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https://www.readbyqxmd.com/read/28646880/6-shogaol-a-neuroactive-compound-of-ginger-jahe-gajah-induced-neuritogenic-activity-via-ngf-responsive-pathways-in-pc-12-cells
#1
Syntyche Ling Sing Seow, Sok Lai Hong, Guan Serm Lee, Sri Nurestri Abd Malek, Vikineswary Sabaratnam
BACKGROUND: Ginger is a popular spice and food preservative. The rhizomes of the common ginger have been used as traditional medicine to treat various ailments. 6-Shogaol, a pungent compound isolated from the rhizomes of jahe gajah (Zingiber officinale var officinale) has shown numerous pharmacological activities, including neuroprotective and anti-neuroinflammatory activities. The aim of this study was to investigate the potential of 6-shogaol to mimic the neuritogenic activity of nerve growth factor (NGF) in rat pheochromocytoma (PC-12) cells...
June 24, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28642614/ultrasound-mediated-piezoelectric-differentiation-of-neuron-like-pc12-cells-on-pvdf-membranes
#2
Marcus Hoop, Xiang-Zhong Chen, Aldo Ferrari, Fajer Mushtaq, Gagik Ghazaryan, Theo Tervoort, Dimos Poulikakos, Bradley Nelson, Salvador Pané
Electrical and/or electromechanical stimulation has been shown to play a significant role in regenerating various functionalities in soft tissues, such as tendons, muscles, and nerves. In this work, we investigate the piezoelectric polymer polyvinylidene fluoride (PVDF) as a potential substrate for wireless neuronal differentiation. Piezoelectric PVDF enables generation of electrical charges on its surface upon acoustic stimulation, inducing neuritogenesis of PC12 cells. We demonstrate that the effect of pure piezoelectric stimulation on neurite generation in PC12 cells is comparable to the ones induced by neuronal growth factor (NGF)...
June 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28637693/neuroblast-differentiation-during-development-and-in-neuroblastoma-requires-kif1b%C3%AE-mediated-transport-of-trka
#3
Stuart M Fell, Shuijie Li, Karin Wallis, Anna Kock, Olga Surova, Vilma Rraklli, Carolin S Höfig, Wenyu Li, Jens Mittag, Marie Arsenian Henriksson, Rajappa S Kenchappa, Johan Holmberg, Per Kogner, Susanne Schlisio
We recently identified pathogenic KIF1Bβ mutations in sympathetic nervous system malignancies that are defective in developmental apoptosis. Here we deleted KIF1Bβ in the mouse sympathetic nervous system and observed impaired sympathetic nervous function and misexpression of genes required for sympathoadrenal lineage differentiation. We discovered that KIF1Bβ is required for nerve growth factor (NGF)-dependent neuronal differentiation through anterograde transport of the NGF receptor TRKA. Moreover, pathogenic KIF1Bβ mutations identified in neuroblastoma impair TRKA transport...
May 15, 2017: Genes & Development
https://www.readbyqxmd.com/read/28637031/association-between-metabolic-syndrome-and-serum-nerve-growth-factor-levels-in-women-with-overactive-bladder
#4
Hediye Dagdeviren, Huseyin Cengiz
OBJECTIVE: This study aimed to determine the association between overactive bladder (OAB), metabolic syndrome (MetS) and serum nerve growth factors (NGF). STUDY DESIGN: Serum samples from a group of 90 women that included patients with OAB (group 1), patients with both OAB and MetS (group 2) and healthy women without OAB and MetS (group 3). Each group included 30 patients. Serum levels of NGF were compared among the groups. RESULTS: When the groups were compared with respect to NGF levels, group 2 was found to have significantly higher NGF levels (p = 0...
June 22, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/28633971/manganese-enhanced-magnetic-resonance-imaging-depicts-brain-activity-in-models-of-acute-and-chronic-pain-a-new-window-to-study-experimental-spontaneous-pain
#5
I M Devonshire, J J Burston, L Xu, A Lillywhite, M J Prior, D J G Watson, C M Greenspon, S J Iwabuchi, D P Auer, V Chapman
Application of functional imaging techniques to animal models is vital to understand pain mechanisms, but is often confounded by the need to limit movement artefacts with anaesthesia, and a focus on evoked responses rather than clinically relevant spontaneous pain and related hyperalgesia. The aim of the present study was to investigate the potential of manganese-enhanced magnetic resonance imaging (MEMRI) to measure neural responses during on-going pain that underpins hyperalgesia in pre-clinical models of nociception...
June 17, 2017: NeuroImage
https://www.readbyqxmd.com/read/28632904/ngf-and-fgf-2-promote-reinnervation-by-nerve-muscle-endplate-grafting
#6
Liancai Mu, Stanislaw Sobotka, Jingming Chen, Themba Nyirenda
INTRODUCTION: This study was designed to test whether exogenous application of nerve growth factor (NGF) and basic fibroblast growth factor (FGF-2) to muscles reinnervated with nerve-muscle-endplate band grafting (NMEG) could promote specific outcomes. METHODS: The right sternomastoid muscle in adult rats was experimentally denervated and immediately reinnervated by implanting a NMEG pedicle from the ipsilateral sternohyoid muscle. A fibrin sealant containing NGF and FGF-2 was focally applied to the implantation site...
June 20, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28632177/the-intersection-of-ngf-trka-signaling-and-amyloid-precursor-protein-processing-in-alzheimer-s-disease-neuropathology
#7
REVIEW
Nadia Canu, Giuseppina Amadoro, Viviana Triaca, Valentina Latina, Valentina Sposato, Veronica Corsetti, Cinzia Severini, Maria Teresa Ciotti, Pietro Calissano
Dysfunction of nerve growth factor (NGF) and its high-affinity Tropomyosin receptor kinase A (TrkA) receptor has been suggested to contribute to the selective degeneration of basal forebrain cholinergic neurons (BFCN) associated with the progressive cognitive decline in Alzheimer's disease (AD). The aim of this review is to describe our progress in elucidating the molecular mechanisms underlying the dynamic interplay between NGF/TrkA signaling and amyloid precursor protein (APP) metabolism within the context of AD neuropathology...
June 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28632034/recombinant-human-nerve-growth-factor-treatment-promotes-photoreceptor-survival-in-the-retinas-of-rats-with-retinitis-pigmentosa
#8
Marta Sacchetti, Flavio Mantelli, Maria Luisa Rocco, Alessandra Micera, Laura Brandolini, Laura Focareta, Claudio Pisano, Luigi Aloe, Alessandro Lambiase
PURPOSE: Increasing evidence suggests that nerve growth factor (NGF) exerts protective effects against retinal degeneration in animal models of retinitis pigmentosa (RP). This study aims at investigating the effects of intravitreal injection of recombinant human NGF (rhNGF) on retinal photoreceptors apoptosis in an animal model of RP, the Royal College of Surgeons (RCS) rats. METHODS: Thirty-six RCS rats were treated with intravitreal injection of rhNGF or murine NGF (mNGF) or vehicle at 20 postnatal days (pd) and sacrificed at 40 pd...
March 1, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28629826/silencing-of-fkbp51-alleviates-the-mechanical-pain-threshold-inhibits-drg-inflammatory-factors-and-pain-mediators-through-the-nf-kappab-signaling-pathway
#9
Hong-Mei Yu, Qi Wang, Wen-Bo Sun
Neuropathic pain is chronic pain caused by lesions or diseases of the somatosensory system, currently available analgesics provide only temporal relief. The precise role of FK506 binding protein 51 (FKBP51) in neuropathic pain induced by chronic constriction injury (CCI) is not clear. The purpose of the present study was to investigate the effects and possible mechanisms of FKBP51 in neuropathic pain in the rat model of CCI. Our results showed that FKBP51 was obviously upregulated in a time-dependent manner in the dorsal root ganglion (DRG) in CCI rats...
June 16, 2017: Gene
https://www.readbyqxmd.com/read/28629798/proteomic-analysis-of-mesenchymal-to-schwann-cell-transdifferentiation
#10
Anup D Sharma, Jayme Wiederin, Metin Uz, Pawel Ciborowski, Surya K Mallapragada, Howard E Gendelman, Donald S Sakaguchi
While transplantation of Schwann cells facilitates axon regeneration, remyelination and repair after peripheral nerve injury clinical use is limited by cell bioavailability. We posit that such limitation in cell access can be overcome by the use of autologous bone-marrow derived mesenchymal stem cells (MSCs). As MSCs can transdifferentiate to Schwann cell-phenotypes and accelerate nerve regeneration we undertook proteomic evaluation of the cells to uncover the protein contents that affects Schwann cell formulation...
June 16, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28629024/electrospun-silk-fibroin-scaffolds-coated-with-reduced-graphene-promote-neurite-outgrowth-of-pc-12-cells-under-electrical-stimulation
#11
Salvador Aznar-Cervantes, Ana Pagán, Jose G Martínez, Antonia Bernabeu-Esclapez, Toribio F Otero, Luis Meseguer-Olmo, Juan I Paredes, Jose L Cenis
Novel approaches to neural research require biocompatible materials capable to act as electrode structures or scaffolds for tissue engineering in order to stimulate or restore the functionality of damaged tissues. This work offers promising results that indicate the potential use of electrospun silk fibroin (SF) scaffolds coated with reduced graphene oxide (rGO) in this sense. The coated material becomes conductor and electroactive. A complete characterisation of SF/rGO scaffolds is provided in terms of electrochemistry, mechanical behaviour and chemical conformation of fibroin...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28627670/intermedin-improves-cardiac-function-and-sympathetic-neural-remodeling-in-a-rat-model-of-post-myocardial-infarction-heart-failure
#12
Bin Xu, Hao Xu, Heng Cao, Xiaoxiao Liu, Chunhuan Qin, Yanzhou Zhao, Xiaolin Han, Hongli Li
Emerging evidence has suggested that intermedin (IMD), a novel member of the calcitonin gene‑related peptide (CGRP) family, has a wide range of cardioprotective effects. The present study investigated the effects of long‑term administration of IMD on cardiac function and sympathetic neural remodeling in heart failure (HF) rats, and studied potential underlying mechanism. HF was induced in rats by myocardial infarction (MI). Male Sprague Dawley rats were randomly assigned to either saline or IMD (0.6 µg/kg/h) treatment groups for 4 weeks post‑MI...
June 14, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28626808/attenuation-of-opioid-tolerance-by-etb-receptor-agonist-irl-1620-is-independent-of-an-accompanied-decrease-in-nerve-growth-factor-in-mice
#13
Shruti Gulati, Seema Briyal, Shantel Jones, Shaifali Bhalla, Anil Gulati
AIM: ETA receptor antagonists reverse opioid tolerance but the involvement of ETB receptors is unknown. In morphine or oxycodone tolerant mice we investigated (1) the effect of ETB receptor agonist, IRL-1620, on analgesic tolerance; (2) changes in expression of the brain ETA and ETB receptors; and (3) alterations in the brain VEGF, NGF, PI3K and notch-1 expression. MAIN METHODS: Body weight, body temperature, and tail-flick latency were assessed before and after a challenge dose of morphine or oxycodone in vehicle or IRL-1620 treated mice...
June 2017: Heliyon
https://www.readbyqxmd.com/read/28624392/role-of-fractalkine-cx3cr1-signaling-pathway-in-the-recovery-of-neurological-function-after-early-ischemic-stroke-in-a-rat-model
#14
Yan-Zhi Liu, Chun Wang, Qian Wang, Yong-Zhong Lin, Yu-Song Ge, Dong-Mei Li, Geng-Sheng Mao
This study aims to explore the role of fractalkine/CX3C chemokine receptor 1 (CX3CR1) signaling pathway in the recovery of neurological functioning after an early ischemic stroke in rats. After establishment of permanent middle cerebral artery occlusion (pMCAO) models, 50 rats were divided into blank, sham, model, positive control and CX3CR1 inhibitor groups. Neurological impairment, walking and grip abilities, and cortical and hippocampal infarctions were evaluated by Zea Longa scoring criterion, beam-walking assay and grip strength test, and diffusion-weighted magnetic resonance imaging...
June 14, 2017: Life Sciences
https://www.readbyqxmd.com/read/28624172/development-of-an-imaging-mitigation-strategy-for-patient-enrolment-in-the-tanezumab-nerve-growth-factor-inhibitor-ngf-ab-program-with-a-focus-on-eligibility-assessment
#15
Frank W Roemer, Colin G Miller, Christine R West, Mark T Brown, Sarah P Sherlock, Andrew J Kompel, Luis Diaz, Nicholas Galante, Michel D Crema, Ali Guermazi
OBJECTIVE: Nerve growth factor antibodies (NGF-ab) have shown promising analgesic efficacy. Aim was to describe reader training efforts and present reliability data focusing on radiographic eligibility in the tanezumab program. METHODS: A multi-step process was used for reader calibration and reliability testing. First, a reference standard set of cases was created and diagnostic performance was evaluated. A second exercise focused on agreement of ordinal assessment (Kellgren-Lawrence grading) of radiographic osteoarthritis...
May 20, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28616913/-the-effect-of-exogenous-recombinant-hmgb1-on-neural-stem-cells-and-related-mechanism
#16
Hui-Min Zhang, Bo Wu, Tian Cao, Yu-Ying Yan, Ming Liu
OBJECTIVES: To explore the effect of exogenous recombinant high mobility group protein box1 (rHMGB1) on proliferation and differentiation of neural stem cells (NSCs) and the related mechanism. METHODS: SD rat cerebral cortex cells were cultured in serum-free medium, extending the culture and purification of neural stem cells. NSCs were identified by detecting nestin-label with immunofluorescence method.The NSCs proliferation activity after adding different concentrations of rHMGB1 was determined by CCK-8 assay and the optimal concentration of rHMGB1 for the follow-up experiments was selected...
May 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28615336/prevention-and-reversal-of-latent-sensitization-of-dorsal-horn-neurons-by-glial-blockers-in-a-model-of-low-back-pain-in-male-rats
#17
Juanjuan Zhang, Siegfried Mense, Rolf-Detlef Treede, Ulrich Hoheisel
In an animal model of non-specific low back pain, recordings from dorsal horn neurons were made to investigate the influence of glial cells in the central sensitization process. To induce a latent sensitization of the neurons, nerve growth factor (NGF) was injected into the multifidus muscle; the manifest sensitization to a second NGF injection 5 days later was used as a read-out. The sensitization manifested in increased resting activity and in an increased proportion of neurons responding to stimulation of deep somatic tissues...
June 14, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28615040/immunohistochemical-and-immunocytochemical-study-of-mechanoreceptors-in-anterior-cruciate-ligament-reconstruction-with-the-remnant-preserving-technique-using-achilles-tendon-allografts
#18
Keun Churl Chun, Sung Hyun Lee, Jeong Woo Kim, Eun Jung Jin, Kwang Mee Kim, Churl Hong Chun
BACKGROUND: Attempts have been made to validate the significance of remnant preservation with anterior cruciate ligament (ACL) reconstruction using immunohistochemical and immunocytochemical techniques. The purpose of this study was to examine the expression of mechanoreceptors in the remnant tissue of ACL reconstruction performed with the remnant-preserving technique. METHODS: Tissue samples were obtained from 10 patients who underwent ACL reconstruction with the remnant-preserving technique...
June 14, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28610652/novel-insights-into-the-role-of-cell-free-seminal-mrnas-on-semen-quality-and-cryotolerance-of-spermatozoa-in-bulls-bos-taurus
#19
Munivenkatappa Shilpa, Sellappan Selvaraju, Venkataswamy GirishKumar, Sivashanmugam Parthipan, Krishnan B Binsila, Arunachalam Arangasamy, Janivara Parameshwaraiah Ravindra
The aim of the present study was to ascertain the effectiveness of seminal plasma mRNAs as markers to assess the reproductive performance of bulls. Semen samples (33 ejaculates) from 11 bulls were evaluated for sperm kinematic and functional parameters. Total RNA was isolated from cell-free seminal (cfs) using TRIzol LS reagent and the concentration of cfs-RNA was 24.4±2.3µgmL-1 seminal plasma. The cfs-RNA was fragmented to a size of 25-500bp. Of the cfs-mRNAs screened using real time PCR, expression of protamine 1 (PRM1) was positively (P<0...
June 14, 2017: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/28606823/alpha-lipoic-acid-attenuates-acute-neuroinflammation-and-long-term-cognitive-impairment-after-polymicrobial-sepsis
#20
Amanda Della Giustina, Mariana Pereira Goldim, Lucinéia Gainski Danielski, Drielly Florentino, Khiany Mathias, Leandro Garbossa, Aloir Neri Oliveira Junior, Maria Eduarda Fileti, Graciela Freitas Zarbato, Naiana da Rosa, Ana Olívia Martins Laurentino, Jucélia Jeremias Fortunato, Francielle Mina, Tatiani Bellettini-Santos, Josiane Budni, Tatiana Barichello, Felipe Dal-Pizzol, Fabricia Petronilho
Sepsis is a complication of an infection which imbalance the normal regulation of several organ systems, including the central nervous system (CNS). Evidence points towards inflammation and oxidative stress as major steps associated with brain dysfunction in sepsis. Thus, we investigated the α-lipoic acid (ALA) effect as an important antioxidant compound on brain dysfunction in rats. Wistar rats were subjected to sepsis by cecal ligation and perforation (CLP) or sham (control) and treated orally with ALA (200 mg/kg after CLP) or vehicle...
June 10, 2017: Neurochemistry International
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