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https://www.readbyqxmd.com/read/27910813/transarterial-embolization-with-bleomycin-for-symptomatic-hepatic-focal-nodular-hyperplasia
#1
Guodong Zhang, Maoqiang Wang, Feng Duan, Kai Yuan, Kai Li, Jieyu Yan, Zhongfei Chang
PURPOSE: We aimed to evaluate the therapeutic effect and safety of transarterial embolization using bleomycin-iodinated oil and polyvinyl alcohol particles for the treatment of symptomatic hepatic focal nodular hyperplasia (FNH). METHODS: This retrospective study included 23 consecutive patients with symptomatic hepatic FNH, who underwent embolization using bleomycin-iodinated oil and polyvinyl alcohol particles between January 2005 and December 2012. Patients were followed-up with radiologic and clinical evaluation...
December 2, 2016: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/27903597/impact-of-organic-cation-transporters-oct-slc22a-on-differential-diagnosis-of-intrahepatic-lesions
#2
Michele Visentin, Belle V van Rosmalen, Christian Hiller, Matthanja Bieze, Lia Hofstetter, Joanne Verheij, Gerd A Kullak-Ublick, Hermann Koepsell, Saffire Sks Phoa, Ikumi Tamai, Roelof J Bennink, Thomas M van Gulik, Bruno Stieger
Positron emission tomography (PET) using the cationic compound [(18)F]fluoromethylcholine (FCH) enhances the sensitivity for non-invasive classification of hepatic tumours due to peculiar patterns of accumulation. The underlying transporters are not known. We aim to identify the carriers mediating uptake of FCH in liver and to correlate their expression pattern with PET intrahepatic signal distribution to clarify the role of membrane transporters in FCH accumulation. FCH transport was characterized in cells overexpressing organic cation transporters (OCTs)...
November 30, 2016: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/27825058/huge-focal-nodular-hyperplasia-presenting-in-a-6-year-old-child-a-case-presentation
#3
Lin Zhuang, Chuangye Ni, Wenbing Din, Feng Zhang, Yi Zhuang, Yawei Sun, Dong Xi
INTRODUCTION: Focal nodular hyperplasia (FNH) is a benign lesion of the liver which is usually found in healthy adults, however, FNH is rare in children, and comprises only 2% of all pediatric liver tumors. Herein, we report the case of a 6-year-old child (male) with a huge FNH which size is more than 10cm. This could be the biggest FNH among all children's FNH cases ever reported. CASE PRESENTATION: A 6-year-old boy was found a hepatic space-occupying lesion two years ago...
October 27, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27776663/superb-microvascular-imaging-technology-for-ultrasound-examinations-initial-experiences-for-hepatic-tumors
#4
Dong Ho Lee, Jae Young Lee, Joon Koo Han
PURPOSE: To explore whether superb microvascular imaging (SMI) technology could be helpful for the evaluation of hepatic tumors. MATERIALS AND METHODS: Our institutional review board approved this study, and informed consent was obtained from all of the patients. Twenty-three patients with 29 hepatic tumors were enrolled in our study. The tumors consisted of hemangiomas (n=15), focal nodular hyperplasias (FNHs) (n=7), and hepatocellular carcinomas (n=7). All lesions were pathologically (n=2) or radiologically (n=27) confirmed...
November 2016: European Journal of Radiology
https://www.readbyqxmd.com/read/27740898/benign-hepatocellular-nodules-hepatobiliary-phase-of-gadoxetic-acid-enhanced-mr-imaging-based-on-molecular-background
#5
Norihide Yoneda, Osamu Matsui, Azusa Kitao, Kazuto Kozaka, Satoshi Kobayashi, Motoko Sasaki, Kotaro Yoshida, Dai Inoue, Tetsuya Minami, Toshifumi Gabata
Gadoxetic acid is a contrast agent for magnetic resonance (MR) imaging with hepatocyte-specific properties and is becoming increasingly important in detection and characterization of hepatocellular carcinoma and benign hepatocellular nodules, including focal nodular hyperplasia (FNH), nodular regenerative hyperplasia (NRH), hepatocellular adenoma (HCA), and dysplastic nodule. In these hepatocellular nodules, a positive correlation between the grade of membranous uptake transporter organic anion-transporting polypeptide (OATP) 1B3 expression and signal intensity in the hepatobiliary (HB) phase has been verified...
October 14, 2016: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/27734153/burden-of-chemotherapy-induced-febrile-neutropenia-hospitalizations-in-us-clinical-practice-by-use-and-patterns-of-prophylaxis-with-colony-stimulating-factor
#6
Derek Weycker, Xiaoyan Li, Spiros Tzivelekis, Mark Atwood, Jacob Garcia, Yanli Li, Maureen Reiner, Gary H Lyman
INTRODUCTION: Evidence suggests that many cancer chemotherapy patients who are candidates for colony-stimulating factor (CSF) prophylaxis do not receive it or receive it inconsistent with guidelines, and that such patients have a higher risk of febrile neutropenia hospitalization (FNH). Little is known about the number and consequences of FNH by use/patterns of CSF prophylaxis in US clinical practice. METHODS: A retrospective cohort design and private healthcare claims data were employed...
October 12, 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/27726242/washout-appearance-in-gd-eob-dtpa-enhanced-mr-imaging-a-differentiating-feature-between-hepatocellular-carcinoma-with-paradoxical-uptake-on-the-hepatobiliary-phase-and-focal-nodular-hyperplasia-like-nodules
#7
Jeong Woo Kim, Chang Hee Lee, Soo Byn Kim, Bit Na Park, Yang Shin Park, Jongmee Lee, Cheol Min Park
PURPOSE: To identify the most reliable imaging features for differentiating hepatocellular carcinoma with paradoxical uptake on the hepatobiliary phase (HCCpara ) from focal nodular hyperplasia (FNH)-like nodules using Gd-EOB-DTPA-enhanced MRI. MATERIALS AND METHODS: This was a retrospective study. Twenty patients with HCCpara and 21 patients with FNH-like nodules were included. The following MRI features were evaluated using 3.0 Tesla unit by two radiologists: signal intensity (SI) on T1-, T2-, and diffusion-weighted imaging (DWI), arterial enhancement pattern, washout appearance on the portal venous phase (PVP) and/or transitional phase (TP), uptake pattern on the hepatobiliary phase (HBP), "T2 scar," "EOB scar," and chemical shift on in- and out-of-phase images...
October 11, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27708485/dwi-adc-in-differentiation-of-benign-from-malignant-focal-liver-lesion
#8
Elma Jahic, Amela Sofic, Azra Husic Selimovic
MATERIAL AND METHODS: The study was of prospective-retrospective character. It was carried out at the AKH in Vienna (Austria), where 100 patients with focal liver lesions were included in the study. All patients underwent the routine MR sequences on appliances 1,5 and 3T (Siemens, Germany): T1, T2, HASTE, VIBE, and a DWI with three b values (b 50, b 300 b 600 s / mm(2)) and ADC map with ROI (regions of interest). The numerical value of ADC map was calculated, where n = 100 liver lesions, by two independent radiologists...
July 16, 2016: Acta Informatica Medica: AIM
https://www.readbyqxmd.com/read/27704147/impact-of-hepatobiliary-phase-liver-mri-versus-contrast-enhanced-ultrasound-after-an-inconclusive-extracellular-gadolinium-based-contrast-enhanced-mri-for-the-diagnosis-of-benign-hepatocellular-tumors
#9
Lambros Tselikas, Frederic Pigneur, Marion Roux, Laurence Baranes, Charlotte Costentin, Vincent Roche, Julien Calderaro, Edouard Herin, Alexis Laurent, Elie Zafrani, Daniel Azoulay, Ariane Mallat, Alain Rahmouni, Alain Luciani
PURPOSE: To compare the added values of hepatobiliary phase (HBP) MRI and contrast-enhanced ultrasound (CEUS) in addition to inconclusive extracellular gadolinium-based contrast-enhanced MRI (CE-MRI) to characterize benign hepatocellular tumors (BHT). METHODS: Eighty-three BHT-46 focal nodular hyperplasia (FNH) and 37 hepatocellular adenomas (HCA)-with inconclusive CE-MRI in 54 patients (43 women and 11 men, mean age 42 years old ± 14.8) were retrospectively analyzed...
October 4, 2016: Abdominal Radiology
https://www.readbyqxmd.com/read/27578988/evaluation-of-the-characteristics-of-hepatic-focal-nodular-hyperplasia-correlation-between-dynamic-contrast-enhanced-multislice-computed-tomography-and-pathological-findings
#10
Hai-Tao Zhang, Xin-Yi Gao, Qin-Sha Xu, Yu-Tang Chen, Yu-Piao Song, Zhen-Wei Yao
OBJECTIVE: To evaluate the characteristics of enhancement of focal nodular hyperplasia (FNH) of the liver by analyzing the dynamic contrast-enhanced multislice computed tomography (MSCT) features and correlating them with pathological findings. PATIENTS AND METHODS: Nine males and 16 females with pathologically confirmed FNH and complete preoperative contrast-enhanced MSCT data were recruited for this study. The imaging features of FNH on the pre- and postcontrast MSCT were analyzed by two experienced radiologists by consensus...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27553837/long-term-outcomes-of-resection-in-patients-with-symptomatic-benign-liver-tumours
#11
Belle V van Rosmalen, Matthanja Bieze, Marc G H Besselink, Pieter Tanis, Joanne Verheij, Saffire S K S Phoa, Olivier Busch, Thomas M van Gulik
BACKGROUND: Benign liver tumours (e.g., hepatocellular adenoma (HCA), focal nodular hyperplasia (FNH), and haemangioma) are occasionally resected for alleged symptoms, although data on long-term outcomes is lacking. The aim of this cross-sectional study was to assess long-term outcomes of surgical intervention. METHODS: Forty patients with benign tumours (HCA 20, FNH 12, giant haemangioma 4, cysts 4) were included. Patients filled in Validated McGill Pain Questionnaires, preoperatively and after a median of 54 months after resection...
August 20, 2016: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/27550510/focal-nodular-hyperplasia-our-experience-of-53-japanese-cases
#12
Hiroko Naganuma, Hideaki Ishida, Masahiro Ogawa, Yukinobu Watanabe, Daisuke Watanabe, Yoko Ohyama, Takako Watanabe
PURPOSE: Contrast-enhanced ultrasound (CEUS) is a very sensitive diagnostic tool in characterizing liver tumors. It is especially useful in the diagnosis of focal nodular hyperplasia (FNH) of the liver. According to the previous reports, FNH is common in young women, and it is usually diagnosed by MRI. The majority of the previous reports come from European countries, and a very few studies of large series designed to describe the clinical features in Japanese patients have been reported...
August 22, 2016: Journal of Medical Ultrasonics
https://www.readbyqxmd.com/read/27526937/mri-of-paediatric-liver-tumours-how-we-review-and-report
#13
REVIEW
Susan C Shelmerdine, Derek J Roebuck, Alexander J Towbin, Kieran McHugh
Liver tumours are fortunately rare in children. Benign tumours such as haemangiomas and cystic mesenchymal hamartomas are typically seen in infancy, often before 6 months of age. After that age, malignant hepatic tumours increase in frequency. The differentiation of a malignant from benign lesion on imaging can often negate the need for biopsy. Ultrasound is currently the main screening tool for suspected liver pathology, and is ideally suited for evaluation of hepatic lesions in children due to their generally small size...
August 15, 2016: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
https://www.readbyqxmd.com/read/27519945/imaging-characteristics-of-focal-splenic-and-hepatic-lesions-in-type-1-gaucher-disease
#14
Martine Regenboog, Anneloes E Bohte, Inne Somers, Otto M van Delden, Mario Maas, Carla E M Hollak
In Gaucher disease (GD) imaging of liver and spleen is part of routine follow-up of GD patients. Focal lesions in both liver and spleen are frequently reported at radiological examinations. These lesions often represent benign accumulations of Gaucher cells, so-called "gaucheroma", but malignancies, especially hepatocellular carcinoma, are more frequently found in GD as well. We report the imaging characteristics of all focal lesions in liver and spleen in the Dutch GD cohort. Of the 95 GD1 patients, 40% had focal splenic and/or hepatic lesions, associated with more severe GD...
September 2016: Blood Cells, Molecules & Diseases
https://www.readbyqxmd.com/read/27383300/an-update-on-clinical-applications-of-hepatospecific-contrast-media-in-magnetic-resonance-imaging-of-liver-parenchyma
#15
M Giuga, A M De Gaetano, A Guerra, A Infante, R Iezzi, I Spinelli, M Siciliano, A Grieco, G L Rapaccini, A Gasbarrini, M Pompili, L Bonomo
Hepatobiliary-specific contrast agents are now widely used in magnetic resonance imaging (MRI) of liver parenchyma. As extracellular fluid agents, they provide informations regarding lesion vascularity and their use in the hepatobiliary or delayed phase (DPI), and give additional data regarding hepatocyte presence and function. The aim of this article is to review the recent literature about MRI using hepatobiliary-specific contrast agents and to discuss benefits and limits of their clinical applications. Since November 2008, hepatobiliary contrast agents were routinely employed in our Institution for the characterization of equivocal liver lesions detected by other imaging modalities, and for the evaluation of hepatic nodules in liver cirrhosis...
June 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27276915/markers-of-hippo-pathway-activity-in-tumor-forming-liver-lesions
#16
Henning Reis, Stefanie Bertram, Leona Pott, Ali Canbay, Anja Gallinat, Hideo Andreas Baba
Hepatocellular Carcinoma (HCC) is a lethal cancer worldwide. Recently, the hippo signaling pathway has been implicated in tumorigenesis of HCC and other malignant tumors. Aim of the study was therefore to evaluate the hippo signaling pathway activity and its clinico-pathological associations and crosstalk in different tumor forming hepatocellular lesions (HCC, hepatocellular adenoma (HCA), focal nodular hyperplasia (FNH) and cirrhosis). A tissue micro array (TMA) from paired human tumorous and non-tumorous (NT) tissue samples of HCC (n = 92), HCA (n = 25), FNH (n = 28) and cirrhosis (n = 28; no NT) was constructed...
June 8, 2016: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/27272806/incidentally-detected-focal-liver-lesions-a-common-clinical-management-dilemma-revisited
#17
Alexander Semaan, Vittorio Branchi, Anna-Lena Marowsky, Martin VON Websky, Patrick Kupczyk, Simon Jonas Enkirch, Guido Kukuk, Edwin Bölke, Burkhard Stoffels, Jörg C Kalff, Nico Schäfer, Philipp Lingohr, Hanno Matthaei
BACKGROUND: Detection of asymptomatic focal liver lesions (FLL) is increasing because of a widespread use of modern radiologic imaging. Most of these lesions are benign, though malignancy often has to be ruled out, which is posing a diagnostic challenge. AIM: To critically evaluate our treatment strategy in the context of recently published American College of Gastroenterology (ACG) guidelines. PATIENTS AND METHODS: The medical records of patients who underwent surgery for asymptomatic, incidentally detected FLL from 2005-2012 were reviewed...
June 2016: Anticancer Research
https://www.readbyqxmd.com/read/27247379/glutamine-synthetase-immunoreactivity-in-peritumoral-hyperplasia-in-liver-%C3%A2-case-report-of-a-metastatic-paraganglioma-with-focal-nodular-hyperplasia-like-changes-and-review-of-an-additional-54-liver-masses
#18
Bronwyn H Bryant, Maryam J Zenali, Paul E Swanson, Melissa P Upton, Matthew M Yeh, Carlos Cuevas, James O Park, Maria Westerhoff
OBJECTIVES: Focal nodular hyperplasia (FNH) and peritumoral hyperplasia in the liver exhibit increased immunoreactivity for glutamine synthetase (GS). We observed FNH-like changes with map-like GS staining surrounding a metastatic paraganglioma and sought to determine how often such changes occur around primary and metastatic liver lesions. METHODS: We performed GS immunohistochemistry in liver cases of 20 metastatic neuroendocrine carcinomas (NECs), 21 metastatic colon carcinomas (CCs), seven hepatocellular carcinomas (HCCs), and six FNHs and assessed lesions for size, degree of fibrosis (scored 1-3), and peritumoral hyperplasia...
August 2016: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/27235876/ivim-diffusion-mri-for-the-differentiation-of-solid-benign-and-malign-hypervascular-liver-lesions-evaluation-with-two-different-mr-scanners
#19
Miriam Klauss, Philipp Mayer, Klaus Maier-Hein, Frederik B Laun, Arineb Mehrabi, Hans-Ulrich Kauczor, Bram Stieltjes
PURPOSE: Hepatocellular carcinoma (HCC) and focal nodular hyperplasia (FNH) as the most common malign and benign liver tumors are both hypervascularized and potentially difficult to differentiate. DWI in liver MRI has been shown to be helpful in the classification of liver lesions, although with a substantial ADC-values-overlap. First results suggest that IVIM allows for improved characterization of liver lesions. In this study we evaluated IVIM-derived parameters in HCC and FNH with two different MR-scanners...
July 2016: European Journal of Radiology
https://www.readbyqxmd.com/read/27193796/optimal-visualization-of-focal-nodular-hyperplasia-quantitative-and-qualitative-evaluation-of-single-and-multiphasic-arterial-phase-acquisition-at-1-5%C3%A2-t-mr-imaging
#20
Caroline Rousseau, Maxime Ronot, Valérie Vilgrain, Marc Zins
PURPOSE: To evaluate the qualitative and quantitative benefit of multiple arterial phase acquisitions for the depiction of hypervascularity in FNH explored MR imaging using an extracellular contrast agent. METHODS: Between 2007 and 2014, all patients who underwent MR imaging for the exploration of FNH were included. The protocol included a single or a triple arterial phase ("single" and "triple" group, respectively). Arterial phases were visually divided into four types: (1) angiographic, (2) early, (3) late, and (4) portal...
May 2016: Abdominal Radiology
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