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JOURNAL ARTICLE
Laurie Fraticelli, Elise Verot, Hans-Martin Späth, Marine C Genton, Cédric Kempf, Celine Clement, Adeline Darlington-Bernard, Sylvain Roy, Claude Dussart, Gérard Mick, Florence Carrouel
INTRODUCTION: The healthcare pathway is at the heart of public health organization concerns, but communication between the various players can be an obstacle. This work, produced by a French transdisciplinary team, offers a methodological approach based on formalized consensus to elaborate a glossary of healthcare pathways. A two-steps procedure was elaborated, including a double rounded Delphi method to formalize expert consensus, and two groups of experts: a workgroup and a review group...
2024: Frontiers in Public Health
#22
JOURNAL ARTICLE
Elena Harran, Grégoire Kuntz, Anouk Decors, Pascale Bourhy, Alexandre Auffret, Clément Bigeard, Damien Cherel, Angeli Kodjo, Eric Le Dréan, Cyrille Lejas, Guillaume Lequeux, Marie-Agnès Pilard, Mathilde Pivette, Yvonnick Guillois, Florence Ayral
Pathogenic Leptospira can cause leptospirosis: a widespread, potentially fatal bacterial zoonosis whose risk is mediated by the soil and water features, animal host distributions, meaning the local ecosystem. When human cases of leptospirosis occur, it is challenging to track down their source because ecosystem-level epidemiological knowledge on Leptospira is needed. Between 2016 and 2019 in a focal riparian ecosystem, the human population experienced an outbreak and successive cases of leptospirosis attributable to L...
June 2024: One Health
#23
REVIEW
Alexandre Salaun, Emmanuel de Maistre, Marlène Daller, Chan Sombrun, Frédéric Chagué, Florence Bichat, Luc Rochette, Nicolas Danchin, Laurent Fauchier, Marianne Zeller, Yves Cottin
Around 10% of patients with acute coronary syndrome are treated by vitamin K antagonists or non-vitamin K antagonist oral anticoagulants for various indications. The initial management of these patients is highly complex, and new guidelines specify that, only during percutaneous coronary intervention, a bolus of unfractionated heparin is recommended in one of the following circumstances: (1) if the patient is receiving a non-vitamin K antagonist oral anticoagulant; or (2) if the international normalized ratio is<2...
April 12, 2024: Archives of Cardiovascular Diseases
#24
JOURNAL ARTICLE
Saverio Caini, Melania Assedi, Benedetta Bendinelli, Ilaria Ermini, Luigi Facchini, Miriam Fontana, Davide Liedl, Domenico Palli, Elisa Pastore, Andrea Querci, Calogero Saieva, Giovanna Masala
OBJECTIVES, SETTING AND PARTICIPANTS: We aimed to examine changes in dietary habits, lifestyles (e.g., smoking, physical activity levels, and alcohol intake), anthropometry, other individual health-relevant characteristics, and overall adherence to 2018 WCRF/AICR cancer prevention recommendations, among women enrolled in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Florence cohort. DESIGN AND MEASUREMENTS: We fitted age- and energy intake-adjusted generalized linear models to describe (a) changes occurring over a person's lifetime in the transition from adulthood to older age, and (b) differences between women aged 56-60 years belonging to two birth cohorts spaced apart by around 25 years (born in 1933-1941 vs...
April 20, 2024: Journal of Nutrition, Health & Aging
#25
JOURNAL ARTICLE
Manon Baudic, Hiroshige Murata, Fernanda M Bosada, Uirá Souto Melo, Takanori Aizawa, Pierre Lindenbaum, Lieve E van der Maarel, Amaury Guedon, Estelle Baron, Enora Fremy, Adrien Foucal, Taisuke Ishikawa, Hiroya Ushinohama, Sean J Jurgens, Seung Hoan Choi, Florence Kyndt, Solena Le Scouarnec, Vincent Wakker, Aurélie Thollet, Annabelle Rajalu, Tadashi Takaki, Seiko Ohno, Wataru Shimizu, Minoru Horie, Takeshi Kimura, Patrick T Ellinor, Florence Petit, Yves Dulac, Paul Bru, Anne Boland, Jean-François Deleuze, Richard Redon, Hervé Le Marec, Thierry Le Tourneau, Jean-Baptiste Gourraud, Yoshinori Yoshida, Naomasa Makita, Claude Vieyres, Takeru Makiyama, Stephan Mundlos, Vincent M Christoffels, Vincent Probst, Jean-Jacques Schott, Julien Barc
While 3D chromatin organization in topologically associating domains (TADs) and loops mediating regulatory element-promoter interactions is crucial for tissue-specific gene regulation, the extent of their involvement in human Mendelian disease is largely unknown. Here, we identify 7 families presenting a new cardiac entity associated with a heterozygous deletion of 2 CTCF binding sites on 4q25, inducing TAD fusion and chromatin conformation remodeling. The CTCF binding sites are located in a gene desert at 1 Mb from the Paired-like homeodomain transcription factor 2 gene (PITX2)...
April 20, 2024: Nature Communications
#26
JOURNAL ARTICLE
Florence Blanchard, Anne Bruneau, Etienne Laliberté
PREMISE: Spectroscopy is a powerful remote sensing tool for monitoring plant biodiversity over broad geographic areas. Increasing evidence suggests that foliar spectral reflectance can be used to identify trees at the species level. However, most studies have focused on only a limited number of species at a time, and few studies have explored the underlying phylogenetic structure of leaf spectra. Accurate species identifications are important for reliable estimations of biodiversity from spectral data...
April 20, 2024: American Journal of Botany
#27
JOURNAL ARTICLE
James Zhang, Florence Bradshaw, Michal Duchniewicz, Fernanda W Fernandes, Rahul Geetala, Matjia Krkovic
Introduction Understanding the different opioid pain relief requirements between patients with upper limb fractures can be useful in forming specific evidence-based guidelines and balancing patient-clinician prescribing discussions with opioid stewardship. We investigated the predictors for opioid requirements in upper limb fractures. Methods We retrospectively investigated all upper limb fractures from the shoulder to the wrist treated at a major trauma center from January 2015 to January 2022. The data collected consisted of fracture location, demographics, comorbidities, and management options...
March 2024: Curēus
#28
Agathe Hovine, Céline Chauleur, Christophe Gauld, Florence Rancon, Jean-Christophe Gris, Brigitte Tardy, Antoine Giraud, Tiphaine Raia-Barjat
[This corrects the article DOI: 10.3389/fcell.2023.1115622.].
2024: Frontiers in Cell and Developmental Biology
#29
JOURNAL ARTICLE
François Bertucci, Florence Lerebours, Michele Ceccarelli, Arnaud Guille, Najeeb Syed, Pascal Finetti, José Adélaïde, Steven Van Laere, Anthony Goncalves, Patrice Viens, Daniel Birnbaum, Emilie Mamessier, Céline Callens, Davide Bedognetti
BACKGROUND: Inflammatory breast cancer (IBC) is the most pro-metastatic form of BC. Better understanding of its enigmatic pathophysiology is crucial. We report here the largest whole-exome sequencing (WES) study of clinical IBC samples. METHODS: We retrospectively applied WES to 54 untreated IBC primary tumor samples and matched normal DNA. The comparator samples were 102 stage-matched non-IBC samples from TCGA. We compared the somatic mutational profiles, spectra and signatures, copy number alterations (CNAs), HRD and heterogeneity scores, and frequencies of actionable genomic alterations (AGAs) between IBCs and non-IBCs...
April 18, 2024: Journal of Translational Medicine
#30
JOURNAL ARTICLE
Marcos Gil-Garcia, Ana I Benítez-Mateos, Marcell Papp, Florence Stoffel, Chiara Morelli, Karl Normak, Katarzyna Makasewicz, Lenka Faltova, Francesca Paradisi, Paolo Arosio
The mechanisms that underlie the regulation of enzymatic reactions by biomolecular condensates and how they scale with compartment size remain poorly understood. Here we use intrinsically disordered domains as building blocks to generate programmable enzymatic condensates of NADH-oxidase (NOX) with different sizes spanning from nanometers to microns. These disordered domains, derived from three distinct RNA-binding proteins, each possessing different net charge, result in the formation of condensates characterized by a comparable high local concentration of the enzyme yet within distinct environments...
April 18, 2024: Nature Communications
#31
JOURNAL ARTICLE
Romain Melich, Patricia Emmel, Alexis Vivien, Florence Sechaud, Carole Mandaroux, Sofiene Mhedhbi, Philippe Bussat, Isabelle Tardy, Samir Cherkaoui
OBJECTIVE: Phase-shift contrast agents consist of a liquid perfluorocarbon core that can be vaporized by ultrasound to generate echogenic contrast with excellent spatiotemporal control. The purpose of the present work was to evaluate the in vitro and in vivo behavior of condensed lipid-shelled nanodroplets (NDs) using different analytical procedures. METHODS: Perfluorobutane NDs were prepared by condensation of precursor fluorescently labeled lipid-shelled microbubbles (MBs) and were characterized in terms of size distribution, gas core content and in vitro stability in blood, as well as for their acoustic vaporization behavior using a custom-made setup...
April 17, 2024: Ultrasound in Medicine & Biology
#32
JOURNAL ARTICLE
Kévin Hebert, Lore Santoro, Maeva Monnier, Florence Castan, Ikrame Berkane, Eric Assénat, Cyril Fersing, Pauline Gélibert, Jean-Pierre Pouget, Manuel Bardiès, Pierre-Olivier Kotzki, Emmanuel Deshayes
[177 Lu]Lu-DOTATATE has been approved for progressive and inoperable gastroenteropancreatic neuroendocrine tumors (GEP-NETs) that overexpress somatostatin receptors. The absorbed doses by limiting organs and tumors can be quantified by serial postinfusion scintigraphy measurements of the γ-emissions from 177 Lu. The objective of this work was to explore how postinfusion [177 Lu]Lu-DOTATATE dosimetry could influence clinical management by predicting treatment efficacy (tumor shrinkage and survival) and toxicity...
April 18, 2024: Journal of Nuclear Medicine
#33
JOURNAL ARTICLE
Helene Yager, Manon Tauzin, Xavier Durrmeyer, Darina Todorova, Laurent Storme, Thierry Debillon, Florence Casagrande, Camille Jung, Etienne Audureau, Richard Layese, Laurence Caeymaex
OBJECTIVE: To compare reintubation rates after planned extubation and unplanned extubation (UE) in patients in neonatal intensive care units (NICUs), to analyse risk factors for reintubation after UE and to compare outcomes in patients with and without UE. DESIGN: Prospective, observational study nested in a randomised controlled trial (SEPREVEN/Study on Epidemiology and PRevention of adverse EVEnts in Neonates). Outcomes were expected to be independent of the intervention tested...
April 18, 2024: Archives of Disease in Childhood. Fetal and Neonatal Edition
#34
JOURNAL ARTICLE
Arnaud Fernandez, Florence Askenazy, Radia Zeghari, Philippe Auby, Philippe Robert, Susanne Thümmler, Morgane Gindt
IMPORTANCE: Somatic symptoms are a major concern among the pediatric population because of frequency and burden. The association between adverse childhood experiences and somatic symptoms in adults is well established but less is known concerning somatic symptoms in young people. OBJECTIVE: To explore the frequency and intensity of somatic symptoms in children and adolescents exposed to traumatic events. DESIGN, SETTING, AND PARTICIPANTS: This cross-sectional study was conducted from January 1 to December 31, 2021, at the Nice Pediatric Psychotrauma Referral Center in Nice, France...
April 1, 2024: JAMA Network Open
#35
JOURNAL ARTICLE
Sibel Nayman, Isabelle Florence Schricker, Iris Reinhard, Janina Kim Dreer, Annika Sophie Richter, Christine Kuehner
Premenstrual dysphoric disorder (PMDD) is characterized by a cyclical symptom course. Previous research provides limited findings on possible menstrual-cycle-related psychological and psychoendocrinological processes in PMDD. By using ambulatory assessment (AA), we aimed to compare mood and cortisol cyclicity in individuals with PMDD and healthy controls (HC), and to assess effects of habitual and momentary repetitive negative thinking (RNT) and present moment awareness (PMA) on mood and cortisol across the cycle in both groups...
April 18, 2024: J Psychopathol Clin Sci
#36
JOURNAL ARTICLE
Stella Kepha, Humphrey D Mazigo, Maurice R Odiere, Carlos Mcharo, Th'uva Safari, Paul M Gichuki, Wykcliff Omondi, Florence Wakesho, Alejandro Krolewiecki, Rachel L Pullan, Charles S Mwandawiro, William E Oswald, Katherine E Halliday
OBJECTIVES: Kenya has implemented a national school-based deworming program, which has led to substantial decline in the prevalence of soil-transmitted helminths (STHs), although some pockets of infections remain. To effectively design an STH control program that leads to significant reductions of Trichuris trichiura, there is a need to understand the drivers of persistent infection despite ongoing treatment programs. METHODS: This study was conducted between July and September 2019 at the south coast of Kenya, using a two-stage sampling design...
June 2024: IJID Reg
#37
JOURNAL ARTICLE
Maïa Simon, Aurélie Bocquier, Ouarda Pereira, Alexandre Charmillon, Damien Gonthier, Florence Lieutier Colas, Camille Vallance, Adeline Welter, Céline Pulcini, Nathalie Thilly
BACKGROUND: GPs are responsible for more than 70% of outpatient antibiotic prescriptions in France. Metrics are important antibiotic stewardship tools that can be used to set targets for improvement and to give feedback to professionals and stakeholders. OBJECTIVES: The primary objective of the present study was to select a set of proxy indicators (PIs) based on 10 previously developed PIs, to estimate the appropriateness of antibiotic prescriptions by GPs. The secondary objective was to evaluate the clinimetric properties of the selected PIs...
April 2024: JAC-antimicrobial resistance
#38
JOURNAL ARTICLE
Faustina Adoboi, Aliu Mohammed, Precious Adade Duodu, Richard Gyan Aboagye, Abdul-Aziz Seidu, Florence Gyembuzie Wongnaah, Bright Opoku Ahinkorah
BACKGROUND: Suicide represents a major public health concern, affecting a significant portion of individuals. However, there remains a gap in understanding the age and sex disparities in the occurrence of suicide. Therefore, this study aimed to investigate the sex-related inequalities in suicide rates in Ghana from 2000 to 2019. METHODS: We utilized data from the WHO Health Equity Assessment Toolkit (HEAT) online software. We analysed sex differences in both crude and age-standardized suicide rates in Ghana spanning from 2000 to 2019...
April 17, 2024: BMC Public Health
#39
JOURNAL ARTICLE
Tristan Kistler, Evert W Brascamp, Benjamin Basso, Piter Bijma, Florence Phocas
BACKGROUND: Breeding queens may be mated with drones that are produced by a single drone-producing queen (DPQ), or a group of sister-DPQs, but often only the dam of the DPQ(s) is reported in the pedigree. Furthermore, datasets may include colony phenotypes from DPQs that were open-mated at different locations, and thus to a heterogeneous drone population. METHODS: Simulation was used to investigate the impact of the mating strategy and its modelling on the estimates of genetic parameters and genetic trends when the DPQs are treated in different ways in the statistical evaluation model...
April 17, 2024: Genetics, Selection, Evolution: GSE
#40
JOURNAL ARTICLE
Ceri Evans, Kuda Mutasa, Sandra Rukobo, Margaret Govha, Patience Mushayanembwa, Bernard Chasekwa, Florence D Majo, Naume V Tavengwa, Jonathan Broad, Christie Noble, Ethan K Gough, Paul Kelly, Claire D Bourke, Jean H Humphrey, Robert Ntozini, Andrew J Prendergast
Children who are HIV-exposed but uninfected have increased infectious mortality compared to HIV-unexposed children, raising the possibility of immune abnormalities following exposure to maternal viraemia, immune dysfunction, and co-infections during pregnancy. In a secondary analysis of the SHINE trial in rural Zimbabwe we explored biological pathways underlying infant mortality, and maternal factors shaping immune development in HIV-exposed uninfected infants. Maternal inflammation and cytomegalovirus viraemia were independently associated with infant deaths: mortality doubled for each log10 rise in maternal C-reactive protein (adjusted hazard ratio (aHR) 2...
April 17, 2024: Nature Communications
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