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Nasal asthma biomarkers

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https://www.readbyqxmd.com/read/27817798/advances-in-rhinitis-and-rhinosinusitis-in-2015
#1
REVIEW
Claus Bachert, Elien Gevaert
The last year has seen great progress in the understanding of upper airway disease and in its management. For allergic rhinitis, authors focused on the prediction of and effect on the natural course of disease. New evidence was published for the disease-modifying effect of allergen immunotherapy in terms of avoidance of new sensitizations and prevention of asthma in either randomized or real-life studies. Specifically, for patients with house dust mite allergies, which are often underestimated and difficult to diagnose, the efficacy of SQ house dust mite sublingual immunotherapy tablets has been demonstrated in patients with allergic rhinitis and asthma...
November 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27582399/using-periostin-as-a-biomarker-in-the-treatment-of-asthma
#2
REVIEW
Kenji Izuhara, Shoichiro Ohta, Junya Ono
Periostin acts both as an extracellular matrix protein belonging to the fasciclin family and as a matricellular protein functioning in cell activation by binding to its receptors on the cell surface. It has been established that periostin is a downstream molecule of interleukin (IL)-13, a signature type 2 cytokine, and that periostin plays an important role in the pathogenesis of allergic diseases, including asthma. Based on these findings, much attention has been paid to periostin as a biomarker useful in the treatment of asthma...
November 2016: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/27477800/low-grade-disease-activity-in-early-life-precedes-childhood-asthma-and-allergy
#3
Bo Lund Krogsgaard Chawes
Asthma and allergies are today the most common chronic diseases in children and the leading causes of school absences, chronic medication usage, emergency department visits and hospitalizations, which affect all members of the family and represent a significant societal and scientific challenge. These highly prevalent disorders are thought to originate from immune distortion in early childhood, but the etiology and heterogeneity of the disease mechanisms are not understood, which hampers preventive initiatives and makes treatment inadequate...
August 2016: Danish Medical Journal
https://www.readbyqxmd.com/read/27393772/infectious-chronic-rhinosinusitis
#4
REVIEW
Sumit Bose, Leslie C Grammer, Anju T Peters
Chronic rhinosinusitis (CRS) is a persistent inflammatory disease that affects a multitude of people worldwide. The pathogenesis of CRS involves many factors including genetics, status of the sinonasal microbiome, infections, and environmental influences. Comorbidities associated with CRS include asthma, allergic rhinitis, bronchiectasis, and certain kinds of immunodeficiency. CRS can be divided into different subtypes based on endotypes and phenotypes. Infectious CRS is one such category. The etiology of infectious CRS is usually secondary to chronic bacterial infection that commonly begins with a viral upper respiratory tract infection...
July 2016: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/27393770/chronic-rhinosinusitis-with-nasal-polyps
#5
Whitney W Stevens, Robert P Schleimer, Robert C Kern
Chronic rhinosinusitis with nasal polyps (CRSwNP) is an important clinical entity diagnosed by the presence of both subjective and objective evidence of chronic sinonasal inflammation. Symptoms include anterior or posterior rhinorrhea, nasal congestion, hyposmia, and/or facial pressure or pain that last for a duration of more than 12 weeks. Nasal polyps are inflammatory lesions that project into the nasal airway, are typically bilateral, and originate from the ethmoid sinus. Males are more likely to be affected than females, but no specific genetic or environmental factors have been strongly linked to the development of this disorder to date...
July 2016: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/27173434/peripheral-blood-eosinophilia-correlates-with-hyperplastic-nasal-polyp-growth
#6
Virginia E Drake, Nicholas Rafaels, Jean Kim
BACKGROUND: Eosinophils are thought to play a significant role in nasal polyposis, but the exact mechanism by which they contribute to polyposis remains unclear. Therefore, we proposed to test the hypothesis that peripheral blood eosinophilia (PBE) is a surrogate and biomarker for polyp load. To do this, we examined whether PBE levels correlate with nasal polyp load in a longitudinal manner. METHODS: We retrospectively analyzed the fluctuation of PBE and nasal polyp load in each patient (n = 61) assessed preoperatively, 1-2 months postoperatively, and 3-12 months postoperatively...
September 2016: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/27130714/a-randomized-controlled-trial-of-the-effect-of-broccoli-sprouts-on-antioxidant-gene-expression-and-airway-inflammation-in-asthmatics
#7
Kuladeep Sudini, Gregory B Diette, Patrick N Breysse, Meredith C McCormack, Deborah Bull, Shyam Biswal, Shuyan Zhai, Nga Brereton, Roger D Peng, Elizabeth C Matsui
BACKGROUND: Broccoli sprouts (BS) are the richest source of sulforaphane (SFN), which is a potent inducer of phase II enzymes, which play a critical role in preventing oxidative stress (OS) and inflammation. OBJECTIVES: The objective of this study was to determine if ingestion of whole BS improves airway inflammatory and physiologic outcomes, and OS in adults with asthma and allergic sensitization to an indoor allergen. METHODS: The study is a double-blind, placebo-controlled, randomized trial to compare the effects of BS with placebo (alfalfa sprouts [AS]) on airway inflammation and markers of OS...
September 2016: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/27103607/is-there-a-future-for-biologics-in-the-management-of-chronic-rhinosinusitis
#8
REVIEW
Kent Lam, Robert C Kern, Amber Luong
BACKGROUND: Chronic rhinosinusitis (CRS) is a heterogeneous inflammatory condition of the sinonasal mucosa consisting of poorly defined subtypes and characterized by variable clinical manifestations, responses to therapy, and underlying pathophysiologies. In the related disorder of asthma, progress has been made in defining disease subtypes on both clinical and pathophysiologic levels, facilitating the development of targeted biologic pharmacotherapy. The potential role of these drugs for the management of CRS will be reviewed...
September 2016: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/26949058/inflammatory-endotypes-of-chronic-rhinosinusitis-based-on-cluster-analysis-of-biomarkers
#9
Peter Tomassen, Griet Vandeplas, Thibaut Van Zele, Lars-Olaf Cardell, Julia Arebro, Heidi Olze, Ulrike Förster-Ruhrmann, Marek L Kowalski, Agnieszka Olszewska-Ziąber, Gabriele Holtappels, Natalie De Ruyck, Xiangdong Wang, Cornelis Van Drunen, Joaquim Mullol, Peter Hellings, Valerie Hox, Elina Toskala, Glenis Scadding, Valerie Lund, Luo Zhang, Wytske Fokkens, Claus Bachert
BACKGROUND: Current phenotyping of chronic rhinosinusitis (CRS) into chronic rhinosinusitis with nasal polyps (CRSwNP) and chronic rhinosinusitis without nasal polyps (CRSsNP) might not adequately reflect the pathophysiologic diversity within patients with CRS. OBJECTIVE: We sought to identify inflammatory endotypes of CRS. Therefore we aimed to cluster patients with CRS based solely on immune markers in a phenotype-free approach. Secondarily, we aimed to match clusters to phenotypes...
May 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/26709124/suppressive-activity-of-quercetin-on-periostin-functions-in-vitro
#10
Shinji Irie, Misako Kashiwabara, Asako Yamada, Kazuhito Asano
Periostin, a 90-kDa extracellular matrix protein, has been attracting attention as a novel biomarker of airway inflammatory diseases such as allergic rhinitis (AR) and asthma. Although oral administration of quercetin to patients with AR can favorably modify the clinical condition of this disease, the influence of quercetin on periostin functions is not well understood. The present study was, therefore, undertaken to examine the influence of quercetin on the production of both periostin and periostin-induced eosinophil chemoattractants from human nasal epithelial cells (HNEpC) in vitro...
January 2016: In Vivo
https://www.readbyqxmd.com/read/26143180/increased-expression-of-the-epithelial-anion-transporter-pendrin-slc26a4-in-nasal-polyps-of-patients-with-chronic-rhinosinusitis
#11
Sudarshan Seshadri, Xiang Lu, Matthew R Purkey, Tetsuya Homma, Andrew Wonho Choi, Roderick Carter, Lydia Suh, James Norton, Kathleen E Harris, David B Conley, Atsushi Kato, Pedro C Avila, Barbara Czarnocka, Peter A Kopp, Anju T Peters, Leslie C Grammer, Rakesh K Chandra, Bruce K Tan, Zheng Liu, Robert C Kern, Robert P Schleimer
BACKGROUND: Chronic rhinosinusitis (CRS) is a multifactorial disease of unknown cause characterized by sinonasal inflammation, increased mucus production, and defective mucociliary clearance. Expression of Pendrin, an epithelial anion transporter, is increased in asthma and chronic obstructive pulmonary disease. Pendrin increases mucus production and regulates mucociliary clearance. OBJECTIVES: We sought to investigate the expression of pendrin and the mucus-related protein Muc5AC in sinonasal tissues of control subjects and patients with CRS and to evaluate the regulation of pendrin expression in nasal epithelial cells (NECs) in vitro...
December 2015: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/26134430/clinical-and-biological-markers-of-difficult-to-treat-severe-chronic-rhinosinusitis
#12
REVIEW
Mauricio López-Chacón, Joaquim Mullol, Laura Pujols
Chronic rhinosinusitis (CRS) is a chronic inflammatory disease of the upper airways of which two major phenotypes exist, CRS without nasal polyps (CRSsNP) and CRS with nasal polyps (CRSwNP). Some patients with CRS have suboptimal response to current guideline treatments. These patients remain severe and uncontrolled by treatment and have a poor quality of life. It is highly important to identify both clinical and biological markers, so-called biomarkers, in this subset of patients. The presence of nasal polyps and comorbidity with asthma and with aspirin-exacerbated respiratory disease (AERD) are the most common clinical traits that have been associated to difficult-to-treat severe CRS...
May 2015: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/25961390/airway-molecular-endotypes-of-asthma-dissecting-the-heterogeneity
#13
REVIEW
Agata Wesolowska-Andersen, Max A Seibold
PURPOSE OF REVIEW: This review will cover advances over the past year in defining airway endotypes in asthma by gene expression and the relationship between these endotypes and clinical traits. RECENT FINDINGS: Expression profiling studies of asthmatic airway samples continue to reveal significant heterogeneity in airway inflammation and dysfunction. Recent studies have indicated multiple distinct, but related Th2 inflammatory asthma endotypes. Moreover, novel biomarkers of Th2 inflammation are being identified in more accessible nasal brushing and induced sputum cell samples...
April 2015: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/25910714/vanin-1-expression-and-methylation-discriminate-pediatric-asthma-corticosteroid-treatment-response
#14
Chang Xiao, Jocelyn M Biagini Myers, Hong Ji, Kelly Metz, Lisa J Martin, Mark Lindsey, Hua He, Racheal Powers, Ashley Ulm, Brandy Ruff, Mark B Ericksen, Hari K Somineni, Jeffrey Simmons, Richard T Strait, Carolyn M Kercsmar, Gurjit K Khurana Hershey
BACKGROUND: There is considerable heterogeneity in asthma treatment response. OBJECTIVE: We sought to identify biomarkers of corticosteroid treatment response in children with asthma and evaluate the utility and mechanistic basis of these biomarkers. METHODS: Children (5-18 years) presenting to the emergency department with an acute asthma exacerbation were recruited and followed during hospitalization. Nasal epithelial cells were collected on presentation to the emergency department (T0) and 18 to 24 hours later (T1), and T1/T0 gene expression ratios were analyzed to identify genes associated with good and poor corticosteroid treatment response phenotypes...
October 2015: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/25866628/novel-clc3-transcript-variants-in-blood-eosinophils-and-increased-clc3-expression-in-nasal-lavage-and-blood-eosinophils-of-asthmatics
#15
Rohit Gaurav, Againdra K Bewtra, Devendra K Agrawal
Eosinophilia is a characteristic feature of allergic airway inflammation and remodeling. Chloride channel-3 (CLC3) in eosinophils has been associated with superoxide generation and respiratory burst. The CLC3 gene may produce multiple transcript variants through alternative splicing. However, the presence of CLC3 variants in human eosinophils is unknown. We examined the expression of CLC3 transcript variants in peripheral blood eosinophils of allergic asthmatics and healthy individuals. Potential of these obligatory dimers to form homo- or hetero-dimers was examined in HEK293 cells co-transfected with CLC3b-GFP and CLC3e-RFP...
December 2014: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/25838094/phenotype-of-asthma-related-with-high-serum-periostin-levels
#16
Masako Matsusaka, Hiroki Kabata, Koichi Fukunaga, Yusuke Suzuki, Katsunori Masaki, Takao Mochimaru, Fumio Sakamaki, Yoshitaka Oyamada, Takashi Inoue, Tsuyoshi Oguma, Koichi Sayama, Hidefumi Koh, Morio Nakamura, Akira Umeda, Junya Ono, Shoichiro Ohta, Kenji Izuhara, Koichiro Asano, Tomoko Betsuyaku
BACKGROUND: Asthma is a heterogeneous disease composed of various phenotypes. Periostin, a molecule inducible with interleukin (IL)-4 or IL-13 in bronchial epithelial cells, is a biomarker of "TH2-high" asthma. The objective of this study is to examine whether the serum periostin concentrations are correlated with the severity, specific phenotype(s), or comorbidity of asthma. METHODS: Serum concentrations of periostin were measured in 190 Japanese asthmatic patients and 11 healthy controls...
April 2015: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/25651905/emerging-biologics-for-the-treatment-of-chronic-rhinosinusitis
#17
REVIEW
Bauke Pauwels, Karin Jonstam, Claus Bachert
Chronic rhinosinusitis (CRS) is a prevalent chronic inflammatory disease of the nasal and paranasal cavities and is known to seriously impair quality of life in affected patients. CRS appears to be a heterogeneous group of diseases with different inflammatory and remodeling patterns, suggesting that not only different clinical phenotypes but also pathophysiological endotypes occur. CRS with nasal polyps (CRSwNP) is considered a more severe phenotype, especially when associated with comorbid asthma, as patients having this condition often do not respond to conventional treatment, including topical and systemic corticosteroids or surgery...
March 2015: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/25641850/gram-negative-bacterial-carriage-in-chronic-rhinosinusitis-with-nasal-polyposis-is-not-associated-with-more-severe-inflammation
#18
Paul Tabet, Leandra Mfuna Endam, Pierre Boisvert, Louis-Philippe Boulet, Martin Desrosiers
BACKGROUND: We have previously demonstrated that persistent symptoms following functional endoscopic sinus surgery for chronic rhinosinusitis (CRS) is associated with Gram-negative bacterial carriage. Mechanisms for this remain unknown. We wished to determine whether Gram-negative carriage in patients with CRS with nasal polyposis is associated with a more severe inflammatory phenomenon. METHODS: Three hundred and thirty-seven patients with CRS with nasal polyposis (CRSwNP) previously phenotyped for genetic association studies with questionnaire, serum biomarkers, and endoscopically-obtained swab cultures were studied...
April 2015: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/25624848/evaluation-of-eicosanoids-in-nasal-lavage-as-biomarkers-of-inflammation-in-patients-with-allergic-rhinitis
#19
Maciej Ciebiada, Paweł Górski, Adam Antczak
INTRODUCTION: Cysteinyl leukotrienes (cys-LTs), 8-isoprostane and prostaglandin E2 (PGE2) constitute fundamental mediators in allergic inflammation; therefore we wanted to determine the utility of PGE2, 8-isoprostane and cys-LT levels in nasal lavage as biomarkers of allergic inflammation. MATERIAL AND METHODS: Twenty-one patients with allergic rhinitis (AR) were included on the basis of a positive history of AR symptoms and positive results of skin prick tests to grass pollen allergens...
December 22, 2014: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/25592153/dipeptidyl-peptidase-10-as-a-genetic-biomarker-for-the-aspirin-exacerbated-respiratory-disease-phenotype
#20
Seung-Hyun Kim, Hyunna Choi, Moon-Gyung Yoon, Young-Min Ye, Hae-Sim Park
BACKGROUND: Aspirin-exacerbated respiratory disease (AERD) is an endotype of severe and eosinophilic adult asthma characterized by chronic rhinosinusitis with nasal polyps and hypersensitivity to aspirin and/or nonsteroidal anti-inflammatory drugs. A genetic contribution of dipeptidyl-peptidase 10 (DPP10) to asthma susceptibility and lung function decline has been reported. However, little is known about the role of DPP10 in the pathogenesis of AERD. OBJECTIVE: To identify genetic variants of DPP10 that confer susceptibility to AERD or severe asthma...
March 2015: Annals of Allergy, Asthma & Immunology
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