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https://www.readbyqxmd.com/read/28186109/astragali-radix-could-it-be-an-adjuvant-for-oxaliplatin-induced-neuropathy
#1
Lorenzo Di Cesare Mannelli, Alessandra Pacini, Laura Micheli, Angelo Pietro Femia, Mario Maresca, Matteo Zanardelli, Alfredo Vannacci, Eugenia Gallo, Anna Rita Bilia, Giovanna Caderni, Fabio Firenzuoli, Alessandro Mugelli, Carla Ghelardini
Neurotoxicity is a major side effect of platinum derivatives both during and after treatment. In the absence of effective pharmacological compounds, the opportunity to identify safe adjuvant treatments among medicinal plants seems appropriate. Astragali radix is an adaptogenic herbal product recently analyzed in platinum-treated cancer patients. With the aim of evaluating the anti-neuropathic profile of Astragali radix, a previously characterized aqueous (Aqu) and two hydroalcoholic (20%HA and 50%HA) extracts were tested in a rat model of oxaliplatin-induced neuropathy...
February 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28185988/effects-of-nonsteroidal-anti-inflammatory-drugs-on-the-renal-excretion-of-indoxyl-sulfate-a-nephro-cardiovascular-toxin-in-rats
#2
Chung-Ping Yu, Douglas H Sweet, Yu-Hsuan Peng, Yow-Wen Hsieh, Pei-Dawn Lee Chao, Yu-Chi Hou, Shiuan-Pey Lin
Chronic kidney disease (CKD) is a health problem worldwide. Indoxyl sulfate (IS) is a nephro-cardiovascular toxin accumulated in CKD patients and cannot be removed through hemodialysis. The renal excretion of IS was mediated by organic anion transporters (OATs) OAT 1 and OAT 3. Because a number of nonsteroidal anti-inflammatory drugs (NSAIDs) have been reported to inhibit OATs, we hypothesize that NSAIDs might inhibit the renal excretion of IS. Rats were intravenously injected IS with and without diclofenac, ketoprofen or salicylic acid, individually...
February 7, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28176633/hypothyroidism-and-nephrotic-syndrome-why-when-and-how-to-treat
#3
Francesca Di Mario, Riccardo Pofi, Antonietta Gigante, Laura Rivoli, Edoardo Rosato, Andrea Maria Isidori, Rosario Cianci, Biagio Barbano
Hypothyroidism, characterised by low/normal free thyroxine (FT4) and free tri-iodothyronine (FT3) with elevated thyroid-stimulating hormone (TSH), is a well-known complication of nephrotic syndrome (NS). This is a common feature of primary and secondary glomerular diseases and comprises loss of protein in the urine and increased urinary excretion of thyroid hormones and thyroxine-binding globulin. With a normal thyroid reserve, this scenario is associated with the development of subclinical hypothyroidism, with a slight increase in TSH and normal free fractions...
February 7, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28149023/status-of-serum-calcium-vitamin-d-and-parathyroid-hormone-and-hematological-indices-among-lead-exposed-jewelry-workers-in-dhaka-bangladesh
#4
I Mazumdar, K Goswami, Md Suhrab Ali
Jewelry utilizes lead either directly or as a base metal. Costume jewelry requires lead before molding and plating the product with valuable metals. Therefore, such ornaments have a great potential to release heavy metals having health hazards. Also, jewelry makers engaged in preparing German silver, an alloy, apply lead in smelting, alloying, rolling and milling silver wires and pieces. The metal is taken up by blood, soft tissues and bone. The biological effects of lead are dependent upon the level and duration of exposure...
March 2017: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/28120721/progranulin-a-new-adipokine-at-the-crossroads-of-metabolic-syndrome-diabetes-dyslipidemia-and-hypertension
#5
Agnieszka Korolczuk, Jerzy Bełtowski
BACKGROUND: Progranulin is a multifunctional regulatory protein with growth-promoting, neuroprotective and antiinflammatory activities. Recent studies indicate that progranulin is one of the adipose tissue hormones (adipokines). Progranulin expression in visceral adipose tissue and circulating progranulin concentration are increased in obesity and hyperprogranulinemia is involved in the pathogenesis of obesity-associated insulin resistance. Progranulin impairs insulin signaling and reduces insulin-induced glucose uptake both in vitro and in vivo whereas progranulin deficiency protects from high fat diet-induced insulin resistance...
January 24, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28098182/nephro-toxic-effects-of-intraperitoneally-injected-egcg-in-diabetic-mice-involvement-of-oxidative-stress-inflammation-and-apoptosis
#6
Nora O Abdel Rasheed, Lamiaa A Ahmed, Dalaal M Abdallah, Bahia M El-Sayeh
Epigallocatechin gallate (EGCG) has been studied for its beneficial effects. However, some case reports have associated EGCG supplementation with hepato-toxicity. In the present study, we investigated the possible nephro-toxic effects of EGCG in diabetic mice. Streptozotocin (150 mg/kg, i.p.) was injected in mice for diabetes induction. EGCG (100 mg/kg/day, i.p.) was then given for 4 days. The administration of EGCG to diabetic mice caused 60% mortality with no death recorded in other groups. Blood samples were collected for estimation of serum cystatin C, neutrophil gelatinase-associated lipocalin and blood urea nitrogen...
January 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28070651/inferior-vena-cava-involvement-in-children-with-wilms-tumor
#7
Abeer Al Diab, Nader Hirmas, Abdellatif Almousa, Ramiz Abu-Hijlih, Fatinah Aljlouni, Iyad Sultan, Khalil Ghandour
OBJECTIVES: Retrospective review of children with WT thrombus involving the IVC. METHODS: We reviewed the charts of 123 patients with WT diagnosed between January 2006 and December 2015. Patients with caval tumor thrombus were identified, demographic data, radiological images, extent of thrombus, chemo- and radiotherapy, surgical approach, pathology reports and outcomes were analyzed. RESULTS: IVC involvement was identified in 11 patients (9%)...
January 9, 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/28011230/sglt-2-inhibitors-their-pleiotropic-properties
#8
REVIEW
Natalia G Vallianou, Eleni Geladari, Christos E Kazazis
Type 2 diabetes mellitus has become a global pandemic. Nowadays, it is estimated that approximately 415 million people all over the world have diabetes. The sodium glucose co-transporters 2 inhibitors are a new class of glucose-lowering agents, which act through a novel mechanism by producing a decline in glucose re-absorption in the kidney, thereby increasing glycosuria and decreasing serum glucose levels. Data suggest that apart from lowering HbA1c, they produce a small but significant weight loss and a small decrease in blood pressure...
December 9, 2016: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/27932480/magi2-mutations-cause-congenital-nephrotic-syndrome
#9
Agnieszka Bierzynska, Katrina Soderquest, Philip Dean, Elizabeth Colby, Ruth Rollason, Caroline Jones, Carol D Inward, Hugh J McCarthy, Michael A Simpson, Graham M Lord, Maggie Williams, Gavin I Welsh, Ania B Koziell, Moin A Saleem
Steroid-resistant nephrotic syndrome (SRNS), a heterogeneous disorder of the renal glomerular filtration barrier, results in impairment of glomerular permselectivity. Inheritance of genetic SRNS may be autosomal dominant or recessive, with a subset of autosomal recessive SRNS presenting as congenital nephrotic syndrome (CNS). Mutations in 53 genes are associated with human SRNS, but these mutations explain ≤30% of patients with hereditary cases and only 20% of patients with sporadic cases. The proteins encoded by these genes are expressed in podocytes, and malfunction of these proteins leads to a universal end point of podocyte injury, glomerular filtration barrier disruption, and SRNS...
December 8, 2016: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/27930976/nephro-protective-effect-of-a-novel-formulation-of-unopened-coconut-inflorescence-sap-powder-on-gentamicin-induced-renal-damage-by-modulating-oxidative-stress-and-inflammatory-markers
#10
Svenia P Jose, Asha S, Krishnakumar Im, Ratheesh M, Savitha Santhosh, Sandya S, Girish Kumar B, Pramod C
Fresh oyster white translucent sap obtained from the tender unopened inflorescence of coconut trees (Cocos nucifera) is identified to have great health benefits. Drug induced Nephrotoxicity is one of the major causes of renal damage in present generation. As a therapeutic agent, gentamicin imparts direct toxicity to kidney, resulting in acute tubular necrosis, glomerular and tubulointerstitial injury, haemodynamically mediated damage and obstructive nephropathy.There exists an increasing demand for safe and natural agents for the treatment and/or preventionofchronic nephrotoxicity and pathogenesis of kidney diseases...
January 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27847198/ginsenoside-rb1-ameliorates-lithium-induced-nephrotoxicity-and-neurotoxicity-differential-regulation-of-cox-2-pge2-pathway
#11
Azza A K El-Sheikh, Maha Y Kamel
To investigate the effect of Ginsenoside-Rb1 (GRb1) on lithium (Li(+))-induced toxicity, GRb1 was given to rats orally (100mg/kg) for 14days. In independent groups, lithium chloride (4meq/kg/day i.p.) was administered at day 4 of the experiment for 10days, with or without GRb1. Li(+) caused significant deterioration of behavioral responses including righting reflex, spontaneous motor activity and catalepsy. Li(+) also caused distortion in normal renal, cerebral and cerebellum architecture and significantly worsened all kidney functional parameters tested compared to control...
December 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27805928/development-of-a-simple-and-rapid-method-to-measure-the-free-fraction-of-tacrolimus-in-plasma-using-ultrafiltration-and-lc-ms-ms
#12
Nicolaas A Stienstra, Maaike A Sikma, Anouk L van Dapperen, Dylan W de Lange, Erik M van Maarseveen
BACKGROUND: Tacrolimus is an immunosuppressant mainly used in the prophylaxis of solid organ transplant rejection. Therapeutic drug monitoring of tacrolimus is essential for avoiding toxicity related to overexposure and transplant rejection from underexposure. Previous studies suggest that unbound tacrolimus concentrations in the plasma may serve as a better predictor of tacrolimus-associated nephrotoxicity and neurotoxicity compared to tacrolimus concentration in whole blood. Monitoring the plasma concentrations of unbound tacrolimus might be of interest in preventing tacrolimus-related toxicity...
December 2016: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/27753929/os-05-04-empagliflozin-exerts-cardio-and-nephro-protective-effects-in-cohen-rosenthal-diabetic-hypertensive-rats
#13
Zaid Abassi, Jonatan Leor, Natalie Landa, Firas Younis, Kenneth Hollander, Eric Mayoux, Lea Rath-Wolfson, Talma Rosenthal
OBJECTIVE: Hypertension and Diabetes commonly coexist and have been implicated in deterioration of kidneys, heart and impairment of pancreas. Empagliflozin (Empa), a selective SGLT2 inhibitor, is a new agent for treatment of diabetes via enhancing glucosuria, independent of insulin resistance. This study evaluates Empa's prophylactic beneficial effect on glomerular, cardiac and pancreatic integrity, in CRDH animals. DESIGN AND METHOD: Cohen Rosenthal Diabetic Hypertensive rats (CRDH) were divided into 3 groups: A- Sugar diet (SD) + Empa, B-Sugar Diet + Veh, C-Regular Chow + Veh (Control)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27731814/ameliorative-potential-of-solanum-trilobatum-leaf-extract-and-fractions-on-lipid-profile-and-oxidative-stress-in-experimental-diabetes
#14
KhaderSyed Zameer Ahmed, Syed Zameer Ahmed Sidhra, Ponnusamy Ponmurugan, Balasubramanian Senthil Kumar
Solanum trilobatum Linn is a medicinal plants used in India from many centuries to cure various diseases. The purpose of the study is to evaluate the ameliorative potential of the ethanolic leaf extract and fractions of Solanum trilobatum (St) against alloxan induced diabetic rats. Solanum trilobatum leaf extract and fractions were administered orally at two different concentration (100-200mg/kg body weight) to alloxan induced diabetic rats. The antidiabetic efficacy was validated through various biochemical parameters, enzyme assays, renal markers and antioxidant properties were also determined...
September 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27710898/nephro-protective-action-of-p-santalinus-against-alcohol-induced-biochemical-alterations-and-oxidative-damage-in-rats
#15
Saradamma Bulle, Vaddi Damodara Reddy, Ananda Vardhan Hebbani, Pannuru Padmavathi, Chandrasekhar Challa, Pavan Kumar Puvvada, Elisha Repalle, Devanna Nayakanti, Chandrakala Aluganti Narasimhulu, Varadacharyulu Nallanchakravarthula
The present study investigated the antioxidant potential of P. santalinus heartwood methanolic extract (PSE) against alcohol-induced nephro-toxicity. The results indicated an increase in the concentration of kidney damage plasma markers, urea and creatinine with a concomitant decrease in the concentration of uric acid in alcohol-administered rats. A significant decrease in plasma electrolytes and mineral levels with increased kidney thiobarbituric acid reactive substances (TBARS) and nitric oxide (NOx) levels was also observed...
December 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27693478/dismembered-pyeloplasy-in-infants-six-months-old-or-younger-with-and-without-external-trans-anastomotic-nephrostent-a-prospective-randomized-study
#16
Farouk M Nasser, Ahmed M Shouman, Mohammed S ElSheemy, Mohammed A Lotfi, Waseem Aboulela, Mohamed El Ghoneimy, Mohammed Abdelwahab, Ahmed I Shoukry, Waleed Ghoneima, Hany Morsi, Hesham Badawy
OBJECTIVES: To compare outcome of dismembered-pyeloplasty in infants with and without external nephro-ureteric stent (ENUS) for treatment of congenital ureteropelvic junction obstruction (UPJ-O). METHODS: This is a parallel, randomized comparative study between October 2013 and September 2014. 30 infants ≤6 months old with UPJ-O indicated for dismembered-pyeloplasty were randomly assigned (block randomization, closed envelope method) into two groups; group-A (stentless) and group-B (ENUS)...
September 28, 2016: Urology
https://www.readbyqxmd.com/read/27643322/os-05-04-empagliflozin-exerts-cardio-and-nephro-protective-effects-in-cohen-rosenthal-diabetic-hypertensive-rats
#17
Zaid Abassi, Jonatan Leor, Natalie Landa, Firas Younis, Kenneth Hollander, Eric Mayoux, Lea Rath-Wolfson, Talma Rosenthal
OBJECTIVE: Hypertension and Diabetes commonly coexist and have been implicated in deterioration of kidneys, heart and impairment of pancreas. Empagliflozin (Empa), a selective SGLT2 inhibitor, is a new agent for treatment of diabetes via enhancing glucosuria, independent of insulin resistance. This study evaluates Empa's prophylactic beneficial effect on glomerular, cardiac and pancreatic integrity, in CRDH animals. DESIGN AND METHOD: Cohen Rosenthal Diabetic Hypertensive rats (CRDH) were divided into 3 groups: A- Sugar diet (SD) + Empa, B-Sugar Diet + Veh, C-Regular Chow + Veh (Control)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27640156/a-reliable-method-for-enrichment-of-neutrophils-from-peripheral-blood-in-barramundi-lates-calcarifer
#18
Kelly-Anne Masterman, Andrew C Barnes
Neutrophils are a short-lived, terminally differentiated, innate immune cell, that are critical first responders during infection. Research into neutrophil-pathogen interactions in fish has primarily employed cells derived from the pro-nephros and nephros. Since these sites are also the location of neutrophil and other immune cell development, there may be some ambiguity in maturation and functional ability of these cells, and difficulty in differentiating the effects of neutrophils from those of macrophages and monocytes...
November 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27634224/renal-and-systemic-effects-of-calorie-restriction-in-patients-with-type-2-diabetes-with-abdominal-obesity-a-randomized-controlled-trial
#19
Piero Ruggenenti, Manuela Abbate, Barbara Ruggiero, Stefano Rota, Matias Trillini, Carolina Aparicio, Aneliya Parvanova, Ilian Petrov Iliev, Giovanna Pisanu, Annalisa Perna, Angela Russo, Olimpia Diadei, Davide Martinetti, Antonio Cannata, Fabiola Carrara, Silvia Ferrari, Nadia Stucchi, Giuseppe Remuzzi, Luigi Fontana
In individuals with type 2 diabetes with abdominal obesity, hyperfiltration is a risk factor for accelerated glomerular filtration rate (GFR) decline and nephropathy. In this academic, single-center, parallel-group, prospective, randomized, open-label, blinded end point trial, consenting patients with type 2 diabetes aged >18 years, with waist circumference >94 (males) or >80 (females) cm, serum creatinine <1.2 mg/dL, and normoalbuminuria were randomized (1:1) with permuted blocks to 6 months of a 25% calorie restricted (CR) or standard diet (SD)...
January 2017: Diabetes
https://www.readbyqxmd.com/read/27598183/can-we-further-improve-the-quality-of-nephro-urological-care-in-children-with-myelomeningocele
#20
Monika Miklaszewska, Przemysław Korohoda, Katarzyna Zachwieja, Michał Wolnicki, Małgorzata Mizerska-Wasiak, Dorota Drożdż, Jacek A Pietrzyk
Myelomeningocele (MMC) results from a failure of normal neural tube fusion in early fetal development. Retrospective, observational study of medical data of 54 children treated in Pediatric Nephrology and Urology Clinics for five years was performed. The following data were analyzed: serum creatinine, eGFR, urine analysis, renal scintigraphy (RS), renal ultrasound, and urodynamics. Mean age of studied population: 12.3 years, median of eGFR at the beginning and at the end of survey was 110.25 and 116.5 mL/min/1...
2016: International Journal of Environmental Research and Public Health
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