keyword
MENU ▼
Read by QxMD icon Read
search

dimer

keyword
https://www.readbyqxmd.com/read/29223047/identification-and-analysis-of-a-mercapturic-acid-conjugate-of-indole-3-methyl-isothiocyanate-in-the-urine-of-humans-who-consumed-cruciferous-vegetables
#1
Pramod Upadhyaya, Adam T Zarth, Naomi Fujioka, Vincent A Fritz, Stephen S Hecht
Glucobrassicin, a quantitatively significant constituent of Brassica vegetables, gives rise to indole-3-carbinol (I3C) and its dimer di-indolylmethane (DIM) when the vegetables are chewed. I3C and DIM have been extensively studied with respect to their anti-carcinogenic properties. However, the presumed intermediate isothiocyanate in their formation, indole-3-methyl isothiocyanate (IMITC), has to our knowledge never been observed, despite the fact that isothiocyanates derived from cruciferous vegetables are known to have anti-carcinogenic properties...
December 2, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29222746/cadmium-favors-f-actin-depolymerization-in-rat-renal-mesangial-cells-by-site-specific-disulfide-based-dimerization-of-the-cap1-protein
#2
Ying Liu, Weiqun Xiao, Manasi Shinde, Jeffrey Field, Douglas M Templeton
Cadmium is a toxic metal that produces oxidative stress and has been shown to disrupt the actin cytoskeleton in rat renal mesangial cells (RMC). In a survey of proteins that might undergo Cd2+-dependent disulfide crosslinking, we identified the adenylyl cyclase-associated protein, CAP1, as undergoing a dimerization in response to Cd2+ (5-40 µM) that was sensitive to disulfide reducing agents, was reproduced by the disulfide crosslinking agent diamide, and was shown by site-directed mutagenesis to involve the Cys29 residue of the protein...
December 8, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/29222465/the-dynamic-dimer-structure-of-the-chaperone-trigger-factor
#3
Leonor Morgado, Björn M Burmann, Timothy Sharpe, Adam Mazur, Sebastian Hiller
The chaperone Trigger Factor (TF) from Escherichia coli forms a dimer at cellular concentrations. While the monomer structure of TF is well known, the spatial arrangement of this dimeric chaperone storage form has remained unclear. Here, we determine its structure by a combination of high-resolution NMR spectroscopy and biophysical methods. TF forms a symmetric head-to-tail dimer, where the ribosome binding domain is in contact with the substrate binding domain, while the peptidyl-prolyl isomerase domain contributes only slightly to the dimer affinity...
December 8, 2017: Nature Communications
https://www.readbyqxmd.com/read/29222334/cellular-flip-long-isoform-cflipl-ikk%C3%AE-interactions-inhibit-irf7-activation-representing-a-new-cellular-strategy-to-inhibit-ifn%C3%AE-expression
#4
Lauren T Gates-Tanzer, Joanna L Shisler
IFNα is important for anti-viral and anticancer defenses. However, over-production is associated with autoimmune disorders. Thus, the cell must precisely up- and down-regulate IFNα to achieve immune system homeostasis. The cellular FLICE-like inhibitory protein (cFLIP) is reported to inhibit IFNα production. However, the mechanism for this antagonism remained unknown. The goal here was to identify this mechanism. Here, we examined the signal transduction events that occur during TLR9- induced IRF7 activation...
December 8, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29222099/isolation-of-the-pinoresinol-mineralizing-pseudomonas-sp-sg-ms2-and-elucidation-of-its-catabolic-pathway
#5
Madhura Shettigar, Sahil Balotra, David Cahill, Andrew C Warden, Michael J Lacey, Hans-Peter E Kohler, Daniel Rentsch, John G Oakeshott, Gunjan Pandey
Pinoresinol is a dimer of two β-β' linked coniferyl alcohol molecules. It is both a plant defence molecule synthesized from the shikimic acid pathway and a representative of several β-β linked dimers produced during the microbial degradation of lignin in dead plant material. Until now little has been known about the bacterial catabolism of such dimers. Here we report the isolation of an efficient (+)-pinoresinol mineralizing Pseudomonas sp. strain SG-MS2 and its catabolic pathway. Degradation of pinoresinol in this strain is inducible and proceeds via a novel oxidative route which is in contrast to the previously reported reductive transformation by other bacteria...
December 8, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29221988/modulations-of-keap1-nrf2-signaling-axis-by-tiia-ameliorated-the-oxidative-stress-induced-myocardial-apoptosis
#6
Shi-Hai Yan, Ning-Wei Zhao, Zhi-Rong Geng, Jia-Yin Shen, Fu-Ming Liu, Dong Yan, Jie Zhou, Chao Nie, Cheng-Cai Huang, Zhu-Yuan Fang
Mounting evidence has strongly implicated oxidative stress in the development of cardiac dysfunction, and myocardial apoptosis contributes to the pathogenesis of heart failure. Quantitative cardiac proteomics data revealed that pressure load by TAC resulted in a significant decline in mitochondrial metabolic activity, where TIIA (Tanshinone IIA sulfonate) treatment reversed it in vivo, which might be mediated by Nrf2. In NRVMs, TIIA treatment ameliorated H2O2-induced caspase-3/9 activations through the suppression of p38 and mTOR signaling pathways, where caspase-mediated cleavage of YY1 and PARP resulted in the defects in mitochondrial biogenesis and DNA repair, and this event finally led to cardiomyocyte apoptosis...
December 5, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29221971/preventive-treatment-with-lomerizine-increases-cerebral-blood-flows-during-the-interictal-phase-of-migraine
#7
Ken Ikeda, Joe Aoyagi, Sayori Hanashiro, Masahiro Sawada, Maya Kyuzen, Harumi Morioka, Junya Ebina, Junpei Nagasawa, Masaru Yanagihashi, Yuichi Ishikawa, Ken Miura, Kiyoko Murata, Takanori Takazawa, Kiyokazu Kawabe, Yasuo Iwasaki
BACKGROUND: Changes in regional cerebral blood flow (rCBF) were reported in migraineurs. However, little is known how preventive medications of migraine can influence rCBF. Lomerizine, a calcium channel blocker, has been used for migraine prophylaxis in Japan. We examined rCBF after lomerizine treatment. SUBJECTS AND METHODS: Migraine was diagnosed according to the criteria of the International Classification of Headache Disorders, Third Edition beta. Migraine subtype was classified into migraine with aura (MA) and migraine without aura (MO)...
December 5, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29221814/use-of-interventional-radiology-as-initial-hemorrhage-control-to-improve-outcomes-for-potentially-lethal-multiple-blunt-injuries
#8
Hiroyuki Otsuka, Toshiki Sato, Keiji Sakurai, Hiromichi Aoki, Takeshi Yamagiwa, Shinichi Iizuka, Sadaki Inokuchi
INTRODUCTION: Recently, trauma management has been markedly improved with interventional radiology (IVR) and damage-control strategies. However, the indications for its use in hemodynamically unstable patients with severe trauma remains unclear. In some cases, IVR may be more effective than surgery for damage-control hemostasis; however, performing IVR in life-threatening trauma settings is challenging. To address this, we practiced and evaluated a trauma-management system with emergency physicians who trained for both severe trauma management, and techniques of surgery and IVR...
December 6, 2017: Injury
https://www.readbyqxmd.com/read/29221638/d-dimer-level-correlation-with-treatment-response-in-children-with-venous-malformations
#9
Yvonne Chi-Lun Leung, Michael Wai-Yip Leung, Shi-Da Yam, Judy Wing-Suet Hung, Clarence Sze-Wai Liu, Lap-Yan Chung, Man-Yee Tang, Hon-Shing Fung, Wai-Lun Poon, Nicholas Sih-Yin Chao, Kelvin Kam-Wing Liu
AIM: Localized intravascular coagulopathy is present in children with venous malformations (VMs) as evidenced by elevated D-dimer levels. Few studies have looked into the changes in D-dimer after sclerotherapy and its correlation with treatment outcome and complications. Our study aims to investigate changes in D-dimer in children with VMs undergoing alcohol sclerotherapy. METHODS: A prospective cohort study from 2014 to 2016, which included children (<18years) with VM undergoing alcohol sclerotherapy, was completed...
November 14, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29221416/identification-of-a-new-low-energy-1u-state-in-dicopper-with-resonant-four-wave-mixing
#10
B Visser, M Beck, P Bornhauser, G Knopp, J A van Bokhoven, R Marquardt, C Gourlaouen, P P Radi
The low energy electronic structure of the copper dimer has been re-investigated using non-linear four-wave mixing spectroscopy and high level ab initio calculations. In addition to the measurement of the previously reported A, B, and C electronic states, a new state denoted A' is identified with T0 = 20 100.4090(16) cm-1 (63Cu2). Rotational analysis of the A'-X (0,0) and (1,0) transitions leads to the assignment of A' 1u. Ab initio calculations present the first theoretical description of the low energy states of the copper dimer in Hund's case (c) and confirm the experimental assignment...
December 7, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29221408/exploring-a-multi-scale-method-for-molecular-simulation-in-continuum-solvent-model-explicit-simulation-of-continuum-solvent-as-an-incompressible-fluid
#11
Li Xiao, Ray Luo
We explored a multi-scale algorithm for the Poisson-Boltzmann continuum solvent model for more robust simulations of biomolecules. In this method, the continuum solvent/solute interface is explicitly simulated with a numerical fluid dynamics procedure, which is tightly coupled to the solute molecular dynamics simulation. There are multiple benefits to adopt such a strategy as presented below. At this stage of the development, only nonelectrostatic interactions, i.e., van der Waals and hydrophobic interactions, are included in the algorithm to assess the quality of the solvent-solute interface generated by the new method...
December 7, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29221382/detailed-balance-internal-consistency-and-energy-conservation-in-fragment-orbital-based-surface-hopping
#12
Antoine Carof, Samuele Giannini, Jochen Blumberger
We have recently introduced an efficient semi-empirical non-adiabatic molecular dynamics method for the simulation of charge transfer/transport in molecules and molecular materials, denoted fragment orbital-based surface hopping (FOB-SH) [J. Spencer et al., J. Chem. Phys. 145, 064102 (2016)]. In this method, the charge carrier wavefunction is expanded in a set of charge localized, diabatic electronic states and propagated in the time-dependent potential due to classical nuclear motion. Here we derive and implement an exact expression for the non-adiabatic coupling vectors between the adiabatic electronic states in terms of nuclear gradients of the diabatic electronic states...
December 7, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29221209/direct-hpv-e6-myc-interactions-induce-histone-modifications-pol-ii-phosphorylation-and-htert-promoter-activation
#13
Yiyu Zhang, Aleksandra Dakic, Renxiang Chen, Yuhai Dai, Richard Schlegel, Xuefeng Liu
Human Papillomavirus Viruses (HPVs) are associated with the majority of human cervical and anal cancers and 10-30% of head and neck squamous carcinomas. E6 oncoprotein from high risk HPVs interacts with the p53 tumor suppressor protein to facilitate its degradation and increases telomerase activity for extending the life span of host cells. We published previously that the Myc cellular transcription factor associates with the high-risk HPV E6 protein in vivo and participates in the transactivation of the hTERT promoter...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29220548/haem-oxygenase-a-functionally-diverse-enzyme-of-photosynthetic-organisms-and-its-role-in-phytochrome-chromophore-biosynthesis-cellular-signalling-and-defence-mechanisms
#14
REVIEW
Lovely Mahawar, G S Shekhawat
Haem oxygenase (HO) is a universal enzyme that catalyzes stereospecific clevage of haem to BV IX α and liberates Fe+2 ion and CO as byproduct. Beside haem degradation, it has important functions in plants that include cellular defence, stomatal regulation, iron mobilization, phytochrome chromophore synthesis and lateral root formation. Phytochromes are an extended family of photoreceptors with a molecular mass of 250 kDa and occur as a dimer made up of two equivalent subunits of 125 kDa each. Each subunit is made of two components; the chromophore, a light capturing pigment molecule and the apoprotein...
December 8, 2017: Plant, Cell & Environment
https://www.readbyqxmd.com/read/29220409/acquisition-of-functions-on-the-outer-capsid-surface-during-evolution-of-double-stranded-rna-fungal-viruses
#15
Carlos P Mata, Daniel Luque, Josué Gómez-Blanco, Javier M Rodríguez, José M González, Nobuhiro Suzuki, Said A Ghabrial, José L Carrascosa, Benes L Trus, José R Castón
Unlike their counterparts in bacterial and higher eukaryotic hosts, most fungal viruses are transmitted intracellularly and lack an extracellular phase. Here we determined the cryo-EM structure at 3.7 Å resolution of Rosellinia necatrix quadrivirus 1 (RnQV1), a fungal double-stranded (ds)RNA virus. RnQV1, the type species of the family Quadriviridae, has a multipartite genome consisting of four monocistronic segments. Whereas most dsRNA virus capsids are based on dimers of a single protein, the ~450-Å-diameter, T = 1 RnQV1 capsid is built of P2 and P4 protein heterodimers, each with more than 1000 residues...
December 8, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/29220372/the-monomeric-form-of-neisseria-dna-mimic-protein-dmp19-prevents-dna-from-binding-to-the-histone-like-hu-protein
#16
Ming-Fen Huang, Shin-Jen Lin, Tzu-Ping Ko, Yi-Ting Liao, Kai-Cheng Hsu, Hao-Ching Wang
DNA mimicry is a direct and effective strategy by which the mimic competes with DNA for the DNA binding sites on other proteins. Until now, only about a dozen proteins have been shown to function via this strategy, including the DNA mimic protein DMP19 from Neisseria meningitides. We have shown previously that DMP19 dimer prevents the operator DNA from binding to the transcription factor NHTF. Here, we provide new evidence that DMP19 monomer can also interact with the Neisseria nucleoid-associated protein HU...
2017: PloS One
https://www.readbyqxmd.com/read/29220186/detection-of-co2%C3%A2-in-the-electrochemical-reduction-of-carbon-dioxide-in-dmf-by-scanning-electrochemical-microscopy
#17
Tianhan Kai, Min Zhou, Zhiyao Duan, Graeme A Henkelman, Allen J Bard
The electrocatalytic reduction of CO2 has been studied extensively and produces a number of products. The initial reaction in the CO2 reduction is often taken to be the 1e formation of the radical anion, CO2·. However, the electrochemical detection and characterization of CO2· is challenging because of the short lifetime of CO2·, which can dimerize and react with proton donors and even mild oxidants. Here, we report the generation and quantitative determination of CO2· in N,N-dimethyl formamide (DMF) with the tip generation/substrate collection (TG/SC) mode of scanning electrochemical microscopy (SECM)...
December 8, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29219946/c1206-a-novel-curcumin-derivative-potently-inhibits-hsp90-and-human-chronic-myeloid-leukemia-cells-in-vitro
#18
Ying-Juan Fan, Yi-Xiang Zhou, Lian-Ru Zhang, Qiao-Fa Lin, Ping-Zhang Gao, Fang Cai, Li-Ping Zhu, Bi Liu, Jian-Hua Xu
4-(4-Pyridinyl methylene) curcumin (C1206) is a new derivative of curcumin that is more active than curcumin in inhibition of heat shock protein 90 (Hsp90) and antitumor action. In this study we investigated the relationship between C1206-induced inhibition of Hsp90 and its anti-leukemic effects. The fluorescence quenching experiments showed that C1206 seemed to bind the middle dimerization domain of Hsp90. The interaction between C1206 and Hsp90 was driven mainly by electrostatic interaction. In in vitro enzyme activity assay, C1206 dose-dependently inhibited Hsp90 ATPase activity with an IC50 value of 4...
December 7, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29219827/venous-thrombosis-and-coagulation-parameters-in-patients-with-pure-venous-malformations
#19
J van Es, N A Kappelhof, R A Douma, J C M Meijers, V E A Gerdes, C M A M van der Horst
INTRODUCTION: Venous malformations (VMs) are ubiquitous, low-flow vascular anomalies known to be occasionally painful due to thrombotic episodes within the lesion. The prevalence of superficial or deep vein thrombosis is unclear. METHODS: A cross-sectional study among outpatients aged ≥ 12 years with pure VMs was performed, quantifying the prevalence of thrombosis by screening all patients with compression ultrasonography (CUS). Additionally, we evaluated whether coagulation alterations were related to thrombosis observed with CUS...
October 2017: Netherlands Journal of Medicine
https://www.readbyqxmd.com/read/29217824/soluble-tau-has-devastating-effects-on-the-structural-plasticity-of-hippocampal-granule-neurons
#20
M Bolós, N Pallas-Bazarra, J Terreros-Roncal, J R Perea, J Jurado-Arjona, J Ávila, M Llorens-Martín
Tau is a neuronal microtubule-associated protein with countless physiological functions. Although the detrimental effects of insoluble aggregated Tau have been widely studied, recent evidence supports the notion that soluble Tau (composed mostly of monomers and dimers) is also toxic for neurons. Here we evaluated the long-term impact of a single stereotaxic injection of human soluble Tau on hippocampal granule neurons in mice. At the ultrastructural level, soluble Tau reduced the number of afferent synapses and caused a dramatic depletion of synaptic vesicles both in afferent and efferent synapses...
December 8, 2017: Translational Psychiatry
keyword
keyword
58483
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"