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https://www.readbyqxmd.com/read/29928934/study-on-the-developmental-toxicity-of-%C3%AE-ionone-in-the-rat
#1
Flávia C M Pinto, Rosangela R De-Carvalho, Ana Cecilia A X De-Oliveira, Isabella F Delgado, Francisco J R Paumgartten
β-ionone (BIO) is used in fragrances, toiletries and non-cosmetic products, and as a flavor food additive. Notwithstanding the widespread human exposure, there are limited data on the reproductive toxicity of BIO. This study evaluated the developmental toxicity of BIO (0, 125, 250, 500 and 1000 mg/kg body weight/day) given orally to rats on days 6-15 of gestation (GD6-15). C-section was on GD21 and implantations, living and dead fetuses and resorptions were recorded. Fetuses were weighed, and examined for external abnormalities and skeleton and visceral anomalies...
June 18, 2018: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29928930/effect-of-estetrol-a-selective-nuclear-estrogen-receptor-modulator-in-mouse-models-of-arterial-and-venous-thrombosis
#2
Marie-Cécile Valéra, Emmanuelle Noirrit-Esclassan, Marion Dupuis, Coralie Fontaine, Françoise Lenfant, Anne Briaux, Cendrine Cabou, Cedric Garcia, Olivier Lairez, Jean-Michel Foidart, Bernard Payrastre, Jean-François Arnal
Estetrol (E4) is a natural estrogen synthesized exclusively during pregnancy by the human fetal liver, and the physiological role of this hormone is unknown. Interestingly, E4 was recently evaluated in preclinical and phase II-III clinical studies in combination with a progestin, with the advantage to not increase the circulating level of coagulation factors, at variance to oral estradiol or ethinylestradiol. Here, we evaluated the effect of E4 on hemostasis and thrombosis in mouse. Following chronic E4 treatment, mice exhibited a prolonged tail-bleeding time and were protected from arterial and also venous thrombosis in vivo...
June 18, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29928900/characterization-and-comparison-of-human-limbal-explant-cultures-grown-under-defined-and-xeno-free-conditions
#3
Kristyna Brejchova, Peter Trosan, Pavel Studeny, Pavlina Skalicka, Tor Paaske Utheim, Jan Bednar, Katerina Jirsova
Human limbal epithelial cells (LECs) intended for treatment of limbal stem cell deficiency are commonly cultivated on a 3T3 feeder layer with complex culture medium supplemented with fetal bovine serum (FBS). However, FBS is a xenogeneic component containing poorly characterised constituents and exhibits quantitative and qualitative lot-to-lot variations. Human limbal explants were plated on untreated or fibrin coated plastic plates and cultured in two non-xenogeneic media (supplemented with either human serum or platelet lysate only)...
June 18, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29927665/maternal-reproductive-performance-and-fetal-development-of-the-wistar-audiogenic-rat-war-strain
#4
Eduardo H Umeoka, Matheus C Eiras, Iara G Viana, Vanessa S Giorgi, Aline Bueno, Débora C Damasceno, Norberto Garcia-Cairasco, Paula A Navarro
Wistar Audiogenic Rat (WAR) strain is an animal model for epilepsy studies, the chronic multifactorial disease that affects millions of people worldwide. The animals of this strain are genetically predisposed to sound-induced seizures, called audiogenic seizures, and have been used for many years in studies to understand the mechanisms involved in the epilepsies and their neuropsychiatric comorbidities, as well as the screening of potential anti-convulsant agents. Nevertheless, little is known about the reproductive characteristics of these animals...
June 21, 2018: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/29927503/increases-in-placental-nitric-oxide-but-not-nitric-oxide-mediated-relaxation-underlie-the-improvement-in-placental-efficiency-and-antihypertensive-effects-of-hydrogen-sulphide-donor-in-hypertensive-pregnancy
#5
Jose Sergio Possomato-Vieira, Jessica Sabbatine Chimini, Maria Luiza Santos da Silva, Carlos A Dias-Junior
Dysregulation of hydrogen sulphide (H2 S) producing enzymes has been related to hypertensive pregnancy and H2 S donor, sodium hydrosulphide (NaHS) exerts antihypertensive effects, modulates angiogenic factors production and acts as an antioxidant. Moreover, reduction in nitric oxide (NO) bioavailability is related to hypertensive pregnancy and H2 S may interact with NO, modulating its production. We aimed to investigate the NaHS effects in hypertension-in-pregnancy and also in feto-placental parameters. Female Wistar rats (200-250 g) were mated and desoxycorticosterone acetate injections followed by replacement of water by 0...
June 21, 2018: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29925850/consequences-of-in-utero-exposure-to-zika-virus-in-offspring-of-ag129-mice
#6
Justin G Julander, Venkatraman Siddharthan, Albert H Park, Elizabeth Preston, Pranav Mathur, Michael Bertolio, Hong Wang, Katherine Zukor, Arnaud J Van Wettere, Donal G Sinex, John D Morrey
Zika virus (ZIKV) can cause various diseases in offspring after congenital infection. The purpose of this study was to identify disease phenotypes in pups exposed to ZIKV in utero. Female interferon-α/β, -γ receptor knockout mice (AG129) were infected intraperitoneally with ZIKV 7.5 days' post coitus (dpc). Viral RNA, antigen and infectious virus were detected in some, but not all, maternal and fetal tissues at various times during gestation. Fetuses of infected dams had significant intrauterine growth restriction (IUGR), which was more pronounced as females neared parturition...
June 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29924631/effects-of-postweaning-calorie-restriction-on-accelerated-growth-and-adiponectin-in-nutritionally-programmed-microswine-offspring
#7
Elizabeth A DuPriest, Baoyu Lin, Philipp Kupfer, Kaiu Sekiguchi, Amruta Bhusari, Alexandra Quackenbush, Almir Celebic, Terry K Morgan, Jonathan Q Purnell, Susan Pound Bagby
Poor prenatal development followed by rapid childhood growth conveys greater cardiometabolic risk in later life. Microswine offspring exposed to perinatal maternal protein restriction (MPR; "low protein offspring", LPO) grow poorly in late-fetal/neonatal stages. After weaning to ad libitum (AL) diet, LPO-AL exhibit accelerated growth and fat deposition rates with low adiponectin mRNA despite low-normal body fat and small intra-abdominal adipocytes. We examined effects of caloric restriction (CR) on growth and metabolic status in LPO and normal protein offspring (NPO) randomized to AL or CR diets from weaning...
June 20, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29923311/primary-tissue-for-cellular-brain-repair-in-parkinson-s-disease-promise-problems-and-the-potential-of-biomaterials
#8
Niamh Moriarty, Clare L Parish, Eilís Dowd
The dopamine precursor, levodopa, remains the 'gold-standard' treatment for Parkinson's disease, and, although it provides superlative efficacy in the early stages of the disease, its long-term use is limited by the development of severe motor side effects and a significant abating of therapeutic efficacy. Therefore, there remains a major unmet clinical need for the development of effective neuroprotective, neurorestorative or neuroreparatory therapies for this condition. The relatively selective loss of dopaminergic neurons from the nigrostriatal pathway makes Parkinson's disease an ideal candidate for reparative cell therapies wherein the dopaminergic neurons that are lost in the condition are replaced through direct cell transplantation into the brain...
June 20, 2018: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29921677/impact-of-parental-weight-status-on-children-s-body-mass-index-in-early-life-evidence-from-a-chinese-cohort
#9
Hong Mei, Siyu Guo, Hongyan Lu, Yunhong Pan, Wenhua Mei, Bin Zhang, Jianduan Zhang
OBJECTIVES: To understand whether parents' weight status before conception predicts body mass index (BMI) of their offspring in early life and the differences between the mother-child and father-child associations. DESIGN: A birth cohort study. SETTING: Conducted at the Community Health Service Centre in Shenyang, Wuhan and Guangzhou. PARTICIPANTS: A total of 2220 live birth newborns were recruited randomly after consent of their parents, and 1178 were followed up until 2 years old...
June 19, 2018: BMJ Open
https://www.readbyqxmd.com/read/29920825/prediction-of-preterm-delivery-in-symptomatic-women-using-placental-alpha-microglobulin-1-fetal-fibronectin-and-phosphorylated-insulin-like-growth-factor-binding-protein-1-tests-systematic-review-and-meta-analysis-stratified-by-risk
#10
REVIEW
Juan Carlos Melchor, Asma Khalil, Deborah Wing, Ekkehard Schleussner, Daniel Surbek
OBJECTIVE: To assess the diagnostic accuracy of placental alpha- microglobulin-1 (PAMG-1), fetal fibronectin (fFN), and phosphorylated insulin-like growth factor-binding protein-1 (phIGFBP-1) tests in the prediction of spontaneous preterm birth in women with symptoms of preterm labor within 7 days (sPTB≤7d) of testing using formal methods for systematic review. Further analysis looking into performance in low, intermediate and high-risk patient groups. METHODS: Two reviewers independently searched the Cochrane, MEDLINE, PubMed and ResearchGate bibliographic databases...
June 19, 2018: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29920817/predictive-accuracy-of-cerebroplacental-ratio-for-adverse-perinatal-and-neurodevelopmental-outcomes-in-suspected-fetal-growth-restriction-systematic-review-and-meta-analysis
#11
REVIEW
Agustin Conde-Agudelo, José Villar, Stephen H Kennedy, Aris T Papageorghiou
OBJECTIVE: The cerebroplacental ratio (CPR) has been proposed for the routine surveillance of pregnancies with suspected fetal growth restriction (FGR), but the predictive performance of this test is unclear. The aim of this study was to determine the accuracy of the CPR for predicting adverse perinatal and neurodevelopmental outcomes in suspected FGR. METHODS: PubMed, EMBASE, CINAHL, and Lilacs (all from inception to July 31, 2017) were searched for cohort or cross-sectional studies that reported on the accuracy of the CPR for predicting adverse perinatal and/or neurodevelopmental outcomes in singleton pregnancies with antenatally suspected FGR based on sonographic parameters...
June 19, 2018: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29920141/predictive-value-of-maternal-serum-biomarkers-for-preeclampsia-and-birth-weight-a-case-control-study-in-chinese-pregnant-women
#12
Li-Juan Sun, Gu-Feng Xu, Min Lv, Hao Zhou, He-Feng Huang, Qiong Luo
BACKGROUND: In clinical practice, abnormal biochemical changes often occur in women who eventually develop preeclampsia (PE). The study aims to investigate whether maternal serum biochemical markers in the early third trimester can predict PE and neonatal birth weight. STUDY DESIGN: A retrospective case-control study was performed on 287 women who subsequently developed PE (mild = 139; severe = 148) and 143 healthy women. Fasting venous blood samples of all gravidas were drawn for routine biochemical markers screening in the early third trimester (28...
June 19, 2018: Journal of Women's Health
https://www.readbyqxmd.com/read/29915318/low-affinity-nerve-growth-factor-receptor-cd271-heterogeneous-expression-in-adult-and-fetal-mesenchymal-stromal-cells
#13
Mario Barilani, Federica Banfi, Silvia Sironi, Enrico Ragni, Salomé Guillaumin, Francesca Polveraccio, Lorenzo Rosso, Monica Moro, Giuseppe Astori, Michela Pozzobon, Lorenza Lazzari
Human multipotent mesenchymal stromal cells (MSC) are isolated from a plethora of tissue sources for cell therapy purposes. In 2006, the International Society for Cellular Therapy (ISCT) published minimal guidelines to define MSC identity. Nevertheless, many independent studies demonstrated that cells meeting the ISCT criteria possessed heterogeneous phenotypes and functionalities, heavily influenced by culture conditions. In this study, human MSC derived from many adult (bone marrow and adipose tissue) or fetal (cord blood, Wharton's jelly, umbilical cord perivascular compartment and amniotic fluid) tissues were investigated...
June 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29913544/uterine-artery-doppler-in-screening-for-preeclampsia-and-fetal-growth-restriction
#14
Marianna Amaral Pedroso, Kirsten Rebecca Palmer, Ryan James Hodges, Fabricio da Silva Costa, Daniel Lorber Rolnik
OBJECTIVE:  To perform a comprehensive review of the current evidence on the role of uterine artery Doppler, isolated or in combination with other markers, in screening for preeclampsia (PE) and fetal growth restriction (FGR) in the general population. The review included recently published large cohort studies and randomized trials. METHODS:  A search of the literature was conducted using Medline, PubMed, MeSH and ScienceDirect. Combinations of the search terms "preeclampsia," "screening," "prediction," "Doppler," "Doppler velocimetry," "fetal growth restriction," "small for gestational age" and "uterine artery" were used...
May 2018: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/29912342/reply-excessive-fetal-growth-in-frozen-embryo-transfer-false-alarm-or-clinical-concern
#15
Abha Maheshwari, Mark Hamilton, Asha Shetty, Edwin Amalraj Raja, Siladitya Bhattacharya
No abstract text is available yet for this article.
April 18, 2018: Human Reproduction Update
https://www.readbyqxmd.com/read/29912325/excessive-fetal-growth-in-frozen-embryo-transfer-false-alarm-or-clinical-concern
#16
Edgardo Somigliana, Valeria Stella Vanni, Andrea Busnelli, Marco Reschini, Enrico Papaleo, Paola Viganò
No abstract text is available yet for this article.
April 18, 2018: Human Reproduction Update
https://www.readbyqxmd.com/read/29911034/fetal-skeletal-size-and-growth-are-relevant-biometric-markers-in-vitamin-d-deficient-mothers-a-north-east-india-prospective-cohort-study
#17
Dipti Sarma, Uma K Saikia, Darvin V Das
Context: The neonatal skeletal outcomes due to maternal Vitamin D deficiency. Aims: The aim of this study is to assess the serum 25 hydroxy Vitamin D (25[OH]D) status in pregnant women and correlate with cord blood 25(OH)D levels, femur length at 34 weeks gestation, and neonatal anthropometry (birth weight, birth length, and head circumference). Settings and Design: This was prospective cohort study. Subjects and Methods: This study was carried out in 250 healthy primigravida between 18 and 40 years of age in the third trimester of gestation attending the Obstetrics and Gynaecology Department of Gauhati Medical College, Guwahati from December 2012 to December 2015...
March 2018: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29910107/maternal-sleep-during-pregnancy-and-poor-fetal-outcomes-a-scoping-review-of-the-literature-with-meta-analysis
#18
REVIEW
Jane Warland, Jillian Dorrian, Janna L Morrison, Louise M O'Brien
There is a wealth of evidence to say that sleep impacts maternal health during pregnancy, however, little has been published on fetal health and maternal sleep. This scoping review summarises current literature on maternal sleep including sleep disordered breathing, sleep quality, sleep duration and supine sleep position, as these relate to fetal outcomes specifically birth weight, growth, preterm birth and stillbirth. An overall interpretation of the studies evaluated shows that events occurring during maternal sleep such as obstructive sleep apnea, sleep disruption and sleep position may have a negative effect on the fetus resulting in altered growth, gestational length and even death...
March 27, 2018: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/29909950/-management-of-mitral-valve-stenosis-during-pregnancy-at-the-oran-university-hospital-center-about-83-cases
#19
N F Benatta, D D Batouche, M A Djazouli, S A Zelmat, T Merzouk, L Hammou
INTRODUCTION: The management of pregnancy in patients with mitral valve stenosis disease continues to pose a challenge to the clinician. OBJECTIVE: The aim of study was to evaluate the association between mitral valve stenosis and maternal and fetal out come. MATERIEL AND METHOD: Eighty-three pregnant women with mitral valve disease, followed-up from 2009 to 2012, were prospectively evaluated medical history, NYHA class assessment, ECG and echocardiography were performed during pregnancy and after delivery...
June 14, 2018: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/29909700/the-significant-role-of-amino-acids-during-pregnancy-nutritional-support
#20
Penelope D Manta-Vogli, Kleopatra H Schulpis, Yannis Dotsikas, Yannis L Loukas
BACKGROUND: Pregnancy is characterized by a complexity of metabolic processes that may impact fetal development and infant health outcome. Normal fetal growth and development depend on a continuous supply of nutrients via the placenta. The placenta transports, utilizes, produces and interconverts amino acids (AAs). FINDINGS: Concentrations of both nonessential and essential AAs in maternal plasma decrease in early pregnancy and persist at low concentrations throughout...
June 18, 2018: Journal of Maternal-fetal & Neonatal Medicine
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