keyword
https://read.qxmd.com/read/38496517/high-resolution-multi-delay-arterial-spin-labeling-with-transformer-based-denoising-for-pediatric-perfusion-mri
#1
Qinyang Shou, Chenyang Zhao, Xingfeng Shao, Megan M Herting, Danny Jj Wang
Multi-delay arterial spin labeling (MDASL) can quantitatively measure cerebral blood flow (CBF) and arterial transit time (ATT), which is particularly suitable for pediatric perfusion imaging. Here we present a high resolution (iso-2mm) MDASL protocol and performed test-retest scans on 21 typically developing children aged 8 to 17 years. We further proposed a Transformer-based deep learning (DL) model with k-space weighted image average (KWIA) denoised images as reference for training the model. The performance of the model was evaluated by the SNR of perfusion images, as well as the SNR, bias and repeatability of the fitted CBF and ATT maps...
March 6, 2024: medRxiv
https://read.qxmd.com/read/38485759/identifying-delay-in-glymphatic-clearance-of-labeled-protons-post-acute-head-trauma-utilizing-3d-asl-mri-arterial-spin-labeling-a-pilot-study
#2
JOURNAL ARTICLE
Charles R Joseph, Jubin Kang Lim, Bryce N Grohol, Marija Zivcevska, Joshua Lencke, Ethan Dean Rich, Connor James Arrasmith, Ian Shepherd Dorman, Bradley Waman Clark, Kim Love, Ben Ferry, Mark E Rolfs
This study correlated mild traumatic brain injury (mTBI) cognitive changes with ASL-MRI glymphatic clearance rates (GCRs) and recovery with GCR improvement. mTBI disrupts the blood brain barrier (BBB), reducing capillary mean transit time and GCRs. mTBI is clinically diagnosed utilizing history/examination findings with no physiologic biomarkers. 3D TGSE (turbo-gradient spin-echo) pulsed arterial spin-labeling 3T MRI with 7 long inversion times (TIs) assessed the signal clearance of labeled protons 2800-4000 ms postlabeling in bifrontal, bitemporal, and biparietal regions within 7 days of mTBI and once clinically cleared to resume activities...
March 14, 2024: Scientific Reports
https://read.qxmd.com/read/38483125/perfusion-imaging-by-arterial-spin-labeling-in-migraine-a-literature-review
#3
REVIEW
Severin Schramm, Corinna Börner, Miriam Reichert, Gabriel Hoffmann, Stephan Kaczmarz, Michael Griessmair, Kirsten Jung, Maria T Berndt, Claus Zimmer, Thomas Baum, Florian Heinen, Michaela V Bonfert, Nico Sollmann
Arterial spin labeling (ASL) is a non-invasive magnetic resonance imaging (MRI) method for the assessment of cerebral blood flow (CBF). This review summarizes recent ASL-based investigations in adult and pediatric patients with migraine with aura, migraine without aura, and chronic migraine. A systematic search according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines was conducted within PubMed and reference sections of articles identified from April 2014 to November 2022...
March 14, 2024: Journal of Cerebral Blood Flow and Metabolism
https://read.qxmd.com/read/38472033/brain-mri-in-status-epilepticus-relevance-of-findings
#4
REVIEW
T Bonduelle, M Ollivier, A Gradel, J Aupy
Status epilepticus (SE) represents one of the most common neurological emergencies, associated with high mortality and an important risk of functional sequelae in survivors. Magnetic resonance imaging (MRI) offers the possibility of early and noninvasive observation of seizure-induced parenchymal disturbances secondary to the epileptic process. In the present review, we propose a descriptive and comprehensive understanding of current knowledge concerning seizure-induced MRI abnormalities in SE, also called peri-ictal MRI abnormalities (PMAs)...
March 11, 2024: Revue Neurologique
https://read.qxmd.com/read/38464343/multi%C3%A2-parameter-quantitative-magnetic-resonance-imaging-in-the-early-assessment-of-radiation%C3%A2-induced-parotid-damage-in-patients-with-nasopharyngeal-carcinoma-following-intensity%C3%A2-modulated-radiotherapy
#5
JOURNAL ARTICLE
Xianhai Zhang, Zhifeng Xu, Yabin Jin, Linwen Huang, Wenxiu Wu, Mingyong Gao
The present study aimed to investigate the value of intravoxel incoherent motion imaging (IVIM) and three-dimensional pulsed continuous arterial spin labeling (ASL) in assessing dynamic changes of the parotid gland in patients with nasopharyngeal carcinoma (NPC) following radiotherapy (RT). A total of 18 patients with NPC who underwent intensity-modulated RT were enrolled in the present study. All patients underwent conventional magnetic resonance imaging, plus IVIM and ASL imaging of the bilateral parotid glands within 2 weeks prior to RT, and 1 week (1W) and 3 months (3M) following RT...
April 2024: Oncology Letters
https://read.qxmd.com/read/38458785/developing-blood-brain-barrier-arterial-spin-labelling-as-a-non-invasive-early-biomarker-of-alzheimer-s-disease-debbie-ad-a-prospective-observational-multicohort-study-protocol
#6
JOURNAL ARTICLE
Beatriz Padrela, Amnah Mahroo, Mervin Tee, Markus H Sneve, Paulien Moyaert, Oliver Geier, Joost P A Kuijer, Soetkin Beun, Wibeke Nordhøy, Yufei David Zhu, Mareike A Buck, Daniel C Hoinkiss, Simon Konstandin, Jörn Huber, Julia Wiersinga, Roos Rikken, Diederick de Leeuw, Håkon Grydeland, Lynette Tippett, Erin E Cawston, Esin Ozturk-Isik, Jennifer Linn, Moritz Brandt, Betty M Tijms, Elsmarieke M van de Giessen, Majon Muller, Anders Fjell, Kristine Walhovd, Atle Bjørnerud, Lene Pålhaugen, Per Selnes, Patricia Clement, Eric Achten, Udunna Anazodo, Frederik Barkhof, Saima Hilal, Tormod Fladby, Klaus Eickel, Catherine Morgan, David L Thomas, Jan Petr, Matthias Günther, Henk J M M Mutsaerts
INTRODUCTION: Loss of blood-brain barrier (BBB) integrity is hypothesised to be one of the earliest microvascular signs of Alzheimer's disease (AD). Existing BBB integrity imaging methods involve contrast agents or ionising radiation, and pose limitations in terms of cost and logistics. Arterial spin labelling (ASL) perfusion MRI has been recently adapted to map the BBB permeability non-invasively. The DEveloping BBB-ASL as a non-Invasive Early biomarker (DEBBIE) consortium aims to develop this modified ASL-MRI technique for patient-specific and robust BBB permeability assessments...
March 8, 2024: BMJ Open
https://read.qxmd.com/read/38446857/insights-into-hippocampal-perfusion-using-high-resolution-multi-modal-7t-mri
#7
JOURNAL ARTICLE
Roy A M Haast, Sriranga Kashyap, Dimo Ivanov, Mohamed D Yousif, Jordan DeKraker, Benedikt A Poser, Ali R Khan
We present a comprehensive study on the non-invasive measurement of hippocampal perfusion. Using high-resolution 7 tesla arterial spin labeling (ASL) data, we generated robust perfusion maps and observed significant variations in perfusion among hippocampal subfields, with CA1 exhibiting the lowest perfusion levels. Notably, these perfusion differences were robust and already detectable with 50 perfusion-weighted images per subject, acquired in 5 min. To understand the underlying factors, we examined the influence of image quality metrics, various tissue microstructure and morphometric properties, macrovasculature, and cytoarchitecture...
March 12, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38432944/differences-between-acute-embolic-and-atherosclerotic-middle-cerebral-artery-occlusion-in-multiphase-arterial-spin-labeling-imaging
#8
JOURNAL ARTICLE
Yasuhiro Ito, Taku Sugiyama, Shunsuke Terasaka, Hitoshi Matsuzawa, Kuniaki Harada, Naoki Nakayama, Masaki Ito, Katsuhiko Maruichi, Miki Fujimura
Arterial spin-labeling magnetic resonance imaging (ASL-MRI) is widely used for evaluating collateral development in patients with acute ischemic stroke (AIS). This study aimed to characterize the findings of multiphase ASL-MRI between embolic and atherosclerotic large vessel occlusion (LVO) to aid in the differential diagnosis. Among 982 patients with AIS, 44 who were diagnosed with acute, symptomatic, and unilateral occlusion of the horizontal segment of the middle cerebral artery (MCA) were selected and categorized into embolic stroke (ES) and atherosclerosis (AT) groups...
March 4, 2024: Neurologia Medico-chirurgica
https://read.qxmd.com/read/38430800/dysregulated-cerebral-blood-flow-rather-than-gray-matter-volume-exhibits-stronger-correlations-with-blood-inflammatory-and-lipid-markers-in-depression
#9
JOURNAL ARTICLE
Lijun Kang, Wei Wang, Zhaowen Nie, Qian Gong, Lihua Yao, Dan Xiang, Nan Zhang, Ning Tu, Hongyan Feng, Xiaofen Zong, Hanping Bai, Gaohua Wang, Fei Wang, Lihong Bu, Zhongchun Liu
Arterial spin labeling (ASL) can be used to detect differences in perfusion for multiple brain regions thought to be important in major depressive disorder (MDD). However, the potential of cerebral blood flow (CBF) to predict MDD and its correlations between the blood lipid levels and immune markers, which are closely related to MDD and brain function change, remain unclear. The 451 individuals - 298 with MDD and 133 healthy controls who underwent MRI at a single time point with arterial spin labelling and a high resolution T1-weighted structural scan...
February 28, 2024: NeuroImage: Clinical
https://read.qxmd.com/read/38429974/cerebrovascular-reactivity-to-hypercapnia-in-patients-with-migraine-a-dual-echo-arterial-spin-labeling-mri-study
#10
JOURNAL ARTICLE
E S Hoogeveen, N Pelzer, E Ghariq, M J P van Osch, A Dahan, G M Terwindt, M C Kruit
OBJECTIVE: This study aimed to compare cerebrovascular reactivity between patients with migraine and controls using state-of-the-art magnetic resonance imaging (MRI) techniques. BACKGROUND: Migraine is associated with an increased risk of cerebrovascular disease, but the underlying mechanisms are still not fully understood. Impaired cerebrovascular reactivity has been proposed as a link. Previous studies have evaluated cerebrovascular reactivity with different methodologies and results are conflicting...
March 2, 2024: Headache
https://read.qxmd.com/read/38414703/retrograde-flow-into-the-internal-jugular-vein-in-a-hemodialysis-patient-mimicking-dural-arteriovenous-fistula-a-case-report
#11
Eri Shiozaki, Yoichi Morofuji, Tsuyoshi Izumo, Takayuki Matsuo
Arterial spin labeling (ASL) and three-dimensional (3D) time-of-flight (TOF) magnetic resonance angiography (MRA) are sensitive tools to detect dural arteriovenous fistula (DAVF), but hyperintensity in these images is also caused by jugular venous reflux. We present a case of a patient with renal failure on hemodialysis with retrograde flow into the internal jugular vein (IJV) mimicking DAVF. A 74-year-old man with a radial arteriovenous fistula for hemodialysis experienced transient dizziness. The TOF MRA and ASL revealed high signal intensity, suggesting the presence of a DAVF in the left transverse and sigmoid sinuses and the IJV...
January 2024: Curēus
https://read.qxmd.com/read/38403798/improving-advanced-intraoperative-mri-methods-during-pediatric-neurosurgery
#12
JOURNAL ARTICLE
Pien E J Jellema, Lilli M Mannsdörfer, Fredy Visser, Alberto De Luca, Cynthia L E Smit, Eelco W Hoving, Kirsten M van Baarsen, Thomas Lindner, Henk-Jan M M Mutsaerts, Jan Willem Dankbaar, Maarten H Lequin, Jannie P Wijnen
Advanced intraoperative MR images (ioMRI) acquired during the resection of pediatric brain tumors could offer additional physiological information to preserve healthy tissue. With this work, we aimed to develop a protocol for ioMRI with increased sensitivity for arterial spin labeling (ASL) and diffusion MRI (dMRI), optimized for patient positioning regularly used in the pediatric neurosurgery setting. For ethical reasons, ASL images were acquired in healthy adult subjects that were imaged in the prone and supine position...
February 25, 2024: NMR in Biomedicine
https://read.qxmd.com/read/38400805/automated-quality-evaluation-index-for-arterial-spin-labeling-derived-cerebral-blood-flow-maps
#13
JOURNAL ARTICLE
Sudipto Dolui, Ze Wang, Ronald L Wolf, Ali Nabavizadeh, Long Xie, Duygu Tosun, Ilya M Nasrallah, David A Wolk, John A Detre
BACKGROUND: Arterial spin labeling (ASL) derived cerebral blood flow (CBF) maps are prone to artifacts and noise that can degrade image quality. PURPOSE: To develop an automated and objective quality evaluation index (QEI) for ASL CBF maps. STUDY TYPE: Retrospective. POPULATION: Data from N = 221 adults, including patients with Alzheimer's disease (AD), Parkinson's disease, and traumatic brain injury. FIELD STRENGTH/SEQUENCE: Pulsed or pseudocontinuous ASL acquired at 3 T using non-background suppressed 2D gradient-echo echoplanar imaging or background suppressed 3D spiral spin-echo readouts...
February 24, 2024: Journal of Magnetic Resonance Imaging: JMRI
https://read.qxmd.com/read/38385182/assessing-the-pulmonary-vascular-responsiveness-to-oxygen-with-proton-mri
#14
JOURNAL ARTICLE
Abhilash S Kizhakke Puliyakote, Vincent Tedjasaputra, Gregory M Petersen, Rui Carlos Sá, Susan R Hopkins
Ventilation-perfusion matching occurs passively and is also actively regulated through hypoxic pulmonary vasoconstriction (HPV). The extent of HPV activity in humans, particularly normal subjects is uncertain. Current evaluation of HPV assesses changes in ventilation-perfusion relationships/pulmonary vascular resistance with hypoxia and are invasive, or unsuitable for patients because of safety concerns. We used a non-invasive imaging-based approach to quantify the pulmonary vascular response to oxygen as a metric of HPV by measuring perfusion changes between breathing 21% and 30%O2 using arterial spin labeling (ASL) MRI...
February 22, 2024: Journal of Applied Physiology
https://read.qxmd.com/read/38364110/the-influence-of-voxelotor-on-cerebral-blood-flow-and-oxygen-extraction-in-pediatric-sickle-cell-disease
#15
JOURNAL ARTICLE
Rowan O Brothers, Katherine B Turrentine, Mariam Akbar, Sydney Triplett, Hongting Zhao, Tara M Urner, Adam Ezra Goldman-Yassen, Richard A Jones, Jack Knight-Scott, Sarah S Milla, Shasha Bai, Amy Y Tang, Clark Brown, Erin M Buckley
Voxelotor is an inhibitor of sickle hemoglobin polymerization that is used to treat sickle cell disease. While voxelotor has been shown to improve anemia, the clinical benefit on the brain remains to be determined. This study quantified the cerebral hemodynamic effects of voxelotor in children with sickle cell anemia (SCA) using non-invasive diffuse optical spectroscopies. Specifically, frequency-domain near-infrared spectroscopy (FDNIRS) combined with diffuse correlation spectroscopy (DCS) were used to noninvasively assess regional oxygen extraction fraction (OEF), cerebral blood volume (CBV), and an index of cerebral blood flow (CBFi)...
February 16, 2024: Blood
https://read.qxmd.com/read/38355219/cervical-spinal-cord-angiography-and-vessel-selective-perfusion-imaging-in-the-rat
#16
JOURNAL ARTICLE
Seongtaek Lee, Brian D Schmit, Shekar N Kurpad, Matthew D Budde
Arterial spin labeling (ASL) has been widely used to evaluate arterial blood and perfusion dynamics, particularly in the brain, but its application to the spinal cord has been limited. The purpose of this study was to optimize vessel-selective pseudocontinuous arterial spin labeling (pCASL) for angiographic and perfusion imaging of the rat cervical spinal cord. A pCASL preparation module was combined with a train of gradient echoes for dynamic angiography. The effects of the echo train flip angle, label duration, and a Cartesian or radial readout were compared to examine their effects on visualizing the segmental arteries and anterior spinal artery (ASA) that supply the spinal cord...
February 14, 2024: NMR in Biomedicine
https://read.qxmd.com/read/38347458/in-vivo-pet-of-synaptic-density-as-potential-diagnostic-marker-for-cognitive-disorders-prospective-comparison-with-current-imaging-markers-for-neuronal-dysfunction-and-relation-to-symptomatology-study-protocol
#17
JOURNAL ARTICLE
Greet Vanderlinden, Charles Carron, Rik Vandenberghe, Mathieu Vandenbulcke, Koen Van Laere
BACKGROUND: 18 F-FDG brain PET is clinically used for differential diagnosis in cognitive dysfunction of unclear etiology and for exclusion of a neurodegenerative cause in patients with cognitive impairment in late-life psychiatric disorders. 18 F-FDG PET measures regional glucose metabolism, which represents a combination of neuronal/synaptic activity but also astrocytic activity and neuroinflammation. Recently, imaging of synaptic vesicle protein 2 A (SV2A) has become available and was shown to be a proxy of synaptic density...
February 12, 2024: BMC Medical Imaging
https://read.qxmd.com/read/38336633/arterial-transit-artifact-as-a-short-term-prognostic-indicator-in-acute-ischemic-stroke
#18
JOURNAL ARTICLE
Min Shan, Kaili Liu, Yi Ma, Qingxiu Zhang, Wenwei Yun, Min Zhang
BACKGROUND: Arterial transit artifact (ATA) observed on arterial spin labeling (ASL) was recently suggested to be associated with improved functional outcomes following acute ischemic stroke (AIS). AIS is a heterogeneous disease with diverse pathogenic mechanisms depending on the stroke subtype. This study aimed to investigate the association between ATA and 3-month functional outcomes in AIS patients according to etiology subtypes. METHODS: Consecutive patients with AIS were included...
February 9, 2024: BMC Neurology
https://read.qxmd.com/read/38327487/regional-cerebral-blood-flow-and-brain-atrophy-in-mild-cognitive-impairment-and-alzheimer-s-disease
#19
JOURNAL ARTICLE
Fardin Nabizadeh, Mohammad Balabandian, Mohammad Reza Rostami, Soraya Mehrabi, Mohsen Sedighi
OBJECTIVES: A decline in the regional cerebral blood flow (CBF) is proposed to be one of the initial changes in the Alzheimer's disease process. To date, there are limited data on the correlation between CBF decline and gray matter atrophy in mild cognitive impairment (MCI) and AD patients. to investigate the association between CBF with the gray matter structural parameters such as cortical volume, surface area, and thickness in AD, MCI, and healthy controls (HC). METHODS: Data from three groups of participants including 39 HC, 82 MCI, and 28 AD subjects were obtained from the Alzheimer's disease Neuroimaging Initiative (ADNI)...
April 2023: Neurol Lett
https://read.qxmd.com/read/38322728/dcs-blood-flow-index-underestimates-skeletal-muscle-perfusion-in-vivo-rationale-and-early-evidence-for-the-nirs-dcs-perfusion-index
#20
JOURNAL ARTICLE
Miles F Bartlett, Andrew P Oneglia, Mark D Ricard, Ashfaq Siddiqui, Erin K Englund, Erin M Buckley, Dennis M Hueber, Michael D Nelson
SIGNIFICANCE: Diffuse correlation spectroscopy (DCS) permits non-invasive assessment of skeletal muscle blood flow but may misestimate changes in muscle perfusion. AIM: We aimed to highlight recent evidence that DCS blood flow index (BFI) misestimates changes in muscle blood flow during physiological perturbation and to introduce a novel approach that adjusts BFI for estimated changes in vasodilation. APPROACH: We measured changes in muscle BFI during quadriceps and forearm exercises using DCS, the latter of which were adjusted for estimated changes in microvascular flow area and then compared to Doppler ultrasound in the brachial artery...
February 2024: Journal of Biomedical Optics
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