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Gianpiero Manca, Federico Davini, Elisa Tardelli, Annalisa De Liperi, Fabio Falaschi, Franca Melfi, Patrick M Colletti, Domenico Rubello, Duccio Volterrani, Giuseppe Boni
PURPOSE: Incidental solitary pulmonary nodules (SPNs) have become an increasingly common CT finding worldwide. Although there are currently many imaging strategies for evaluating SPNs, the differential diagnosis and management of SPNs remains complex because of overlap between benign and malignant processes. Moreover, transbronchial or percutaneous CT-guided biopsies do not always allow definitive diagnoses. In such cases, video-assisted thoracic surgery (VATS) has become the preferred surgical procedure for diagnosis and, in selected cases, for treatment of indeterminate SPNs...
February 9, 2018: Clinical Nuclear Medicine
T L Leighton, M C Mok, M S Junop, P L Howell, L L Burrows
Pseudomonas aeruginosa uses long, thin fibres called type IV pili (T4P) for adherence to surfaces, biofilm formation, and twitching motility. A conserved subcomplex of PilMNOP is required for extension and retraction of T4P. To better understand its function, we attempted to co-crystallize the soluble periplasmic portions of PilNOP, using reductive surface methylation to promote crystal formation. Only PilOΔ109 crystallized; its structure was determined to 1.7 Å resolution using molecular replacement. This new structure revealed two novel features: a shorter N-terminal α1-helix followed by a longer unstructured loop, and a discontinuous β-strand in the second αββ motif, mirroring that in the first motif...
February 8, 2018: Scientific Reports
Hiroyuki Toda, Takeshi Inoue, Masaaki Tanichi, Taku Saito, Shin Nakagawa, Jiro Masuya, Hajime Tanabe, Aihide Yoshino, Ichiro Kusumi
In previous studies, various components such as environmental and genetic factors have been shown to contribute to the development of bipolar disorder (BD). This study investigated how multiple factors, including child abuse, adult life events, and affective temperaments, are interrelated and how they affect the diagnosis of BD. A total of 170 healthy controls and 75 BD patients completed the following self-administered questionnaires: the Patient Health Questionnaire-9 evaluating the severity of depressive symptoms; the Child Abuse and Trauma Scale (CATS) evaluating child abuse; the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego autoquestionnaire (TEMPS-A) evaluating affective temperaments; and the Life Experiences Survey (LES) evaluating negative and positive adult life events...
January 29, 2018: Psychiatry Research
Luisa Weiner, Sébastien Weibel, Wagner de Sousa Gurgel, Ineke Keizer, Marianne Gex-Fabry, Anne Giersch, Gilles Bertschy
Racing thoughts refer to an acceleration and overproduction of thoughts, which have been associated with manic and mixed episodes. Phenomenology distinguishes 'crowded' from 'racing' thoughts, associated with mixed depression and mania, respectively. Recent data suggest racing thoughts might also be present in healthy individuals with sub-affective traits and symptoms. We investigated this assumption, with a 34-item self-rating scale, the Racing and Crowded Thoughts Questionnaire (RCTQ), and evaluated its reliability, factor structure, and concurrent validity...
January 26, 2018: Comprehensive Psychiatry
Matteo Caloro, Giuseppa Calabrò, Eleonora de Pisa, Enrico Rosini, Georgios D Kotzalidis, Davide Lonati, Carlo Alessandro Locatelli, Pietro Papa, Fabrizio Schifano, Paolo Girardi
: Novel psychoactive substance use is a major social concern. Their use may elicit or uncover unpredictably as yet undescribed clinical pictures. We aimed to illustrate a multisubstance use case indistinguishable from paranoid schizophrenia, so to alert clinicians on possibly misdiagnosing substance-induced psychotic disorders. CASE REPORT: We describe a case of a 32-year-old man who started at 18 years with cannabinoids and ketamine, and is currently using N-methyl-D-aspartate (NMDA) antagonists...
February 2, 2018: Journal of Addiction Medicine
Meng Huo, Dan Li, Guangjie Song, Jun Zhang, Decheng Wu, Yen Wei, Jinying Yuan
A series of polymerization-induced self-assembly (PISA) formulations are developed based on reversible addition-fragmentation chain-transfer (RAFT) dispersion polymerization of semi-fluorinated methacrylates. Alcoholic RAFT dispersion polymerization of 2-(perfluorobutyl)ethyl methacrylate (FBEMA), 2-(perfluorohexyl)ethyl methacrylate (FHEMA), and 2-(perfluorooctyl)ethyl methacrylate (FOEMA) is systematically evaluated to extend the general usability of semi-fluorinated methacrylates to PISA. The nanostructure of the assemblies is correlated to the side-chain length of the monomer: RAFT dispersion polymerization of FBEMA produces spherical micelles, wormlike micelles, and vesicles depending on its degree of polymerization (DP), while only spheres are generated for the PISA of FHEMA...
February 5, 2018: Macromolecular Rapid Communications
Fabio Galbusera, Tito Bassani, Elena Stucovitz, Carlotta Martini, Maryem-Fama Ismael Aguirre, Pedro L Berjano, C Lamartina
PURPOSE: Most patients suffering from Parkinson's disease (PD) exhibit alterations in the posture, which can in several cases give rise to spine deformities, both in the sagittal and the coronal plane. In addition, degenerative disorders of the spine frequently associated to PD, such as spinal stenosis and sagittal instability, can further impact the quality of life of the patient. In recent years, spine surgery has been increasingly performed, with mixed results. The aim of this narrative review is to analyze the spinal disorders associated to PD, and the current evidence about their surgical treatment...
February 3, 2018: European Spine Journal
Isabel L Dittmann, Thomas Zauchner, Lucy M Nevard, Maximilian J Telford, Bernhard Egger
Acoel worms are simple, often microscopic animals with direct development, a multiciliated epidermis, a statocyst, and a digestive parenchyma instead of a gut epithelium. Morphological characters of acoels have been notoriously difficult to interpret due to their relative scarcity. The nervous system is one of the most accessible and widely used comparative features in acoels, which have a so-called commissural brain without capsule and several major longitudinal neurite bundles. Here, we use the selective binding properties of a neuropeptide antibody raised in echinoderms (SALMFamide2, or S2), and a commercial antibody against serotonin (5-HT) to provide additional characters of the acoel nervous system...
February 1, 2018: Journal of Morphology
Modiehi Heather Sedibe, Pedro T Pisa, Alison B Feeley, Titilola M Pedro, Kathleen Kahn, Shane A Norris
The aim of this study was to investigate differences/similarities in dietary habits and eating practices between younger and older, rural and urban South African adolescents in specific environments (home, community and school) and their associations with overweight and obesity. Dietary habits, eating practices, and anthropometric measurements were performed on rural (n = 392, mean age = 13 years) and urban (n = 3098, mean age = 14 years) adolescents. Logistic regression analysis was used to examine the associations between dietary habits and eating practices, with overweight and obesity risk...
January 29, 2018: Nutrients
Young Eun Huh, Kunhyun Kim, Won-Ho Chung, Jinyoung Youn, Seonwoo Kim, Jin Whan Cho
We elucidated whether verticality misperception is associated with the generation of Pisa syndrome (PS) in patients with Parkinson's disease (PD). To examine the heterogenous influence of verticality perception, we also identified the characteristics distinguishing between PD patients with PS who tilted toward the deviation of perceived verticality and those who did not. Subjective visual vertical (SVV) testing was performed in 54 PD patients with PS and 36 without PS to measure verticality perception. Other potential risk factors for PS were evaluated by assessing the asymmetry of motor symptoms, EMG activities of paraspinal muscles, bithermal caloric tests, back pain history, and Berg Balance Scale...
January 29, 2018: Scientific Reports
Linda A Russell, Alana E Sigmund, Jackie Szymonifka, Shari T Jawetz, Sarah E Grond, Shirin A Dey, Anne R Bass
The diagnosis of venous thromboembolism is difficult in the postoperative setting because signs such as hypoxemia, leg pain, and swelling are so common. CTPA can also detect subsegmental PE (SSPE), of which the clinical significance has been widely debated. Clinical decision rules (CDR), such as the Wells and PISA 2, have been developed to identify symptomatic patients at low risk for PE who could forgo imaging. We performed this study in order to (1) compare the performance of the Wells and PISA 2 CDR in orthopedic patients; (2) compare CDR scores in patients with subsegmental PE (SSPE) versus larger clots; and (3) identify variables that improve performance of the Wells in orthopedic patients...
January 25, 2018: Journal of Thrombosis and Thrombolysis
Lisa Epping, Wolfgang Miesbach, Katrin Nickles, Peter Eickholz
BACKGROUND: Von Willebrand disease (VWD) is the most common inherent bleeding disorder. Gingival bleeding is a frequently reported symptom of VWD. However, gingival bleeding is also a leading symptom of plaque-induced gingivitis and untreated periodontal disease. In type 1 VWD gingival bleeding was not increased compared to controls. Thus, this study evaluated whether type 2 and 3 VWD determines an increased susceptibility to gingival bleeding in response to the oral biofilm. METHODS: Twenty-four cases and 24 controls matched for age, sex, periodontal diagnosis, number of teeth and smoking were examined hematologically (VWF antigen, VWF activity, factor VIII activity) and periodontally (Gingival Bleeding Index [GBI]), bleeding on probing [BOP], Plaque Control Record [PCR], periodontal inflamed surface area [PISA], vertical probing attachment level)...
2018: PloS One
Masha Y Ivanova, Thomas M Achenbach, Leslie A Rescorla, Jiesi Guo, Robert R Althoff, Kees-Jan Kan, Fredrik Almqvist, Ivan Begovac, Anders G Broberg, Myriam Chahed, Marina Monzani da Rocha, Anca Dobrean, Manfred Döepfner, Nese Erol, Eric Fombonne, Antonio Castro Fonseca, Maria Forns, Alessandra Frigerio, Hans Grietens, Nohelia Hewitt-Ramirez, Fernando Juarez, Ilona Kajokienė, Yasuko Kanbayashi, Young-Ah Kim, Bo Larsson, Patrick Leung, Xianchen Liu, Alfio Maggiolini, Asghar Minaei, Paulo A S Moreira, Kyung Ja Oh, Djaouida Petot, Cecilia Pisa, Rolando Pomalima, Alexandra Roussos, Vlasta Rudan, Michael Sawyer, Mimoza Shahini, Edwiges Ferreira de Mattos Silvares, Zeynep Simsek, Hans-Christoph Steinhausen, Lajos Szirovicza, Jose Valverde, Laura Viola, Sheila Weintraub, Christa Winkler Metzke, Tomasz Wolanczyk, Bernardine Woo, Eugene Yuqing Zhang, Nelly Zilber, Rita Žukauskienė, Frank C Verhulst
As societies become increasingly diverse, mental health professionals need instruments for assessing emotional, behavioral, and social problems in terms of constructs that are supported within and across societies. Building on decades of research findings, multisample alignment confirmatory factor analyses tested an empirically based 8-syndrome model on parent ratings across 30 societies and youth self-ratings across 19 societies. The Child Behavior Checklist for Ages 6-18 and Youth Self-Report for Ages 11-18 were used to measure syndromes descriptively designated as Anxious/Depressed, Withdrawn/Depressed, Somatic Complaints, Social Problems, Thought Problems, Attention Problems, Rule-Breaking Behavior, and Aggressive Behavior...
January 24, 2018: Journal of Clinical Child and Adolescent Psychology
Fabio Salvatore Macaluso, Chiara Sapienza, Marco Ventimiglia, Sara Renna, Giulia Rizzuto, Rosalba Orlando, Marta Di Pisa, Marco Affronti, Emanuele Orlando, Mario Cottone, Ambrogio Orlando
Background: The addition of an immunosuppressant (IM) after loss of response to anti-TNFα monotherapy is an emerging strategy of therapeutic optimization in patients with inflammatory bowel disease (IBD). However, few clinical data have been reported to date. We aimed to evaluate the efficacy and safety of this selective combination therapy in patients with IBD. Methods: All consecutive patients with loss of response to anti-TNFα monotherapy despite an intensive dose optimization who added an IM from October 2014 to October 2016 were entered into a prospective database...
January 18, 2018: Inflammatory Bowel Diseases
Alessandro Lunardi, Rosa Cervelli, Duccio Volterrani, Saverio Vitali, Carlo Lombardo, Giulia Lorenzoni, Laura Crocetti, Irene Bargellini, Daniela Campani, Luca Emanuele Pollina, Roberto Cioni, Davide Caramella, Ugo Boggi
PURPOSE: To assess the feasibility of radiological stage-1 ALPPS, associating liver partition and portal vein ligation for staged hepatectomy, by combining portal vein embolization (PVE) with percutaneous intrahepatic split by ablation (PISA). MATERIALS AND METHODS: Three patients (mean age 65.0 ± 7.3 years) underwent PVE and PISA. PISA was performed 21 days after PVE by microwave ablation to create a continuous intrahepatic cutting plane. Abdominal CT examinations were performed before and after PVE and PISA...
January 22, 2018: Cardiovascular and Interventional Radiology
Fahimeh Khakzad, Ali Reza Mahdavian, Hamid Salehi-Mobarakeh, Mohammad Hossain Sharifian
HYPOTHESIS: Surfactant-free emulsion polymerization has become favorable due to circumventing instability issues reasonably. Incorporation of an appropriate hydrophilic macroRAFT, could provide controlled in-situ self-assembly via copolymerization with hydrophobic monomers into polymer particles. So far, this approach has mostly been studied in dispersion systems and further studies are needed in emulsions. Beside the corresponding mechanistic studies, the prepared latex particles would potentially exhibit smart behaviors by choosing stimuli-responsive monomers...
January 4, 2018: Journal of Colloid and Interface Science
Giuseppe Cullaro, Joseph F Pisa, Robert S Brown, Gebhard Wagener, Elizabeth C Verna
BACKGROUND: Urinary NGAL (uNGAL)-associated acute kidney injury (AKI) is common following liver transplant (LT), but whether early AKI predicts chronic kidney disease (CKD) and mortality remains uncertain. METHODS: Adults with LT from 2008-2010 in a previously published prospective cohort evaluating serial uNGAL pre- and post-LT were retrospectively assessed to evaluate uNGAL as a predictor of long-term outcomes post-LT. The primary outcomes were post-LT CKD, defined as MDRD estimated glomerular filtration rate (GFR)<60 mL/min/1...
January 3, 2018: Transplantation
Bertram Unger, Nariman Sepehri, Vivek Rampersad, Justyn Pisa, Michael Gousseau, Jordan B Hochman
Background: Temporal bone simulations are critiqued for poor drill-bone interaction. This project appraises the import of increasing haptic device and manipulandum fidelity on the perceived realism of drilling a virtual temporal bone.Virtual surgical contact forces rely on haptic device fidelity and are transmitted through a manipulandum. With identical software, both device hardware and manipulandum may each contribute to realism. We compare the three degrees of freedom (DOF), 3N Geomagic Touch (3D Systems, SC) to a 6DOF, 5...
December 2017: Laryngoscope Investigative Otolaryngology
Sanjay Pandey, Laxmikant Ramkumarsingh Tomar, Priyanka Tater
No abstract text is available yet for this article.
January 2, 2018: JAMA Neurology
Masanao Shirahama, Takeshi Terao, Nobuyoshi Ishii, Koji Hatano, Hirofumi Hirakawa, Kentaro Kohno
AIMS: In order to resolve the equivocal relationship between anxious temperament rated by the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego Auto-questionnaire (TEMPS-A) and harm avoidance rated by the Temperament and Character Inventory (TCI), the present study aims to investigate whether the anxious temperament scale and the harm avoidance scale are significantly associated with adjustment of relevant factors. Our hypothesis is that anxious temperament may be associated with harm avoidance...
December 29, 2017: Psychiatry and Clinical Neurosciences
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