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https://www.readbyqxmd.com/read/28314176/metronomic-and-metronomic-like-therapies-in-neuroendocrine-tumors-rationale-and-clinical-perspectives
#1
REVIEW
Ioana Lambrescu, Simona Fica, Diana Martins, Francesca Spada, Chiara Cella, Emilio Bertani, Manila Rubino, Bianca Gibelli, Chiara Grana, Guido Bonomo, Luigi Funicelli, Davide Ravizza, Eleonora Pisa, Dario Zerini, Antonio Ungaro, Nicola Fazio
Metronomic therapy is characterized by the administration of regular low doses of certain drugs with very low toxicity. There have been numerous debates over the empirical approach of this regimen, but fewest side effects are always something to consider in order to improve patients' quality of life. Neuroendocrine tumors (NETs) are rare malignancies relatively slow-growing; therefore their treatment is often chronic, involving several different therapies for tumor growth control. Knowing that these tumors are highly vascularized, the anti-angiogenic aspect is highly regarded as something to be targeted in all patients harboring NETs...
February 24, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/28290193/molecularly-imprinted-plasmonic-substrates-for-specific-and-ultrasensitive-immunoassay-of-trace-glycoproteins-in-biological-samples
#2
Pir Muhammad, Xueying Tu, Jia Liu, Yijia Wang, Zhen Liu
Assays of glycoproteins hold significant biological importance and clinical values, for which immunoassay has been the workhorse tool. As immunoassays are associated with disadvantages such as poor availability of high-specificity antibodies, limited stability of biological reagents, and tedious procedure, innovative alternatives that can overcome these drawbacks are highly desirable. Plasmonic immunosandwich assay (PISA) has emerged as an appealing alternative to immunoassay for fast and sensitive determination of trace glycoproteins in biosamples...
March 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28282886/chroman-4-one-derivatives-targeting-pteridine-reductase-1-and-showing-anti-parasitic-activity
#3
Flavio Di Pisa, Giacomo Landi, Lucia Dello Iacono, Cecilia Pozzi, Chiara Borsari, Stefania Ferrari, Matteo Santucci, Nuno Santarem, Anabela Cordeiro-da-Silva, Carolina B Moraes, Laura M Alcantara, Vanessa Fontana, Lucio H Freitas-Junior, Sheraz Gul, Maria Kuzikov, Birte Behrens, Ina Pöhner, Rebecca C Wade, Maria Paola Costi, Stefano Mangani
Flavonoids have previously been identified as antiparasitic agents and pteridine reductase 1 (PTR1) inhibitors. Herein, we focus our attention on the chroman-4-one scaffold. Three chroman-4-one analogues (1-3) of previously published chromen-4-one derivatives were synthesized and biologically evaluated against parasitic enzymes (Trypanosoma brucei PTR1-TbPTR1 and Leishmania major-LmPTR1) and parasites (Trypanosoma brucei and Leishmania infantum). A crystal structure of TbPTR1 in complex with compound 1 and the first crystal structures of LmPTR1-flavanone complexes (compounds 1 and 3) were solved...
March 8, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28282082/-narratives-in-psychiatry
#4
Hugo Pisa
No abstract text is available yet for this article.
July 2016: Vertex: Revista Argentina de Psiquiatriá
https://www.readbyqxmd.com/read/28281005/a-clinical-study-of-the-coronal-plane-deformity-in-parkinson-disease
#5
Xiaoyun Ye, Danning Lou, Xueping Ding, Chaoyan Xie, Jixiang Gao, Yuting Lou, Zhidong Cen, Yuxiang Xiao, Qianzhuang Miao, Fei Xie, Xiaosheng Zheng, Jianxin Wu, Fangcai Li, Wei Luo
BACKGROUND: Postural deformities in the coronal plane were frequent and disabling complications of PD, which reduces the quality of life of patients. This study aimed to garner greater attention to the Parkinson disease (PD)-related postural trunk deviations in the coronal plane by exploring a method for diagnosis because of the lack of any uniform diagnostic criteria and epidemiological studies. It also aimed to provide correlation data in the Chinese PD patients. METHODS: In this cross-sectional study, 503 consecutive outpatients with PD were enrolled who underwent standardized clinical evaluation...
March 9, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28277592/evaluation-of-the-effects-of-the-metha-short-stem-on-periprosthetic-bone-remodelling-in-total-hip-arthroplasties-results-at-48-months
#6
Paolo D Parchi, Gianluca Ciapini, Iacopo Castellini, Claudia Mannucci, Anna Maria Nucci, Nicola Piolanti, Silvia Maffei, Michele Lisanti
INTRODUCTION: Total hip arthroplasty is one of the most performed procedures in orthopaedic surgery. Implantation of a prosthesis determines changes in the distribution of loads on the host bone, and this phenomenon, known as stress shielding, is related to the biomechanical characteristics of the implant. Usually stress shielding involves the proximal portion of the femur by reducing the mechanical strength and ability to withstand the transmitted loads. The aim of our study is to demonstrate how the use of a short hip stem reduces the stress shielding phenomenon to the proximal femur...
March 9, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/28275224/aggressive-versus-conservative-antibiotic-use-to-prevent-and-treat-ventilator-associated-pneumonia-in-patients-with-severe-traumatic-brain-injury-comparison-of-two-case-series
#7
Arturo Chieregato, Paolo Malacarne, Francesco Cocciolo, Maurizio Ravaldini, Emanuele Russo, Bruno Viaggi, Michele Giardino, Carlotta Rossi, Bruno Simini, Guido Bertolini
BACKGROUND: In patients with traumatic brain injury (TBI), ventilator-associated pneumonia (VAP) is considered a dangerous complication, prompting early aggressive antibiotic treatment and prophylaxis. While this approach increases the selection of multidrug-resistant bacteria (MDR), its clinical benefit has not been demonstrated. METHODS: One-year incidence of VAP in severe TBI patients (ICU stay >48 hours, with either Glasgow Coma Scale 8 or receiving intracranial pressure monitoring, or having undergone emergency surgery) and the prevalence of MDR among those who eventually developed it, were compared in two Italian intensive care units (ICUs) adopting different antibiotic approaches...
March 8, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/28274714/quantification-of-multiple-mitral-regurgitant-jets-an-in%C3%A2-vitro-validation-study-comparing-two-and-three-dimensional-proximal-isovelocity-surface-area-methods
#8
Fabian Zürcher, Nicolas Brugger, Silje Ekroll Jahren, Stefano Fausto de Marchi, Christian Seiler
BACKGROUND: The accuracy of the proximal isovelocity surface area (PISA) method for the quantification of mitral regurgitation (MR), in the case of multiple jets, is unknown. The aim of this study was to evaluate different two-dimensional (2D) and three-dimensional (3D) PISA methods using 3D color Doppler data sets. METHODS: Several regurgitant volumes (Rvols) were simulated using a pulsatile pump connected to a phantom equipped with single and double regurgitant orifices of different sizes and interspaces...
March 5, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28272700/use-of-robotic-colonoscopy-in-patients-with-previous-incomplete-colonoscopy
#9
E Tumino, G Parisi, M Bertoni, M Bertini, S Metrangolo, E Ierardi, R Cervelli, G Bresci, R Sacco
OBJECTIVE: Conventional colonoscopy (CC) is the gold standard to diagnostic and therapeutic approach to colon. However, in few cases, cecal intubation could fail due to colon anatomy, patient compliance and physician expertise. Endotics robotic colonoscopy is a novel, safe, mini-invasive modality to explore the entire colon. Our aim was to assess, in a retrospective study, Endotics ability of cecal intubation in all cases in which CC failed. PATIENTS AND METHODS: Between January 2008 and December 2012, 276 Endotics robotic colonscopy examinations were performed at the Gastroenterology and Metabolic Diseases Unit of Pisa University Hospital, Pisa, Italy, in a series of consecutive patients who had undergone CC and failed cecal intubation...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28264671/lifestyles-and-socio-cultural-factors-among-children-aged-6-8-years-from-five-italian-towns-the-mapec_life-study-cohort
#10
Francesco Bagordo, Antonella De Donno, Tiziana Grassi, Marcello Guido, Gabriele Devoti, Elisabetta Ceretti, Claudia Zani, Donatella Feretti, Milena Villarini, Massimo Moretti, Tania Salvatori, Annalaura Carducci, Marco Verani, Beatrice Casini, Sara Bonetta, Elisabetta Carraro, Tiziana Schilirò, Silvia Bonizzoni, Alberto Bonetti, Umberto Gelatti
BACKGROUND: Lifestyles profoundly determine the quality of an individual's health and life since his childhood. Many diseases in adulthood are avoidable if health-risk behaviors are identified and improved at an early stage of life. The aim of the present research was to characterize a cohort of children aged 6-8 years selected in order to perform an epidemiological molecular study (the MAPEC_LIFE study), investigate lifestyles of the children that could have effect on their health status, and assess possible association between lifestyles and socio-cultural factors...
March 7, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28260814/preparation-and-cross-linking-of-all-acrylamide-diblock-copolymer-nano-objects-via-polymerization-induced-self-assembly-in-aqueous-solution
#11
Sarah J Byard, Mark Williams, Beulah E McKenzie, Adam Blanazs, Steven P Armes
Various carboxylic acid-functionalized poly( N , N -dimethylacrylamide) (PDMAC) macromolecular chain transfer agents (macro-CTAs) were chain-extended with diacetone acrylamide (DAAM) by reversible addition-fragmentation chain transfer (RAFT) aqueous dispersion polymerization at 70 °C and 20% w/w solids to produce a series of PDMAC-PDAAM diblock copolymer nano-objects via polymerization-induced self-assembly (PISA). TEM studies indicate that a PDMAC macro-CTA with a mean degree of polymerization (DP) of 68 or higher results in the formation of well-defined spherical nanoparticles with mean diameters ranging from 40 to 150 nm...
February 28, 2017: Macromolecules
https://www.readbyqxmd.com/read/28252143/self-assembly-of-poly-lauryl-methacrylate-b-poly-benzyl-methacrylate-nano-objects-synthesised-by-atrp-and-their-temperature-responsive-dispersion-properties
#12
Melody Obeng, Amir H Milani, Muhamad S Musa, Zhengxing Cui, Lee A Fielding, Louise Farrand, Mark Goulding, Brian R Saunders
Self-assembling poly(lauryl methacrylate)-b-poly(benzyl methacrylate) (PLMAx-PBzMAy) diblock copolymers were synthesised for the first time using solution atom transfer radical polymerisation (ATRP). The PLMA degree of polymerisation (x) was fixed at 14 and the PBzMA degree of polymerisation (y) was varied from 34 to 74. Post-polymerisation transfer of this new series of diblock copolymers from chloroform into n-dodecane (a poor solvent for PBzMA) resulted in self-assembly of polymeric nano-objects. The morphologies for the latter (spheres, worms and vesicles) were controlled by y...
March 2, 2017: Soft Matter
https://www.readbyqxmd.com/read/28251008/osteopathic-manipulative-treatment-limits-chronic-constipation-in-a-child-with-pitt-hopkins-syndrome
#13
Alessandro Aquino, Mattia Perini, Silvia Cosmai, Silvia Zanon, Viviana Pisa, Carmine Castagna, Stefano Uberti
Pitt-Hopkins Syndrome (PTHS) is a rare genetic disorder caused by insufficient expression of the TCF4 gene. Children with PTHS typically present with gastrointestinal disorders and early severe chronic constipation is frequently found (75%). Here we describe the case of a PTHS male 10-year-old patient with chronic constipation in whom Osteopathic Manipulative Treatment (OMT) resulted in improved bowel functions, as assessed by the diary, the QPGS-Form A Section C questionnaire, and the Paediatric Bristol Stool Form Scale...
2017: Case Reports in Pediatrics
https://www.readbyqxmd.com/read/28238587/clinical-implications-of-three-dimensional-real-time-color-doppler-transthoracic-echocardiography-in-quantifying-mitral-regurgitation-a-comparison-with-conventional-two-dimensional-methods
#14
Ran Heo, Jang-Won Son, Briain Ó Hartaigh, Hyuk-Jae Chang, Young-Jin Kim, Saurabh Datta, In-Jeong Cho, Chi Young Shim, Geu-Ru Hong, Jong-Won Ha, Namsik Chung
BACKGROUND: Automatic quantification of real-time three-dimensional (3D) full-volume color Doppler transthoracic echocardiography (FVCD) has been proposed as a feasible and accurate method for quantifying MR. We aimed to explore the clinical implications of real-time 3D-FVCD for mitral regurgitation (MR) with various clinical manifestations, in comparison with the conventional two-dimensional (2D) proximal isovelocity surface area (PISA) and volumetric method and cardiac magnetic resonance imaging (CMR) methods...
February 23, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28229203/-real-time-3d-echocardiography-for-estimation-of-severity-in-valvular-heart-disease-impact-on-current-guidelines
#15
T Buck, L Bösche, B Plicht
Besides providing spatial anatomic information on heart valves, real-time three-dimensional echocardiography (3DE) combined with color Doppler has the potential to overcome the limitations of flow quantification inherent to conventional 2D color Doppler methods. Recent studies validated the application of color Doppler 3DE (cD-3DE) for the quantification of regurgitation flow based on the vena contracta area (VCA) and the proximal isovelocity surface area (PISA) methods. Particularly the assessment of VCA by cD-3DE led to a change of paradigm by understanding of the VCA as being strongly asymmetric in the majority of patients and etiologies...
February 22, 2017: Herz
https://www.readbyqxmd.com/read/28224184/irritable-temperament-profile-prevails-among-patients-with-boxer-fractures
#16
A Taşkesen, I Demirkale, N Taşkesen, M Okumuş, D Ö Can
OBJECTIVE: The purpose of this prospective study was to examine the temperament dimensions of the patients with boxer fracture and compare them with age- and sex-matched controls. METHODS: We performed a prospective analysis investigating affective temperaments of the 102 patients with boxer fractures and compared them with 100 sex- and age-matched controls that were referred to the emergency department due to incidental soft-tissue trauma. Affective temperament of the patients was evaluated by Memphis, Pisa, Paris, and San Diego-Auto questionnaire (TEMPS-A)...
February 21, 2017: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/28222309/gemcitabine-erlotinib-versus-gemcitabine-erlotinib-capecitabine-in-the-first-line-treatment-of-patients-with-metastatic-pancreatic-cancer-efficacy-and-safety-results-of-a-phase-iib-randomised-study-from-the-spanish-ttd-collaborative-group
#17
Antonio Irigoyen, Javier Gallego, Carmen Guillén Ponce, Ruth Vera, Vega Iranzo, Inmaculada Ales, Sara Arévalo, Aleydis Pisa, Marta Martín, Antonieta Salud, Esther Falcó, Alberto Sáenz, José Luis Manzano Mozo, Gema Pulido, Joaquina Martínez Galán, Roberto Pazo-Cid, Fernando Rivera, Teresa García García, Olbia Serra, Eva Ma Fernández Parra, Alicia Hurtado, Ma José Gómez Reina, Luis Jesús López Gomez, Esther Martínez Ortega, Manuel Benavides, Enrique Aranda
BACKGROUND: Gemcitabine and erlotinib have shown a survival benefit in the first-line setting in metastatic pancreatic cancer (mPC). The aim of this study was to assess whether combining capecitabine (C) with gemcitabine + erlotinib (GE) was safe and effective versus GE in patients with mPC. PATIENTS AND METHODS: Previously untreated mPC patients were randomised to receive G (1000 mg/m(2), days 1, 8, 15) + E (100 mg/day, days 1-28) + C (1660 mg/m(2), days 1-21) or GE, q4 weeks, until progression or unacceptable toxicity...
February 17, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28220901/distinct-signatures-of-dental-plaque-metabolic-byproducts-dictated-by-periodontal-inflammatory-status
#18
Akito Sakanaka, Masae Kuboniwa, Ei Hashino, Takeshi Bamba, Eiichiro Fukusaki, Atsuo Amano
Onset of chronic periodontitis is associated with an aberrant polymicrobial community, termed dysbiosis. Findings regarding its etiology obtained using high-throughput sequencing technique suggested that dysbiosis holds a conserved metabolic signature as an emergent property. The purpose of this study was to identify robust biomarkers for periodontal inflammation severity. Furthermore, we investigated disease-associated metabolic signatures of periodontal microbiota using a salivary metabolomics approach. Whole saliva samples were obtained from adult subjects before and after removal of supragingival plaque (debridement)...
February 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28216792/effect-of-monomer-solubility-on-the-evolution-of-copolymer-morphology-during-polymerization-induced-self-assembly-in-aqueous-solution
#19
Amy A Cockram, Thomas J Neal, Matthew J Derry, Oleksandr O Mykhaylyk, Neal S J Williams, Martin W Murray, Simon N Emmett, Steven P Armes
Polymerization-induced self-assembly (PISA) has become a widely used technique for the rational design of diblock copolymer nano-objects in concentrated aqueous solution. Depending on the specific PISA formulation, reversible addition-fragmentation chain transfer (RAFT) aqueous dispersion polymerization typically provides straightforward access to either spheres, worms, or vesicles. In contrast, RAFT aqueous emulsion polymerization formulations often lead to just kinetically-trapped spheres. This limitation is currently not understood, and only a few empirical exceptions have been reported in the literature...
February 14, 2017: Macromolecules
https://www.readbyqxmd.com/read/28214173/pyrocarbon-interposition-shoulder-arthroplasty-preliminary-results-from-a-prospective-multicenter-study-at-2-years-of-follow-up
#20
Jérôme Garret, Arnaud Godeneche, Pascal Boileau, Daniel Molé, Mikael Etzner, Luc Favard, Christophe Levigne, François Sirveaux, Marc-Olivier Gauci, Charles Dezaly, Gilles Walch
BACKGROUND: The concept of free interposition arthroplasty proved successful for small joints of the hand, wrist, and foot, particularly after the use of implants coated with pyrocarbon, which enhanced their tribologic and elastic properties. The present study reports preliminary outcomes of a pyrocarbon-coated interposition shoulder arthroplasty (PISA) implant. METHODS: This was a prospective study of 67 consecutive patients who underwent shoulder PISA at 9 centers...
February 14, 2017: Journal of Shoulder and Elbow Surgery
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