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https://www.readbyqxmd.com/read/29875801/indications-for-liver-surgery-in-benign-tumours
#1
Margot Fodor, Florian Primavesi, Eva Braunwarth, Benno Cardini, Thomas Resch, Reto Bale, Daniel Putzer, Benjamin Henninger, Rupert Oberhuber, Manuel Maglione, Christian Margreiter, Stefan Schneeberger, Dietmar Öfner, Stefan Stättner
Background: Management of benign liver tumours (BLT) is still object of discussion. Uncertainty still exists about patient selection, details of management, indications for surgical intervention and potential surgery-related complications. The up-to-date strategies for management of the most common benign solid tumours are recapitulated in this article. In addition, recommendations concerning practical issues are presented. Methods: Available data from peer-reviewed publications associated with the major controversies concerning treatment strategies of solid BLT were selected through a PubMed literature search...
2018: European Surgery: ACA: Acta Chirurgica Austriaca
https://www.readbyqxmd.com/read/29865043/differentiation-of-malignant-liver-tumors-by-software-based-perfusion-quantification-with-dynamic-contrast-enhanced-ultrasound-dceus
#2
Dane Wildner, Barbara Schellhaas, Daniel Strack, Ruediger S Goertz, Lukas Pfeifer, Cornelia Fießler, Markus F Neurath, Deike Strobel
BACKGROUNDEnhancement patterns on contrast-enhanced ultrasound (CEUS) help to distinguish different liver tumors. OBJECTIVE: Assessing the diagnostic value of dynamic contrast-enhanced ultrasound (DCEUS) for the discrimination of different malignant liver lesions. METHODS: 148 malignant focal liver lesions were assessed prospectively with DCEUS (hepatocellular carcinoma = HCC; cholangiocellular carcinoma = CCC; pancreatic adenocarcinoma = PCA; breast cancer = BC; colorectal cancer = CRC; melanoma = MM)...
May 25, 2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29807039/large-scale-screening-of-circulating-micrornas-in-individuals-with-hiv-1-mono-infections-reveals-specific-liver-damage-signatures
#3
Sandra Franco, Daniela Buccione, Raquel Pluvinet, Beatriz Mothe, Lidia Ruiz, Maria Nevot, Ana Jordan-Paiz, Laia Ramos, Susanna Aussó, Rosa M Morillas, Lauro Sumoy, Miguel Angel Martinez, Cristina Tural
Human immunodeficiency virus type 1 (HIV-1)-induced inflammation and/or long-term antiretroviral drug toxicity may contribute to the evolution of liver disease. We investigated circulating plasma microRNAs (miRNAs) as potential biomarkers of liver injury in patients mono-infected with HIV-1. We performed large-scale deep sequencing analyses of small RNA level on plasma samples from patients with HIV-1 mono-infection that had elevated or normal levels of alanine aminotransferase (ALT) or focal nodular hyperplasia (FNH)...
May 25, 2018: Antiviral Research
https://www.readbyqxmd.com/read/29776159/fluctuating-nonlinear-hydrodynamics-of-flocking
#4
Sunil Kumar Yadav, Shankar P Das
Starting from a microscopic model, the continuum field theoretic description of the dynamics of a system of active ingredients or "particles" is presented. The equations of motion for the respective collective densities of mass and momentum follow exactly from that of a single element in the flock. The single-particle dynamics has noise and anomalous momentum dependence in its frictional terms. The equations for the collective densities are averaged over a local equilibrium distribution to obtain the corresponding coarse grained equations of fluctuating nonlinear hydrodynamics (FNH)...
March 2018: Physical Review. E
https://www.readbyqxmd.com/read/29744090/stepwise-management-of-hepatocellular-carcinoma-associated-with-abernethy-syndrome
#5
Niki Christou, Nabil Dib, Etienne Chuffart, Abdelkader Taibi, Sylvaine Durand-Fontanier, Denis Valleix, Muriel Mathonnet
Patients with congenital agenesis of the portal vein may develop hepatocellular tumors due to enhanced arterial blood flow. These tumors may be benign (FNH, adenomas) or malignant (hepatoblastoma, HCC). Liver resection can be proposed, and preoperative arterial embolization may decrease blood loss during surgery. Liver transplantation with PV reconstruction is also an option.
May 2018: Clinical Case Reports
https://www.readbyqxmd.com/read/29740826/can-point-shear-wave-elastography-differentiate-focal-nodular-hyperplasia-from-hepatocellular-adenoma
#6
Pavel Taimr, Anne Julia Klompenhouwer, Maarten G J Thomeer, Bettina E Hansen, Jan N M Ijzermans, Robert A de Man, Robert J de Knegt
PURPOSE: Focal nodular hyperplasia (FNH) and hepatocellular adenoma (HCA) are liver tumors that require different management. We assessed the potential of point shear wave elastography (pSWE) to differentiate FNH from HCA and the interobserver and intraobserver reliability of pSWE in the examination of these lesions and of native liver tissue (NLT). METHODS: The study included 88 patients (65 FNH, 23 HCA). pSWE was performed by two experienced liver sonographers (observers 1 [O1] and 2 [O2]) and acquired within the lesion of interest and NLT...
May 8, 2018: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/29721686/quantitative-correlation-between-uptake-of-gd-bopta-on-hepatobiliary-phase-and-tumor-molecular-features-in-patients-with-benign-hepatocellular-lesions
#7
Edouard Reizine, Giuliana Amaddeo, Frederic Pigneur, Laurence Baranes, François Legou, Sebastien Mulé, Benhalima Zegai, Vincent Roche, Alexis Laurent, Alain Rahmouni, Julien Calderaro, Alain Luciani
PURPOSE: The purpose of our study was to correlate the quantitative analysis of benign hepatocellular tumor uptake on delayed hepatobiliary phase (HBP) imaging with the quantitative level of OATP expression. METHODS: This single-center retrospective study, which took place between September 2009 and March 2015, included 20 consecutive patients with a proven pathologic and immunohistochemical (IHC) diagnosis of FNH or HCA, including quantification of the OATP expression...
May 2, 2018: European Radiology
https://www.readbyqxmd.com/read/29708786/differentiation-between-hepatocellular-carcinoma-showing-hyperintensity-on-the-hepatobiliary-phase-of-gadoxetic-acid-enhanced-mri-and-focal-nodular-hyperplasia-by-ct-and-mri
#8
Azusa Kitao, Osamu Matsui, Norihide Yoneda, Ryuichi Kita, Kazuto Kozaka, Satoshi Kobayashi, Toshifumi Gabata
OBJECTIVE: The purpose of this study is to identify points useful in the imaging differentiation of hepatocellular carcinoma (HCC) showing hyperintensity on the hepatobiliary phase of gadoxetic acid-enhanced MRI and focal nodular hyperplasia (FNH) and FNH-like nodules. MATERIALS AND METHODS: We enrolled consecutive 51 pathologically diagnosed HCCs that were hyperintense on hepatobiliary phase imaging (47 patients, including 44 with cirrhosis) and 10 FNHs and eight FNH-like nodules (16 patients, including five with cirrhosis)...
April 30, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29686569/pedunculated-focal-nodular-hyperplasia-in-a-healthy-toddler
#9
Juhi Koolwal, Krista L Birkemeier, Riyam T Zreik, Kelly D Mattix
Focal nodular hyperplasia (FNH) is a benign hepatic tumor rarely seen in pediatric patients, with most cases reported in school-aged children with a history of malignancy, liver disease, chemotherapy, or hematopoietic stem cell therapy. Despite having advanced radiographic imaging, diagnosing FNH before surgical resection can be difficult. We report a rare case of pedunculated FNH presenting as a large abdominal mass palpated on physical exam in a healthy 3-year-old girl with no history of malignancy or underlying liver disease...
January 2018: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/29492364/spontaneous-rupture-of-a-hepatic-adenoma-diagnostic-nuances-and-the-necessity-of-followup
#10
Preston F Ashby, Chelsea Alfafara, Albert Amini, Richard Amini
We present the case of a young female on oral contraceptives (OCs) who was diagnosed with focal nodular hyperplasia (FNH) and remained on oral contraceptives. Months later, the patient presented with acute abdominal pain and intratumoral hemorrhage in the liver. The patient was taken to the operating room (OR) and was diagnosed with a ruptured hepatic adenoma (HA). We review the key diagnostic features of FNH and HA, the different management guidelines including use of OCs, and potential surgical indications...
December 20, 2017: Curēus
https://www.readbyqxmd.com/read/29427046/hepatobiliary-phase-liver-mr-imaging-findings-after-oxaliplatin-based-chemotherapy-in-cancer-patients
#11
REVIEW
Emre Ünal, Ali Devrim Karaosmanoğlu, Mustafa Nasuh Ozmen, Deniz Akata, Musturay Karcaaltincaba
OBJECTIVE: To describe Gd-EOB-DTPA-enhanced liver MR imaging findings in colon and rectal cancer patients who received Oxaliplatin. CONCLUSION: Spectrum of hepatobiliary phase imaging findings include diffuse heterogeneous dysfunction, macronodular and micronodular FNH-like lesions, and coexistence of periportal increased liver function with FNH-like lesions. Differentiation of these benign lesions from metastasis is crucial to avoid biopsy in patients with colorectal cancers and may allow better understanding of sinusoidal obstruction syndrome pathophysiology and regenerative response of liver...
February 9, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29334905/efficacy-comparison-of-multi-phase-ct-and-hepatotropic-contrast-enhanced-mri-in-the-differential-diagnosis-of-focal-nodular-hyperplasia-a-prospective-cohort-study
#12
Tomasz K Nowicki, Karolina Markiet, Ewa Izycka-Swieszewska, Katarzyna Dziadziuszko, Michal Studniarek, Edyta Szurowska
BACKGROUND: Different clinical behaviour influences the importance of differentiating focal nodular hyperplasia (FNH) from other focal liver lesions (FLLs). The aim of this study was to compare the efficacy of contrast-enhanced CT and MRI in the diagnosis of FNH. METHODS: 157 patients with equivocal FLLs detected in ultrasonography subsequently underwent multi-phase CT and MRI with the use of hepatotropic contrast agent (Gd-BOPTA) in a 1.5 T scanner. Examinations were evaluated by three independent readers...
January 15, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29323545/focal-nodular-hyperplasia-after-treatment-with-oxaliplatin-a-multiinstitutional-series-of-cases-diagnosed-at-mri
#13
Alessandro Furlan, Giuseppe Brancatelli, Marco Dioguardi Burgio, Luigi Grazioli, Jeong Min Lee, Elena Murmura, Olivier Lucidarme, Christiane Strauss, Agnes Rode, Maxime Ronot, Valerie Vilgrain
OBJECTIVE: Benign hepatic lesions may occur after chemotherapy treatment and may mimic metastases at imaging. We describe focal nodular hyperplasia (FNH) lesions diagnosed at MRI that occurred de novo after treatment with oxaliplatin. MATERIALS AND METHODS: This is a multiinstitutional case series. We report 14 adult patients with cancer (eight men and six women) with a history of treatment with oxaliplatin and development of new hepatic lesions diagnosed as FNH at pathologic analysis or MRI or both...
April 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29277753/managing-focal-nodular-hyperplasia-of-the-liver-surgery-or-minimally-invasive-approaches-a-review-of-the-preferable-treatment-options
#14
REVIEW
Edoardo Virgilio, Marco Cavallini
BACKGROUND/AIM: Focal nodular hyperplasia (FNH) is the second most common benign tumor of the liver. As of 2017, many clinical, radiological and surgical features have been largely documented. On the other hand, little is still known about the correlation of FNH with hepatocellular carcinoma, nor the preferable modality of treatment. Our aim was to elucidate the latter topic. MATERIALS AND METHODS: We investigated the pertinent literature available as of 2017 through four popular search engines (PubMed, Science Direct, Scopus and Google Scholar)...
January 2018: Anticancer Research
https://www.readbyqxmd.com/read/29230554/correction-to-differentiating-focal-nodular-hyperplasia-from-hepatocellular-adenoma-is-hepatobiliary-phase-mri-hbp-mri-using-linear-gadolinium-chelates-always-useful
#15
Marion Roux, Frederic Pigneur, Laurence Baranes, Julien Calderaro, Mélanie Chiaradia, Thomas Decaens, Sandrine Kastahian, Anaïs Charles-Nelson, Lambros Tselikas, Charlotte Costentin, Alexis Laurent, Daniel Azoulay, Ariane Mallat, Alain Rahmouni, Alain Luciani
The original version of this article unfortunately contained a mistake. There was an error in the last sentence of the summary and the last sentence of the discussion. It should read as "On HBP, all FNH appeared hyper- or iso-intense compared to adjacent liver while close to 97% of HCA appeared hypointense".
December 11, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/29209117/application-of-superb-microvascular-imaging-in-focal-liver-lesions
#16
Meng-Na He, Ke Lv, Yu-Xin Jiang, Tian-An Jiang
AIM: To explore the ability of superb microvascular imaging (SMI) in differential diagnosis of focal liver lesions (FLLs) and to compare SMI morphology findings to those of color Doppler ultrasound and enhanced imaging. METHODS: Twenty-four patients with 31 FLLs were included in our study, with diagnoses of hemangioma (HE) ( n = 17), hepatocellular carcinoma (HCC) ( n = 5), metastatic lesions ( n = 5), primary hepatic lymphoma ( n = 1), focal nodular hyperplasia (FNH) ( n = 2), and adenoma ( n = 1)...
November 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29190518/multiple-focal-nodular-hyperplasia-mri-features
#17
Kiran K Busireddy, Miguel Ramalho, Mamdoh AlObaidy, António P Matos, Lauren M Burke, Brian M Dale, Richard C Semelka
PURPOSE: To describe MRI features of multiple Focal Nodular Hyperplasia (FNHs). METHODS: 40 consecutive subjects (37 females, mean age, 38.8years) were included. All studies were independently reviewed. This was an observational study to define the radiological features of multifocal FNH. RESULTS: 130 lesions were evaluated. The majority (88.5%), were peripheral in location. 92.3% lesions were lobulated. Marked enhancement was present in 94...
November 24, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/29167952/growth-of-focal-nodular-hyperplasia-is-not-a-reason-for-surgical-intervention-but-patients-should-be-referred-to-a-tertiary-referral-centre
#18
Mirelle E E Bröker, Anne J Klompenhouwer, Marcia P Gaspersz, Annick M E Alleleyn, Roy S Dwarkasing, Indra C Pieters, Robert A de Man, Jan N M IJzermans
BACKGROUND: When a liver lesion diagnosed as focal nodular hyperplasia (FNH) increases in size, it may cause doubt about the initial diagnosis. In many cases, additional investigations will follow to exclude hepatocellular adenoma or malignancy. This retrospective cohort study addresses the implications of growth of FNH for clinical management. METHODS: We included patients diagnosed with FNH based on ≥2 imaging modalities between 2002 and 2015. Characteristics of patients with growing FNH with sequential imaging in a 6-month interval were compared to non-growing FNH...
May 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29131270/imaging-assessment-of-portal-venous-system-pictorial-essay-of-normal-anatomy-anatomic-variants-and-congenital-anomalies
#19
A Guerra, A M De Gaetano, A Infante, C Mele, M G Marini, E Rinninella, R Inchingolo, L Bonomo
The purpose of this pictorial essay is to describe anatomic variants and congenital anomalies of portal venous system and related liver parenchymal alterations. The imaging findings of some of these entities have been previously described in other articles, however this work encompasses all congenital anomalies of portal venous system with attention to their features on various imaging modalities; in particular we illustrated with detailed pictures all the main portal vein variants, congenital extra- and intra-hepatic porto-systemic venous shunts and portal vein aneurysm...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29127141/copper-deposition-in-focal-nodular-hyperplasia-and-inflammatory-hepatocellular-adenoma
#20
Vishal S Chandan, Sejal S Shah, Taofic Mounajjed, Michael S Torbenson, Tsung-Teh Wu
AIMS: To examine copper deposition in focal nodular hyperplasia (FNH) and inflammatory hepatocellular adenoma (IHA) and to determine if it can play a role in their differentiation. METHODS: 28 FNHs and 19 IHAs from surgical resections showing typical morphological and immunohistochemical features were stained with rhodanine to evaluate for copper deposition. Histological features such as nodularity, fibrous bands, ductular proliferation, steatosis, ballooned hepatocytes and lymphocytic inflammation were also scored...
November 10, 2017: Journal of Clinical Pathology
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