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https://www.readbyqxmd.com/read/28917411/accelerated-15%C3%A2-mw-pulsed-light-crosslinking-to-treat-progressive-keratoconus-two-year-clinical-results
#1
Cosimo Mazzotta, Stefano Baiocchi, Simone Alex Bagaglia, Mario Fruschelli, Alessandro Meduri, Miguel Rechichi
PURPOSE: To assess the clinical and microstructural results of accelerated 15 mW pulsed-light corneal crosslinking (CXL) to treat progressive keratoconus. SETTING: Siena Crosslinking Center, Siena, Italy. DESIGN: Prospective case series. METHODS: After epithelium removal (with Epi-Clear) and 10 minutes stromal soaking with riboflavin 0.1% hydroxypropyl methylcellulose solution, all eyes had 15 mW/cm(2) pulsed-light epithelium-off accelerated CXL for 6 minutes of ultraviolet-A (UVA) irradiation (1 second on/1 second off), maintaining a total UVA exposure of 12 minutes at a fluence of 5...
August 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28916408/robot-assisted-kidney-transplantation-the-european-experience
#2
Alberto Breda, Angelo Territo, Luis Gausa, Volkan Tuğcu, Antonio Alcaraz, Mireia Musquera, Karel Decaestecker, Liesbeth Desender, Michael Stockle, Martin Janssen, Paolo Fornara, Nasreldin Mohammed, Giampaolo Siena, Sergio Serni, Luis Guirado, Carma Facundo, Nicolas Doumerc
BACKGROUND: Robot-assisted kidney transplantation (RAKT) has recently been introduced to reduce the morbidity of open kidney transplantation (KT). OBJECTIVE: To evaluate perioperative and early postoperative RAKT outcomes. DESIGN, SETTING AND PARTICIPANTS: This was a multicenter prospective observational study of 120 patients who underwent RAKT, predominantly with a living donor kidney, in eight European institutions between July 2015 and May 2017, with minimum follow-up of 1 mo...
September 12, 2017: European Urology
https://www.readbyqxmd.com/read/28903424/identification-and-characterization-of-a-novel-scyl3-ntrk1-rearrangement-in-a-colorectal-cancer-patient
#3
Massimo Milione, Elena Ardini, Jason Christiansen, Emanuele Valtorta, Silvio Veronese, Roberta Bosotti, Alessio Pellegrinelli, Adele Testi, Filippo Pietrantonio, Giovanni Fucà, Ge Wei, Danielle Murphy, Salvatore Siena, Antonella Isacchi, Filippo De Braud
In colorectal cancer patients, chromosomal rearrangements involving NTRK1 gene (encoding the TRKA protein) are shown in a small subset of patients and are associated with the constitutive activation of the kinase domain of TRKA. In turn, activated TRKA-fusion proteins are associated with proliferation and survival in colorectal cancer tumors. Here we report the identification and functional characterization of a new SCYL3-NTRK1 fusion gene in a 61-year-old colorectal cancer patient. To our knowledge, this fusion protein has never been previously documented in oncological patients...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28867260/screening-for-adhd-in-adults-with-cystic-fibrosis-prevalence-health-related-quality-of-life-and-adherence
#4
Anna M Georgiopoulos, Deborah Friedman, Elizabeth A Porter, Amy Krasner, Sheetal P Kakarala, Breanna K Glaeser, Siena C Napoleon, Janet Wozniak
BACKGROUND: International guidelines recommend depression and anxiety screening in individuals with cystic fibrosis (CF), but Attention-Deficit Hyperactivity Disorder (ADHD) remains understudied. METHODS: Adults with CF (n=53) were screened using the Adult ADHD Self-Report Scale-v1.1 Symptom Checklist (ASRS-v1.1), Cystic Fibrosis Questionnaire-Revised (CFQ-R), and a self-report measure of treatment adherence. RESULTS: Elevated ADHD symptoms on the ASRS-v1...
August 31, 2017: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/28828394/teriflunomide-slows-bvl-in-relapsing-ms-a-reanalysis-of-the-temso-mri-data-set-using-siena
#5
Ernst-Wilhelm Radue, Till Sprenger, Laura Gaetano, Nicole Mueller-Lenke, Steve Cavalier, Karthinathan Thangavelu, Michael A Panzara, Jessica E Donaldson, Fiona M Woodward, Jens Wuerfel, Jerry S Wolinsky, Ludwig Kappos
OBJECTIVE: To assess, using structural image evaluation using normalization of atrophy (SIENA), the effect of teriflunomide, a once-daily oral immunomodulator, on brain volume loss (BVL) in patients with relapsing forms of MS enrolled in the phase 3 TEMSO study. METHODS: TEMSO MR scans were analyzed (study personnel masked to treatment allocation) using SIENA to assess brain volume changes between baseline and years 1 and 2 in patients treated with placebo or teriflunomide...
September 2017: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/28808286/source-and-dynamics-of-a-volcanic-caldera-unrest-campi-flegrei-1983-84
#6
Luca De Siena, Giovanni Chiodini, Giuseppe Vilardo, Edoardo Del Pezzo, Mario Castellano, Simona Colombelli, Nicola Tisato, Guido Ventura
Despite their importance for eruption forecasting the causes of seismic rupture processes during caldera unrest are still poorly reconstructed from seismic images. Seismic source locations and waveform attenuation analyses of earthquakes in the Campi Flegrei area (Southern Italy) during the 1983-1984 unrest have revealed a 4-4.5 km deep NW-SE striking aseismic zone of high attenuation offshore Pozzuoli. The lateral features and the principal axis of the attenuation anomaly correspond to the main source of ground uplift during the unrest...
August 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28794970/agreement-of-msmetrix-with-established-methods-for-measuring-cross-sectional-and-longitudinal-brain-atrophy
#7
Martijn D Steenwijk, Houshang Amiri, Menno M Schoonheim, Alexandra de Sitter, Frederik Barkhof, Petra J W Pouwels, Hugo Vrenken
INTRODUCTION: Despite the recognized importance of atrophy in multiple sclerosis (MS), methods for its quantification have been mostly restricted to the research domain. Recently, a CE labelled and FDA approved MS-specific atrophy quantification method, MSmetrix, has become commercially available. Here we perform a validation of MSmetrix against established methods in simulated and in vivo MRI data. METHODS: Whole-brain and gray matter (GM) volume were measured with the cross-sectional pipeline of MSmetrix and compared to the outcomes of FreeSurfer (cross-sectional pipeline), SIENAX and SPM...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28770031/systematic-left-ventricular-assist-device-implant-eligibility-with-non-invasive-assessment-the-siena-protocol
#8
REVIEW
Matteo Cameli, Ferdinando Loiacono, Stefania Sparla, Marco Solari, Elisabetta Iardino, Giulia Elena Mandoli, Sonia Bernazzali, Massimo Maccherini, Sergio Mondillo
In patients with end-stage left ventricular (LV) heart failure who receive LV assist device (LVAD) implantation, right ventricular (RV) failure represents a possible critical complication that heavily affects morbidity and mortality. Several clinical, laboratory, hemodynamic, and echocardiographic variables have been found to be associated with RV failure occurrence after surgery. Different models and risk scores have been proposed, with poor results. No accordance has ever been reached about RV pre-operative evaluation, and time has come to introduce a standardized systematic protocol for LVAD suitability assessment according to RV function...
June 2017: Journal of Cardiovascular Ultrasound
https://www.readbyqxmd.com/read/28767387/identification-and-characterization-of-a-novel-scyl3-ntrk1-rearrangement-in-a-colorectal-cancer-patient
#9
Massimo Milione, Elena Ardini, Jason Christiansen, Emanuele Valtorta, Silvio Veronese, Roberta Bosotti, Alessio Pellegrinelli, Adele Testi, Filippo Pietrantonio, Giovanni Fucà, Ge Wei, Danielle Murphy, Salvatore Siena, Antonella Isacchi, Filippo De Braud
In colorectal cancer patients, chromosomal rearrangements involving NTRK1 gene (encoding the TRKA protein) are shown in a small subset of patients and are associated with the constitutive activation of the kinase domain of TRKA. In turn, activated TRKA-fusion proteins are associated with proliferation and survival in colorectal cancer tumors.Here we report the identification and functional characterization of a new SCYL3-NTRK1 fusion gene in a 61-year-old colorectal cancer patient. To our knowledge, this fusion protein has never been previously documented in oncological patients...
July 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/28763227/strong-dependence-of-quantum-dot-delayed-luminescence-on-excitation-pulse-width
#10
Arianna Marchioro, Patrick J Whitham, Heidi D Nelson, Michael C De Siena, Kathryn E Knowles, Victor Z Polinger, Philip J Reid, Daniel R Gamelin
Delayed luminescence involving charge-carrier trapping and detrapping has recently been identified as a widespread and possibly universal phenomenon in colloidal quantum dots. Its near-power-law decay suggests a relationship with blinking. Here, using colloidal CuInS2 and CdSe quantum dots as model systems, we show that short (nanosecond) excitation pulses yield less delayed luminescence intensity and faster delayed luminescence decay than observed with long (millisecond) square-wave excitation pulses. Increasing the excitation power also affects the delayed luminescence intensity, but the delayed luminescence decay kinetics appear much less sensitive to excitation power than to excitation pulse width...
August 14, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28750510/a-selective-cation-exchange-strategy-for-the-synthesis-of-colloidal-yb-3-doped-chalcogenide-nanocrystals-with-strong-broadband-visible-absorption-and-long-lived-near-infrared-emission
#11
Sidney E Creutz, Rachel Fainblat, Younghwan Kim, Michael C De Siena, Daniel R Gamelin
Doping lanthanide ions into colloidal semiconductor nanocrystals is a promising strategy for combining their sharp and efficient 4f-4f emission with the strong broadband absorption and low-phonon-energy crystalline environment of semiconductors to make new solution-processable spectral-conversion nanophosphors, but synthesis of this class of materials has proven extraordinarily challenging because of fundamental chemical incompatibilities between lanthanides and most intermediate-gap semiconductors. Here, we present a new strategy for accessing lanthanide-doped visible-light-absorbing semiconductor nanocrystals by demonstrating selective cation exchange to convert precursor Yb(3+)-doped NaInS2 nanocrystals into Yb(3+)-doped PbIn2S4 nanocrystals...
August 16, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28730672/lipid-lowering-therapy-of-everolimus-related-severe-hypertriglyceridaemia-in-a-pancreatic-neuroendocrine-tumour-pnet
#12
V De Gennaro Colonna, C Pavanello, F Rusconi, A Sartore-Bianchi, S Siena, S Castelnuovo, C R Sirtori, G Mombelli
WHAT IS KNOWN AND OBJECTIVE: Hypertriglyceridaemia (HTG) is a potentially serious side effect of everolimus therapy. We here report a case of severe HTG in an everolimus-treated patient and provide recommendations for its management. CASE SUMMARY: The patient was a 70-year-old woman, being treated with everolimus for a pancreatic neuroendocrine tumour (pNET). She developed severe HTG to a maximum of 969 mg/dL after 22 months of therapy. Treatment with fenofibrate rapidly normalized triglyceride (TG) levels...
July 21, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28720485/ceftaroline-modulates-the-innate-immune-and-host-defense-responses-of-immunocompetent-cells-exposed-to-cigarette-smoke
#13
A Bruno, C Cipollina, S Di Vincenzo, L Siena, P Dino, F Di Gaudio, M Gjomarkaj, E Pace
BACKGROUND: Cigarette smoke, the principal risk factor for chronic obstructive pulmonary disease (COPD), negatively influences the effectiveness of the immune system's response to a pathogen. The antibiotic ceftaroline exerts immune-modulatory effects in bronchial epithelial cells exposed to cigarette smoke. AIMS AND METHODS: The present study aims to assess the effects of ceftaroline on TLR2 and TLR4 expression, LPS binding and TNF-α and human beta defensin (HBD2) release in an undifferentiated and PMA-differentiated human monocyte cell line (THP-1) exposed or not to cigarette smoke extracts (CSE)...
September 5, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28711308/the-impact-of-scopolamine-pretreatment-on-3-iodothyronamine-t1am-effects-on-memory-and-pain-in-mice
#14
Annunziatina Laurino, Ersilia Lucenteforte, Gaetano De Siena, Laura Raimondi
We previously demonstrated that 3-iodothyronamine (T1AM), a by-product of thyroid hormone metabolism, pharmacologically administered to mice acutely stimulated learning and memory acquisition and provided hyperalgesia with a mechanism which remains to be defined. We now aimed to investigate whether the T1AM effect on memory and pain was maintained in mice pre-treated with scopolamine, a non-selective muscarinic antagonist expected to induce amnesia and, possibly, hyperalgesia. Mice were pre-treated with scopolamine and, after 20min, injected intracerebroventricularly (i...
July 19, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28706852/neurological-software-tool-for-reliable-atrophy-measurement-neurostream-of-the-lateral-ventricles-on-clinical-quality-t2-flair-mri-scans-in-multiple-sclerosis
#15
Michael G Dwyer, Diego Silva, Niels Bergsland, Dana Horakova, Deepa Ramasamy, Jaqueline Durfee, Manuela Vaneckova, Eva Havrdova, Robert Zivadinov
BACKGROUND: There is a need for a brain volume measure applicable to the clinical routine scans. Nearly every multiple sclerosis (MS) protocol includes low-resolution 2D T2-FLAIR imaging. OBJECTIVES: To develop and validate cross-sectional and longitudinal brain atrophy measures on clinical-quality T2-FLAIR images in MS patients. METHODS: A real-world dataset from 109 MS patients from 62 MRI scanners was used to develop a lateral ventricular volume (LVV) algorithm with a longitudinal Jacobian-based extension, called NeuroSTREAM...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28669023/pooled-analysis-of-clinical-outcome-of-patients-with-chemorefractory-metastatic-colorectal-cancer-treated-within-phase-i-ii-clinical-studies-based-on-individual-biomarkers-of-susceptibility-a-single-institution-experience
#16
Andrea Sartore-Bianchi, Alessio Amatu, Erica Bonazzina, Stefano Stabile, Laura Giannetta, Giulio Cerea, Ilaria Schiavetto, Katia Bencardino, Chiara Funaioli, Riccardo Ricotta, Tiziana Cipani, Michele Schirru, Valentina Gambi, Laura Palmeri, Giulia Carlo-Stella, Francesca Rusconi, Sara Di Bella, Giovanni Burrafato, Andrea Cassingena, Emanuele Valtorta, Calogero Lauricella, Federica Pazzi, Alessandra Gambaro, Silvia Ghezzi, Giovanna Marrapese, Emiliana Tarenzi, Silvio Veronese, Mauro Truini, Angelo Vanzulli, Salvatore Siena
BACKGROUND: Patients with metastatic colorectal cancer (mCRC) refractory to standard therapies have a poor prognosis. In this setting, recruitment into clinical trials is warranted, and studies driven by selection according to individual tumor molecular characteristics are expected to provide added value. OBJECTIVE: We retrospectively analyzed data from patients with mCRC refractory to or following failure of standard therapies who were enrolled into phase I/II clinical studies at the Niguarda Cancer Center based on the presence of a specific molecular profile expected to represent the target of susceptibility to the experimental drug(s)...
August 2017: Targeted Oncology
https://www.readbyqxmd.com/read/28667256/clues-on-the-origin-of-post-2000-earthquakes-at-campi-flegrei-caldera-italy
#17
G Chiodini, J Selva, E Del Pezzo, D Marsan, L De Siena, L D'Auria, F Bianco, S Caliro, P De Martino, P Ricciolino, Z Petrillo
The inter-arrival times of the post 2000 seismicity at Campi Flegrei caldera are statistically distributed into different populations. The low inter-arrival times population represents swarm events, while the high inter-arrival times population marks background seismicity. Here, we show that the background seismicity is increasing at the same rate of (1) the ground uplift and (2) the concentration of the fumarolic gas specie more sensitive to temperature. The seismic temporal increase is strongly correlated with the results of recent simulations, modelling injection of magmatic fluids in the Campi Flegrei hydrothermal system...
June 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28619415/international-travelers-sociodemographic-health-and-travel-characteristics-an-italian-study
#18
Gianmarco Troiano, Astrid Mercone, Alessandra Bagnoli, Nicola Nante
BACKGROUND: Approximately the 8% of travelers requires medical care, with the diagnosis of a vaccine-preventable disease. The aim of our study was to analyze the socio-demographic, health and travel characteristics of the Italian international travelers. METHODS: We conducted a cross sectional study from January 2015 to June 2016, at the Travel Medicine Clinic of Siena, asking the doctor to interview patients who attended the Clinic, recording socio-demographic and travel information, malaria prophylaxis, vaccinations...
March 2017: Annals of Global Health
https://www.readbyqxmd.com/read/28560547/gender-differences-in-resistance-to-schooling-the-role-of-dynamic-peer-influence-and-selection-processes
#19
Sara Geven, Jan O Jonsson, Frank van Tubergen
Boys engage in notably higher levels of resistance to schooling than girls. While scholars argue that peer processes contribute to this gender gap, this claim has not been tested with longitudinal quantitative data. This study fills this lacuna by examining the role of dynamic peer-selection and influence processes in the gender gap in resistance to schooling (i.e., arguing with teachers, skipping class, not putting effort into school, receiving punishments at school, and coming late to class) with two-wave panel data...
May 30, 2017: Journal of Youth and Adolescence
https://www.readbyqxmd.com/read/28531185/thermal-stability-and-kinetic-constants-for-129-variants-of-a-family-1-glycoside-hydrolase-reveal-that-enzyme-activity-and-stability-can-be-separately-designed
#20
Dylan Alexander Carlin, Siena Hapig-Ward, Bill Wayne Chan, Natalie Damrau, Mary Riley, Ryan W Caster, Bowen Bethards, Justin B Siegel
Accurate modeling of enzyme activity and stability is an important goal of the protein engineering community. However, studies seeking to evaluate current progress are limited by small data sets of quantitative kinetic constants and thermal stability measurements. Here, we report quantitative measurements of soluble protein expression in E. coli, thermal stability, and Michaelis-Menten constants (kcat, KM, and kcat/KM) for 129 designed mutants of a glycoside hydrolase. Statistical analyses reveal that functional Tm is independent of kcat, KM, and kcat/KM in this system, illustrating that an individual mutation can modulate these functional parameters independently...
2017: PloS One
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