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Joaquin Mateo, Heather H Cheng, Himisha Beltran, David Dolling, Wen Xu, Colin C Pritchard, Helen Mossop, Pasquale Rescigno, Raquel Perez-Lopez, Verena Sailer, Michael Kolinsky, Ada Balasopoulou, Claudia Bertan, David M Nanus, Scott T Tagawa, Heather Thorne, Bruce Montgomery, Suzanne Carreira, Shahneen Sandhu, Mark A Rubin, Peter S Nelson, Johann S de Bono
BACKGROUND: Germline DNA damage repair gene mutation (gDDRm) is found in >10% of metastatic prostate cancer (mPC). Their prognostic and predictive impact relating to standard therapies is unclear. OBJECTIVE: To determine whether gDDRm status impacts benefit from established therapies in mPC. DESIGN, SETTING, AND PARTICIPANTS: This is a retrospective, international, observational study. Medical records were reviewed for 390 mPC patients with known gDDRm status...
January 29, 2018: European Urology
Tinisha L Mayo, Tracy E Spinks, Seohyun Lee, Carlos Hernando Barcenas, Benjamin D Smith, Sharon Hermes Giordano, Rosa F Hwang, Richard A Ehlers, Jesse C Selber, Ronald Stewart Walters, Debu Tripathy, Kelly Hunt, Thomas A Buchholz, Thomas W Feeley, Henry Mark Kuerer
16 Background: Value in healthcare (patient-centered outcomes achieved per dollar spent) unifies performance improvement goals with health outcomes of importance to patients. We describe the process through which value-based measures for breast cancer patients and dynamic capture of these metrics via our new electronic health record (EHR) were developed at our institution. METHODS: A review of the breast cancer literature was conducted on treatment options as well as expected outcomes and potential treatment complications...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Tomas J Saun, Scott Odorizzi, Celine Yeung, Marjorie Johnson, Glen Bandiera, Shelly P Dev
OBJECTIVE: Online medical education resources are becoming an increasingly used modality and many studies have demonstrated their efficacy in procedural instruction. This study sought to determine whether a standardized online procedural video is as effective as a standard recorded didactic teaching session for chest tube insertion. DESIGN: A randomized control trial was conducted. Participants were taught how to insert a chest tube with either a recorded didactic teaching session, or a New England Journal of Medicine (NEJM) video...
May 2017: Journal of Surgical Education
L M Perrem, S Gosling, I Ravikumar, A S Khashan, J Miletin, C A Ryan, E Dempsey
AIM: To evaluate the reported use of data monitoring committees (DMCs), the frequency of interim analysis, prespecified stopping rules and early trial termination in neonatal randomised controlled trials (RCTs). METHODS: We reviewed neonatal RCTs published in four high-impact general medical journals, specifically looking at safety issues including documented involvement of a DMC, stated interim analysis, stopping rules and early trial termination. We searched all journal issues over an 11-year period (2003-2013) and recorded predefined parameters on each item for RCTs meeting inclusion criteria...
January 2017: Acta Paediatrica
(no author information available yet)
No abstract text is available yet for this article.
July 28, 2016: New England Journal of Medicine
B Cosmi, C Legnani, A Ghirarduzzi, V De Micheli, V Pengo, S Testa, D Poli, E Antonucci, D Prisco, A Tripodi, P Prandoni, G Palareti
INTRODUCTION: Idiopathic venous thromboembolism (VTE) is associated with the risk of cancer but the risk factors for cancer development in such patients are still uncertain. AIM: To assess risk factors for the development of cancer after a standard course of anticoagulation in patients with first episode of idiopathic VTE. MATERIALS AND METHODS: Subjects were enrolled in the three large prospective multicentre studies: PROLONG (NEJM 2006) PROLONG II (Blood 2010) and DULCIS (Blood 2014)...
April 2016: Thrombosis Research
Paula F Wrafter, Tara M Connelly, Jody Khan, Liam Devane, John Kelly, William P Joyce
PURPOSE: Bibliometric analysis highlights the key topics and studies which have led to the current understanding and treatment of a disease of interest. In this original article we analyze the 100 most cited manuscripts in the field of colorectal cancer (CRC). MATERIALS AND METHODS: The Thomson Reuters Web of Science database with the search terms 'colorectal cancer,' 'colorectal cancer surgery,' 'colon cancer,' 'rectal cancer,' 'colorectal carcinoma,' 'colon carcinoma,' 'rectal carcinoma' and/or 'colonoscopy' was used to identify the manuscripts for the study...
December 2016: Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
(no author information available yet)
New England Journal of Medicine, Volume 372, Issue 21, Page 2074-2074, May 2015.
May 21, 2015: New England Journal of Medicine
(no author information available yet)
New England Journal of Medicine, Volume 372, Issue 15, Page 1478-1478, April 2015.
April 9, 2015: New England Journal of Medicine
(no author information available yet)
Case 26-2014: A 21-Month-Old Boy with Lethargy, Respiratory Distress, and Abdominal Distention Case Records of the Massachusetts General Hospital, N Engl J Med 2014;371:767-773. In the Renal Management and Follow-up section (page 772), in the first sentence of the fourth paragraph, the molecular mass mentioned parenthetically should have been 138 D, rather than 138 kD. The article is correct at
April 9, 2015: New England Journal of Medicine
Jose C da Silva, Fulvio A Scorza, Mariana B Nejm, Esper A Cavalheiro, Arthur Cukiert
OBJECTIVES: We studied the effects of Hip-deep brain stimulation (DBS) on the expression of the inducible transcription factor c-FOS in the brain of normal rats. MATERIALS AND METHODS: Ten Wistar rats were anesthetized, and nine were implanted with epidural and hippocampal electrodes for brain activity recording; one animal was used as sham. Bipolar stimulating electrodes were implanted in the left hippocampus. Three animals were used as control (implanted but not stimulated), one as sham (not implanted, not stimulated), and six as the study group...
April 2014: Neuromodulation: Journal of the International Neuromodulation Society
Isaac S Kohane, Jeffrey M Drazen, Edward W Campion
Over the past year, the Journal has commemorated 200 years of publication and the astonishing progress made since 1812 in the science and practice of medicine. Thanks to digital technology, our anniversary celebration has had a wide reach, with more than 1 million visits to the
December 27, 2012: New England Journal of Medicine
George C M Siontis, John P A Ioannidis
BACKGROUND: Large studies may identify postulated risk factors and interventions with very small effect sizes. We aimed to assess empirically a large number of statistically significant relative risks (RRs) of tiny magnitude and their interpretation by investigators. METHODS: RRs in the range between 0.95 and 1.05 were identified in abstracts of articles of cohort studies; articles published in NEJM, JAMA or Lancet; and Cochrane reviews. For each eligible tiny effect and the respective study, we recorded information on study design, participants, risk factor/intervention, outcome, effect estimates, P-values and interpretation by study investigators...
October 2011: International Journal of Epidemiology
Edward W Campion, Lisa Scott, Cynthia Bowab, Sara Fleming, Theodore J Blizzard, Christine Lamb, Thomas J Easley, Jeffrey M Drazen
Each week, half a million readers access the Journal electronically, and our content is now seen online by about four times as many people as those who see the print edition. This mode of information delivery has expanded tremendously since the Journal first went online in 1996.(1) Not so long ago, electronic publishing was viewed as secondary to print publication, basically as a convenient way to deliver the print version of an article. Today, the electronic presentation of scientific articles has become the version of record, with print becoming only one part of the complete publication, which may include video, ...
August 12, 2010: New England Journal of Medicine
Esther Calbo, Anna Ochoa de Echagüen, Mónica Rodríguez-Carballeira, Carles Ferrer, Javier Garau
INTRODUCTION: The objective of this study was to evaluate the management of community acquired pneumonia (CAP) according to conventional clinical criteria applied in the emergency room as compared to a pneumonia prognosis index (PPI) (Fine et al. NEJM 1997). We also analyzed which factors were associated with the need for inpatient treatment in PPI risk category III patients. METHODS: We prospectively enrolled all adults with CAP seen in the emergency room during 1999...
February 2004: Enfermedades Infecciosas y Microbiología Clínica
Sherali A Rahim, Akbar Panju, Menaka Pai, Jeffrey Ginsberg
BACKGROUND: Venous thromboembolic disease (VTE) is a major cause of morbidity and mortality in hospitalized patients. Most hospitalized patients with a fatal pulmonary embolism are medical patients who do not have a history of recent surgery [BMJ 302 (1991) 709; J. R. Soc. Med. 82 (1989) 198]. There is evidence suggesting that VTE prophylaxis is indicated in many high risk medical patients [Chest 119 (2001) 132S; NEJM 341 (1999) 793]. However, previous studies have shown that only about one third of high risk medical patients receive VTE prophylaxis [Ann...
2003: Thrombosis Research
G P McDonald, D P Pendarvis, R Wilmoth, B J Daley
The frequency of computed tomography (CT) ordered by emergency department physicians at our facility was noted to sharply increase in early 1998 after a New England Journal of Medicine (NEJM) article recommending routine CT in patients with suspected appendicitis. Numerous studies have proven the accuracy of CT for detecting acute appendicitis; however, the most appropriate use of CT continues to evolve. We sought to evaluate the effect of increased CT use on negative appendectomy rate and perforation rate at our institution and to better delineate in whom CT is most beneficial...
November 2001: American Surgeon
Swartz, Jackson, Lang, Ecker, Ganiats, Dickinson, Nguyen
Objective: The search for quality, cost-effective health care programs in the United States is now a major focus in the era of health care reform. New programs need to be evaluated as alternatives are developed in the health care system. The BirthPlace program provides comprehensive perinatal services with certified nurse-midwives and obstetricians working together in an integrated collaborative practice serving a primarily low-income population. Low-risk women are delivered by nurse-midwives in a freestanding birth center (The BirthPlace), which is one component of a larger integrated health network...
July 1, 1998: Primary Care Update for Ob/Gyns
E Ward, R Hornung, J Morris, R Rinsky, D Wild, W Halperin, W Guthrie
This study evaluated the relationship between benzene exposure and low white blood cell (WBC) and red blood cell (RBC) counts. Hematologic screening data collected over a 35 year period at a rubber hydrochloride manufacturing plant were analyzed; an increased risk of leukemia had been demonstrated previously among workers at the plant [Infante et al. (1977).' Lancet 2:76-78; Rinsky et al. (1981): Am J Ind Med 2:217-45 (1987): NEJM 316:1044-1050/. Hematologic screening data were available for 657 of 1,037 (63...
March 1996: American Journal of Industrial Medicine
E D Johnson, M C Sievert, E J McKinin
It has been established that subject searches of medical full-text databases obtain higher recall than subject searches in a bibliographic database. In this study we attempted to determine if the same rule might apply when searching for a non-subject parameter such as study design. A simultaneous search of bibliographic and full-text records from the New England Journal of Medicine provided data on the number of items retrieved by each kind of search. Filtering strategies were created for 5 different study types: randomized controlled trials, other clinical trials and prospective studies, cohort studies, longitudinal and follow-up studies, and multicenter studies...
1995: Proceedings
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