Read by QxMD icon Read

Hepatic adenoma

Thomas Gilliland, Sylvie Dufour, Gerald I Shulman, Kitt Falk Petersen, Sukru H Emre
NAFLD is a common condition linked to obesity, type 2 diabetes, and metabolic syndrome. Simple hepatic steatosis is a risk factor for inflammatory reactions in the liver (NASH), which may lead to cirrhosis. While the mechanism is unclear, NAFLD and NASH are associated with panhypopituitarism, which in the pediatric population often results from craniopharyngioma or pituitary adenoma and the sequelae of treatment, causing hypothyroidism, adrenal insufficiency, hypogonadotropic hypogonadism, and GH deficiency...
October 20, 2016: Pediatric Transplantation
Gavin Low, Harini Dharmana, Samantha Saravana-Bawan, Safwat Girgis
History An asymptomatic 33-year-old woman was referred to the Hepatology Department in 2013 for work-up of indeterminate multifocal liver masses. These lesions were discovered incidentally at multiphase contrast material-enhanced multidetector computed tomography (CT) performed in 2004 to investigate right lower quadrant pain. Imaging surveillance at sporadic intervals revealed slow progressive growth of the lesions over time; however, the number of lesions remained constant. There was no history of cancer, nor were there predisposing factors for chronic liver disease or cirrhosis...
November 2016: Radiology
Michael Devos, Barbara Gilbert, Geertrui Denecker, Kirsten Leurs, Conor Mc Guire, Kelly Lemeire, Tino Hochepied, Marnik Vuylsteke, Jo Lambert, Caroline Van Den Broecke, Louis Libbrecht, Jody Haigh, Geert Berx, Saskia Lippens, Peter Vandenabeele, Wim Declercq
Unlike its family member p53, the p63 gene is rarely mutated in human cancer. However, ΔNp63α protein levels are often elevated in tumors of epithelial origin, such as squamous cell carcinoma and cholangiocarcinoma. In order to study the oncogenic properties of ΔNp63α in vivo, we generated transgenic mice overexpressing ΔNp63α from the Rosa26 locus promoter controlled by K5Cre. We found that these mice spontaneously develop epidermal cysts and ectopic ΔNp63α expression in the bile duct epithelium that leads to dilatation of the intrahepatic biliary ducts, to hepatic cyst formation and bile duct adenoma...
October 7, 2016: Journal of Investigative Dermatology
Andrew B Rosenkrantz, Ankur M Doshi, Luke A Ginocchio, Yindalon Aphinyanaphongs
RATIONALE AND OBJECTIVES: This study aimed to assess the performance of a text classification machine-learning model in predicting highly cited articles within the recent radiological literature and to identify the model's most influential article features. MATERIALS AND METHODS: We downloaded from PubMed the title, abstract, and medical subject heading terms for 10,065 articles published in 25 general radiology journals in 2012 and 2013. Three machine-learning models were applied to predict the top 10% of included articles in terms of the number of citations to the article in 2014 (reflecting the 2-year time window in conventional impact factor calculations)...
September 27, 2016: Academic Radiology
B J Hughes, J Thomas, A M Lynch, S J Borghoff, S Green, T Mensing, S S Sarang, M J LeBaron
In a National Toxicology Program (NTP) chronic inhalation study with methyl isobutyl ketone (MIBK), increases in hepatocellular adenomas and hepatocellular adenomas and carcinomas (combined) were observed in male and female B6C3F1 mice at 1800 ppm. A DNA reactive Mode-of-Action (MOA) for this liver tumor response is not supported by the evidence as MIBK and its major metabolites lack genotoxicity in both in vitro and in vivo studies. Constitutive androstane receptor (CAR) nuclear receptor-mediated activation has been hypothesized as the MOA for MIBK-induced mouse liver tumorigenesis...
September 21, 2016: Regulatory Toxicology and Pharmacology: RTP
Mariko Kumagawa, Naoki Matsumoto, Yukinobu Watanabe, Midori Hirayama, Takao Miura, Hiroshi Nakagawara, Masahiro Ogawa, Shunichi Matsuoka, Mitsuhiko Moriyama, Tadatoshi Takayama, Masahiko Sugitani
Hepatocellular adenoma (HCA) was recently classified into four pathological subtypes. There have been few studies describing the findings of contrast-enhanced ultrasonography (CEUS) of each type. Our case concerns a 78-year-old man who had undergone routine medical check-ups for hepatitis C for 11 years. Abdominal ultrasonography showed a 28 mm, hypo-echoic mass in the segment 4 of the liver. His integrating amount of drinking was 670 kg convert into ethanol. CEUS with Sonazoid demonstrated mild uniform hypo-enhancement with inflow of microbubbles from the periphery of the tumor in the arterial phase, and heterogeneously hypo-enhancement in the post vascular phase...
September 18, 2016: World Journal of Hepatology
Dana L Shuey, Julian Oliver, Gongfu Zhou, Alan Roberts
Ruxolitinib is a selective and potent inhibitor of Janus kinase (JAK) 1 and JAK2. It is approved for the treatment of patients with intermediate or high-risk myelofibrosis, or those with polycythemia vera who have had an inadequate response to or are intolerant of hydroxyurea. To investigate its carcinogenic potential, ruxolitinib was administered by oral gavage once daily to Tg.rasH2 mice for 6 months at doses of 15, 45 or 125 mg/kg/day, and to Sprague-Dawley (Crl:CD) rats for 2 years at 10, 20 or 60 mg/kg/day...
September 16, 2016: Regulatory Toxicology and Pharmacology: RTP
Napat Angkathunyakul, Francesca Rosini, Nigel Heaton, Pierre Foskett, Alberto Quaglia
AIMS: Both homo- and heterozygous AAT deficiency patients are risk of hepatocellular carcinoma (HCC) but also of cholangiocarcinoma and combined hepatocellular-cholangiocarcinoma. We report a series of bile duct adenoma (BDA) and intrahepatic cholangiocarcinoma (ICC), in AAT deficiency adult patients, observed in our institution over a five year period. Our observational study includes a detailed investigation of their immunohistochemical profile and BRAF V600E mutation status. METHODS AND RESULTS: Eleven biliary lesions from 5 AAT deficiency patients (6 BDAs from 3 cirrhotic patients with concurrent other liver diseases, 3 BDAs and 2 ICCs from 2 non-cirrhotic patients) were identified between 2010 and 2015 during routine histology...
September 14, 2016: Histopathology
Alexis Laurent, Safi Dokmak, Jean-Charles Nault, François-René Pruvot, Jean-Michel Fabre, Christian Letoublon, Philippe Bachellier, Lorenzo Capussotti, Olivier Farges, Jean-Yves Mabrut, Yves-Patrice Le Treut, Ahmet Ayav, Bertrand Suc, Olivier Soubrane, Gilles Mentha, Irinel Popescu, Marco Montorsi, Nicolas Demartines, Jacques Belghiti, Guido Torzilli, Daniel Cherqui, Jean Hardwigsen
BACKGROUND: Hepatocellular adenoma (HCA) is a benign hepatic lesion that may be complicated by bleeding and malignant transformation. The aim of the present study is to report on large series of liver resections for HCA and assess the incidence of hemorrhage and malignant transformation. METHODS: A retrospective cross-sectional study, from 27 European high-volume HPB units. RESULTS: 573 patients were analyzed. The female: male gender ratio was 8:2, mean age: 37 ± 10 years...
September 2016: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
Jorge Hurtado-Cordovi, Ashley H Davis-Yadley, Seth Lipka, Magdalene Vardaros, Huafeng Shen
BACKGROUND: Limited knowledge exists about the effects chronic hepatitis C virus (HCV) infection has in the development of colorectal adenomas (CRA). Data regarding the association between chronic HIV infection and the development of CRA is scarce as well. We aim to determine if there is an association between the development of CRA and chronic infection with HCV and HCV/HIV co-infection. METHODS: From July 1, 2009 to March 31, 2011 a total of 2,051 patients that underwent colonoscopy were included in our study...
August 2016: Journal of Gastrointestinal Oncology
Susan C Shelmerdine, Derek J Roebuck, Alexander J Towbin, Kieran McHugh
Liver tumours are fortunately rare in children. Benign tumours such as haemangiomas and cystic mesenchymal hamartomas are typically seen in infancy, often before 6 months of age. After that age, malignant hepatic tumours increase in frequency. The differentiation of a malignant from benign lesion on imaging can often negate the need for biopsy. Ultrasound is currently the main screening tool for suspected liver pathology, and is ideally suited for evaluation of hepatic lesions in children due to their generally small size...
2016: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
L J Wang, Y M Zhang, Y L Deng, H Zheng, C Pan, Z Y Shen
OBJECTIVE: To analyse and explore the indications and efficacy of liver transplantation for benign liver tumor. METHODS: From Jan.2001 to Dec.2014, 6 patients, incluing 3 males and 3 females, with benign liver tumor underwent liver transplantation in our department.There were 2 cases of hepatic epithelioid hemangioendothelioma, 1 case of hepatic cavernous hemangioma, 1 case of liver mesenchymal hamartoma, 1 case of hilar bile duct mucinous cystadenoma, and 1 case of hepatic adenoma...
July 12, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Tetsuyuki Takahashi, Takeshi Nishida, Hayato Baba, Hideki Hatta, Johji Imura, Mitsuko Sutoh, Syunji Toyohara, Ryoji Hokao, Syunsuke Watanabe, Hirohisa Ogawa, Hisanori Uehara, Koichi Tsuneyama
We previously reported that Tsumura-Suzuki obese diabetic (TSOD) mice, a polygenic model of spontaneous type 2 diabetes, is a valuable model of hepatic carcinogenesis via non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). One of the characteristics of tumors in these mice is the diffuse expression of glutamine synthetase (GS), which is a diagnostic marker for hepatocellular carcinoma (HCC). In this study, we performed detailed histopathological examinations and found that GS expression was diffusely positive in >70% of the hepatic tumors from 15-month-old male TSOD mice...
August 2016: Molecular and Clinical Oncology
Andreu F Costa, Dilkash Kajal, André Pereira, Mostafa Atri
OBJECTIVES: To assess the significance of fat in the radiofrequency ablation (RFA) zone of hepatocellular adenomas (HCA), and its association with tumoral fat and hepatic steatosis. METHODS: The radiological archive was searched for patients with ablated HCAs and follow-up magnetic resonance imaging between January 2008 and June 2014. Age, sex, risk factors and duration of clinical and imaging follow-up were recorded. Pre-RFA imaging was assessed for tumour size, intra-tumoral fat and steatosis...
July 19, 2016: European Radiology
Christos G Tsokos, Gregor Krings, Funda Yilmaz, Linda D Ferrell, Ryan M Gill
Differentiation between benign and malignant lesions of the hepatic biliary tree may pose a diagnostic problem, as well-differentiated intrahepatic cholangiocarcinoma may mimic biliary hamartoma, bile duct adenoma, or parenchymal extinction. We evaluated Ki-67 proliferative index and p53 status by immunohistochemical staining to aid in exclusion of cholangiocarcinoma. 14 biliary hamartomas, 21 bile duct adenomas, and 11 livers with parenchymal extinction were compared to 26 intrahepatic cholangiocarcinomas (16 well-differentiated and 10 moderate- or poorly- differentiated tumors)...
July 7, 2016: Human Pathology
Wei Wang, Jin-Ya Liu, Zheng Yang, Yue-Feng Wang, Shun-Li Shen, Feng-Lian Yi, Yang Huang, Er-Jiao Xu, Xiao-Yan Xie, Ming-De Lu, Zhu Wang, Li-Da Chen
PURPOSE: To investigate and compare the contrast-enhanced ultrasound (CEUS) features of histologically proven HCA with those of contrast-enhanced computed tomography (CECT). METHODS: Eighteen patients with proven hepatic adenoma by pathology were retrospectively selected from the CEUS database. Fourteen of them had undergone liver CECT exams. The basic features on unenhanced imaging and the enhancement level and specific features on contrast-enhanced imaging were retrospectively analyzed, and the differences between CEUS and CECT were compared...
2016: SpringerPlus
M Giuga, A M De Gaetano, A Guerra, A Infante, R Iezzi, I Spinelli, M Siciliano, A Grieco, G L Rapaccini, A Gasbarrini, M Pompili, L Bonomo
Hepatobiliary-specific contrast agents are now widely used in magnetic resonance imaging (MRI) of liver parenchyma. As extracellular fluid agents, they provide informations regarding lesion vascularity and their use in the hepatobiliary or delayed phase (DPI), and give additional data regarding hepatocyte presence and function. The aim of this article is to review the recent literature about MRI using hepatobiliary-specific contrast agents and to discuss benefits and limits of their clinical applications. Since November 2008, hepatobiliary contrast agents were routinely employed in our Institution for the characterization of equivocal liver lesions detected by other imaging modalities, and for the evaluation of hepatic nodules in liver cirrhosis...
June 2016: European Review for Medical and Pharmacological Sciences
Peter Bond, William Llewellyn, Peter Van Mol
Anabolic androgenic steroids (AAS) have been abused for decades by both professional and amateur athletes in order to improve physical performance or muscle mass. AAS abuse can cause adverse effects, among which are hepatotoxic effects. These effects include cholestatic icterus and possibly peliosis hepatis and hepatocellular carcinoma or adenoma. In particular, 17α-alkylated AAS appear to be hepatotoxic, whereas nonalkylated AAS appear not to be. The 17α-alkyl substitution retards hepatic metabolism of the AAS rendering it orally bioavailable...
August 2016: Medical Hypotheses
Jesse T Young, Anil N Kurup, Rondell P Graham, Michael S Torbenson, Sudhakar K Venkatesh
PURPOSE: To describe the imaging appearance of myxoid hepatocellular neoplasms (MHNs), including adenomas and carcinomas, a recently described pathologically unique tumor variant. MATERIALS AND METHODS: Single-institution review of pathologically proven MHNs revealed 4 patients with imaging prior to resection. All available cross-sectional imaging was then retrospectively reviewed in consensus using specified descriptive characteristics previously published for hepatocellular adenoma subtypes...
June 22, 2016: Abdominal Radiology
Jennifer Mitchell, Peggy T Tinkey, Rony Avritscher, Carolyn Van Pelt, Ghazaleh Eskandari, Suraj Konnath George, Lianchun Xiao, Erik Cressman, Jeffrey S Morris, Asif Rashid, Ahmed O Kaseb, Hesham M Amin, Rajesh Uthamanthil
OBJECTIVE: The purpose of this study was to reduce the time to tumor onset in a diethylnitrosamine (DEN)-induced hepatocellular carcinoma (HCC) swine model via partial liver embolization (PLE) and to characterize the model for use in translational research. METHODS: Eight Yucatan miniature pigs were injected intraperitoneally with either saline (n = 2) or DEN (n = 6) solution weekly for 12 weeks. Three of the DEN-treated pigs underwent PLE. The animals underwent periodic radiological evaluation, liver biopsy, and blood sampling, and full necropsy was performed at study termination (∼29 months)...
2016: Oncology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"