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https://www.readbyqxmd.com/read/28092690/post-translational-selective-intracellular-silencing-of-acetylated-proteins-with-de-novo-selected-intrabodies
#1
Michele Chirichella, Simonetta Lisi, Marco Fantini, Martina Goracci, Mariantonietta Calvello, Rossella Brandi, Ivan Arisi, Mara D'Onofrio, Cristina Di Primio, Antonino Cattaneo
The ability to selectively interfere with post-translationally modified proteins would have many biological and therapeutic applications. However, post-translational modifications cannot be selectively targeted by nucleic-acid-based interference approaches. Here we describe post-translational intracellular silencing antibody technology (PISA), a method for selecting intrabodies against post-translationally modified proteins. We demonstrate our method by generating intrabodies against native acetylated proteins and showing functional interference in living cells...
January 16, 2017: Nature Methods
https://www.readbyqxmd.com/read/28091795/mood-spectrum-disorders-and-perception-of-pain
#2
Antonella Ciaramella
: Evaluation of pain perception in chronic pain patients with a concomitant mood-spectrum disorder. DESIGN: The observational retrospective study is based on patient data collected in psychosomatic consultations held at the Gift Institute for Integrative Medicine in Pisa, Italy, from 2002 to 2014. Evoked pain stimulus threshold and tolerance were evaluated using the cold pressor test. Clinical pain intensity and Sensorial, Affective, and Evaluative dimensions were assessed using the Italian Pain Questionnaire, and Anxiety and Depressive symptoms using the Hospital Anxiety Depression Scale...
January 14, 2017: Psychiatric Quarterly
https://www.readbyqxmd.com/read/28072641/sensory-hypersensitivity-predicts-reduced-sleeping-quality-in-patients-with-major-affective-disorders
#3
Batya Engel-Yeger, Xenia Gonda, Muffy Walker, Zoltan Rihmer, Maurizio Pompili, Mario Amore, Gianluca Serafini
The goal of this study was to examine the sensory profile (expressed as hypersensitivity or hyposensitivity) of patients with major affective disorders and its relative contribution to the prediction of sleep quality while considering affective temperaments and depression, which may impact sleep quality. We recruited 176 participants (mean age, 47.3 y), of whom 56.8% had a diagnosis of unipolar major depressive disorder and 43.2% a diagnosis of bipolar disorder. Reduced sleep quality was evaluated using the Pittsburgh Sleep Quality Index...
January 2017: Journal of Psychiatric Practice
https://www.readbyqxmd.com/read/28050765/association-of-periodontal-disease-with-glycemic-control-in-patients-with-type-2-diabetes-in-indian-population
#4
Palka Kaur Khanuja, Satish Chander Narula, Rajesh Rajput, Rajinder Kumar Sharma, Shikha Tewari
This study aims to investigate the link between glycated hemoglobin and diabetic complications with chronic periodontitis. A total of 207 patients with type 2 diabetes and chronic periodontitis (CP) were divided according to tertiles of mean PISA (periodontal inflamed surface area) scores as low, middle and high PISA groups. Simultaneously a group of 67 periodontally healthy individuals (PH) was recruited. Periodontal examinations, including full-mouth assessment of probing depths (PPD), bleeding on probing, clinical attachment level and plaque scores were determined...
January 3, 2017: Frontiers of Medicine
https://www.readbyqxmd.com/read/28024776/comparison-of-reconstructed-rapid-prototyping-models-produced-by-3-dimensional-printing-and-conventional-stone-models-with-different-degrees-of-crowding
#5
Wan Nurazreena Wan Hassan, Yusnilawati Yusoff, Noor Azizi Mardi
INTRODUCTION: Rapid prototyping models can be reconstructed from stereolithographic digital study model data to produce hard-copy casts. In this study, we aimed to compare agreement and accuracy of measurements made with rapid prototyping and stone models for different degrees of crowding. METHODS: The Z Printer 450 (3D Systems, Rock Hill, SC) reprinted 10 sets of models for each category of crowding (mild, moderate, and severe) scanned using a structured-light scanner (Maestro 3D, AGE Solutions, Pisa, Italy)...
January 2017: American Journal of Orthodontics and Dentofacial Orthopedics
https://www.readbyqxmd.com/read/27997593/predictors-of-information-technology-integration-in-secondary-schools-evidence-from-a-large-scale-study-of-more-than-30-000-students
#6
Khe Foon Hew, Cheng Yong Tan
The present study examined the predictors of information technology (IT) integration in secondary school mathematics lessons. The predictors pertained to IT resource availability in schools, school contextual/institutional variables, accountability pressure faced by schools, subject culture in mathematics, and mathematics teachers' pedagogical beliefs and practices. Data from 32,256 secondary school students from 2,519 schools in 16 developed economies who participated in the Program for International Student Assessment (PISA) 2012 were analyzed using hierarchical linear modeling (HLM)...
2016: PloS One
https://www.readbyqxmd.com/read/27986355/the-prolyl-oligopeptidase-inhibitor-ipr19-ameliorates-cognitive-deficits-in-mouse-models-of-schizophrenia
#7
Roger Prades, Eva Munarriz-Cuezva, Leyre Urigüen, Itziar Gil-Pisa, Lídia Gómez, Laura Mendieta, Soledad Royo, Ernest Giralt, Teresa Tarragó, J Javier Meana
Cognitive deficits are considered a key feature of schizophrenia, and they usually precede the onset of the illness and continue after psychotic symptoms appear. Current antipsychotic drugs have little or no effect on the cognitive deficits of this disorder. Prolyl oligopeptidase (POP) is an 81-kDa monomeric serine protease that is expressed in brain and other tissues. POP inhibitors have shown neuroprotective, anti-amnesic and cognition-enhancing properties. Here we studied the potential of IPR19, a new POP inhibitor, for the treatment of the cognitive symptoms related to schizophrenia...
December 13, 2016: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27958450/advances-in-infrared-technology-and-applications-introduction
#8
Marija Strojnik, Mario D'Acunto, Antoni Rogalski
The special issue of Applied Optics on Advanced Infrared Technology and Applications(AITA) arose out of the biannual conference of the same name, most recently held in Pisa, Italy, 29 September to 2 October, 2015.
December 1, 2016: Applied Optics
https://www.readbyqxmd.com/read/27958421/higher-q-factor-and-higher-extinction-ratio-with-lower-detection-limit-photonic-crystal-parallel-integrated-sensor-array-for-on-chip-optical-multiplexing-sensing
#9
Jian Zhou, Lijun Huang, Zhongyuan Fu, Fujun Sun, Huiping Tian
We introduce an alternative method to establish a nanoscale sensor array based on a photonic crystal (PhC) slab, which is referred to as a 1×4 monolithic PhC parallel-integrated sensor array (PhC-PISA). To realize this function, four lattice-shifted resonant cavities are butt-coupled to four output waveguide branches, respectively. By shifting the first to the two closest neighboring holes around the defect, a high Q factor over 1.5×10<sup>4</sup> has been obtained. Owing to the slightly different cavity spacing, each PhC resonator shows an independent resonant peak shift as the refractive index changes surrounding the resonant cavity...
December 10, 2016: Applied Optics
https://www.readbyqxmd.com/read/27942199/parental-resources-sibship-size-and-educational-performance-in-20-countries-evidence-for-the-compensation-model
#10
Antti O Tanskanen, Jani Erola, Johanna Kallio
We study whether having several siblings decreases the level of educational performance of adolescents and whether this phenomenon can be compensated by other factors such as the economic or cultural resources of the parents. Based on this compensation model, parental resources should be associated with children's educational attainments more strongly in families with a higher rather than a lower number of children. We analyzed the Program for International Student Assessment (PISA) data from 20 Western countries and found that better family wealth, an increased level of parental education, and a higher parental occupational status were associated with increased educational attainments more strongly among 15-year-old children who have siblings than among children without siblings...
December 2016: Cross-cultural Research: Official Journal of the Society for Cross-Cultural Research
https://www.readbyqxmd.com/read/27935442/psychosis-after-switch-in-opioid-maintenance-agonist-and-risperidone-induced-pisa-syndrome-two-critical-incidents-in-the-treatment-of-a-patient-with-dual-diagnosis
#11
Manuel Sutter, Marc Walter, Kenneth M Dürsteler, Johannes Strasser, Marc Vogel
BACKGROUND AND AIMS: Dual diagnosis commonly occurs among patients with an opioid use disorder. Treatment is ideally performed in an integrated fashion. We present a case which illustrates the complex and challenging psychiatric and medical therapy of such patients in the light of the literature. CASE DESCRIPTION: We report on a 56-year old patient diagnosed with schizophrenia and opioid dependence that suffered both from a risperidone-induced Pisa syndrome and, three years later, an acute psychosis after switching the opioid substitution medication from methadone to slow-release oral morphine due to QT-prolongation...
December 9, 2016: Journal of Dual Diagnosis
https://www.readbyqxmd.com/read/27921080/echo-and-bnp-serial-assessment-in-ambulatory-heart-failure-care-data-on-loop-diuretic-use-and-renal-function
#12
Frank Lloyd Dini, Anca Simioniuc, Erberto Carluccio, Stefano Ghio, Andrea Rossi, Paolo Biagioli, Gianpaolo Reboldi, Gian Giacomo Galeotti, Fei Lu, Cornelia Zara, Gillian Whalley, Pier Luigi Temporelli
We compared the follow-up data on loop diuretic use and renal function, as assessed by serum creatinine levels, and the estimated glomerular filtration rate (eGFR), of two groups of consecutive ambulatory HF patients: 1) the clinically-guided group, in which management was clinically driven based on the institutional protocol of the HF Unit of the Cardiovascular and Thoracic Department of Pisa (standard of care) and 2) the echo and B-type natriuretic peptide (BNP) guided group (patients conforming to the protocol of the Network Labs Ultrasound (NEBULA) in HF Study Group: Pisa, Perugia, Pavia; Verona, Auckland, and Veruno), in which therapy was delivered according to the serial assessment of BNP and echocardiography...
December 2016: Data in Brief
https://www.readbyqxmd.com/read/27917132/testlet-based-multidimensional-adaptive-testing
#13
Andreas Frey, Nicki-Nils Seitz, Steffen Brandt
Multidimensional adaptive testing (MAT) is a highly efficient method for the simultaneous measurement of several latent traits. Currently, no psychometrically sound approach is available for the use of MAT in testlet-based tests. Testlets are sets of items sharing a common stimulus such as a graph or a text. They are frequently used in large operational testing programs like TOEFL, PISA, PIRLS, or NAEP. To make MAT accessible for such testing programs, we present a novel combination of MAT with a multidimensional generalization of the random effects testlet model (MAT-MTIRT)...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27908217/the-evaluation-of-temperament-and-quality-of-life-in-patients-with-polycystic-ovary-syndrome
#14
Zeynep Ozcan Dag, Murat Alpua, Yuksel Isik, S Visal Buturak, Ozlem B Tulmac, Yakup Turkel
AIMS: To evaluate the temperament and quality of life (QoL) of patients with PCOS. MATERIALS AND METHODS: Fifty-three adult patients with PCOS and 38 healthy controls were enrolled in the study. Demographic characteristics including age, education and body mass index (BMI) were recorded. Affective temperaments were assessed by the temperament evaluation of Memphis, Pisa, Paris and San Diego-autoquestionnaire version (TEMPS-A) scale. The general health-related quality of life (HRQoL) instrument used in this study was short Form 36...
December 2, 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/27900822/stimulus-responsive-nanoparticles-and-associated-reversible-polymorphism-via-polymerization-induced-self-assembly-pisa
#15
Yiwen Pei, Andrew B Lowe, Peter J Roth
Polymerization-induced self-assembly (PISA) is an extremely versatile method for the in situ preparation of soft-matter nanoparticles of defined size and morphologies at high concentrations, suitable for large-scale production. Recently, certain PISA-prepared nanoparticles have been shown to exhibit reversible polymorphism ("shape-shifting"), typically between micellar, worm-like, and vesicular phases (order-order transitions), in response to external stimuli including temperature, pH, electrolytes, and chemical modification...
January 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/27899986/metastasis-of-renal-cell-carcinoma-to-the-parathyroid-gland-16-years-after-radical-nephrectomy-a-case-report
#16
Liborio Torregrossa, Maria Isabella Rotondo, Andrea Cacciato Insilla, David Galleri, Federica Guidoccio, Paolo Miccoli, Virginia A Livolsi, Fulvio Basolo
Renal cell carcinoma (RCC) has a high metastatic potential, and most commonly metastasizes via the bloodstream, although lymphatic metastases also occur. RCC is well-known for its propensity to metastasize to unusual sites, and late metastasis, even after a number of years, is common. The occurrence of RCC metastasis to the head and neck region is uncommon, and occurs primarily in the thyroid gland and in patients with widespread dissemination. Involvement of the parathyroid gland in metastatic carcinoma is extremely rare...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27890771/echocardiographic-determinants-of-one-year-all-cause-mortality-in-patients-with-chronic-heart-failure-complicated-by-significant-functional-tricuspid-regurgitation
#17
Kai Hu, Dan Liu, Stefan Störk, Sebastian Herrmann, Daniel Oder, Georg Ertl, Wolfram Voelker, Frank Weidemann, Peter Nordbeck
BACKGROUND: Right ventricular (RV) dysfunction plays an important role in chronic heart failure (CHF). We evaluated the echocardiographic determinants of 1-year all-cause mortality in CHF patients with clinically relevant functional tricuspid regurgitation (TR). METHODS AND RESULTS: A total of 101 consecutive CHF patients (mean age 74 ± 10 years, 53% male) with moderate or severe functional TR were enrolled. Each patient underwent at least 2 echocardiography examinations in an interval of >6 months...
November 24, 2016: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/27888682/affective-temperaments-as-measured-by-temps-a-among-self-poisoning-nonlethal-suicide-attempters
#18
Amir Rezaei Ardani, Farhad Farid Hosseini, Zahra Asadpour, Amir Masoud Hashemian, Bita Dadpour, Mahsa Nahidi
Suicidal behaviors are serious public health problems. The prominent association of mood disorders with suicide, along with the renaissance of the spectrum concept of psychiatric disorders in the recent decades, prioritizes the investigation of temperament variants in suicidal individuals. This study aimed to explore the relationship between affective temperaments and nonviolent suicide attempts. We administered Temperament Evaluation of the Memphis, Pisa, Paris, and San Diego Auto questionnaire (TEMPS-A) to 141 (27 males and 114 females) consecutive self-poisoning non-lethal suicide attempters at a Medical Toxicology Center and a sex and age matched group of healthy individuals (28 males, 112 females)...
January 2017: Psychiatry Research
https://www.readbyqxmd.com/read/27875918/expected-and-actual-adverse-drug-drug-interactions-in-elderly-patients-accessing-the-emergency-department-data-from-the-ancestral-ed-study
#19
A Marino, A Capogrosso-Sansone, M Tuccori, G Bini, V Calsolaro, S Mantarro, I Convertino, G Pasqualetti, E Orsitto, M Santini, F Monzani, C Blandizzi
OBJECTIVE: This study was aimed at evaluating the frequency and describing the adverse drug-drug interactions (DDIs) recorded among elderly patients accessing the emergency department (ED). METHODS: Patients aged ≥65 years, accessing the ED of Pisa University Hospital (Italy) from 1 January 2015 to 31 December 2015 within the ANCESTRAL-ED program, were included in this study. 'Expected' DDIs were assessed using Thomson Micromedex®. Each ED admission (discharge diagnosis) consistent with the signs and symptoms of an expected DDI for each patient was classified as an 'actual' DDI...
December 2016: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/27872620/fungal-enolase-%C3%AE-tubulin-and-chitin-are-detected-in-brain-tissue-from-alzheimer-s-disease-patients
#20
Diana Pisa, Ruth Alonso, Alberto Rábano, Michael N Horst, Luis Carrasco
Recent findings provide evidence that fungal structures can be detected in brain tissue from Alzheimer's disease (AD) patients using rabbit polyclonal antibodies raised against whole fungal cells. In the present work, we have developed and tested specific antibodies that recognize the fungal proteins, enolase and β-tubulin, and an antibody that recognizes the fungal polysaccharide chitin. Consistent with our previous studies, a number of rounded yeast-like and hyphal structures were detected using these antibodies in brain sections from AD patients...
2016: Frontiers in Microbiology
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