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https://www.readbyqxmd.com/read/29223808/perfluoroalkyl-acid-levels-in-first-time-mothers-in-relation-to-offspring-weight-gain-and-growth
#1
Irina Gyllenhammar, Barbro Diderholm, Jan Gustafsson, Urs Berger, Peter Ridefelt, Jonathan P Benskin, Sanna Lignell, Erik Lampa, Anders Glynn
We investigated if maternal body burdens of perfluoroalkyl acids (PFAAs) at the time of delivery are associated with birth outcome and if early life exposure (in utero/nursing) is associated with early childhood growth and weight gain. Maternal PFAA body burdens were estimated by analysis of serum samples from mothers living in Uppsala County, Sweden (POPUP), sampled three weeks after delivery between 1996 and 2011. Data on child length and weight were collected from medical records and converted into standard deviation scores (SDS)...
December 7, 2017: Environment International
https://www.readbyqxmd.com/read/29221766/screening-for-fetal-growth-restriction-and-placental-insufficiency
#2
REVIEW
Melanie C Audette, John C Kingdom
Fetal growth restriction (FGR) continues to be a leading cause of preventable stillbirth and poor neurodevelopmental outcomes in offspring, and furthermore is strongly associated with the obstetrical complications of iatrogenic preterm birth and pre-eclampsia. The terms small for gestational age (SGA) and FGR have, for too long, been considered equivalent and therefore used interchangeably. However, the delivery of improved clinical outcomes requires that clinicians effectively distinguish fetuses that are pathologically growth-restricted from those that are constitutively small...
December 5, 2017: Seminars in Fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29217485/developmental-origins-of-adult-health-and-disease-the-metabolic-role-of-bdnf-from-early-life-to-adulthood
#3
REVIEW
Despina D Briana, Ariadne Malamitsi-Puchner
Accumulating evidence suggests that the origins of adult disease may occur during fetal life. Thus, the concept of "developmental programming" has been introduced and supported by epidemiological and experimental data. This concept supports the idea that the nutritional and hormonal status during pregnancy could interfere in metabolism control. The mechanisms responsible for this "developmental programming" remain poorly documented. Current research indicates that neurotrophins and particularly brain-derived neurotrophic factor (BDNF) may play a crucial role in this process...
December 4, 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29216774/chinese-fetal-biometry-reference-equations-and-comparison-with-charts-from-other-populations
#4
Yixiu Zhang, Hua Meng, Yuxin Jiang, Zhonghui Xu, Yunshu Ouyang, Shengli Li, Qian Chen, Qingqing Wu, Rui Li, Tong Ru, Aailu Cai, Xinlin Chen, Taizhu Yang, Ping Chen, Hongning Xie, Hong Lu, Qing Dai, Fen Dong, Meng Yang, Xiao Yang, Jia Lu, Jiawei Tian, Kun Sun, Hui Li
OBJECTIVE: This study aimed to construct new reference charts and equations for fetal biometry from Chinese fetuses at 15-40 weeks and to compare them with previous references. METHOD: This was a prospective, cross-sectional study of singleton pregnancies in patients with a confirmed gestational age who underwent ultrasound examinations between the 15th and 40th weeks of gestation. Each woman was selected only once for this study. Biparietal diameter (BPD), head circumference (HC), abdominal circumference (AC), and femur length (FL) were recorded...
December 7, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29215518/angiogenic-factor-profiles-in-pregnant-women-with-a-history-of-early-onset-severe-preeclampsia-receiving-low-molecular-weight-heparin-prophylaxis
#5
Edouard Lecarpentier, Jean Christophe Gris, Eva Cochery-Nouvellon, Erick Mercier, Cyril Touboul, Ravi Thadhani, S Ananth Karumanchi, Bassam Haddad
OBJECTIVE: To evaluate whether daily low-molecular-weight (LMW) heparin prophylaxis during pregnancy alters profile of circulating angiogenic factors that have been linked with the pathogenesis of preeclampsia and fetal growth restriction. METHODS: This is a planned ancillary study of the Heparin-Preeclampsia trial, a randomized trial in pregnant women with a history of severe early-onset preeclampsia (less than 34 weeks of gestation). In the parent study, all women were treated with aspirin and then randomized to receive LMW heparin or aspirin alone...
December 4, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29215303/influence-of-cryopreservation-solution-on-the-in-vitro-culture-of-skin-tissues-derived-from-collared-peccary-pecari-tajacu-linnaeus-1758
#6
Alana A Borges, Gabriela P O Lira, Lucas E Nascimento, Luiza B Queiroz Neta, Maria V O Santos, Moacir F Oliveira, Alexandre R Silva, Alexsandra F Pereira
Skin vitrification is a promising and alternative tool for the conservation of biodiversity, especially for wild mammals, such as collared peccaries. Several factors can affect the success of this procedure, such as the cryoprotectant solution used. Therefore, this study was carried out to compare the efficiency of various vitrification solutions for recovery of viable cells after in vitro culture of cryopreserved skin tissues derived from the collared peccary, aiming to study the application in biobanking, where cellular use is not immediately required...
December 7, 2017: Biopreservation and Biobanking
https://www.readbyqxmd.com/read/29214412/gestational-age-at-birth-and-risk-of-intellectual-disability-without-a-common-genetic-cause
#7
Hein Heuvelman, Kathryn Abel, Susanne Wicks, Renee Gardner, Edward Johnstone, Brian Lee, Cecilia Magnusson, Christina Dalman, Dheeraj Rai
Preterm birth is linked to intellectual disability and there is evidence to suggest post-term birth may also incur risk. However, these associations have not yet been investigated in the absence of common genetic causes of intellectual disability, where risk associated with late delivery may be preventable. We therefore aimed to examine risk of intellectual disability without a common genetic cause across the entire range of gestation, using a matched-sibling design to account for unmeasured confounding by shared familial factors...
December 6, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/29212591/-pregnancy-after-bariatric-surgery
#8
Mette Mandrup Kjær, Lise Lotte Torvin-Andersen, Peter Dam, Dorte Møller Jensen, Jeanette Lauenborg, Louise Laage Stentebjerg, René Klinkeby Støving, Kristina Martha Renault
This is a review of the recommendations regarding pregnancy after bariatric surgery from the Danish Society of Obstetrics and Gynaecology. The risk of vitamin/mineral deficiencies should be emphasized and checked with blood samples. Measurements of fetal growth should be offered at gestational age 28 and 34 as a supplement to the standard prenatal procedures because of the increased risk of intrauterine growth retardation. Because of persistent obesity there is still an increased risk of hypertension and diabetes mellitus...
December 4, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29212571/expression-of-homeobox-gene-hlx-and-its-downstream-target-genes-are-altered-in-placentae-from-discordant-twin-pregnancies
#9
Nicola Yuen, Shaun P Brennecke, Mark P Umstad, Hannah E J Yong, Anthony J Borg, Gayathri Rajaraman, Bill Kalionis, Padma Murthi
A discordant twin gestation, in which one fetus is significantly growth restricted, compared to the other normal twin, is a unique model that can be used to elucidate the mechanism(s) by which the intrauterine environment affects fetal growth. In many model systems, placental transcription factor genes regulate fetal growth. Transcription factors regulate growth through their activation or repression of downstream target genes that mediate important cell functions. The objective of this study was to determine the expression of the placental HLX homeobox gene transcription factor and its downstream target genes in dizygotic twins with growth discordance...
December 7, 2017: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://www.readbyqxmd.com/read/29212472/autism-risk-classification-using-placental-chorionic-surface-vascular-network-features
#10
Jen-Mei Chang, Hui Zeng, Ruxu Han, Ya-Mei Chang, Ruchit Shah, Carolyn M Salafia, Craig Newschaffer, Richard K Miller, Philip Katzman, Jack Moye, Margaret Fallin, Cheryl K Walker, Lisa Croen
BACKGROUND: Autism Spectrum Disorder (ASD) is one of the fastest-growing developmental disorders in the United States. It was hypothesized that variations in the placental chorionic surface vascular network (PCSVN) structure may reflect both the overall effects of genetic and environmentally regulated variations in branching morphogenesis within the conceptus and the fetus' vital organs. This paper provides sound evidences to support the study of ASD risks with PCSVN through a combination of feature-selection and classification algorithms...
December 6, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/29211630/production-of-monoclonal-antibody-that-recognizes-zika-virus-and-other-flaviviruses-in-serum-free-conditions
#11
Fernando de Paiva Conte, Raquel de Souza Martins, Ana Carolina Dos Reis Albuquerque Cajaraville, Hilton Jorge Nascimento, Patricia Barbosa Jurgilas, Sheila Maria Barbosa de Lima, Sotiris Missailidis, Márcia Arissawa
With the recent outbreaks of Zika and Dengue virus infections in various countries worldwide, production of vaccines or diagnostic kits is an urgent public health demand. Production of a monoclonal antibody (mAb) that specifically binds to a common antigen shared by the Flavivirus genus will be necessary for new diagnostic kits or characterization and viral identity tests during vaccine development. This study aimed to cultivate, in serum-free conditions, the 4G2 hybridoma that produces an mAb, which recognizes a shared epitope from the Flavivirus genus...
December 6, 2017: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
https://www.readbyqxmd.com/read/29210999/adverse-intrauterine-environment-and-cardiac-mirna-expression
#12
REVIEW
Mitchell C Lock, Kimberley J Botting, Ross L Tellam, Doug Brooks, Janna L Morrison
Placental insufficiency, high altitude pregnancies, maternal obesity/diabetes, maternal undernutrition and stress can result in a poor setting for growth of the developing fetus. These adverse intrauterine environments result in physiological changes to the developing heart that impact how the heart will function in postnatal life. The intrauterine environment plays a key role in the complex interplay between genes and the epigenetic mechanisms that regulate their expression. In this review we describe how an adverse intrauterine environment can influence the expression of miRNAs (a sub-set of non-coding RNAs) and how these changes may impact heart development...
December 6, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29209605/the-effect-of-cigarette-smoking-during-pregnancy-on-endocrine-pancreatic-function-and-fetal-growth-a-pilot-study
#13
Fatima Lockhart, Anthony Liu, Bernard Linton Champion, Michael John Peek, Ralph Kay Heinrich Nanan, Alison Sally Poulton
Introduction: Cigarette smoking in pregnancy is a common cause of fetal growth restriction. We aimed to investigate endocrine pancreatic function of mother-infant dyads in relation to cigarette smoking, as a possible mechanism for the poor fetal growth. Methods: Prospective study of smoking mothers (10 cigarettes or more per day, self-reported to the midwife) and non-smoker control mothers during their first pregnancy. Insulin, glucose, C-peptide, HbA1C, fructosamine, prolactin, serotonin, and cortisol were measured in maternal blood at 24-26 weeks and in umbilical cord blood at birth...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/29209071/inhaled-nicotine-equivalent-to-cigarette-smoking-disrupts-systemic-and-uterine-hemodynamics-and-induces-cardiac-arrhythmia-in-pregnant-rats
#14
Xuesi M Shao, Héctor E López-Valdés, Jing Liang, Jack L Feldman
Maternal smoking with obligatory nicotine inhalation is associated with preterm delivery, low birth weight, fetal growth retardation and developmental defects. We tested the hypothesis that cigarette smoking-relevant nicotine inhalation during pregnancy impairs cardiovascular function and uterine hemodynamics with consequential fetal ischemia. Pregnant rats exposed to episodic inhaled nicotine via a novel lung alveolar region-targeted aerosol method produced nicotine pharmacokinetics resembling cigarette smoking in humans...
December 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29208602/impact-of-london-s-road-traffic-air-and-noise-pollution-on-birth-weight-retrospective-population-based-cohort-study
#15
Rachel B Smith, Daniela Fecht, John Gulliver, Sean D Beevers, David Dajnak, Marta Blangiardo, Rebecca E Ghosh, Anna L Hansell, Frank J Kelly, H Ross Anderson, Mireille B Toledano
Objective To investigate the relation between exposure to both air and noise pollution from road traffic and birth weight outcomes.Design Retrospective population based cohort study.Setting Greater London and surrounding counties up to the M25 motorway (2317 km2), UK, from 2006 to 2010.Participants 540 365 singleton term live births.Main outcome measures Term low birth weight (LBW), small for gestational age (SGA) at term, and term birth weight.Results Average air pollutant exposures across pregnancy were 41 μg/m3 nitrogen dioxide (NO2), 73 μg/m3 nitrogen oxides (NOx), 14 μg/m3 particulate matter with aerodynamic diameter <2...
December 5, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29208242/dna-methylation-of-amino-acid-transporter-genes-in-the-human-placenta
#16
C Simner, B Novakovic, K A Lillycrop, C G Bell, N C Harvey, C Cooper, R Saffery, R M Lewis, J K Cleal
INTRODUCTION: Placental transfer of amino acids via amino acid transporters is essential for fetal growth. Little is known about the epigenetic regulation of amino acid transporters in placenta. This study investigates the DNA methylation status of amino acid transporters and their expression across gestation in human placenta. METHODS: BeWo cells were treated with 5-aza-2'-deoxycytidine to inhibit methylation and assess the effects on amino acid transporter gene expression...
December 2017: Placenta
https://www.readbyqxmd.com/read/29208236/placental-abnormalities-differ-between-small-for-gestational-age-fetuses-in-dichorionic-twin-and-singleton-pregnancies
#17
Mia Kibel, Michael Kahn, Christopher Sherman, John Kingdom, Arthur Zaltz, Jon Barrett, Nir Melamed
OBJECTIVE: Twin fetuses grow slower during the third trimester compared with singletons. However, the extent to which the relative smallness of twins is the result of placenta-mediated factors similar to those associated with fetal growth restriction in singletons remains unclear. Our aim was to address this question by comparing placental findings between small for gestational age (SGA) twins and SGA singletons. METHODS: Retrospective cohort study of all SGA non-anomalous newborns from singleton and dichorionic twin pregnancies in a single tertiary referral center between 2002 and 2015...
December 2017: Placenta
https://www.readbyqxmd.com/read/29208172/investigation-of-role-of-vascular-endothelial-growth-factor-annexin-a5-and-apelin-by-immunohistochemistry-method-in-placenta-of-preeclampsia-patients
#18
Nese Colcimen, Gülay Bulut, Ozlem Ergul Erkec, Murat Cetin Ragbetli
Preeclampsia is a disease characterized by hypertension and proteinuria occurred after 20 weeks of gestation. Preeclampsia is a major cause of maternal and fetal morbidity and mortality.  The pathophysiological mechanism of preeclampsia is not known exactly yet. Preeclampsia endothelial cell dysfunction, associated with inadequate trophoblastic invasion is characterized by abnormal placentation. Vascular endothelial growth factor (VEGF) according to is an angiogenic cytokine, Annexin A5 is among endogenous peptides are both expressed from placental trophoblasts and Apelin is a multifunctional peptide and expressed by placental trophoblasts and endothelial cells...
November 30, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/29208068/in-vitro-supplementation-with-the-porcine-plasma-product-betagro%C3%A2-stimulates-activity-of-porcine-fetal-myoblasts-and-neonatal-satellite-cells-in-a-divergent-manner
#19
M A Vaughn, K J Phelps, J M Gonzalez
Two separate experiments were conducted to evaluate the effect of betaGRO® supplementation on in vitro porcine fetal myoblasts (PFM) and porcine satellite cells (PSC) proliferation, fusion and myotube thickness. The PFM and PSC were isolated from the m. longissimus dorsi of day 60 of gestation fetuses and piglets within 24 h of birth, respectively. Proliferation assays were conducted as 4×3 factorial arrangements with time of culture (24, 48, 72, 96 h) and media treatment (standard porcine media supplemented with 10% (vol/vol) fetal bovine serum (HS); HS without 10% fetal bovine serum (LS); and LS supplemented with 10 mg/ml betaGRO® (BG)) as main effects...
December 6, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/29207479/growth-and-bone-mineralization-of-very-preterm-infants-at-term-corrected-age-in-relation-to-different-nutritional-intakes-in-the-early-postnatal-period
#20
Michelle N Körnmann, Viola Christmann, Charlotte J W Gradussen, Laura Rodwell, Martin Gotthardt, Johannes B Van Goudoever, Arno F J Van Heijst
Preterm infants often have a reduced bone mineral content (BMC) with increased risk of metabolic bone disease. After birth it is difficult to supply calcium (Ca) and phosphorus (P) comparable to the high fetal accretion rate. It is not known whether high supplementation of minerals in the early postnatal period improves growth and bone mineralization. The aim of this study was to evaluate growth and bone mineralization at term corrected age (TCA) in very and extremely preterm infants who received different enteral Ca and P intakes during the first 10 days of life...
December 2, 2017: Nutrients
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