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Adrian Andrzej Chrobak, Anna Tereszko, Daria Dembinska-Krajewska, Aleksandra Arciszewska, Marcin Siwek, Dominika Dudek, Janusz Rybakowski
Chronotype is a stable trait presenting one's circardian preference. Since chronotype disturbances are common in patients with affective disorders, our aim is to evaluate chronotypes related to affective temperaments, measured with the temperament evaluation of Memphis, Pisa and San Diego-Autoquestionnaire (TEMPS-A). The study included 618 subjects (151 men and 467 women) within the framework of web-based design. They all fulfilled a questionnaire, consisting of the Composite Scale of Morningness (CSM), Sleep Wake Pattern Assessment Questionnaire (SWPAQ), and the TEMPS-A scale...
October 13, 2016: Chronobiology International
Elie G Karam, Elaine El Khoury, Lynn Itani
BACKGROUND: An essential point in evaluating the utility of measuring temperaments is the stability of the instrument used especially in the presence of mental disorders. One of the most commonly used instruments in the clinical setting is the Temperament Evaluation of Memphis, Pisa, Paris and San Diego Auto-questionnaire (TEMPS-A). To our knowledge, the TEMPS-A's stability in an outpatient adult clinical setting has not been evaluated. OBJECTIVE: To assess the stability of the effect of temperament, time and clinical intervention...
2016: Clinical Practice and Epidemiology in Mental Health: CP & EMH
Pengcheng Yang, Oleksandr O Mykhaylyk, Elizabeth R Jones, Steven P Armes
We report a new nonaqueous polymerization-induced self-assembly (PISA) formulation based on the reversible addition-fragmentation chain transfer (RAFT) dispersion alternating copolymerization of styrene with N-phenylmaleimide using a nonionic poly(N,N-dimethylacrylamide) stabilizer in a 50/50 w/w ethanol/methyl ethyl ketone (MEK) mixture. The MEK cosolvent is significantly less toxic than the 1,4-dioxane cosolvent reported previously [Yang P.; Macromolecules2013, 46, 8545-8556]. The core-forming alternating copolymer block has a relatively high glass transition temperature (Tg), which leads to vesicular morphologies being observed during PISA, as well as the more typical sphere and worm phases...
September 27, 2016: Macromolecules
Maja Ivković, Maja Pantović-Stefanović, Nataša Petronijević, Bojana Dunjić-Kostić, Milica Velimirović, Tatjana Nikolić, Vladimir Jurišić, Maja Lačković, Sanja Totić-Poznanović, Aleksandar A Jovanović, Aleksandar Damjanović
BACKGROUND: Affective temperaments are intermediate phenotypes for major affective disorders and are reported to have a neuroimmune etiopathogenesis. Here we investigated the role of soluble intercellular cell adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) in affective temperaments and mood symptoms in healthy adults. METHODS: Healthy adults (n=94) were screened for psychiatric disorders using the nonpatient version of the Structured Clinical Interview for DSM-IV-I and II...
September 22, 2016: Journal of Affective Disorders
Thirupathi Dasari, Bhargavi Kondagari, Ramasree Dulapalli, Aboubakr Haredi Abdelmonsef, Thirupathi Mukkera, Lavanya Souda Padmarao, Vasavi Malkhed, Uma Vuruputuri
Cancer is a class of diseases characterized by uncontrolled cell growth. Every year More than 2 million people are affected by the disease. Rho family proteins are actively involved in cytoskeleton regulation. Over-expression of Rho family proteins show oncogenic activity and promote cancer progression. In the present work RhoG protein is considered as novel target of cancer. It is a member of Rho family and Rac subfamily protein, which plays pivotal role in regulation of microtubule formation, cell migration and contributes in cancer progression...
October 3, 2016: Journal of Biomolecular Structure & Dynamics
Emilie Viollet, Arnaud Dupeyron, Corine Gagnard-Landra
OBJECTIVE: Pisa syndrome (PS) is a common abnormal posture of the trunk in Parkinson disease which is defined as a lateral flexion of the spine in the coronal plane and/or scoliosis. Few studies described focal treatment of dystonia of paraspinal muscles, with unpredictable results, while the participation of quadratus lumborum and external oblique homolateral seem to be interesting. The aim of this study is to estimate the effects of treatment by botulinum toxin of trunk muscles dystonia in PS...
September 2016: Annals of Physical and Rehabilitation Medicine
Caterina Bernacchioni, Cecilia Pozzi, Flavio Di Pisa, Stefano Mangani, Paola Turano
Ferritins are iron-storage nanocage proteins that catalyze the oxidation of Fe(2+) to Fe(3+) at ferroxidase sites. By a combination of structural and spectroscopic techniques, Asp140, together with previously identified Glu57 and Glu136, is demonstrated to be an essential residue to promote the iron oxidation at the ferroxidase site. However, the presence of these three carboxylate moieties in close proximity to the catalytic centers is not essential to achieve binding of the Fe(2+) substrate to the diferric ferroxidase sites with the same coordination geometries as in the wild-type cages...
September 21, 2016: Chemistry: a European Journal
Xiao-Yun Zhang, Dong-Ming Liu, Xin-Hu Lv, Miao Sun, Xiao-Li Sun, Wen-Ming Wan
A one-pot method is introduced for the successful synthesis of narrow-distributed (Đ = 1.22) vinyl polymer with both ultrahigh molecular weight (UHMW) (M w = 1.31 × 10(6) g mol(-1) ) and micro-/nanomorphology under mild conditions. The method involves the following four stages: homogeneous polymerization, polymerization-induced self-assembly (PISA), PISA and reorganization, and PISA and multiple reorganizations. The key points to the production of UHMW polystyrene are to minimize radical termination by segregating radicals in different nanoreactors and to ensure sufficient chain propagation by promoting further reorganizations of these reactors in situ...
September 20, 2016: Macromolecular Rapid Communications
Jia Liu, Danyang Yin, Shuangshou Wang, Hong-Yuan Chen, Zhen Liu
Single-cell analysis techniques are essential for understanding the microheterogeneity and functions of cells. Low-copy-number proteins play important roles in cell functioning, but their measurement in single cells remains challenging. Herein, we report an approach, called plasmonic immunosandwich assay (PISA), for probing low-copy-number proteins in single cells. This approach combined in vivo immunoaffinity extraction and plasmon-enhanced Raman scattering (PERS). Target proteins were specifically extracted from the cells by microprobes modified with monoclonal antibody or molecularly-imprinted polymer (MIP), followed by labeling with Raman-active nanotags...
October 10, 2016: Angewandte Chemie
Pietro Muratori, Marinella Paciello, Carlo Buonanno, Annarita Milone, Laura Ruglioni, John E Lochman, Gabriele Masi
BACKGROUND: Callous-unemotional traits have been proposed as risk factors for a poorer prognosis in young people with disruptive behaviour disorders. Identification of factors that may cause or maintain elevated levels of such traits could help in developing targeted therapeutic interventions. Some previous studies have investigated the role of moral cognitive mechanisms, such as moral disengagement, but these previous studies focused primarily on normal or 'at-risk' samples. AIM: We aimed to evaluate associations and possible interactions between moral disengagement as a cognitive dimension and callous-unemotional traits as an affective dimension in adolescents with disruptive behaviour disorders...
September 13, 2016: Criminal Behaviour and Mental Health: CBMH
Yasuya Nakato, Takeshi Inoue, Shin Nakagawa, Yuji Kitaichi, Rie Kameyama, Yumi Wakatsuki, Kan Kitagawa, Yuki Omiya, Ichiro Kusumi
BACKGROUND: The Temperament Evaluation of the Memphis, Pisa, Paris, and San Diego Auto-questionnaire (TEMPS-A) is a 110-item questionnaire that assesses five affective temperaments. However, a valid shortened version is desired for large-scale investigations to enhance the compliance of respondents. METHODS: A confirmatory factor analysis was conducted among 320 psychiatric patients and 61 general adults. The participants completed the Japanese 39-item short version of the TEMPS-A, and a portion of the participants completed the 110-item version...
2016: Neuropsychiatric Disease and Treatment
Chang-Chih Tsou, San-Yuan Huang
OBJECTIVE: The aim of this paper is to present a case of paliperidone-induced Pisa syndrome and provide treatment experience. METHOD: The case report is combined with a review of the literature. RESULTS: A 37-year-old man had been diagnosed with paranoid-type schizophrenia for about 10 years. He received three-month treatment of paliperidone extended release (ER) at 6 mg per day, but showed a progressively Pisa-like physical position. We initially added an anticholinergic drug, but saw no improvement...
September 2, 2016: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
Francesca Parisi, Cristiana Berti, Chiara Mandò, Anna Martinelli, Cristina Mazzali, Irene Cetin
PURPOSE: Iron supplementation is associated with side effects and overload risk. We compared different regimens of iron supplementation on maternal hematological status and pregnancy outcome in a cohort of healthy pregnant women. MATERIALS AND METHODS: Eighty non-anemic women with a normal singleton pregnancy were recruited at 11-13 weeks and randomized into controls (C; n = 20) and groups supplemented with ferrous iron 30 mg (FI; n = 20), liposomal iron 14 mg (Sideral® Pharmanutra, Pisa PI, Italy) (LI14; n = 20) and liposomal iron 28 mg/daily (LI28; n = 20) up to 6 weeks post-partum...
September 2, 2016: Journal of Maternal-fetal & Neonatal Medicine
Giuseppe Aprile, Mariaelena Casagrande, Giovanna De Maglio, Caterina Fontanella, Karim Rihawi, Marta Bonotto, Federica E Pisa, Francesco Tuniz, Stefano Pizzolitto, Gianpiero Fasola
AIM: Little is known about molecular biology of brain metastasis (BM) from colorectal cancer and its concordance with matched primary tumors. MATERIALS & METHODS: We identified 56 consecutive colorectal cancer patients who underwent neurosurgical resection of BM. Tumor samples were tested for KRAS, NRAS, BRAF and PIK3CA. The molecular profile of the brain lesion was compared with the corresponding primary tumor. RESULTS: The molecular profile concordance rate was 95...
August 31, 2016: Future Oncology
Paolo Barone, Gabriella Santangelo, Marianna Amboni, Maria Teresa Pellecchia, Carmine Vitale
Pisa syndrome is defined as a reversible lateral bending of the trunk with a tendency to lean to one side. It is a frequent and often disabling complication of Parkinson's disease, and has also been described in several atypical forms of parkinsonism and in neurodegenerative and psychiatric disorders after drug exposure and surgical procedures. Although no consistent diagnostic criteria for Pisa syndrome are available, most investigations have adopted an arbitrary cutoff of at least 10° of lateral flexion for the diagnosis of the syndrome...
September 2016: Lancet Neurology
F Leccese, G Salvadori, M Rocca
BACKGROUND: Extensive literature in ergonomics and optometry has indicated that computer use is closely associated with visual problems. Computer-Aided Design (CAD) requires a substantial effort on behalf of the visual system. The manifestations of visual fatigue phenomena may affect the working behavior and the human-system interaction. OBJECTIVE: The aim of this survey is to identify the normal working conditions and how the eventual visual fatigue phenomena are able to influence the working behavior of CAD users...
August 12, 2016: Work: a Journal of Prevention, Assessment, and Rehabilitation
Letizia Marconi, Laura Carrozzi, Ferruccio Aquilini, Alessandro Celi, Francesco Pistelli, Antonio Palla
Benefits and harms of long-term anticoagulant therapy (AT) after acute pulmonary embolism (PE) are poorly known. The aim of this study was to investigate the outcome of patients with PE treated with AT for 5 years according to American College of Chest Physicians (ACCP) guidelines.Patients with both unprovoked and secondary PE were consecutively enrolled in a "real life" study. After a 12-month AT, they continued or stopped the treatment according to ACCP guidelines, and were followed-up for 5 years. Outcomes were all-cause mortality, recurrence, and fatal recurrence under AT...
August 2016: Medicine (Baltimore)
Wen-Jian Zhang, Chun-Yan Hong, Cai-Yuan Pan
A highly efficient strategy, polymerization-induced self-assembly (PISA) for fabrication of the polymeric drug delivery systems in cancer chemotherapy is reported. Diblock prodrug copolymer, PEG-b-P(MEO2MA-co-CPTM) was used as the macro-RAFT agent to fabricate prodrug nanoparticles through PISA. The advantages of fabricating intelligent drug delivery system via this approach are as following: (1) Simultaneous fulfillment of polymerization, self-assembly, and drug encapsulation in one-pot at relatively high concentration (100 mg/mL); (2) Almost complete monomer conversion allows direct application of the resultant prodrug nanoparticles without further purification; (3) Robust structures of the resultant prodrug nanoparticles, because the cross-linker was used as the comonomer, resulted in core-cross-linking simultaneously with the formation of the prodrug nanoparticles; (4) The drug content in the resultant prodrug nanoparticles can be accurately modulated just via adjusting the feed molar ratio of MEO2MA/CPTM in the synthesis of PEG-b-P(MEO2MA-co-CPTM)...
September 12, 2016: Biomacromolecules
Pedro T Pisa, Noleen M Pisa
BACKGROUND: To assess the trend associations between South Africa's economic growth using various economic growth indicators (EGIs) with adult obesity prevalence over a specified period of time. METHODS: Data for obesity levels reported were obtained from national surveys conducted in South African adults in 1998, 2003 and 2012. EGIs incorporated in the current analysis were obtained from the World Bank and IHS Global insight databases. Obesity prevalence is presented by gender, urbanisation level and ethnicity...
August 19, 2016: European Journal of Public Health
Yan Cheng, Huanhuan Gao, Liyan Tang, Jing Li, Lei Yao
OBJECTIVES: Implantable device leads could cause tricuspid regurgitation (TR) by interfering with leaflet motion. This study evaluated the feasibility of using three-dimensional transthoracic echocardiography (3DTTE) to identify lead-induced tricuspid regurgitation (LITR). METHODS: 3DTTE full-volume images of the right ventricle (RV) and zoomed images of the tricuspid valve were obtained in 207 patients with implanted devices, and the images were analyzed. TR severity was estimated based on measurements of the proximal isovelocity surface area (PISA) radius...
August 19, 2016: Echocardiography
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