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https://www.readbyqxmd.com/read/29780204/the-short-term-dynamics-of-peers-and-delinquent-behavior-an-analysis-of-bi-weekly-changes-within-a-high-school-student-network
#1
Frank M Weerman, Pamela Wilcox, Christopher J Sullivan
Objectives: To analyze short-term changes in peer affiliations, offending behavior and routine activities in order to evaluate three different processes: peer selection, peer socialization and situational peer influences. Methods: The short-term longitudinal TEENS study was conducted among a cohort of students from one mid-sized high school in Kentucky, as part of the larger Rural Substance Abuse and Violence Project. The study sample consists of one complete network of 155 ninth graders who completed surveys about their peer affiliations, routine activities and offending behaviors over the course of five waves of data collection during the beginning of the school year...
2018: Journal of Quantitative Criminology
https://www.readbyqxmd.com/read/29765773/optimising-the-use-of-cetuximab-in-the-continuum-of-care-for-patients-with-metastatic-colorectal-cancer
#2
REVIEW
Richard M Goldberg, Clara Montagut, Zev A Wainberg, Philippe Ronga, François Audhuy, Julien Taieb, Sebastian Stintzing, Salvatore Siena, Daniele Santini
The anti-epidermal growth factor receptor (EGFR) monoclonal antibody cetuximab in combination with chemotherapy is a standard of care in the first-line treatment of RAS wild-type (wt) metastatic colorectal cancer (mCRC) and has demonstrated efficacy in later lines. Progressive disease (PD) occurs when tumours develop resistance to a therapy, although controversy remains about whether PD on a combination of chemotherapy and targeted agents implies resistance to both components. Here, we propose that some patients may gain additional clinical benefit from the reuse of cetuximab after having PD on regimens including cetuximab in an earlier treatment line...
2018: ESMO Open
https://www.readbyqxmd.com/read/29741593/glycated-peptide-levels-are-associated-with-cognitive-decline-among-non-diabetic-older-women
#3
Siena Duarte, Tina Hoang, Susan K Ewing, Peggy M Cawthon, Steve Cummings, Katie L Stone, Jane A Cauley, Douglas C Bauer, Teresa A Hillier, Kristine Yaffe
Background: The association between diabetes and dementia may be explained in part by elevated levels of glycated peptides; we sought to determine if serum glycated peptides predicted cognitive decline in non-diabetic older adults. Methods: We prospectively studied 525 community-dwelling non-diabetic women, mean age of 82 years, and analyzed baseline glycated peptides (serum level of fructosamine and glycated albumin). Cognitive outcomes included 5-year decline on the short Mini-Mental State Examination (sMMSE), Trails B, and performance on a battery of five other cognitive tests at the follow-up visit...
May 7, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29714673/measurement-of-whole-brain-and-gray-matter-atrophy-in-multiple-sclerosis-assessment-with-mr-imaging
#4
Loredana Storelli, Maria A Rocca, Elisabetta Pagani, Wim Van Hecke, Mark A Horsfield, Nicola De Stefano, Alex Rovira, Jaume Sastre-Garriga, Jacqueline Palace, Diana Sima, Dirk Smeets, Massimo Filippi
Purpose To compare available methods for whole-brain and gray matter (GM) atrophy estimation in multiple sclerosis (MS) in terms of repeatability (same magnetic resonance [MR] imaging unit) and reproducibility (different system/field strength) for their potential clinical applications. Materials and Methods The softwares ANTs-v1.9, CIVET-v2.1, FSL-SIENAX/SIENA-5.0.1, Icometrix-MSmetrix-1.7, and SPM-v12 were compared. This retrospective study, performed between March 2015 and March 2017, collected data from (a) eight simulated MR images and longitudinal data (2 weeks) from 10 healthy control subjects to assess the cross-sectional and longitudinal accuracy of atrophy measures, (b) test-retest MR images in 29 patients with MS acquired within the same day at different imaging unit field strengths/manufacturers to evaluate precision, and (c) longitudinal data (1 year) in 24 patients with MS for the agreement between methods...
May 27, 2018: Radiology
https://www.readbyqxmd.com/read/29686800/interplay-between-virulence-and-variability-factors-as-a-potential-driver-of-invasive-meningococcal-disease
#5
REVIEW
Emilio Siena, Margherita Bodini, Duccio Medini
No abstract text is available yet for this article.
2018: Computational and Structural Biotechnology Journal
https://www.readbyqxmd.com/read/29666691/internal-laryngocele-unusual-onset-in-a-91-year-old-female-patient
#6
Maria C Spinosi, Chiara Mezzedimi, Giovanni Monciatti, Desiderio Passali
While internal laryngoceles rarely cause major clinical complaints, they may lead to airway obstruction and require emergency intervention on rare occasions. We report a 91-year-old patient who was referred to the Ear, Nose & Throat Clinic of the Policlinico Santa Maria alle Scotte, Siena, Italy, in 2017 due to recurrent episodes of severe dyspnoea. A flexible nasopharyngolaryngoscopic examination revealed an internal laryngocele of approximately 1.5 cm in diameter that moved up and down the glottic plane, occasionally invading the subglottic space during inspiration and impeding airflow...
February 2018: Sultan Qaboos University Medical Journal
https://www.readbyqxmd.com/read/29659677/targeting-the-human-epidermal-growth-factor-receptor-2-her2-oncogene-in-colorectal-cancer
#7
S Siena, A Sartore-Bianchi, S Marsoni, H I Hurwitz, S J McCall, F Penault-Llorca, S Srock, A Bardelli, L Trusolino
BACKGROUND: Human epidermal growth factor receptor 2 (HER2) is an oncogenic driver, and a well-established therapeutic target in breast and gastric cancers. Using functional and genomic analyses of patient-derived xenografts, we previously showed that a subset (approximately 5%) of metastatic colorectal cancer (CRC) tumors are driven by amplification or mutation of HER2. MATERIALS AND METHODS: This paper reviews the role of HER2 as an oncogenic driver, a prognostic and predictive biomarker, and a clinically actionable target in CRC, considering the specifics of HER2 testing in this tumor type...
April 6, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29645355/the-european-experience-on-robot-assisted-kidney-transplantation-minimum-of-one-year-follow-up
#8
Angelo Territo, Lluis Gausa, Antonio Alcaraz, Mireia Musquera, Nicolas Doumerc, Karel Decaestecker, Liesbeth Desender, Michael Stockle, Martin Janssen, Paolo Fornara, Nasreldin Mohammed, Giampaolo Siena, Sergio Serni, Selcuk Sahin, Volkan Tuǧcu, Giuseppe Basile, Alberto Breda
OBJECTIVES: To evaluate functional results, graft survival, and late complications in patients who underwent robot-assisted kidney transplantation (RAKT), with a minimum follow-up of one year. In addition: to analyze the correlation between surgical data and functional results at a minimum 1-year follow-up and the correlation between renal function in the immediate postoperative period and after one year. MATERIALS AND METHODS: A common prospective recruitment database of RAKT was created by the European Robotic Urological Section (ERUS) RAKT working group, including eight different European centers...
April 12, 2018: BJU International
https://www.readbyqxmd.com/read/29628901/defending-oneself-from-tourists-the-counter-environmental-bubble
#9
Michela Cortini, Daniela Converso
According to the Environmental Bubble Theory, tourists perform a series of strategies in order to remain anchored to their residential spots. The environmental bubble is constituted by a sort of social pellicule able to immunize tourists from the identity/cultural attacks which the visit to a foreign country implies. Such a pellicule is activated by the tourists themselves as they decide to travel in group or, for example, to eat only at the restaurants proposing their own national cuisine, and so on. Generally the potential cultural shock of residents is not taken into consideration in literature, even if it is plausibile to make the hypothesis of a counter-environmental bubble performed by the residents in order to defend their own culture and their identity from the attacks of mass tourism, especially for cities that live on tourism, as, for example, Florence or Siena do...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29628438/an-aggressive-early-gastric-cancer-kodama-s-pena-type
#10
Paolo Morgagni, Leonardo Solaini, Luca Saragoni, Maria Bencivenga, Uberto Fumagalli Romario, Luigina Graziosi, Elisabetta Marino, Daniele Marrelli, Stefano Rausei, Fausto Rosa, Emanuela Scarpi, Anna Tomezzoli, Domenico Tringali, Carla Vindigni, Giovanni Vittimberga, Franco Roviello
BACKGROUND: To investigate the role of Kodama PenA subtype in influencing survival in patients with early gastric cancer (EGC). METHODS: All patients surgically treated for EGC at 7 Italian centers (Forlì, Varese, Siena, Verona, Milan, Rome and Perugia) belonging to the Italian Research Group for Gastric Cancer (GIRCG) from January 1982 and December 2009 were included. RESULTS: PenA patients were 230 (21.5%) while other types were 839 (78...
March 27, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29627309/effect-of-primary-tumor-location-on-second-or-later-line-treatment-outcomes-in-patients-with-ras-wild-type-metastatic-colorectal-cancer-and-all-treatment-lines-in-patients-with-ras-mutations-in-four-randomized-panitumumab-studies
#11
Nele Boeckx, Reija Koukakis, Ken Op de Beeck, Christian Rolfo, Guy Van Camp, Salvatore Siena, Josep Tabernero, Jean-Yves Douillard, Thierry André, Marc Peeters
BACKGROUND: The primary tumor location has a prognostic impact in metastatic colorectal cancer (mCRC). We report the results from retrospective analyses assessing the effect of tumor location on prognosis and efficacy of second- and later-line panitumumab treatment in patients with RAS wild-type (WT) mCRC and on prognosis in all lines of treatment in patients with RAS mutant (MT) mCRC. PATIENTS AND METHODS: RAS WT data (n = 483) from 2 randomized phase III panitumumab trials (ClinicalTrials...
March 8, 2018: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/29624141/management-simulations-for-lean-healthcare-exploiting-the-potentials-of-role-playing
#12
Federico Barnabè, Maria Cleofe Giorgino, Jacopo Guercini, Caterina Bianciardi, Vincenzo Mezzatesta
Purpose The purpose of this paper is to investigate the potentials of role-playing (RP) both in training healthcare (HC) professionals to implement tools and improvement actions based on Lean principles, and in supporting group discussion and the sharing of different competencies for the development of Lean HC. Design/methodology/approach The paper presents the case study of an RP simulation called LEAN HEALTHCARE LAB, which is used to train HC professionals at Siena University Hospital. The paper reports and discusses the results of a specific two-day simulation session and of a questionnaire that was distributed to gather feedback from the participants...
April 9, 2018: Journal of Health Organization and Management
https://www.readbyqxmd.com/read/29605009/troglostrongylus-brevior-a-feline-lungworm-of-paediatric-concern
#13
Maria Alfonsa Cavalera, Roberta Iatta, Vito Colella, Filipe Dantas-Torres, Angelo Corsaro, Emanuele Brianti, Domenico Otranto
The immature immune system of cats in their paediatric age (i.e., first six months of life) favours the establishment of infectious respiratory tract diseases mainly caused by well recognized viruses and bacteria species. Conversely, lungworm infections are less investigated during respiratory disorders in kittens. In the last decade, Troglostrongylus brevior has been found affecting the respiratory tract of cats, along with the better-known Aelurostrongylus abstrusus. Given the scant data available on the epidemiology of feline troglostrongylosis, faecal samples from 575 domestic animals living in three Italian municipalities (i...
April 15, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29576281/public-health-since-the-beginning-neonatal-incubators-safety-in-a-clinical-setting
#14
M Fattorini, G Buonocore, D Lenzi, S Burgassi, R M R Cardaci, K P Biermann, G Cevenini, G Messina
BACKGROUND: The role of environmental cleaning as an effective measure to contain the diffusion of Healthcare Associated Infections (HAIs) has already been demonstrated. Among medical devices, neonatal incubators have been recognized as a source of pathogens involved in the spread of HAIs. Aim of the study was to assess the efficacy of a disinfection protocol for neonatal incubators. METHODS: The cross sectional study took place in the "Neonatal Pediatric Unit" of the Teaching Hospital of Siena: twenty incubators, used for critical newborns, were swabbed in 13 sampling points before and after the implementation of the disinfection protocol...
March 22, 2018: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/29575060/real-life-3d-therapy-failure-analysis-of-ns5a-93h-ras-plus-108k-polymorphism-in-complex-with-ombitasvir-by-molecular-modeling
#15
Nadia Marascio, Grazia Pavia, Isabella Romeo, Carmine Talarico, Sebastiano Di Salvo, Mariaconcetta Reale, Vito Marano, Giorgio Settimo Barreca, Fernanda Fabiani, Nicola Perrotti, Massimo De Siena, Francesca Giancotti, Tiziana Gravina, Stefano Alcaro, Anna Artese, Carlo Torti, Maria Carla Liberto, Alfredo Focà
We report a real-life 3D therapy failure in a patient treated with ombitasvir (OMV)/paritaprevir/ritonavir and dasabuvir without ribavirin (3D-R). He had therapy failure at week 12 after the end of treatment. We detected resistance-associated substitutions (RASs) plus polymorphisms on NS3, NS5A and NS5B target regions by population sequencing (15% cut-off) at baseline, at relapse and during follow-up. About this, NS5A RASs generally persist longer than resistances in the other target genes and may impact treatment outcome...
March 25, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29560379/brain-atrophy-and-disability-worsening-in-primary-progressive-multiple-sclerosis-insights-from-the-informs-study
#16
David H Miller, Fred D Lublin, Maria Pia Sormani, Ludwig Kappos, Özgür Yaldizli, Mark S Freedman, Bruce A C Cree, Howard L Weiner, Catherine Lubetzki, Hans-Peter Hartung, Xavier Montalban, Bernard M J Uitdehaag, David G MacManus, Tarek A Yousry, Claudia A M Gandini Wheeler-Kingshott, Bingbing Li, Norman Putzki, Martin Merschhemke, Dieter A Häring, Jerry S Wolinsky
Objective: To investigate the relationship between brain volume and disability worsening over ≥3 years in the natural history of primary progressive multiple sclerosis using data from the placebo group of the INFORMS trial ( n  = 487; clinicaltrials.gov NCT00731692). Methods: Magnetic resonance imaging scans were collected annually. Brain volume loss was determined using SIENA. Patients were stratified by baseline normalized brain volume after adjusting for demographic and disease-burden covariates...
March 2018: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29550077/the-european-urology-residents-education-programme-hands-on-training-format-4-years-of-hands-on-training-improvements-from-the-european-school-of-urology
#17
Bhaskar K Somani, Ben Van Cleynenbreugel, Ali Gozen, Jaun Palou, Sas Barmoshe, Shekhar Biyani, Josep M Gaya, Giles Hellawell, Gio Pini, Faba R Oscar, Rafael Sanchez Salas, Petr Macek, Andreas Skolarikos, Christian Wagner, Viktor Eret, Stephen Haensel, Giampaolo Siena, Marek Schmidt, Max Klitsch, Stepan Vesely, Achilles Ploumidis, Silvia Proietti, Guido Kamphuis, Theodore Tokas, Rob Geraghty, Dominico Veneziano
BACKGROUND: The European School of Urology (ESU) started the European Urology Residents Education Programme (EUREP) in 2003 for final year urology residents, with hands-on training (HOT) added later in 2007. OBJECTIVE: To assess the geographical reach of EUREP, trainee demographics, and individual quality feedback in relation to annual methodology improvements in HOT. DESIGN, SETTING, AND PARTICIPANTS: From September 2014 to October 2017 (four EUREP courses) several new features have been applied to the HOT format of the EUREP course: 1:1 training sessions (2015), fixed 60-min time slots (2016), and standardised teaching methodology (2017)...
March 14, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29549466/within-patient-fluctuation-of-brain-volume-estimates-from-short-term-repeated-mri-measurements-using-siena-fsl
#18
Roland Opfer, Ann-Christin Ostwaldt, Christine Walker-Egger, Praveena Manogaran, Maria Pia Sormani, Nicola De Stefano, Sven Schippling
BACKGROUND: Measurements of brain volume loss (BVL) in individual patients are currently discussed controversially. One concern is the impact of short-term biological noise, like hydration status. METHODS: Three publicly available reliability MRI datasets with scan intervals of days to weeks were used. An additional cohort of 60 early relapsing multiple sclerosis (MS) patients with MRI follow-ups was analyzed to test whether after 1 year pathological BVL is detectable in a relevant fraction of MS patients...
May 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29535120/identification-of-calcium-pyrophosphate-deposition-disease-cppd-by-ultrasound-reliability-of-the-omeract-definitions-in-an-extended-set-of-joints-an-international-multiobserver-study-by-the-omeract-calcium-pyrophosphate-deposition-disease-ultrasound-subtask
#19
Georgios Filippou, Carlo Alberto Scirè, Antonella Adinolfi, Nemanja S Damjanov, Greta Carrara, George A W Bruyn, Tomas Cazenave, Maria Antonietta D'Agostino, Andrea Delle Sedie, Valentina Di Sabatino, Mario Enrique Diaz Cortes, Emilio Filippucci, Frederique Gandjbakhch, Marwin Gutierrez, Daryl K Maccarter, Mihaela Micu, Ingrid Möller Parera, Gaël Mouterde, Mohamed Atia Mortada, Esperanza Naredo, Carlos Pineda, Francesco Porta, Anthony M Reginato, Iulia Satulu, Wolfgang A Schmidt, Teodora Serban, Lene Terslev, Violeta Vlad, Florentin Ananu Vreju, Pascal Zufferey, Panagiotis Bozios, Carmela Toscano, Valentina Picerno, Annamaria Iagnocco
OBJECTIVES: To assess the reliability of the OMERACT ultrasound (US) definitions for the identification of calcium pyrophosphate deposition disease (CPPD) at the metacarpal-phalangeal, triangular fibrocartilage of the wrist (TFC), acromioclavicular (AC) and hip joints. METHODS: A web-based exercise and subsequent patient-based exercise were carried out. A panel of 30 OMERACT members, participated at the web-based exercise by evaluating twice a set of US images for the presence/absence of CPPD...
March 13, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29527505/establishing-pathological-cut-offs-for-lateral-ventricular-volume-expansion-rates
#20
Michael G Dwyer, Jesper Hagemeier, Niels Bergsland, Dana Horakova, Jonathan R Korn, Nasreen Khan, Tomas Uher, Jennie Medin, Diego Silva, Manuela Vaneckova, Eva Kubala Havrdova, Robert Zivadinov
Background: A percent brain volume change (PBVC) cut-off of -0.4% per year has been proposed to distinguish between pathological and physiological changes in multiple sclerosis (MS). Unfortunately, standardized PBVC measurement is not always feasible on scans acquired outside research studies or academic centers. Percent lateral ventricular volume change (PLVVC) is a strong surrogate measure of PBVC, and may be more feasible for atrophy assessment on real-world scans. However, the PLVVC rate corresponding to the established PBVC cut-off of -0...
2018: NeuroImage: Clinical
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