Xinwei Zhao, Tao Hou, Han Zhou, Ziling Liu, Yanfang Liu, Chaoran Wang, Zhimou Guo, Dongping Yu, Qing Xu, Jixia Wang, Xinmiao Liang
Insomnia is a common and refractory disease. Since more than 2000 years ago, people have been using Ziziphi Spinosae Semen (ZSS). However, there are lack of molecular mechanisms of sleep promotion effects of ZSS. The purpose of this study is to clarify the active ingredients in ZSS that are used to treat insomnia. Using a method called cellular label-free integrative pharmacology (CLIP), we established five insomnia-related target models, including serotonin (5HT2A and 5HT1A ), melatonin (MT1 ), dopamine (D2 ) and epinephrine (β2 ) receptors...
October 24, 2023: Fitoterapia