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Gennady V Roshchupkin, Hieab H Adams, Sven J van der Lee, Meike W Vernooij, Cornelia M van Duijn, Andre G Uitterlinden, Aad van der Lugt, Albert Hofman, Wiro J Niessen, Mohammad A Ikram
The neural substrate of genetic risk variants for Alzheimer's disease (AD) remains unknown. We studied their effect on healthy brain morphology to provide insight into disease etiology in the preclinical phase. We included 4071 nondemented, elderly participants of the population-based Rotterdam Study who underwent brain magnetic resonance imaging and genotyping. We performed voxel-based morphometry (VBM) on all gray-matter voxels for 19 previously identified, common AD risk variants. Whole-brain expression data from the Allen Human Brain Atlas was used to examine spatial overlap between VBM association results and expression of genes in AD risk loci regions...
September 4, 2016: Neurobiology of Aging
YuHong Fu, Jen-Hsiang T Hsiao, George Paxinos, Glenda M Halliday, Woojin Scott Kim
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by dementia and abnormal deposits of aggregated amyloid-β in the brain. Recent genome-wide association studies have revealed that ABCA7 is strongly associated with AD. In vitro evidence suggests that the role of ABCA7 is related to phagocytic activity. Deletion of ABCA7 in a mouse model of AD exacerbates cerebral amyloid-β plaque load. However, the biological role of ABCA7 in AD brain pathogenesis is unknown. We show that ABCA7 is highly expressed in microglia and when monocytes are differentiated into macrophages...
September 6, 2016: Journal of Alzheimer's Disease: JAD
Michelle Bamji-Mirza, Yan Li, Dema Najem, Qing Yan Liu, Douglas Walker, Lih-Fen Lue, Jacek Stupak, Kenneth Chan, Jianjun Li, Mahdi Ghani, Ze Yang, Ekaterina Rogaeva, Wandong Zhang
Alzheimer's disease (AD) is characterized by extracellular deposits of amyloid-β (Aβ) in the brain. ABCA7 is highly expressed in the brain and a susceptibility gene for late-onset AD (LOAD). The minor alleles at two ABCA7 single-nucleotide polymorphisms (SNPs), rs3764650 (T>G; intron13) and rs3752246 at a predicted myristoylation site (C>G; exon33; p.Gly1527Ala), are significantly associated with LOAD risk; however, the mechanism of this association is unknown. Functional consequences of both SNPs were examined in HEK293 and CHO cells stably expressing AβPPSwe...
June 13, 2016: Journal of Alzheimer's Disease: JAD
Celeste Sassi, Michael A Nalls, Perry G Ridge, Jesse R Gibbs, Jinhui Ding, Michelle K Lupton, Claire Troakes, Katie Lunnon, Safa Al-Sarraj, Kristelle S Brown, Christopher Medway, Naomi Clement, Jenny Lord, James Turton, Jose Bras, Maria R Almeida, Henne Holstege, Eva Louwersheimer, Wiesje M van der Flier, Philip Scheltens, John C Van Swieten, Isabel Santana, Catarina Oliveira, Kevin Morgan, John F Powell, John S Kauwe, Carlos Cruchaga, Alison M Goate, Andrew B Singleton, Rita Guerreiro, John Hardy
Genome-wide association studies (GWASs) have been effective approaches to dissect common genetic variability underlying complex diseases in a systematic and unbiased way. Recently, GWASs have led to the discovery of over 20 susceptibility loci for Alzheimer's disease (AD). Despite the evidence showing the contribution of these loci to AD pathogenesis, their genetic architecture has not been extensively investigated, leaving the possibility that low frequency and rare coding variants may also occur and contribute to the risk of disease...
October 2016: Neurobiology of Aging
Holly N Cukier, Brian W Kunkle, Badri N Vardarajan, Sophie Rolati, Kara L Hamilton-Nelson, Martin A Kohli, Patrice L Whitehead, Beth A Dombroski, Derek Van Booven, Rosalyn Lang, Derek M Dykxhoorn, Lindsay A Farrer, Michael L Cuccaro, Jeffery M Vance, John R Gilbert, Gary W Beecham, Eden R Martin, Regina M Carney, Richard Mayeux, Gerard D Schellenberg, Goldie S Byrd, Jonathan L Haines, Margaret A Pericak-Vance
OBJECTIVE: To identify a causative variant(s) that may contribute to Alzheimer disease (AD) in African Americans (AA) in the ATP-binding cassette, subfamily A (ABC1), member 7 (ABCA7) gene, a known risk factor for late-onset AD. METHODS: Custom capture sequencing was performed on ∼150 kb encompassing ABCA7 in 40 AA cases and 37 AA controls carrying the AA risk allele (rs115550680). Association testing was performed for an ABCA7 deletion identified in large AA data sets (discovery n = 1,068; replication n = 1,749) and whole exome sequencing of Caribbean Hispanic (CH) AD families...
June 2016: Neurology. Genetics
Shea J Andrews, Debjani Das, Nicolas Cherbuin, Kaarin J Anstey, Simon Easteal
We examined the association of 28 single nucleotide polymorphisms (SNPs), previously associated with dementia or cognitive performance, with tests assessing episodic memory, working memory, vocabulary, and perceptual speed in 1689 nondemented older Australians of European ancestry. In addition to testing each variant individually, we assessed the collective association of the 12-risk SNPs for late-onset Alzheimer's disease using weighted and unweighted genetic risk scores. Significant associations with cognitive performance were observed for APOE ε4 allele, ABCA7-rs3764650, CR1-rs3818361, MS4A4E-rs6109332, BDNF-rs6265, COMT-rs4680, CTNNBL-rs6125962, FRMD4A-rs17314229, FRMD4A-rs17314229, intergenic SNP chrX-rs12007229, PDE7A-rs10808746, SORL1-rs668387, and ZNF224-rs3746319...
May 2016: Neurobiology of Aging
Karen Nuytemans, Lizmarie Maldonado, Aleena Ali, Krista John-Williams, Gary W Beecham, Eden Martin, William K Scott, Jeffery M Vance
OBJECTIVE: Given their reported function in phagocytosis and clearance of protein aggregates in Alzheimer disease (AD), we hypothesized that variants in ATP-binding cassette transporter A7 (ABCA7) might be involved in Parkinson disease (PD). METHODS: ABCA7 variants were identified using whole-exome sequencing (WES) on 396 unrelated patients with PD and 222 healthy controls. In addition, we used the publicly available WES data from the Parkinson's Progression Markers Initiative (444 patients and 153 healthy controls) as a second, independent data set...
February 2016: Neurology. Genetics
Andreas Lazaris, Kristy S Hwang, Naira Goukasian, Leslie M Ramirez, Jennifer Eastman, Anna E Blanken, Edmond Teng, Karen Gylys, Greg Cole, Andrew J Saykin, Leslie M Shaw, John Q Trojanowski, William J Jagust, Michael W Weiner, Liana G Apostolova
OBJECTIVE: We investigated the association between apoE protein plasma levels and brain amyloidosis and the effect of the top 10 Alzheimer disease (AD) risk genes on this association. METHODS: Our dataset consisted of 18 AD, 52 mild cognitive impairment, and 3 cognitively normal Alzheimer's Disease Neuroimaging Initiative 1 (ADNI1) participants with available [(11)C]-Pittsburgh compound B (PiB) and peripheral blood protein data. We used cortical pattern matching to study associations between plasma apoE and cortical PiB binding and the effect of carrier status for the top 10 AD risk genes...
October 2015: Neurology. Genetics
Tobi Van den Bossche, Kristel Sleegers, Elise Cuyvers, Sebastiaan Engelborghs, Anne Sieben, Arne De Roeck, Caroline Van Cauwenberghe, Steven Vermeulen, Marleen Van den Broeck, Annelies Laureys, Karin Peeters, Maria Mattheijssens, Mathieu Vandenbulcke, Rik Vandenberghe, Jean-Jacques Martin, Peter P De Deyn, Patrick Cras, Christine Van Broeckhoven
OBJECTIVE: To generate a clinical and pathologic phenotype of patients carrying rare loss-of-function mutations in ABCA7, identified in a Belgian Alzheimer patient cohort and in an autosomal dominant family. METHODS: We performed a retrospective review of available data records, medical records, results of CSF analyses and neuroimaging studies, and neuropathology data. RESULTS: The mean onset age of the mutation carriers (n = 22) was 73.4 ± 8...
June 7, 2016: Neurology
Russell H Swerdlow
No abstract text is available yet for this article.
June 7, 2016: Neurology
Kilan Le Guennec, Gaël Nicolas, Olivier Quenez, Camille Charbonnier, David Wallon, Céline Bellenguez, Benjamin Grenier-Boley, Stéphane Rousseau, Anne-Claire Richard, Anne Rovelet-Lecrux, Delphine Bacq, Jean-Guillaume Garnier, Robert Olaso, Anne Boland, Vincent Meyer, Jean-François Deleuze, Philippe Amouyel, Hans Markus Munter, Guillaume Bourque, Mark Lathrop, Thierry Frebourg, Richard Redon, Luc Letenneur, Jean-François Dartigues, Florence Pasquier, Adeline Rollin-Sillaire, Emmanuelle Génin, Jean-Charles Lambert, Didier Hannequin, Dominique Campion
OBJECTIVE: To study the association between ABCA7 rare coding variants and Alzheimer disease (AD) in a case-control setting. METHODS: We conducted a whole exome analysis among 484 French patients with early-onset AD and 590 ethnically matched controls. RESULTS: After collapsing rare variants (minor allele frequency ≤1%), we detected an enrichment of ABCA7 loss of function (LOF) and predicted damaging missense variants in cases (odds ratio [OR] 3...
June 7, 2016: Neurology
Nobutaka Sakae, Chia-Chen Liu, Mitsuru Shinohara, Jessica Frisch-Daiello, Li Ma, Yu Yamazaki, Masaya Tachibana, Linda Younkin, Aishe Kurti, Minerva M Carrasquillo, Fanggeng Zou, Daniel Sevlever, Gina Bisceglio, Ming Gan, Romain Fol, Patrick Knight, Miao Wang, Xianlin Han, John D Fryer, Michael L Fitzgerald, Yasumasa Ohyagi, Steven G Younkin, Guojun Bu, Takahisa Kanekiyo
UNLABELLED: In Alzheimer's disease (AD), the accumulation and deposition of amyloid-β (Aβ) peptides in the brain is a central event. Aβ is cleaved from amyloid precursor protein (APP) by β-secretase and γ-secretase mainly in neurons. Although mutations inAPP,PS1, orPS2cause early-onset familial AD,ABCA7encoding ATP-binding cassette transporter A7 is one of the susceptibility genes for late-onset AD (LOAD), in which itsloss-of-functionvariants increase the disease risk. ABCA7 is homologous to a major lipid transporter ABCA1 and is highly expressed in neurons and microglia in the brain...
March 30, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Jasmine Nettiksimmons, Gregory Tranah, Daniel S Evans, Jennifer S Yokoyama, Kristine Yaffe
Single nucleotide polymorphisms (SNPs) in and near ABCA7, BIN1, CASS4, CD2AP, CD33, CELF1, CLU, complement receptor 1 (CR1), EPHA1, EXOC3L2, FERMT2, HLA cluster (DRB5-DQA), INPP5D, MEF2C, MS4A cluster (MS4A3-MS4A6E), NME8, PICALM, PTK2B, SLC24A4, SORL1, and ZCWPW1 have been associated with Alzheimer's disease (AD) in large meta-analyses. We aimed to determine whether established AD-associated genes are associated with longitudinal cognitive decline by examining aggregate variation across these gene regions...
April 2016: Age (2005-)
Qing-Fei Zhao, Yu Wan, Hui-Fu Wang, Fu-Rong Sun, Xiao-Ke Hao, Meng-Shan Tan, Chen-Chen Tan, Dao-Qiang Zhang, Lan Tan, Jin-Tai Yu
ABCA7 gene has been identified as a strong genetic locus for Alzheimer's disease (AD) susceptibility in genome wide association studies (GWAS). However, the possible roles of ABCA7 variants in AD pathology were not specifically assessed. Using tagger methods, we extracted 15 targeted ABCA7 loci to investigate their associations with cerebrospinal fluid (CSF) and neuroimaging markers in Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset. Finally, although we did not detect any significant associations of previously published GWAS SNPs (rs3764650 and rs78117248) with all the CSF (Aβ1 - 42, T-tau, and P-tau) and neuroimaging markers, three other variants (rs3752242, rs3752240, and rs4147912) at ABCA7 loci were detected to show significant associations with amyloid deposition on AV-45 PET in brain...
March 21, 2016: Journal of Alzheimer's Disease: JAD
Jonathan M Schott, Sebastian J Crutch, Minerva M Carrasquillo, James Uphill, Tim J Shakespeare, Natalie S Ryan, Keir X Yong, Manja Lehmann, Nilufer Ertekin-Taner, Neill R Graff-Radford, Bradley F Boeve, Melissa E Murray, Qurat Ul Ain Khan, Ronald C Petersen, Dennis W Dickson, David S Knopman, Gil D Rabinovici, Bruce L Miller, Aida Suárez González, Eulogio Gil-Néciga, Julie S Snowden, Jenny Harris, Stuart M Pickering-Brown, Eva Louwersheimer, Wiesje M van der Flier, Philip Scheltens, Yolande A Pijnenburg, Douglas Galasko, Marie Sarazin, Bruno Dubois, Eloi Magnin, Daniela Galimberti, Elio Scarpini, Stefano F Cappa, John R Hodges, Glenda M Halliday, Lauren Bartley, Maria C Carrillo, Jose T Bras, John Hardy, Martin N Rossor, John Collinge, Nick C Fox, Simon Mead
INTRODUCTION: The genetics underlying posterior cortical atrophy (PCA), typically a rare variant of Alzheimer's disease (AD), remain uncertain. METHODS: We genotyped 302 PCA patients from 11 centers, calculated risk at 24 loci for AD/DLB and performed an exploratory genome-wide association study. RESULTS: We confirm that variation in/near APOE/TOMM40 (P = 6 × 10(-14)) alters PCA risk, but with smaller effect than for typical AD (PCA: odds ratio [OR] = 2...
August 2016: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
Jolanta Dorszewska, Michal Prendecki, Anna Oczkowska, Mateusz Dezor, Wojciech Kozubski
Alzheimer's disease (AD) is a multifactorial disease with genetic (70%) and environmental (30%) causes. Among the genetic factors are genes associated with a family history of the disease (familial AD, FAD) and sporadic AD (SAD). The genes: APP (amyloid precursor protein), PSEN1 (Presenilin 1) and PSEN2 (Presenilin 2) are responsible for the presence of FAD. The APOE gene is responsible for the sporadic form of the disease. Other molecular factors related to the immunological cause (TREM2) of the disease are a disorder of the lipid (ABCA1, ABCA7) or biothiol (MTHFD1) metabolism and of the transport of metabolites (BIN1)...
2016: Current Alzheimer Research
Leslie M Ramirez, Naira Goukasian, Shai Porat, Kristy S Hwang, Jennifer A Eastman, Sona Hurtz, Benjamin Wang, Nouchee Vang, Renee Sears, Eric Klein, Giovanni Coppola, Liana G Apostolova
The precise physiologic function of many of the recently discovered Alzheimer's disease risk variants remains unknown. The downstream effects of genetic variants remain largely unexplored. We studied the relationship between the top 10 non-APOE genes with cortical and hippocampal atrophy as markers of neurodegeneration using 1.5T magnetic resonance imaging, 1-million single nucleotide polymorphism Illumina Human Omni-Quad array and Illumina Human BeadChip peripheral blood expression array data on 50 cognitively normal and 98 mild cognitive impairment subjects...
March 2016: Neurobiology of Aging
Jie Bao, Xiao-jie Wang, Zong-fu Mao
BACKGROUND: Alzheimer disease (AD) has become an epidemic within the growing elderly population and effective therapies of AD have not been discovered. Genetic factors accounted for over 70% of the incidence of AD and the disease-related polymorphisms are located on chromosome 19, which is one of several prominent chromosomes related to the development of AD. Many inconsistent associations between polymorphisms in ABCA7, CD33, and TOMM40 genes and the susceptibility to AD have been suggested by several independent studies...
2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Hongyun Li, Tim Karl, Brett Garner
ATP-binding cassette transporter A7 (ABCA7) is highly expressed in the brain. Recent genome-wide association studies (GWAS) have identified ABCA7 single nucleotide polymorphisms (SNPs) that increase Alzheimer's disease (AD) risk, however, the mechanisms by which ABCA7 may control AD risk remain to be fully elucidated. Based on previous research suggesting that certain ABC transporters may play a role in the regulation of neurogenesis, we conducted a study of cell proliferation and neurogenic potential using cellular bromodeoxyuridine (BrdU) incorporation and doublecortin (DCX) immunostaining in adult Abca7 deficient mice and wild-type-like (WT) littermates...
2016: Bioscience Reports
Ya-qin Wang, Bei-sha Tang, Yang Yang, Yi-ting Cui, Ji-feng Kang, Zhen-hua Liu, Kai Li, Qi-ying Sun, Qian Xu, Xin-xiang Yan, Ji-feng Guo
Alzheimer's disease (AD), Parkinson's disease (PD), and cognitive impairment in PD have overlapping clinical and pathological features. To examine whether there is a genetic link for these diseases, we performed a case-control study in Chinese population to evaluate the association of AD genome-wide association studies top hits with both PD and cognitive function in PD, investigating 13 single-nucleotide polymorphisms in 9 genes (BIN1, CLU, ABCA7, CR1, PICALM, MS4A6A, CD33, MS4A4E, and CD2AP). A total of 454 controls and 442 PD patients were genotyped, including 75 mild cognitive impairment and 99 dementia...
March 2016: Neurobiology of Aging
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