keyword
https://read.qxmd.com/read/38311755/asymptomatic-spinal-lesions-in-patients-with-aqp4-igg-positive-nmosd-a-real-world-cohort-study
#21
JOURNAL ARTICLE
Shugang Cao, Yunfei Zhu, Xiaosan Wu, Jing Du, Si Xu, Ping Cui, Qi Li, Mingwu Xia, Qun Xue, Yanghua Tian
OBJECTIVE: This study aims to explore the frequency and influencing factors of asymptomatic spinal lesions (ASLs) and their impact on subsequent relapses in patients with AQP4-IgG-positive NMOSD (AQP4-NMOSD) in a real-world setting. METHODS: We retrospectively reviewed clinical information and spinal MRI data from AQP4-NMOSD patients who had at least one spinal cord MRI during their follow-ups. Kaplan-Meier curves and Cox proportional hazards models were employed to ascertain potential predictors of remission ASLs and to investigate factors associated with subsequent relapses...
February 4, 2024: Annals of Clinical and Translational Neurology
https://read.qxmd.com/read/38310001/intracerebral-hemodynamic-abnormalities-in-patients-with-parkinson-s-disease-comparison-between-multi-delay-arterial-spin-labelling-and-conventional-single-delay-arterial-spin-labelling
#22
JOURNAL ARTICLE
Xue Wang, Lijuan Wang, Yating Wu, Xiang Lv, Yao Xu, Weiqiang Dou, Hongying Zhang, Jingtao Wu, Song'an Shang
PURPOSE: The purpose of this study was to analyze the intracerebral abnormalities of hemodynamics in patients with Parkinson's disease (PD) through arterial spin labelling (ASL) technique with multi-delay ASL (MDASL) and conventional single-delay ASL (SDASL) protocols and to verify the potential clinical application of these features for the diagnosis of PD. MATERIALS AND METHODS: Perfusion data of the brain obtained using MDASL and SDASL in patients with PD were compared to those obtained in healthy control (HC) subjects...
February 2, 2024: Diagnostic and Interventional Imaging
https://read.qxmd.com/read/38305610/differential-diagnostic-value-of-3-0t-mr-3d-asl-technique-for-recurrence-and-pseudo-progression-of-high-grade-glioma
#23
JOURNAL ARTICLE
Y-S Chen, S-Y Zheng, L-L Huang, Y-G Xu, S-Q Chen, A-L Zhan
OBJECTIVE: This study aimed to explore the value of 3.0T magnetic resonance three-dimensional arterial spin labeling imaging (3D-ASL) technology in the differential diagnosis of recurrence and pseudo-progression of high-grade gliomas. PATIENTS AND METHODS: Fifty patients with high-grade glioma were selected as research objects. All 50 patients were examined by magnetic resonance imaging (MRI), and the lesions were found to be enlarged or abnormally enhanced. All the patients were examined using the 3...
January 2024: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/38299767/evaluation-of-kidney-injury-using-arterial-spin-labeling-and-blood-oxygen-level-dependent-mri-an-experimental-study-in-rats-with-carbon-tetrachloride-induced-liver-cirrhosis
#24
JOURNAL ARTICLE
Jiaming Qin, Shuangshuang Xie, Yongquan Yu, Jiaqi Yang, Yumeng Zhao, Caixin Qiu, Xiaotian Li, Cheng Zhang, Zhandong Hu, Dan Tong, Jinxia Zhu, Bernd Kuehn, Wen Shen
BACKGROUND: Serum creatinine (Scr) may be not suited to timely and accurately reflect kidney injury related to chronic liver disease. Currently, the ability of arterial spin labeling (ASL) and blood oxygen level-dependent (BOLD) sequences to evaluate renal blood flow (RBF) and blood oxygen in chronic liver disease remains to be verified. PURPOSE: To investigate the value of ASL and BOLD imaging in evaluating hemodynamics and oxygenation changes during kidney injury in an animal model of chronic liver disease...
February 1, 2024: Journal of Magnetic Resonance Imaging: JMRI
https://read.qxmd.com/read/38298860/extracting-functional-connectivity-brain-networks-at-the-resting-state-from-pulsed-arterial-spin-labeling-data
#25
JOURNAL ARTICLE
Natalie Wiseman, Armin Iraji, E Mark Haacke, Vince Calhoun, Zhifeng Kou
INTRODUCTION: Functional connectivity in the brain is often studied with blood oxygenation level dependent (BOLD) resting state functional magnetic resonance imaging (rsfMRI), but the BOLD signal is several steps removed from neuronal activity. Arterial spin labeling (ASL), particularly pulsed ASL (PASL), has also the capacity to measure the blood-flow changes in response to activity. In this paper, we investigated the feasibility of extracting major brain networks from PASL data, in contrast with rsfMRI analsyis...
September 2023: Meta Radiol
https://read.qxmd.com/read/38298648/nonconvulsive-status-epilepticus-in-patients-with-acute-subarachnoid-hemorrhage-is-associated-with-negative-arterial-spin-labeling-on-peri-ictal-magnetic-resonance-images
#26
JOURNAL ARTICLE
Yoshiteru Tada, Toshitaka Fujihara, Izumi Yamaguchi, Masaaki Korai, Shu Sogabe, Mai Azumi, Eiji Shikata, Koji Bando, Kohei Nakajima, Kenji Shimada, Nobuaki Yamamoto, Hiroki Yamazaki, Yuishin Izumi, Masafumi Harada, Yasuhisa Kanematsu, Yasushi Takagi
PURPOSE: Non-convulsive status epilepticus (NCSE) is characterized by repetitive or continuous seizures without convulsions. Arterial spin labeling (ASL) is useful for assessing hyperperfusion due to neurovascular unit coupling in patients with NCSE; subarachnoid hemorrhage (SAH) impairs the neurovascular unit. We hypothesized that the sensitivity of ASL in detecting NCSE is low in patients with SAH during the acute phase. METHODS: Based on ASL findings obtained within 48 h after the clinical suspicion of focal-onset NCSE, we divided 34 patients into ASL-negative (no hyperperfusion; n = 10) and ASL-positive (confirmed hyperperfusion; n = 24) groups...
January 30, 2024: Heliyon
https://read.qxmd.com/read/38296269/point-of-care-low-field-mri-in-acute-stroke-pocs-protocol-for-a-multicentric-prospective-open-label-study-evaluating-diagnostic-accuracy
#27
JOURNAL ARTICLE
Matteo Foschi, Angelo Galante, Raffaele Ornello, Stefano Necozione, Carmine Marini, Mario Muselli, Paola Olimpia Achard, Luciano Fratocchi, Sergio Lucio Vinci, Marco Cavallaro, Mauro Silvestrini, Gabriele Polonara, Simona Marcheselli, Laura Straffi, Marco Colasurdo, Luca Sorrentino, Enrico Franconi, Marcello Alecci, Massimo Caulo, Simona Sacco
INTRODUCTION: Fast and accurate diagnosis of acute stroke is crucial to timely initiate reperfusion therapies. Conventional high-field (HF) MRI yields the highest accuracy in discriminating early ischaemia from haemorrhages and mimics. Rapid access to HF-MRI is often limited by contraindications or unavailability. Low-field (LF) MRI (<0.5T) can detect several types of brain injury, including ischaemic and haemorrhagic stroke. Implementing LF-MRI in acute stroke care may offer several advantages, including extended applicability, increased safety, faster administration, reduced staffing and costs...
January 31, 2024: BMJ Open
https://read.qxmd.com/read/38280508/association-between-asl-mri-derived-cerebral-blood-flow-and-outcomes-after-pediatric-cardiac-arrest
#28
JOURNAL ARTICLE
Matthew P Kirschen, Minhui Ouyang, Bhavesh Patel, Jeffrey I Berman, Ryan Burnett, Robert A Berg, Ramon Diaz-Arrastia, Alexis Topjian, Hao Huang, Arastoo Vossough
AIM: Cerebral blood flow (CBF) is dysregulated after cardiac arrest. It is unknown if post-arrest CBF is associated with outcome. We aimed to determine the association of CBF derived from arterial spin labelling (ASL) MRI with outcome after pediatric cardiac arrest. METHODS: Retrospective observational study of patients ≤18 years who had a clinically obtained brain MRI within 7 days of cardiac arrest between June 2005 and December 2019. Primary outcome was unfavorable neurologic status: change in Pediatric Cerebral Performance Category (PCPC) ≥1 from pre-arrest that resulted in hospital discharge PCPC 3-6...
January 25, 2024: Resuscitation
https://read.qxmd.com/read/38270821/comparison-of-18-f-fdg-pet-and-arterial-spin-labeling-mri-in-evaluating-alzheimer-s-disease-and-amnestic-mild-cognitive-impairment-using-integrated-pet-mr
#29
JOURNAL ARTICLE
Sheng Bi, Shaozhen Yan, Zhigeng Chen, Bixiao Cui, Yi Shan, Hongwei Yang, Zhigang Qi, Zhilian Zhao, Ying Han, Jie Lu
BACKGROUND: Developing biomarkers for early stage AD patients is crucial. Glucose metabolism measured by 18 F-FDG PET is the most common biomarker for evaluating cellular energy metabolism to diagnose AD. Arterial spin labeling (ASL) MRI can potentially provide comparable diagnostic information to 18 F-FDG PET in patients with neurodegenerative disorders. However, the conclusions about the diagnostic performance of AD are still controversial between 18 F-FDG PET and ASL. This study aims to compare quantitative cerebral blood flow (CBF) and glucose metabolism measured by 18 F-FDG PET diagnostic values in patients with Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI) using integrated PET/MR...
January 25, 2024: EJNMMI Research
https://read.qxmd.com/read/38235314/a-novel-5-stage-visual-rating-scale-for-global-arterial-spin-labeling-perfusion-assessment-in-the-brain-simplifying-evaluation-for-clinical-implementation
#30
JOURNAL ARTICLE
Emilian Kalchev, Radoslav Georgiev, Darina Ivanova
OBJECTIVES: The aim of this study was to develop and validate a visual rating scale for evaluating global arterial spin labeling (ASL) perfusion changes in the brain, with potential applications in a variety of conditions that impact general brain blood supply and perfusion. METHODS: We employed a five-stage scale (0 being normal and 4 indicating the most severe perfusion decline) to assess 156 patients using a 3D pulsed ASL technique. Three radiologists independently reviewed the images, and inter-rater reliability of the visual rating scale was evaluated...
2024: Cerebral circulation—cognition and behavior
https://read.qxmd.com/read/38206090/comparison-of-myocardial-blood-flow-quantification-models-for-double-ecg-gating-arterial-spin-labeling-mri-reproducibility-assessment
#31
JOURNAL ARTICLE
Verónica Aramendía-Vidaurreta, Sergio M Solís-Barquero, Marta Vidorreta, Ana Ezponda, Rebeca Echeverria-Chasco, Gorka Bastarrika, María A Fernández-Seara
BACKGROUND: Arterial spin labeling (ASL) allows non-invasive quantification of myocardial blood flow (MBF). Double-ECG gating (DG) ASL is more robust to heart rate variability than single-ECG gating (SG), but its reproducibility requires further investigation. Moreover, the existence of multiple quantification models hinders its application. Frequency-offset-corrected-inversion (FOCI) pulses provide sharper edge profiles than hyperbolic-secant (HS), which could benefit myocardial ASL...
January 11, 2024: Journal of Magnetic Resonance Imaging: JMRI
https://read.qxmd.com/read/38204176/longitudinal-brain-perfusion-and-symptom-presentation-following-pediatric-concussion-a-pediatric-concussion-assessment-of-rest-and-exertion-mri-pedcare-mri-substudy
#32
JOURNAL ARTICLE
Veronik Sicard, Zhuo Fang, Rachel Kardish, Katherine Healey, Andra M Smith, Sarah Reid, Greg O Cron, Gerd Melkus, Nishard Abdeen, Keith Owen Yeates, Gary Goldfield, Nick Reed, Roger Zemek, Andrée-Anne Ledoux
Emerging evidence suggests that advanced neuroimaging modalities such as arterial spin labelling (ASL) might have prognostic utility for pediatric concussion. This study aimed to: 1) examine group differences in global and regional brain perfusion in youth with concussion or orthopedic injury (OI) at 72 h and 4 weeks post-injury; 2) examine patterns of abnormal brain perfusion within both groups and their recovery; 3) investigate the association between perfusion and symptom burden within concussed and OI youths at both time-points; and 4) explore perfusion between symptomatic and asymptomatic concussed and OI youths...
January 30, 2024: Journal of Neurotrauma
https://read.qxmd.com/read/38203813/effects-of-low-level-blast-on-neurovascular-health-and-cerebral-blood-flow-current-findings-and-future-opportunities-in-neuroimaging
#33
REVIEW
Madison O Kilgore, W Brad Hubbard
Low-level blast (LLB) exposure can lead to alterations in neurological health, cerebral vasculature, and cerebral blood flow (CBF). The development of cognitive issues and behavioral abnormalities after LLB, or subconcussive blast exposure, is insidious due to the lack of acute symptoms. One major hallmark of LLB exposure is the initiation of neurovascular damage followed by the development of neurovascular dysfunction. Preclinical studies of LLB exposure demonstrate impairment to cerebral vasculature and the blood-brain barrier (BBB) at both early and long-term stages following LLB...
January 4, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38201327/imaging-techniques-and-clinical-application-of-the-marrow-blood-barrier-in-hematological-malignancies
#34
REVIEW
Jianling Zhang, Qianqian Huang, Wenjin Bian, Jun Wang, Haonan Guan, Jinliang Niu
The pathways through which mature blood cells in the bone marrow (BM) enter the blood stream and exit the BM, hematopoietic stem cells in the peripheral blood return to the BM, and other substances exit the BM are referred to as the marrow-blood barrier (MBB). This barrier plays an important role in the restrictive sequestration of blood cells, the release of mature blood cells, and the entry and exit of particulate matter. In some blood diseases and tumors, the presence of immature cells in the blood suggests that the MBB is damaged, mainly manifesting as increased permeability, especially in angiogenesis...
December 21, 2023: Diagnostics
https://read.qxmd.com/read/38185882/multimodal-imaging-measures-in-the-prediction-of-clinical-response-to-deep-brain-stimulation-for-refractory-depression-a-machine-learning-approach
#35
JOURNAL ARTICLE
Rajamannar Ramasubbu, Elliot C Brown, Pauline Mouches, Jasmine A Moore, Darren L Clark, Christine P Molnar, Zelma H T Kiss, Nils D Forkert
OBJECTIVES: This study compared machine learning models using unimodal imaging measures and combined multi-modal imaging measures for deep brain stimulation (DBS) outcome prediction in treatment resistant depression (TRD). METHODS: Regional brain glucose metabolism (CMRGlu), cerebral blood flow (CBF), and grey matter volume (GMV) were measured at baseline using 18F-fluorodeoxy glucose (18F- FDG) positron emission tomography (PET), arterial spin labelling (ASL) magnetic resonance imaging (MRI), and T1-weighted MRI, respectively, in 19 patients with TRD receiving subcallosal cingulate (SCC)-DBS...
January 7, 2024: World Journal of Biological Psychiatry
https://read.qxmd.com/read/38185186/model-based-super-resolution-reconstruction-for-pseudo-continuous-arterial-spin-labeling
#36
JOURNAL ARTICLE
Q Beirinckx, P Bladt, M C E van der Plas, M J P van Osch, B Jeurissen, A J den Dekker, J Sijbers
Arterial spin labeling (ASL) is a promising, non-invasive perfusion magnetic resonance imaging technique for quantifying cerebral blood flow (CBF). Unfortunately, ASL suffers from an inherently low signal-to-noise ratio (SNR) and spatial resolution, undermining its potential. Increasing spatial resolution without significantly sacrificing SNR or scan time represents a critical challenge towards routine clinical use. In this work, we propose a model-based super-resolution reconstruction (SRR) method with joint motion estimation that breaks the traditional SNR/resolution/scan-time trade-off...
January 5, 2024: NeuroImage
https://read.qxmd.com/read/38179863/mri-assessment-of-cerebral-white-matter-microvascular-hemodynamics-across-the-adult-lifespan
#37
JOURNAL ARTICLE
Nikou L Damestani, John Jacoby, Christa B Michel, Barnaly Rashid, David H Salat, Meher R Juttukonda
BACKGROUND: Changes in cerebral hemodynamics with aging are important for understanding age-related variation in neuronal health. While many prior studies have focused on gray matter, less is known regarding white matter due in part to measurement challenges related to the lower vascular density in white matter. PURPOSE: To investigate the impact of age and sex on white matter hemodynamics in a Human Connectome Project in Aging (HCP-A) cohort using tract-based spatial statistics (TBSS)...
January 5, 2024: Journal of Magnetic Resonance Imaging: JMRI
https://read.qxmd.com/read/38176978/the-value-of-functional-magnetic-resonance-imaging-in-evaluating-renal-allograft-function
#38
JOURNAL ARTICLE
Jin Peng, Juan Gao, Yajun Hong, Zhengcan Wu, Guozhong Chen, Guangming Lu
BACKGROUND: To explore the value of arterial spin labeled (ASL) and blood oxygen level dependent (BOLD) imaging in evaluating allogeneic kidney function after renal transplantation. METHODS: One hundred and thirty-five renal transplant patients were included. Demographic and imaging data were collected. Transplanted renal function, pathology, ASL and BOLD parameters were obtained. The patients were divided into normal, mild and severe injury group. The correlation between BOLD/ASL parameters and clinical data were evaluated...
January 3, 2024: Asian Journal of Surgery
https://read.qxmd.com/read/38173296/optimizing-background-suppression-for-dual-module-velocity-selective-arterial-spin-labeling-without-using-additional-background-suppression-pulses
#39
JOURNAL ARTICLE
Jia Guo
PURPOSE: Background suppression (BS) is recommended in arterial spin labeling (ASL) for improved SNR but is difficult to optimize in existing velocity-selective ASL (VSASL) methods. Dual-module VSASL (dm-VSASL) enables delay-insensitive, robust, and SNR-efficient perfusion imaging, while allowing efficient BS, but its optimization has yet to be thoroughly investigated. METHODS: The inversion effects of the velocity-selective labeling pulses, such as velocity-selective inversion (VSI), can be used for BS, and were modeled for optimizing BS in dm-VSASL...
January 3, 2024: Magnetic Resonance in Medicine
https://read.qxmd.com/read/38137100/effect-of-meditation-on-brain-activity-during-an-attention-task-a-comparison-study-of-asl-and-bold-task-fmri
#40
JOURNAL ARTICLE
Yakun Zhang, Shichun Chen, Zongpai Zhang, Wenna Duan, Li Zhao, George Weinschenk, Wen-Ming Luh, Adam K Anderson, Weiying Dai
Focused attention meditation (FAM) training has been shown to improve attention, but the neural basis of FAM on attention has not been thoroughly understood. Here, we aim to investigate the neural effect of a 2-month FAM training on novice meditators in a visual oddball task (a frequently adopted task to evaluate attention), evaluated with both ASL and BOLD fMRI. Using ASL, activation was increased in the middle cingulate (part of the salience network, SN) and temporoparietal (part of the frontoparietal network, FPN) regions; the FAM practice time was negatively associated with the longitudinal changes in activation in the medial prefrontal (part of the default mode network, DMN) and middle frontal (part of the FPN) regions...
November 29, 2023: Brain Sciences
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