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https://www.readbyqxmd.com/read/29328070/nerve-growth-factor-upregulates-sirtuin-1-expression-in-cholestasis-a-potential-therapeutic-target
#1
Ming-Shian Tsai, Po-Huang Lee, Cheuk-Kwan Sun, Ting-Chia Chiu, Yu-Chun Lin, I-Wei Chang, Po-Han Chen, Ying-Hsien Kao
This study investigated the regulatory role of nerve growth factor (NGF) in sirtuin 1 (SIRT1) expression in cholestatic livers. We evaluated the expression of NGF and its cognate receptors in human livers with hepatolithiasis and the effects of NGF therapy on liver injury and hepatic SIRT1 expression in a bile duct ligation (BDL) mouse model. Histopathological and molecular analyses showed that the hepatocytes of human diseased livers expressed NGF, proNGF (a precursor of NGF), TrkA and p75NTR, whereas only p75NTR was upregulated in hepatolithiasis, compared with non-hepatolithiasis livers...
January 12, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29325876/nogo-a-interacts-with-trka-to-alter-nerve-growth-factor-signaling-in-nogo-a-overexpressing-pc12-cells
#2
Robert G Farrer, Gwendolyn L Kartje
The Nogo-A protein, originally discovered as a potent myelin-associated inhibitor of neurite outgrowth, is also expressed by certain neurons, especially during development and after injury, but its role in neuronal function is not completely known. In this report, we overexpressed Nogo-A in PC12 cells to use as a model to identify potential neuronal signaling pathways affected by endogenously expressed Nogo-A. Unexpectedly, our results show that viability of Nogo-A-overexpressing cells was reduced progressively due to apoptotic cell death following NGF treatment, but only after 24 h...
January 8, 2018: Cellular Signalling
https://www.readbyqxmd.com/read/29325386/-the-protective-effect-of-the-activation-of-nmdar1-erk1-2-signal-pathway-induced-by-levodopa-on-visual-cortical-neurons-in-monocular-deprivation-rats
#3
X N Sun, H L Wang, G Qiao, J Tao, C Liu, X H Hao
Objective: To investigate the protection effects of the activation of NMDAR1(NMDA receptor 1)/ERK1/2 signal pathway on visual cortex nerve cells induced by levodopa in amblyopia rats. Methods: SD rats of SPF grade, were randomly divided into for groups of 9, group A. Control, B. MD group, C. L-levodopa(20 mg·kg(-1))+MD group, D. H-levodopa (80 mg·kg(-1))+MD group, E. H-levodopa+MD+MK801 group, F. H-levodopa+MD+PD98059 group, G. MD+MK801 group, H. MD+PD98059 group, I. MD+DMSO group. Amblyopia rats were made by suture of the right eye...
December 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29320631/thermoresponsive-co-biodegradable-linear-dendritic-nanoparticles-for-sustained-release-of-nerve-growth-factor-to-promote-neurite-outgrowth
#4
Young Shin Kim, Muhammad Gulfam, Tao L Lowe
Thermo-responsive and biodegradable linear-dendritic nanoparticles containing poly(N-isopropylacrylamide), poly(L-lactic acid) and poly(L-lysine) dendron were investigated for sustained release of nerve growth factor (NGF) in response to temperature change. The nanoparticles and their degradants were not cytotoxic to neuron-like PC12 cells for at least one month. The nanoparticles were preferentially taken up by PC12 cells 6 to 13 times more at temperature above (37 °C) than below (25 °C) the lower critical solution temperature of the nanoparticles...
January 10, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29311515/secoiridoid-glycosides-from-the-twigs-of-ligustrum-obtusifolium-possess-anti-inflammatory-and-neuroprotective-effects
#5
Won Se Suh, Oh Kil Kwon, Tae Hyun Lee, Lalita Subedi, Sun Yeou Kim, Kang Ro Lee
Two new secoiridoid glycosides, obtusifolisides A and B (1, 2), together with 7 known secoiridoid glycosides (3-9) were isolated from the twigs of Ligustrum obtusifolium. The chemical structures of new compounds were determined by a spectroscopic data analysis, including one and two dimensional (1D-, 2D)-NMR, High resolution-MS, and experiments involving chemical reactions. The isolated secoiridoid glycosides were evaluated for their anti-inflammatory effects in lipopolysaccharide (LPS)-stimulated BV-2 murine microglia cells...
2018: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29301234/the-effect-of-coatings-and-nerve-growth-factor-on-attachment-and-differentiation-of-pheochromocytoma-cells
#6
Anna Orlowska, Pallale Tharushi Perera, Mohammad Al Kobaisi, Andre Dias, Huu Khuong Duy Nguyen, Shahram Ghanaati, Vladimir Baulin, Russell J Crawford, Elena P Ivanova
Cellular attachment plays a vital role in the differentiation of pheochromocytoma (PC12) cells. PC12 cells are noradrenergic clonal cells isolated from the adrenal medulla of Rattus norvegicus and studied extensively as they have the ability to differentiate into sympathetic neuron-like cells. The effect of several experimental parameters including (i) the concentration of nerve growth factor (NGF); (ii) substratum coatings, such as poly-L-lysine (PLL), fibronectin (Fn), and laminin (Lam); and (iii) double coatings composed of PLL/Lam and PLL/Fn on the differentiation process of PC12 cells were studied...
December 31, 2017: Materials
https://www.readbyqxmd.com/read/29298514/increased-calcitonin-gene-related-peptide-and-macrophages-are-involved-in-astragalus-membranaceus-mediated-peripheral-nerve-regeneration-in-rats
#7
Chung-Chia Chen, Ling-Chuan Chang, Chun-Hsu Yao, Yuan-Man Hsu, Jia-Horng Lin, Tse-Yen Yang, Yung-Hsiang Chen, Yueh-Sheng Chen
Astragalus membranaceus (AM) is one of 50 fundamental herbs in traditional Chinese medicine. Previous studies have shown that AM extract can be a potential nerve growth-promoting factor, being beneficial for the growth of peripheral nerve axons. We further investigated the effects of AM extract on regeneration in a rat sciatic nerve transection model. Rats were divided into three groups ([Formula: see text]): normal saline (intraperitoneal) as the control, and 1.5[Formula: see text]g/kg or 3.0[Formula: see text]g/kg of AM extract (every other day for four weeks), respectively...
January 3, 2018: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29298466/urinary-nerve-growth-factor-as-a-potential-biomarker-of-treatment-outcomes-in-overactive-bladder-patients
#8
Yoon Seok Suh, Kwang Jin Ko, Tae Heon Kim, Hyo Serk Lee, Hyun Hwan Sung, Won Jin Cho, Kyu-Sung Lee
PURPOSE: The aim of this study was to investigate urinary nerve growth factor (NGF) as a biomarker of treatment efficacy and recurrence in overactive bladder (OAB) patients. METHODS: We enrolled 189 OAB subjects who visited our outpatient clinic from February 2010 to February 2015. All subjects with OAB received antimuscarinic treatment. A 3-day voiding diary and questionnaire were collected from each patient. Urinary levels of NGF were evaluated at baseline, the beginning of antimuscarinic treatment, and the end of antimuscarinic treatment...
December 2017: International Neurourology Journal
https://www.readbyqxmd.com/read/29288797/peripheral-synthesis-of-an-atypical-protein-kinase-c-mediates-the-enhancement-of-excitability-and-the-development-of-mechanical-hyperalgesia-produced-by-nerve-growth-factor
#9
Joanne Kays, Yi Hong Zhang, Alla Khorodova, Gary Strichartz, Grant D Nicol
Nerve growth factor plays a key role in the initiation as well as the prolonged heightened pain sensitivity of the inflammatory response. Previously, we showed that NGF rapidly augmented both the excitability of isolated rat sensory neurons and the mechanical sensitivity of the rat's hind paw. The increase in excitability and sensitivity were blocked by the myristolated pseudosubstrate inhibitor of atypical PKCs (mPSI), suggesting that an atypical PKC may play a key regulatory role in generating this heightened sensitivity...
December 27, 2017: Neuroscience
https://www.readbyqxmd.com/read/29287688/anti-inflammatory-effect-of-atb-352-a-h2s-releasing-ketoprofen-derivative-on-lipopolysaccharide-induced-periodontitis-in-rats
#10
Enrico Gugliandolo, Roberta Fusco, Ramona D'Amico, Angela Militi, Giacomo Oteri, John L Wallace, Rosanna Di Paola, Salvatore Cuzzocrea
Periodontal disease is the most common cause of tooth loss in humans, is an inflammatory disease initiated by oral microbial biofilm. Given the involvement of the inflammatory pathway in this type of pathology, the main pharmacological strategy for the treatment of periodontitis, is the inhibition of the inflammatory process in order to prevent tissue destruction and bone resorption, a condition associated with a painful state. To do this, the best class of drugs are Non-steroidal anti-inflammatory drugs (NSAIDs), however, the presence of side effects, especially at the gastrointestinal tract, limits their use for long-term therapy...
December 26, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29285284/activation-of-the-ngf-trka-signaling-pathway-attenuates-diabetic-erectile-dysfunction
#11
Yi Hou, Linpei Jia, Ying Zhang, Wei Ji, Hai Li
Erectile dysfunction (ED) is a common complication of diabetes mellitus (DM). The exact role of the NGF/TrkA signaling pathway in the pathogenesis of diabetic ED is largely unknown. In the present study, we investigated the role of the NGF/TrkA signaling pathway in Sprague-Dawley rats with diabetic ED. Animals were divided into 2 groups: the normal group and the DM ED model group. The model group included the blank subgroup, the negative control (NC) subgroup, the TrkA subgroup and the TrkA + NGF subgroup. Erectile function, intracavernous pressure (ICP) and mean arterial pressure were measured respectively...
December 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/29281262/binding-of-zn-ii-to-tropomyosin-receptor-kinase-a-in-complex-with-its-cognate-nerve-growth-factor-insights-from-molecular-simulation-and-in-vitro-essays
#12
Adriana Pietropaolo, Antonio Magrì, Valentina Greco, Valeria Losasso, Diego La Mendola, Sebastiano Sciuto, Paolo Carloni, Enrico Rizzarelli
The binding of the human nerve growth factor (NGF) protein to the tropomyosin-receptor-kinase A (TrkA) is associated with Alzhemeir's development. Owing to the large presence of zinc(II) ions in the synaptic compartments, the zinc ions might be bound to the complex in vivo. Here, we have identified a putative zinc binding site using a combination of computations and experiments. First, we have predicted structural features of the NGF/TrkA complex in aqueous solution by molecular simulation. Metadynamics free energy calculations suggest that these are very similar to those in the X-ray structure...
December 27, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29280518/a-new-tool-to-test-active-ingredient-using-acid-lactic-in-vitro-a-help-to-understand-cellular-mechanism-involved-in-stinging-test-an-example-using-a-bacterial-polysaccharide-fucogel%C3%A2
#13
Mehdi Sakka, Raphael Leschiera, Christelle Le Gall, Olivier Gouin, Killian L'herondelle, Paul Buscaglia, Olivier Mignen, Jean-Luc Philbé, Thibaut Saguet, Jean-Luc Carré, Laurent Misery, Nicolas Lebonvallet
The stinging test is an in vivo protocol that evaluates sensitive skin using lactic acid (LA). A soothing sensation of cosmetics or ingredients can be also appreciated through a decrease of stinging score. To predict the soothing sensation of a product before in vivo testing, we developed a model based on an LA test and substance P (SP) release using a co-culture of human keratinocytes and NGF-differentiated PC12 cells. A bacterial fucose-rich polysaccharide present in Fucogel® was evaluated as the soothing molecule in the in vivo stinging test and our in vitro model...
December 27, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/29277983/thymoquinone-can-improve-neuronal-survival-and-promote-neurogenesis-in-rat-hippocampal-neurons
#14
Merve Beker, Tuğçe Dallı, Birsen Elibol
SCOPE: Thymoquinone (TQ) has been used as a potential therapeutic for diseases such as cancer, and diabetes. Herein, we aimed to investigate the effect of TQ on behavioral and molecular parameters in healthy rat hippocampus. METHODS: TQ (20 mg/kg/day) was administered intragastrically for 15 days to adult rats. After the behavioral tests, the hippocampal tissues were investigated in histological and molecular level. RESULTS: In both DG and CA1, TQ significantly increased the number of hippocampal neurons...
December 26, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29276736/maternal-separation-stress-leads-to-resilience-against-neuropathic-pain-in-adulthood
#15
Julien Genty, Milène Tetsi Nomigni, Fernand Anton, Ulrike Hanesch
Early life stress (ELS) leads to a permanent reprogramming of biochemical stress response cascades that may also be relevant for the processing of chronic pain states such as neuropathy. Despite clinical evidence, little is known about ELS-related vulnerability for neuropathic pain and the possibly underlying etiology. In the framework of experimental studies aimed at investigating the respective relationships we used the established ELS model of maternal separation (MS). Rat dams and neonates were separated for 3 h/day from post-natal day 2-12...
February 2018: Neurobiology of Stress
https://www.readbyqxmd.com/read/29274773/nerve-growth-factor-plays-a-role-in-the-neurotherapeutic-effect-of-a-cd45-pan-hematopoietic-subpopulation-derived-from-human-umbilical-cord-blood-in-a-traumatic-brain-injury-model
#16
Galit Gincberg, Esther Shohami, Victoria Trembovler, Alexander G Alexandrovich, Philip Lazarovici, Uriel Elchalal
BACKGROUND AIMS: Human umbilical cord blood (HUCB) is an important source of stem cells for therapy of hematopoietic disorders and is a potential therapy for various neurological disorders, including traumatic brain injury (TBI). The expression of nerve growth factor (NGF) and its receptors TrkA, p75NTR and α9β1 integrin on an HUCB CD45+ pan-hematopoietic subpopulation was investigated in the context of its neurotherapeutic potential after TBI. METHODS: NGF and its receptors were detected on CD45+ cells by reverse transcriptase polymerase chain reaction, flow cytometry analysis and confocal microscopy...
February 2018: Cytotherapy
https://www.readbyqxmd.com/read/29274750/rabbit-seminal-plasma-proteome-the-importance-of-the-genetic-origin
#17
Lucía Casares-Crespo, Paula Fernández-Serrano, José S Vicente, Francisco Marco-Jiménez, María Pilar Viudes-de-Castro
The present study was conducted to characterise rabbit seminal plasma proteins (SP proteins) focusing on the influence of the genetic origin and seasonality. In addition, β-NGF protein quantity in SP was determined. Semen samples were recovered from January to December 2014 using 6 males belonging to genotype A and six from genotype R. For each genotype, one pooled sample at the beginning, middle and end of each season was selected to develop the experiment. A total of 24 pools (3 for each season and genetic line) were analysed...
December 16, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/29274438/the-treatment-of-spinal-cord-injury-in-rats-using-bone-marrow-derived-neural-like-cells-induced-by-cerebrospinal-fluid
#18
Ying Ye, Ting-Ting Feng, Yi-Ran Peng, Shu-Qun Hu, Tie Xu
This study aimed to evaluate the effect of bone mesenchymal stem cells (BMSCs) and BMSC neural-like cells (BMSC-Ns) on the spinal cord injury (SCI) in the rat model of SCI. BMSC-Ns were prepared from the third passage of BMSCs by induction of healthy cerebrospinal fluid (CSF) of an adult human. The SCI rat model was established through a surgical procedure, and after 7 days the rats were randomly divided into 3 (A, B and C) groups. Groups A (BMSC-Ns) and B (BMSCs) were treated with 1 × 106/20 μl cells, while group C (saline) was treated with saline, all via intracerebroventricular injection...
December 20, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29273038/anti-stress-and-neuronal-cell-differentiation-induction-effects-of-rosmarinus-officinalis-l-essential-oil
#19
Myra O Villareal, Ayumi Ikeya, Kazunori Sasaki, Abdelkarim Ben Arfa, Mohamed Neffati, Hiroko Isoda
BACKGROUND: Mood disorder accounts for 13 % of global disease burden. And while therapeutic agents are available, usually orally administered, most have unwanted side effects, and thus making the inhalation of essential oils (EOs) an attractive alternative therapy. Rosmarinus officinalis EO (ROEO), Mediterranean ROEO reported to improve cognition, mood, and memory, the effect on stress of which has not yet been determined. Here, the anti-stress effect of ROEO on stress was evaluated in vivo and in vitro...
December 22, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29260495/caffeic-acid-phenethyl-ester-cape-protects-pc12-cells-from-cisplatin-induced-neurotoxicity-by-activating-the-ngf-signaling-pathway
#20
Rafaela Scalco Ferreira, Neife Aparecida Guinaim Dos Santos, Nádia Maria Martins, Laís Silva Fernandes, Antonio Cardozo Dos Santos
Cisplatin is a highly effective chemotherapeutic drug that is toxic to the peripheral nervous system. Findings suggest that axons are early targets of the neurotoxicity of cisplatin. Although many compounds have been reported as neuroprotective, there is no effective treatment against the neurotoxicity of cisplatin. Caffeic acid phenethyl ester (CAPE) is a propolis component with neuroprotective potential mainly attributed to antioxidant and anti-inflammatory mechanisms. We have recently demonstrated the neurotrophic potential of CAPE in a cellular model of neurotoxicity related to Parkinson's disease...
December 19, 2017: Neurotoxicity Research
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