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https://www.readbyqxmd.com/read/27906440/supramicrosurgical-lymphatico-venular-anastomosis-lva-in-treating-lymphoedema-36-months-preliminary-report
#1
P Gennaro, G Gabriele, M Mihara, K Kikuchi, C Salini, I Aboh, F Cascino, G Chisci, C Ungari
OBJECTIVE: Lymphoedema of the extremities is a widespread pathological condition that mostly occurs as a complication of cancer resections, especially in women. Conventional therapy refers to conservative and physiotherapeutic approaches. Surgical strategies have been widely reported in the literature and are still challenging. Part of this literature focuses on the supra microsurgical lymphaticovenular anastomosis (LVA) technique. LVA is characterized by a high success rate, minimal invasivity and broad indications...
November 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27883019/17-oxo-dha-displays-additive-anti-inflammatory-effects-with-fluticasone-propionate-and-inhibits-the-nlrp3-inflammasome
#2
Chiara Cipollina, Serena Di Vincenzo, Liboria Siena, Caterina Di Sano, Mark Gjomarkaj, Elisabetta Pace
Chronic obstructive pulmonary disease (COPD) is characterized by reduced lung function associated with increased local and systemic inflammatory markers, such as TNFα and IL-1β. Glucocorticoids are used to treat this chronic disease, however their efficacy is low and new drugs are very much required. 17-oxo-DHA is a cyclooxygenase-2-dependent, electrophilic, α,β-unsaturated keto-derivative of docosahexaenoic acid with anti-inflammatory properties. We evaluated the action of 17-oxo-DHA alone or in combination with the steroid fluticasone propionate (FP) in peripheral blood mononuclear cells (PBMCs) from COPD patients and healthy individuals exposed to lipopolysaccharide...
November 24, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27870245/the-art-of-compiling-protein-binding-site-ensembles
#3
Stefan Bietz, Rainer Fährrolfes, Matthias Rarey
Structure-based drug design starts with the collection, preparation, and initial analysis of protein structures. With more than 115,000 structures publically available in the Protein Data Bank (PDB), fully automated processes reliably performing these important preprocessing steps are needed. Several tools are available for these tasks, however, most of them do not address the special needs of scientists interested in protein-ligand interactions. In this paper, we summarize our research activities towards an automated processing pipeline from raw PDB data towards ready-to-use protein binding site ensembles...
December 2016: Molecular Informatics
https://www.readbyqxmd.com/read/27869986/physical-exercise-for-late-life-depression-customizing-an-intervention-for-primary-care
#4
Stamatula Zanetidou, Martino Belvederi Murri, Marco Menchetti, Giulio Toni, Fabrizio Asioli, Luigi Bagnoli, Donato Zocchi, Matteo Siena, Barbara Assirelli, Claudia Luciano, Mattia Masotti, Carlo Spezia, Monica Magagnoli, Mirco Neri, Mario Amore, Klea D Bertakis
OBJECTIVES: To identify which individual- and context-related factors influence the translation into clinical practice of interventions based on physical exercise (PE) as an adjunct to antidepressants (AD) for the treatment of late-life major depression (LLMD). DESIGN: Secondary analysis of a randomized controlled trial. SETTING: Primary care with psychiatric consultation-liaison programs (PCLPs)-organizational protocols that regulate the clinical management of individuals with psychiatric disorders...
November 21, 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27865140/overcoming-dynamic-molecular-heterogeneity-in-metastatic-colorectal-cancer-multikinase-inhibition-with-regorafenib-and-the-case-of-rechallenge-with-anti-egfr
#5
REVIEW
Andrea Sartore-Bianchi, Salvatore Siena, Giuseppe Tonini, Alberto Bardelli, Daniele Santini
In metastatic colorectal cancer (mCRC), fluorouracil-based combination therapy with oxaliplatin or irinotecan is the mainstay of first-line treatment. Patient survival has been significantly improved with the introduction of monoclonal antibodies against VEGF (bevacizumab), VEGFR2 (ramucirumab) or EGFR (cetuximab or panitumumab) in first- and second-line therapies. However, all patients treated with chemotherapy and targeted therapies will eventually relapse, and recently the emergence of alterations in EGFR, RAS, BRAF, ERB-B2, MET and possibly in other genes has been shown to jeopardize response to EGFR blockade...
October 29, 2016: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/27843629/clonal-evolution-and-kras-met-coamplification-during-secondary-resistance-to-egfr-targeted-therapy-in-metastatic-colorectal-cancer
#6
Andrea Sartore-Bianchi, Emanuele Valtorta, Alessio Amatu, Silvio Veronese, Calogero Lauricella, Erica Bonazzina, Giulia Siravegna, Mauro Truini, Alberto Bardelli, Salvatore Siena
No abstract text is available yet for this article.
2016: ESMO Open
https://www.readbyqxmd.com/read/27843597/quality-of-life-during-first-line-folfox4%C3%A2-panitumumab-in-ras-wild-type-metastatic-colorectal-carcinoma-results-from-a-randomised-controlled-trial
#7
Salvatore Siena, Josep Tabernero, Gyorgy Bodoky, David Cunningham, Fernando Rivera, Paul Ruff, Jean Luc Canon, Reija Koukakis, Gaston Demonty, Guy Hechmati, Jean-Yves Douillard
INTRODUCTION: Metastatic colorectal cancer is rarely curable. Improving quality of life is therefore a key treatment goal. We report quality of life for patients with RAS wild-type metastatic colorectal cancer in the PRIME study. METHODS: A randomised phase 3 open-label study of first-line panitumumab+FOLFOX4 vs FOLFOX4 enrolled adults with untreated metastatic colorectal cancer and an Eastern Cooperative Oncology Group performance status of 0-2. This analysis includes patients with wild-type RAS tumours (n=505)...
2016: ESMO Open
https://www.readbyqxmd.com/read/27843590/ntrk-gene-fusions-as-novel-targets-of-cancer-therapy-across-multiple-tumour-types
#8
REVIEW
Alessio Amatu, Andrea Sartore-Bianchi, Salvatore Siena
The tropomyosin receptor kinase (Trk) receptor family comprises 3 transmembrane proteins referred to as Trk A, B and C (TrkA, TrkB and TrkC) receptors that are encoded by the NTRK1, NTRK2 and NTRK3 genes, respectively. These receptor tyrosine kinases are expressed in human neuronal tissue and play an essential role in the physiology of development and function of the nervous system through activation by neurotrophins. Gene fusions involving NTRK genes lead to transcription of chimeric Trk proteins with constitutively activated or overexpressed kinase function conferring oncogenic potential...
2016: ESMO Open
https://www.readbyqxmd.com/read/27806467/automatic-vending-machines-contamination-a-pilot-study
#9
Rosa Cardaci, Sandra Burgassi, Davide Golinelli, Nicola Nante, Mario A Battaglia, Daiana Bezzini, Gabriele Messina
Hot-drinks vending machines are disseminated worldwide and millions of drinks are served every day. Because of a small number of studies on hot-drinks related illnesses, the aim of this pilot study was to identify the presence and load of bacterial species, potentially harmful for consumers, within hot-drinks vending machines external critical surfaces. This preliminary cross sectional study was carried out in April 2015 at the University of Siena, Italy. Samples were taken from the critical surfaces of 4 hot-drinks vending machines (VM); the analyzed VM's critical surfaces were: Dispense Areas, Nozzles and Glass-Holders...
June 30, 2016: Global Journal of Health Science
https://www.readbyqxmd.com/read/27793092/in-silico-prediction-and-deep-dna-sequencing-validation-indicate-phase-variation-in-115-neisseria-meningitidis-genes
#10
Emilio Siena, Romina D'Aurizio, David Riley, Hervé Tettelin, Silvia Guidotti, Giulia Torricelli, E Richard Moxon, Duccio Medini
BACKGROUND: The Neisseria meningitidis (Nm) chromosome shows a high abundance of simple sequence DNA repeats (SSRs) that undergo stochastic, reversible mutations at high frequency. This mechanism is reflected in an extensive phenotypic diversity that facilitates Nm adaptation to dynamic environmental changes. To date, phase-variable phenotypes mediated by SSRs variation have been experimentally confirmed for 26 Nm genes. RESULTS: Here we present a population-scale comparative genomic analysis that identified 277 genes and classified them into 52 strong, 60 moderate and 165 weak candidates for phase variation...
October 28, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27793025/hedgehog-pathway-dysregulation-contributes-to-the-pathogenesis-of-human-gastrointestinal-stromal-tumors-via-gli-mediated-activation-of-kit-expression
#11
Chih-Min Tang, Tracy E Lee, Sabriya A Syed, Adam M Burgoyne, Stephanie Y Leonard, Fei Gao, Jonathan C Chan, Eileen Shi, Juliann Chmielecki, Deborah Morosini, Kai Wang, Jeffrey S Ross, Michael L Kendrick, Michael R Bardsley, Martina De Siena, Junhao Mao, Olivier Harismendy, Tamas Ordog, Jason K Sicklick
Gastrointestinal stromal tumors (GIST) arise within the interstitial cell of Cajal (ICC) lineage due to activating KIT/PDGFRA mutations. Both ICC and GIST possess primary cilia (PC), which coordinate PDGFRA and Hedgehog signaling, regulators of gastrointestinal mesenchymal development. Therefore, we hypothesized that Hedgehog signaling may be altered in human GIST and controls KIT expression. Quantitative RT-PCR, microarrays, and next generation sequencing were used to describe Hedgehog/PC-related genes in purified human ICC and GIST...
October 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27780717/high-sensitive-cardiac-troponin-t-hs-ctnt-assay-as-serum-biomarker-to-predict-cardiac-risk-in-myotonic-dystrophy-a-case-control-study
#12
Rea Valaperta, Maddalena Gaeta, Rosanna Cardani, Fortunata Lombardi, Benedetta Rampoldi, Claudia De Siena, Francesca Mori, Barbara Fossati, Paola Gaia, Ottavia Eleonora Ferraro, Simona Villani, Sara Iachettini, Marco Piccoli, Federica Cirillo, Enrico Pusineri, Giovanni Meola, Elena Costa
BACKGROUND: Myotonic dystrophy (DM) is a genetic disorder caused by nucleotide repeats expansion. Sudden death represents the main cause of mortality in DM patients. Here, we investigated the relationship between serum cardiac biomarkers with clinical parameters in DM patients. METHODS: Case-control study included 59 DM patients and 22 healthy controls. An additional group of 62 controls with similar cardiac defects to DM were enrolled. RESULTS: NT-proBNP, hs-cTnT and CK levels were significantly increased in DM patients compared to healthy subjects (p=0...
December 1, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/27766087/co-evolution-of-friendships-and-antipathies-a-longitudinal-study-of-preschool-peer-groups
#13
João R Daniel, António J Santos, Marta Antunes, Marília Fernandes, Brian E Vaughn
We used stochastic actor-based models to test whether the developmental dynamics of friendships and antipathies in preschool peer groups (followed throughout three school years) were co-dependent. We combined choices from three sociometric tasks of 142 children to identify friendship and antipathy ties and used SIENA to model network dynamics. Our results show that different social processes drive the development of friendship and antipathy ties, and that they do not develop in association (i.e., friendship ties are not dependent on existing antipathies, and vice-versa)...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27744504/the-effect-of-dimethyl-fumarate-on-cerebral-gray-matter-atrophy-in-multiple-sclerosis
#14
Sheena L Dupuy, Shahamat Tauhid, Shelley Hurwitz, Renxin Chu, Fawad Yousuf, Rohit Bakshi
INTRODUCTION: The objective of this pilot study was to compare cerebral gray matter (GM) atrophy over 1 year in patients starting dimethyl fumarate (DMF) for multiple sclerosis (MS) to that of patients on no disease-modifying treatment (noDMT). DMF is an established therapy for relapsing-remitting (RR) MS. METHODS: We retrospectively analyzed 20 patients with RRMS at the start of DMF [age (mean ± SD) 46.1 ± 10.2 years, Expanded Disability Status Scale (EDSS) score 1...
December 2016: Neurology and Therapy
https://www.readbyqxmd.com/read/27688965/short-term-mri-measurements-as-predictors-of-edss-progression-in-relapsing-remitting-multiple-sclerosis-grey-matter-atrophy-but-not-lesions-are-predictive-in-a-real-life-setting
#15
Johanna von Gumberz, Mina Mahmoudi, Kim Young, Sven Schippling, Roland Martin, Christoph Heesen, Susanne Siemonsen, Jan-Patrick Stellmann
BACKGROUND: Magnetic resonance imaging (MRI) is the best biomarker of inflammatory disease activity in relapsing remitting Multiple Sclerosis (RRMS) so far but the association with disability is weak. Appearance of new MRI-lesions is used to evaluate response to immunotherapies in individual patients as well as being the most common primary outcome in phase-2 trials. Measurements of brain atrophy show promising outcomes in natural cohort studies and some phase-2 trials. From a theoretical perspective they might represent irreversible neurodegeneration and be more closely associated with disability...
2016: PeerJ
https://www.readbyqxmd.com/read/27688944/reliable-measurements-of-brain-atrophy-in-individual-patients-with-multiple-sclerosis
#16
Dirk Smeets, Annemie Ribbens, Diana M Sima, Melissa Cambron, Dana Horakova, Saurabh Jain, Anke Maertens, Eline Van Vlierberghe, Vasilis Terzopoulos, Anne-Marie Van Binst, Manuela Vaneckova, Jan Krasensky, Tomas Uher, Zdenek Seidl, Jacques De Keyser, Guy Nagels, Johan De Mey, Eva Havrdova, Wim Van Hecke
INTRODUCTION: As neurodegeneration is recognized as a major contributor to disability in multiple sclerosis (MS), brain atrophy quantification could have a high added value in clinical practice to assess treatment efficacy and disease progression, provided that it has a sufficiently low measurement error to draw meaningful conclusions for an individual patient. METHOD: In this paper, we present an automated longitudinal method based on Jacobian integration for measuring whole-brain and gray matter atrophy based on anatomical magnetic resonance images (MRI), named MSmetrix...
September 2016: Brain and Behavior
https://www.readbyqxmd.com/read/27672986/poster-227-cauda-equina-syndrome-after-lumbar-disk-herniation-a-case-report
#17
Siena N Ona, Raymund V Millan
No abstract text is available yet for this article.
September 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/27672915/poster-149-diagnosis-of-an-ulnar-nerve-foreign-body-by-ultrasound-a-case-report
#18
Siena N Ona, John Norbury, Clinton E Faulk
No abstract text is available yet for this article.
September 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/27647228/posttransplant-solid-organ-malignancies-in-lung-transplant-recipients-a-single-center-experience-and-review-of-the-literature
#19
David Bennett, Antonella Fossi, Rosa Metella Refini, Francesco Gentili, Luca Luzzi, Luca Voltolini, Piero Paladini, Maria Antonietta Mazzei, Paola Rottoli
PURPOSE: Solid-organ tumor incidences are higher in solid organ transplant patients than in the general population. The aim of this study was to analyze solid-organ tumor frequency and characteristics in a population of lung transplant patients and provide a brief review of the literature. METHODS: A retrospective analysis was conducted of all patients who underwent a lung transplant in the Lung Transplant Program at the University Hospital of Siena, Italy, from 2001 to 2014 (n = 119)...
August 23, 2016: Tumori
https://www.readbyqxmd.com/read/27619513/-cancer-bio-immunotherapy-in-siena-thirteenth-meeting-of-the-network-italiano-per-la-bioterapia-dei-tumori-nibit-siena-italy-october-8-10-2015
#20
Michele Maio, Erica Bertocci, Carolina Fazio, Carla Chiarucci, Ornella Cutaia, Elisa Scala, Gianluca Giacobini, Maria Fortunata Lofiego, Ester Fonsatti, Cristina Maccalli, Hugues J M G Nicolay, Giorgio Parmiani
No abstract text is available yet for this article.
September 12, 2016: Cancer Immunology, Immunotherapy: CII
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