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https://www.readbyqxmd.com/read/29444501/quercetin-therapy-for-selected-patients-with-pim1-kinase-positive-chronic-lymphocytic-leukemia-small-lymphocytic-lymphoma-a-pilot-study
#1
Beverly W Baron, Michael J Thirman, Mihai C Giurcanu, Joseph M Baron
We reported that PIM1 kinase is expressed in the lymphocytes of patients with chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL). Quercetin, a naturally occurring flavonoid, is a dietary supplement and inhibits many kinases, including PIM1, in vitro. Under an Institutional Review Board-approved protocol, we performed an open-label, single-arm pilot study to evaluate the antitumor activity of quercetin in patients with CLL/SLL. Q-ForceTM chews were administered orally, 500 mg twice daily, for 3 months...
February 14, 2018: Acta Haematologica
https://www.readbyqxmd.com/read/29444377/a-biomechanical-analysis-of-prognathous-and-orthognathous-insect-head-capsules-evidence-for-a-many-to-one-mapping-of-ridge-strain-to-head-strain
#2
Alexander Blanke, Manuel Pinheiro, Peter J Watson, Michael J Fagan
Insect head shapes are remarkably variable but the influences of these changes on biomechanical performance are unclear. Among "basal" winged insects, such as dragonflies, mayflies, earwigs, and stoneflies, some of the most prominent anatomical changes are the general mouthpart orientation, eye size and the connection of the endoskeleton to the head. Here, we assess these variations as well as differing ridge and sclerite configurations using modern engineering methods including multibody dynamics modelling and finite element analysis in order to quantify and compare the influence of anatomical changes on strain in particular head regions and the whole head...
February 14, 2018: Journal of Evolutionary Biology
https://www.readbyqxmd.com/read/29444174/chromosome-evolution-in-cophomantini-amphibia-anura-hylinae
#3
Juan M Ferro, Dario E Cardozo, Pablo Suárez, Juan M Boeris, Ailin Blasco-Zúñiga, Gastón Barbero, Anderson Gomes, Thiago Gazoni, William Costa, Cleusa Y Nagamachi, Miryan Rivera, Patricia P Parise-Maltempi, John E Wiley, Julio C Pieczarka, Celio F B Haddad, Julián Faivovich, Diego Baldo
The hylid tribe Cophomantini is a diverse clade of Neotropical treefrogs composed of the genera Aplastodiscus, Boana, Bokermannohyla, Hyloscirtus, and Myersiohyla. The phylogenetic relationships of Cophomantini have been comprehensively reviewed in the literature, providing a suitable framework for the study of chromosome evolution. Employing different banding techniques, we studied the chromosomes of 25 species of Boana and 3 of Hyloscirtus; thus providing, for the first time, data for Hyloscirtus and for 15 species of Boana...
2018: PloS One
https://www.readbyqxmd.com/read/29444171/reduced-cognitive-function-increased-blood-brain-barrier-transport-and-inflammatory-responses-and-altered-brain-metabolites-in-ldlr-and-c57bl-6-mice-fed-a-western-diet
#4
Jennifer M Rutkowsky, Linda L Lee, Michelle Puchowicz, Mari S Golub, Douglas E Befroy, Dennis W Wilson, Steven Anderson, Gary Cline, Jason Bini, Kamil Borkowski, Trina A Knotts, John C Rutledge
Recent work suggests that diet affects brain metabolism thereby impacting cognitive function. Our objective was to determine if a western diet altered brain metabolism, increased blood-brain barrier (BBB) transport and inflammation, and induced cognitive impairment in C57BL/6 (WT) mice and low-density lipoprotein receptor null (LDLr -/-) mice, a model of hyperlipidemia and cognitive decline. We show that a western diet and LDLr -/- moderately influence cognitive processes as assessed by Y-maze and radial arm water maze...
2018: PloS One
https://www.readbyqxmd.com/read/29444105/accuracy-and-precision-of-consumer-level-activity-monitors-for-stroke-detection-during-wheelchair-propulsion-and-arm-ergometry
#5
Jochen Kressler, Joshua Koeplin-Day, Benedikt Muendle, Brice Rosby, Elizabeth Santo, Antoinette Domingo
The purpose of this study was to evaluate whether consumer-level activity trackers can estimate wheelchair strokes and arm ergometer revolutions. Thirty able-bodied participants wore three consumer-level activity trackers (Garmin VivoFit, FitBit Flex, and Jawbone UP24) on the wrist. Participants propelled a wheelchair at fixed frequencies (30, 45 and 60 strokes per minute (spm)) three minutes each and at pre-determined varied frequencies, (30-80 spm) for two minutes. Participants also freely wheeled through an obstacle course...
2018: PloS One
https://www.readbyqxmd.com/read/29444018/recovering-a-hidden-polarization-by-ghost-polarimetry
#6
Patrick Janassek, Sébastien Blumenstein, Wolfgang Elsäßer
By exploiting polarization correlations of light from a broadband fiber-based amplified spontaneous emission source we succeed in reconstructing a hidden polarization in a ghost polarimetry experiment in close analogy to ghost imaging and ghost spectroscopy. Thereby, an original linear polarization state in the object arm of a Mach-Zehnder interferometer configuration which has been camouflaged by a subsequent depolarizer is recovered by correlating it with light from a reference beam. The variation of a linear polarizer placed inside the reference beam results in a Malus law type second-order intensity correlation with high contrast, thus measuring a ghost polarigram...
February 15, 2018: Optics Letters
https://www.readbyqxmd.com/read/29443766/meta-analysis-study-comparing-percutaneous-coronary-intervention-drug-eluting-stent-versus-coronary-artery-bypass-surgery-of-unprotected-left-main-coronary-artery-disease-clinical-outcomes-during-short-term-versus-long-term-1-year-follow-up
#7
Waleed E Ali, Satyanarayana R Vaidya, Sylvester U Ejeh, Kingsley U Okoroafor
BACKGROUND: Results on the safety and long-term efficacy of drug-eluting stent placement in unprotected left main coronary artery disease (ULMCAD) compared with those of coronary artery bypass surgery (CABG) remain inconsistent across randomized clinical trials and recent meta-analysis studies. We aimed to compare the clinical outcomes and safety over short- and long-term follow-ups by conducting a meta-analysis of large pooled data from randomized controlled trials and up-to-date observational studies...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29443557/adolescent-pregnancy-prevention-among-youths-living-in-group-care-homes-a-cluster-randomized-controlled-trial
#8
Roy F Oman, Sara K Vesely, Jennifer Green, Kristen Clements-Nolle, Minggen Lu
OBJECTIVES: To determine if the Power Through Choices (PTC) intervention can increase the use of birth control and reduce pregnancy among system-involved youths living in group care homes. METHODS: We performed a 2-arm cluster randomized controlled trial involving group care homes operated by child welfare or juvenile justice systems in California, Maryland, and Oklahoma with assessments immediately before and after the intervention, and at 6- and 12-month follow-up...
February 2018: American Journal of Public Health
https://www.readbyqxmd.com/read/29443445/aspirin-withdrawal-in-patients-treated-with-ticagrelor-presenting-with-non-st-elevation-myocardial-infarction
#9
Roy Beigel, Israel Mazin, Edward Koifman, Michael Shechter, Hanna Pres, Nir Shlomo, Nurit Rosenberg, Elad Asher, Shlomi Matetzky
BACKGROUND: Recent studies have shown that the thromboxaneA 2 -dependent pathway is dependent upon the adenosine diphosphate (ADP)-P2Y 12 pathway and that strong P2Y 12 receptor blockade alone causes inhibition of platelet aggregation that is minimally enhanced by aspirin. Data from the PLATO trial suggested that among ticagrelor-treated patients, high compared with low dose (<100mg\day) aspirin is associated with increased risk for ischemic events. OBJECTIVES: In the current prospective, randomized, placebo-controlled, double-blind, cross-over study, we sought to evaluate the impact of aspirin withdrawal on platelet reactivity in acute coronary syndrome (ACS) patients treated with a potent P2Y 12 blocker...
February 14, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29443395/subcutaneous-infusion-of-fluids-for-hydration-or-nutrition-a-review
#10
REVIEW
Riccardo Caccialanza, Thierry Constans, Paolo Cotogni, Gary P Zaloga, Alessandro Pontes-Arruda
Subcutaneous infusion, or hypodermoclysis, is a technique whereby fluids are infused into the subcutaneous space via small-gauge needles that are typically inserted into the thighs, abdomen, back, or arms. In this review, we provide an overview of the technique, summarize findings from studies that have examined the use of subcutaneous infusion of fluids for hydration or nutrition, and describe the indications, advantages, and disadvantages of subcutaneous infusion. Taken together, the available evidence suggests that, when indicated, subcutaneous infusion can be effective for administering fluids for hydration or nutrition, with minimal complications, and has similar effectiveness and safety to the intravenous route...
February 2018: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29442557/reference-frames-in-the-decisions-of-hand-choice
#11
Romy S Bakker, Luc P J Selen, W Pieter Medendorp
For the brain to decide on a reaching movement, it needs to select which hand to use. A number of body-centered factors affect this decision, such as the anticipated movement costs of each arm, recent choice success, handedness, and task demands. While the relative position of each hand to the target is also known to be an important spatial factor, it is unclear which reference frames coordinate the spatial aspects in the decisions of hand choice. Here, we tested the role of gaze- and head-centered reference frames in a hand selection task...
February 14, 2018: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29442401/single-arm-phase-ii-study-of-oral-vitamin-b12-for-the-treatment-of-musculoskeletal-symptoms-associated-with-aromatase-inhibitors-in-women-with-early-stage-breast-cancer
#12
Aleli Campbell, Rosalinda Heydarian, Cecilia Ochoa, Alok Kumar Dwivedi, Zeina A Nahleh
Breast cancer patients receiving endocrine therapy with aromatase Inhibitors (AIs) often experience musculoskeletal and joint-related side effects. The purpose of this study was to evaluate the effect of Vitamin B12 supplements on musculoskeletal symptoms such as pain and arthralgias induced by AIs and to correlate response with serum and inflammatory biomarkers. Upon receiving approval by the Institutional Review Board (IRB), the majority of the patients consented into the study were treated at the Texas Tech Breast Care Center...
February 14, 2018: Breast Journal
https://www.readbyqxmd.com/read/29442239/randomized-double-blind-clinical-trial-of-combined-treatment-with-megestrol-acetate-plus-celecoxib-versus-megestrol-acetate-alone-in-cachexia-anorexia-syndrome-induced-by-gi-cancers
#13
Bizhan Kouchaki, Ghasem Janbabai, Abbas Alipour, Shahram Ala, Samaneh Borhani, Ebrahim Salehifar
PURPOSE: Previous studies reported promising efficacy for celecoxib in the treatment of cancer cachexia. We designed this study to test the hypothesis that combination therapy with megestrol acetate (MA) plus celecoxib is superior to MA alone. METHODS: Ninety eligible gastrointestinal cancer patients randomly received either MA 320 mg/day plus placebo (arm1) or MA 320 mg/day plus celecoxib 200 mg/day (arm2). Patients were evaluated at baseline, then 1 and 2 months after starting interventions...
February 13, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29442159/open-reduction-and-fixation-with-a-locking-plate-without-bone-grafting-is-a-reasonable-and-safe-option-for-treating-proximal-humerus-nonunion
#14
Stefan Quadlbauer, Georg J Hofmann, Martin Leixnering, Rudolf Rosenauer, Thomas Hausner, Jürgen Reichetseder
AIM OF THE STUDY: The aim of this study was to evaluate union rate and clinical outcome in patients with proximal humeral nonunions treated by open reduction and locking plate fixation without bone grafting. METHODS: From 2011 to 2016, nine patients were treated using open reduction and locking plate stabilization without bone grafting. They were examined both clinically and radiologically, with a mean follow-up period of 31 months. Outcome was evaluated using pain and range of motion (ROM) parameters...
February 13, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29441577/can-a-gender-equity-and-family-planning-intervention-for-men-change-their-gender-ideology-results-from-the-charm-intervention-in-rural-india
#15
Paul J Fleming, Jay Silverman, Mohan Ghule, Julie Ritter, Madhusudana Battala, Gajanan Velhal, Saritha Nair, Anindita Dasgupta, Balaiah Donta, Niranjan Saggurti, Anita Raj
We assess the effect of CHARM, a gender equity and family planning counseling intervention for husbands in rural India, on men's gender ideology. We used a two-armed cluster randomized control trial design and collected survey data from husbands (n=1081) at baseline, 9 months, and 18 months. We used a continuous measure of support for gender equity and a dichotomous measure of equitable attitudes toward women's role in household decision-making. To assess differences on these outcomes, we used generalized linear mixed models...
February 14, 2018: Studies in Family Planning
https://www.readbyqxmd.com/read/29441470/early-manifestation-of-arm-leg-coordination-during-stepping-on-a-surface-in-human-neonates
#16
Valentina La Scaleia, Y Ivanenko, A Fabiano, F Sylos-Labini, G Cappellini, S Picone, P Paolillo, A Di Paolo, F Lacquaniti
The accomplishment of mature locomotor movements relies upon the integrated coordination of the lower and upper limbs and the trunk. Human adults normally swing their arms and a quadrupedal limb coordination persists during bipedal walking despite a strong corticospinal control of the upper extremities that allows to uncouple this connection during voluntary activities. Here we investigated arm-leg coordination during stepping responses on a surface in human neonates. In eight neonates, we found the overt presence of alternating arm-leg oscillations, the arms moving up and down in alternation with ipsilateral lower limb movements...
February 13, 2018: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/29441469/gaze-anchoring-guides-real-but-not-pantomime-reach-to-grasp-support-for-the-action-perception-theory
#17
Jessica R Kuntz, Jenni M Karl, Jon B Doan, Ian Q Whishaw
Reach-to-grasp movements feature the integration of a reach directed by the extrinsic (location) features of a target and a grasp directed by the intrinsic (size, shape) features of a target. The action-perception theory suggests that integration and scaling of a reach-to-grasp movement, including its trajectory and the concurrent digit shaping, are features that depend upon online action pathways of the dorsal visuomotor stream. Scaling is much less accurate for a pantomime reach-to-grasp movement, a pretend reach with the target object absent...
February 13, 2018: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/29441106/mid-upper-arm-circumference-as-a-screening-measure-for-identifying-children-with-elevated-body-mass-index-a-study-for-pakistan
#18
Muhammad Asif, Muhammad Aslam, Saima Altaf
Purpose: Mid-upper-arm circumference (MUAC) is considered an alternative screening method for obesity. The aims of this investigation were to examine the ability of MUAC to correctly identify children with elevated body mass index (BMI) and to determine the best MUAC cutoff point for identification of children with high BMI. Methods: Anthropometric measurements (height, weight, and MUAC) from a cross-sectional sample of 7,921 Pakistani children aged 5-14 years were analyzed...
January 2018: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/29440859/nevus-comedonicus-on-scalp-an-unusual-presentation
#19
Priyadarshini Sahu, Kamal Aggrawal, Chetna Bansal, V K Jain
Nevus comedonicus (NC) is a rare developmental anomaly of follicular infundibulum plugged with keratinous material that resembles comedo-like lesions. Frequently affected sites are face, neck, trunk, and upper arm. Few cases have been described on palms, soles, scalp, and genitalia. We hereby report a rare case of NC on scalp in a 14-year-old boy.
January 2018: International Journal of Trichology
https://www.readbyqxmd.com/read/29440819/intravenous-lignocaine-infusion-for-intractable-pain-in-ewing-s-sarcoma
#20
Nivedita Page
A 23-year-old female presented to our palliative care center with Ewing's sarcoma of the humerus with lung metastases. Pain in her arm was unrelieved by nonsteroidal anti-inflammatory drugs, neuropathic medication as well as morphine. She could not tolerate any further increase in opioid dose but was so distraught due to the pain that she wanted to die. An intravenous lignocaine infusion in a dose of 2 mg/kg was given over an hour for three successive days. This successfully relieved her pain after which she was settled with her original medication...
January 2018: Indian Journal of Palliative Care
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