keyword
MENU ▼
Read by QxMD icon Read
search

Tuberculosis and Vitamin D supplementation

keyword
https://www.readbyqxmd.com/read/27826955/vitamin-d-supplementation-for-preventing-infections-in-children-under-five-years-of-age
#1
REVIEW
Mohammad Y Yakoob, Rehana A Salam, Farhan R Khan, Zulfiqar A Bhutta
BACKGROUND: Vitamin D is a micronutrient important for bone growth and immune function. Deficiency can lead to rickets and has been linked to various infections, including respiratory infections. The evidence on the effects of supplementation on infections in children has not been assessed systematically. OBJECTIVES: To evaluate the role of vitamin D supplementation in preventing pneumonia, tuberculosis (TB), diarrhoea, and malaria in children under five years of age...
November 9, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27763570/vitamin-d-status-and-its-consequences-for-health-in-south-africa
#2
Mary Norval, Anna K Coussens, Robert J Wilkinson, Liza Bornman, Robyn M Lucas, Caradee Y Wright
In this review, reports were retrieved in which vitamin D status, as assessed by serum 25-hydroxyvitamin D [25(OH)D] levels, was measured in South African population groups with varied skin colours and ethnicities. Healthy children and adults were generally vitamin D-sufficient [25(OH)D level >50 nmol/L] but the majority of those aged above 65 years were deficient. A major role for exposure to solar ultraviolet radiation (UVR) in determining 25(OH)D levels was apparent, with the dietary contribution being minor...
October 18, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27663379/association-between-vitamin-d-supplementation-and-severity-of-tuberculosis-in-wild-boar-and-red-deer
#3
D Risco, F J Salguero, R Cerrato, J Gutierrez-Merino, S Lanham-New, O Barquero-Pérez, J Hermoso de Mendoza, P Fernández-Llario
Tuberculosis (TB) is a chronic disease affecting humans and other mammal species. Severity of TB caused by Mycobacterium tuberculosis in humans seems to be influenced by nutritional factors like vitamin D3 intake. However, this relationship has been scarcely studied in cattle and other mammals infected with Mycobacterium bovis. The aim of this work was to assess if wildlife reservoirs of M. bovis show different levels of TB severity depending on the level of vitamin D found in serum after supplementation with vitamin D3...
October 2016: Research in Veterinary Science
https://www.readbyqxmd.com/read/27449998/effect-of-1-25-dihydroxyvitamin-d3-on-the-expression-of-mannose-receptor-dc-sign-and-autophagy-genes-in-pulmonary-tuberculosis
#4
K Afsal, P Selvaraj
1,25-dihydroxyvitamin D3 [1,25(OH)2D3] is a powerful immuno-modulator, which enhances expression of antimicrobial peptides and induces autophagy in monocytes/macrophages. Since 1,25(OH)2D3 increases the phagocytic potential of monocytes/macrophages, we have explored the effect of 1,25(OH)2D3 on the expression of receptors such as mannose receptor (CD206) and DC-SIGN (CD209) as well as autophagy genes such as ATG5 and Beclin-1 (BECN1) in monocytes/macrophages of healthy controls (HCs) and pulmonary tuberculosis (PTB) patients with and without cavitary disease...
July 2016: Tuberculosis
https://www.readbyqxmd.com/read/27365952/effect-of-vitamin-b12-and-folic-acid-supplementation-on-neuropsychiatric-symptoms-and-immune-response-in-hiv-positive-patients
#5
Prabha M Adhikari, Mukta N Chowta, John T Ramapuram, Satish B Rao, Karthik Udupa, Sahana D Acharya
BACKGROUND: Micronutrients such as B12 and folic acid deficiencies are found in higher number in HIV-infected patients. OBJECTIVE: We conducted a study to examine the effect of Vitamin B12 and folic acid supplementation on neuropsychiatric manifestations, CD4 count, and anthropometric measurements in HIV-positive patients. MATERIALS AND METHODS: Three different groups of HIV patients, namely, HIV patients with tuberculosis, HIV patients with neuropsychiatric manifestations, and asymptomatic HIV patients with 50 patients in each group were included in the study...
July 2016: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/27355911/nutritional-supplements-for-people-being-treated-for-active-tuberculosis
#6
REVIEW
Liesl Grobler, Sukrti Nagpal, Thambu D Sudarsanam, David Sinclair
BACKGROUND: Tuberculosis and malnutrition are linked in a complex relationship. Tuberculosis may cause undernutrition through increased metabolic demands and decreased intake, and nutritional deficiencies may worsen the disease, or delay recovery by depressing important immune functions. At present, there is no evidence-based nutritional guidance for adults and children being treated for tuberculosis. OBJECTIVES: To assess the effects of oral nutritional supplements in people being treated with antituberculous drug therapy for active tuberculosis...
June 29, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27009076/vitamin-d-and-airway-infections-a-european-perspective
#7
REVIEW
Armin Zittermann, Stefan Pilz, Harald Hoffmann, Winfried März
Vitamin D has immuno-modulatory properties, and deficient levels of circulating 25-hydroxyvitamin D (<30 nmol/l) may contribute to increased risk of infectious illnesses. This narrative review summarises data on vitamin D status in Europe and updates results of randomised controlled trials (RCTs) regarding vitamin D and airway infections such as tuberculosis (TB) and acute upper respiratory tract infection. In Europe, the prevalence of vitamin D deficiency is up to 37% in the general population and up to 80% in nursing home residents and non-European immigrants...
March 24, 2016: European Journal of Medical Research
https://www.readbyqxmd.com/read/26985430/a-review-of-vitamin-d-effects-on-common-respiratory-diseases-asthma-chronic-obstructive-pulmonary-disease-and-tuberculosis
#8
REVIEW
Mohammad Esmaeil Hejazi, Faezeh Modarresi-Ghazani, Taher Entezari-Maleki
Despite the classic role of Vitamin D in skeletal health, new aspects of Vitamin D have been discovered in tissues and organs other than bones. Epidemiological and observational studies demonstrate a link between Vitamin D deficiency and risk of developing respiratory diseases including asthma, chronic obstructive pulmonary disease (COPD), and tuberculosis (TB). To review the literature, we searched the terms "Vitamin D" (using the set operator) and "asthma," "COPD" and "TB" in electronic databases, including PubMed/MEDLINE, Scopus, and Google Scholar until July 2015...
January 2016: Journal of Research in Pharmacy Practice
https://www.readbyqxmd.com/read/26872154/low-vitamin-d-levels-combined-with-pkp3-sigirr-tmem16j-host-variants-is-associated-with-tuberculosis-and-death-in-hiv-infected-and-exposed-infants
#9
Amita Gupta, Grace Montepiedra, Akshay Gupte, Bret Zeldow, Jennifer Jubulis, Barbara Detrick, Avy Violari, Shabir Madhi, Raziya Bobat, Mark Cotton, Charles Mitchell, Stephen Spector
BACKGROUND: This study examined the associations of 25-hydroxyvitamin D and specific host genetic variants that affect vitamin D levels or its effects on immune function, with the risk of TB or mortality in children. METHODS: A case-cohort sample of 466 South African infants enrolled in P1041 trial (NCT00080119) underwent 25-hydroxyvitamin D testing by chemiluminescent immunoassay. Single nucleotide polymorphisms (SNPs) that alter the effect of vitamin D [e.g. vitamin D receptor (VDR)], vitamin D levels [e...
2016: PloS One
https://www.readbyqxmd.com/read/26557587/acute-hypercalcaemia-and-hypervitaminosis-d-in-an-infant-with-extra-pulmonary-tuberculosis
#10
Devi Dayal, Siya Ram Didel, Sikha Agarwal, Naresh Sachdeva, Meenu Singh
In patients with tuberculosis, abnormal extrarenal production of 1,25-dihydroxyvitamin D3 by activated macrophages in granulomatous tissues may result in hypercalcaemia. More commonly reported in adults with active pulmonary tuberculosis, this complication may rarely occur in extrapulmonary tuberculosis, and children. The hypercalcaemia may be precipitated by usually recommended vitamin D and calcium supplementation in patients with tuberculosis. We report here an infant with tubercular meningitis who developed hypercalcaemia 12 days after starting routine vitamin D and calcium supplementation...
October 2015: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/26521023/vitamin-d-and-respiratory-tract-infections-in-childhood
#11
REVIEW
Susanna Esposito, Mara Lelii
BACKGROUND: Respiratory tract infections (RTIs) remain among of the most important causes of morbidity and mortality among children. Several studies have associated vitamin D deficiency with an increased risk of RTIs, and vitamin D supplementation has been proposed as a possible preventive measure against RTIs in children. The main aim of this review is to summarize the current evidence from the literature about the link between vitamin D and RTIs in children. DISCUSSION: Several recent studies have shown that vitamin D has different immunomodulatory properties associated with the risk of RTIs in childhood...
2015: BMC Infectious Diseases
https://www.readbyqxmd.com/read/26479950/role-of-vitamin-d-in-cytotoxic-t-lymphocyte-immunity-to-pathogens-and-cancer
#12
REVIEW
Surojit Sarkar, Martin Hewison, George P Studzinski, Yan Chun Li, Vandana Kalia
The discovery of vitamin D receptor (VDR) expression in immune cells has opened up a new area of research into immunoregulation by vitamin D, a niche that is distinct from its classical role in skeletal health. Today, about three decades since this discovery, numerous cellular and molecular targets of vitamin D in the immune system have been delineated. Moreover, strong clinical associations between vitamin D status and the incidence/severity of many immune-regulated disorders (e.g. infectious diseases, cancers and autoimmunity) have prompted the idea of using vitamin D supplementation to manipulate disease outcome...
2016: Critical Reviews in Clinical Laboratory Sciences
https://www.readbyqxmd.com/read/26307505/vitamin-d-status-in-south-africa-and-tuberculosis
#13
REVIEW
Abhimanyu, Vanessa Meyer, Tamsyn Jacki Jeffery, Liza Bornman
According to the World Health Organisation South Africa has the third highest tuberculosis (TB) incidence in the world, with an estimated 60 % incident cases having both TB and HIV. The South African National Tuberculosis Association (SANTA) recognized the importance of nutrition in the prevention and management of TB by including feeding schemes in community outreach programs. Vitamin D enhances innate immunity against mycobacterial infection through the antimicrobial peptide, cathelicidin. We reviewed studies on vitamin D status, its link with TB, and potential use in therapy in multiethnic South Africa with sunlight as primary source of vitamin D...
December 2015: Lung
https://www.readbyqxmd.com/read/26294193/vitamin-d-serum-25-oh-d-ll-37-and-polymorphisms-in-a-canadian-first-nation-population-with-endemic-tuberculosis
#14
COMPARATIVE STUDY
Linda Larcombe, Neeloffer Mookherjee, Joyce Slater, Caroline Slivinski, Joe Dantouze, Matthew Singer, Chris Whaley, Lizette Denechezhe, Sara Matyas, Kate Decter, Emily Turner-Brannen, Clare Ramsey, Peter Nickerson, Pamela Orr
BACKGROUND: Canadian First Nation populations have experienced endemic and epidemic tuberculosis (TB) for decades. Vitamin D-mediated induction of the host defence peptide LL-37 is known to enhance control of pathogens such as Mycobacterium tuberculosis. OBJECTIVE: Evaluate associations between serum levels of 25-hydroxy vitamin D (25(OH)D) and LL-37, in adult Dene First Nation participants (N = 34) and assess correlations with single nucleotide polymorphisms (SNPs) in the vitamin D receptor (VDR) and vitamin D binding protein (VDBP)...
2015: International Journal of Circumpolar Health
https://www.readbyqxmd.com/read/26287796/is-there-a-relationship-between-low-vitamin-d-and-rotaviral-diarrhea
#15
Ibrahim Hakan Bucak, Agah Bahadır Ozturk, Habip Almis, Muhammer Özgür Cevik, Mehmet Tekin, Çapan Konca, Mehmet Turgut, Mehmet Bulbul
BACKGROUND: For children under 5 years of age, 1700 000 000 episodes of diarrhea are seen worldwide, and death occurs in 700 000 of these cases due to diarrhea. Rotavirus is an important cause of diarrhea in this age group, and many studies have shown that vitamin D plays a pivotal role in the immune system, as well as in antimicrobial peptide gene expression. In addition, lower vitamin D has been correlated with higher rates of infectious diseases such as respiratory tract infection, tuberculosis, and viral infection...
April 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/26218841/phenylbutyrate-induces-ll-37-dependent-autophagy-and-intracellular-killing-of-mycobacterium-tuberculosis-in-human-macrophages
#16
Rokeya Sultana Rekha, S S V Jagadeeswara Rao Muvva, Min Wan, Rubhana Raqib, Peter Bergman, Susanna Brighenti, Gudmundur H Gudmundsson, Birgitta Agerberth
LL-37 is a human antimicrobial peptide (AMP) of the cathelicidin family with multiple activities including a mediator of vitamin D-induced autophagy in human macrophages, resulting in intracellular killing of Mycobacterium tuberculosis (Mtb). In a previous trial in healthy volunteers, we have shown that LL-37 expression and subsequent Mtb-killing can be further enhanced by 4-phenylbutyrate (PBA), also an inducer of LL-37 expression. Here, we explore a potential mechanism(s) behind PBA and LL-37-induced autophagy and intracellular killing of Mtb...
2015: Autophagy
https://www.readbyqxmd.com/read/25959993/vitamin-d-supplementation-a-comprehensive-review-on-supplementation-for-tuberculosis-prophylaxis
#17
REVIEW
Eleanor Rachel Turnbull, Francis Drobniewski
Vitamin D plays a large role in the innate immune response against Mycobacterium tuberculosis (MTB) infection, activation and progression. Likewise, vitamin D deficiency is shown by evidence presented here to be a known risk factor for developing both MTB infection and active tuberculosis (TB). This comprehensive review discusses the evidence and remaining questions regarding vitamin D supplementation as a prophylactic measure in those who are at high risk of MTB infection and active TB. Vitamin D supplementation is routinely prescribed for osteoporosis prevention; yet, guidelines are lacking for its prescription for TB prevention, despite the adverse effects being rare...
June 2015: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/25863562/adjunctive-vitamin-d-for-treatment-of-active-tuberculosis-in-india-a-randomised-double-blind-placebo-controlled-trial
#18
RANDOMIZED CONTROLLED TRIAL
Peter Daley, Vijayakumar Jagannathan, K R John, Joy Sarojini, Asha Latha, Reinhold Vieth, Shirly Suzana, Lakshmanan Jeyaseelan, Devasahayam J Christopher, Marek Smieja, Dilip Mathai
BACKGROUND: Vitamin D has immunomodulatory effects that might aid clearance of mycobacterial infection. We aimed to assess whether vitamin D supplementation would reduce time to sputum culture conversion in patients with active tuberculosis. METHODS: We did this randomised, double-blind, placebo-controlled, superiority trial at 13 sites in India. Treatment-naive patients who were sputum-smear positive, HIV negative, and had pulmonary tuberculosis were randomly assigned (1:1), with centrally labelled, serially numbered bottles, to receive standard active tuberculosis treatment with either supplemental high-dose oral vitamin D3 (four doses of 2·5 mg at weeks 0, 2, 4, and 6) or placebo...
May 2015: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/25744368/vitamin-d-immuno-modulation-and-tuberculosis-treatment
#19
REVIEW
Paramasivam Selvaraj, Murugesan Harishankar, Kolloli Afsal
Tuberculosis (TB) is a major global health problem and often coincides with vitamin D deficiency. High doses of vitamin D were widely used to treat TB during the pre-antibiotic era. Vitamin D exerts its action through vitamin D receptor (VDR), and VDR gene polymorphisms are associated with susceptibility or resistance to tuberculosis as well as sputum smear and culture conversion during anti-TB treatment. In-vitro studies have revealed that 1,25-dihydroxyvitamin D3 enhances innate immunity by increased expression of various antimicrobial peptides, including cathelicidin, and induction of autophagy of the infected cells thus restricts the intracellular growth of Mycobacterium tuberculosis in macrophages...
May 2015: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/25663707/immunological-role-of-vitamin-d-at-the-maternal-fetal-interface
#20
REVIEW
J A Tamblyn, M Hewison, C L Wagner, J N Bulmer, M D Kilby
During pregnancy, immune activity is tightly regulated so that antimicrobial protection of the mother and fetus is balanced with the need for immune tolerance to prevent fetal rejection. In this setting, the maternal-fetal interface, in the form of the uterine decidua, provides a heterogeneous immune cell population with the potential to mediate diverse activities throughout pregnancy. Recent studies have suggested that vitamin D may be a key regulator of immune function during pregnancy, with the fetal-maternal interface representing a prominent target...
March 2015: Journal of Endocrinology
keyword
keyword
58502
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"