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https://www.readbyqxmd.com/read/28741978/effects-of-co-exposure-to-atrazine-and-ethanol-on-the-oxidative-damage-of-kidney-and-liver-in-wistar-rats
#1
Sunny O Abarikwu, Queen C Duru, Rex-Clovis C Njoku, Benjamin A Amadi, Aseme Tamunoibuomie, Enebimoere Keboh
Both ethanol (EtoH) and atrazine (ATZ) have hepatic and nephro-toxic effects in rats. In the present study, the toxicity of EtoH (5 g kg(-1)) on the kidney and liver in the absence or in the presence of different doses of ATZ (50, 100, 300 mg kg(-1)) was evaluated after 21 days in rats. Results showed that the mixture effects on catalase and superoxide dismutase activities were more severe in both tissues compared to EtoH alone, especially as the dose of ATZ was increased. Hepatic malondialdehyde level (an index of lipid peroxidation) was increased from 20...
November 2017: Renal Failure
https://www.readbyqxmd.com/read/28737206/-nephro-urological-malformations-in-children-with-down-syndrome
#2
Felipe Cavagnaro
No abstract text is available yet for this article.
June 2017: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/28691739/nuclear-magnetic-resonance-and-mass-spectometry-based-metabolomics-to-study-maleic-acid-toxicity-from-repeated-dose-exposure-in-rats
#3
Charlene Wu, Chi-Hung Chen, Hsin-Chang Chen, Hao-Jan Liang, Shu-Ting Chen, Wan-Yu Lin, Kuen-Yuh Wu, Su-Yin Chiang, Ching-Yu Lin
Maleic acid (MA), a chemical intermediate used in many consumer and industrial products, was intentionally adulterated in a variety of starch-based foods and instigated food safety incidents in Asia. We aim to elucidate possible mechanisms of MA toxicity after repeated exposure by (1) determining the changes of metabolic profile using (1) H nuclear magnetic resonance spectroscopy and multivariate analysis, and (2) investigating the occurrence of oxidative stress using liquid chromatography tandem mass spectrometry by using Sprague-Dawley rat urine samples...
July 10, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/28685675/the-beneficial-effects-of-sulfur-containing-amino-acids-on-cisplatin-induced-cardiotoxicity-and-neurotoxicity-in-rodents
#4
Gvozden Rosic, Jovana Joksimovic, Dragica Selakovic, Vladimir Jakovljevic, Vladimir Zivkovic, Ivan Srejovic, Marko Djuric, Dragan Djuric
Cisplatin is one the most frequently used chemotherapeutic drugs for several decades. Although its antineoplastic effect has been reported in treatment of numerous malignances, various adverse effects seem to be the crucial limiting factor for its administration. Beside the most commonly described nephro- and hepatotoxicity, cisplatin therapy is also accompanied with gastrointestinal, reproductive, hematological, cardiovascular and neurological side effects. Since it has been reported that cisplatin induce oxidative damage in various tissues (by means of altered ROS production, as well as by depletion of antioxidants), it seems reasonable that huge efforts had been put in the investigations of antioxidant supplementation as potential therapeutical approach for attenuation of cisplatin toxicities...
July 5, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28661606/-peculiarities-of-transcutaneous-nephrolithotripsy-in-the-patient-s-position-lying-on-the-back
#5
A I Sagalevich, S A Vozianov, B V Juran, V V Kogut, F Z Gaysenyuk, R V Sergiychuk
In 2014 - 2016 yrs transcutaneous nephrolithotripsy was performed in 245 patients for nephrolithiasis, of them in 228 (93.1%) - in position of patient lying on the abdomen (1st group), in 17 (6.9%) - lying on the back (2nd group) because of various concur- rent cardio-vascular and respiratory diseases present. Mini- transcutaneous nephro- lithotripsy was performed under regional epidural anesthesia in 224 (91.4%) patients, and under endotracheal narcosis - in 21 (8.6%). While conduction of mini- transcu- taneous nephrolithotripsy in position of patient lying on the back the operation duration is reducing, and it is possible to perform simultant endoscopic interventions (trans- ureteric, transcutaneous)...
August 2016: Klinichna Khirurhiia
https://www.readbyqxmd.com/read/28604991/ureteroscopy-in-the-diagnosis-of-upper-tract-transitional-cell-cancer-a-10-year-experience-providing-outcome-data-for-informed-consent
#6
Luke Hanna, Vera Chung, Ahmed Ali, Robert Ritchie, Ann Rogers, Mark Sullivan, Stephen Keoghane
PURPOSE: The aim of the study was to assess the effectiveness of ureteroscopy and biopsy in the diagnosis and management of upper tract urothelial carcinoma. METHODS: We retrospectively collated data from pathology, radiology and operating theatre data sets from two large UK hospitals. During the 10-year period examined, 160 patients underwent ureteroscopy prior to nephro-ureterectomy (NU)/distal ureterectomy (DU). RESULTS: Of the 160 patients identified, 140 were ureteroscopically evaluated and biopsied, 104 (74...
June 7, 2017: Urologia
https://www.readbyqxmd.com/read/28543864/modulation-of-heme-oxygenase-1-expression-and-activity-affects-streptozotocin-induced-diabetic-nephropathy-in-rats
#7
Marwa A M Ali, Gehan H Heeba, Azza A K El-Sheikh
Heme oxygenase (HO)-1 has exhibited nephro-protective actions in different animal models; however, its full mechanistic potential in diabetic nephropathy (DN) has not yet been elucidated. Hence, the present study has been undertaken by inducing DN in rats using streptozotocin (50mg/kg i.p.), with or without either HO-1 inducer; hemin (HM; 40 μmol/kg, s.c.), or HO-1 blocker; zinc protoporphyrin-IX (ZnPP; 50 μmol/kg, i.p.), for one month. Compared to control, rats with DN suffered from hyperglycemia and hyperlipidemia, with signs of renal damage, as assessed by distortion in renal histopathological architecture and kidney function...
May 23, 2017: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/28490965/protective-effects-of-fennel-oil-extract-against-sodium-valproate-induced-hepatorenal-damage-in-albino-rats
#8
Wael M Al-Amoudi
Foeniculum vulgare (Apiaceae) is commonly known as fennel. This herb is well-known worldwide and traditionally used as curative herbal therapy for the treatment of epileptic disease, seizurescarminative, digestive, lactogogue, diuretic, treating respiratory and gastrointestinal disorders. The aim of present study is to investigate the possible effect of fennel oil against the toxicity of Sodium-Valproic (SVP) in albino rats. In order to assess the protection of fennel oil on SVP induced hepato- and nephro-toxicity, male albino rats were treated with 1 ml/kg b...
May 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/28440053/who-is-at-risk-of-death-from-nephrectomy-an-analysis-of-thirty-day-mortality-after-21-380-nephrectomies-in-3-years-of-the-british-association-of-urological-surgeons-baus-national-nephrectomy-audit
#9
Archie Fernando, Sarah Fowler, Mieke Van Hemelrijck, Tim O'Brien
OBJECTIVE: To ascertain contemporary overall and differential thirty-day mortality (TDM) rates after all types of nephrectomy in the UK, and to identify potential new risk factors for death. PATIENTS AND METHODS: We conducted a retrospective analysis of the 110 deaths that occurred within 30 days of surgery out of the total of 21 380 nephrectomies performed, and calculated the odds ratio (OR) and 95% confidence interval (CI) for TDM based on peri-operative characteristics...
April 24, 2017: BJU International
https://www.readbyqxmd.com/read/28417852/nuclear-medicine-in-pediatric-nephro-urology-an-overview
#10
REVIEW
Iosif Mendichovszky, Bernardita Troncoso Solar, Naima Smeulders, Marina Easty, Lorenzo Biassoni
In the context of ante-natally diagnosed hydronephrosis, the vast majority of children with a dilated renal pelvis do not need any surgical treatment, as the dilatation resolves spontaneously with time. Slow drainage demonstrated at Tc-99m-mercaptoacetyltriglycine (MAG3) renography does not necessarily mean obstruction. Obstruction is defined as resistance to urinary outflow with urinary stasis at the level of the pelvic-ureteric junction (PUJ) which, if left untreated, will damage the kidney. Unfortunately this definition is retrospective and not clinically helpful...
May 2017: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/28417195/rrx-001-protects-against-cisplatin-induced-toxicities
#11
Bryan Oronsky, Tony R Reid, Christopher Larson, Corey A Carter, Christina E Brzezniak, Arnold Oronsky, Pedro Cabrales
PURPOSE: RRx-001, a minimally toxic tumor-associated macrophage and neutrophil-repolarizing agent, is under investigation in Phase II clinical trials as a sensitizer/resensitizer to cisplatin and carboplatin. On the basis of anecdotal clinical observations of improved platinum tolerability following a priming period with RRx-001 as well as preclinical studies that have previously demonstrated radioprotection of intestinal stem cells and cardioprotection from doxorubicin, the in vivo cytoprotective potential of RRx-001 pretreatment against cisplatin-induced bone marrow suppression and renal toxicity was investigated...
April 17, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28413305/solitary-functioning-kidney-in-high-anorectal-malformation
#12
Kanishka Das, Srinivas Raju Rajkiran
AIM: A solitary functioning renal unit in high anorectal malformation may harbor anomalies in the upper/lower urinary tract that further compromise renal function and accelerate hyperfiltration injury. We aimed to analyze the clinical course, management, and outcome of children with a solitary renal unit and high anorectal malformation. MATERIALS AND METHODS: A cohort of solitary renal units in anorectal malformation managed between 2000 and 2015 with a defined protocol at a pediatric nephro-urology clinic are included in the study...
April 2017: Journal of Indian Association of Pediatric Surgeons
https://www.readbyqxmd.com/read/28409500/tissue-protective-activity-of-selenomethionine-and-d-panthetine-in-b16-melanoma-bearing-mice-under-doxorubicin-treatment-is-not-connected-with-their-ros-scavenging-potential
#13
Rostyslav R Panchuk, Nadia R Skorokhyd, Yuliya S Kozak, Liliya V Lehka, Andrey G Moiseenok, Rostyslav S Stoika
AIM: To evaluate molecular mechanisms of tissue-protective effects of antioxidants selenomethionine (SeMet) and D-pantethine (D-Pt) applied in combination with doxorubicin (Dx) in B16 melanoma-bearing-mice. METHODS: Impact of the chemotherapy scheme on a survival of tumor-bearing animals, general nephro- and hepatotoxicity, blood cell profile in vivo, and ROS content in B16 melanoma cells in vitro was compared with the action of Dx applied alone. Nephrotoxicity of the drugs was evaluated by measuring creatinine indicator assay, hepatotoxicity was studied by measuring the activity of ALT/AST enzymes, and myelotoxicity was assessed by light microscopic analysis of blood smears...
April 14, 2017: Croatian Medical Journal
https://www.readbyqxmd.com/read/28385045/long-term-outcomes-of-laparoscopic-nephroureterectomy-with-transurethral-circumferential-excision-of-the-ureteral-orifice-for-urothelial-carcinoma
#14
Aakash Pai, Muddassar Hussain, Richard Hindley, Amr Emara, Neil Barber
INTRODUCTION: When performing open or laparoscopic nephroureterectomy (LNU), the optimal way to excise the distal ureter remains controversial. There are concerns that primary endoscopic detachment of the intramural ureter is associated with adverse outcomes. Existing studies have limited number of patients and inadequate oncologic follow-up. We provide our institutions experience of this technique. MATERIALS AND METHODS: Data were collected prospectively on 59 patients (37 men) who underwent LNU for a 10-year period at a single center using a standardized technique: initial endoscopic circumferential release of the distal ureter and bladder cuff followed by retroperitoneal en bloc LNU...
July 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28355403/when-kidneys-get-old-an-essay-on-nephro-geriatrics
#15
Richard Glassock, Aleksandar Denic, Andrew D Rule
Aging is a nearly universal phenomenon in biology only partially controlled by genetic endowment. Individuals and their organs age at varying rates. The kidneys manifest the aging process by steady loss of nephrons and a corresponding decrease in glomerular filtration rate (GFR) beginning about age 30 years. The mechanisms responsible for this observation is are elusive. However, defining chronic kidney disease based on arbitrary, fixed thresholds of GFR in the later phases of life can be problematical as it may over-diagnosis CKD in the elderly...
March 2017: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/28352011/biopsy-of-small-kidneys-a-safe-and-a-useful-guide-to-potentially-treatable-kidney-disease
#16
Kamel El-Reshaid, Wael El-Reshaid, Dalal Al-Bader, Jozsef Varro, John Madda, Hosameldin Tawfik Sallam
Over the past four years, all patients with unexplained rapid progression of their renal disease were subjected to kidney biopsy, despite their small size (<9 cm), to define its etiology. Children, pregnant women, morbidly obese patients, and those with an unstable cardiovascular state, septicemia, bleeding diathesis as well as those kidney size with size <6 cm were excluded from the study. Doppler ultrasound was used to exclude renovascular/ischemic nephropathy. The procedure was performed by an interventional radiologist using a biopsy gun technique and under ultrasound guidance...
March 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28306528/protective-effect-of-moringa-oleifera-oil-against-hgcl2-induced-hepato-and-nephro-toxicity-in-rats
#17
Sunny O Abarikwu, Sussan Benjamin, Sunday Godspower Ebah, Godbless Obilor, Goodluck Agbam
BACKGROUND: Various parts of the Moringa oleifera (M. oleifera) tree are widely accepted to have ameliorative effects against metal toxicity. In the present study, M. oleifeira oil (MO) was tested against HgCl2-induced tissue pathologies and oxidative stress. METHODS: Male Wistar rats were administered MO (1.798 mg/kg p.o.) or HgCl2 (5 mg/kg body wt) alone or in combination (5 mg/kg HgCl2+1.798 mg/kg MO p.o.) three times per week for 21 days. After exposure and treatment periods, rats were sacrificed; blood collected and the oxidative status of the liver and kidney homogenates were evaluated...
July 26, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28284752/troxerutin-exerts-neuroprotection-in-6-hydroxydopamine-lesion-rat-model-of-parkinson-s-disease-possible-involvement-of-pi3k-er%C3%AE-signaling
#18
Tourandokht Baluchnejadmojarad, Nida Jamali-Raeufy, Sedigheh Zabihnejad, Nafiseh Rabiee, Mehrdad Roghani
Parkinson's disease (PD) is a neurodegenerative disease with progressive loss of mesencephalic dopaminergic neurons of the substantia nigra and with multiple incapacitating motor and non-motor symptoms. Troxerutin is a natural bioflavonoid with nephro- and hepato-protective, antioxidant, and anti-inflammatory properties. In this study, we evaluated its possible neuroprotective effect in 6-hydroxydopamine (6-OHDA) rat model of PD. Intrastriatal 6-OHDA-lesioned rats were pretreated with troxerutin at a dose of 150mg/kg/day for 1 week...
April 15, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28278585/toxicity-evaluation-of-silver-nanoparticles-synthesized-by-chemical-and-green-route-in-different-experimental-models
#19
Shakila Banu Vasanth, Gino A Kurian
With the increased exposure of silver nanoparticles (AgNPs) to human beings, the risk and safety should be considered. In this study, nephro-toxicity of AgNPs prepared by chemical and green route (aqueous extract of Desmodium gangeticum root) in rat, proximal epithelial cell lines and renal mitochondria was evaluated. AgNPs (100 mg/kg) were administered orally to the wistar rats. After 15 d, we observed significant changes in the renal architecture of both AgNPs, supported by the urine and blood chemistry data...
February 14, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28186109/astragali-radix-could-it-be-an-adjuvant-for-oxaliplatin-induced-neuropathy
#20
Lorenzo Di Cesare Mannelli, Alessandra Pacini, Laura Micheli, Angelo Pietro Femia, Mario Maresca, Matteo Zanardelli, Alfredo Vannacci, Eugenia Gallo, Anna Rita Bilia, Giovanna Caderni, Fabio Firenzuoli, Alessandro Mugelli, Carla Ghelardini
Neurotoxicity is a major side effect of platinum derivatives both during and after treatment. In the absence of effective pharmacological compounds, the opportunity to identify safe adjuvant treatments among medicinal plants seems appropriate. Astragali radix is an adaptogenic herbal product recently analyzed in platinum-treated cancer patients. With the aim of evaluating the anti-neuropathic profile of Astragali radix, a previously characterized aqueous (Aqu) and two hydroalcoholic (20%HA and 50%HA) extracts were tested in a rat model of oxaliplatin-induced neuropathy...
February 10, 2017: Scientific Reports
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