study conducted at the Medical University of Graz, Austria...
December 24, 2016: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28013452/plasma-apelin-and-asymmetric-dimethylarginine-adma-levels-shortly-after-laparoscopic-greater-curvature-plication
#9
Elias Khajeh, Nekoo Panahi, Atefeh Golpaie, Sepideh Hosseini Shirvani, Mohsen Afarideh, Omid Ghamarnejad, Mohammad Talebpour, Mohammad Javad Hosseinzadeh-Attar
OBJECTIVES: We sought to investigate the short-term effect of weight loss following restrictive bariatric surgery on plasma concentrations of apelin and asymmetric dimethylarginine (ADMA) in individuals with morbid obesity. SUBJECTS/METHODS: Thirty-seven morbidly obese individuals underwent laparoscopic greater curvature plication (LGCP). Anthropometric indices and plasma concentrations high-sensitivity C-reactive protein (hsCRP), apelin, and ADMA were measured before and 6 weeks after LGCP...
December 24, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27993872/endocan-tgf-beta-and-adma-as-risk-factors-for-endothelial-dysfunction-and-possible-vascular-disease-in-patients-with-subclinical-hypothyroidism
#10
Dilek Arpaci, Engin Karakece, Aysel Gurkan Tocoglu, Hasan Ergenc, Gonul Gurol, Ihsan Hakki Ciftci, Ali Tamer
PURPOSE: Although the relationship between atherosclerosis and overt hypothyroidism has been confirmed, it remains controversial in cases of subclinical hypothyroidism. Higher TSH and similar T4 suggest differences in set-points or differences due to diagnostic limitations regarding subclinical hypothyroidism. Endothelial dysfunction (ED) is a marker rather than a precursor of cardiovascular disease. Asymmetric dimethylarginine (ADMA) and endocan are known as novel markers of ED in various diseases...
December 2016: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/27986842/effect-of-occupational-exposure-to-lead-on-new-risk-factors-for-cardiovascular-diseases
#11
Adam Prokopowicz, Andrzej Sobczak, Magdalena Szuła-Chraplewska, Marzena Zaciera, Jolanta Kurek, Izabela Szołtysek-Bołdys
OBJECTIVE: The cardiovascular effects of lead are caused primarily through an effect on blood pressure but are not just limited to an increased risk of hypertension. The aim of our study was to determine to what extent chronic exposure to lead affects new risk factors for cardiovascular disease (CVD) development, such as biomarkers of inflammation (C reactive protein (CRP) and fibrinogen) and biomarkers of endothelial dysfunction (homocysteine, asymmetric dimethylarginine (ADMA) and L-homoarginine)...
December 16, 2016: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/27957828/protective-effects-of-low-dose-rosuvastatin-on-isoproterenol-induced-chronic-heart-failure-in-rats-by-regulation-of-ddah-adma-no-pathway
#12
Ru Zhou, Ping Ma, Aiqin Xiong, Yehua Xu, Yang Wang, Qingbin Xu
Cardiovascular disease is the leading cause of death with high morbidity and mortality and chronic heart failure is the terminal phase of it. This study aims to investigate the protective effects of the low dose rosuvastatin on isoproterenol-induced chronic heart failure and to explore the possible related mechanisms METHODS: Male Sprague-Dawley rats were given isoproterenol 5 mg/kg once a day for 7 days to establish heart failure model by subcutaneous injection. Simultaneously, low dose rosuvastatin (5 mg/kg) was oral administrated from day 1 to day 14...
December 13, 2016: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/27942587/chorioretinal-thinning-in-chronic-kidney-disease-links-to-inflammation-and-endothelial-dysfunction
#13
Craig Balmforth, Job J M H van Bragt, Titia Ruijs, James R Cameron, Robert Kimmitt, Rebecca Moorhouse, Alicja Czopek, May Khei Hu, Peter J Gallacher, James W Dear, Shyamanga Borooah, Iain M MacIntyre, Tom M C Pearson, Laura Willox, Dinesh Talwar, Muriel Tafflet, Christophe Roubeix, Florian Sennlaub, Siddharthan Chandran, Baljean Dhillon, David J Webb, Neeraj Dhaun
BACKGROUND. Chronic kidney disease (CKD) is strongly associated with cardiovascular disease and there is an established association between vasculopathy affecting the kidney and eye. Optical coherence tomography (OCT) is a novel, rapid method for high-definition imaging of the retina and choroid. Its use in patients at high cardiovascular disease risk remains unexplored. METHODS. We used the new SPECTRALIS OCT machine to examine retinal and retinal nerve fiber layer (RNFL) thickness, macular volume, and choroidal thickness in a prospective cross-sectional study in 150 subjects: 50 patients with hypertension (defined as a documented clinic BP greater than or equal to 140/90 mmHg (prior to starting any treatment) with no underlying cause identified); 50 with CKD (estimated glomerular filtration rate (eGFR) 8-125 ml/min/1...
December 8, 2016: JCI Insight
https://www.readbyqxmd.com/read/27930821/assessment-of-asymmetrical-dimethylarginine-metabolism-in-patients-with-critical-illness
#14
Rawia A Ghashut, Scott Blackwell, Sylvia Ryan, Laura Willox, Donald C McMillan, John Kinsella, Dinesh Talwar
BACKGROUND: Critically ill patients experience metabolic disorders including hypercatabolic state and hyperglycaemia and these are associated with poor outcome. Hyperglycaemia and asymmetric dimethylarginine (ADMA) are reported to have significant influences on endothelial dysfunction. The aim of the present study was to examine the relationship between plasma asymmetric dimethylarginine (ADMA) and related arginine metabolism in patients with critical illness. MATERIALS AND METHODS: Two venous blood samples (EDTA) (104 patients), on admission and follow up sample in the last day in ICU (died or discharge sample median 7, IQR 6-8, range 5-15)...
December 8, 2016: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27918455/targeting-on-asymmetric-dimethylarginine-related-nitric-oxide-reactive-oxygen-species-imbalance-to-reprogram-the-development-of-hypertension
#15
REVIEW
You-Lin Tain, Chien-Ning Hsu
Adult-onset diseases, including hypertension, can originate from early life, known as the developmental origins of health and disease (DOHaD). Because the developing kidney is vulnerable to early-life insults, renal programming is considered key in the developmental programming of hypertension. Asymmetric dimethylarginine (ADMA), an endogenous nitric oxide (NO) synthase inhibitor, can regulate the NO-reactive oxygen species (ROS) balance, and is involved in the development of hypertension. Reprogramming interventions aimed at NO-ROS balance can be protective in both genetic and developmentally programmed hypertension...
December 2, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27914500/effect-of-l-arginine-asymmetric-dimethylarginine-and-symmetric-dimethylarginine-on-ischemic-heart-disease-risk-a-mendelian-randomization-study
#16
Shiu Lun Au Yeung, Shi Lin Lin, Hung San Hugh Simon Lam, Catherine Mary Schooling
BACKGROUND: l-arginine is a commonly consumed dietary conditional essential amino acid found in food items and supplements, which is closely related to asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA). l-arginine is thought to increase nitric oxide and be cardioprotective, whereas ADMA and SDMA may inhibit nitric oxide synthesis and increase cardiovascular disease risk. Unexpectedly, l-arginine increased mortality in a small trial. To clarify the effects of these potential targets of intervention, we assessed the risk of ischemic heart disease (IHD) by genetically determined l-arginine, ADMA, and SDMA...
December 2016: American Heart Journal
https://www.readbyqxmd.com/read/27909412/modeling-disease-progression-angiotensin-ii-indirectly-inhibits-nitric-oxide-production-via-adma-accumulation-in-spontaneously-hypertensive-rats
#17
Haidong Wang, Hao Jiang, Haochen Liu, Xue Zhang, Guimei Ran, Hua He, Xiaoquan Liu
Nitric oxide (NO) production impairment is involved in the onset and development of hypertension. Although NO production impairment in spontaneously hypertensive rat (SHR) has been reported in a variety of researches, the time course of this progressive procedure, as well as its relationship with asymmetric dimethylarginine (ADMA) and angiotensin II (Ang II), has not been quantified. The aim of this research is to establish a mechanism-based disease progression model to assess Ang II and ADMA's inhibition of NO production in SHR's disease progression with/without ramipril's intervention...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27886426/retraction-statement-high-volumetric-performance-aligned-nano-porous-microwave-exfoliated-graphite-oxide-based-electrochemical-capacitors-and-aligned-nano-porous-microwave-exfoliated-graphite-oxide-ionic-actuators-with-high-strain-and-elastic-energy-density
#18
(no author information available yet)
These articles first published on 15 August 2013 and 21 August 2013 on the Wiley Online Library have been retracted at the request of the Research Integrity Officer (RIO) of The Pennsylvania State University, in agreement with the corresponding authors, the journal's Editor-in-Chief, and Wiley-VCH Verlag GmbH & Co. KGaA, because portions of the reported results cannot be considered reliable or reproducible. Following an investigation by the RIO of The Pennsylvania State University, it was found that the data in Figure 2a,b and Figure S1a,b (Supporting Information) of the article with DOI: 10...
2016: Advanced Materials
https://www.readbyqxmd.com/read/27885576/asymmetric-dimethylarginine-and-hepatic-encephalopathy-cause-effect-or-association
#19
Anna Czarnecka, Krzysztof Milewski, Magdalena Zielińska
The methylated derivative of L-arginine, asymmetric dimethylarginine (ADMA) is synthesized in different mammalian tissues including the brain. ADMA acts as an endogenous, nonselective, competitive inhibitor of all three isoforms of nitric oxide synthase (NOS) and may limit L-arginine supply from the plasma to the enzyme via reducing its transport by cationic amino acid transporters. Hepatic encephalopathy (HE) is a relatively frequently diagnosed complex neuropsychiatric syndrome associated with acute or chronic liver failure, characterized by symptoms linked with impaired brain function leading to neurological disabilities...
November 25, 2016: Neurochemical Research
https://www.readbyqxmd.com/read/27884754/increased-serum-concentrations-of-asymmetric-dimethylarginine-adma-in-patients-with-early-onset-coronary-artery-disease
#20
Chao Xuan, Zhen-Fang Liu, Qing Wang, Fen-Fen Guo, Xiao Zhang, Guo-Wei He, Li-Min Lun
BACKGROUND: Asymmetric dimethylarginine (ADMA) has been associated with an increased risk of cardiovascular disease. We investigated the role of serum ADMA concentrations in early-onset coronary artery disease (EOCAD). METHODS: Candidates for coronary artery angiography (age<50y for men and <55y for women) who met the inclusion criteria were enrolled in this study. Serum concentrations of ADMA were determined using ELISA. Severity of coronary atherosclerosis was estimated by number of diseased vessels...
January 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
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