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https://www.readbyqxmd.com/read/28329258/a-new-frailty-score-for-experimental-animals-based-on-the-clinical-phenotype-inactivity-as-a-model-of-frailty
#1
Mari Carmen Gomez-Cabrera, Rebeca Garcia-Valles, Leocadio Rodriguez-Mañas, Francisco Jose Garcia-Garcia, Gloria Olaso-Gonzalez, Andrea Salvador-Pascual, Francisco Jose Tarazona-Santabalbina, Jose Viña
The development of animal models to study human frailty is important to test interventions to be translated to the clinical practice. The aim of this work was to develop a score for frailty in experimental animals based in the human frailty phenotype. We also tested the effect of physical inactivity in the development of frailty as determined by our score. Male C57Bl/6J mice, individually caged, were randomly assigned to one of two groups: sedentary (inactive) or spontaneous wheel-runners. We compared the sedentary versus the active lifestyle in terms of frailty by evaluating the clinical criteria used in humans: unintentional weight loss; poor endurance (running time); slowness (running speed); weakness (grip strength), and low activity level (motor coordination) at five different ages: 17, 20, 23, 26 and 28 months of age...
January 19, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28328839/association-between-physical-activity-sedentary-behavior-and-fitness-with-health-related-quality-of-life-in-healthy-children-and-adolescents-a-protocol-for-a-systematic-review-and-meta-analysis
#2
Alberto Bermejo-Cantarero, Celia Álvarez-Bueno, Vicente Martinez-Vizcaino, Antonio García-Hermoso, Ana Isabel Torres-Costoso, Mairena Sánchez-López
BACKGROUND: Health related quality of life (HRQoL) is a subjective, multidimensional and changing over time construct. When HRQoL is decreased, a child is less likely to be able to develop normally and mature into a healthy adult. Physical inactivity is a priority public health problem. Evidence suggests how even moderate levels of physical activity or high fitness levels are associated with benefits for the health in children and adolescents. The aims of this systematic review are to examine the evidence about the relationship between physical activity, sedentary behavior, and fitness with HRQoL, and estimate the effects of interventions that have tested the effectiveness of the increase of the physical activity, the improvement of the physical fitness or the avoidance of sedentary behaviors in HRQoL in healthy subjects aged under 18 years old...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28328269/physical-activity-and-exercise-after-stoma-surgery-overcoming-the-barriers
#3
Sarah Russell
This article presents the results from a large nationwide survey completed in 2016 that investigated the physical health and wellbeing of people living with stomas in the UK. In particular, the survey looked at physical activity and exercise, general attitudes and opinions about exercise, whether or not advice about physical activity had been received and other general questions about parastomal hernia and quality of life. There were 2631 respondents making it one of the largest known surveys to date. The findings were concerning yet unsurprising, highlighting a trend toward inactivity after stoma surgery and a fear of exercise in general...
March 9, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/28327831/-assessment-of-the-nutritional-status-physical-activity-and-eating-habits-of-schoolchildren-in-cercado-de-lima
#4
Juan Pablo Aparco, William Bautista-Olórtegui, Laura Astete-Robilliard, Jenny Pillaca
Objectives: To assess the nutritional status, physical activity, and eating habits of schoolchildren in Cercado de Lima (Lima district). Materials and methods: Cross-sectional descriptive study. The sample included schoolchildren from first to fourth grade in four public elementary schools located in Cercado de Lima. The study variables were nutritional status, hemoglobin dose, physical activity, and eating habits. The percentages of the qualitative variables and central tendency measures for quantitative ones were calculated...
October 2016: Revista Peruana de Medicina Experimental y Salud Pública
https://www.readbyqxmd.com/read/28325517/post-traumatic-stress-disorder-and-20-year-physical-activity-trends-among-women
#5
Ashley Winning, Paola Gilsanz, Karestan C Koenen, Andrea L Roberts, Qixuan Chen, Jennifer A Sumner, Eric B Rimm, M Maria Glymour, Laura D Kubzansky
INTRODUCTION: Post-traumatic stress disorder (PTSD) may be associated with physical inactivity, a modifiable lifestyle factor that contributes to risk of cardiovascular and other chronic diseases; however, no study has evaluated the association between PTSD onset and subsequent physical activity (PA) changes. METHOD: Analyses were conducted between October 2014 and April 2016, using data from the ongoing Nurses' Health Study II (N=50,327). Trauma exposure and PTSD symptoms were assessed using two previously validated measures, the Brief Trauma Questionnaire and Short Screening Scale for DSM-IV PTSD...
March 18, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28322530/-stima-dei-decessi-per-tumori-attribuibili-a-fattori-di-rischio-comportamentali-in-italia-nel-2013
#6
Francesca Battisti, Giulia Carreras, Tommaso Grassi, Elisabetta Chellini, Giuseppe Gorini
"Non-communicable diseases cause more than 80% of deaths in europe and, among these, 20% are caused by cancer. Modifiable lifestyle factors considered in the italian national programme "Guadagnare salute" (Gaining health), such as tobacco smoking, unhealthy diet, physical inactivity, overweight, and excessive alcohol use, are amongst the major causes of cancer deaths. The aims of this study was to estimate the number of deaths attributable to lifestyle factors for italy and for italian regions in 2013 and to describe its variation in relation to the regional prevalence of risk factors exposure...
January 2017: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/28320732/what-is-the-effect-of-health-coaching-on-physical-activity-participation-in-people-aged-60-years-and-over-a-systematic-review-of-randomised-controlled-trials
#7
REVIEW
Juliana S Oliveira, Catherine Sherrington, Anita B Amorim, Amabile B Dario, Anne Tiedemann
BACKGROUND: Physical inactivity is common in older age, yet increased activity benefits older people in terms of preventing chronic disease and maximising independence. Health coaching is a behaviour change intervention that has been shown to increase physical activity in clinical populations. This systematic review and meta-analysis investigated the effect of health coaching on physical activity, mobility, quality of life and mood in older people. METHODS: MEDLINE, EMBASE, CENTRAL, PsycINFO, PEDro, SPORTDiscus, LILACS and CINAHL databases were used to identify randomised controlled trials which evaluated the effect of health coaching on physical activity (primary outcome) among people aged 60+...
March 20, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28320409/can-an-incentive-based-intervention-increase-physical-activity-and-reduce-sitting-among-adults-the-achieve-active-choices-incentive-feasibility-study
#8
Kylie Ball, Ruth F Hunter, Jaimie-Lee Maple, Marj Moodie, Jo Salmon, Kok-Leong Ong, Lena D Stephens, Michelle Jackson, David Crawford
BACKGROUND: Despite recent interest in the potential of incentivisation as a strategy for motivating healthier behaviors, little remains known about the effectiveness of incentives in promoting physical activity and reducing sedentary behavior, and improving associated health outcomes. This pre-post-test design study investigated the feasibility, appeal and effects of providing non-financial incentives for promoting increased physical activity, reduced sedentary time, and reduced body mass index (BMI) and blood pressure among inactive middle-aged adults...
March 21, 2017: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/28320046/increased-insulin-resistance-and-glucagon-levels-in-mild-inactive-systemic-lupus-patients-despite-normal-glucose-tolerance
#9
Cíntia Nh Miyake, Bruno Gualano, Wagner S Dantas, Renato T Pereira, William Neves, Vanessa O Zambelli, Samuel K Shinjo, Rosa M Pereira, Elizabeth R Silva, Ana Lúcia Sá-Pinto, Eduardo Borba, Hamilton Roschel, Eloisa Bonfá, Fabiana B Benatti
OBJECTIVE: To assess insulin sensitivity in patients with systemic lupus erythematosus (SLE) in response to a meal tolerance test (MTT). METHODS: In this cross-sectional study, 33 adult females mild/inactive SLE and 16 age- and body mass index (BMI)-matched female healthy controls (CTRL) underwent a MTT and were assessed for insulin sensitivity and beta-cell function. Skeletal muscle protein expressions of total and membrane GLUT-4 were also evaluated (SLE, n=10; CTRL, n=5); muscle biopsies were performed after MTT...
March 20, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28316789/reliability-and-concurrent-validity-of-the-international-physical-activity-questionnaire-short-form-among-pregnant-women
#10
Birgitte Sanda, Ingvild Vistad, Lene Annette Hagen Haakstad, Sveinung Berntsen, Linda Reme Sagedal, Hilde Lohne-Seiler, Monica Klungland Torstveit
ABSTRACT: Sanda B, Vistad I, Haakstad LAH, Berntsen S, Sagedal LR, Lohne-Seiler H, Torstveit MK. Reliability and concurrent validity of the International Physical Activity Questionnaire short form among pregnant women. BACKGROUND: The International Physical Activity Questionnaire short-form (IPAQ-SF) is frequently used to assess physical activity (PA) level in the general adult population including pregnant women. However, the reliability and validity of the questionnaire in pregnancy is unknown...
2017: BMC Sports Science, Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28314794/the-microtubule-associated-protein-map18-affects-rop2-gtpase-activity-during-root-hair-growth
#11
Erfang Kang, Mingzhi Zheng, Yan Zhang, Ming Yuan, Shaul Yalovsky, Lei Zhu, Ying Fu
Establishment and maintenance of the polar site are important for root hair tip growth. We previously reported that Arabidopsis (Arabidopsis thaliana) MICROTUBULE-ASSOCIATED PROTEIN18 (MAP18) functions in controlling the direction of pollen tube growth and root hair elongation. Additionally, the Rop GTPase ROP2 was reported as a positive regulator of both root hair initiation and tip growth in Arabidopsis. Both loss-of-function of ROP2 or knock-down of MAP18 leads to a decrease in root hair length, whereas overexpression of either MAP18 or ROP2 causes multiple tips or a branching hair phenotype...
March 17, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28303253/design-implementation-and-study-protocol-of-a-kindergarten-based-health-promotion-intervention
#12
Susanne Kobel, Olivia Wartha, Tamara Wirt, Jens Dreyhaupt, Christine Lämmle, Eva-Maria Friedemann, Anne Kelso, Claire Kutzner, Lina Hermeling, Jürgen M Steinacker
Inactivity and an unhealthy diet amongst others have led to an increased prevalence of overweight and obesity even in young children. Since most health behaviours develop during childhood health promotion has to start early. The setting kindergarten has been shown as ideal for such interventions. "Join the Healthy Boat" is a kindergarten-based health promotion programme with a cluster-randomised study focussing on increased physical activity, reduced screen media use, and sugar-sweetened beverages, as well as a higher fruit and vegetable intake...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28302102/insomnia-symptoms-as-a-cause-of-type-2-diabetes-incidence-a-20%C3%A2-year-cohort-study
#13
Michael J Green, Colin A Espie, Frank Popham, Tony Robertson, Michaela Benzeval
BACKGROUND: Insomnia symptoms are associated with type 2 diabetes incidence but are also associated with a range of potential time-varying covariates which may confound and/or mediate associations. We aimed to assess whether cumulative exposure to insomnia symptoms has a causal effect on type 2 diabetes incidence. METHODS: A prospective cohort study in the West of Scotland, following respondents for 20 years from age 36. 996 respondents were free of diabetes at baseline and had valid data from up to four follow-up visits...
March 16, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28302047/neuroinflammation-as-a-common-mechanism-associated-with-the-modifiable-risk-factors-for-alzheimer-s-and-parkinson-s-diseases
#14
Jordan Alexander McKenzie, Lindsay J Spielman, Caitlin B Pointer, Jessica R Lowry, Ekta Bajwa, Carolyn W Lee, Andis Klegeris
Alzheimer's disease (AD) and Parkinson's disease (PD) are among the most common causes of dementia, which increasingly contribute to morbidity and mortality worldwide. A common hallmark in the pathogenesis of these two diseases is neuroinflammation, which is initially triggered by the presence of pathological structures associated with these disorders. Chronic neuroinflammation is sustained by persistent and aberrant microglial activation in the brain, which results in damage and death of neighboring cells, including neurons and glial cells...
March 15, 2017: Current Aging Science
https://www.readbyqxmd.com/read/28299032/demographic-and-life-styles-determinants-of-somatic-complaints-structures-a-cross-sectional-study-on-a-large-sample-of-iranian-adults-using-factor-mixture-model
#15
Zahra Heidari, Awat Feizi, Hamidreza Roohafza, Ammar Hassanzadeh Keshteli, Fatemeh Zahra Shiravi, Payman Adibi
BACKGROUND: To identify somatic complaints dimensions, classify studied population and study the association of demographic and lifestyle factors with somatic complaints dimensions. METHODS: In a cross-sectional study conducted on 4763 Iranian adults, somatic complaints were assessed using a comprehensive 30-item questionnaire. Self-administered standard questionnaires were used to assess demographic and lifestyle factors. Factor mixture modeling (FMM) was used to identify somatic complaints dimensions and classify studied population...
2017: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28298332/impact-of-lifelong-exercise-training-on-endothelial-ischemia-reperfusion-and-ischemic-preconditioning-in-humans
#16
Martijn F H Maessen, Anke Ccm van Mil, Yaïra Straathof, Niels P Riksen, Gerard A P J M Rongen, Maria T E Hopman, Thijs M H Eijsvogels, Dick H J Thijssen
Reperfusion is essential for ischemic tissue survival, but causes additional damage to the endothelium (i.e. ischemia-reperfusion [IR] injury). Ischemic preconditioning (IPC) refers to short repetitive episodes of ischemia that can protect against IR. However, IPC efficacy attenuates with older age. Whether physical inactivity contributes to the attenuated efficacy of IPC to protect against IR injury in older humans is unclear. We tested the hypotheses that lifelong exercise training relates to 1) attenuated endothelial IR and 2) maintained IPC efficacy that protects veteran athletes against endothelial IR...
March 15, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28293879/construction-of-protein-switches-by-domain-insertion-and-directed-evolution
#17
Lucas F Ribeiro, Tiana D Warren, Marc Ostermeier
A protein switch is a protein that changes between inactive ("off") and active ("on") states in response to a biomolecule or physical signal. These switches can be created by fusing two domains in such a way that the activity of the output domain is regulated by the input domain's recognition of an input signal (such as the binding of a molecule, recognition of light). Here, we describe several methods for randomly fusing two domains to create domain insertion libraries from which protein switches can be identified by selections and/or screens...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28293621/development-of-the-physical-activity-and-your-nutrition-for-cancer-pync-smartphone-app-for-preventing-breast-cancer-in-women
#18
Steven S Coughlin, Gina M Besenyi, Deborah Bowen, Gianluca De Leo
BACKGROUND: In the U.S., breast cancer accounts for more cancer deaths in women than any site other than lung cancer. Based upon attributable risks, about 30-35% of breast cancers could potentially be prevented by addressing obesity, physical inactivity, increased alcohol consumption, and carcinogenic exposures such as hormone replacement therapy (HRT). We need methods of reducing women's risks of this disease that are attractive and easy to use, widely accessible to diverse women, and able to be easily amended to account for new research...
2017: MHealth
https://www.readbyqxmd.com/read/28291838/level-and-correlates-of-physical-activity-and-sedentary-behavior-in-patients-with-type-2-diabetes-a-cross-sectional-analysis-of-the-italian-diabetes-and-exercise-study_2
#19
Stefano Balducci, Valeria D'Errico, Jonida Haxhi, Massimo Sacchetti, Giorgio Orlando, Patrizia Cardelli, Nicolina Di Biase, Lucilla Bollanti, Francesco Conti, Silvano Zanuso, Antonio Nicolucci, Giuseppe Pugliese
OBJECTIVE: Patients with type 2 diabetes usually show reduced physical activity (PA) and increased sedentary (SED)-time, though to a varying extent, especially for low-intensity PA (LPA), a major determinant of daily energy expenditure that is not accurately captured by questionnaires. This study assessed the level and correlates of PA and SED-time in patients from the Italian Diabetes and Exercise Study_2 (IDES_2). METHODS: Three-hundred physically inactive and sedentary patients with type 2 diabetes were enrolled in the IDES_2 to be randomized to an intervention group, receiving theoretical and practical exercise counseling, and a control group, receiving standard care...
2017: PloS One
https://www.readbyqxmd.com/read/28290823/-prevalence-of-risk-factors-of-non-communicable-disease-in-kyrgyzstan-assessment-using-who-steps-approach
#20
T A A, S A Makhmutkhodzhaev, R B Kydyralieva, A T Altymysheva, R S Dzhakipova, K S Zhorupbekova, S T Ryskulova, V G Knyazeva, M T Kaliev, A S Dzhumagulova
Assessment of prevalence of risk factors for non-communicable diseases (NCD) based on WHO "STEPS" approach was conducted in Kyrgyzstan. Results of this study demonstrated high prevalence of NCD risk factors: 94.2% of subjects aged 24-64 years had risk factors. Prevalence of elevated blood pressure was 48.7, smoking - 25.7, hypercholesterolemia - 23.6, excessive alcohol consumption - 31.4, physical inactivity 11.4, obesity - 23.1, elevated glucose level - 4.5, diabetes - 8.8, inadequate intake of fruits and vegetables - 74%...
December 2016: Kardiologiia
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