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https://www.readbyqxmd.com/read/29226025/permeable-protein-loaded-polymersome-cascade-nanoreactors-by-polymerization-induced-self-assembly
#1
Lewis D Blackman, Spyridon Varlas, Maria C Arno, Alice Fayter, Matthew I Gibson, Rachel K O'Reilly
Enzyme loading of polymersomes requires permeability to enable them to interact with the external environment, typically requiring addition of complex functionality to enable porosity. Herein, we describe a synthetic route towards intrinsically permeable polymersomes loaded with functional proteins using initiator-free visible light-mediated polymerization-induced self-assembly (photo-PISA) under mild, aqueous conditions using a commercial monomer. Compartmentalization and retention of protein functionality was demonstrated using green fluorescent protein as a macro-molecular chromophore...
October 31, 2017: ACS Macro Letters
https://www.readbyqxmd.com/read/29225706/comparison-of-photo-and-thermally-initiated-polymerization-induced-self-assembly-a-lack-of-end-group-fidelity-drives-the-formation-of-higher-order-morphologies
#2
Lewis D Blackman, Kay E B Doncom, Matthew I Gibson, Rachel K O'Reilly
Polymerization-induced self-assembly (PISA) is an emerging industrially relevant technology, which allows the preparation of defined and predictable polymer self-assemblies with a wide range of morphologies. In recent years, interest has turned to photoinitiated PISA processes, which show markedly accelerated reaction kinetics and milder conditions, thereby making it an attractive alternative to thermally initiated PISA. Herein, we attempt to elucidate the differences between these two initiation methods using isothermally derived phase diagrams of a well-documented poly(ethylene glycol)-b-(2-hydroxypropyl methacrylate) (PEG-b-HPMA) PISA system...
May 14, 2017: Polymer Chemistry
https://www.readbyqxmd.com/read/29218774/impact-of-antiinfective-periodontal-therapy-on-parameters-of-vascular-health
#3
Yvonne Jockel-Schneider, Markus Bechtold, Imme Haubitz, Stefan Störk, Stefan Fickl, Inga Harks, Martin Eigenthaler, Oliver Vollrath, Johannes Baulmann, Ulrich Schlagenhauf
AIM: This study assessed the impact of antiinfective periodontal therapy on the status of vascular health. MATERIALS AND METHODS: Periodontal and vascular health of 55 patients with severe untreated chronic periodontitis was evaluated before and 12 months after antiinfective periodontal therapy. Observed parameters were bleeding on probing (BoP), pocket probing depth (PPD), periodontal inflamed surface area index (PISA), pulse wave velocity (PWV), augmentation index (AIx), central pulse pressure (PPao), and peripheral systolic pressure (RRsys)...
December 8, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/29209687/high-risk-of-brain-tumors-in-military-personnel-a-case-control-study
#4
P Fallahi, G Elia, R Foddis, A Cristaudo, A Antonelli
Scientific literature suggests a relationship between military occupation and the development of brain tumors, but no italian study has investigated on the impact of this job on the brain cancer morbidity. In this a study information were obtained from patients recruited in the Neurosurgical Department of the University-Hospital of Pisa, Italy, from 1990 to 1999. The study has been conducted as a case-control study. 161, newly diagnosed cases of brain tumors (glioma and meningiomas, histologically confirmed), were recruited, such as 483 controls (with other non tumoral neurologic diseases: trauma, hemorrhagic brain disorders, aneurism, etc), by matching cases and controls (1:3), for age (± 5 years) and gender...
November 2017: La Clinica Terapeutica
https://www.readbyqxmd.com/read/29201453/the-role-of-multimodal-treatment-in-patients-with-advanced-lung-neuroendocrine-tumors
#5
REVIEW
Nicola Fazio, Antonio Ungaro, Francesca Spada, Chiara Alessandra Cella, Eleonora Pisa, Massimo Barberis, Chiara Grana, Dario Zerini, Emilio Bertani, Dario Ribero, Luigi Funicelli, Guido Bonomo, Davide Ravizza, Juliana Guarize, Filippo De Marinis, Francesco Petrella, Ester Del Signore, Giuseppe Pelosi, Lorenzo Spaggiari
Lung neuroendocrine tumors (NETs) comprise typical (TC) and atypical carcinoids (AC). They represent the well differentiated (WD) or low/intermediate grade forms of lung neuroendocrine neoplasms (NENs). Unlike the lung poorly differentiated NENs, that are usually treated with chemotherapy, lung NETs can be managed with several different therapies, making a multidisciplinary interaction a key point. We critically discussed the multimodal clinical management of patients with advanced lung NETs. Provided that no therapeutic algorithm has been validate so far, each clinical case should be discussed within a NEN-dedicated multidisciplinary team...
November 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29185358/simplified-summative-temporal-bone-dissection-scale-demonstrates-equivalence-to-existing-measures
#6
Justyn Pisa, Michael Gousseau, Stephanie Mowat, Brian Westerberg, Bert Unger, Jordan B Hochman
INTRODUCTION: Emphasis on patient safety has created the need for quality assessment of fundamental surgical skills. Existing temporal bone rating scales are laborious, subject to evaluator fatigue, and contain inconsistencies when conferring points. To address these deficiencies, a novel binary assessment tool was designed and validated against a well-established rating scale. METHODS: Residents completed a mastoidectomy with posterior tympanotomy on identical 3D-printed temporal bone models...
November 1, 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/29167036/inverse-association-between-hyperthymic-affective-temperament-and-coronary-atherosclerosis-a-coronary-computed-tomography-angiography-study
#7
János Nemcsik, Milán Vecsey-Nagy, Bálint Szilveszter, Márton Kolossváry, Júlia Karády, Andrea László, Beáta Kőrösi, Zsófia Nemcsik-Bencze, Xénia Gonda, Béla Merkely, Zoltán Rihmer, Pál Maurovich-Horvat
OBJECTIVE: A bidirectional relationship exists between psychiatric disorders and cardiovascular diseases, however less is known with regards to personality traits. Accumulating data suggest that affective temperaments are both associated with psychiatric and somatic diseases. The aim of our study was to evaluate the associations between different affective temperaments and the presence of coronary atherosclerosis. METHODS: 200 consecutive patients referred to coronary computed tomography angiography (CCTA) due to suspected coronary artery disease (CAD) were included in our study...
December 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/29166641/agrowastes-as-feedstock-for-the-production-of-endo-%C3%AE-xylanase-from-cohnella-sp-strain-ar92
#8
José H Pisa, Adriana P Manfredi, Nora I Perotti, Héctor G Romero, Javier D Breccia, María Alejandra Martínez
Members of Cohnella sp. isolated from a variety of environments have been shown to be glycoside hydrolase producers. Nevertheless, most evaluations of members of this genus are limited to their taxonomic description. The strain AR92, previously identified as belonging to the genus Cohnella, formed a well-supported cluster with C. thailandensis and C. formosensis (>80% bootstrap confidence). Its growth and xylanase production were approached by using a mineral-based medium containing alkali-pretreated sugarcane bagasse as the main carbon source, which was assayed as a convenient source to produce biocatalysts potentially fitting its degradation...
November 23, 2017: Journal of Molecular Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29165436/cochlear-implant-in-prelingually-deafened-oralist-adults-speech-perception-outcomes-subjective-benefits-and-quality-of-life-improvement
#9
F Forli, G Turchetti, G Giuntini, S Bellelli, S Fortunato, L Bruschini, M R Barillari, S Berrettini
The aim of this study is to report our results in a group of prelingually deafened adults, who followed an oralist rehabilitation programme, and submitted to cochlear implant at our institution. We evaluated 30 prelingually deafened adult patients, 18 males and 12 females, median age 35 years, of a group of 36 prelingually deafened adult patients consecutively submitted to unilateral cochlear implantation at the ENT Unit of the University of Pisa. After implantation, patients achieved significant benefits in terms of speech perception skills, including the ability to have telephone conversations in some cases, quality of life and their own perception of disability...
October 2017: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/29160956/photosensitization-of-molecular-oxygen-on-graphene-oxide-for-ultrasensitive-signal-amplification
#10
Xinfeng Zhang, Li Deng, Chengpeng Huang, Jinyi Zhang, Xiandeng Hou, Peng Wu, Juewen Liu
H2O2 and horseradish peroxidase (HRP) are commonly used together in bioassays. HRP is required to accelerate the reaction between a chromogenic substrate (e.g., 3,3',5,5'-tetramethylbenzidine, TMB) and H2O2 and thus amplifies the signal. We herein explore molecular oxygen for enzyme-free and H2O2-free oxidation, while still using the same colorimetric reaction. Restricted by spin selection rules, the ground-state triplet oxygen needs to be converted to the singlet state to oxide TMB. We used phloxine B (PB) as the photosensitizer for its excellent performance and safety...
November 21, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29160874/biofilm-dispersal-using-nitric-oxide-loaded-nanoparticles-fabricated-by-photo-pisa-influence-of-morphology
#11
Zahra Sadrearhami, Jonathan Yeow, Thuy-Khanh Nguyen, Kitty K K Ho, Naresh Kumar, Cyrille Boyer
Polymeric nanoparticles (NPs) of different morphologies (spheres and worms) were synthesized using a visible light mediated polymerization-induced self-assembly (PISA) approach. Spherical and worm-like NPs were subsequently modified to generate diazeniumdiolate functionalized NPs. Interestingly, the NO release rate and the dispersal of biofilms were found to strongly depend on the NP morphology. NPs with a higher aspect ratio (worms) exhibited a slower NO release rate and greater biofilm dispersal after 1 h of incubation...
November 21, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29160148/are-pupils-programme-for-international-student-assessment-pisa-scores-associated-with-a-nation-s-fish-consumption
#12
Volker Schmiedel, Hans Vogt, Harald Walach
AIMS: Omega-3 fatty acids are essential for neurodevelopment. Fish is a major source of these essential nutrients. We asked whether a nation's fish consumption is associated with its pupils' PISA scores as measures of school achievement, independent of economic status and breastfeeding. Method (Design and Setting): This was a regression analytic study based on published data. RESULTS: Data on fish consumption and PISA scores were available for 64 countries. A significant regression model explained 72% of the variance in PISA scores...
July 1, 2017: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/29151099/camptocormia-new-signs-in-an-old-syndrome
#13
Laurent Tatu, Julien Bogousslavsky
Camptocormia is defined as an involuntary flexion of the thoracolumbar spine, without fixed kyphosis, which increases during walking and standing, and abates in the supine position. First described during World War 1 in soldiers suffering from war psychoneuroses, camptocormia has progressively come to refer to any cause of trunk forward-flexed posture during standing and ambulation. It is now admitted that camptocormia should be considered as a syndrome related to many etiologies. In this chapter, we present the historical aspects of the syndrome and its main etiologies...
2018: Frontiers of Neurology and Neuroscience
https://www.readbyqxmd.com/read/29148796/layer-by-layer-self-assembly-of-polyelectrolytic-block-copolymer-worms-on-a-planar-substrate
#14
Nicholas Penfold, Andrew J Parnell, Marta Molina, Pierre Verstraete, Johan Smets, Steven P Armes
Cationic and anionic block copolymer worms are prepared by polymerization-induced self-assembly (PISA) via reversible addition-fragmentation chain transfer (RAFT) aqueous dispersion copolymerization of 2-hydroxypropyl methacrylate (HPMA) and glycidyl methacrylate (GlyMA), using a binary mixture of a non-ionic poly(ethylene oxide) (PEO) macromolecular RAFT agent and either a cationic poly([2-(methacryloyloxy)ethyl] trimethylammonium chloride) (PQDMA) or an anionic poly(potassium 3-sulfopropyl methacrylate) (PKSPMA) macromolecular RAFT agent...
November 17, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29142087/no-evidence-of-disease-activity-is-associated-with-reduced-rate-of-axonal-retinal-atrophy-in-ms
#15
Marco Pisa, Simone Guerrieri, Giovanni Di Maggio, Stefania Medaglini, Lucia Moiola, Vittorio Martinelli, Giancarlo Comi, Letizia Leocani
OBJECTIVE: To explore, in a longitudinal study, the usefulness of optical coherence tomography (OCT) in monitoring people with multiple sclerosis (MS) by testing the association between retinal nerve fiber layer (RNFL) thinning and clinical and brain MRI criteria of no evidence of disease activity (NEDA). METHODS: OCT, visual evoked potentials (VEPs), and disability, using the Expanded Disability Status Scale (EDSS), were tested at baseline and after 2 years in 72 patients, 63 with routine yearly brain MRI...
November 15, 2017: Neurology
https://www.readbyqxmd.com/read/29134507/prevalence-and-characteristics-of-orthorexia-nervosa-in-a-sample-of-university-students-in-italy
#16
L Dell'Osso, Barbara Carpita, D Muti, I M Cremone, G Massimetti, E Diadema, C Gesi, C Carmassi
AIMS: Orthorexia nervosa (ON) has been recently defined as a pathological approach to feeding related to healthiness concerns and purity of food and/or feeding habits. This condition recently showed an increasing prevalence particularly among young adults. In order to investigate the prevalence of ON and its relationship with gender and nutritional style among young adults, we explored a sample of students from the University of Pisa, Italy. METHODS: Assessments included the ORTO-15 questionnaire and a socio-demographic and eating habits form...
November 13, 2017: Eating and Weight Disorders: EWD
https://www.readbyqxmd.com/read/29129119/periodontal-inflamed-surface-area-and-periodontal-case-definition-classification
#17
Yago Leira, Pablo Martín-Lancharro, Juan Blanco
OBJECTIVE: To assess whether a higher periodontal inflamed surface area (PISA) may reflect more severe periodontitis, and if so, to calculate which cut-off point should be used to classify a patient as suffering from periodontitis. MATERIAL AND METHODS: Eighty subjects were selected based on their periodontal status and were divided into 4 groups of 20 each; periodontally healthy, mild periodontitis, moderate periodontitis and severe periodontitis. In addition, demographic data, smoking status and socioeconomic status were also recorded...
November 11, 2017: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/29124633/an-update-of-the-worldwide-integrated-assessment-wia-on-systemic-insecticides-part-2-impacts-on-organisms-and-ecosystems
#18
Lennard Pisa, Dave Goulson, En-Cheng Yang, David Gibbons, Francisco Sánchez-Bayo, Edward Mitchell, Alexandre Aebi, Jeroen van der Sluijs, Chris J K MacQuarrie, Chiara Giorio, Elizabeth Yim Long, Melanie McField, Maarten Bijleveld van Lexmond, Jean-Marc Bonmatin
New information on the lethal and sublethal effects of neonicotinoids and fipronil on organisms is presented in this review, complementing the previous Worldwide Integrated Assessment (WIA) in 2015. The high toxicity of these systemic insecticides to invertebrates has been confirmed and expanded to include more species and compounds. Most of the recent research has focused on bees and the sublethal and ecological impacts these insecticides have on pollinators. Toxic effects on other invertebrate taxa also covered predatory and parasitoid natural enemies and aquatic arthropods...
November 9, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29119798/a-very-low-dose-of-rivastigmine-induced-pisa-syndrome-in-a-clozapine-treated-patient
#19
Pei-Chun Chao, Juo-Chi Li, Ta-Chuan Yeh, Chin-Bin Yeh
No abstract text is available yet for this article.
November 1, 2017: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/29117366/2017-pathobiology-for-investigators-students-and-academicians-pisa-meeting
#20
(no author information available yet)
No abstract text is available yet for this article.
December 1, 2017: Glycobiology
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