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https://www.readbyqxmd.com/read/27915004/economic-analysis-of-the-nairobi-cancer-registry-implications-for-expanding-and-enhancing-cancer-registration-in-kenya
#1
Anne Korir, Robai Gakunga, Sujha Subramanian, Nathan Okerosi, Gladys Chesumbai, Patrick Edwards, Florence Tangka, Rachael Joseph, Nathan Buziba, Victor Rono, Donald Maxwell Parkin, Mona Saraiya
INTRODUCTION: Cancer registration is an important activity for informing cancer control activities. Cancer registries in Sub-Saharan Africa have limited resources to effectively operate because of competing priorities. To date, there has not been an assessment of the resources and funding needed to perform all the activities essential for cancer registration in Kenya. Evidence will help registries to quantify and advocate for the funds needed to sustain, enhance, and expand high quality cancer registration in Kenya...
November 30, 2016: Cancer Epidemiology
https://www.readbyqxmd.com/read/27914243/efficacy-and-safety-of-bevacizumab-containing-neoadjuvant-therapy-followed-by-interval-debulking-surgery-in-advanced-ovarian-cancer-results-from-the-anthalya-trial
#2
Roman Rouzier, Sébastien Gouy, Frédéric Selle, Eric Lambaudie, Anne Floquet, Virginie Fourchotte, Christophe Pomel, Pierre-Emmanuel Colombo, Elsa Kalbacher, Sandrine Martin-Francoise, Raffaele Fauvet, Philippe Follana, Anne Lesoin, Fabrice Lecuru, Youssef Ghazi, Julien Dupin, Elisabeth Chereau, Sarah Zohar, Paul Cottu, Florence Joly
AIM: To investigate whether adding bevacizumab to neoadjuvant carboplatin-paclitaxel (CP) helps achieve optimal debulking, measured by complete resection rate (CRR) at interval debulking surgery (IDS), in patients with initially unresectable International Federation of Gynecology and Obstetrics stage IIIC/IV ovarian, tubal or peritoneal adenocarcinoma. METHODS: Multicentre, open-label, non-comparative phase II study. Ninety-five patients randomised (2:1) to receive four cycles of neoadjuvant CP ±3 concomitant cycles of bevacizumab 15 mg/kg (BCP) followed by IDS...
November 30, 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27913153/changing-the-face-of-modern-medicine-stem-cells-gene-therapy-october-18-21-2016-florence-italy
#3
Daniel W Stuckey
No abstract text is available yet for this article.
November 25, 2016: EBioMedicine
https://www.readbyqxmd.com/read/27911894/head-lice-of-pygmies-reveal-the-presence-of-relapsing-fever-borreliae-in-the-republic-of-congo
#4
Nadia Amanzougaghene, Jean Akiana, Géor Mongo Ndombe, Bernard Davoust, Nardiouf Sjelin Nsana, Henri-Joseph Parra, Florence Fenollar, Didier Raoult, Oleg Mediannikov
BACKGROUND: Head lice, Pediculus humanus capitis, occur in four divergent mitochondrial clades (A, B, C and D), each having particular geographical distributions. Recent studies suggest that head lice, as is the case of body lice, can act as a vector for louse-borne diseases. Therefore, understanding the genetic diversity of lice worldwide is of critical importance to our understanding of the risk of louse-borne diseases. METHODOLOGY/PRINCIPAL FINDINGS: Here, we report the results of the first molecular screening of pygmies' head lice in the Republic of Congo for seven pathogens and an analysis of lice mitochondrial clades...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27909957/adaptive-radiation-therapy-in-head-and-neck-cancer-for-clinical-practice-state-of-the-art-and-practical-challenges
#5
REVIEW
Ovidiu Veresezan, Idriss Troussier, Alexis Lacout, Sarah Kreps, Sophie Maillard, Aude Toulemonde, Pierre-Yves Marcy, Florence Huguet, Juliette Thariat
Modern radiation therapy techniques are characterized by high conformality to tumor volumes and steep dose gradients to spare normal organs. These techniques require accurate clinical target volume definitions and rigorous assessment of set up uncertainties using image guidance, a concept called image-guided radiation therapy. Due to alteration of patient anatomy, changes in tissue density/volumes and tumor shrinkage over the course of treatment, treatment accuracy may be challenged. This may result in excessive irradiation of organs at risk/healthy tissues and undercoverage of target volumes with a significant risk of locoregional failure...
December 1, 2016: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/27908799/isolation-of-novel-stilbenoids-from-the-roots-of-cyrtopodium-paniculatum-orchidaceae
#6
Florence Auberon, Opeyemi Joshua Olatunji, Diamondra Raminoson, Christian D Muller, Beatriz Soengas, Frédéric Bonté, Annelise Lobstein
Four new stilbenoids, named cyrtopodinone (1), cyrtopodinol (2), and coeludols A and B (3-4) were isolated from the roots of Cyrtopodium paniculatum, together with 21 known stilbenoids derivatives (5-25). Their structures were elucidated by comprehensive spectroscopic analysis including extensive 1D and 2D-NMR techniques. The cytotoxic activities of the isolated compounds were tested on human glioblastoma U-87MG cell line with fluorescence-based image cytometry. Only four compounds (18, 19, 22 and 25) displayed moderate cytotoxicity with IC50 values of 45...
November 28, 2016: Fitoterapia
https://www.readbyqxmd.com/read/27908541/-mysterious-gingival-ulcers
#7
Elsa Poullot, Solène-Florence Kammerer, Claire Lamaison, Patrick Tas, Bénédicte Gilliot, Francisco Llamas Gutierrez
No abstract text is available yet for this article.
November 28, 2016: Annales de Pathologie
https://www.readbyqxmd.com/read/27906961/tracking-insecticide-resistance-in-mosquito-vectors-of-arboviruses-the-worldwide-insecticide-resistance-network-win
#8
Vincent Corbel, Nicole L Achee, Fabrice Chandre, Mamadou B Coulibaly, Isabelle Dusfour, Dina M Fonseca, John Grieco, Waraporn Juntarajumnong, Audrey Lenhart, Ademir J Martins, Catherine Moyes, Lee Ching Ng, João Pinto, Kamaraju Raghavendra, Hassan Vatandoost, John Vontas, David Weetman, Florence Fouque, Raman Velayudhan, Jean-Philippe David
No abstract text is available yet for this article.
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27906199/microduplication-of-the-arid1a-gene-causes-intellectual-disability-with-recognizable-syndromic-features
#9
Marie Bidart, Michèle El Atifi, Sarra Miladi, John Rendu, Véronique Satre, Pierre F Ray, Caroline Bosson, Françoise Devillard, Daphné Lehalle, Valérie Malan, Jeanne Amiel, Maria Antonietta Mencarelli, Margherita Baldassarri, Alessandra Renieri, Jill Clayton-Smith, Gaëlle Vieville, Julien Thevenon, Florence Amblard, François Berger, Pierre-Simon Jouk, Charles Coutton
PURPOSE: To determine whether duplication of the ARID1A gene is responsible for a new recognizable syndrome. METHODS: We describe four patients with a 1p36.11 microduplication involving ARID1A as identified by array-comparative genomic hybridization . We performed comparative transcriptomic analysis of patient-derived fibroblasts using RNA sequencing and evaluated the impact of ARID1A duplication on the cell cycle using fluorescence-activated cell sorting. Functional relationships between differentially expressed genes were investigated with ingenuity pathway analysis (IPA)...
December 1, 2016: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/27905407/endothelin-3-stimulates-cell-adhesion-and-cooperates-with-%C3%AE-1-integrins-during-enteric-nervous-system-ontogenesis
#10
Elodie Gazquez, Yuli Watanabe, Florence Broders-Bondon, Perrine Paul-Gilloteaux, Julie Heysch, Viviane Baral, Nadège Bondurand, Sylvie Dufour
Endothelin-3 (EDN3) and β1-integrins are required for the colonization of the embryonic gut by enteric neural crest cells (ENCCs) to form the enteric nervous system (ENS). β1-integrin-null ENCCs exhibit migratory defects in a region of the gut enriched in EDN3 and in specific extracellular matrix (ECM) proteins. We investigated the putative role of EDN3 on ENCC adhesion properties and its functional interaction with β1-integrins during ENS development. We show that EDN3 stimulates ENCC adhesion to various ECM components in vitro...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27905127/reply-letter-to-adcy5-related-dyskinesia-comments-on-characteristic-manifestations-and-variant-associated-severity
#11
Victor S C Fung, Florence C F Chang, Ana Westenberger, Christine Klein
No abstract text is available yet for this article.
December 1, 2016: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/27903461/clinical-characteristics-and-outcome-of-respiratory-syncytial-virus-infection-among-adults-hospitalized-with-influenza-like-illness-in-france
#12
Paul Loubet, Nezha Lenzi, Martine Valette, Vincent Foulongne, Anne Krivine, Nadhira Houhou, Gisele Lagathu, Sylvie Rogez, Sophie Alain, Xavier Duval, Florence Galtier, Deborah Postil, Pierre Tattevin, Philippe Vanhems, Fabrice Carrat, Bruno Lina, Odile Launay
OBJECTIVES: The aim of this study was to analyze characteristics and outcome of RSV infection in adults hospitalized with influenza-like illness (ILI). METHODS: Patients hospitalized with ILI were included in this prospective, multicenter study carried out in six French hospitals during three consecutive influenza seasons (2012-2015). RSV and other respiratory viruses were detected by multiplex PCR in nasopharyngeal swabs. Risk factors for RSV infection were identified by backward stepwise logistic regression analysis...
November 26, 2016: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/27903305/priorities-and-needs-for-research-on-urban-interventions-targeting-vector-borne-diseases-rapid-review-of-scoping-and-systematic-reviews
#13
EDITORIAL
Clara Bermudez-Tamayo, Olive Mukamana, Mabel Carabali, Lyda Osorio, Florence Fournet, Kounbobr Roch Dabiré, Celina Turchi Marteli, Adolfo Contreras, Valéry Ridde
This paper highlights the critical importance of evidence on vector-borne diseases (VBD) prevention and control interventions in urban settings when assessing current and future needs, with a view to setting policy priorities that promote inclusive and equitable urban health services. Research should produce knowledge about policies and interventions that are intended to control and prevent VBDs at the population level and to reduce inequities. Such interventions include policy, program, and resource distribution approaches that address the social determinants of health and exert influence at organizational and system levels...
December 1, 2016: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/27903240/central-line-associated-bloodstream-infections-in-a-tertiary-care-children-s-university-hospital-a-prospective-study
#14
Elisabetta Venturini, Carlotta Montagnani, Alessandra Benni, Sabrina Becciani, Klaus Peter Biermann, Salvatore De Masi, Elena Chiappini, Maurizio de Martino, Luisa Galli
BACKGROUND: The central-line associated bloodstream infections (CLABSI) are the most common healthcare-associated infections in childhood. Despite the international data available on healthcare-associated infections in selected groups of patients, there is a lack of large and good quality studies. The present survey is the first prospective study monitoring for 6 months the occurrence of central-line associated bloodstream infections in all departments of an Italian tertiary care children's university hospital...
December 1, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27902890/sexual-behavior-and-sexually-transmitted-infections-among-swingers-results-from-an-online-survey-in-belgium
#15
Tom Platteau, Jacques van Lankveld, Lieselot Ooms, Eric Florence
Swingers are couples practicing consensual extradyadic heterosexual relations. This subculture is defined by venues, and online communities. This study aimed to assess swingers' lifestyle, sexual health, history of testing for sexually transmitted infections (STI), and review risk factors for sexual risk behavior and STI transmission. An online survey was distributed through venues, chat- and dating websites. Most of 480 swingers starting the survey completed it (n = 392, 81.6%). Women (n = 146) reported more frequent swinging (p = 0...
November 30, 2016: Journal of Sex & Marital Therapy
https://www.readbyqxmd.com/read/27900502/values-and-preferences-on-the-use-of-oral-pre-exposure-prophylaxis-prep-for-hiv-prevention-among-multiple-populations-a-systematic-review-of-the-literature
#16
Florence M Koechlin, Virginia A Fonner, Sarah L Dalglish, Kevin R O'Reilly, Rachel Baggaley, Robert M Grant, Michelle Rodolph, Ioannis Hodges-Mameletzis, Caitlin E Kennedy
Daily oral pre-exposure prophylaxis (PrEP) is the use of antiretroviral drugs by HIV-negative people to prevent HIV infection. WHO released new guidelines in 2015 recommending PrEP for all populations at substantial risk of HIV infection. To prepare these guidelines, we conducted a systematic review of values and preferences among populations that might benefit from PrEP, women, heterosexual men, young women and adolescent girls, female sex workers, serodiscordant couples, transgender people and people who inject drugs, and among healthcare providers who may prescribe PrEP...
November 29, 2016: AIDS and Behavior
https://www.readbyqxmd.com/read/27900293/combined-use-of-platelet-rich-plasma-micro-fat-in-sport-and-race-horses-with-degenerative-joint-disease-preliminary-clinical-study-in-eight-horses
#17
Fabrizio Bembo, Julia Eraud, Cecile Philandrianos, Baptiste Bertrand, Alain Silvestre, Julie Veran, Florence Sabatier, Guy Magalon, Jeremy Magalon
BACKGROUND: To assess the safety and potential efficacy of a standardized technique consisting of intra-articular injection of 10 cc of a homogeneous mixed product using autologous micro-fat and platelet rich plasma (PRP) (ratio 1:1) in the carpus or the fetlock joint of sport horses presenting degenerative joint disease (DJD). METHODS: Eight sport horses with DJD confirmed by radiography and ultrasonography and causing lameness and the impossibility to compete were treated...
April 2016: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/27898598/pharmacokinetics-of-mycophenolic-acid-and-dose-optimization-in-children-after-intestinal-transplantation
#18
Caroline Barau, Antonio Mellos, Stéphanie Chhun, Florence Lacaille, Valérie Furlan
BACKGROUND: Mycophenolate mofetil (MMF) or enteric-coated mycophenolate sodium (MPS) are now commonly used in pediatric intestinal transplantation (Tx), but to date, no clear recommendations regarding the dosing regimen have been made in this population. The aim of this study was to determine the MMF/MPS dosage required to achieve an area under the plasma concentration-time curve from 0 to 12 hours (AUC0-12) for mycophenolic acid (MPA) greater than 30 mg.h/L in children after intestinal transplantation...
November 28, 2016: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/27895510/the-psychological-profile-of-women-presenting-to-a-multidisciplinary-clinic-for-chronic-pelvic-pain-high-levels-of-psychological-dysfunction-and-implications-for-practice
#19
Christina Bryant, Rebecca Cockburn, Anne-Florence Plante, Angela Chia
OBJECTIVE: Chronic pelvic pain (CPP) is widely acknowledged as a common problem with significant consequences for those diagnosed with this condition. There is a lack of studies with good sample size that provide a comprehensive psychological profile of women presenting to specialist chronic pain clinics. Therefore, the objective of this study was to describe the psychological profile of a representative sample of women presenting with CPP at a tertiary referral center. DESIGN: This was a cross-sectional study...
2016: Journal of Pain Research
https://www.readbyqxmd.com/read/27895328/regulatory-watch-challenges-in-drug-development-for-central-nervous-system-disorders-a-european-medicines-agency-perspective
#20
Florence Butlen-Ducuing, Frank Pétavy, Lorenzo Guizzaro, Malgorzata Zienowicz, Manuel Haas, Enrica Alteri, Tomas Salmonson, Emmanuelle Corruble
No abstract text is available yet for this article.
November 29, 2016: Nature Reviews. Drug Discovery
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